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Universal Journal of Chemistry
Number of Followers: 1

This is an Open Access Journal

Open Access journal
ISSN (Print) 2332-3019 - ISSN (Online) 2332-3027
Published by Horizon Research Publishing

[51 journals]

Biological Activities of Metal Complexes with Rutin and Bio-Conjugate of
Citrus Extract
- Abstract: Publication date: Jul 2020
  Source:Universal Journal of Chemistry Volume 7 Number 1 Om Prakash Babita Belal Jyotsna Dhanik Anil Verma Hem C Joshi and Vivekanand The main aim of this study is to determine the changes occurred in the antioxidant capacity and UV-protection capacity of rutin with a different redox-potential metal cation. The complexes were characterized by UV-Visible and IR spectroscopy. Rutin belongs to the flavonols and it is a glycoside form of quercetin. Chelate formation is a result of interaction of rutin with metal ions. The chelation of metals can be crucial in the prevention of radical generation, which damages target biomolecules. The interactions between flavonoids and transition metal ions to form complexes that prevent the participation of metal ions in free radical generating processes, thus exhibit an anti-oxidant behavior, metal-flavonoid complexes various biological and pharmacological activities. The coordination of Rutin (Rut) with Rut-Zr, Rut-Mo, Rut-Zn, Rut-Cu, Rut-Ni, Rut-Fe, Cit-Zn, Cit-Mo, Cit-Zr, Cit-Cu, Cit-Fe, and Cit-Ni may simulate the catalyzed centre of the hyperoxide dismutase in the metal coordinate structure, thus displayed the DPPH, hydroxyl radical scavenging activity, metal chelating, and nitric oxide (NO) and superoxide dismutase (SOD) radical scavenging. Therefore, the metal flavonoid complexes are very helpful in discovery and development of new drugs.
  PubDate: Jul 2020

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