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ENGINEERING (1240 journals)                  1 2 3 4 5 6 7 | Last

Showing 1 - 200 of 1205 Journals sorted alphabetically
3 Biotech     Open Access   (Followers: 8)
3D Research     Hybrid Journal   (Followers: 20)
AAPG Bulletin     Hybrid Journal   (Followers: 8)
AASRI Procedia     Open Access   (Followers: 14)
Abstract and Applied Analysis     Open Access   (Followers: 3)
Aceh International Journal of Science and Technology     Open Access   (Followers: 2)
ACS Nano     Full-text available via subscription   (Followers: 264)
Acta Geotechnica     Hybrid Journal   (Followers: 7)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 6)
Acta Polytechnica : Journal of Advanced Engineering     Open Access   (Followers: 3)
Acta Scientiarum. Technology     Open Access   (Followers: 3)
Acta Universitatis Cibiniensis. Technical Series     Open Access  
Active and Passive Electronic Components     Open Access   (Followers: 7)
Adaptive Behavior     Hybrid Journal   (Followers: 11)
Adıyaman Üniversitesi Mühendislik Bilimleri Dergisi     Open Access  
Adsorption     Hybrid Journal   (Followers: 4)
Advanced Engineering Forum     Full-text available via subscription   (Followers: 7)
Advanced Science     Open Access   (Followers: 5)
Advanced Science Focus     Free   (Followers: 5)
Advanced Science Letters     Full-text available via subscription   (Followers: 9)
Advanced Science, Engineering and Medicine     Partially Free   (Followers: 7)
Advanced Synthesis & Catalysis     Hybrid Journal   (Followers: 18)
Advances in Calculus of Variations     Hybrid Journal   (Followers: 2)
Advances in Catalysis     Full-text available via subscription   (Followers: 5)
Advances in Complex Systems     Hybrid Journal   (Followers: 6)
Advances in Engineering Software     Hybrid Journal   (Followers: 27)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 15)
Advances in Fuzzy Systems     Open Access   (Followers: 5)
Advances in Geosciences (ADGEO)     Open Access   (Followers: 13)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 21)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 23)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 9)
Advances in Natural Sciences: Nanoscience and Nanotechnology     Open Access   (Followers: 29)
Advances in Operations Research     Open Access   (Followers: 12)
Advances in OptoElectronics     Open Access   (Followers: 5)
Advances in Physics Theories and Applications     Open Access   (Followers: 13)
Advances in Polymer Science     Hybrid Journal   (Followers: 43)
Advances in Porous Media     Full-text available via subscription   (Followers: 5)
Advances in Remote Sensing     Open Access   (Followers: 43)
Advances in Science and Research (ASR)     Open Access   (Followers: 4)
Aerobiologia     Hybrid Journal   (Followers: 2)
African Journal of Science, Technology, Innovation and Development     Hybrid Journal   (Followers: 6)
AIChE Journal     Hybrid Journal   (Followers: 35)
Ain Shams Engineering Journal     Open Access   (Followers: 5)
Akademik Platform Mühendislik ve Fen Bilimleri Dergisi     Open Access   (Followers: 1)
Alexandria Engineering Journal     Open Access   (Followers: 1)
AMB Express     Open Access   (Followers: 1)
American Journal of Applied Sciences     Open Access   (Followers: 26)
American Journal of Engineering and Applied Sciences     Open Access   (Followers: 10)
American Journal of Engineering Education     Open Access   (Followers: 9)
American Journal of Environmental Engineering     Open Access   (Followers: 16)
American Journal of Industrial and Business Management     Open Access   (Followers: 23)
Analele Universitatii Ovidius Constanta - Seria Chimie     Open Access  
Annals of Combinatorics     Hybrid Journal   (Followers: 3)
Annals of Pure and Applied Logic     Open Access   (Followers: 2)
Annals of Regional Science     Hybrid Journal   (Followers: 7)
Annals of Science     Hybrid Journal   (Followers: 7)
Antarctic Science     Hybrid Journal   (Followers: 1)
Applicable Algebra in Engineering, Communication and Computing     Hybrid Journal   (Followers: 2)
Applicable Analysis: An International Journal     Hybrid Journal   (Followers: 1)
Applied Catalysis A: General     Hybrid Journal   (Followers: 6)
Applied Catalysis B: Environmental     Hybrid Journal   (Followers: 18)
Applied Clay Science     Hybrid Journal   (Followers: 5)
Applied Computational Intelligence and Soft Computing     Open Access   (Followers: 11)
Applied Magnetic Resonance     Hybrid Journal   (Followers: 4)
Applied Nanoscience     Open Access   (Followers: 8)
Applied Network Science     Open Access   (Followers: 3)
Applied Numerical Mathematics     Hybrid Journal   (Followers: 5)
Applied Physics Research     Open Access   (Followers: 5)
Applied Sciences     Open Access   (Followers: 3)
Applied Spatial Analysis and Policy     Hybrid Journal   (Followers: 4)
Arabian Journal for Science and Engineering     Hybrid Journal   (Followers: 5)
Archives of Computational Methods in Engineering     Hybrid Journal   (Followers: 5)
Archives of Foundry Engineering     Open Access  
Archives of Thermodynamics     Open Access   (Followers: 8)
Arkiv för Matematik     Hybrid Journal   (Followers: 1)
ASEE Prism     Full-text available via subscription   (Followers: 3)
Asia-Pacific Journal of Science and Technology     Open Access  
Asian Engineering Review     Open Access  
Asian Journal of Applied Science and Engineering     Open Access   (Followers: 1)
Asian Journal of Applied Sciences     Open Access   (Followers: 2)
Asian Journal of Biotechnology     Open Access   (Followers: 8)
Asian Journal of Control     Hybrid Journal  
Asian Journal of Current Engineering & Maths     Open Access  
Asian Journal of Technology Innovation     Hybrid Journal   (Followers: 8)
Assembly Automation     Hybrid Journal   (Followers: 2)
at - Automatisierungstechnik     Hybrid Journal   (Followers: 1)
ATZagenda     Hybrid Journal  
ATZextra worldwide     Hybrid Journal  
Australasian Physical & Engineering Sciences in Medicine     Hybrid Journal   (Followers: 1)
Australian Journal of Multi-Disciplinary Engineering     Full-text available via subscription   (Followers: 2)
Autonomous Mental Development, IEEE Transactions on     Hybrid Journal   (Followers: 9)
Avances en Ciencias e Ingeniería     Open Access  
Balkan Region Conference on Engineering and Business Education     Open Access   (Followers: 1)
Bangladesh Journal of Scientific and Industrial Research     Open Access  
Basin Research     Hybrid Journal   (Followers: 5)
Batteries     Open Access   (Followers: 6)
Bautechnik     Hybrid Journal   (Followers: 1)
Bell Labs Technical Journal     Hybrid Journal   (Followers: 26)
Beni-Suef University Journal of Basic and Applied Sciences     Open Access   (Followers: 4)
BER : Manufacturing Survey : Full Survey     Full-text available via subscription   (Followers: 1)
BER : Motor Trade Survey     Full-text available via subscription  
BER : Retail Sector Survey     Full-text available via subscription   (Followers: 1)
BER : Retail Survey : Full Survey     Full-text available via subscription   (Followers: 1)
BER : Survey of Business Conditions in Manufacturing : An Executive Summary     Full-text available via subscription   (Followers: 2)
BER : Survey of Business Conditions in Retail : An Executive Summary     Full-text available via subscription   (Followers: 3)
Bhakti Persada : Jurnal Aplikasi IPTEKS     Open Access  
Bharatiya Vaigyanik evam Audyogik Anusandhan Patrika (BVAAP)     Open Access   (Followers: 1)
Biofuels Engineering     Open Access   (Followers: 1)
Biointerphases     Open Access   (Followers: 1)
Biomaterials Science     Full-text available via subscription   (Followers: 10)
Biomedical Engineering     Hybrid Journal   (Followers: 15)
Biomedical Engineering and Computational Biology     Open Access   (Followers: 13)
Biomedical Engineering Letters     Hybrid Journal   (Followers: 5)
Biomedical Engineering, IEEE Reviews in     Full-text available via subscription   (Followers: 19)
Biomedical Engineering, IEEE Transactions on     Hybrid Journal   (Followers: 35)
Biomedical Engineering: Applications, Basis and Communications     Hybrid Journal   (Followers: 5)
Biomedical Microdevices     Hybrid Journal   (Followers: 9)
Biomedical Science and Engineering     Open Access   (Followers: 4)
Biomedizinische Technik - Biomedical Engineering     Hybrid Journal  
Biomicrofluidics     Open Access   (Followers: 4)
BioNanoMaterials     Hybrid Journal   (Followers: 2)
Biotechnology Progress     Hybrid Journal   (Followers: 39)
Boletin Cientifico Tecnico INIMET     Open Access  
Botswana Journal of Technology     Full-text available via subscription   (Followers: 1)
Boundary Value Problems     Open Access   (Followers: 1)
Brazilian Journal of Science and Technology     Open Access   (Followers: 2)
Broadcasting, IEEE Transactions on     Hybrid Journal   (Followers: 10)
Bulletin of Canadian Petroleum Geology     Full-text available via subscription   (Followers: 13)
Bulletin of Engineering Geology and the Environment     Hybrid Journal   (Followers: 14)
Bulletin of the Crimean Astrophysical Observatory     Hybrid Journal  
Cahiers, Droit, Sciences et Technologies     Open Access  
Calphad     Hybrid Journal  
Canadian Geotechnical Journal     Hybrid Journal   (Followers: 31)
Canadian Journal of Remote Sensing     Full-text available via subscription   (Followers: 42)
Case Studies in Engineering Failure Analysis     Open Access   (Followers: 6)
Case Studies in Thermal Engineering     Open Access   (Followers: 5)
Catalysis Communications     Hybrid Journal   (Followers: 6)
Catalysis Letters     Hybrid Journal   (Followers: 2)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 7)
Catalysis Science and Technology     Free   (Followers: 8)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 3)
Catalysis Today     Hybrid Journal   (Followers: 7)
CEAS Space Journal     Hybrid Journal   (Followers: 2)
Cellular and Molecular Neurobiology     Hybrid Journal   (Followers: 3)
Central European Journal of Engineering     Hybrid Journal  
CFD Letters     Open Access   (Followers: 6)
Chaos : An Interdisciplinary Journal of Nonlinear Science     Hybrid Journal   (Followers: 2)
Chaos, Solitons & Fractals     Hybrid Journal   (Followers: 3)
Chinese Journal of Catalysis     Full-text available via subscription   (Followers: 2)
Chinese Journal of Engineering     Open Access   (Followers: 2)
Chinese Science Bulletin     Open Access   (Followers: 1)
Ciencia e Ingenieria Neogranadina     Open Access  
Ciencia en su PC     Open Access   (Followers: 1)
Ciencias Holguin     Open Access   (Followers: 2)
CienciaUAT     Open Access   (Followers: 1)
Cientifica     Open Access  
CIRP Annals - Manufacturing Technology     Full-text available via subscription   (Followers: 11)
CIRP Journal of Manufacturing Science and Technology     Full-text available via subscription   (Followers: 13)
City, Culture and Society     Hybrid Journal   (Followers: 20)
Clay Minerals     Full-text available via subscription   (Followers: 10)
Clean Air Journal     Full-text available via subscription   (Followers: 1)
Coal Science and Technology     Full-text available via subscription   (Followers: 3)
Coastal Engineering     Hybrid Journal   (Followers: 11)
Coastal Engineering Journal     Hybrid Journal   (Followers: 5)
Coatings     Open Access   (Followers: 4)
Cogent Engineering     Open Access   (Followers: 2)
Cognitive Computation     Hybrid Journal   (Followers: 4)
Color Research & Application     Hybrid Journal   (Followers: 2)
COMBINATORICA     Hybrid Journal  
Combustion Theory and Modelling     Hybrid Journal   (Followers: 14)
Combustion, Explosion, and Shock Waves     Hybrid Journal   (Followers: 13)
Communications Engineer     Hybrid Journal   (Followers: 1)
Communications in Numerical Methods in Engineering     Hybrid Journal   (Followers: 2)
Components, Packaging and Manufacturing Technology, IEEE Transactions on     Hybrid Journal   (Followers: 28)
Composite Interfaces     Hybrid Journal   (Followers: 7)
Composite Structures     Hybrid Journal   (Followers: 272)
Composites Part A : Applied Science and Manufacturing     Hybrid Journal   (Followers: 209)
Composites Part B : Engineering     Hybrid Journal   (Followers: 244)
Composites Science and Technology     Hybrid Journal   (Followers: 182)
Comptes Rendus Mécanique     Full-text available via subscription   (Followers: 2)
Computation     Open Access  
Computational Geosciences     Hybrid Journal   (Followers: 15)
Computational Optimization and Applications     Hybrid Journal   (Followers: 7)
Computational Science and Discovery     Full-text available via subscription   (Followers: 2)
Computer Applications in Engineering Education     Hybrid Journal   (Followers: 8)
Computer Science and Engineering     Open Access   (Followers: 19)
Computers & Geosciences     Hybrid Journal   (Followers: 30)
Computers & Mathematics with Applications     Full-text available via subscription   (Followers: 8)
Computers and Electronics in Agriculture     Hybrid Journal   (Followers: 5)
Computers and Geotechnics     Hybrid Journal   (Followers: 11)
Computing and Visualization in Science     Hybrid Journal   (Followers: 6)
Computing in Science & Engineering     Full-text available via subscription   (Followers: 33)
Conciencia Tecnologica     Open Access  
Concurrent Engineering     Hybrid Journal   (Followers: 3)
Continuum Mechanics and Thermodynamics     Hybrid Journal   (Followers: 8)
Control and Dynamic Systems     Full-text available via subscription   (Followers: 9)
Control Engineering Practice     Hybrid Journal   (Followers: 43)
Control Theory and Informatics     Open Access   (Followers: 8)
Corrosion Science     Hybrid Journal   (Followers: 25)

        1 2 3 4 5 6 7 | Last

Journal Cover Beni-Suef University Journal of Basic and Applied Sciences
  [4 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2314-8535
   Published by Elsevier Homepage  [3175 journals]
  • Effect of health teaching on post partum minor discomfort

    • Authors: Heba Talla El Ashmawy Shabaan; Yousria Ahmed El Sayed; Gehan Ghonemy
      Abstract: Publication date: Available online 10 January 2018
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Heba Talla El Ashmawy Shabaan, Yousria Ahmed El Sayed, Gehan Ghonemy
      Background postpartum period is a time of vast change for women both physically and psychologically. During this period, women needed to information regarding minor discomforts and how to deal with them. Aim Evaluate the effect of health teaching on women experience of minor discomfort during postpartum period. Design Quesi experimental (pre and posttest one group) design was selected for this study. Sample A convenience sample of 150 subjects was selected according to certain criteria Setting postpartum unit at Maternity University Hospital, Cairo Governorate Tool: Semi -structured Interviewing sheet, maternal knowledge regarding postpartum minor discomforts follow up tool. Results Subjects age ranged from 20 to 40 years with 44% completed secondary school education, 9.3% reached high level of education, also, the study conveyed a level of improvement regarding breast engorgement, after pain, urinary retention, constipation and episiotomy pain. Sixty four point seven of subjects mention that they weren’t aware of expected minor discomforts during postpartum period before health teaching was given. After the teaching, only 0.7% of subjects were not aware of postpartum minor discomforts. Conclusion Teaching helped to improve the women's knowledge regarding postpartum discomforts. Recommendations Health educational package on postpartum discomforts should be given on discharge should be written in clear and comprehensive explanation supported by drawing pamphlets especially for illiterate one

      PubDate: 2018-01-10T07:43:08Z
      DOI: 10.1016/j.bjbas.2017.10.004
  • The protective effect of grape seed and ginkgo biloba against
           hepatotoxicity induced by the antidysrhythmic drug “amiodarone” in
           male albino rats

    • Authors: Manal Abdul-Hamid; Sanaa Reda Galaly; Hanaa Mahmoud; Fatma Mostafa
      Abstract: Publication date: Available online 28 December 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Manal Abdul-Hamid, Sanaa Reda Galaly, Hanaa Mahmoud, Fatma Mostafa
      Amiodarone was an orally effective antiarrhythmic drug widely used throughout the world, had long-term administration side effects such as hepatotoxicity. The actions of two antioxidants; grape seed and ginkgo biloba on the extent of tissue damage in amiodarone-induced hepatotoxicity were elucidated in this study. We equally divided thirty six albino rats into six groups given doses by gastric tube daily for 8 weeks as follow; the 1st group (G1) served as an untreated control group under the same laboratory conditions and was given distilled water, the 2nd group (G2) grape seed-treated group that received (100 mg/kg/day), the 3rd group (G3) ginkgo biloba-treated group that received (100 mg/kg/day), the 4th group (G4) amiodarone-treated group that received (40 mg/kg/day), the 5th group (G5) received amiodarone parallel with grape seed at the same time and the 6th group (G6) received amiodarone parallel with ginkgo biloba at the same time. The current histological study revealed that amiodarone caused marked change in the liver including degeneration, proliferation of bile duct, inflammatory cells infiltration and fatty changes of hepatocytes in addition to deposition of collagen fibers in the hepatic tissue moreover, ultra-structural observations in the liver including vacuolation, fibrosis and pyknotic nuclei. In addition, histochemical study revealed depletion of glycogen and comet assay revealed marked of DNA damage. Treatment with the two used antioxidants reduced the extent of liver damage induced by amiodarone as indicated by decreased Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) activities. These antioxidants ameliorated the histopathological, histochemical and ultrastructure alternations of the liver tissue. In conclusion, grape seed was markedly effective than ginkgo biloba in protecting rats against amiodarone.

      PubDate: 2018-01-10T07:43:08Z
      DOI: 10.1016/j.bjbas.2017.12.001
  • Biomembrane stabilization and antiulcerogenic properties of aqueous leaf
           extract of Gossypium barbadense L. (Malvaceae)

    • Authors: S. Sabiu; E.O. Ajani; A.A. Ajao; T.O. Sunmonu; A.S. Ibraheem; R. Ibrahim; H. Mustapha; A.O. Adekeye
      Pages: 301 - 309
      Abstract: Publication date: December 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences, Volume 6, Issue 4
      Author(s): S. Sabiu, E.O. Ajani, A.A. Ajao, T.O. Sunmonu, A.S. Ibraheem, R. Ibrahim, H. Mustapha, A.O. Adekeye
      Gossypium spp. belong to a class of botanicals with global therapeutic applications against a number of disorders including ulcers. This study evaluated the membrane stabilization and detoxification potential of aqueous leaf extract of Gossypium barbadense L. (Malvaceae) in indomethacin-induced oxidative gastric ulceration in Wistar rats. The ulcerated rats were orally pretreated with the extract and esomeprazole for 4weeks. Gastric function and antioxidative parameters were thereafter evaluated. The indomethacin-mediated significant elevations in the ulcer index, gastric volume, pepsin activity and mucosal level of malondialdehyde were dosedependently attenuated in the extract-treated animals. The extract also significantly modulated and improved the pH, mucin content, glutathione (reduced) as well as gastric activities of superoxide dismutase and catalase in the ulcerated rats. These improvements may be ascribed to the antioxidant and membrane stabilization activities of the extract which are attributable to its active metabolites as revealed by the analytical chromatogram. The observed effects compared favorably with that of esomeprazole and are suggestive of the capability of the extract to prevent mucosal damage and preserve gastric functions as evidently supported by the macroscopical appearance of the stomachs and the % ulcer inhibitory values. Conclusively, the overall data from the present findings suggest that the aqueous leaf extract of G. barbadense could prevent indomethacin-mediated oxidative gastric ulceration via fortification of antioxidant defense mechanisms.

      PubDate: 2017-12-27T04:12:03Z
      DOI: 10.1016/j.bjbas.2017.05.007
  • Hepatoprotective activity of methanolic extracts of Lactuca runcinata DC
           and Gyrocarpus asiaticus Willd.

    • Authors: Lakshmi Kanta Kanthal; K. Satyavathi; P. Bhojaraju; Manna Prabal Kumar
      Pages: 321 - 325
      Abstract: Publication date: December 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences, Volume 6, Issue 4
      Author(s): Lakshmi Kanta Kanthal, K. Satyavathi, P. Bhojaraju, Manna Prabal Kumar

      PubDate: 2017-12-27T04:12:03Z
      DOI: 10.1016/j.bjbas.2017.05.002
  • Applying decision-making techniques to Civil Engineering Projects

    • Authors: Fam F. Abdel-malak; Usama H. Issa; Yehia H. Miky; Emad A. Osman
      Pages: 326 - 331
      Abstract: Publication date: December 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences, Volume 6, Issue 4
      Author(s): Fam F. Abdel-malak, Usama H. Issa, Yehia H. Miky, Emad A. Osman
      Multi-Criteria Decision-Making (MCDM) techniques are found to be useful tools in project managers’ hands to overcome decision-making (DM) problems in Civil Engineering Projects (CEPs). The main contribution of this paper includes selecting and studying the popular MCDM techniques that uses different and wide ranges of data types in CEPs. A detailed study including advantages and pitfalls of using the Analytic Hierarchy Process (AHP) and Fuzzy Technique for Order of Preference by Similarity to Ideal Solution (Fuzzy TOPSIS) is introduced. Those two techniques are selected for the purpose of forming a package that covers most available data types in CEPs. The results indicated that AHP has a structure which simplifies complicated problems, while Fuzzy TOPSIS uses the advantages of linguistic variables to solve the issue of undocumented data and ill-defined problems. Furthermore, AHP is a simple technique that depends on pairwise comparisons of factors and natural attributes, beside it is preferable for widely spread hierarchies. On the other hand, Fuzzy TOPSIS needs more information but works well for the one-tier decision tree as well as it shows more flexibility to work in fuzzy environments. The two techniques have the facility to be integrated and combined in a new module to support most of the decisions required in CEPs.

      PubDate: 2017-12-27T04:12:03Z
      DOI: 10.1016/j.bjbas.2017.05.004
  • Molluscicidal activity of Bacillus thuringiensis strains against
           Biomphalaria alexandrina snails

    • Authors: Amany M. Abd El-Ghany; Nesreen M. Abd El-Ghany
      Pages: 391 - 393
      Abstract: Publication date: December 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences, Volume 6, Issue 4
      Author(s): Amany M. Abd El-Ghany, Nesreen M. Abd El-Ghany
      Schistosomiasis is a parasitic disease transmitted to man and different warm blooded animals by means of snails. Great effort has been made to control the transmission of the disease by many strategies. Consequently, the utilization of particular molluscicides is viewed as a standout amongst the best measures for molluscs control. Recently, microbial pathogen used as non-traditional molluscicides which have attracted significant research attention due to the increasing, worldwide development of resistance to chemical molluscicides in molluscs populations. The present work aimed to study the molluscicidal impacts of eleven isolates of Bacillus thuringiensis which were isolated from soils of six Egyptian governorates toward Biomphalaria alexandrina snails. Results showed that, B. thuringiensis provides an effective biological control agent against B. alexandrina snails. Out of the tested isolates, four isolates; Qalyubia, Asyut 1, Qena and North Sinai 2 isolates show high-level molluscicidal activity. The obtained results indicated that LC50 and LC90 values were ranged between 133.27–457.74mg/mL and 270.32–781.05mg/mL, respectively. The most noteworthy molluscicidal impact was displayed by Qalyubia isolate which isolated from Qalyubia governorate with mortality rate extended from 20% to100% at five treatment concentrations of 100–500mg/mL. The LC50 and LC90 values for Qalyubia isolate were 133.27mg/mL and 270.32mg/mL, respectively.

      PubDate: 2017-12-27T04:12:03Z
      DOI: 10.1016/j.bjbas.2017.05.003
  • Ulva lactuca hydroethanolic extract suppresses experimental arthritis via
           its anti-inflammatory and antioxidant activities

    • Authors: Osama M. Ahmed; Hanan A. Soliman; Basant Mahmoud; Randa R. Gheryany
      Pages: 394 - 408
      Abstract: Publication date: December 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences, Volume 6, Issue 4
      Author(s): Osama M. Ahmed, Hanan A. Soliman, Basant Mahmoud, Randa R. Gheryany
      This study was designed to evaluate the effect of Ulva lactuca hydroethanolic extract on rheumatoid arthritis in male Wistar rats. Rheumatoid arthritis was induced in rats by subcutaneous injection of 200µl Freund’s complete adjuvant into a footpad of the right hind leg of male rats at two consecutive days. Arthritic rats were orally treated with Ulva lactuca hydroethanolic extract at dose level of 100mg/kg b.wt /day for 1, 2 and 3weeks and were compared with corresponding arthritic control at the same periods. The increased right hind paw circumference at tarsal pad, deleteriously affected ankle joint histological architecture, articular inflammatory cell infiltration and focal necrosis in arthritic rats were counteracted by hydroethanolic extract treatment at the three tested periods. Elevated leukocytes count in arthritic rats connected with changes of spleen and thymus histological architecture, extramedullary megakaryocytes, lymphoblasts activation and mitotic figures were significantly improved by Ulva lactuca hydroethanolic extract treatment at the three tested peroids. The elevated rheumatoid factor (RF), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-α), interleukin-17 (IL-17) and interleukin-1beta (IL-1β) levels and the lowered interleukin-4 (IL-4) level in arthritic rats were markedly ameliorated as a result of Ulva lactuca administration. The lowered glutathione level and glutathione peroxidase, glutathione reductase and superoxide dismutase activities as well as the elevated lipid peroxides level in serum of arthritic rats were potentially alleviated as a result of Ulva lactuca treatment. In conclusion, Ulva lactuca could have anti-arthritic efficacies which may be mediated via its anti-inflammatory and anti-oxidant potentials.

      PubDate: 2017-12-27T04:12:03Z
      DOI: 10.1016/j.bjbas.2017.04.013
  • Design and combinatorial library generation of 1H 1,4 benzodiazepine 2,5
           diones as photosystem-II inhibitors: A public QSAR approach

    • Authors: Purusottam Banjare; Jagadish Singh; Partha Pratim Roy
      Pages: 219 - 231
      Abstract: Publication date: September 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences, Volume 6, Issue 3
      Author(s): Purusottam Banjare, Jagadish Singh, Partha Pratim Roy
      Exponential rise in the population around the word increased the demand of food grains/crops with limited expansion of the agricultural land. To meet the demand, generation of new herbicidal agents is of primary need for the manufacturing firm. In silico tool like QSAR is one of the regularly used in designing newer compounds along with wet experiment. Photosystem-II (PS-II) regarded as one of the major target for the herbicidal agents. With this aim in the present study a series of 1H, 1,4 benzodiazepine 2,5-dione analogues as herbicidal (PS-II inhibitors) agents were subjected to QSAR analysis using 2D PaDEL descriptors (open source). Two different splitting techniques namely, kennard stone based and k-means clustering splitting were used to divide the whole data set and GFA based on MAE criteria was used a statistical method to develop a model to investigate the physicochemical and structural requirement of potential PS-II inhibitors. All the models are statistically robust both internally and externally (Q2: 0.540–0.693, R2 pred: 0.722–0.810). The activity is mostly affected by polarizabilities, electro negativities as well as substituents at the phenyl ring. Based on the results, a library of compounds was generated using SmiLib v2.0 tool (open source) and better predicted inside applicability domain compounds were identified by applying three different applicability domain (AD) approaches. Therefore the developed public QSAR models may be helpful for the scientific community for the further research.

      PubDate: 2017-09-15T14:59:21Z
      DOI: 10.1016/j.bjbas.2017.04.003
  • Ultrasound assisted one pot expeditious synthesis of new
           pyrido[2,3-d]pyrimidine analogues using mild and inexpensive
           4-dimethylaminopyridine (DMAP) catalyst

    • Authors: Ajmal R. Bhat; Gowhar A. Naikoo; Israr Ul Hassan; Rajendra S. Dongra; Tabassum Ara
      Pages: 238 - 246
      Abstract: Publication date: September 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences, Volume 6, Issue 3
      Author(s): Ajmal R. Bhat, Gowhar A. Naikoo, Israr Ul Hassan, Rajendra S. Dongra, Tabassum Ara
      The one-pot three-component reaction for the synthesis of pyrido[2,3-d]pyrimidine derivatives has been reported via initial Knoevenagel, subsequent addition and final heterocyclization of substituted aromatic aldehydes, cyanoacetamide and 6-aminouracil in N,N-dimethylformamide (DMF) solvent using 4-dimethylaminopyridine (DMAP) as new organocatalyst under ultrasound irradiation. The results showed that a series of aromatic aldehydes were successfully used to prepare the targeted pyrido[2,3-d]pyrimidine derivatives with good to excellent yields (81–93%) and there is no major effect on the yield of product by electron donating/withdrawing substituents. Short reaction time, environment friendly procedure, excellent yields, inexpensive and readily available catalyst are the advantages of this procedure. All synthesized compounds were characterized by IR, 1HNMR, 13CNMR and mass spectral data.

      PubDate: 2017-09-15T14:59:21Z
      DOI: 10.1016/j.bjbas.2017.04.005
  • Uncommon clinical presentation of oral malignant melanoma

    • Authors: Maha M Mahmoud; Marwa Madi; Raneem Gamal
      Abstract: Publication date: Available online 6 December 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Maha M Mahmoud, Marwa Madi, Raneem Gamal
      Malignant melanoma is one of the most lethal skin cancer due its high capability for metastasis. Its incidence has shown a dramatic increase over the past few decades. Primary oral melanoma is uncommon neoplasm, it can be present at any site in the oral cavity, with more frequent occurrence at the hard palate and maxillary alveolar mucosa. The prognosis of primary oral melanoma is extremely poor especially in advanced stage. The case presented here provides an example of how dental clinician have a major role in identifying malignant melanoma in any suspicious proliferating interdentally originated mass with partially pigmented area.

      PubDate: 2017-12-27T04:12:03Z
      DOI: 10.1016/j.bjbas.2017.11.003
  • Molecular docking and quantitative structure-activity relationship study
           of anticonvulsant activity of aminobenzothiazole derivatives

    • Authors: Usman Abdulfatai; Adamu Uzairu; Sani Uba
      Abstract: Publication date: Available online 23 November 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Usman Abdulfatai, Adamu Uzairu, Sani Uba
      In silico studies which include Quantitative structure-activity relationship (QSAR) and molecular docking studies were carried out on the 37 amino-benzothiazole derivatives (anticonvulsant agents). Genetic function approximation (GFA) of Material studio software version 8 was used to perform the QSAR study while Autodock vina version 4.0 of Pyrx software was used to perform the molecular docking of all the anticonvulsant agents. The high value of the correlation coefficient (R2) of 0.961 and the R2pred = 0.925 indicated that the model was satisfactory. Molecular docking analyses with Gamma-aminobutyric acid aminotransferases (GABAAT) revealed that aminobenzothiazole derivatives (anticonvulsant agents) with the best binding affinity was found to be −9.1 kcal/mol. The proposed model has good stability, robustness, and predictability on verifying with internal and external validation. The physicochemical parameters are to be considered when improving the inhibitory activities of the aminobenzothiazole derivatives against an enzyme that causes epilepsy (GABAAT).

      PubDate: 2017-12-27T04:12:03Z
      DOI: 10.1016/j.bjbas.2017.11.002
  • Epidemiological determinants correlating hepatitis C and Schistosomiasis
           mansoni in one of Upper Egypt governorates

    • Authors: Samah S. Abdel Gawad; Enas Yahia Abu-Sarea; Lamiaa Saleh
      Abstract: Publication date: Available online 22 November 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Samah S. Abdel Gawad, Enas Yahia Abu-Sarea, Lamiaa Saleh
      Schistosomiasis and hepatitis C virus (HCV) are endemic diseases with high prevalence in Africa especially in Egypt. Many sociodemographic and behavioral related determinants were implicated to be associated with schistosomiasis, HCV or coinfection. Recently, polymerase chain reaction (PCR) is used as a diagnostic tool as it is a sensitive and a specific method especially in early stage of infection. But, diagnosis of S. mansoni is depending on microscopic examination remains the most widely used direct diagnostic method in endemic area. The current study was carried out to determine the prevalence of schistosomiasis mansoni, HCV and confection if any among the studied population, to identify any associated factors for schistosomiasis mansoni, HCV or coinfection if any. A descriptive cross sectional study was conducted on 400 participants, inhabitants in Beni-Suef Governorate, Upper Egypt. The studied population was screened for both schistosomiasis mansoni and HCV. They were subjected to fulfill a well-structured field tested interviewing questionnaire focusing on many suspected associated factors. Moreover, testing the performance characteristics of the used techniques was determined. The prevalence of schistosomiasis mansoni was (2.8%) and HCV was (42.5%) among the studied subjects. The study highlights on many behavioral and sociodemographic determinants significantly associated with HCV infection such as home crowding index, shaving at the community barber, sharing razors within the family, delivery at home and circumcision outside the health settings. Also, the study revealed that there are certain determinants associated with both schistosomiasis mansoni and HCV infection such as blood transfusion and liver cirrhosis. Studying the linked determinates with schistosomisis and HCV is the cornerstone to plan and implement a preventive strategy in the Upper Egypt. Thus, further studying the associated environmental determinants in relation to schistosoimasis, HCV and coinfection is recommended in the Upper Egypt.

      PubDate: 2017-12-27T04:12:03Z
      DOI: 10.1016/j.bjbas.2017.10.008
  • Amelioration of anaphylaxis, mast cell degranulation and bronchospasm by
           Euphorbia hirta L. extracts in experimental animals

    • Authors: Ghanshyam Parmar; Kilambi Pundarikakshudu; R. Balaraman; Girish Sailor
      Abstract: Publication date: Available online 9 November 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Ghanshyam Parmar, Kilambi Pundarikakshudu, R. Balaraman, Girish Sailor
      The current investigation was aimed to assess anti-anaphylactic, mast cell stabilizing and anti-asthmatic activity of methanol and aqueous extract of Euphorbia hirta (Euphorbiaceae) on experimental animals. Anaphylaxis was induced by administration of horse serum and triple antigen vaccine subcutaneously in albino Wistar rats. Extracts of E. hirta (EH) were administered to the rats in dose of 250 and 500 mg/kg b.w. orally for 14 days. At the end of treatment, asthma score was measured and various blood parameters like differential count (DC), total WBC count and IgE were estimated. Interleukin (IL)-4, IL-5 and tumour necrosis factor (TNF)-α were measured by ELISA commercial kit from Broncho alveolar lavage fluid (BALF). Histopathological changes of lungs were observed. Anti-asthmatic activity of extracts of EH was also studied on histamine-induced bronchospasm in guinea pigs. In vitro mast cell stabilizing activity of extracts was evaluated on compound 48/80 challenged rat intestinal mesenteric mast cells. The treatment with extracts of EH produced significant decrease in asthma score and they also brought to normalcy the increased total WBC, DC counts, serum IgE, TNF-α, IL-4 and IL-5 in BALF. The histopathological study further supported the protective effect of EH extracts. The pre-treatment with extracts of EH displayed significant reduction in degranulation of mesenteric mast cell numbers. The treatment with extracts of EH significantly increased in time of pre-convulsive dyspnoea (PCD). Thus, these findings concluded that E. hirta could be effectively used in the treatment of anaphylaxis and asthma.

      PubDate: 2017-11-10T11:39:44Z
      DOI: 10.1016/j.bjbas.2017.11.001
  • Coordination versatility of N2O4 polydentate hydrazonic ligand in Zn(II),
           Cu(II), Ni(II), Co(II), Mn(II) and Pd(II) complexes and antimicrobial

    • Authors: Fathy A. El-Saied; Mohamad M.E. Shakdofa; Abdou S. El Tabl; Mokhles M. Abd-Elzaher; Nagy Morsy
      Abstract: Publication date: Available online 6 November 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Fathy A. El-Saied, Mohamad M.E. Shakdofa, Abdou S. El Tabl, Mokhles M. Abd-Elzaher, Nagy Morsy
      New polydentate hydrazone ligand, was synthesized by the condensation of 1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carbaldehyde with adipodihydrazide. The structure of the synthesized ligand, N′1,N′6-bis((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl) methylene) adipohydrazide was elucidated by various analytical and spectroscopic techniques. The reactions of the ligand with zinc(II), copper(II), nickel(II), cobalt(II), manganese(II) and palladium(II) salts afforded homobinuclear metal complexes. Characterization and structure elucidation of the prepared complexes were achieved using different analytical and spectroscopic techniques. The analyses data indicated that this ligand behaved as N2O4 dibasic hexadentate ligand bonded covalency to the metal ions through the enolic carbonyl oxygen of hydrazide moiety and coordinated via carbonyl oxygen of antipyrine moiety and azomethine nitrogen atoms forming distorted octahedral geometry around the metal ions. The ESR spectra of copper(II) complexes (3) and (4) showed an axial symmetry with g >g⊥>ge, indicating distorted octahedral structure and presence of the unpaired electron in d(x2−y2) orbital. The microbicide studies of the ligand and its metal complexes (2), (3), (4), (5), (8), (11) and (13) showed that, all these complexes exhibit moderate to mild inhibitory effects on B. subtilis, E. coli while complexes (2), (3), (4) and (13) exhibit moderate to mild inhibitory effects on A. niger.

      PubDate: 2017-11-10T11:39:44Z
      DOI: 10.1016/j.bjbas.2017.09.005
  • Antimicrobial and cytotoxic comparative study of different extracts of
           Omani and SudaneseGum acacia

    • Authors: Said Musallam Al Alawi; Mohammad Amzad Hossain; Ahmed A. Abusham
      Abstract: Publication date: Available online 23 October 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Said Musallam Al Alawi, Mohammad Amzad Hossain, Ahmed A. Abusham
      Gum acacia, known as Gum Arabic in Oman is widely grown all over the tropical countries including Gulf region. The antimicrobial and cytotoxic activities of different polarity organic extracts of Omani and Sudanese Gum acacia latex has been investigated in this study using maceration method. Both Omani and Sudanese Gum acacia latex samples were used to prepare different fractions using various organic solvents. The antimicrobial activity of different organic extracts was determined through disc diffusion method against clinically isolated bacterial strains. The isolated pathogenic bacterial strain are Gram (+) Staphylococcus aureus (S. aureus, Code no. 659), Gram (-) Escherichia coli (E. coli, Code no. 846), Gram (-) Escherichia coli (E. coli, Code no. 683) and Gram (-) Klebsiella pneumoniae (Code no. 684). The antibiotic levofloxacin and dimethyl sulphoxide (DMSO) were used as positive and negative controls. The cytotoxic activity of the above mentioned organic extracts was determined by brine shrimp lethality method (BSL). Both latex samples of various polarity organic extracts at different concentrations showed antimicrobial activity against the isolated human bacterial strains with an inhibition range of 0-15 mm. However, both latex samples did not reveal a significant cytotoxic activity at any concentration. In conclusion, the organic extracts from both types of Gum acacia (Omani and Sudanese) represent a good source of natural antibiotic for the treatment of various infectious diseases.

      PubDate: 2017-10-26T09:42:46Z
      DOI: 10.1016/j.bjbas.2017.10.007
  • Apoptotic efficiency of aqueous extracts of turmeric, garlic and their
           active compounds in combination with Tamoxifen in lung and oral cancers: A
           comparative study.

    • Authors: Satish Kumar Vemuri; Rajkiran Reddy Banala; GPV. Subbaiah; Gurava Reddy AV; T Malarvili
      Abstract: Publication date: Available online 23 October 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Satish Kumar Vemuri, Rajkiran Reddy Banala, GPV. Subbaiah, Gurava Reddy AV, T Malarvili

      PubDate: 2017-10-26T09:42:46Z
      DOI: 10.1016/j.bjbas.2017.10.006
  • Effect of DPI's training-device on inhalation technique and clinical
           efficacy in asthmatics

    • Authors: Mina Nicola; Ahmed A. Elberry; Ossama M Sayed; Raghda R.S. Hussein; Mohamed E.A. Abdelrahim
      Abstract: Publication date: Available online 20 October 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Mina Nicola, Ahmed A. Elberry, Ossama M Sayed, Raghda R.S. Hussein, Mohamed E.A. Abdelrahim
      The aim of this work was to study the effect of using training device (In-Check DIAL) along with traditional dry powder inhaler (DPI) counseling on inhalation technique and pulmonary functions test (PFT) in asthmatics. Adult asthmatics >18years old were recruited in 3months study of investigation and training. They were divided into control and investigation groups. DPI inhalation technique was checked and mistakes were noted and corrected at every monthly visit. Their peak expiratory flow and forced expiratory volume in 1second as percentage of forced vital capacity were checked at each visit followed by showing patients the correct inhalation technique and how to use In-Check DIAL (investigation group). 29 patients (14 females) and 57 patients (30 females) in control and investigation groups respectively completed the study. Mean number of mistakes was significantly decreased (p<0.001) as the counseling session increased in both groups. Significant decrease in crucial mistake (inhalation quickly and forcefully until complete filling up of the lungs) that was very hard to be learned via only verbal counseling was noticed after the addition of In-Check DIAL. The improvement of the PFT results were significant from the second visit in the investigation group (p<0.05) and from the third visit in the control group (p<0.001). The decrease in the rate of rescue medication consumption was faster in investigation group than control group. Using training device along with verbal counseling has proven a beneficial role in inhalation technique resulting in optimum dosage delivery and yielding reasonable improvement in PFT.

      PubDate: 2017-10-26T09:42:46Z
      DOI: 10.1016/j.bjbas.2017.10.005
  • Antibacterial and anti-hyperlipidemic activities of the green alga
           Cladophora koeiei from Ad Dammam Seashore

    • Authors: Neveen Abdel-Raouf; Nouf Mohammad Al-Enazi; Ibraheem Borie Mohammad Ibraheem; Reem Mohammed Alharbi; Manal Mohammed Alkhulaifi
      Abstract: Publication date: Available online 12 October 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Neveen Abdel-Raouf, Nouf Mohammad Al-Enazi, Ibraheem Borie Mohammad Ibraheem, Reem Mohammed Alharbi, Manal Mohammed Alkhulaifi
      In the present investigation, an antihyperlipidemic activity of Cladophora koeiei ethanol extract against six pathogenic bacteria was conducted. Also, we evaluate the activity of the alga extract against hyperlipedemia in the administrated albino rates through measuring the blood lipid profiles [triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL-C), high-density lipoprotein cholesterol (HDL-C), cholesterol] and induced hepatic damage by measuring the contents of creatinine, total proteins, blood urea nitrogen (BUN), albumin and globulin and diagnostic marker enzymes such as aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT). Alga extract proved efficient activity against the tested bacteria ranged between medium and high suppression action. Results revealed also, the efficiency of C. koeiei extract in the decreasing the triglycerides (TG), total cholesterol (TC), low-density lipoproteins (LDL-C), blood urea nitrogen (BUN) and creatinine caused by alcohol. However, the treatment by alga extract exhibits high-density of lipoproteins (HDL-C) (beneficial), total protein, albumin, and globulins. Also, the algal treatments masking the lethal effects caused by harmful alcohol from raising the rate of enzymes ALT, AST, which returned to the normal state in the groups treated with alga extract. Our findings provide the evidence that new natural antioxidant substances can be present in the C. koeiei extract and hence this alga proves to be effective as a source for therapeutic agents.

      PubDate: 2017-10-19T06:19:45Z
      DOI: 10.1016/j.bjbas.2017.10.002
  • Rapid Biosynthesis of Silver Nanoparticles Using the marine red alga
           Laurencia catarinensis and their characterization

    • Authors: Neveen Abdel-Raouf; Reem Mohammed Alharbi; Nouf Mohammad Al-Enazi; Manal Mohammed Alkhulaifi; Ibraheem Borie Mohammad Ibraheem
      Abstract: Publication date: Available online 12 October 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Neveen Abdel-Raouf, Reem Mohammed Alharbi, Nouf Mohammad Al-Enazi, Manal Mohammed Alkhulaifi, Ibraheem Borie Mohammad Ibraheem
      Bio-synthesis of AgNPs (silver nanoparticles) by using of the dry and solvent extract of red marine alga Laurencia catarinensis was conducted in the present work. Characterizations of the formed AgNPs was approved by UV-Visible Spectroscopy, Transmission Electron Microscopy, Dynamic Light Scattering and finally by Fourier Transform Infrared spectroscopy. We achieved the synthesis of AgNPs by the reduction of aqueous solutions of AgNO3 with the powder and extract of Laurencia catarinensis. Bio-synthesis of Ag nanoparticles was confirmed by visual inspection. The obtained algal nanoparticles were characterized by highly stable formation, short time of the biogenic process (2min-3hr), small size (39.41–77.71 nm) with several shapes (spherical, triangular, rectangle, polyhedral and hexagonal).

      PubDate: 2017-10-19T06:19:45Z
      DOI: 10.1016/j.bjbas.2017.10.003
  • The heat transfer enhancement techniques and their Thermal Performance

    • Authors: Chirag Maradiya; Jeetendra Vadher; Ramesh Agarwal
      Abstract: Publication date: Available online 5 October 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Chirag Maradiya, Jeetendra Vadher, Ramesh Agarwal
      Heat transfer devices have been used for conversion and recovery of heat in many industrial and domestic applications. Over five decades, there has been concerted effort to develop design of heat exchanger that can result in reduction in energy requirement as well as material and other cost saving. Heat transfer enhancement techniques generally reduce the thermal resistance either by increasing the effective heat transfer surface area or by generating turbulence. Sometimes these changes are accompanied by an increase in the required pumping power which results in higher cost. The effectiveness of a heat transfer enhancement technique is evaluated by the Thermal Performance Factor which is a ratio of the change in the heat transfer rate to change in friction factor. Various types of inserts are used in many heat transfer enhancement devices. Geometrical parameters of the insert namely the width, length, twist ratio, twist direction, etc. affect the heat transfer. For example counter double twisted tape insert has TPF of more than 2 and combined twisted tape insert with wire coil can give a better performance in both laminar and turbulent flow compared to twisted tape and wire coil alone. In many cases, roughness gives better performance than the twisted tape as seen in case of flow with large Prandtl Number. The artificial roughness can be developed by employing a corrugated surface which improves the heat transfer characteristics by breaking and destabilizing the thermal boundary layer. This paper provides a comprehensive review of passive heat transfer devices and their relative merits for wide variety of industrial applications.

      PubDate: 2017-10-19T06:19:45Z
      DOI: 10.1016/j.bjbas.2017.10.001
  • Adulticidal and Repellent Activities of Some Botanical Oils against
           Malaria Mosquito: Anopheles gambiae (Diptera: Culicidae)

    • Authors: Afolabi O. Joseph; Simon-Oke I. Adepeju; Elufisan O. Oluwaloleyeayemi; Oniya M. Oladipo
      Abstract: Publication date: Available online 20 September 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Afolabi O. Joseph, Simon-Oke I. Adepeju, Elufisan O. Oluwaloleyeayemi, Oniya M. Oladipo
      The study is undertaken to determine the adulticidal efficacy and repellent activity of different solvent extracts of Ocimum caninum, Ocimum gratissimum, Chromolaena odorata and Datura stramonium against adult Anopheles gambiae. The extracts showed adulticidal activity at LC50 (0.82-4.58mg/l) and LC90 (2.38-8.33mg/l). The highest mortality was observed in Ocimum gratissimum and Datura stramonium with the LC50 and LC90 values of 2.35mg/l, 4.75ml/l and 0.82mg/l, 2.38mg/l respectively. Meanwhile, the lowest adulticidal activity was recorded in Chromolaena odorata with the lowest LC50 (4.52mg/l) and LC90 (8.32mg/l). The repellent efficacy was determined against the mosquitoes at five concentrations viz 1.0, 2.0, 3.0, 4.0 and 5.0 mg/l under laboratory condition (28±2°C, 75±5% RH, 12L: 12D photoperiod). The results showed complete protections of 90mins for Ocimum caninum, 120mins for Ocimum gratissimum, 30mins for Chromolaena odorata and 120mins for Datura stramonium at 5mg/l of the extracts respectively. It was observed that D. stramonium and O. gratissimum provided highest protection (120mins) against Anopheles gambiae while the least protection (30s) was observed in Chromolaena odorata at 5mg/l. The results of the study showed that all the crude extracts with the exception of Chromolaena odorata were potential botanicals for confirming protection on the exposed parts of human body against Anopheles gambiae for at least 90mins and as such can be included in integrated vector management to reduce malaria infection in endemic areas.

      PubDate: 2017-09-26T18:40:07Z
      DOI: 10.1016/j.bjbas.2017.09.004
  • Synergistic effect of ACE and AGT genes in Coronary Artery Disease

    • Authors: Ibrahim H. Borai; Nahla S. Hassan; Olfat G. Shaker; Esmat Ashour; Mohammed El Badrawy; Olfat M. Fawzi; Lamiaa Mageed
      Abstract: Publication date: Available online 18 September 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Ibrahim H. Borai, Nahla S. Hassan, Olfat G. Shaker, Esmat Ashour, Mohammed El Badrawy, Olfat M. Fawzi, Lamiaa Mageed
      Polymorphisms of the renin-angiotensin system genes influence the pathogenesis of atherosclerosis and are connected with heart diseases. We explore the potential associations of ACE (I/D) and AGT (M235T) gene polymorphisms with coronary artery disease (CAD). A total of one hundred and twenty Egyptian patients (Sixty with CAD and sixty without CAD) and fifty healthy control subjects were included in the study. Genotyping of ACE (I/D) and AGT (M235T) were analyzed by the polymerase chain reaction (PCR) technique. Serum lipid profiles (total cholesterol, triglyceride, HDL-C) were measured by the enzymatic colorimetric method. Our data showed that the ACE D allele frequency (P<0.0001; odds ratio [OR] =2.538, 95% confidence interval [CI] =1.468-4.388), DD genotype (P<0.0001, OR=0.239, 95% CI=0.066-0.866), the frequency of AGT T allele (P<0.0001, OR= 2.915, 95% CI= 1.666-5.097) and TT genotype (P<0001, OR=0.316, 95% CI=0.078-1.280) were significantly more prevalent among CAD patients and may be predisposing to CAD. We further found that the concomitant presence of the ACE-DD and AGT-TT genotypes increased the risk of CAD (P=0.017, OR=0.120, 95% CI=0.042-0.347).This study demonstrated the contribution of ACE (I/D) and AGT (M235T) gene polymorphisms individually or in combination to the presence of CAD risk in the Egyptian population. The ACE D allele and AGT T allele may be predictive in individuals at risk of developing CAD.

      PubDate: 2017-09-20T15:03:13Z
      DOI: 10.1016/j.bjbas.2017.09.003
  • Clinico-radiographic and histopathologic evaluation of iliac shaft
           fracture in dogs (An experimental study)

    • Authors: M.Z. Fathy; G.H. Ragab; M.M. Seif; S.M. Gadallah; Salah Deeb; Nesreen M. Safwat
      Abstract: Publication date: Available online 14 September 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): M.Z. Fathy, G.H. Ragab, M.M. Seif, S.M. Gadallah, Salah Deeb, Nesreen M. Safwat
      The pelvic region has a great importance as it is the connecting ring between the hind limbs and the trunk as well as having special shape. The present study was conducted on 15 adult, mongrel male dogs aged 2-3 years and weighted 15 – 20 kg. Iliac shaft fracture was induced experimentally, and the fractured ilium was fixed by Dynamic Compatable Plate (DCP). Fracture healing was evaluated clinically, radiologically and histopahologically. The animals were partially-weight bearing on the limb of operated side 4th day post-operatively and they were full-weight bearing within 17th days post-operatively. The gait was varied from occasional lameness to full function at the 21-28th post-operatively. The results of this study was conducted along 16 weeks confirmed that the internal fixation for fractured ilium using a bone plate and screws had a good fixation and healing and all animals returned to normal gait within short time.

      PubDate: 2017-09-15T14:59:21Z
      DOI: 10.1016/j.bjbas.2017.09.001
  • Antitumor activity of synthesized and characterized Cu(II), Ni(II) and
           Co(II) complexes of hydrazone-oxime ligands derived from 3-(hydroxyimino)

    • Authors: Fathy A. El-Saied; Tarek A. Salem; Mohamad M.E. Shakdofa; Ahmed N. Al-Hakimi; Ahmed S. Radwan
      Abstract: Publication date: Available online 9 September 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Fathy A. El-Saied, Tarek A. Salem, Mohamad M.E. Shakdofa, Ahmed N. Al-Hakimi, Ahmed S. Radwan
      Mononuclear and binuclear metal complexes of hydrazone oxime resulted from the condensation of acetohydrazide and pyridyl hydrazide with 3-(hydroxyimino) butan-2-one were prepared. All compounds were characterized using elemental, spectral and thermal analyses, as well as magnetic moment and molar conductance measurements. The ligands acted as neutral/monobasic bidentate, monobasic tridentate and dibasic tetradentate ligands bonded to the metal ions via azomethine nitrogen or oxime oxygen atoms and enolic carbonyl oxygen or pyridine nitrogen atom. The spectral and magnetic studies of the complexes showed that exhibit either distorted octahedral, square planer or tetrahedral geometry. Newly complexes were tested for their anti-proliferative activity in vitro against three human cell lines; MCF-7, Hep-G2 and HL-60. The cytotoxic action of the complexes was determined and compared to that of the anticancer drug doxorubicin. Results of cytotoxicity activities indicated that the compound (6) has a wide range of cytotoxicity against the three cell lines in concentration ranges as that of doxorubicin. It shows more cytotoxic against MCF-7 (IC50= 1.8 μM) and HL-60 (IC50= 10.6 μM) cancer cell lines. Compounds (H2L1) and (11) exhibited higher cytotoxic activities rather than doxorubicin against MCF-7 and HL-60 cell line. Compounds (2) and (11) are 3.1 and 2.1 times more active than doxorubicin; respectively, against HL-60 cell line.

      PubDate: 2017-09-15T14:59:21Z
      DOI: 10.1016/j.bjbas.2017.09.002
  • Interactive Approach for Multi-level Multi-objective Fractional
           Programming Problems with Fuzzy parameters

    • Authors: M.S. Osman; O.E. Emam; M.A. Elsayed
      Abstract: Publication date: Available online 9 September 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): M.S. Osman, O.E. Emam, M.A. Elsayed
      In this paper, an interactive approach for solving multi-level multi-objective fractional programming (ML-MOFP) problems with fuzzy parameters is presented. The proposed interactive approach makes an extended work of Shi and Xia (1997). In the first phase, the numerical crisp model of the ML-MOFP problem has been developed at a confidence level without changing the fuzzy gist of the problem. Then, the linear model for the ML-MOFP problem is formulated. In the second phase, the interactive approach simplifies the linear multi-level multi-objective model by converting it into separate multi-objective programming problems. Also, each separate multi-objective programming problem of the linear model is solved by the ∊-constraint method and the concept of satisfactoriness. Finally, illustrative examples and comparisons with the previous approaches are utilized to evince the feasibility of the proposed approach.

      PubDate: 2017-09-15T14:59:21Z
      DOI: 10.1016/j.bjbas.2017.08.005
  • Design Of Twisted Tape Turbulator At Different Entrance Angle For Heat
           Transfer Enhancement In A Solar Heater

    • Authors: Suvanjan Bhattacharyya; Himadri Chattopadhyay; Ayan Haldar
      Abstract: Publication date: Available online 31 August 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Suvanjan Bhattacharyya, Himadri Chattopadhyay, Ayan Haldar
      Numerical investigation of heat transfer characteristics in a tube fitted with inserted twisted tape swirl generator is performed. The twisted tapes are separately inserted from the tube wall. The configuration parameters include the, entrance angle (α) and pitch (H). Investigations have been done in the range of α = 180o, 160o and 140o with Reynolds number varying between 100 to 20,000. In this paper, transition - SST model which can predict the transition of flow regime from laminar through intermittent to turbulent has been utilized for numerical simulations. The computational results are in good agreement with experimental data. The results show that higher entrance angle yields a higher heat transfer value. The using of single twist twisted tape supplies considerable increase on heat transfer and pressure drop when compared with the conventional twisted tapes. A large data set has been generated for heat transfer and thermal-hydraulic performance which is useful for the design of solar thermal heaters and heat exchangers.

      PubDate: 2017-09-02T14:50:12Z
      DOI: 10.1016/j.bjbas.2017.08.003
  • In silico binding affinity studies of N-9 substituted
           6-(4-(4-propoxyphenyl)piperazin-1-yl)-9H-purine derivatives-Target for
           P70-S6K1 & PI3K- δ kinases

    • Authors: Manjunath G. Sunagar; P. Aravind; Supreet Gaonkar; K.S. Devaraju; Shrinivas D. Joshi; Sheshagiri R. Dixit; B.M. Harish; Imtiyaz Ahmed M. Khazi
      Abstract: Publication date: Available online 31 August 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Manjunath G. Sunagar, P. Aravind, Supreet Gaonkar, K.S. Devaraju, Shrinivas D. Joshi, Sheshagiri R. Dixit, B.M. Harish, Imtiyaz Ahmed M. Khazi
      P70-S6K1 & PI3K- δ kinases are identified to be involved in many physiological processes associated with cancer, therefore many of the inhibitors being designed to target these kinases are in clinical trials. In the current study we have exploited the N-9 substituted 6-(4-(4-propoxyphenyl) piperazin-1-yl)-9H-purine derivatives for their inhibitory properties with the above kinases. We have used an in silico docking study with seventeen purine derivatives for their binding affinity calculations. The binding affinities of these small molecules with P70-S6K1 & PI3K-δ were performed using AutoDock Vina. Among all the compounds, PP16 showed highest binding affinity of -14.7 kcal/mol with P70-S6K1 kinase & -17.2 kcal/mol with PI3K-δ kinases as compared to the molecules under clinical trials (PF-4708671 & IC-87114). Docking studies revealed that N-9 coumarine substituted purine derivative could be one of the potential ligands for the inhibition of P70-S6K1 & PI3K-δ kinases. Hence, this compound can be further investigated by in vitro and in vivo experiments for further validation.
      Graphical abstract image

      PubDate: 2017-09-02T14:50:12Z
      DOI: 10.1016/j.bjbas.2017.08.004
  • Synthesis and antibacterial activity studies of 2,4-di substituted furan

    • Authors: Sireesha Malladi; R. Venkata Nadh; K. Suresh Babu; P. Suri Babu
      Abstract: Publication date: Available online 15 August 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Sireesha Malladi, R. Venkata Nadh, K. Suresh Babu, P. Suri Babu
      2,4 disubstitiuted furan derivatives (8A–8M) were prepared from furan-4-carboxylic acid ethyl ester (1). Antibacterial activity of new 2,4 di substituted furan derivatives was studied against Gram (+) and Gram (−) bacteria. 8F, 8E, 8D and 8J were found to be effective against Gram (−) bacteria whereas, 8A and 8L were effective against Gram (+) bacteria. Least MIC value was found as 100µg/ml against Escherichia coli (for 8D and 8F), and Proteus vulgaris (for 8E and 8F). Antibacterial activity is correlated with different substituents. Products exhibited better antibacterial activities especially towards Streptococcus pyogenes, Proteus vulgaris, and Escherichia coli.
      Graphical abstract image

      PubDate: 2017-09-02T14:50:12Z
      DOI: 10.1016/j.bjbas.2017.08.001
  • Role of marine macroalgae in plant protection & improvement for
           sustainable agriculture technology

    • Authors: Seham M. Hamed; Amal A. Abd El-Rhman; Neveen Abdel-Raouf; Ibraheem B.M. Ibraheem
      Abstract: Publication date: Available online 14 August 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Seham M. Hamed, Amal A. Abd El-Rhman, Neveen Abdel-Raouf, Ibraheem B.M. Ibraheem
      Marine macroalgae are plant-like organisms with simple internal structures that generally live in coastal areas. They mainly includedifferent communities of red, brown and green macroalgae. Marine macroalgae commonly occupy intertidal and sublittoral-to-littoral zones on rocks and other hard substrata. They are considered to be an excellent natural biosource in different aspects of agricultural fields. They have great proficiency in improving soil physical and chemical properties. Marine macroalgae are also characterized by producing a large array of biologically active biocidal substances against plant-infecting pathogens. Unfortunately, most available literatures on marine macroalgae and their derivatives mainly focused on their pharmaceutical applications but their potential utilization in sustainable agriculture development is still often regarded asa secondary goal. However, a relatively considerable dataset on marine macroalgae showed that they could play a major role in plant protection and improvement. This review summarizes different aspects of potential macroalgal applications in agriculture. Commercial production and exploitation of specific compounds with interesting biotechnological importance from marine macroalgae including microbicides, nematicides, insecticides, biofertilizers, biostimulators and soil conditioners are highlighted and discussed in detail. Bioactive compounds like fatty acids (in particular polyunsaturated fatty acids (PUFAs), proteins (amino acids), bioflavonoids, sulfated polysaccharides, carotenoids, polyphenols and carbohydrates are considered to have bactericidal, antiviral and fungicidal effects against some plant-infecting pathogens. These biocontrol agents provide multiple benefits and act as useful pointers for improving cultivation practices in diverse habitats. Marine macroalgae can be generally considered as promising multifunctional bioinoculants and ecofriendly environmental tools in recent trends of organic farming.

      PubDate: 2017-09-02T14:50:12Z
      DOI: 10.1016/j.bjbas.2017.08.002
  • Detection of Methicillin Resistant and Toxin-Associated Genes in
           Staphylococcus aureus

    • Authors: Cajethan Ezeamagu; Irene Imanatue; Margaret Dosunmu; Adebola Odeseye; Glory Baysah; Daniel Aina; Foluke Odutayo; Grace Mensah-Agyei
      Abstract: Publication date: Available online 1 August 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Cajethan Ezeamagu, Irene Imanatue, Margaret Dosunmu, Adebola Odeseye, Glory Baysah, Daniel Aina, Foluke Odutayo, Grace Mensah-Agyei
      Methicillin-resistant Staphylococcus aureus is a problem in both healthcare institutions and community settings. This is due to its multi-drug resistant challenges. Hence, this study assessed the prevalence of methicillin resistant gene (mecA), exfoliative toxin (eta and etb) and toxic shock syndrome (tsst-1) genes in S. aureus isolated from clinical samples. A total of 120 clinical samples of patients (urine, high vagina swab (HVS), semen, wound swab, sputum and urethral swab) from a hospital laboratory were obtained. S. aureus was isolated and then identified with API-staph kit. Antibiotic susceptibility of the isolates was determined by agar diffusion while PCR was used to detect the presence of mecA and toxin-associated genes. Fifty S. aureus isolates were obtained at frequencies of 26(52%), 12(24%), 4(8%), 3(6%), 3(6%) and 2(4%) from the HVS, urine, semen, wound, sputum and urethral swab samples respectively. All the isolates of S. aureus were resistant to the antibiotics used in this study. MecA, tsst-1, eta and etb were detected in 19(38%), 7(14%), 3(6%) and 2(4%) of the isolates respectively. The prevalence of MRSA and its resistance pattern observed in this study was a signal that the health-care workers and the general public are at risk.

      PubDate: 2017-08-03T13:24:21Z
      DOI: 10.1016/j.bjbas.2017.07.010
  • The genus Vitex: An Overview of Iridoids as Chemotaxonomic Marker

    • Authors: M Bello Oluwasesan; Ahmed A. Zaki; Aloko Sinmisola; Pius S. Fasinu; M Bello Oluwatoyin; Usman L. Ajao; Oguntoye S. Olubunmi
      Abstract: Publication date: Available online 23 July 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): M Bello Oluwasesan, Ahmed A. Zaki, Aloko Sinmisola, Pius S. Fasinu, M Bello Oluwatoyin, Usman L. Ajao, Oguntoye S. Olubunmi
      In our continuing work on Vitex genus, the phytochemical investigation of leaves of Vitex grandifolia led to the isolation of two iridoids known in the literature as agnuside and bartsioside. The chemical structures were characterized by combined spectroscopic analysis. These compounds were isolated from this specie for the first time, this study give evidence to iridoids as chemotaxonomic marker and their constitutive presence has been reported in a number of genera in the family Lamiaceae. Iridoids have been isolated from nineteen species belonging to genus Vitex from Lamiaceae especially aucubin and agnuside. In addition to the utilization of morphological features of plants belonging to this genus, these compounds may be useful chemotaxonomic markers to aid taxonomic identification. This work evaluates and describes the distribution of iridoids in Vitex species to further establish this claim with structures of the iridoids found in this genus.

      PubDate: 2017-07-24T02:10:59Z
      DOI: 10.1016/j.bjbas.2017.07.004
  • A practical and powerful approach to potential KdV and Benjamin equations

    • Authors: Turgut Ak; Sharanjeet Dhawan
      Abstract: Publication date: Available online 22 July 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Turgut Ak, Sharanjeet Dhawan
      By making use of reduced differential transform method (RDTM), we analyse two model problems: the potential KdV equation which is believed to replicate tsunami waves and the Benjamin equation which is used in the analysis of long waves in shallow water. Our principal focus is to investigated computationally the travelling wave solutions of both the equations using RDTM. These solutions are going to be extremely useful for explaining various other nonlinear phenomena arising in various dynamical systems.

      PubDate: 2017-07-24T02:10:59Z
      DOI: 10.1016/j.bjbas.2017.07.008
  • Vernonia amygdalina: a folkloric herb with anthelminthic properties

    • Authors: Ifeoluwa T. Oyeyemi; Akinbiyi A. Akinlabi; Aderiike Adewumi; Abimbola O. Aleshinloye; Oyetunde T. Oyeyemi
      Abstract: Publication date: Available online 21 July 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Ifeoluwa T. Oyeyemi, Akinbiyi A. Akinlabi, Aderiike Adewumi, Abimbola O. Aleshinloye, Oyetunde T. Oyeyemi
      Vernonia amygdalina is a widely grown shrub plant in Africa consumed as vegetable and has high medicinal value. It has gained wide application in the treatment and management of various diseases. The leaves are useful components for herbal medicine constitution. The plant’s activities is a result of diverse bioactive compounds isolated from the different parts of the plant. These metabolites have specifically been efficacious against parasites especially worms. The mechanisms of activities include paralysis of worm, interference with energy generation and impairment with nutrient absorption, motility, and reproduction. The lack of considerable toxicity associated with the plant makes it a choice for further drug discovery. Effort should be made towards standardizing the extract(s) of V. amygdalina for use in alternative medicine for treatment of helminth-related diseases.

      PubDate: 2017-07-24T02:10:59Z
      DOI: 10.1016/j.bjbas.2017.07.007
  • Prevalence of Porcine Reproductive and Respiratory Syndrome Virus and
           Porcine Parvovirus Antibodies in Commercial Pigs, Southwest Nigeria

    • Authors: Comfort O. Aiki-Raji; Adebowale I. Adebiyi; John O. Abiola; Daniel O. Oluwayelu
      Abstract: Publication date: Available online 21 July 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Comfort O. Aiki-Raji, Adebowale I. Adebiyi, John O. Abiola, Daniel O. Oluwayelu
      Porcine reproductive and respiratory syndrome virus (PRRSV) and porcine parvovirus (PPV) infections cause significant economic losses to the pig industry and are considered the most economically important viral diseases of intensive swine production. Despite numerous reports on both diseases in several countries worldwide, the status of PRRSV and PPV in Nigeria remains largely unknown. Thus, a serological survey was conducted to determine the prevalence of PRRSV and PPV infections in pigs in Southwest Nigeria. Using commercial ELISA kits, 368 pig sera were screened for antibodies against PRRSV (types I and II) and PPV.Significantly higher antibody prevalence was obtained for PRRSV (53.8%) compared to PPV (36.1%). Since there is no vaccination against both diseases in the country, the findings of this study suggest that PRRSV and PPV are present in the pig population in southwest Nigeria. There should be continuous monitoring of pigs for these diseases in Nigeria since both viruses are associated with major economic losses in the swine industry, affecting all stages of production. This will help to ascertain the actual burden and increase awareness of both diseases to facilitate early detection in order to institute appropriate control measures in the country.

      PubDate: 2017-07-24T02:10:59Z
      DOI: 10.1016/j.bjbas.2017.07.006
  • A review on Quinoline hydrazone derivatives as a new class of potent
           antitubercular and anticancer agents

    • Authors: Mustapha C. Mandewale; Udaysinha C. Patil; Supriya V. Shedge; Uttam R. Dappadwad; Ramesh S. Yamgar
      Abstract: Publication date: Available online 20 July 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Mustapha C. Mandewale, Udaysinha C. Patil, Supriya V. Shedge, Uttam R. Dappadwad, Ramesh S. Yamgar
      Tuberculosis (TB) and Cancer remains a global public health problem in recent years. There is an urgent need for the screening of new bioactive molecules with new targets and with a different mechanism of action. Among heterocyclic compounds, compounds with Quinoline core gained much importance in medicinal chemistry. Quinoline hydrazone scaffold plays an important role in anti-tuberculosis and anticancer drug development as their derivatives have shown outstanding results. This broad spectrum of biological and biochemical activities has been further assisted by the synthetic flexibility of quinoline, which permits the invention of a large number of structurally varied hydrazone derivatives and their metal complexes. In order to pave the way for future advanced research, there is a need to collect and analyze the latest information available so far in this promising area. In this review, we have compiled and discussed the published reports specifically on anti-tuberculosis and anticancer potential of quinoline hydrazone derivatives. It is hoped that this review will be helpful for researchers in developing a new view in the search for rational designs of more active and less toxic quinoline-based anti-TB and anticancer drugs.
      Graphical abstract image

      PubDate: 2017-07-24T02:10:59Z
      DOI: 10.1016/j.bjbas.2017.07.005
  • Evaluation of the epidural analgesic effect of Nalbuphine, Lidocaine and
           Nalbuphine – Lidocaine combination in bucks

    • Authors: G.A. Ragab; M.Z. Fathy
      Abstract: Publication date: Available online 14 July 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): G.A. Ragab, M.Z. Fathy
      Nalbuphine is a lipophilic opioid which could be used subcutaneously, intramuscularly, intravenously and epidurally in human, dogs and equine but not used in bucks until yet. The aim of the existing study was to compare the analgesic effect of Nalbuphine, Lidocaine and Nalbuphine – Lidocaine combination injected epidurally in bucks. Fifteen adult apparently healthy bucks were used. The animals were randomly divided into three groups (five animals in each one); group (1) was injected with Nalbuphine HCl at a dose 3mg/kg, group (2) was injected with Lidocaine HCl 2% at a dose 2.5mg / kg. Finally, group (3) was injected with Nalbuphine-Lidocaine combination at a dose (1.5mg /kg and 1.25mgkg, resp.) to evaluate the analgesic effect of each treatment. Onset and duration of analgesia were recorded after each treatment. Respiratory rate, heart rate, rectal temperature and biochemical parameters were recorded for each treatment. The results revealed that, the onset and duration of analgesia respectively were 12±2min and 200±4min in group (1), 6±1min and 80±3min in group (2) and 8±2min and 120±5min in group (3). In Nalbuphine group, No ataxia was observed while mild ataxia was observed in Nalbuphine-Lidocaine combination group but in Lidocaine treated group, sever ataxia was recorded. Heart rate increased at 90–120 and respiratory rate rectal temperature had no any significantly differentiation from baseline of any treatment. Biochemical parameters returned to basal levels through three hours after all treatments. In conclusion, Nalbuphine – lidocaine combination is useful to perform surgical operations of long duration and had effective analgesia in bucks.

      PubDate: 2017-07-24T02:10:59Z
      DOI: 10.1016/j.bjbas.2017.07.001
  • Effect of cypermethrin on the ovarian activity and its impact on fertility
           and pubertal onset of offspring

    • Authors: Nada M.H. Al-Hamdani; H.N. Yajurvedi
      Abstract: Publication date: Available online 10 July 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Nada M.H. Al-Hamdani, H.N. Yajurvedi
      Oral (by gavage) administration of cypermethrin (CYP), (3 doses; 1.38, 2.76 and 5.52 mg/kg body weight) to female mice for two durations (6 weeks and 12 weeks), caused significant reduction in the number of estrous cycles per month, serum levels of estradiol, total number of healthy ovarian follicles and number of corpora lutea whereas there was an increase in number of atretic follicles of all categories compared to controls. Mice of all treated groups after 6 weeks treatment showed 100% fertility. It was 80% in low and medium doses and 60% in high dose treatment after 12 weeks. There was a significant delay in the onset of puberty and reduction in number of estrous cycles of progeny of medium and high dose CYP treated mice mated with normal males. Number of estrous cycles per month, healthy follicles, corpora lutea and serum levels of estradiol, were not reversible within 6 weeks after cessation of medium and high dose treatment for 12 weeks. The study first time reveals that reversibility of the reproductive toxic effects of CYP depends on quantum and duration of exposure.

      PubDate: 2017-07-12T01:22:09Z
      DOI: 10.1016/j.bjbas.2017.07.003
  • A fuzzy logic based promethee method for material selection problems

    • Authors: Muhammet Gul; Erkan Celik; Alev Taskin Gumus; Ali Fuat Guneri
      Abstract: Publication date: Available online 8 July 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Muhammet Gul, Erkan Celik, Alev Taskin Gumus, Ali Fuat Guneri
      Material selection is a complex problem in the design and development of products for diverse engineering applications. This paper presents a fuzzy PROMETHEE (Preference Ranking Organization Method for Enrichment Evaluation) method based on trapezoidal fuzzy interval numbers that can be applied to the selection of materials for an automotive instrument panel. Also, it presents uniqueness in making a significant contribution to the literature in terms of the application of fuzzy decision-making approach to material selection problems. The method is illustrated, validated, and compared against three different fuzzy MCDM methods (fuzzy VIKOR, fuzzy TOPSIS, and fuzzy ELECTRE) in terms of its ranking performance. Also, the relationships between the compared methods and the proposed scenarios for fuzzy PROMETHEE are evaluated via the Spearman’s correlation coefficient. Styrene Maleic Anhydride and Polypropylene are determined optionally as suitable materials for the automotive instrument panel case. We propose a generic fuzzy MCDM methodology that can be practically implemented to material selection problem. The main advantages of the methodology are consideration of the vagueness, uncertainty, and fuzziness to decision making environment.

      PubDate: 2017-07-12T01:22:09Z
      DOI: 10.1016/j.bjbas.2017.07.002
  • Preparation of environmental friendly phenol-formaldehyde wood adhesive
           modified with kenaf lignin

    • Authors: M. Hazwan Hussin; Hau Han Zhang; Nurul Azila Aziz; Noraini Abd Samad; Abbas Hassan Faris; Mohamad Nasir Mohamad Ibrahim; Anwar Iqbal; Ahmad Faiz Abdul Latip; M.K. Mohamad Haafiz
      Abstract: Publication date: Available online 27 June 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): M. Hazwan Hussin, Hau Han Zhang, Nurul Azila Aziz, Noraini Abd Samad, Abbas Hassan Faris, Mohamad Nasir Mohamad Ibrahim, Anwar Iqbal, Ahmad Faiz Abdul Latip, M.K. Mohamad Haafiz

      PubDate: 2017-07-03T01:16:25Z
      DOI: 10.1016/j.bjbas.2017.06.004
  • Optimization of paclitaxel loaded poly (ε-caprolactone) nanoparticles
           using box behnken design

    • Authors: Nandhakumar Sathyamoorthy; Dhanaraju Magharla; Pavankumar Chintamaneni; Sundar Vankayalu
      Abstract: Publication date: Available online 16 June 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Nandhakumar Sathyamoorthy, Dhanaraju Magharla, Pavankumar Chintamaneni, Sundar Vankayalu
      Optimization is a critical process in the development of nanoparticles to apprehend the formulation variables and quality attributes. The purpose of this study was to evaluate the influence of formulation variables viz., drug/polymer ratio (A), surfactant concentration (B) and ratio of volume of internal to external phase (C) on the dependent variables (particle size, % EE and zeta potential) of paclitaxel loaded poly (ε-caprolactone) nanoparticles using Box-Behnken design. The nanoparticles were fabricated using emulsion-solvent evaporation technique. The generated polynomial equations, contour plots and response surface plots of the design space were used to analyze the relationship between independent variables and the observed response. An optimal batch was formulated with selected variables (A: +1 level, B: 0 level, C: -1 level) and the prepared nanoparticles were found to have particle size 215.6 µm, zeta potential -7.52 mV and % drug entrapment 86.78%. The observed responses are in close agreement with the predicted values. NPs were spherical with a smooth surface as revealed by morphological studies and the drug-polymer compatibility was established using FTIR and thermal analysis. The drug was released from the NPs in a biphasic pattern with an initial burst release (32.1 %) followed by sustained release (53 %) at the end of 5 d. The in vitro cell cytotoxicity studies on MCF-7 cells showed that the NPs held superior tumour inhibition ability. The results encourage the application of Box-Behnken design for the optimization of critical variables and fabrication of nanoparticles with desirable properties for drug delivery.

      PubDate: 2017-06-16T22:09:06Z
      DOI: 10.1016/j.bjbas.2017.06.002
  • Spectral thermal cytotoxic and molecular docking studies of
           N'-2-hydroxybenzoyl; pyridine-4-carbohydrazide its complexes

    • Authors: R. Mohammed Shafeeulla; G. Krishnamurthy; H.S. Bhojynaik; H.P. Shivarudrappa; Yallappa Shiralgi
      Abstract: Publication date: Available online 13 June 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): R. Mohammed Shafeeulla, G. Krishnamurthy, H.S. Bhojynaik, H.P. Shivarudrappa, Yallappa Shiralgi

      PubDate: 2017-06-16T22:09:06Z
      DOI: 10.1016/j.bjbas.2017.06.001
  • Molecular Docking Analysis and Antidiabetic activity of Rifabutin against
           STZ-NA induced diabetes in albino wistar rats

    • Authors: Danish Ahmed; Mohd. Ibrahim Khan; Gaurav Kaithwas; Subhadeep Roy; Swetlana Gautam; Manjari Singh; Uma Devi; Rajnsih Yadav; Jitendra Rawat; Shubhini Saraf
      Abstract: Publication date: Available online 25 April 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Danish Ahmed, Mohd. Ibrahim Khan, Gaurav Kaithwas, Subhadeep Roy, Swetlana Gautam, Manjari Singh, Uma Devi, Rajnsih Yadav, Jitendra Rawat, Shubhini Saraf
      Computer Aided Drug Design (CADD) molecular docking program used in this study and as a result Rifabutin was retrieved as structurally similar drug molecule to Lixisenatide (A widely used GLP-1 agonist). To afford beneficial reason in-vitro study conducted which too provides a favourable mark for prospective inhibition of α-glucosidase and α-amylase enzyme and thereby evaluated for its antidiabetic potential against Streptozotocin (STZ) and Nicotinamide (NA) induced diabetes in albino wistar rats. Rifabutin demonstrated significant efficacy towards restoring the blood glucose, insulin and distorted lipid profile in the animals treated with STZ-NA. Rifabutin also regulated the inflammatory (Nitric Oxide) and oxidative stress (TBARs, SOD, Catalase, GSH and protein carbonyl) markers in the pancreatic tissue of the STZ-NA treated animals. When scrutinized on the grounds electrocardiographic and heart rate variability (HRV) changes, Rifabutin decreased the heart rate, without much affecting the QRS, QT and QTc interval. Rifabutin was also evident to be less hepatotoxic in comparison to the standard metformin, providing an added advantage as an anti-diabetic agent. The study concluded that the low dose of rifabutin can favourably regulate of the blood glucose and other biochemical paradigms in comparison to high dose of rifabutin.
      Graphical abstract image

      PubDate: 2017-04-26T15:19:11Z
      DOI: 10.1016/j.bjbas.2017.04.010
  • Heavy metal and Potential Ecological Risk Assessment in sedimentscollected
           from Poombuhar to Karaikal Coast of Tamilnadu using Energy dispersive
           X-ray fluorescence (EDXRF) technique

    • Authors: E. Devanesan; M. Suresh Gandhi; M. Selvapandian; G. Senthilkumar; R. Ravisankar
      Abstract: Publication date: Available online 24 April 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): E. Devanesan, M. Suresh Gandhi, M. Selvapandian, G. Senthilkumar, R. Ravisankar
      Heavy metal concentrations in coastal sediments from Poombuhar to Karaikal of South East Coast of Tamilnadu were conducted to evaluate the level of contamination. The metal concentrations were analyzed in sediment samples using Energy dispersive X-ray fluorescence technique. The determined mean metal concentration is in the order of Ca > Ti > K > Al > Fe > Mg > Zn > Ni > Cr > V > Mn > Co The heavy metals contamination in sediments is assessed using pollution indices like Contamination factor (Cf), Contamination Degree (Cd), Modified Degree of Contamination (mCd) and potential contamination index (Cp). The environmental risks of the heavy metals in sediments assessed by the potential ecological risk factor. From the analysis, sediments are polluted by Ti, V, Cr, Mn, Ca and Pb due to anthropogenic activites (fishermen boat activites) in the study area. The results of this study would provide a useful aid for sustainable marine management in the region.

      PubDate: 2017-04-26T15:19:11Z
      DOI: 10.1016/j.bjbas.2017.04.011
  • Impact of Generic Antimalarial or Phyllanthus Amarus and Vitamin
           Co-Administration on Antioxidant Status of Experimental Mice Infested With
           Plasmodium Berghei

    • Authors: Matthew Obaineh Ojezele; Emuesiri Goodies Moke; Innocent Onyesom
      Abstract: Publication date: Available online 24 April 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Matthew Obaineh Ojezele, Emuesiri Goodies Moke, Innocent Onyesom
      Oxidative stress is a key factor in malaria pathogenesis, particularly, malaria induced anaemia and pathological changes in some organs in the body. This research aimed at investigating the effect of Phyllanthus amarus seed extract (PASE), chloroquine (CLQ), and artesunate (ATS) used alone and co-administered with vitamin A, B, C, or E on oxidative stress in Plasmodium berghei-infected mice. A total of eighty (80) adult albino male mice infected with P. berghei (NK 65 strain) were randomly allotted to 16 treatment groups, mice in another group (17th group) were uninfected; n=5. Of the treatment groups, fifteen were administered sole generic antimalarials/PASE and combined vitamins A, B, C or E orally for 5 days. Biochemical assay for glutathione peroxidase (GPx), and glutathione reductase (GR) were carried out on the serum. Assay for glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD), catalase (CA), and malondialdehyde (MDA) levels were carried out on homogenised liver and brain. Treatment with PASE, CLQ and ATS combined with vitamin A, B, or E respectively, demonstrated significant increase in the serum levels of GPx and GR concentration. Treatment with PASE/ATS alone and in combination with vitamin A, B, C, and E significantly increased the liver GPX, SOD, and CA levels with significant decrease in liver MDA levels. Treatment with PASE/CLQ alone and in combination with vitamin A, B, C, and E significantly increased the brain GPX, GR and SOD levels with significant decrease in brain MDA levels. PASE showed enhanced antioxidant capacity in plasmodiasis solely or combined with vitamins A, B and E. Furthermore the co-administration of generic agent like artesunate with vitamins A, B, and E enhanced the antimalarial activity and treatment outcome as shown by the antioxidant effects. However, co-administration with vitamin C may be counter-productive.

      PubDate: 2017-04-26T15:19:11Z
      DOI: 10.1016/j.bjbas.2017.04.008
  • Backing of 2-(Diethylamino)-N-(2, 6-dimethylphenyl) – acetamide with
           Molecular, Electronic and Docking Studies

    • Authors: J. Deva Anban; Sayantan Pradhan; C. James
      Abstract: Publication date: Available online 24 April 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): J. Deva Anban, Sayantan Pradhan, C. James
      In this study, the anaesthetic compound 2-(diethylamino)-N-(2, 6-dimethylphenyl)-acetamide (DEAL) was optimized with the B3LYP- 6-311+ G (d, p) density functional theory method. Hyper conjugative interactions revealed the bioactivity of the molecule by natural bond orbital analysis. The current–potential curves were noted at well-defined scan rates by cyclic voltammetry. The solvation free energy was calculated by applying the solvation model on density. Molecular docking simulations were carried out to understand the pharmacokinetic behaviour of the drug. Besides, total energy levels of HOMO-LUMO orbitals, Mulliken atomic charges, natural population analysis and polarizability properties of the molecule were calculated. We found that the secondary amide increases the stability of this molecule. The π→π∗ interactions increase the biological activity of the compound, leading to a very high stabilization.

      PubDate: 2017-04-26T15:19:11Z
      DOI: 10.1016/j.bjbas.2017.04.012
  • Hepatotoxicity and Genotoxicity of Gasoline Fumes in Albino Rats

    • Authors: Folarin O. Owagboriaye; Gabriel A. Dedeke; Joseph S. Ashidi; A.A. Aladesida; Wasiu E. Olooto
      Abstract: Publication date: Available online 24 April 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Folarin O. Owagboriaye, Gabriel A. Dedeke, Joseph S. Ashidi, A.A. Aladesida, Wasiu E. Olooto
      Toxic effects of gasoline fumes have been reported, but evidence of its hepatotoxicity and genotoxicity are rare. Therefore, this study assesses hepatotoxicity and genotoxicity of gasoline fumes on forty Albino rats randomly assigned to five experimental treatments (T) with eight rats per treatment (T1, T2, T3, T4 and T5). T1(Control) was housed in a section of experimental animal house free from gasoline fumes while T2, T3, T4 and T5 were exposed to gasoline fumes in exposure chambers for one, three, five and nine hours daily respectively for twelve weeks. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and histopathological examination of the liver tissues were used as diagnostic markers to assess liver dysfunction. Genotoxicity test was conducted on the lung tissues using randomly amplified polymorphic DNA fingerprinting polymerase chain reaction (RAPD PCR) technique. Significant increase (p<0.05) in the level of ALT, AST and ALP for T2, T3, T4 and T5 compared to T1 were recorded. Photomicrograph examination of the liver sections of T1 showed hepatic tissue with normal liver cell architecture while that of T2, T3, T4 and T5 revealed degenerative changes in the ultrastructural integrity of the hepatic cells. Genotoxicity test revealed DNA bands at a reducing intensity from T1 to T5. Dendrogram showed DNA damage in the lungs of T3, T4 and T5 were closely similar and the genotoxic impact was more in T3. Frequent exposure to gasoline fumes was observed to induce hepatoxicity and genotoxicity, hence impairing the normal liver function and gene structure.

      PubDate: 2017-04-26T15:19:11Z
      DOI: 10.1016/j.bjbas.2017.04.007
  • Taurine Dietary Supplementation Attenuates Brain, Thyroid, Testicular
           Disturbances and Oxidative Stress in Streptozotocin-Induced Diabetes
           Mellitus in Male Rats

    • Authors: N.A. Mohamed; H.S. Abdel Gawad
      Abstract: Publication date: Available online 24 April 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): N.A. Mohamed, H.S. Abdel Gawad
      The metabolic dysregulation associated with DM causes secondary pathophysiological changes in multiple organ systems. This work aimed to study the effect of taurine supplementation on brain, thyroid, testicular disturbances and oxidative stress in diabetic rats. Male Wistar rats were randomly divided into four groups (Group 1, control; group 2, diabetic; group 3, diabetic+taurine; group 4, taurine). The results illustrated that the dietary taurine intake was effective in lowering the elevated plasma levels of AChE, GnRH, TSH, FSH and LH in diabetic rats compared to untreated ones (P<0.05), whereas TRH, T3, T4 and testosterone, were significantly increased. Taurine improved the sperm characteristics in diabetic rats as indicated by sperm counts and motility. The data revealed that taurine intake was able to reverse the oxidative effect of diabetes on the antioxidant status of brain, thyroid and testis in diabetic rats. The taurine treated group also showed a significant improvement in the degenerative changes of the seminiferous tubules and spermatogenesis. In summary, it was suggested that taurine may have a regulatory effect on diabetes-induced changes in the gonadal-hormone levels by inhibiting hypothalamic–pituitary–gonadal axis and thyroid dysfunctions in the diabetic male rats.

      PubDate: 2017-04-26T15:19:11Z
      DOI: 10.1016/j.bjbas.2017.04.006
  • Internal Transcribed Sequence (ITS) ofHalocafeteria seosinensis

    • Authors: Rathinam Raja; Shanmugam Hemaiswarya; Venkatesan ganesan; Isabel S Carvalho
      Abstract: Publication date: Available online 24 April 2017
      Source:Beni-Suef University Journal of Basic and Applied Sciences
      Author(s): Rathinam Raja, Shanmugam Hemaiswarya, Venkatesan ganesan, Isabel S Carvalho
      The aim of the current study was to characterize and identify the smaller subunit (18S) and Internal Transcribed Spacer (ITS) regions, ITS1 and ITS2 (ITS1-5.8S-ITS2) of Halocafeteria seosinensis (Bicosoecida). Halocafeteria was isolated from the salterns of Morocco and maintained using standard techniques. The ITS1 and ITS2 are non-conserved regions which were amplified using universal primers, ITS1 and ITS4. The purified PCR products were directly sequenced by Sanger dideoxy sequencing technology and submitted to GenBank. For the construction of cladogram, closely related 18S rDNA sequences obtained from GenBank were multiple aligned using MEGA 6 software and the cladogram constructed by maximum likelihood method with 10000 bootstrapping (BP) repetitions. The phylogenetic relationship among the other related stramenopiles were also studied. The molecular characterization by PCR of 18S genes was useful in confirming the taxonomic identity of a biflagellated H. seosinensis gen. et sp. nov. The ITS1-5.8S-ITS2 region of Halocafeteria is the one to be characterized for the very first time in the whole family of Bicosoecida. Due to discrepancy in placing Halocafeteria in Bicosoecida family, there is need in the characterization of ITS region sequences of stramenopiles and to use multigenes (such as 18S and ITS regions) for reconstructing the evolution tree.

      PubDate: 2017-04-26T15:19:11Z
      DOI: 10.1016/j.bjbas.2017.04.009
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