JournalTOCs

Indonesian Journal of Chemistry
Journal Prestige (SJR): 0.209

Citation Impact (citeScore): 1
Number of Followers: 1

This is an Open Access Journal

Open Access journal
ISSN (Print) 1411-9420 - ISSN (Online) 2460-1578
Published by Universitas Gadjah Mada

[48 journals]

Selection of the Parameters in the Synthesis of Ethylenediamine-Folate
Using the Plackett Burman Design
- Authors: Erianti Siska Purnamasari, Linda Septiana, Ari Hardianto, Ukun Mochammad Syukur Soedjanaatmadja, Anni Anggraeni, Husein Hernadi Bahti
  Abstract: This study is concerned with synthesizing ethylenediamine-folate (EDA-Folate), which will then be used as a precursor in synthesizing Gd-PEG-DOTA-Folate, a novel targeted-contrast agent for the diagnosis of cancer, employing the Magnetic Resonance Imaging method. This study aims to determine all the parameters affecting the synthesis of EDA-Folate using the Plackett Burman design. The synthesis method included activation of folic acid using dicyclohexylcarbodiimide and N-Hydroxysuccinimide to result in NHS-Folate, followed by conjugation of ethylenediamine with NHS-Folate to produce EDA-Folate. Analysis of the reaction product confirmed that the reaction product was EDA-Folate. From the resulted data, it can also be concluded that there were four significant parameters (out of the ten parameters studied) in the synthesis of EDA-Folate (with its value presented in the bracket), i.e., time inactivation of NHS-Folate (24 h), stirring rate inactivation of NHS-Folate (300 rpm), the mole of EDA (12 moles), and time of EDA-Folate (12 h). Moreover, the value or desirability of the experimental design was found to be 0.875 (which is < 1.0), meaning that the design will produce optimal conditions and thus the optimal yield of the reaction.
  PubDate: 2022-05-19
  DOI: 10.22146/ijc.68313
  Issue No: Vol. 22, No. 2 (2022)
Synthesis and Cytotoxic Test of Halogen-Substituted Chalcone Against MCF-7
Breast Cancer Cells
- Authors: Eti Meirina Brahmana, Jamaran Kaban, Ginda Haro, Mimpin Ginting
  Abstract: A series of chalcones was synthesized to be (E)-1-(4-chlorophenyl)-3-p-tolyprop-2-en-1-on (1), (E)-1-(4-chlorophenyl)-3-(4-tolyprophenyl) prop-2-en-1-on (2), (E)-1-(3-bromophenyl)-3-p-tolylprop-2-en-1-on (3), and (E)-1-(3-bromophenyl)-3-(4-isopropyl phenyl) prop-2-en-1-on (4) using irradiate microwave method with reaction time from 3, 6, and 8 min at 800 °C and 700 W. The compounds were characterized using TLC, UV-Vis, FTIR, 1H-NMR, and evaluated MCF-7 cancer cell cytotoxic test with Presto BlueTM. All compounds produced were in the form of yellow crystals. The results showed that compounds 2, 3, and 4 were potentially a Como prevention agent and inhibit cell proliferation with IC50 values of 37.24, 422.22, and 22.41 ppm, respectively. While compound 1 had IC50 1,484.75 and no cytotoxic effect. Further tests should be carried out for compounds 2, 3, and 4 against normal cells to measure the compound's safety for normal cells.
  PubDate: 2022-05-19
  DOI: 10.22146/ijc.69991
  Issue No: Vol. 22, No. 2 (2022)
Design, Synthesis, and Anti-mycobacterial Evaluation of New
3,5-Disubstituted-pyrazole-1-carbothioamides
- Authors: Kok Tong Wong, Hasnah Osman, Thaigarajan Parumasivam, Muhammad Solehin Abd Ghani, Mohd. Zaheen Hassan, Unang Supratman, Mohamad Nurul Azmi Mohamad Taib
  Abstract: Two series of new 3,5-disubstituted-pyrazole-1-carbothioamides (4a-f and 5a-e) were designed and synthesized through condensation reaction between chalcones and thiosemicarbazides under alkaline condition via cyclocondensation reaction. The structures have been elucidated by Fourier-transform infrared (FTIR), High-resolution mass spectrometry (HRMS), one- and two-dimensional nuclear magnetic resonance (NMR) analyses. These compounds were assayed for in vitro anti-tuberculosis activity against Mycobacterium tuberculosis H37Ra using the Tetrazolium microplate assay (TEMA) method. As a result, six compounds (i.e., 4a, 4d, 4f, 5a, 5c, and 5d) showed a weak activity with minimum inhibition concentration (MIC) between 650–530 μM, and other compounds showed no inhibition against MTB. In addition, all tested compounds also did not show any cidal effects for minimum bactericidal concentration (MBC), even at the highest test concentration.
  PubDate: 2022-05-17
  DOI: 10.22146/ijc.70243
  Issue No: Vol. 22, No. 2 (2022)
Adsorption of Bemacid Red by Poly Tetra (Ethylene Glycol) Dimethacrylate
Crosslinked with 2-Hydroxypropyl Methacrylate Hydrogels: Equilibrium and
Kinetic Studies
- Authors: Asmahane Fasla, Zoubida Seghier, Abdelkader Iddou, Laura Caserta
  Abstract: Besides others, textile industries are the primary sources of discharging a massive amount of highly colored wastewater. Adsorption can be considered the most economically favorable technology method for removing dyes from wastewater. This paper reports the synthesis of Poly tetra (ethyleneglycol) dimethacrylate crosslinked with 2-hydroxypropyl methacrylate (Poly (TtEGDMA-cross-2-HPMA)) hydrogelsand its application as a novel sorbent to remove bemacid red (ET2) dye from aqueous solution under various operating conditions. The equilibrium adsorption capacity was found 142.82–883.60 mg ET2 g–1 of 1% TtEGDMA. The adsorbent was characterized using Fourier transform infrared radiation (FTIR) and 13carbon solid-state nuclear magnetic resonance spectra (13C-NMR). The effects of the experimental parameters include dye concentration and crosslinked agent concentration. The kinetic sorption uptake for ET2 by Poly (TtEGDMA-cross-2-HPMA) at various initial dye concentrations was analyzed by pseudo-first and pseudo-second models. Two sorption isotherms, namely the Langmuir and Freundlich isotherms, were applied to the sorption equilibrium data. The sorption kinetics of ET2 onto the hydrogels followed the pseudo-second-order kinetics model (R2 = 0.999) and the adsorption equilibrium data obeyed the Langmuir isotherm model (R2 = 0.999). It can be concluded that Poly (TtEGDMA-cross-2-HPMA) is an alternative economic sorbent to more costly adsorbents used for dye removal in wastewater treatment processes.
  PubDate: 2022-05-09
  DOI: 10.22146/ijc.69548
  Issue No: Vol. 22, No. 2 (2022)
A New Flow Injection System with Merging-Zone Technique for the
Determination of Copper(II) by Neocuproine Reagent in Aqueous Solution
- Authors: Ahmed Saleh Farhood, Dakhil Nassir Taha
  Abstract: A fast, simple, and high throughput sample merging-zone flow injection design was developed to determine copper(II) in aqueous solution. The procedure is based on the reduction of copper(II) to copper(I) by uric acid followed by a direct reaction with Neocuproine reagent (NC). The orange-yellow complex that forms absorb light at 454 nm. All conditions of the new flow injection unit were investigated. The analytical curve of copper(II) was linear with (r2) value of 0.9978, in the range of 0.4 to 40 mg/L with a detection limit of 0.1 mg/L and a quantification limit of 0.3 mg/L. the molar absorptivity was 1.661 × 105 L/mol cm and the recovery range was between 104.9 and 97%. The homemade acrylic valve was low-cost with zero dead volume and high repeatability (n = 7) with an RSD of 2.31%. The dispersion coefficient values were 1.8,1.62, and 1.31 for the concentrations of 5, 15, and 25 mg/L, respectively. The sample throughput was 69 h–1.
  PubDate: 2022-04-26
  DOI: 10.22146/ijc.70799
  Issue No: Vol. 22, No. 2 (2022)