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Moroccan Journal of Heterocyclic Chemistry
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This is an Open Access Journal

Open Access journal
ISSN (Online) 1114-7792
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ASSEMBLY OF FULLERENE FINE CRYSTALS: FABRICATION OF 1D, 2D AND 3D
STRUCTURES FROM 0D FULLERENE
- Authors: Dorra Mahdaoui, Takatsugu Wakahara, Kun’ichi Miyazawac, Néji Besbes, Manef Abderrabba
  Pages: 20 - 4 (2021) 3
  Abstract: Fullerene molecules with closed cage structures, extended π systems, excellent mechanical
  and photochemical stability and unique semiconducting properties are ideal blocks toconstruct various supramolecular assemblies and functional materials. Furthermore, zero-
  dimensional fullerene molecules with only a single elemental component, carbon, without anycharged or interactive functional groups are excellent units for self assembly. Researches on
  fullerene micro and nanostructures, especially crystallization of fullerene molecules into
  ordered molecular assemblies have grown rapidly during recent years. In this short review, we
  introduce various examples of self assembled fullerenes and their derivatives. An outline and
  background of fullerene properties are first described (introduced), followed by several
  examples of fullerene assemblies, such as wiskers, tubes, sheets, cubes, hole in cubes and
  hopper shaped fullerenes. Also a demonstration of factors influencing morphologies of
  fullerene assemblies and future applications of obtained crystals is done.
  PubDate: 2022-01-10
  DOI: 10.48369/IMIST.PRSM/jmch-v20i4.30096
  Issue No: Vol. 20, No. 4 (2022)
SYNTHESIS OF NEW N-ALKYL-2-BENZYLTHIOPYRIMIDINE DERIVATIVES AND
CONCENTRATIONS INFLUENCE ON MULTIRESISTANT BACTERIA GROWTH
- Authors: Achi Patrick-Armand, Coulibali Siomenan, Zon Doumade, Timotou Adéyolé, Bolou Eric, Coulibaly Souleymane, Ballo Daouda, Sissouma Drissa, Adjou Ané
  Pages: 20 - 4 (2021) 1
  Abstract: Synthesis and study of new N-alkyl-2-benzylsulfanyl-pyrimidines concentration influences on multidrug resistant bacteria growth are presented in this article. This novel series are compounds 3a-k derived from 1-ethyl or 1-benzyl-2- benzylsulfanyl -6-methyl-4-phenyl-1,4- dihydropyrimidine-5-carboxylates. They were obtained by condensation reaction between 2- benzylsulfanyl-pyrimidines (1) and benzyl chloride or ethyl bromide (2) in the presence of potassium carbonate (K2CO3). The compounds synthesized were characterized by 1H, 13C Nuclear Magnetic Resonance (NMR) spectra and High-Resolution Mass Spectrometry (HRMS). Among these compounds, ten were evaluated for their potential antibacterial activity on multidrug-resistant strains of Escherichia coli and Staphylococcus aureus. The results showed a negative influence against the tested bacteria growth. Compounds 3b, 3d, 3f, 3h, 3e and 3k were more potent on S. aureus with IC50 ranging from 6.04 to 28.59 µg / mL The compounds 3b, 3c, 3f, 3g, 3h and 3j were more active on E. coli with IC50 between 7.21 and 26.59 µg / mL.
  PubDate: 2021-11-08
  DOI: 10.48369/IMIST.PRSM/jmch-v20i4.28999
  Issue No: Vol. 20, No. 4 (2021)
COPPER CATALYSED AZIDE-ALKYNE CYCLOADDITION INVOLVING 1,12-DIAZIDODODECANE
AND 1,5-BENZODIAZEPINE2,4-DIONE DERIVATIVES
- Authors: Youssef Kandri Rodi, Hind Jabli, Rachida Dardouri, Fouad Ouazzani Chahdi, Said Chakroune
  Pages: 20 - 4 (2021) 1
  Abstract: Copper catalysed azide-alkyne cycloaddition have been undertaken involving as azide 1,12diazido-dodecane and 1,5-dibenzyl-3-propargyl-1,5-benzodiazepine-2,4-dione 1 and 7-chloro-1,5-dipropargyl-1,5-benzodiazepine-2,4-dione 2 as dipolarophiles. The reactions studied led exclusively in each case to 3-(1-azidododecyl-1,2,3-triazol-4-ylmethyl)-1,5- benzodiazepine-2,4-dione 3 and a di-1,2,3-triazolyl macrocyclic ligand 4. The structures of compounds isolated 3 and 4 have been elucidated on the basis of 1H NMR, 13C NMR and comfirmed by a single crystal X-ray diffraction studies.
  PubDate: 2021-11-08
  DOI: 10.48369/IMIST.PRSM/jmch-v20i4.28991
  Issue No: Vol. 20, No. 4 (2021)
SYNTHESIS AND FUNCTIONALIZATION OF THE PYRAZOLO [3,4-b]PYRIDIN-3-ONES
RESEARCH OF THE SEROTONINERGIC ACTIVITY
- Authors: S. Fadel, F. Suzenet, M. Khouili, E. M. Rakib, G. Guillaumet
  Pages: 20 - 4 (2021) 2
  Abstract: A convenient route to the synthesis of pyrazolo[3,4-b]pyridin-3-ones via condensation of 3- amino-1-phenylpyrazolin-5-one with 4-hydroxy-6-methylpyran-2-one. The isomeric pyrazolo[3,4-b]pyridin-3-ones obtained are functionalized in position 4 or 6 by aliphatic and aromatic amines, on the other hand position 1 of another derivative pyrazolopyridinic was functionalized by a synthetic grouping. The serotoninergic activity of the various compounds obtained was also examined and discussed.
  PubDate: 2021-11-08
  DOI: 10.48369/IMIST.PRSM/jmch-v20i4.28992
  Issue No: Vol. 20, No. 4 (2021)

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