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ENGINEERING (1267 journals)                  1 2 3 4 5 6 7 | Last

Showing 1 - 200 of 1205 Journals sorted alphabetically
3 Biotech     Open Access   (Followers: 8)
3D Research     Hybrid Journal   (Followers: 21)
AAPG Bulletin     Hybrid Journal   (Followers: 8)
AASRI Procedia     Open Access   (Followers: 14)
Abstract and Applied Analysis     Open Access   (Followers: 3)
Aceh International Journal of Science and Technology     Open Access   (Followers: 2)
ACS Nano     Full-text available via subscription   (Followers: 272)
Acta Geotechnica     Hybrid Journal   (Followers: 7)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 7)
Acta Polytechnica : Journal of Advanced Engineering     Open Access   (Followers: 3)
Acta Scientiarum. Technology     Open Access   (Followers: 3)
Acta Universitatis Cibiniensis. Technical Series     Open Access  
Active and Passive Electronic Components     Open Access   (Followers: 7)
Adaptive Behavior     Hybrid Journal   (Followers: 11)
Adıyaman Üniversitesi Mühendislik Bilimleri Dergisi     Open Access  
Adsorption     Hybrid Journal   (Followers: 4)
Advanced Engineering Forum     Full-text available via subscription   (Followers: 7)
Advanced Journal of Graduate Research     Open Access  
Advanced Science     Open Access   (Followers: 5)
Advanced Science Focus     Free   (Followers: 5)
Advanced Science Letters     Full-text available via subscription   (Followers: 10)
Advanced Science, Engineering and Medicine     Partially Free   (Followers: 7)
Advanced Synthesis & Catalysis     Hybrid Journal   (Followers: 18)
Advances in Calculus of Variations     Hybrid Journal   (Followers: 2)
Advances in Catalysis     Full-text available via subscription   (Followers: 5)
Advances in Complex Systems     Hybrid Journal   (Followers: 7)
Advances in Engineering Software     Hybrid Journal   (Followers: 27)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 17)
Advances in Fuzzy Systems     Open Access   (Followers: 5)
Advances in Geosciences (ADGEO)     Open Access   (Followers: 13)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 21)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 22)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 9)
Advances in Natural Sciences: Nanoscience and Nanotechnology     Open Access   (Followers: 29)
Advances in Operations Research     Open Access   (Followers: 12)
Advances in OptoElectronics     Open Access   (Followers: 6)
Advances in Physics Theories and Applications     Open Access   (Followers: 13)
Advances in Polymer Science     Hybrid Journal   (Followers: 43)
Advances in Porous Media     Full-text available via subscription   (Followers: 5)
Advances in Remote Sensing     Open Access   (Followers: 44)
Advances in Science and Research (ASR)     Open Access   (Followers: 6)
Aerobiologia     Hybrid Journal   (Followers: 3)
African Journal of Science, Technology, Innovation and Development     Hybrid Journal   (Followers: 6)
AIChE Journal     Hybrid Journal   (Followers: 35)
Ain Shams Engineering Journal     Open Access   (Followers: 5)
Akademik Platform Mühendislik ve Fen Bilimleri Dergisi     Open Access   (Followers: 1)
Alexandria Engineering Journal     Open Access   (Followers: 1)
AMB Express     Open Access   (Followers: 1)
American Journal of Applied Sciences     Open Access   (Followers: 26)
American Journal of Engineering and Applied Sciences     Open Access   (Followers: 10)
American Journal of Engineering Education     Open Access   (Followers: 9)
American Journal of Environmental Engineering     Open Access   (Followers: 16)
American Journal of Industrial and Business Management     Open Access   (Followers: 24)
Analele Universitatii Ovidius Constanta - Seria Chimie     Open Access  
Annals of Combinatorics     Hybrid Journal   (Followers: 4)
Annals of Pure and Applied Logic     Open Access   (Followers: 2)
Annals of Regional Science     Hybrid Journal   (Followers: 7)
Annals of Science     Hybrid Journal   (Followers: 7)
Antarctic Science     Hybrid Journal   (Followers: 1)
Applicable Algebra in Engineering, Communication and Computing     Hybrid Journal   (Followers: 2)
Applicable Analysis: An International Journal     Hybrid Journal   (Followers: 1)
Applied Catalysis A: General     Hybrid Journal   (Followers: 6)
Applied Catalysis B: Environmental     Hybrid Journal   (Followers: 18)
Applied Clay Science     Hybrid Journal   (Followers: 6)
Applied Computational Intelligence and Soft Computing     Open Access   (Followers: 11)
Applied Magnetic Resonance     Hybrid Journal   (Followers: 4)
Applied Nanoscience     Open Access   (Followers: 8)
Applied Network Science     Open Access   (Followers: 3)
Applied Numerical Mathematics     Hybrid Journal   (Followers: 5)
Applied Physics Research     Open Access   (Followers: 5)
Applied Sciences     Open Access   (Followers: 3)
Applied Spatial Analysis and Policy     Hybrid Journal   (Followers: 4)
Arabian Journal for Science and Engineering     Hybrid Journal   (Followers: 5)
Archives of Computational Methods in Engineering     Hybrid Journal   (Followers: 5)
Archives of Foundry Engineering     Open Access  
Archives of Thermodynamics     Open Access   (Followers: 8)
Arkiv för Matematik     Hybrid Journal   (Followers: 1)
ASEE Prism     Full-text available via subscription   (Followers: 3)
Asia-Pacific Journal of Science and Technology     Open Access  
Asian Engineering Review     Open Access  
Asian Journal of Applied Science and Engineering     Open Access   (Followers: 1)
Asian Journal of Applied Sciences     Open Access   (Followers: 2)
Asian Journal of Biotechnology     Open Access   (Followers: 8)
Asian Journal of Control     Hybrid Journal  
Asian Journal of Current Engineering & Maths     Open Access  
Asian Journal of Technology Innovation     Hybrid Journal   (Followers: 8)
Assembly Automation     Hybrid Journal   (Followers: 2)
at - Automatisierungstechnik     Hybrid Journal   (Followers: 1)
ATZagenda     Hybrid Journal  
ATZextra worldwide     Hybrid Journal  
Australasian Physical & Engineering Sciences in Medicine     Hybrid Journal   (Followers: 1)
Australian Journal of Multi-Disciplinary Engineering     Full-text available via subscription   (Followers: 2)
Autonomous Mental Development, IEEE Transactions on     Hybrid Journal   (Followers: 9)
Avances en Ciencias e Ingeniería     Open Access  
Balkan Region Conference on Engineering and Business Education     Open Access   (Followers: 1)
Bangladesh Journal of Scientific and Industrial Research     Open Access  
Basin Research     Hybrid Journal   (Followers: 5)
Batteries     Open Access   (Followers: 6)
Bautechnik     Hybrid Journal   (Followers: 1)
Bell Labs Technical Journal     Hybrid Journal   (Followers: 28)
Beni-Suef University Journal of Basic and Applied Sciences     Open Access   (Followers: 4)
BER : Manufacturing Survey : Full Survey     Full-text available via subscription   (Followers: 1)
BER : Motor Trade Survey     Full-text available via subscription  
BER : Retail Sector Survey     Full-text available via subscription   (Followers: 1)
BER : Retail Survey : Full Survey     Full-text available via subscription   (Followers: 1)
BER : Survey of Business Conditions in Manufacturing : An Executive Summary     Full-text available via subscription   (Followers: 3)
BER : Survey of Business Conditions in Retail : An Executive Summary     Full-text available via subscription   (Followers: 3)
Beyond : Undergraduate Research Journal     Open Access  
Bhakti Persada : Jurnal Aplikasi IPTEKS     Open Access  
Bharatiya Vaigyanik evam Audyogik Anusandhan Patrika (BVAAP)     Open Access   (Followers: 1)
Bilge International Journal of Science and Technology Research     Open Access  
Biofuels Engineering     Open Access   (Followers: 1)
Biointerphases     Open Access   (Followers: 1)
Biomaterials Science     Full-text available via subscription   (Followers: 11)
Biomedical Engineering     Hybrid Journal   (Followers: 15)
Biomedical Engineering and Computational Biology     Open Access   (Followers: 13)
Biomedical Engineering Letters     Hybrid Journal   (Followers: 5)
Biomedical Engineering, IEEE Reviews in     Full-text available via subscription   (Followers: 21)
Biomedical Engineering, IEEE Transactions on     Hybrid Journal   (Followers: 37)
Biomedical Engineering: Applications, Basis and Communications     Hybrid Journal   (Followers: 5)
Biomedical Microdevices     Hybrid Journal   (Followers: 9)
Biomedical Science and Engineering     Open Access   (Followers: 4)
Biomedizinische Technik - Biomedical Engineering     Hybrid Journal   (Followers: 1)
Biomicrofluidics     Open Access   (Followers: 4)
BioNanoMaterials     Hybrid Journal   (Followers: 2)
Biotechnology Progress     Hybrid Journal   (Followers: 39)
Bitlis Eren University Journal of Science and Technology     Open Access  
Boletin Cientifico Tecnico INIMET     Open Access  
Botswana Journal of Technology     Full-text available via subscription   (Followers: 1)
Boundary Value Problems     Open Access   (Followers: 1)
Brazilian Journal of Science and Technology     Open Access   (Followers: 2)
Broadcasting, IEEE Transactions on     Hybrid Journal   (Followers: 12)
Bulletin of Canadian Petroleum Geology     Full-text available via subscription   (Followers: 13)
Bulletin of Engineering Geology and the Environment     Hybrid Journal   (Followers: 14)
Bulletin of the Crimean Astrophysical Observatory     Hybrid Journal  
Cahiers, Droit, Sciences et Technologies     Open Access  
Calphad     Hybrid Journal   (Followers: 2)
Canadian Geotechnical Journal     Hybrid Journal   (Followers: 31)
Canadian Journal of Remote Sensing     Full-text available via subscription   (Followers: 42)
Case Studies in Engineering Failure Analysis     Open Access   (Followers: 6)
Case Studies in Thermal Engineering     Open Access   (Followers: 5)
Catalysis Communications     Hybrid Journal   (Followers: 6)
Catalysis Letters     Hybrid Journal   (Followers: 2)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 7)
Catalysis Science and Technology     Free   (Followers: 8)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 3)
Catalysis Today     Hybrid Journal   (Followers: 7)
CEAS Space Journal     Hybrid Journal   (Followers: 2)
Cellular and Molecular Neurobiology     Hybrid Journal   (Followers: 3)
Central European Journal of Engineering     Hybrid Journal  
Chaos : An Interdisciplinary Journal of Nonlinear Science     Hybrid Journal   (Followers: 2)
Chaos, Solitons & Fractals     Hybrid Journal   (Followers: 3)
Chinese Journal of Catalysis     Full-text available via subscription   (Followers: 2)
Chinese Journal of Engineering     Open Access   (Followers: 2)
Chinese Science Bulletin     Open Access   (Followers: 1)
Ciencia e Ingenieria Neogranadina     Open Access  
Ciencia en su PC     Open Access   (Followers: 1)
Ciencias Holguin     Open Access   (Followers: 3)
CienciaUAT     Open Access   (Followers: 1)
Cientifica     Open Access  
CIRP Annals - Manufacturing Technology     Full-text available via subscription   (Followers: 11)
CIRP Journal of Manufacturing Science and Technology     Full-text available via subscription   (Followers: 13)
City, Culture and Society     Hybrid Journal   (Followers: 21)
Clay Minerals     Full-text available via subscription   (Followers: 10)
Clean Air Journal     Full-text available via subscription   (Followers: 1)
Clinical Science     Full-text available via subscription   (Followers: 9)
Coal Science and Technology     Full-text available via subscription   (Followers: 3)
Coastal Engineering     Hybrid Journal   (Followers: 11)
Coastal Engineering Journal     Hybrid Journal   (Followers: 6)
Coatings     Open Access   (Followers: 4)
Cogent Engineering     Open Access   (Followers: 2)
Cognitive Computation     Hybrid Journal   (Followers: 4)
Color Research & Application     Hybrid Journal   (Followers: 2)
COMBINATORICA     Hybrid Journal  
Combustion Theory and Modelling     Hybrid Journal   (Followers: 14)
Combustion, Explosion, and Shock Waves     Hybrid Journal   (Followers: 14)
Communications Engineer     Hybrid Journal   (Followers: 1)
Communications in Numerical Methods in Engineering     Hybrid Journal   (Followers: 2)
Components, Packaging and Manufacturing Technology, IEEE Transactions on     Hybrid Journal   (Followers: 28)
Composite Interfaces     Hybrid Journal   (Followers: 7)
Composite Structures     Hybrid Journal   (Followers: 277)
Composites Part A : Applied Science and Manufacturing     Hybrid Journal   (Followers: 208)
Composites Part B : Engineering     Hybrid Journal   (Followers: 248)
Composites Science and Technology     Hybrid Journal   (Followers: 191)
Comptes Rendus Mécanique     Full-text available via subscription   (Followers: 2)
Computation     Open Access   (Followers: 1)
Computational Geosciences     Hybrid Journal   (Followers: 16)
Computational Optimization and Applications     Hybrid Journal   (Followers: 7)
Computational Science and Discovery     Full-text available via subscription   (Followers: 2)
Computer Applications in Engineering Education     Hybrid Journal   (Followers: 8)
Computer Science and Engineering     Open Access   (Followers: 19)
Computers & Geosciences     Hybrid Journal   (Followers: 31)
Computers & Mathematics with Applications     Full-text available via subscription   (Followers: 8)
Computers and Electronics in Agriculture     Hybrid Journal   (Followers: 5)
Computers and Geotechnics     Hybrid Journal   (Followers: 11)
Computing and Visualization in Science     Hybrid Journal   (Followers: 7)
Computing in Science & Engineering     Full-text available via subscription   (Followers: 33)
Conciencia Tecnologica     Open Access  
Concurrent Engineering     Hybrid Journal   (Followers: 3)
Continuum Mechanics and Thermodynamics     Hybrid Journal   (Followers: 8)

        1 2 3 4 5 6 7 | Last

Journal Cover
Beni-Suef University Journal of Basic and Applied Sciences
Number of Followers: 4  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2314-8535
Published by Elsevier Homepage  [3163 journals]
  • New insights into the medicinal importance, physiological functions and
           bioanalytical aspects of an important bioactive compound of foods
           ‘Hyperin’: Health benefits of the past, the present, the future

    • Authors: Kanika Patel; Vikas Kumar; Mahfoozur Rahman; Amita Verma; Dinesh Kumar Patel
      Pages: 31 - 42
      Abstract: Publication date: March 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1
      Author(s): Kanika Patel, Vikas Kumar, Mahfoozur Rahman, Amita Verma, Dinesh Kumar Patel
      Herbal medicines have been used for the treatment of various disorders in the world since very early age. A large number of phytochemicals have been derived from the natural sources in the form of food supplement, neutraceuticals, oils and colour pigments. Flavonoids are a widely distributed group of phytochemicals having benzo-pyrone nucleus. Till so far more than 4000 different types of flavonoids have been described and categorized into different groups like flavonols, flavones, flavanones, isoflavones, catechins and anthocyanidins. Flavonoids have an attractive candidate in the food industry as natural colorants due to its health beneficial effect and safety issue. Hyperin, an important flvonoid were found in the different plants have various pharmacological activities like antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, antiparasitic, cardioprotective, hepatoprotective and antispasmodic. The aim of this review is to collect all the valuable scientific information of hyperin regarding its medicinal importance, pharmacological activities, isolation and analytical techniques. From the presented data’s in this review it will be beneficial to the scientific person, pharmaceutical manufacturer and consumers in order to it health beneficial effect of hyperin. Thus this valuable information will be helpful to the researchers for developing alternative methods of treatment for different diseases.
      Graphical abstract image

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2017.05.009
  • Antileishmanial potential of medicinal plant extracts from the North-West
           of Morocco

    • Authors: Abdelhakim Bouyahya; Abdeslam Et-Touys; Nadia Dakka; Hajiba Fellah; Jamal Abrini; Youssef Bakri
      Pages: 50 - 54
      Abstract: Publication date: March 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1
      Author(s): Abdelhakim Bouyahya, Abdeslam Et-Touys, Nadia Dakka, Hajiba Fellah, Jamal Abrini, Youssef Bakri
      The aim of this study is to evaluate the antileishmanial activity of selected medicinal plants from the North-West of Morocco. Plant extracts were prepared by maceration using methanol, ethanol, and n-hexane. The antileishmanial activity was evaluated against Leishmania major, Leishmania tropica, and Leishmania infantum using MTT (3-(4.5-dimethylthiazol-2yl)-2.5-diphenyltetrazolium bromide) assay. All plant extracts showed a reducing in cell promastigotes viability with variability depending on tested strains and type of extracts. The n-hexane extract showed the highest antileishmanial activity and L. infantum was the most sensitive parasite. The best growth inhibition was observed with Cistus crispus n-hexane extract against L. major (IC50 =47.29±2.25μg/mL), Arbutus unedo n-hexane extract against L. infantum (IC50 =64.05±1.44μg/mL) and Arbutus unedo n-hexane extract against L. tropica (IC50 =79.57±2.66μg/mL). Considering these results, medicinal plants from the North-West of Morocco could constitute a promoter source for antileishmanial compounds.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2017.06.003
  • Development and functionalization of magnetic nanoparticles as powerful
           and green catalysts for organic synthesis

    • Authors: Ahmed M. Abu-Dief; Shimaa Mahdy Abdel-Fatah
      Pages: 55 - 67
      Abstract: Publication date: March 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 1
      Author(s): Ahmed M. Abu-Dief, Shimaa Mahdy Abdel-Fatah
      Magnetic nanoparticles are a highly worthy reactant for the correlation of homogeneous inorganic and organic containing catalysts. This review deals with the very recent main advances in the development of various nano catalytic systems by the immobilization of homogeneous catalysts onto magnetic nanoparticles. Catalytic fields include the use of mainly cobalt, nickel, copper, and zinc ferrites, as well as their mixed-metal combinations with Cr, Cd, Mn and sometimes some lanthanides. The ferrite nanomaterials are obtained mainly by co-precipitation and hydrothermal methods, sometimes by the sonochemical technique, micro emulsion and flame spray synthesis route. Catalytic processes with application of ferrite nanoparticles include degradation (in particular photocatalytic), reactions of dehydrogenation, oxidation, alkylation, C–C coupling, among other processes. Ferrite nano catalysts can be easily recovered from reaction systems and reused up to several runs almost without loss of catalytic activity. Finally, we draw conclusions and present a futurity outlook for the further development of new catalytic systems which are immobilized onto magnetic nanoparticles.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2017.05.008
  • Clinico-radiographic and histopathologic evaluation of iliac shaft
           fracture in dogs (an experimental study)

    • Abstract: Publication date: June 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2
      Author(s): M.Z. Fathy, G.H. Ragab, M.M. Seif, S.M. Gadallah, Salah Deeb, Nesreen M. Safwat
      The pelvic region has a great importance as it is the connecting ring between the hind limbs and the trunk as well as having special shape. The present study was conducted on 15 adult, mongrel male dogs aged 2–3years and weighted 15–20kg. Iliac shaft fracture was induced experimentally, and the fractured ilium was fixed by Dynamic Compatable Plate (DCP). Fracture healing was evaluated clinically, radiologically and histopahologically. The animals were partially-weight bearing on the limb of operated side 4th day post-operatively and they were full-weight bearing within 17th days post-operatively. The gait was varied from occasional lameness to full function at the 21–28th post-operatively. The results of this study was conducted along 16weeks confirmed that the internal fixation for fractured ilium using a bone plate and screws had a good fixation and healing and all animals returned to normal gait within short time.

      PubDate: 2018-05-31T23:27:13Z
  • Epidemiological determinants correlating hepatitis C and Schistosomiasis
           mansoni in one of Upper Egypt governorates

    • Abstract: Publication date: June 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2
      Author(s): Samah S. Abdel Gawad, Enas Yahia Abu-Sarea, Lamiaa Saleh
      Schistosomiasis and hepatitis C virus (HCV) are endemic diseases with high prevalence in Africa especially in Egypt. Many sociodemographic and behavioral related determinants were implicated to be associated with schistosomiasis, HCV or coinfection. Recently, polymerase chain reaction (PCR) is used as a diagnostic tool as it is a sensitive and a specific method especially in early stage of infection. But, diagnosis of S. mansoni is depending on microscopic examination remains the most widely used direct diagnostic method in endemic area. The current study was carried out to determine the prevalence of schistosomiasis mansoni, HCV and confection if any among the studied population, to identify any associated factors for schistosomiasis mansoni, HCV or coinfection if any. A descriptive cross sectional study was conducted on 400 participants, inhabitants in Beni-Suef Governorate, Upper Egypt. The studied population was screened for both schistosomiasis mansoni and HCV. They were subjected to fulfill a well-structured field tested interviewing questionnaire focusing on many suspected associated factors. Moreover, testing the performance characteristics of the used techniques was determined. The prevalence of schistosomiasis mansoni was (2.8%) and HCV was (42.5%) among the studied subjects. The study highlights on many behavioral and sociodemographic determinants significantly associated with HCV infection such as home crowding index, shaving at the community barber, sharing razors within the family, delivery at home and circumcision outside the health settings. Also, the study revealed that there are certain determinants associated with both schistosomiasis mansoni and HCV infection such as blood transfusion and liver cirrhosis. Studying the linked determinates with schistosomisis and HCV is the cornerstone to plan and implement a preventive strategy in the Upper Egypt. Thus, further studying the associated environmental determinants in relation to schistosoimasis, HCV and coinfection is recommended in the Upper Egypt.

      PubDate: 2018-05-31T23:27:13Z
  • Effect of DPI's training-device on inhalation technique and clinical
           efficacy in asthmatics

    • Abstract: Publication date: June 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2
      Author(s): Mina Nicola, Ahmed A. Elberry, Ossama M. Sayed, Raghda R.S. Hussein, Mohamed E.A. Abdelrahim
      The aim of this work was to study the effect of using training device (In-Check DIAL) along with traditional dry powder inhaler (DPI) counseling on inhalation technique and pulmonary functions test (PFT) in asthmatics. Adult asthmatics >18 years old were recruited in 3months study of investigation and training. They were divided into control and investigation groups. DPI inhalation technique was checked and mistakes were noted and corrected at every monthly visit. Their peak expiratory flow and forced expiratory volume in 1second as percentage of forced vital capacity were checked at each visit followed by showing patients the correct inhalation technique and how to use In-Check DIAL (investigation group). 29 patients (14 females) and 57 patients (30 females) in control and investigation groups respectively completed the study. Mean number of mistakes was significantly decreased (p < .001) as the counseling session increased in both groups. Significant decrease in crucial mistake (inhalation quickly and forcefully until complete filling up of the lungs) that was very hard to be learned via only verbal counseling was noticed after the addition of In-Check DIAL. The improvement of the PFT results were significant from the second visit in the investigation group (p < .05) and from the third visit in the control group (p < .001). The decrease in the rate of rescue medication consumption was faster in investigation group than control group. Using training device along with verbal counseling has proven a beneficial role in inhalation technique resulting in optimum dosage delivery and yielding reasonable improvement in PFT.

      PubDate: 2018-05-31T23:27:13Z
  • Apoptotic efficiency of aqueous extracts of turmeric, garlic and their
           active compounds in combination with Tamoxifen in lung and oral cancers: A
           comparative study

    • Abstract: Publication date: June 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2
      Author(s): Satish Kumar Vemuri, Rajkiran Reddy Banala, Subbaiah GPV, Gurva Reddy AV, Malarvili Thekkumalai
      Anticancer treatment against oral and lung cancers has caught the eye of oncologist and researchers worldwide as most common cause deaths in India and worldwide is due to these cancers and most of the treatment strategies employed are not showing any effectiveness against neoplastic ability of the cancers. One of the reasons for cancer deaths could be because of poor prognosis and associated therapies. The existing cancer agents are being re-evaluated and development of new mechanisms of treatment being explored continuously, but it’s inadequate in offering treatment. Therefore, endeavors for new anticancer agents with high efficacy and considerable side effects still going on. The literature reviews shows numerous medicinal plants exhibiting anti-proliferative, pro-apoptotic, anti-metastatic and anti-angiogenic properties and these effects were reported by conducting both in vitro experiments and animal studies. Use of natural phytochemical compounds in cancer chemoprevention is an emerging strategy to forestall the cancer progression or cure cancer. In the present study we have attempted to evaluate the efficacy of Curcumin longa and Allium sativum aqueous extracts individually and in combination with its active compounds (Curcumin and Quercetin) and also with Tamoxifen hydrochloride. Our results suggest that aqueous extracts of Curcumin longa and Allium sativum were effective in inducing apoptosis and cell death in two immortal cell lines i.e. A549 and SCC-9 (Adeno carcinoma of lung, squamous cell carcinoma of tongue), but there was no apoptosis or cell senescence in normal cell line (HEK 293). There was significant increase in apoptosis and cell senescence in combination therapy. Hence a combination of natural extracts along with Tamoxifen can be considered an alternate in cancer treatments but this requires more research.

      PubDate: 2018-05-31T23:27:13Z
  • Molecular docking and quantitative structure-activity relationship study
           of anticonvulsant activity of aminobenzothiazole derivatives

    • Abstract: Publication date: June 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences, Volume 7, Issue 2
      Author(s): Usman Abdulfatai, Adamu Uzairu, Sani Uba
      In silico studies which include Quantitative structure-activity relationship (QSAR) and molecular docking studies were carried out on the 37 amino-benzothiazole derivatives (anticonvulsant agents). Genetic function approximation (GFA) of Material studio software version 8 was used to perform the QSAR study while Autodock vina version 4.0 of Pyrx software was used to perform the molecular docking of all the anticonvulsant agents. The high value of the correlation coefficient (R2) of 0.961 and the R2pred = 0.925 indicated that the model was satisfactory. Molecular docking analyses with Gamma-aminobutyric acid aminotransferases (GABAAT) revealed that aminobenzothiazole derivatives (anticonvulsant agents) with the best binding affinity was found to be −9.1 kcal/mol. The proposed model has good stability, robustness, and predictability on verifying with internal and external validation. The physicochemical parameters are to be considered when improving the inhibitory activities of the aminobenzothiazole derivatives against an enzyme that causes epilepsy (GABAAT).

      PubDate: 2018-05-31T23:27:13Z
  • Production of new rhamnolipids Rha C16-C16 by Burkholderia sp. through
           biodegradation of diesel and biodiesel

    • Abstract: Publication date: Available online 24 May 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): A.B. Abeer Mohammed, Ahmed A. Tayel, Nihal M. Elguindy
      Burkholderia sp. C3 was previously isolated from polycyclic aromatic hydrocarbons (PAH) contaminated soil; it was evaluated for the ability to utilize a range of diesel and biodiesel as sole carbon sources. Burkholderia sp. C3 could degrade 99% of diesel and biodiesel supplemented at 2% (v/v) in a basal mineral medium within 3 days of incubation at 30 °C. The produced rhamnolipids (RL), from diesel degrading bacteria, were characterized by Orcinol test and Mass spectrometry (MS). The MS confirmed that RLs structure compounds had a mixture of mono-rhamno-mono-lipidic, mono-rhamno-di-lipidic and di-rhamno-di-lipidic congeners. Burkholderia sp. produced a mixture of rhamnolipid homologues, as identified by mass spectrometry, while the composition of rhamnolipids depended upon the carbon substrates. The homologues rhamnolipid Rha-Rha-C10-C10, Rha-C10-C10 and Rha-Rha-C12-C12 were the predominant structures. Rha-C12-C14, Rha-C10-C12, Rha-Rha-C10-C12, and Rha-Rha-C12-C14 were detected as minor components. The efficient employment of Burkholderia sp., for the bioremediation of diesel contamination and production of RLs from it, could be recommended from this study.

      PubDate: 2018-05-31T23:27:13Z
  • Effect of different sterilization methods on physicochemical and
           microbiological properties of rice wine during the preservation

    • Abstract: Publication date: Available online 9 May 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Tie-Yan Jin, Kandasamy Saravanakumar, Myeong-Hyeon Wang
      The present study investigated the effect of three different sterilization methods (high hydrostatic pressure sterilization, ultraviolet sterilization and ultra-high temperature sterilization) on changes of physicochemical and microbiological properties of rice wine Makgeolli during the preservation at 15°C for 20 weeks. The results indicated that pH, titratable acidity, color, contents of reducing sugar and alcohol were not significantly varied between different sterilization methods but microbial counts and sensory evaluation were exhibited the significant differences. The microbial counts of the sterilized Makgeolli were significantly lower than that in unsterilized one after 20 weeks of storage. Sensory profiles were markedly dependent on the sterilization methods. This work inferred, the high hydrostatic pressure treatment as the suitable method of sterilization for improving the shelf life of rice wine Makgeolli.

      PubDate: 2018-05-31T23:27:13Z
  • Biological and phytochemical studies of different leaves extracts of
           Pteropyrum scoparium

    • Abstract: Publication date: Available online 8 May 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Afaf Mohammed Weli, Samiya Al-Salmi, Horiya Al Hoqani, Mohammad Amzad Hossain
      Pteropyrum scoparium (P. scoparium, Sidaf) is a medicinally important plant available in most of the tropical countries including Sultanate of Oman and locally it is used to treat dyspepsia and blood purifying agent. The aim of the present study is to prepare leave extracts of different polarities and to evaluate their phytochemicals, total phenols content, antioxidant and antimicrobial activities. The leaves of the plant were extracted with absolute ethanol by maceration method at ambient temperature for one week. The extract was filtered and evaporated to dryness by using rotary evaporator. The residue was suspended in equal volume of ethanol: water and fractionation with hexane, chloroform, and butanol, respectively. The total phenols content, antioxidant and antimicrobial activities of four prepared extracts were evaluated by Folin-Ciocalteu reagent (FCR), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and agar disc diffusion methods. The highest amount of phenols content was found in hydro alcoholic extract and the lowest content was in hexane to be in the order of hydro alcohol > butanol > chloroform > hexane extract. The main antioxidant activity was found in residue from butanol and the minimum activity was in that from chloroform, the order of antioxidant activity; butanol > hydro alcoholic > hexane > chloroform extract. The antibacterial activity of ethanol extract and its derived fractions of the plant against one Gram-positive Staphylococcus aureus (S. aureus) and one Gram-negative Escherichia coli (E. coli) bacteria strains were qualitatively assessed by the presence or absence of inhibition zones. All the extracts of the selected plant at most of the concentrations did not exhibit potent antibacterial activity. The phytochemical studies of the prepared extracts, showed that all the extract contains saponins, steroids, and terpenoids. In addition to that, the chloroform, butanol and hydro-alcohol extract contains tannins and glycoside. In conclusion, all the crude extracts showed significant antioxidant activity. It could be used as natural antioxidant instead of synthetic one.

      PubDate: 2018-05-31T23:27:13Z
  • Central composite design for optimization of preparation conditions and
           characterization of hydroxyapatite produced from catfish bones

    • Abstract: Publication date: Available online 26 April 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Farombi Abolaji Grace, Amuda Omotayo Sarafadeen, Alade Abass Olanrewaju, Okoya Aderonke, Olayiwola Olusegun Akeem, Adebisi Segun Akanmu
      Hydroxyapatite (HAP) was prepared from catfish bones at optimized conditions by employing Central Composite Design (CCD) under Response Surface Methodology (RSM). The temperature of preparation ranges between 300 and 1000 °C and time was varied between 1 and 2 h. The software gave thirteen (13) runs experiment within the conditions. 10 g of treated catfish bones inside crucible was calcined in the furnace at the temperatures and times suggested by the software. The yield percentages were determined and a standard method of pore size estimation Methylene Blue Number Method was used to estimate the adsorption capacity of the calcined catfish bones (CFHAP). Hence, the optimized conditions for adsorption were deduced. Characterization of the catfish bones before and after calcinations was studied by using Scanning Electron Microscopy (SEM); Fourier Transform Infrared Spectroscopy (FTIR;) Energy Dispersive X –ray Spectroscopy (EDX) and Brunaver-Emmett-Teller (BET). The results confirmed that the product is hydroxyapatite.

      PubDate: 2018-05-31T23:27:13Z
  • Spectrophotometric and tandem mass spectroscopic analysis of Indian borage
           (Plectranthus amboinicus (Lour.) Spreng.) for its polyphenolics

    • Abstract: Publication date: Available online 26 April 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): C.T. Sulaiman, M. Deepak, Indira Balachandran
      Plectranthus amboinicus (Lour.) Spreng. has been used for the treatment of many diseases in traditional Indian systems of medicine. In the present study, Polyphenolic profiling was carried out in leaves of P. amboinicus using spectrophotometric and mass spectroscopic analyses. The total Polyphenolics of different extracts such as ethanol, acetone and n-butanol were estimated spectrophotometrically and major phenolic compounds of ethanol extract was characterized by HPLC coupled tandem mass spectroscopic analysis.

      PubDate: 2018-05-31T23:27:13Z
  • Design synthesis in silico in vitro and in vivo evaluation of novel
           l-cysteine derivatives as multi-target-directed ligands for the treatment
           of neurodegenerative diseases

    • Authors: Vadivel Kannan; Manohar Babu Sitty; Muthusamy Periyannan
      Abstract: Publication date: Available online 19 April 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Kannan Vadivel, Sitty Manohar Babu, Periyannan Muthusamy
      There are four major molecular mechanisms involved in the neuronal cell death are excitotoxicity, neuroinflammation, apoptosis and oxidative stress. Our objective is to explore in silico, in vitro and in vivo evaluation of neuroprotective potential of novel L-Cysteine derivatives as multi-target-directed drugs to manage neurodegenerative diseases. Fifty molecules were designed and included in the in silico analysis to evaluate their druglikeness and binding affinities towards the selected target proteins using various pharmacokinetic and docking software. Based on in silico results and synthetic feasibility, nine compounds were selected for synthesis, spectral analysis, in vitro and in vivo neuroprotective evaluation on neuroblastoma cell line and aluminium induced neurotoxicity in rats. Selected compounds gained best docking score and obey Lipinski’s rule of five. In vitro results showed that the compound 1a and 1b significantly increased the percentage viability (81.03 ±4.78 and 76.1 ±1.99) of human neuroblastoma cells at concentration of 100 µg. Mean retention latencies and oxidative stress were significantly decreased (P < 0.01) in test 2 and test 3 groups on day 21 and 42 when compared to disease control. In vitro study revealed the significant neuroprotective effect of compound 1a and 1b against glutamate induced neurotoxicity in SH SY-5Y cell line. The retention latency and biochemical parameters suggest that 1a has neuroprotective effect in aluminium induced Alzheimer’s disease model in rats.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.04.001
  • Three-dimensional finite element analysis of a porcelain crowned tooth

    • Authors: Bankole.I. Oladapo; S. Abolfazl Zahedi; F. Vahidnia; O.M. Ikumapayi; Muhammad U. Farooq
      Abstract: Publication date: Available online 17 April 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Bankole.I. Oladapo, S. Abolfazl Zahedi, F. Vahidnia, O.M. Ikumapayi, Muhammad U. Farooq
      The restoration of endodontically treated teeth is one of the main challenges in restorative dentistry since the weakened tooth structure is more prone to biomechanical failures due to significant tooth loss. The aim of this paper is to computational analysis of prepared crowned tooth in order to differentiate the possibility of using porcelain material for typical clinical condition and masticatory load by using the three-dimensional finite element method (3D FEM). In order to have an accurate geometry of tooth model, a coordinate measuring machine (CMM) is proposed to scan the tooth. The obtained scanned contours exported to ABAQUS FE package for computational stress analysis. The prosthodontics crown FEM has been created and put on simulated chewing stresses. The model is composed of four different materials, namely; prepared tooth, luting cement, substructure (IPS Empress Core), and Ingot (IPS Empress Layer). The generated FEM run and the stress distributions of the crowned tooth is thoroughly investigated. The developed model is extremely useful for indicating tooth biomechanics and has the tendency to deliver a better understanding to designers in the biomedical engineering field and dentistry.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.04.002
  • Microwave-assisted extraction and characterization of fatty acid from eel
           fish (Monopterus albus)

    • Authors: Haruna Kolawole Afolabi; Siti Kholijah Abdul Mudalip; Oluwaseun Ruth Alara
      Abstract: Publication date: Available online 17 April 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Haruna Kolawole Afolabi, Siti Kholijah Abdul Mudalip, Oluwaseun Ruth Alara
      Eel fish (Monopterus albus) is a functional food that has shown remarkable effects on a range of diseases, which include inflammatory diseases, type 2 diabetes and cancer. This study emphasized on the use of microwave-assisted extraction (MAE) technique in studying the effects of three MAE parameters (irradiation time, microwave temperature and microwave power) to obtain extract from eel fish using ethanol as the extracting solvent. The free fatty acid (FFA), acid value, fatty acid contents, and functional groups in the extract were also examined. More so, the maximum extraction yield of 16.13% w/w was obtained at a microwave power of 800 W, FFA and acid value of 1.35 and 2.69 mg KOH/g, respectively confirmed good quality of the obtained extract. In addition, the major fatty acid contents in the extract using gas chromatography-mass spectrometry (GC-MS) analysis were arachidonic acid, linolenic acid, myristic acid, oleic acid, palmitic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Consequently, the Fourier transform infrared spectrometry (FTIR) analysis confirmed the presence of different functional groups in the extract. Therefore, this study divulged that MAE is an efficient and reliable technique for extracting high yields of fatty acids from M. albus fish with a notable potential for industrial applications.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.04.003
  • An evidence of fungal derived 1-aminocyclopropane-1-carboxylate deaminase
           promoting the growth of mangroves

    • Authors: Kandasamy Saravanakumar; Davoodbasha MubarakAli; Kandasamy Kathiresan; Myeong-Hyeon Wang
      Abstract: Publication date: Available online 7 April 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Kandasamy Saravanakumar, Davoodbasha MubarakAli, Kandasamy Kathiresan, Myeong-Hyeon Wang
      The present study reports the enzyme 1-aminocyclopropane-1-carboxylate deaminase (ACCD) from Trichoderma strains TSK8 and SKS1 enhance the growth mangroves (Rhizophora) evidenced by primary enzyme quantification followed by greenhouse experiments. The results indicated that ACCD enzyme activity about 20% higher in strain SKS1 than that of strain TSK8. In the greenhouse study, we analyzed the effect of Trichoderma treatment on physiological and biochemical characteristics of mangrove seedlings. The results demonstrated that SKS1 significantly enhanced the growth of mangroves (Rhizophora apiculata and Rhizophora mucronata) as compared to control (untreated). The strain TSK8 and SKS1 increased the plant total biomass by 43.26% and 41.23% respectively in R. mucronata. Particularly, SKS1 showed the 70.8% biomass increase in R. apiculata. The growth was investigated with and without the addition of soluble phosphate were investigated. Thusly, the fungal strains SKS1 and TSK8 derived ACCD has potency on the mangroves growth enhancement. Thus present work provided the platform for the development of Trichoderma sp. based biofertilizer for a promising approach for the restoration of aquatic plants.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.03.013
  • Design regulatory interaction network for anxiety disorders using R: A
           bioinformatics approach

    • Authors: Nahida Habib; Bikash Kumar Paul; Md. Shadidul Islam; Kawsar Ahmed
      Abstract: Publication date: Available online 6 April 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Nahida Habib, Bikash Kumar Paul, Md. Shadidul Islam, Kawsar Ahmed
      Bio-informatics research fields are progressively growing enriched with the incremental use of R tools. Anxiety Disorders can be defined as one of the most common mental disorders. They are tangible psychiatric disorders or a group of mental illnesses thought to be caused by either genetic vulnerability or environmental susceptibility factors. Several studies have revealed that anxiety is associated with an increased risk of Angina, Asthma, Diabetes, Heart Attack and High Blood Pressure. Thus, these five anxiety disorders must have some genetic association among them. Finding the genetic relationship among the above diseases will help to understand the gene linkage and connection association among them which leads to the way to common drug design. Here, after investigating the genetic association of Angina, Asthma, Diabetes, Heart Attack and High Blood Pressure a Regulatory Interaction Network is designed using R. The investigated diseases genes are collected, preprocessed, processed, mined and optimized using R. This research aimed to create a new dimension in the field of drug design.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.03.014
  • Preliminary cephalometric study of the relationship between facial
           morphology and sex

    • Authors: Alhassan Kadri; Williams Kweku Darkwah; Abaidoo Chrissie Stassie; Gideon Aidoo; Atuahene Ohene-Djan
      Abstract: Publication date: Available online 3 April 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Alhassan Kadri, Williams Kweku Darkwah, Abaidoo Chrissie Stassie, Gideon Aidoo, Atuahene Ohene-Djan
      Morphology of the face depends on many factors, such as sex, ethnicity, race, climate, nutrition, genetic constitution and socio-economic status. In the developed countries, there is well established database on facial anthropometry and for the purpose of identification. In Ghana however, there is very little documented information on cephalometric indices for biometric and forensic purposes. This study therefore, aimed at establishing baseline data to assess the relationship between sex using upper, lower and total cephalometric indices. One hundred participants made up of sixty males and forty females from KNUST were recruited for the study. Linear facial anthropometry were taken using calibrated Shahe digital calipers whiles participants sat with head in natural position. The facial anthropometric measurements were generally higher in males than in females. Upper facial height, facial width, nasal width, biocular diameter, lower facial height, lip length and total facial height were statistically significant and (p < 0.05). The present study shows the existence of statistically significant sexual dimorphism in the study population using cephalo-facial dimensions.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.03.004
  • Efficient extraction of antioxidants from Vernonia cinerea leaves:
           Comparing response surface methodology and artificial neural network

    • Authors: Oluwaseun Ruth Alara; Nour Hamid Abdurahman; Haruna Kolawole Afolabi; Olusegun Abayomi Olalere
      Abstract: Publication date: Available online 28 March 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Oluwaseun Ruth Alara, Nour Hamid Abdurahman, Haruna Kolawole Afolabi, Olusegun Abayomi Olalere
      Despite response surface methodology (RSM) has been the most preferred statistical tool for optimizing extraction processes, artificial neural network (ANN) has been one of the most effective tools used for optimization and empirical modelling since the last two decades, most especially for non-linear equations. Thus, this study was carried out to compare the performance of RSM and ANN in optimizing the extraction yield and antioxidant capability of extract from Vernonia cinerea leaves using microwave-assisted extraction (MAE) techniques. The responses (extraction yield and antioxidant capabilities) were modelled and optimized as functions of four independent MAE parameters (irradiation time, microwave power level, ethanol concentration, and feed-to-solvent ratio) using RSM and ANN. The coefficient of determination (R2), root mean square error (RMSE) and absolute average deviation (AAD) were employed to compare the performance of both modelling tools. ANN model has a higher predictive potential compared to RSM model with higher correlation coefficients of 0.9912, 0.9928 and 0.9944 for extraction yield, DPPH and ABTS scavenging activities, respectively. Thus, ANN model could be a better alternative in data fitting for the MAE of antioxidants from Vernonia cinerea leaves.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.03.007
  • Interplay of electrically conducting and non conducting walls on
           magnetohydrodynamic mixed convection flow in vertical permeable
           micro-channel in existence of induced magnetic field

    • Authors: Basant K. Jha; Babatunde Aina
      Abstract: Publication date: Available online 26 March 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Basant K. Jha, Babatunde Aina
      In this article, flow formation of fully developed mixed convection flow of an incompressible, viscous and electrically conducting fluid in vertical permeable micro-channel in presence of induced magnetic field is analyzed. The effects of velocity slip and temperature jump are taken into account. The influence of induced magnetic field arising due to the motion of an electrically conducting fluid in the presence of transverse magnetic field is taken into consideration. The governing equations of the motion are a set of simultaneous ordinary differential equations and their exact solutions in dimensionless form have been obtained for the velocity field, the induced magnetic field and the temperature field. The expressions for the induced current density and skin friction have also been obtained. Numerical procedures are examined for various active parameters namely: suction/injection, rarefaction, fluid wall interaction, mixed convection, Hartmann number and the magnetic Prandtl number. Results revealed that, increase in Hartmann number and magnetic Prandtl number causes a pronounced reduction in skin friction.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.03.011
  • Design and assessment of pulsatile technology based chronomodulated
           delivery systems of nifedipine

    • Authors: Sowjanya Battu; Prasanna Raju Yalavarthi; G.V. Subba Reddy; V. Uma Maheswara Rao; K. Jyothshna Devi; Harini Chowdary Vadlamudi
      Abstract: Publication date: Available online 26 March 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Sowjanya Battu, Prasanna Raju Yalavarthi, G.V. Subba Reddy, V. Uma Maheswara Rao, K. Jyothshna Devi, Harini Chowdary Vadlamudi
      Nifedipine has poor aqueous solubility which limits its oral absorption as unit formulation. This limitation was acted through multiparticulate pulsatile systems for the treatment of angina pectoris. Initially, solid dispersions of nifedipine (NF) using sodium starch glycolate (SSG) and guar gum (GG) in 1:1 and 1:2 ratios were processed by kneading technique. Solution layering technique was employed to coat the solid dispersions on non-pareil sugar spheres (∼450 µm) to obtain immediate (NMP 1 and 2) and controlled release pellets (NMP-3 and 4). Controlled release pellets were further coated with Eudragit L100 and RS100 to achieve pulsatile pellets (NMPP-1 to 5). Pellets were subjected to saturation solubility, FTIR, DSC, micromeritics, SEM, drug content, drug release, pharmacokinetic and stability studies. By means of solid dispersions, solubility of NF was increased by 130-folds due to encompassing ordered interparticle mixing of NF and carriers. Significant interactions between NF and carriers were not demonstrated in FTIR spectra as well as in DSC thermograms. Fluidization process again proved its supremacy in producing defined spherical shaped pellets with desired micromeritics. Solution layering process resulted with high drug content (81–94.2%) and maximum drug was released by end of 12 h with 6 h lag phase. Suitable pharmacokinetic parameters were moderated by immediate (NMP) and pulsatile pellets (NMPP) as Cmax of 820 ng/mL for NMP-2 and 360.8 ng/mL for NMPP-5 at 5 and 16 h respectively. Increased pharmacokinetics and bioavailability were the result of linear increase in solubility of NF with solid dispersions. The pulsatile formulations were physicochemically intact over a period of time. Thus, multiparticulate systems of NF had demonstrated their applicability in chronotherapy of circadian based ailments.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.03.012
  • Optimization of the anticonvulsant activity of
           2-acetamido-N-benzyl-2-(5-methylfuran-2-yl) acetamide using QSAR modeling
           and molecular docking techniques

    • Authors: Oluwaseye Adedirin; Adamu Uzairu; Gideon A. Shallangwa; Stephen E. Abechi
      Abstract: Publication date: Available online 24 March 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Oluwaseye Adedirin, Adamu Uzairu, Gideon A. Shallangwa, Stephen E. Abechi
      Chemometric descriptors were used to analyze quantitatively the anticonvulsant activity of ninety propanamide derivatives. Molecular geometries of the data set were optimized with B3LYP/6-31G∗∗ quantum mechanical method and chemometric descriptors were calculated from the optimized structure. Linear QSAR models were developed using genetic function algorithm. Predictive capabilities of the models were evaluated using various internal and external validation techniques. The best three models proposed were octa-parametric equation with good statistical quality: R2 (0.898–0.918); Q2 (0.865–0.893); R2 pred (0.746–0.772) and F (66.657–88.036). 2-acetamido-N-benzyl-2-(5-methylfuran-2-yl) acetamide a member of the data set was chosen as scaffold for in silico design. Using the information afforded by the models, several attempts were made to optimize the scaffold by introducing various modifications. Potential derivatives with higher predicted activity values than the template were identified and a detailed analysis on the models applicability domain defined the designed compounds, whose estimations can be accepted with confidence. Some of the designed compounds docked with γ-aminobutyrate aminotransferase (PBD: 1OHV) (target) showed better binding affinity for the target when compare with 4-aminohex-5-enoic acid (vigabatrin) (a known inhibitor of the target).

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.03.010
  • Morphological, histological and ultrastructural studies on the exocrine
           pancreas of goose

    • Authors: Rasha Ragab Beheiry; Waheed Abdel-Azeem Abdel-Raheem; Ahmed Mostafa Balah; Hoda Foad Salem; Mayada Wahid Karkit
      Abstract: Publication date: Available online 22 March 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Rasha Ragab Beheiry, Waheed Abdel-Azeem Abdel-Raheem, Ahmed Mostafa Balah, Hoda Foad Salem, Mayada Wahid Karkit
      The present work was aimed to study the morphological and histological features of goose pancreas and to investigate the ultrastructure of pancreatic acini. This study was conducted on the pancreas of ten healthy mature birds of goose. The pancreas was excised from the duodenum rapidly after slaughter of the birds. The specimens were fixed in 10% buffered neutral formalin then processed for light and electron microscopic study. The macroscopic observations revealed that goose pancreas was located in the right side of the abdomen between the ascending and descending loops of duodenum. It was formed from dorsal, splenic, ventral and third lobes. The histological observations revealed that the pancreas was formed of lobules of serous acini. The secretory acinus unit was appearing as a single spherical mass composed of many serous cells surrounding narrow lumen. The pyramidal acinar cells appeared bizonal structure; the basal basophilic cytoplasm and apical acidophilic cytoplasm. Centroacinar cells were slightly smaller cells that appeared brighter than the acinar cells and were located in the center of the lumen of the acinus. The duct system was well developed began with the centroacinar cells. Underneath electron microscope, the acinar cells have been two kinds, the electron dense acinar cells with electron dense cytoplasm and heterochromatic nuclei and the electron lucent acinar cells, which characterized by means of electron lucent cytoplasm, and their nuclei had considerable euchromatin, abundant endoplasmic reticulum, mitochondria and numerous zymogen granules, and considered active cells.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.03.009
  • Variation in seasonal prevalence and intensity of progenetic metacercariae
           of Clinostomum complanatum infection in Trichogaster fasciatus fish

    • Authors: Shabnam Khan; Sakil Ahmed; M. Serajuddin; Mohammad Khalid Saifullah
      Abstract: Publication date: Available online 19 March 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Shabnam Khan, Sakil Ahmed, M. Serajuddin, Mohammad Khalid Saifullah
      A total of 1242 out of 1484 Trichogaster fasciatus fish were found to be infected with metacercarial stage of Clinostomum complanatum where 14,258 parasites were recorded mainly from the peritoneal cavity, gills and viscera during five years of study period. The seasonal variations in prevalence, intensity and abundance of the parasitic infection were assessed. The maximum and minimum values of prevalence of metacercarial infection of C. complanatum in the fish were 92.40% and 70.40% during summer and winter respectively. Similarly, intensity and abundance of the parasite were maximum during summer as compared to winter and rainy seasons. The high prevalence of infection of the parasite during summer may be because of the time of emergence of cercariae in high temperature from snail vector and the environment.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.03.006
  • Water demand and waste management with respect to projected urban growth
           of Gurugram city in Haryana

    • Authors: Anil Kumar Misra; Misbah Masoodi; Rohith P. Poyil; Naval Kishore Tewari
      Abstract: Publication date: Available online 17 March 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Anil Kumar Misra, Misbah Masoodi, Rohith P. Poyil, Naval Kishore Tewari
      Gurugram city (Haryana state) has witnessed unprecedented urban growth over the past two decades, owing to the escalation in population, immigration and unorganized expansion. Present study examines the spatial determinants and different features of urban growth till 2011 in the Gurugram city and based on the growth rates and probable demands, land use pattern changes for 2031, 2041 and 2051 have been projected. Using photogrammetric analysis, orthoimage of Gurugram city was prepared and through visual image interpretation land use map of Gurugram city was generated. The population escalation was calculated using population estimation method and land use pattern of Gurugram city was predicted for 2031, 2041 and 2051. Based on the land cover and land use pattern changes, strategies for managing the water resource and solid waste management have been proposed. Probable future changes in land cover patterns, urban growth and land use patterns are very useful for urban planning and managing the natural resources. The results of the study could help in understanding the urban growth processes and their patterns, and facilitate urban planners and policy makers to deal with rapid urban agglomeration processes and associated problems.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.03.003
  • Amelioration of DENA-induced oxidative stress in rat kidney and brain by
           the essential oil of Elettaria cardamomum

    • Authors: Nihal M. Elguindy; Galila A. Yacout; Eman F. El Azab
      Abstract: Publication date: Available online 15 March 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Nihal M. Elguindy, Galila A. Yacout, Eman F. El Azab
      The goal of the present work was to study the protective role of the essential oil of Elettaria cardamomum (cardamom) against diethylnitrosamine (DENA)-induced oxidative stress in the kidney and brain of rats in comparison with geraniol, a pure compound as one of the main components of cardamom essential oil. Geraniol or cardamom essential oil was orally administered every day (100 and 200 mg/kg) for 1 week before DENA administration and continuously administered for 26 weeks. The levels of brain and kidney ornithine decarboxylase (ODC), brain acetylcholinesterase (AChE) and renal markers such as urea and creatinine were elevated after DENA administration. However, cardamom and geraniol administration decreased kidney and brain oxidative stress and lowered the activity of ODC in brain and kidney and the activity of AChE in brain. Cardamom or geraniol had significantly reduced the level of lipid peroxidation to almost half the value in DENA group and enhanced glutathione level by double its values in brain and kidney compared to glutathione levels in DENA treated-rats. In addition, geraniol or oil of cardamom improved the activities of the antioxidant markers; catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, and glutathione-S transferase in the brain and kidneys of DENA-treated rats. The results support the chemopreventive, antioxidant, neuroprotective and anticancer effects of the essential oil of cardamom, which are mediated through its inhibition of ODC and AChE activities and activation of antioxidant markers.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.02.005
  • Seasonal and spatial variation of aquatic macrophytes and phytoplankton
           community at El-Quanater El-Khayria River Nile, Egypt

    • Authors: Mostafa M. El-Sheekh; Amany M. Haroon; Soad Sabae
      Abstract: Publication date: Available online 15 March 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Mostafa M. El-Sheekh, Amany M. Haroon, Soad Sabae
      In this study, the phytoplankton biomass and species composition in El-Quanater El-Khayria (River Nile, Egypt) was analyzed at four sampling sites on a program of a seasonally sampling and supported by measurements of different water variables as well as biomass production of most common aquatic macrophytes. The major species of aquatic macrophytes were two submerged species (Ceratophyllum demersum and Ceratophyllum submersum), two emergent (Polygonum tomentosum and spontaneum), and one free floating aquatic macrophyte (Eichhornia crassipes). Considerable seasonal variations in water quality as well as macrophytes biomass were found in the studied areas, which result in a variation of phytoplankton flora. A total of 235 phytoplankton species belonging to 7 classes was recorded, with higher numbers in autumn and winter compared to spring and summer. The maximum number of phytoplankton (7238 × 104 L−1 cells) was recorded in winter, however, the lowest one (96 × 104 L−1 cells) recorded in spring. Chlorophyceae was the dominant group, forming 56.96% of the total phytoplankton biomass followed by Bacillariophyceae (34.82%), Cyanophyceae (7.99%), Cryptophyceae (0.10%), Dinophyceae (0.096%), Chrysophyceae (0.03%) and Euglenophyceae (0.02%). Chlorophyll a values ranged from 9.77 µg L−1 to 69.81 µg L−1, with a considerable seasonal and spatial variation. All phytoplankton classes as well as, chlorophyll a was negatively correlated with all aquatic macrophytes species except for C. submersum which correlated positively with chlorophyll a and Cyanophyceae. In addition, it was positively correlated with pH, conductivity and dissolved oxygen.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.03.002
  • BNP as a promising marker in prediction of malignant arrhythmias in pts
           with LV systolic dysfunction after an acute MI

    • Authors: Ahmed Yassin; MohamedAbo Hamila; Ahmed Battah; Amal Rizk; SheriefMokhtar
      Abstract: Publication date: Available online 10 March 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Ahmed Yassin, MohamedAbo Hamila, Ahmed Battah, Amal Rizk, SheriefMokhtar

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.02.008
  • Development and screening of mutants from Monascus sanguineus for
           secondary metabolites production

    • Authors: Rashmi Dikshit; Padmavathi Tallapragada
      Abstract: Publication date: Available online 9 March 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Rashmi Dikshit, Padmavathi Tallapragada
      Present study was carried out to develop a potent mutant for enhancing secondary metabolite production from Monascus sanguineus. Ultraviolet (UV) treatment as physical and Ethyl methane sulphonate (EMS) as chemical mutagen was used to cultivate the mutants. All obtained mutants were screened for growth and pigment yield on three different synthetic media namely; potato dextrose agar (PDA), malt glucose peptone agar (MGPA) and Czapek Dox yeast extract Agar (CDYA). MGPA media was found suitable for pigment yield whereas appreciable growth was observed with CDYA. Highest pigment yield was obtained for mutants developed at EMS concentration of 0.6 μg/μL (EMS-3) and UV exposed for seven minutes (UV-4). Exposure to UV for 11 min suppressed the pigment production. However this exposed strain (albino) was found to be an efficient producer of lovastatin with no traces of citrinin alike parental strain. Both EMS-3 and UV-4 mutants had synthesized negligible amount of citrinin, well below regulatory toxic levels. Significant variation was also noticed on the spore morphology of tested strains. Aleuroconidia was observed with albino strain whereas clestothesium along with pigmented ascospores were noticed with UV-4 and EMS-3 mutants. In a nutshell, these strains can be endorsed as nontoxic and safe for human consumption.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.03.001
  • Isolation and molecular characterization of antifungal metabolite
           producing actinomycete from mangrove soil

    • Authors: Mary Sulakshana Palla; Girija Shankar Guntuku; Murali Krishna Kumar Muthyala; Sirisha Pingali; Prafulla Kumar Sahu
      Abstract: Publication date: Available online 6 March 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Mary Sulakshana Palla, Girija Shankar Guntuku, Murali Krishna Kumar Muthyala, Sirisha Pingali, Prafulla Kumar Sahu
      The main object of the present study is to isolate and characterize the actinomycetes from Koringa mangrove soil samples near Kakinada, Andhra Pradesh, India. Isolated actinomycetes were assessed for antagonistic activity against various bacteria and fungi. The potent strain KMFA-1 having activity against dermatophytes Candida albicans and Pectinotrichum llanense was characterized. Based on physiological, morphological characteristics and 16s rRNA gene sequencing the isolated strain was identified as Streptomyces hydrogenans. Extraction was done with different solvents and the activity was evaluated for each solvent extract. The antibiotic that is responsible for activity is found to be highly water soluble. The bioactive metabolite present in crude supernatant was found to be stable at 80 °C for 1 h, 90% activity was retained after boiling at 100 °C for 1 h, but 53.4% activity was reduced after autoclaving (at 121 °C for 15 min). The activity was not lost when the crude supernatant was subjected to wide range of pH (2–10). Furthermore, analytical techniques must be employed to isolate the molecule of interest. The result of present study revealed that the Streptomyces hydrogenans produced an interesting antifungal metabolite.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.02.006
  • Discovery of potential visfatin activators using in silico docking and
           ADME predictions as therapy for type 2 diabetes

    • Authors: Olusola Olalekan Elekofehinti; Oluwamodupe Cecilia Ejelonu; Jean Paul Kamdem; Oluwaseun Benedicta Akinlosotu; Ayodeji Famuti; Damilare Desmond Adebowale; Opeyemi Iwaloye; Yetunde Irinyemi Bulu; Ige Joseph Kade; Joao Batista Teixeira Rocha
      Abstract: Publication date: Available online 6 March 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Olusola Olalekan Elekofehinti, Oluwamodupe Cecilia Ejelonu, Jean Paul Kamdem, Oluwaseun Benedicta Akinlosotu, Ayodeji Famuti, Damilare Desmond Adebowale, Opeyemi Iwaloye, Yetunde Irinyemi Bulu, Ige Joseph Kade, Joao Batista Teixeira Rocha
      Visfatin (Nicotinamide phosphoribosyltransferase) is an adipokine implicated in mediating insulin resistance and exhibiting insulin mimetic effect and therefore represents a druggable target for diabetes therapy. About 3,844 peroxisome proliferator activated receptor gamma (PPARγ) agonists documented in Chembl database were docked with PPARγ and those with binding energy of >−9 kcal/mol having experimental EC50 of 0.1 to 1 nM were selected. The candidate compounds (27) were thereafter docked with visfatin (PDB ID: 4WQ6) using AutodockVina out of which eight compounds that ranked highest in binding energy (when compared with the co-crystallized ligand of visfatin: 3TQ) were selected. Compound 25 exhibited favorable ligand-protein molecular interaction and respected Lipinski’s rule of five and interestingly from the absorption, distribution, metabolism and excretion (ADME)-Toxicity analysis the compound have enhanced pharmacological properties than the current ligand of visfatin.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.02.007
  • In vitro and in vivo anthelmintic activity of pumpkin seeds and
           pomegranate peels extracts against Ascaridia galli

    • Authors: Amer R. Abdel Aziz; Mahmoud R. AbouLaila; Mohammad Aziz; Mosaab A. Omar; Khaled Sultan
      Abstract: Publication date: Available online 12 February 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Amer R. Abdel Aziz, Mahmoud R. AbouLaila, Mohammad Aziz, Mosaab A. Omar, Khaled Sultan
      Pumpkin seeds (Cucurbita pepo) and Pomegranate peel (Punica granatum) have anthelmintic properties. The aim of this study was to compare the anthelmintic efficacy of pumpkin seeds ethanolic extract and pomegranate peel aqueous extract against Ascaridia galli in vitro and in vivo in Baladi chicks. On adult worms, the extracts of the two herbs were compared in vitro at concentrations of 25, 50, and 75 mg/ml with fenbendazole at a concentration of 5 mg/ml. Chicks were infected with Ascaridia galli eggs containing second stage larva and treated with 2000 mg/kg of each of the extracts compared with 100 mg/kg fenbendazole. In vitro, all concentrations of pumpkin seed extract and the concentration of 75 mg/ml pomegranate peel extract exhibited a nearly similar effect to fenbendazole. In vivo, the mortality rate of the worms extracted from the 2000 mg/kg pumpkin seeds extract-treated chicken was non-significantly different from that of fenbendazole for 48 h. While pomegranate peels extract exhibited a lower lethal effect than fenbendazole. The anthelmintic efficacy was dependent on time and concentration. The study presented the anthelmintic efficacy of the pumpkin seeds and pomegranate peel extracts on Ascaridia galli. Pumpkin seed extract was more effective than pomegranate peel extract. Future studies to determine the optimal dose to maximize their effectiveness especially for pumpkin seeds as anthelmintic therapeutic are required.

      PubDate: 2018-04-25T11:56:01Z
      DOI: 10.1016/j.bjbas.2018.02.003
  • Effect of health teaching on post partum minor discomfort

    • Authors: Heba Talla El Ashmawy Shabaan; Yousria Ahmed El Sayed; Gehan Ghonemy
      Abstract: Publication date: Available online 10 January 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Heba Talla El Ashmawy Shabaan, Yousria Ahmed El Sayed, Gehan Ghonemy
      Background postpartum period is a time of vast change for women both physically and psychologically. During this period, women needed to information regarding minor discomforts and how to deal with them. Aim Evaluate the effect of health teaching on women experience of minor discomfort during postpartum period. Design Quesi experimental (pre and posttest one group) design was selected for this study. Sample A convenience sample of 150 subjects was selected according to certain criteria Setting postpartum unit at Maternity University Hospital, Cairo Governorate Tool: Semi -structured Interviewing sheet, maternal knowledge regarding postpartum minor discomforts follow up tool. Results Subjects age ranged from 20 to 40 years with 44% completed secondary school education, 9.3% reached high level of education, also, the study conveyed a level of improvement regarding breast engorgement, after pain, urinary retention, constipation and episiotomy pain. Sixty four point seven of subjects mention that they weren’t aware of expected minor discomforts during postpartum period before health teaching was given. After the teaching, only 0.7% of subjects were not aware of postpartum minor discomforts. Conclusion Teaching helped to improve the women's knowledge regarding postpartum discomforts. Recommendations Health educational package on postpartum discomforts should be given on discharge should be written in clear and comprehensive explanation supported by drawing pamphlets especially for illiterate one

      PubDate: 2018-01-10T07:43:08Z
      DOI: 10.1016/j.bjbas.2017.10.004
  • The protective effect of grape seed and ginkgo biloba against
           hepatotoxicity induced by the antidysrhythmic drug “amiodarone” in
           male albino rats

    • Authors: Manal Abdul-Hamid; Sanaa Reda Galaly; Hanaa Mahmoud; Fatma Mostafa
      Abstract: Publication date: Available online 28 December 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Manal Abdul-Hamid, Sanaa Reda Galaly, Hanaa Mahmoud, Fatma Mostafa
      Amiodarone was an orally effective antiarrhythmic drug widely used throughout the world, had long-term administration side effects such as hepatotoxicity. The actions of two antioxidants; grape seed and ginkgo biloba on the extent of tissue damage in amiodarone-induced hepatotoxicity were elucidated in this study. We equally divided thirty six albino rats into six groups given doses by gastric tube daily for 8 weeks as follow; the 1st group (G1) served as an untreated control group under the same laboratory conditions and was given distilled water, the 2nd group (G2) grape seed-treated group that received (100 mg/kg/day), the 3rd group (G3) ginkgo biloba-treated group that received (100 mg/kg/day), the 4th group (G4) amiodarone-treated group that received (40 mg/kg/day), the 5th group (G5) received amiodarone parallel with grape seed at the same time and the 6th group (G6) received amiodarone parallel with ginkgo biloba at the same time. The current histological study revealed that amiodarone caused marked change in the liver including degeneration, proliferation of bile duct, inflammatory cells infiltration and fatty changes of hepatocytes in addition to deposition of collagen fibers in the hepatic tissue moreover, ultra-structural observations in the liver including vacuolation, fibrosis and pyknotic nuclei. In addition, histochemical study revealed depletion of glycogen and comet assay revealed marked of DNA damage. Treatment with the two used antioxidants reduced the extent of liver damage induced by amiodarone as indicated by decreased Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) activities. These antioxidants ameliorated the histopathological, histochemical and ultrastructure alternations of the liver tissue. In conclusion, grape seed was markedly effective than ginkgo biloba in protecting rats against amiodarone.

      PubDate: 2018-01-10T07:43:08Z
      DOI: 10.1016/j.bjbas.2017.12.001
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