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  Subjects -> CHEMISTRY (Total: 849 journals)
    - ANALYTICAL CHEMISTRY (50 journals)
    - CHEMISTRY (598 journals)
    - CRYSTALLOGRAPHY (22 journals)
    - ELECTROCHEMISTRY (25 journals)
    - INORGANIC CHEMISTRY (42 journals)
    - ORGANIC CHEMISTRY (45 journals)
    - PHYSICAL CHEMISTRY (67 journals)

CHEMISTRY (598 journals)                  1 2 3 | Last

Showing 1 - 200 of 735 Journals sorted alphabetically
2D Materials     Hybrid Journal   (Followers: 8)
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 26)
ACS Catalysis     Full-text available via subscription   (Followers: 32)
ACS Chemical Neuroscience     Full-text available via subscription   (Followers: 17)
ACS Combinatorial Science     Full-text available via subscription   (Followers: 23)
ACS Macro Letters     Full-text available via subscription   (Followers: 23)
ACS Medicinal Chemistry Letters     Full-text available via subscription   (Followers: 39)
ACS Nano     Full-text available via subscription   (Followers: 226)
ACS Photonics     Full-text available via subscription   (Followers: 11)
ACS Synthetic Biology     Full-text available via subscription   (Followers: 21)
Acta Chemica Iasi     Open Access   (Followers: 2)
Acta Chimica Sinica     Full-text available via subscription   (Followers: 1)
Acta Chimica Slovaca     Open Access   (Followers: 1)
Acta Chromatographica     Full-text available via subscription   (Followers: 9)
Acta Facultatis Medicae Naissensis     Open Access  
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 5)
Acta Scientifica Naturalis     Open Access   (Followers: 2)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 5)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 7)
Adsorption Science & Technology     Full-text available via subscription   (Followers: 5)
Advanced Functional Materials     Hybrid Journal   (Followers: 50)
Advanced Science Focus     Free   (Followers: 3)
Advances in Chemical Engineering and Science     Open Access   (Followers: 53)
Advances in Chemical Science     Open Access   (Followers: 13)
Advances in Chemistry     Open Access   (Followers: 14)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Enzyme Research     Open Access   (Followers: 9)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 8)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 15)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8)
Advances in Materials Physics and Chemistry     Open Access   (Followers: 19)
Advances in Nanoparticles     Open Access   (Followers: 14)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15)
Advances in Polymer Science     Hybrid Journal   (Followers: 41)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 19)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Science and Technology     Full-text available via subscription   (Followers: 12)
African Journal of Bacteriology Research     Open Access  
African Journal of Chemical Education     Open Access   (Followers: 2)
African Journal of Pure and Applied Chemistry     Open Access   (Followers: 7)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 67)
American Journal of Biochemistry and Molecular Biology     Open Access   (Followers: 14)
American Journal of Chemistry     Open Access   (Followers: 26)
American Journal of Plant Physiology     Open Access   (Followers: 13)
American Mineralogist     Hybrid Journal   (Followers: 13)
Analyst     Full-text available via subscription   (Followers: 38)
Angewandte Chemie     Hybrid Journal   (Followers: 159)
Angewandte Chemie International Edition     Hybrid Journal   (Followers: 210)
Annales UMCS, Chemia     Open Access   (Followers: 1)
Annals of Clinical Chemistry and Laboratory Medicine     Open Access   (Followers: 1)
Annual Reports in Computational Chemistry     Full-text available via subscription   (Followers: 3)
Annual Reports Section A (Inorganic Chemistry)     Full-text available via subscription   (Followers: 3)
Annual Reports Section B (Organic Chemistry)     Full-text available via subscription   (Followers: 8)
Annual Review of Chemical and Biomolecular Engineering     Full-text available via subscription   (Followers: 12)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 14)
Anti-Infective Agents     Hybrid Journal   (Followers: 3)
Antiviral Chemistry and Chemotherapy     Hybrid Journal  
Applied Organometallic Chemistry     Hybrid Journal   (Followers: 7)
Applied Spectroscopy     Full-text available via subscription   (Followers: 23)
Applied Surface Science     Hybrid Journal   (Followers: 28)
Arabian Journal of Chemistry     Open Access   (Followers: 6)
ARKIVOC     Open Access   (Followers: 2)
Asian Journal of Biochemistry     Open Access   (Followers: 1)
Atomization and Sprays     Full-text available via subscription   (Followers: 3)
Australian Journal of Chemistry     Hybrid Journal   (Followers: 7)
Autophagy     Hybrid Journal   (Followers: 2)
Avances en Quimica     Open Access   (Followers: 1)
Biochemical Pharmacology     Hybrid Journal   (Followers: 10)
Biochemistry     Full-text available via subscription   (Followers: 282)
Biochemistry Insights     Open Access   (Followers: 5)
Biochemistry Research International     Open Access   (Followers: 6)
BioChip Journal     Hybrid Journal  
Bioinorganic Chemistry and Applications     Open Access   (Followers: 9)
Bioinspired Materials     Open Access   (Followers: 5)
Biointerface Research in Applied Chemistry     Open Access   (Followers: 2)
Biointerphases     Open Access   (Followers: 1)
Biology, Medicine, & Natural Product Chemistry     Open Access   (Followers: 1)
Biomacromolecules     Full-text available via subscription   (Followers: 19)
Biomass Conversion and Biorefinery     Partially Free   (Followers: 10)
Biomedical Chromatography     Hybrid Journal   (Followers: 6)
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 3)
BioNanoScience     Partially Free   (Followers: 4)
Bioorganic & Medicinal Chemistry     Hybrid Journal   (Followers: 108)
Bioorganic & Medicinal Chemistry Letters     Hybrid Journal   (Followers: 93)
Bioorganic Chemistry     Hybrid Journal   (Followers: 10)
Biopolymers     Hybrid Journal   (Followers: 18)
Biosensors     Open Access   (Followers: 2)
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 1)
Bitácora Digital     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 2)
Bulletin of the Chemical Society of Japan     Full-text available via subscription   (Followers: 24)
Bulletin of the Korean Chemical Society     Hybrid Journal   (Followers: 1)
C - Journal of Carbon Research     Open Access   (Followers: 3)
Cakra Kimia (Indonesian E-Journal of Applied Chemistry)     Open Access  
Canadian Association of Radiologists Journal     Full-text available via subscription   (Followers: 2)
Canadian Journal of Chemistry     Hybrid Journal   (Followers: 10)
Canadian Mineralogist     Full-text available via subscription   (Followers: 3)
Carbohydrate Research     Hybrid Journal   (Followers: 26)
Carbon     Hybrid Journal   (Followers: 67)
Catalysis for Sustainable Energy     Open Access   (Followers: 6)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 8)
Catalysis Science and Technology     Free   (Followers: 6)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 3)
Catalysts     Open Access   (Followers: 7)
Cellulose     Hybrid Journal   (Followers: 7)
Cereal Chemistry     Full-text available via subscription   (Followers: 4)
ChemBioEng Reviews     Full-text available via subscription   (Followers: 1)
ChemCatChem     Hybrid Journal   (Followers: 8)
Chemical and Engineering News     Free   (Followers: 12)
Chemical Bulletin of Kazakh National University     Open Access  
Chemical Communications     Full-text available via subscription   (Followers: 70)
Chemical Engineering Research and Design     Hybrid Journal   (Followers: 23)
Chemical Research in Chinese Universities     Hybrid Journal   (Followers: 3)
Chemical Research in Toxicology     Full-text available via subscription   (Followers: 19)
Chemical Reviews     Full-text available via subscription   (Followers: 173)
Chemical Science     Open Access   (Followers: 21)
Chemical Technology     Open Access   (Followers: 16)
Chemical Vapor Deposition     Hybrid Journal   (Followers: 5)
Chemical Week     Full-text available via subscription   (Followers: 8)
Chemie in Unserer Zeit     Hybrid Journal   (Followers: 55)
Chemie-Ingenieur-Technik (Cit)     Hybrid Journal   (Followers: 25)
ChemInform     Hybrid Journal   (Followers: 8)
Chemistry & Biodiversity     Hybrid Journal   (Followers: 6)
Chemistry & Biology     Full-text available via subscription   (Followers: 30)
Chemistry & Industry     Hybrid Journal   (Followers: 5)
Chemistry - A European Journal     Hybrid Journal   (Followers: 147)
Chemistry - An Asian Journal     Hybrid Journal   (Followers: 15)
Chemistry and Materials Research     Open Access   (Followers: 18)
Chemistry Central Journal     Open Access   (Followers: 4)
Chemistry Education Research and Practice     Free   (Followers: 5)
Chemistry in Education     Open Access   (Followers: 9)
Chemistry International     Hybrid Journal   (Followers: 2)
Chemistry Letters     Full-text available via subscription   (Followers: 45)
Chemistry of Materials     Full-text available via subscription   (Followers: 250)
Chemistry of Natural Compounds     Hybrid Journal   (Followers: 9)
Chemistry World     Full-text available via subscription   (Followers: 22)
Chemistry-Didactics-Ecology-Metrology     Open Access  
ChemistryOpen     Open Access   (Followers: 2)
Chemkon - Chemie Konkret, Forum Fuer Unterricht Und Didaktik     Hybrid Journal  
Chemoecology     Hybrid Journal   (Followers: 2)
Chemometrics and Intelligent Laboratory Systems     Hybrid Journal   (Followers: 15)
Chemosensors     Open Access  
ChemPhysChem     Hybrid Journal   (Followers: 9)
ChemPlusChem     Hybrid Journal   (Followers: 2)
ChemTexts     Hybrid Journal  
CHIMIA International Journal for Chemistry     Full-text available via subscription   (Followers: 2)
Chinese Journal of Chemistry     Hybrid Journal   (Followers: 6)
Chinese Journal of Polymer Science     Hybrid Journal   (Followers: 10)
Chromatographia     Hybrid Journal   (Followers: 24)
Chromatography Research International     Open Access   (Followers: 7)
Clay Minerals     Full-text available via subscription   (Followers: 9)
Cogent Chemistry     Open Access  
Colloid and Interface Science Communications     Open Access  
Colloid and Polymer Science     Hybrid Journal   (Followers: 10)
Colloids and Surfaces B: Biointerfaces     Hybrid Journal   (Followers: 8)
Combinatorial Chemistry & High Throughput Screening     Hybrid Journal   (Followers: 3)
Combustion Science and Technology     Hybrid Journal   (Followers: 18)
Comments on Inorganic Chemistry: A Journal of Critical Discussion of the Current Literature     Hybrid Journal   (Followers: 2)
Composite Interfaces     Hybrid Journal   (Followers: 6)
Comprehensive Chemical Kinetics     Full-text available via subscription   (Followers: 2)
Comptes Rendus Chimie     Full-text available via subscription  
Comptes Rendus Physique     Full-text available via subscription   (Followers: 1)
Computational and Theoretical Chemistry     Hybrid Journal   (Followers: 9)
Computational Biology and Chemistry     Hybrid Journal   (Followers: 12)
Computational Chemistry     Open Access   (Followers: 2)
Computers & Chemical Engineering     Hybrid Journal   (Followers: 9)
Coordination Chemistry Reviews     Full-text available via subscription   (Followers: 2)
Copernican Letters     Open Access  
Critical Reviews in Biochemistry and Molecular Biology     Hybrid Journal   (Followers: 5)
Crystal Structure Theory and Applications     Open Access   (Followers: 3)
CrystEngComm     Full-text available via subscription   (Followers: 11)
Current Catalysis     Hybrid Journal   (Followers: 2)
Current Metabolomics     Hybrid Journal   (Followers: 5)
Current Opinion in Colloid & Interface Science     Hybrid Journal   (Followers: 9)
Current Research in Chemistry     Open Access   (Followers: 8)
Current Science     Open Access   (Followers: 57)
Dalton Transactions     Full-text available via subscription   (Followers: 19)
Detection     Open Access   (Followers: 2)
Developments in Geochemistry     Full-text available via subscription   (Followers: 2)
Diamond and Related Materials     Hybrid Journal   (Followers: 12)
Dislocations in Solids     Full-text available via subscription  
Doklady Chemistry     Hybrid Journal  
Drying Technology: An International Journal     Hybrid Journal   (Followers: 4)
Eclética Química     Open Access   (Followers: 1)
Ecological Chemistry and Engineering S     Open Access   (Followers: 4)
Ecotoxicology and Environmental Contamination     Open Access  
Educación Química     Open Access   (Followers: 1)
Education for Chemical Engineers     Hybrid Journal   (Followers: 5)
EJNMMI Radiopharmacy and Chemistry     Open Access  
Elements     Full-text available via subscription   (Followers: 2)
Environmental Chemistry     Hybrid Journal   (Followers: 9)
Environmental Chemistry Letters     Hybrid Journal   (Followers: 4)
Environmental Science & Technology Letters     Full-text available via subscription   (Followers: 5)

        1 2 3 | Last

Journal Cover Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement
  [SJR: 0.378]   [H-I: 30]   [26 followers]  Follow
    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 0949-1775 - ISSN (Online) 1432-0517
   Published by Springer-Verlag Homepage  [2355 journals]
  • Congress, conferences, workshops and courses
    • Pages: 169 - 170
      PubDate: 2017-06-01
      DOI: 10.1007/s00769-017-1267-7
      Issue No: Vol. 22, No. 3 (2017)
       
  • Congress, conferences, workshops and courses
    • Pages: 109 - 109
      PubDate: 2017-04-01
      DOI: 10.1007/s00769-017-1259-7
      Issue No: Vol. 22, No. 2 (2017)
       
  • Uncertainty evaluation for the determination of the dissolved fraction of
           sulpiride content in tablets
    • Authors: Biying Du
      Abstract: The aim of this work was to establish a mathematical model to identify the main source of measurement uncertainty, quantify each uncertainty component, and calculate the combined and expanded uncertainties for determination of the fraction of sulpiride dissolved from tablets by UV spectrophotometry. The uncertainties on the absorbance (sample and standard), volumetric flasks and volumetric pipettes have important influence on the overall uncertainty. The average sulpiride fraction released from six tablets was 75.5 %, with an expanded uncertainty of 3.7 % (k = 2). Uncertainty is a relevant tool in assessment of compliance or non-compliance of in-process and final pharmaceutical products. Evaluation of the uncertainty of the dissolution measurement contributes to scientific explanation and interpretation of testing data, and ensures the results to be more accurate, impartial and convincing when testing a sample against specification or legislation.
      PubDate: 2017-06-29
      DOI: 10.1007/s00769-017-1273-9
       
  • A statistical procedure for the assessment of bias in analytical methods
           using conditional probabilities
    • Authors: Robert B. Frenkel; Ian Farrance
      Abstract: A new approach is described for the simultaneous treatment of bias and imprecision in clinical chemistry. The approach makes use of the general law of conditional probabilities. The result is a density distribution of the measurand that incorporates both imprecision and bias and avoids the contentious linear combination of these quantities as a ‘total error’. This leads naturally to a figure-of-merit in proficiency testing or method comparison that has intuitive visual appeal. We also discuss an established figure-of-merit in proficiency testing, namely the E n number.
      PubDate: 2017-06-29
      DOI: 10.1007/s00769-017-1274-8
       
  • Full method validation in clinical chemistry
    • Authors: Elvar Theodorsson; Bertil Magnusson
      Abstract: Clinical chemistry is subject to the same principles and standards used in all branches of metrology in chemistry for validation of measurement methods. The use of measuring systems in clinical chemistry is, however, of exceptionally high volume, diverse and involves many laboratories and systems. Samples for measuring the same measurand from a certain patient are likely to encounter several measuring systems over time in the process of diagnosis and treatment of his/her diseases. Several challenges regarding method validation across several laboratories are therefore evident, but rarely addressed in current standards and accreditation practices. The purpose of this is paper to address some of these challenges, making a case that appropriate conventional method validation performed by the manufacturers fulfils only a part of the investigation needed to show that they are fit for purpose in different healthcare circumstances. Method validation across several laboratories using verified commercially available measuring systems can only be performed by the laboratories—users themselves in their own circumstances, and need to be emphasised more by the laboratories themselves and accreditation authorities alike.
      PubDate: 2017-06-29
      DOI: 10.1007/s00769-017-1275-7
       
  • Evaluation and optimisation of methylene blue removal measurement
           uncertainty in photodegradation studies
    • Authors: Nuno F. Rosa; O. C. Monteiro; M. Filomena Camões; Ricardo. J. N. Bettencourt da Silva
      Abstract: The photodegradation of carcinogenic and teratogenic organic contaminants, such as active substances of medicines or preservatives of personal care products, not removed from wastewaters by conventional treatments, is a promising solution to reduce the impact of such emissions. Nevertheless, new catalysts need to be developed to make this technology feasible. Catalysts performance can be assessed from photodegradation tests using degradation markers such as methylene blue. The difference between the photodegradation kinetic constants of two catalytic alternatives is meaningful if its absolute value is larger than the expanded uncertainty of the difference, which results from the combination of relevant measurement uncertainty components, namely pollutant concentration before and after depletion and irradiation time. This work presents algorithms for estimating differences of kinetic constants of methylene blue removal, with uncertainty, implemented in a user-friendly MS Excel spreadsheet. The developed measurement models allow the optimisation and reliable comparison of kinetic constants. This tool is particularly useful to distinguish small efficiency differences of catalysts with equivalent production and use costs. If a portion of the methylene blue solution subjected to irradiation is used to calibrate the spectrometer between 0.26 mg L−1 and 1.3 mg L−1 in a wavelength interval between 550 nm and 700 nm, if the solution irradiation time is larger than 11 min and the irradiated solution is quantified after dilution with negligible uncertainty, it is possible to distinguish the difference of kinetic constants between 0.11 ms−1 and 0.56 ms−1.
      PubDate: 2017-06-06
      DOI: 10.1007/s00769-017-1272-x
       
  • How to encompass an uncorrected bias into the expanded uncertainty with a
           fixed coverage probability: calculation procedures
    • Authors: Václav Synek
      Abstract: The practice in analytical and medical laboratories often necessitates evaluating the uncertainty of measurement in such a way that incorporates the bias in the expanded uncertainty of measurement instead of correcting for it. This paper presents a complete procedure for calculating the coverage interval that is delimited with one of these approaches. The obtained interval is symmetrical with respect to the uncorrected measured value (x) and has a determined coverage probability (p) under a given bias (b) and combined standard uncertainty (u c ); the approach is denoted by U e (p). A possibility of this approach was suggested by Synek (Talanta 65:829–837, 7). The stated procedure enables to choose frequently used coverage probabilities (mainly 95 % and 99 %). The calculation of the U e (p) expanded uncertainty requires quantifying a factor that multiplies u c . Its values depend on p, on b/u c and also on the effective number of degrees of freedom (ν) of u c , especially at ν of a small size; these values can be found in the attached tables. Since this accurate calculation can be qualified as too complex, a simplification is recommended by using two approximations that are applicable provided ν ≥ 6.
      PubDate: 2017-06-03
      DOI: 10.1007/s00769-017-1268-6
       
  • Development of milk powder reference material and its use for evaluation
           of laboratory performance on analysis of mandatory nutrients for nutrition
           labelling in Thailand
    • Authors: Kunchit Judprasong; Prapasri Puwastien; Jutharat Supanuwat; Sitima Jittinandana; Naruemol Pinprapai
      Abstract: This study investigated the laboratory performance on the analyses of mandatory nutrients for nutrition labelling in Thailand and aimed to upgrade the proficiency test (PT) material into a reference material (RM). This milk powder with sufficient homogeneity and multiple nutrient compositions provided an acceptable PT material. Twenty ISO 17025 accredited laboratories participated in this study, and analytical performance was investigated using ISO 17043 and ISO 13528 standards. Satisfactory performance ( z ≤ 2, for both within- and between-laboratory variations) was found among participating laboratories on the analyses of total fat, saturated fat, cholesterol, protein, sugar, sodium, vitamin B1, vitamin B2, calcium, iron, moisture, and ash. The values of these nutrients (mean and standard deviation) were applied to upgrade the PT material to be used as a reference material. For a trial, moisture, vitamin B1, and vitamin B2 were selected as three representative nutrients to develop reference values as mean and uncertainty following ISO Guides 34 and 35 for RM production. The mean of moisture, vitamin B1, and vitamin B2 values of 2.34 g/(100 g), 0.64 mg/(100 g), and 0.78 mg/(100 g) were obtained with the relative expanded uncertainty of 12.2 %, 12.7 %, and 9.7 %, respectively. The developed RM can be used as quality control sample or as PT material with reference nutrient values among the laboratories in Thailand.
      PubDate: 2017-05-26
      DOI: 10.1007/s00769-017-1269-5
       
  • Evolution of quality on pharmaceutical design: regulatory requirement?
    • Authors: AnaCerúlia Moraes doCarmo; Marcilio S. S. Cunha-Filho; Guilherme Martins Gelfuso; Tais Gratieri
      Abstract: Quality by design (QbD) concept was first outlined by quality pioneer Joseph M. Juran, who believed quality could be designed into a product, preventing, therefore, most quality problems, normally related to the way quality was planned. This concept, as others related to quality conception and management, has already been applied by other industries, as automotive, and later introduced to pharmaceutical industry through US Food and Drug Administration and The International Council on Harmonization of Technical Requirements for Medicinal Products for Human Use guidelines. Brazil mostly applies statistical quality control and still does not have specific regulations regarding QbD, neither other countries in Latin America. Thus, the current stage of pharmaceutical quality regulation in Latin America must be understood to implement better strategies that can positively affect the development of drug products to reach advanced levels of quality. This article reviews aspects related to quality of pharmaceutics and assesses data to analyze whether Brazilian pharmaceutical industry can adapt to this scenario as a pilot for other South American countries.
      PubDate: 2017-05-26
      DOI: 10.1007/s00769-017-1270-z
       
  • Combined uncertainty factor for sampling and analysis
    • Authors: Michael H. Ramsey; Stephen L. R. Ellison
      Abstract: Measurement uncertainty that arises from primary sampling can be expressed as an uncertainty factor, which recognises its sometimes approximately log-normal probability distribution. By contrast, uncertainty arising from chemical analysis is usually expressed as relative uncertainty, based upon the assumptions of its approximately normal distribution. A new method is proposed that enables uncertainty from these two sources, expressed in these different ways, to be combined to produce an estimate of the total combined uncertainty of the measurement values that result when the measurement process is considered as a whole.
      PubDate: 2017-05-26
      DOI: 10.1007/s00769-017-1271-y
       
  • Identifying the critical cut-points of a quality control process for
           serological assays: results from parametric and semiparametric regression
           models
    • Authors: Handan Wand; Wayne Dimech; Robert Freame; Kathy Smeh
      Abstract: Quality control programs rely on continuous monitoring which may generate large volume of complex data. Assessing the precision of a biological assay using quality control processes is essential to evaluate the daily variations in a testing system. Variation can be introduced by reagents, instruments and operators, as well as biological changes in the populations screened. We have proposed a statistical analysis framework which combines novel statistical analysis and visualization techniques to determine the functional relationship between the quality control and blood donor’s negative results. Flexible semiparametric regression techniques were used to determine the functional relationships between blood donor’s hepatitis B surface antigen and anti-HIV test results and the reactivity of quality control samples over a period of 9 months. We demonstrated that the use of semiparametric regression models in conjunction with the probabilistic approaches may bring comprehensive insight into understanding the significant temporal features of the data and its impact on patient’s test results. In the absence of clinically relevant cut-point(s), data-driven methodologies, such as the one described in this study may potentially have significant benefits and widespread applications.
      PubDate: 2017-05-19
      DOI: 10.1007/s00769-017-1265-9
       
  • Establishment of an analytical method for accurate purity evaluations of
           acylcarnitines by using quantitative 1 H NMR spectroscopy
    • Authors: Naoki Saito; Takeshi Saito; Taichi Yamazaki; Yoshinori Fujimine; Toshihide Ihara
      Abstract: Recently, it has become possible to examine metabolism abnormalities by detecting increases in specific acylcarnitines in blood tests of newborn babies using tandem mass spectrometer. However, acylcarnitine standard solutions with metrological traceability to the International System of Units (SI) for accurate calibration of tandem mass spectrometer are not yet available worldwide. In this study, we examined a quantitative 1H NMR procedure for obtaining accurate and SI-traceable purity evaluations of acylcarnitines having different numbers of carbon atoms as each raw material for their standard solutions. In particular, the solvent composition and measurement temperature were optimized to reduce the influence of water signal overlapping on analyte signals. It was found that, when the signal of that 1H which directly bound to the asymmetric carbon of the acylcarnitine is the target signal, it was possible to reduce overlapping of the water signal on the target signal by using deuterium oxide as a solvent. On the other hand, in the case of an acylcarnitine that was poorly soluble in deuterium oxide, it was possible to reduce overlapping of the water signal on the target signal by adding an appropriate amount of deuterium oxide to methanol-d 4 in which the acylcarnitine had high solubility. At this time, the optimum mixing volume ratio of methanol-d 4/deuterium would be 80:20. The overlapping of the water signal could be also reduced when the measurement temperature was 15 °C to 40 °C. When the measurement temperature was an around room temperature (in this study, 25 °C), fine shimming could be performed easily. Therefore, the optimum temperature would be 25 °C, because fine shimming was essential to quantify any signal area accurately. Finally, this study confirmed that accurate values with SI traceability could be obtained at about 1 % or less expanded uncertainty for five kinds of acylcarnitines.
      PubDate: 2017-04-29
      DOI: 10.1007/s00769-017-1263-y
       
  • European analytical column number 45
    • Authors: Wolfgang Buchberger; Slavica Razic
      PubDate: 2017-04-28
      DOI: 10.1007/s00769-017-1266-8
       
  • Note on the correction of negative measured values if the measurand is
           positive or 0 with known probability
    • Authors: Peter-Th. Wilrich
      Abstract: Often the amount of a substance or the activity of radionuclides in a sample is measured indirectly as the difference between signal and noise, i.e. the difference between the measured value obtained at the sample and that obtained at a sample not containing the substance or the radionuclides (blank sample). The difference can be negative, especially if the concentration or the activity is low. Since a negative measurement result for a nonnegative measurand does not make sense, measured values must be corrected to nonnegative measurement results. We deal with the situation in which it is known that the measurand is 0 with a probability \(p_0\) that is a priori known, and that the standard deviation \(\sigma\) of the measurement is known. For this case Korun, Vodenik and Zorko extend an earlier paper by Korun and Zorko and derive the mean of the posterior distribution as a Bayesian estimator of the measurand. We offer an estimator that is based on the posterior probability \(\hat{p}_0\) of the measurand being 0. If \(\hat{p}_0 > 1 - \hat{p}_0\) it is 0 and otherwise the mode of the posterior distribution. This estimate is easier to calculate and less biased than that of Korun et al.
      PubDate: 2017-04-26
      DOI: 10.1007/s00769-017-1264-x
       
  • Do accredited laboratories perform better in proficiency testing than
           non-accredited laboratories?
    • Authors: Ken Middlebrook
      Abstract: The CALA proficiency testing programme has been in operation since 1991. As CALA is also an accreditation body, every result reported as part of the CALA PT schemes is identified as being from a CALA accredited laboratory or not from a CALA accredited laboratory. For this examination, a data set is a group of analytical results for a single measurand, from a single test item, from a single PT round. Following the identification of data sets that contain a minimum of ten results from an accredited laboratory, and ten results from a non-accredited laboratory, the remaining data comprised 252 analyte/matrix combinations, 14 844 individual data sets and 1 124 630 participant results. Assigned values and standard deviations of proficiency assessment were calculated using Algorithm A from ISO 13528, and z-scores calculated for all reported results, regardless of accreditation status. Comparisons were made of z-scores between accredited and non-accredited laboratories for the data as a whole, as well as for subsets of the data partitioned into groups such as inorganic tests, organic tests and microbiological tests. In all cases examined, the percentage of both Questionable and Unsatisfactory performance was higher for non-accredited laboratories than for accredited laboratories. A comparison was also made between accredited and non-accredited laboratories of the percentage of consecutive Unsatisfactory performance for the same analyte over a ten year period. Finally, comparisons were made for the first, second and third time participation to assess the impact of PT scheme familiarity. This examination shows that accredited laboratories continually outperform non-accredited laboratories as a group.
      PubDate: 2017-04-21
      DOI: 10.1007/s00769-017-1262-z
       
  • Mass emissions and carbon trading: a critical review of available
           reference methods for industrial stack flow measurement
    • Authors: C. Dimopoulos; R. A. Robinson; M. D. Coleman
      Abstract: Flow measurements in industrial ducts and stacks are combined with pollutant or greenhouse gas concentrations to deduce mass emissions. These are then used to populate pollutant emission inventories and are traded under emissions trading schemes. Reference methods for flow are described in ISO 10780 and more recently in EN ISO 16911-1. This paper discusses the key differences between the two standards. We consider sources of error in flow measurement and discuss how each standard addresses them. We find that EN ISO 16911-1 introduces a series of improvements that when combined provide critical uncertainty gains that support compliance with the EU’s Emissions Trading System (EU ETS). All these areas are either not addressed or only partially dealt with in ISO 10780. More specifically, EN ISO 16911-1, (a) specifies a wider range of reference techniques enabling the optimal one to be used for different flue gas environments. (b) Provides a method to correct for cyclonic flow effects. (c) Addresses measurement assembly misalignment and specifies tolerance values for it and (d) provides wall effect correction factors. Most importantly, it has been validated through laboratory and field work. However, the quality control specified in EN ISO 16911-1 is more suitable for measurements to support EU ETS requirements and at times can be too onerous for pollutant mass emission reporting that will usually have less stringent uncertainty requirements.
      PubDate: 2017-03-24
      DOI: 10.1007/s00769-017-1261-0
       
  • Organisation of proficiency schemes by testing and calibration
           laboratories
    • Authors: Rodrigo Leão Mianes; Carla Schwengber ten Caten
      Abstract: Each year, an increasing demand for proficiency testing is seen in the world. Participating in this type of activity has been adopted by testing and calibration laboratories, accredited under the ISO/IEC 17025 standard (General requirements for the competence of testing and calibration laboratories), as a means to meet normative and regulatory requirements. Nevertheless, the availability of proficiency testing schemes organised by providers accredited under the ISO/IEC 17043 standard (Conformity assessment—General requirements for proficiency testing) has been insufficient, which poses challenges to laboratories. Considering the similarities between requirements present in both standards, which would allow for their coexistence in a management system, this paper presents an analysis of potential conflicts of interest within an organisation operating simultaneously as proficiency testing provider and testing and calibration laboratory. Aspects of confidentiality, impartiality and undue internal pressures are discussed, and a procedure is proposed to mitigate such conflicts through a web application that codifies the relationship between laboratories and results with no human interaction. In order to minimise possible subjective aspects, the study was validated by a group of metrology specialists. It was concluded that the proposed simultaneous operation is possible and can effectively contribute to reduce shortage in the availability of such a service.
      PubDate: 2017-03-17
      DOI: 10.1007/s00769-017-1260-1
       
  • PAH analysis in biomass combustion wastes: an approach to evaluate bias
           and precision of analytical results using routine samples
    • Authors: Susana García-Alonso; Rosa María Pérez-Pastor; David Sanz-Rivera; Enrique Rojas-García; Jesús Rodríguez-Maroto
      Abstract: The aim of this work was to optimize and evaluate an analytical procedure to determine selected polycyclic aromatic hydrocarbons (PAHs) using real samples. Samples of ash were collected during biomass combustion tests under different operating conditions during one week. PAHs were quantified using liquid chromatography with fluorescence detection. Samples were extracted by a simple sonication/agitation method using small amounts of solvent and samples. This paper includes how the performance (bias and precision) of the proposed method was estimated from the analyses of samples. In order to obtain reliable data, we estimated the possible presence of two types of analytical bias: bias proportional bias to the level of analyte, expressed as recovery, and constant bias, comparing results from analyses of different ash masses. Apart from bias studies, the analytical variability was also evaluated as intermediate precision from the overall analyses of different routine samples, with different mass fraction levels and test dates. Intermediate precision values were reduced among 5 % to 10 % when measures on the optimized sample sizes and similar mass fraction levels were taken. The use of samples is rarely applied to assess trueness of analytical methods. Therefore, the presented findings can be considered as an interesting contribution to the analytical chemistry research field.
      PubDate: 2017-03-14
      DOI: 10.1007/s00769-017-1257-9
       
  • Use of ETAAS, FAAS and ICP-OES for production and post-certification
           monitoring of a multielemental certified reference material according to
           national regulation limits for elements in drinking water
    • Authors: Christian Uribe; Elmer Carrasco; Steve Acco
      Abstract: This paper describes the development of a certified reference material (CRM), produced in the National Institute of Quality from Peru (INACAL) in order to provide a tool for assurance and quality control of nine elements in drinking water. Atomic absorption spectrometry (ETAAS or FAAS) allowed for measurements during the 18-month certification process. ETAAS or ICP optical emission spectrometry was used for 24-month post-certification monitoring measurements. CRM production took into account requirements of ISO Guides 34 and 35 for production of reference materials and criteria of the JCGM GUM and Eurachem QUAM Guides for uncertainty calculation. Mass fractions chosen for batch gravimetric preparation were based on the maximum permissible limits of the National Regulation for Drinking Water Quality in Peru. Characterization analytical measurements were performed using the bracketing calibration technique, applying a randomized 10-replicate measurement sequence and adjusting (matrix matching) the nitric acid concentration for all measured solutions. Characterization resulted from the combination of gravimetric preparation and analytical atomic absorption measurement results. Main sources of uncertainty were identified from the homogeneity study, characterization and the stability study. Expanded relative uncertainties for the assigned mass fractions (ng/g) of Pb, Cd, Ni, As, Cr, Cu, Zn, Mn and Al in the CRM produced were between 0.8 % and 1.9 %. INACAL’s capability to achieve the stated uncertainties has been confirmed through successfully participating in a comparison of the Inter-American Metrology System (SIM-QM-S2). All declared results (ETAAS and FAAS) were comparable to those declared by primary methods of other participants in this comparison.
      PubDate: 2017-03-09
      DOI: 10.1007/s00769-017-1258-8
       
  • ETV-ICP-OES: a useful technique for homogeneity study of trace element in
           metals—application to the homogeneity study of 23 elements in
           electrolytic copper
    • Authors: Thomas Bacquart; Juergen Hassler; Thomas Vogt; Peter Perzl; Sascha Steigerwald; Wieland Schmidt; Marc Sterckx; Thomas P. J. Linsinger
      Abstract: Solid sampling techniques can perform multi-elemental determination on large number of samples in repeatable conditions without sample preparation, making them valuable tools for the homogeneity testing of reference materials. Even if techniques like glow discharge mass spectrometry are often used for large samples, the application to small chips was not well documented due to the small sample mass. This study compares two analytical methods for homogeneity studies of Ag, Al, As, Au, Bi, Cd, Co, Cr, Fe, In, Mg, Mn, Ni, P, Pb, Sb, Se, Si, Sn, Te, Ti, Zn and Zr in two electrolytic copper materials in the format of chips (ERM-EB074C and ERM-EB075C): (a) digestion methods: acid dissolution followed by ICP-MS or ICP-OES and (b) solid sampling method using electrothermal vaporization coupled with inductively coupled plasma optical emission spectrometry (ETV-ICP-OES). The same 10 units were analysed in 3–5 replicates by the different methods. ETV-ICP-OES was more precise than digestion methods with relative standard deviations of less than 8 % for most elements. The between-unit uncertainties determined by ETV-ICP-OES were lower than the values reported by the digestion methods. ETV-ICP-OES is a very interesting alternative to the digestion methods for large homogeneity study involving large number of trace elements. Also, the intrinsic sample inhomogeneity (minimum sample intake) was re-evaluated using the results of ETV-ICP-OES (sample intake: 3 mg) for the two materials. The minimum sample intake of several elements (e.g. Au Pb, Se and Te) was evaluated to be lower than the 10 mg reported for the two materials.
      PubDate: 2017-03-06
      DOI: 10.1007/s00769-017-1254-z
       
 
 
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