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  Subjects -> CHEMISTRY (Total: 845 journals)
    - ANALYTICAL CHEMISTRY (51 journals)
    - CHEMISTRY (595 journals)
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CHEMISTRY (595 journals)                  1 2 3 | Last

Showing 1 - 200 of 735 Journals sorted alphabetically
2D Materials     Hybrid Journal   (Followers: 8)
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 26)
ACS Catalysis     Full-text available via subscription   (Followers: 34)
ACS Chemical Neuroscience     Full-text available via subscription   (Followers: 18)
ACS Combinatorial Science     Full-text available via subscription   (Followers: 23)
ACS Macro Letters     Full-text available via subscription   (Followers: 24)
ACS Medicinal Chemistry Letters     Full-text available via subscription   (Followers: 39)
ACS Nano     Full-text available via subscription   (Followers: 244)
ACS Photonics     Full-text available via subscription   (Followers: 11)
ACS Synthetic Biology     Full-text available via subscription   (Followers: 21)
Acta Chemica Iasi     Open Access   (Followers: 2)
Acta Chimica Sinica     Full-text available via subscription   (Followers: 1)
Acta Chimica Slovaca     Open Access   (Followers: 1)
Acta Chromatographica     Full-text available via subscription   (Followers: 9)
Acta Facultatis Medicae Naissensis     Open Access  
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 5)
Acta Scientifica Naturalis     Open Access   (Followers: 2)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 5)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 8)
Adsorption Science & Technology     Full-text available via subscription   (Followers: 5)
Advanced Functional Materials     Hybrid Journal   (Followers: 51)
Advanced Science Focus     Free   (Followers: 3)
Advances in Chemical Engineering and Science     Open Access   (Followers: 56)
Advances in Chemical Science     Open Access   (Followers: 13)
Advances in Chemistry     Open Access   (Followers: 15)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Enzyme Research     Open Access   (Followers: 9)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 8)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 16)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 9)
Advances in Materials Physics and Chemistry     Open Access   (Followers: 21)
Advances in Nanoparticles     Open Access   (Followers: 15)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15)
Advances in Polymer Science     Hybrid Journal   (Followers: 41)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 17)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Science and Technology     Full-text available via subscription   (Followers: 12)
African Journal of Bacteriology Research     Open Access  
African Journal of Chemical Education     Open Access   (Followers: 2)
African Journal of Pure and Applied Chemistry     Open Access   (Followers: 7)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 67)
American Journal of Biochemistry and Molecular Biology     Open Access   (Followers: 14)
American Journal of Chemistry     Open Access   (Followers: 27)
American Journal of Plant Physiology     Open Access   (Followers: 14)
American Mineralogist     Hybrid Journal   (Followers: 14)
Analyst     Full-text available via subscription   (Followers: 40)
Angewandte Chemie     Hybrid Journal   (Followers: 203)
Angewandte Chemie International Edition     Hybrid Journal   (Followers: 219)
Annales UMCS, Chemia     Open Access   (Followers: 1)
Annals of Clinical Chemistry and Laboratory Medicine     Open Access   (Followers: 4)
Annual Reports in Computational Chemistry     Full-text available via subscription   (Followers: 3)
Annual Reports Section A (Inorganic Chemistry)     Full-text available via subscription   (Followers: 4)
Annual Reports Section B (Organic Chemistry)     Full-text available via subscription   (Followers: 8)
Annual Review of Chemical and Biomolecular Engineering     Full-text available via subscription   (Followers: 12)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 15)
Anti-Infective Agents     Hybrid Journal   (Followers: 3)
Antiviral Chemistry and Chemotherapy     Hybrid Journal  
Applied Organometallic Chemistry     Hybrid Journal   (Followers: 7)
Applied Spectroscopy     Full-text available via subscription   (Followers: 23)
Applied Surface Science     Hybrid Journal   (Followers: 28)
Arabian Journal of Chemistry     Open Access   (Followers: 6)
ARKIVOC     Open Access   (Followers: 2)
Asian Journal of Biochemistry     Open Access   (Followers: 1)
Atomization and Sprays     Full-text available via subscription   (Followers: 4)
Australian Journal of Chemistry     Hybrid Journal   (Followers: 7)
Autophagy     Hybrid Journal   (Followers: 2)
Avances en Quimica     Open Access   (Followers: 1)
Biochemical Pharmacology     Hybrid Journal   (Followers: 10)
Biochemistry     Full-text available via subscription   (Followers: 310)
Biochemistry Insights     Open Access   (Followers: 6)
Biochemistry Research International     Open Access   (Followers: 6)
BioChip Journal     Hybrid Journal  
Bioinorganic Chemistry and Applications     Open Access   (Followers: 9)
Bioinspired Materials     Open Access   (Followers: 5)
Biointerface Research in Applied Chemistry     Open Access   (Followers: 2)
Biointerphases     Open Access   (Followers: 1)
Biology, Medicine, & Natural Product Chemistry     Open Access   (Followers: 1)
Biomacromolecules     Full-text available via subscription   (Followers: 19)
Biomass Conversion and Biorefinery     Partially Free   (Followers: 10)
Biomedical Chromatography     Hybrid Journal   (Followers: 6)
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 3)
BioNanoScience     Partially Free   (Followers: 5)
Bioorganic & Medicinal Chemistry     Hybrid Journal   (Followers: 118)
Bioorganic & Medicinal Chemistry Letters     Hybrid Journal   (Followers: 91)
Bioorganic Chemistry     Hybrid Journal   (Followers: 10)
Biopolymers     Hybrid Journal   (Followers: 18)
Biosensors     Open Access   (Followers: 2)
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 1)
Bitácora Digital     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 2)
Bulletin of the Chemical Society of Japan     Full-text available via subscription   (Followers: 24)
Bulletin of the Korean Chemical Society     Hybrid Journal   (Followers: 1)
C - Journal of Carbon Research     Open Access   (Followers: 3)
Cakra Kimia (Indonesian E-Journal of Applied Chemistry)     Open Access  
Canadian Association of Radiologists Journal     Full-text available via subscription   (Followers: 3)
Canadian Journal of Chemistry     Hybrid Journal   (Followers: 10)
Canadian Mineralogist     Full-text available via subscription   (Followers: 4)
Carbohydrate Research     Hybrid Journal   (Followers: 26)
Carbon     Hybrid Journal   (Followers: 66)
Catalysis for Sustainable Energy     Open Access   (Followers: 7)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 8)
Catalysis Science and Technology     Free   (Followers: 7)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 3)
Catalysts     Open Access   (Followers: 8)
Cellulose     Hybrid Journal   (Followers: 7)
Cereal Chemistry     Full-text available via subscription   (Followers: 4)
ChemBioEng Reviews     Full-text available via subscription   (Followers: 1)
ChemCatChem     Hybrid Journal   (Followers: 8)
Chemical and Engineering News     Free   (Followers: 14)
Chemical Bulletin of Kazakh National University     Open Access  
Chemical Communications     Full-text available via subscription   (Followers: 72)
Chemical Engineering Research and Design     Hybrid Journal   (Followers: 24)
Chemical Research in Chinese Universities     Hybrid Journal   (Followers: 3)
Chemical Research in Toxicology     Full-text available via subscription   (Followers: 20)
Chemical Reviews     Full-text available via subscription   (Followers: 182)
Chemical Science     Open Access   (Followers: 22)
Chemical Technology     Open Access   (Followers: 16)
Chemical Vapor Deposition     Hybrid Journal   (Followers: 5)
Chemical Week     Full-text available via subscription   (Followers: 8)
Chemie in Unserer Zeit     Hybrid Journal   (Followers: 58)
Chemie-Ingenieur-Technik (Cit)     Hybrid Journal   (Followers: 26)
ChemInform     Hybrid Journal   (Followers: 8)
Chemistry & Biodiversity     Hybrid Journal   (Followers: 6)
Chemistry & Biology     Full-text available via subscription   (Followers: 30)
Chemistry & Industry     Hybrid Journal   (Followers: 5)
Chemistry - A European Journal     Hybrid Journal   (Followers: 146)
Chemistry - An Asian Journal     Hybrid Journal   (Followers: 15)
Chemistry and Materials Research     Open Access   (Followers: 20)
Chemistry Central Journal     Open Access   (Followers: 4)
Chemistry Education Research and Practice     Free   (Followers: 5)
Chemistry in Education     Open Access   (Followers: 9)
Chemistry International     Hybrid Journal   (Followers: 2)
Chemistry Letters     Full-text available via subscription   (Followers: 44)
Chemistry of Materials     Full-text available via subscription   (Followers: 258)
Chemistry of Natural Compounds     Hybrid Journal   (Followers: 9)
Chemistry World     Full-text available via subscription   (Followers: 22)
Chemistry-Didactics-Ecology-Metrology     Open Access   (Followers: 1)
ChemistryOpen     Open Access   (Followers: 2)
Chemkon - Chemie Konkret, Forum Fuer Unterricht Und Didaktik     Hybrid Journal  
Chemoecology     Hybrid Journal   (Followers: 4)
Chemometrics and Intelligent Laboratory Systems     Hybrid Journal   (Followers: 15)
Chemosensors     Open Access  
ChemPhysChem     Hybrid Journal   (Followers: 9)
ChemPlusChem     Hybrid Journal   (Followers: 2)
ChemTexts     Hybrid Journal  
CHIMIA International Journal for Chemistry     Full-text available via subscription   (Followers: 2)
Chinese Journal of Chemistry     Hybrid Journal   (Followers: 6)
Chinese Journal of Polymer Science     Hybrid Journal   (Followers: 10)
Chromatographia     Hybrid Journal   (Followers: 24)
Clay Minerals     Full-text available via subscription   (Followers: 10)
Cogent Chemistry     Open Access  
Colloid and Interface Science Communications     Open Access  
Colloid and Polymer Science     Hybrid Journal   (Followers: 10)
Colloids and Surfaces B: Biointerfaces     Hybrid Journal   (Followers: 7)
Combinatorial Chemistry & High Throughput Screening     Hybrid Journal   (Followers: 4)
Combustion Science and Technology     Hybrid Journal   (Followers: 18)
Comments on Inorganic Chemistry: A Journal of Critical Discussion of the Current Literature     Hybrid Journal   (Followers: 2)
Composite Interfaces     Hybrid Journal   (Followers: 6)
Comprehensive Chemical Kinetics     Full-text available via subscription   (Followers: 2)
Comptes Rendus Chimie     Full-text available via subscription  
Comptes Rendus Physique     Full-text available via subscription   (Followers: 1)
Computational and Theoretical Chemistry     Hybrid Journal   (Followers: 9)
Computational Biology and Chemistry     Hybrid Journal   (Followers: 12)
Computational Chemistry     Open Access   (Followers: 2)
Computers & Chemical Engineering     Hybrid Journal   (Followers: 9)
Coordination Chemistry Reviews     Full-text available via subscription   (Followers: 3)
Copernican Letters     Open Access   (Followers: 1)
Critical Reviews in Biochemistry and Molecular Biology     Hybrid Journal   (Followers: 5)
Crystal Structure Theory and Applications     Open Access   (Followers: 4)
CrystEngComm     Full-text available via subscription   (Followers: 13)
Current Catalysis     Hybrid Journal   (Followers: 2)
Current Metabolomics     Hybrid Journal   (Followers: 5)
Current Opinion in Colloid & Interface Science     Hybrid Journal   (Followers: 9)
Current Opinion in Molecular Therapeutics     Full-text available via subscription   (Followers: 17)
Current Research in Chemistry     Open Access   (Followers: 8)
Current Science     Open Access   (Followers: 61)
Dalton Transactions     Full-text available via subscription   (Followers: 23)
Detection     Open Access   (Followers: 2)
Developments in Geochemistry     Full-text available via subscription   (Followers: 2)
Diamond and Related Materials     Hybrid Journal   (Followers: 12)
Dislocations in Solids     Full-text available via subscription  
Doklady Chemistry     Hybrid Journal  
Drying Technology: An International Journal     Hybrid Journal   (Followers: 4)
Eclética Química     Open Access   (Followers: 1)
Ecological Chemistry and Engineering S     Open Access   (Followers: 3)
Ecotoxicology and Environmental Contamination     Open Access  
Educación Química     Open Access   (Followers: 1)
Education for Chemical Engineers     Hybrid Journal   (Followers: 5)
EJNMMI Radiopharmacy and Chemistry     Open Access  
Elements     Full-text available via subscription   (Followers: 3)
Environmental Chemistry     Hybrid Journal   (Followers: 7)
Environmental Chemistry Letters     Hybrid Journal   (Followers: 4)
Environmental Science & Technology Letters     Full-text available via subscription   (Followers: 5)

        1 2 3 | Last

Journal Cover Advances in Heterocyclic Chemistry
  [SJR: 0.497]   [H-I: 31]   [9 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 0065-2725
   Published by Elsevier Homepage  [3051 journals]
  • Tautomerism and Structure of Azoles: Nuclear Magnetic Resonance
           Spectroscopy
    • Authors: Lyudmila I. Larina
      Abstract: Publication date: Available online 5 August 2017
      Source:Advances in Heterocyclic Chemistry
      Author(s): Lyudmila I. Larina
      This review provides comprehensive data (from the author's work and the literature) on tautomerism of pyrazoles, imidazoles, 1,2,3- and 1,2,4-triazoles, tetrazoles, benzimidazoles, benzimidazolones, benzotriazoles, and related compounds by multinuclear 1H, 13C, 15N nuclear magnetic resonance (NMR) spectroscopy. Emphasis is given to studies of azoles by multinuclear dynamic NMR spectroscopy because prototropic transformations of almost all azoles in solution proceed so quickly. Quantum-chemical investigations of tautomeric azoles are covered in detail. Critical analysis of literature data on the tautomerism of azoles is presented. Theoretical studies of structure and reactivity of azoles are most intriguing because correct interpretation of their chemical behavior and biological activity depends on an understanding the factors determining relative stability of their tautomers. 15N NMR spectroscopy is the most reliable and fast technique for structural and tautomeric determination of nitrogen-containing heteroaromatic compounds.

      PubDate: 2017-08-28T06:21:52Z
      DOI: 10.1016/bs.aihch.2017.06.003
       
  • Heterocycles Incorporating a Pentacoordinated, Hypervalent Phosphorus Atom
    • Authors: Dorota Krasowska; Patrycja Pokora-Sobczak; Aleksandra Jasiak; Józef Drabowicz
      Abstract: Publication date: Available online 17 July 2017
      Source:Advances in Heterocyclic Chemistry
      Author(s): Dorota Krasowska, Patrycja Pokora-Sobczak, Aleksandra Jasiak, Józef Drabowicz
      This chapter presents the synthesis of heterocycles with a hypervalent, pentacoordinated phosphorus atom. It is divided into two sections. The first is devoted to the preparation of pentavalent, pentacoordinated, hypervalent monocyclic phosphoranes, and their selected interconversions. The second section, concerning bicyclic heterocycles, describes the synthesis and reactivity of all kinds of bicyclic phosphoranes. The phenomenon of chirality for this group of organophosphorus derivatives is also briefly discussed.

      PubDate: 2017-07-23T19:13:10Z
      DOI: 10.1016/bs.aihch.2017.06.002
       
  • Organometallic Complexes of Azines
    • Authors: Alexander P. Sadimenko; Omobola O. Okoh
      Abstract: Publication date: Available online 12 July 2017
      Source:Advances in Heterocyclic Chemistry
      Author(s): Alexander P. Sadimenko, Omobola O. Okoh
      Organometallic complexes of practically unsubstituted (non-chelating) azines and their benzannulated derivatives, possible N-heterocyclic carbenes containing at least one double bond, and boron-, boron–nitrogen, silicon-, tri- and hexaphosphorus analogs of azines are considered in the view of their synthetic availability, coordination modes, and possible application in catalysis and materials chemistry.

      PubDate: 2017-07-23T19:13:10Z
      DOI: 10.1016/bs.aihch.2017.06.001
       
  • 2-Pyridone Methides (2-Methylene-1,2-dihydropyridines) and Benzo-Fused
           Analogs11Part 1 (Adv. Heterocycl. Chem., 122, 141 (2017)) contains
           Sections 1 and 2 (Introduction and Synthesis, resp.), including Schemes
           1–50 (Formulas 1–303) and Tables 1 and 2. Part 2: Structure,
           Reactivity, and Application
    • Authors: Gunther Fischer
      Abstract: Publication date: Available online 21 April 2017
      Source:Advances in Heterocyclic Chemistry
      Author(s): Gunther Fischer
      One main focus of the review (Part 2) is spectral and physicochemical properties of both N-unsubstituted methides and anhydrobases, including tautomerism and stability. In the sections on chemical reactivity, reactions upon the α-position as well as ring formation and transformation are dominant. Finally, recently published applications are reviewed.

      PubDate: 2017-04-24T20:45:29Z
       
  • Advances in Heterocyclic Chemistry
    • Abstract: Publication date: 2017
      Source:Advances in Heterocyclic Chemistry, Volume 123


      PubDate: 2017-04-03T16:58:05Z
       
  • Editorial Advisory Board
    • Abstract: Publication date: 2017
      Source:Advances in Heterocyclic Chemistry, Volume 123


      PubDate: 2017-04-03T16:58:05Z
       
  • Advances in Heterocyclic Chemistry
    • Abstract: Publication date: 2017
      Source:Advances in Heterocyclic Chemistry, Volume 122


      PubDate: 2017-03-20T13:54:36Z
       
  • Editorial Advisory Board
    • Abstract: Publication date: 2017
      Source:Advances in Heterocyclic Chemistry, Volume 122


      PubDate: 2017-03-20T13:54:36Z
       
  • Synthesis and Applications of Thiophene Derivatives as Organic Materials
    • Authors: G. Barbarella; M. Zangoli; F. Di Maria
      Abstract: Publication date: Available online 24 February 2017
      Source:Advances in Heterocyclic Chemistry
      Author(s): G. Barbarella, M. Zangoli, F. Di Maria
      Thiophene-based compounds have acquired increasing importance in materials science and technology, owing to their multiple functional properties, chemical robustness, and versatility. Research studies involving thiophene-based materials are highly interdisciplinary and range from organic electronics, in which the semiconducting properties of these materials are exploited in devices such as thin film field-effect transistors and solar cells, to bioimaging, in which their optical properties are exploited to monitor biological events involving proteins and DNA. Since all fields are concerned with the synthesis of new molecular structures, this chapter also deals with the most recent advances in the synthesis of oligo- and polythiophenes.

      PubDate: 2017-02-24T10:54:36Z
      DOI: 10.1016/bs.aihch.2017.01.001
       
  • The Synthesis and Chemistry of Azolobenzodiazepines
    • Authors: Hemming
      Abstract: Publication date: Available online 8 February 2017
      Source:Advances in Heterocyclic Chemistry
      Author(s): K. Hemming
      Approaches to the synthesis and applications of the azolobenzodiazepines have been reviewed with a particular focus on the imidazo-, pyrrolo-, pyrazolo-, and triazolo-fused systems. The review covers N-arylation, metal-catalyzed coupling processes, radiolabeled synthesis, multicomponent reactions, and the synthesis of biologically active molecules. Key natural products covered are the fuligocandins, the circumdatins, and other pyrrolobenzodiazepines. The review also covers well-known pharmaceutical substances such as flumazenil, midazolam, SJG-136, and alprazolam.

      PubDate: 2017-02-10T13:10:10Z
       
  • A Synopsis of the Properties and Applications of Heteroaromatic Rings in
           Medicinal Chemistry
    • Authors: N.A. Meanwell
      Abstract: Publication date: Available online 9 January 2017
      Source:Advances in Heterocyclic Chemistry
      Author(s): N.A. Meanwell
      Five- and six-membered heteroaromatic rings and their benzo-fused homologues are well established as important structural elements in drug design and are well represented in approved drugs. The key properties of these heterocycles that are of interest to medicinal chemists include lipophilicity, pK a, aromaticity, ionization potential, H-bond acceptor, and H-bond donor (NH, OH, CH) capability, electron withdrawing effects, dipole values, and bond angles. The judicious and productive application of azoles and azines in drug design requires an understanding of the intrinsic physical chemical properties of the individual heterocycles and how these interact with substituents. In this article, the key properties of azole and azine heterocycles are summarized followed by a synopsis of applications where some of these factors play a role in drug–target interactions and/or potency.

      PubDate: 2017-01-15T19:21:36Z
      DOI: 10.1016/bs.aihch.2016.11.002
       
  • Advances in Heterocyclic Chemistry
    • Abstract: Publication date: 2017
      Source:Advances in Heterocyclic Chemistry, Volume 121


      PubDate: 2017-01-06T17:19:45Z
       
  • Editorial Advisory Board
    • Abstract: Publication date: 2017
      Source:Advances in Heterocyclic Chemistry, Volume 121


      PubDate: 2017-01-06T17:19:45Z
       
  • Synthesis of Heterocycles From Amidrazones
    • Authors: A.A. Aly; M. Ramadan; H.M. Fatthy
      Abstract: Publication date: Available online 29 December 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): A.A. Aly, M. Ramadan, H.M. Fatthy
      Amidrazones have the structure R1NC(R2)=NNHR3. The ease of forming CN and CN bonds is reflected in their extensive use for the preparation of heterocycles. While the terminal nitrogen atom of the hydrazone moiety in amidrazones (CNNH2) is the most powerful nucleophilic center, the other two nitrogen atoms can also act as nucleophiles and thus complete cyclization processes. In this chapter, we update the utility of amidrazones in heterocycles synthesis.

      PubDate: 2017-01-06T17:19:45Z
      DOI: 10.1016/bs.aihch.2016.11.001
       
  • Diketene as Privileged Synthon in the Syntheses of Heterocycles Part 1:
           Four- and Five-Membered Ring Heterocyclesa
    • Authors: M.M. Heravi; B. Talaei
      Abstract: Publication date: Available online 30 November 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): M.M. Heravi, B. Talaei
      4-Methyleneoxetan-2-one (Diketene or DK) consists of a four-membered lactone ring adjacent to a methylene function. It can be used as a versatile precursor for the syntheses of wide range of heterocycles including fused and spiral biheterocycles. In this chapter, we try to cover the structural features and reactivity of DK, and underscore its applications as a flexible and useful synthon in the syntheses of four- and five-membered heterocycles as well as a wide variety of fused or spiro heterocycles. This chapter as part 1 is divided in accordance with the ring sizes and subdivided according to types, numbers, and arrangements of heteroatoms.

      PubDate: 2016-12-05T16:58:07Z
      DOI: 10.1016/bs.aihch.2016.10.003
       
  • 2-Pyridone Methides (2-Methylene-1,2-dihydropyridines) and Benzo-Fused
           Analogs—Part 1: Synthesis
    • Authors: Fischer
      Abstract: Publication date: Available online 30 August 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): G. Fischer
      The review (Part 1) deals with the synthesis of 2-pyridone methides and benzo-fused analogs. Methides that are unsubstituted at the nitrogen atom are mainly synthesized from the corresponding pyridine bases by reactions at o- or α-positions, from N-oxides or by ring formation or transformation. N-Substituted so-called anhydrobases mostly originate from quaternary salts either by deprotonation or by reactions at o- or α-positions.

      PubDate: 2016-09-02T19:45:40Z
       
  • The Evolving Landscape of Heterocycles in Drugs and Drug Candidates
    • Authors: Tony Y. Zhang
      Abstract: Publication date: Available online 8 August 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): Tony Y. Zhang
      Substructure analysis of approved drugs and drug candidates in clinical trials was performed to illustrate the evolving roles of heterocycles in pharmaceutical research. The increasing representation of biaryls and heteroaromatics is noted and attributed predominantly to their better accessibility brought upon by advances in metal catalyzed cross-coupling and hetero-coupling reactions. Possible future focus of academic research is proposed for improving structural diversity and probability of success for drug research, and enhancing the impact of heterocyclic chemistry to the development of new medicines.

      PubDate: 2016-08-13T10:07:30Z
      DOI: 10.1016/bs.aihch.2016.05.001
       
  • Heterocyclic Building Blocks for Organic Semiconductors
    • Authors: Xikang Zhao; Saadia T. Chaudhry; Jianguo Mei
      Abstract: Publication date: Available online 29 June 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): Xikang Zhao, Saadia T. Chaudhry, Jianguo Mei
      Organic semiconductors are an important class of functional materials. Numerous molecular and polymeric organic semiconductors have been developed for their great potentials in next generation flexible and printed electronics. In this chapter, the authors review some of the most popular heterocyclic building blocks and their chemistry. These building blocks are organized based on the heteroatom(s) that are present in their structures, including sulfur-, nitrogen-, silicon-, phosphorus-, and boron-containing heterocycles.

      PubDate: 2016-07-11T21:23:33Z
      DOI: 10.1016/bs.aihch.2016.04.009
       
  • Thiazole and Isothiazole Ring–Containing Compounds in Crop
           Protection
    • Authors: Peter Maienfisch; Andrew J.F. Edmunds
      Abstract: Publication date: Available online 21 June 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): Peter Maienfisch, Andrew J.F. Edmunds
      Organic compounds containing five-membered aromatic heterocyclic rings play an important role in life science. Among them thiazole and isothiazole heterocycles are present in many pharmaceutical drugs and crop protection compounds and have sparked over past years an enormous interest on these scaffolds. In agrochemicals these moieties are found in 11 commercial products as well as in two development compounds. A thiazole moiety is present in nine currently marketed agrochemicals, namely the insecticides thiamethoxam and clothianidin; the fungicides thiabendazole, thifluzamide, ethaboxam, benthiavalicarb, and oxathiapiprolin; the nematicide fluensulfone; as well as in the development compound dicloromezotiaz. One compound, the fungicide isotianil, contains an isothiazole ring; two compounds a benzothiazole ring, namely the herbicides methabenzthiazuron and mefenacet; and one compound, the former nematicide development compound benclothiaz, contains a benzisothiazole ring. Interestingly thiazole and isothiazole heterocycles are much less frequently found in agrochemicals than pyridine and pyrazole despite their bioisosteric relationship, which may indicate that these heterocycles have still not been explored to their full scope in crop protection lead discovery and optimization. Detailed information on the discovery, synthesis, and the structure–activity relationships of thiazole- and isothiazole-containing agrochemicals is provided in this review.

      PubDate: 2016-07-11T21:23:33Z
      DOI: 10.1016/bs.aihch.2016.04.010
       
  • Heterogeneously Catalyzed Synthesis of Heterocyclic Compounds
    • Authors: Colin H. McAteer; Ramiah Murugan; Yarlagadda V. Subba Rao
      Abstract: Publication date: Available online 17 May 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): Colin H. McAteer, Ramiah Murugan, Yarlagadda V. Subba Rao
      This chapter covers the synthesis of heterocyclic compounds using heterogeneous catalysts from the perspective of practicing industrial chemists. Before discussing the synthesis of various heterocycles using heterogeneous catalysts a brief discussion on catalyst choice and classification of reaction chemistry is provided. Next, the synthesis of commercially important heterocycles from acyclic precursors is provided starting with the three-membered aziridines and epoxides. For the four-membered heterocycles, propiolactone synthesis is discussed followed by the five-membered pyrroles, furans, and thiophenes. Within the five-membered ring category of heterocycles, the benz-fused pyrrole, indole and rings with more than one heteroatom such as pyrazoles, imidazoles, thiazoles, oxa- and thio-diazoles synthesis are also discussed. Similar to the five-membered ring heterocycles, the six-membered heterocycle syntheses discussed are pyridines, picolines, quinolines, acridines, pyrimidines, pyrazines, triazines, coumarins, etc. Finally a small section on process and economics consideration is provided along with final comments.

      PubDate: 2016-05-19T18:38:13Z
      DOI: 10.1016/bs.aihch.2016.03.003
       
  • Nitrogen-Rich Azoles as High Density Energy Materials: Reviewing the
           Energetic Footprints of Heterocycles
    • Authors: Ping Yin; Jean'ne M. Shreeve
      Abstract: Publication date: Available online 17 May 2016
      Source:Advances in Heterocyclic Chemistry
      Author(s): Ping Yin, Jean'ne M. Shreeve
      In this contribution, recent developments of azole-based high energy density materials are reviewed. A variety of azoles, e.g., pyrazole, imidazole, triazole, and tetrazole, were used as nitrogen-rich backbones and were functionalized with explosophores. The synthetic methods, experimental properties, and theoretical calculations are discussed leading to panoramas of these promising energetic materials.

      PubDate: 2016-05-19T18:38:13Z
      DOI: 10.1016/bs.aihch.2016.04.004
       
 
 
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