Subjects -> CHEMISTRY (Total: 1001 journals)
    - ANALYTICAL CHEMISTRY (59 journals)
    - CHEMISTRY (726 journals)
    - CRYSTALLOGRAPHY (23 journals)
    - ELECTROCHEMISTRY (28 journals)
    - INORGANIC CHEMISTRY (45 journals)
    - ORGANIC CHEMISTRY (49 journals)
    - PHYSICAL CHEMISTRY (71 journals)

CHEMISTRY (726 journals)                  1 2 3 4 | Last

Showing 1 - 200 of 735 Journals sorted alphabetically
Accounts of Materials Research     Hybrid Journal  
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 36)
ACS Applied Polymer Materials     Hybrid Journal   (Followers: 15)
ACS Catalysis     Hybrid Journal   (Followers: 78)
ACS Chemical Neuroscience     Hybrid Journal   (Followers: 25)
ACS Combinatorial Science     Hybrid Journal   (Followers: 25)
ACS Macro Letters     Hybrid Journal   (Followers: 34)
ACS Materials Letters     Open Access   (Followers: 4)
ACS Medicinal Chemistry Letters     Hybrid Journal   (Followers: 49)
ACS Nano     Hybrid Journal   (Followers: 452)
ACS Photonics     Hybrid Journal   (Followers: 19)
ACS Symposium Series     Full-text available via subscription   (Followers: 3)
ACS Synthetic Biology     Hybrid Journal   (Followers: 40)
Acta Chemica Iasi     Open Access   (Followers: 8)
Acta Chemica Malaysia     Open Access  
Acta Chimica Slovaca     Open Access   (Followers: 4)
Acta Chimica Slovenica     Open Access   (Followers: 2)
Acta Chromatographica     Full-text available via subscription   (Followers: 9)
Acta Facultatis Medicae Naissensis     Open Access   (Followers: 1)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 10)
Acta Scientifica Naturalis     Open Access   (Followers: 3)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 9)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 10)
Adsorption Science & Technology     Open Access   (Followers: 9)
Advanced Electronic Materials     Hybrid Journal   (Followers: 7)
Advanced Functional Materials     Hybrid Journal   (Followers: 81)
Advanced Journal of Chemistry, Section A     Open Access   (Followers: 15)
Advanced Journal of Chemistry, Section B     Open Access   (Followers: 14)
Advanced Science Focus     Free   (Followers: 7)
Advanced Theory and Simulations     Hybrid Journal   (Followers: 5)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Chemical Engineering and Science     Open Access   (Followers: 108)
Advances in Chemical Science     Open Access   (Followers: 50)
Advances in Chemistry     Open Access   (Followers: 39)
Advances in Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 21)
Advances in Drug Research     Full-text available via subscription   (Followers: 27)
Advances in Environmental Chemistry     Open Access   (Followers: 11)
Advances in Enzyme Research     Open Access   (Followers: 13)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 8)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 20)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 11)
Advances in Materials Physics and Chemistry     Open Access   (Followers: 35)
Advances in Nanoparticles     Open Access   (Followers: 20)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 20)
Advances in Polymer Science     Hybrid Journal   (Followers: 54)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 19)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 22)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 7)
Advances in Science and Technology     Full-text available via subscription   (Followers: 17)
Aerosol Science and Engineering     Hybrid Journal  
African Journal of Bacteriology Research     Open Access  
African Journal of Chemical Education     Open Access   (Followers: 6)
African Journal of Pure and Applied Chemistry     Open Access   (Followers: 7)
Aggregate     Open Access   (Followers: 3)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 3)
Al-Kimia : Jurnal Penelitian Sains Kimia     Open Access  
Alchemy : Journal of Chemistry     Open Access   (Followers: 5)
Alchemy : Jurnal Penelitian Kimia     Open Access   (Followers: 2)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 2)
Alotrop     Open Access  
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 71)
American Journal of Biochemistry and Molecular Biology     Open Access   (Followers: 24)
American Journal of Chemistry     Open Access   (Followers: 41)
American Journal of Plant Physiology     Open Access   (Followers: 13)
Analyst     Full-text available via subscription   (Followers: 40)
Analytical Science Advances     Open Access   (Followers: 2)
Angewandte Chemie     Hybrid Journal   (Followers: 237)
Angewandte Chemie International Edition     Hybrid Journal   (Followers: 353)
Annales Universitatis Mariae Curie-Sklodowska, sectio AA – Chemia     Open Access   (Followers: 1)
Annals of Clinical Chemistry and Laboratory Medicine     Open Access   (Followers: 8)
Annual Reports in Computational Chemistry     Full-text available via subscription   (Followers: 4)
Annual Reports Section A (Inorganic Chemistry)     Full-text available via subscription   (Followers: 6)
Annual Reports Section B (Organic Chemistry)     Full-text available via subscription   (Followers: 9)
Annual Review of Chemical and Biomolecular Engineering     Full-text available via subscription   (Followers: 13)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 16)
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 2)
Applied Organometallic Chemistry     Hybrid Journal   (Followers: 12)
Applied Spectroscopy     Full-text available via subscription   (Followers: 27)
Applied Surface Science     Hybrid Journal   (Followers: 33)
Arabian Journal of Chemistry     Open Access   (Followers: 6)
ARKIVOC     Open Access   (Followers: 1)
Asian Journal of Applied Chemistry Research     Open Access   (Followers: 2)
Asian Journal of Biochemistry     Open Access   (Followers: 3)
Asian Journal of Chemical Sciences     Open Access   (Followers: 1)
Asian Journal of Chemistry and Pharmaceutical Sciences     Open Access   (Followers: 2)
Asian Journal of Physical and Chemical Sciences     Open Access   (Followers: 3)
Atomization and Sprays     Full-text available via subscription   (Followers: 8)
Australian Journal of Chemistry     Hybrid Journal   (Followers: 7)
Autophagy     Hybrid Journal   (Followers: 7)
Avances en Quimica     Open Access  
Biochemical Pharmacology     Hybrid Journal   (Followers: 11)
Biochemistry     Hybrid Journal   (Followers: 485)
Biochemistry Insights     Open Access   (Followers: 7)
Biochemistry Research International     Open Access   (Followers: 6)
BioChip Journal     Hybrid Journal  
Bioinorganic Chemistry and Applications     Open Access   (Followers: 11)
Biointerface Research in Applied Chemistry     Open Access   (Followers: 3)
Biointerphases     Open Access   (Followers: 1)
Biology, Medicine, & Natural Product Chemistry     Open Access   (Followers: 4)
Biomacromolecules     Hybrid Journal   (Followers: 27)
Biomass Conversion and Biorefinery     Partially Free   (Followers: 11)
Biomedical Chromatography     Hybrid Journal   (Followers: 6)
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 4)
BioNanoScience     Partially Free   (Followers: 6)
Bioorganic & Medicinal Chemistry     Hybrid Journal   (Followers: 216)
Bioorganic & Medicinal Chemistry Letters     Hybrid Journal   (Followers: 88)
Bioorganic Chemistry     Hybrid Journal   (Followers: 10)
Biopolymers     Hybrid Journal   (Followers: 18)
Biosensors     Open Access   (Followers: 4)
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 1)
Bitácora Digital     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Bulletin of Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences     Open Access  
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 1)
Bulletin of the Chemical Society of Japan     Full-text available via subscription   (Followers: 26)
Bulletin of the Korean Chemical Society     Hybrid Journal   (Followers: 1)
C - Journal of Carbon Research     Open Access   (Followers: 5)
Cakra Kimia (Indonesian E-Journal of Applied Chemistry)     Open Access  
Canadian Association of Radiologists Journal     Full-text available via subscription   (Followers: 2)
Canadian Journal of Chemistry     Hybrid Journal   (Followers: 13)
Canadian Mineralogist     Full-text available via subscription   (Followers: 7)
Carbohydrate Polymer Technologies and Applications     Open Access   (Followers: 3)
Carbohydrate Polymers     Hybrid Journal   (Followers: 13)
Carbohydrate Research     Hybrid Journal   (Followers: 26)
Carbon     Hybrid Journal   (Followers: 76)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 9)
Catalysis Science and Technology     Hybrid Journal   (Followers: 13)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 4)
Catalysts     Open Access   (Followers: 14)
Cell Reports Physical Science     Open Access  
Cellulose     Hybrid Journal   (Followers: 17)
Cereal Chemistry     Full-text available via subscription   (Followers: 6)
ChemBioEng Reviews     Full-text available via subscription   (Followers: 3)
ChemCatChem     Hybrid Journal   (Followers: 11)
Chemical and Engineering News     Free   (Followers: 24)
Chemical Bulletin of Kazakh National University     Open Access  
Chemical Communications     Full-text available via subscription   (Followers: 88)
Chemical Engineering Research and Design     Hybrid Journal   (Followers: 28)
Chemical Physics Letters : X     Open Access   (Followers: 4)
Chemical Research in Chinese Universities     Hybrid Journal   (Followers: 4)
Chemical Research in Toxicology     Hybrid Journal   (Followers: 25)
Chemical Reviews     Hybrid Journal   (Followers: 267)
Chemical Science     Open Access   (Followers: 44)
Chemical Science International Journal     Open Access   (Followers: 1)
Chemical Technology     Open Access   (Followers: 71)
Chemical Vapor Deposition     Hybrid Journal   (Followers: 5)
Chemie in Unserer Zeit     Hybrid Journal   (Followers: 56)
Chemie-Ingenieur-Technik (Cit)     Hybrid Journal   (Followers: 23)
ChemInform     Hybrid Journal   (Followers: 9)
Chemistry     Open Access  
Chemistry & Biodiversity     Hybrid Journal   (Followers: 7)
Chemistry & Biology     Full-text available via subscription   (Followers: 31)
Chemistry & Industry     Full-text available via subscription   (Followers: 8)
Chemistry - A European Journal     Hybrid Journal   (Followers: 225)
Chemistry - An Asian Journal     Hybrid Journal   (Followers: 20)
Chemistry Africa : A Journal of the Tunisian Chemical Society     Hybrid Journal  
Chemistry and Materials Research     Open Access   (Followers: 24)
Chemistry Central Journal     Open Access   (Followers: 5)
Chemistry Education Research and Practice     Free   (Followers: 8)
Chemistry Education Review     Open Access   (Followers: 5)
Chemistry in Education     Open Access   (Followers: 9)
Chemistry Letters     Full-text available via subscription   (Followers: 49)
Chemistry of Heterocyclic Compounds     Hybrid Journal   (Followers: 4)
Chemistry of Materials     Hybrid Journal   (Followers: 338)
Chemistry of Natural Compounds     Hybrid Journal   (Followers: 10)
Chemistry World     Full-text available via subscription   (Followers: 20)
Chemistry-Didactics-Ecology-Metrology     Open Access   (Followers: 1)
ChemistryOpen     Open Access   (Followers: 1)
ChemistrySelect     Hybrid Journal  
Chemistry–Methods     Open Access   (Followers: 2)
Chemkon - Chemie Konkret, Forum Fuer Unterricht Und Didaktik     Hybrid Journal  
ChemNanoMat     Hybrid Journal   (Followers: 1)
Chemoecology     Hybrid Journal   (Followers: 3)
Chemometrics and Intelligent Laboratory Systems     Hybrid Journal   (Followers: 14)
Chemosensors     Open Access   (Followers: 1)
ChemPhotoChem     Hybrid Journal  
ChemPhysChem     Hybrid Journal   (Followers: 14)
ChemPlusChem     Hybrid Journal   (Followers: 2)
Chempublish Journal     Open Access   (Followers: 1)
ChemSystemsChem     Hybrid Journal   (Followers: 2)
ChemTexts     Hybrid Journal   (Followers: 1)
CHIMIA International Journal for Chemistry     Open Access   (Followers: 2)
Chinese Journal of Chemistry     Hybrid Journal   (Followers: 6)
Chinese Journal of Polymer Science     Hybrid Journal   (Followers: 13)
Chromatographia     Hybrid Journal   (Followers: 22)
Chromatography     Open Access   (Followers: 3)
Chromatography Research International     Open Access   (Followers: 5)
Ciencia     Open Access   (Followers: 1)
Clay Minerals     Hybrid Journal   (Followers: 9)
Cogent Chemistry     Open Access   (Followers: 3)
Colloid and Interface Science Communications     Open Access  
Colloid and Polymer Science     Hybrid Journal   (Followers: 12)
Colloids and Interfaces     Open Access  
Colloids and Surfaces B: Biointerfaces     Hybrid Journal   (Followers: 8)
Combinatorial Chemistry & High Throughput Screening     Hybrid Journal   (Followers: 4)
Combustion Science and Technology     Hybrid Journal   (Followers: 24)
Comments on Inorganic Chemistry: A Journal of Critical Discussion of the Current Literature     Hybrid Journal   (Followers: 2)

        1 2 3 4 | Last

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Journal Cover
BioNanoScience
Journal Prestige (SJR): 0.308
Citation Impact (citeScore): 1
Number of Followers: 6  
 
  Partially Free Journal Partially Free Journal
ISSN (Print) 2191-1630 - ISSN (Online) 2191-1649
Published by Springer-Verlag Homepage  [2658 journals]
  • Biological Activity of Bicyclic Monoterpene Alcohols

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      Abstract: Abstract The present paper aims to study the biological properties of a series of bicyclic monoterpene alcohols. Firstly, we tested the obtained compounds for fungicidal activity against clinical and reference strains of microscopic fungi. Next, we determined the minimum inhibitory concentration of these compounds comparing to other drugs widely used in practical medicine (fluconazole, terbinafine). At this stage, we found that ( −)-myrtenol (47 MIC and 23.5 μg/ml) exhibits the most promising activity against filamentous and yeast fungi, respectively. Then, we have studied the membrane-protective and antioxidant activities of the obtained compounds and found out that ( −)-cis-verbenol and ( −)-myrtenol exhibit the highest activity on the model of erythrocytes oxidative hemolysis. Interestingly, among all the studied bicyclic monoterpene alcohols, the alcohols of the pinane series have been found to be the most promising. The obtained results from the present study suggest that ( −)-myrtenol would be a leading compound for further studies in terms of possible practical application.
      PubDate: 2021-10-14
       
  • Andean Capuli Fruit Derived Anisotropic Gold Nanoparticles with
           Antioxidant and Photocatalytic Activity

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      Abstract: In this study, gold nanoparticles (CF-AuNPs) were efficiently prepared from aqueous extracts of ripened Capuli (Prunus serotina Ehrh. var. Capuli) fruit by reduction of Au3+ and characterized by a variety of instrumental analyses. A noticeable change in color to ruby red/purple was observed during the formation and stabilization of CF-AuNPs. The UV–Vis spectroscopy has proven the characteristic absorption peaks λmax 544 nm and 934 nm of CF-AuNPs. The biosynthesized CF-AuNPs were spherical and triangular shape confirmed through TEM analysis. The average size of the different CF-AuNPs observed during the DLS and TEM analysis ranged from 30 to 400 nm. The partial crystallinity of CF-AuNPs and their surface binded with phytochemicals is evident from the XRD patterns. Furthermore, synthesized CF-AuNPs have also been applied for antioxidant and photocatalytic applications. This work covers the fundamental principals of green chemistry and joins hands for environmental protection through nanoscience. Graphical abstract
      PubDate: 2021-10-12
       
  • Optimization of the One-Step Green Synthesis of Silver and Gold
           Nanoparticles Using Aqueous Athyrium filix femina Extract Using the
           Taguchi Method

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      PubDate: 2021-10-07
       
  • The Impairing Effect of Oral Aluminum Oxide Nanoparticle on Novel Object
           Recognition Memory Coincides with Akt/GSK-3β Signaling Deregulation in
           Mice Hippocampus

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      Abstract: Abstract The rise in annual production and applications of aluminum nanoparticles leads to elevation of the environmental and occupational exposures to this substance and might raise potential risk to the human health. Aluminum toxicity was suggested to have a role in the pathogenesis of Alzheimer’s disease. Considering the physicochemical properties of aluminum nanoparticle, such as its size, high reactivity, and high specific surface area, there is a concern about the impact of these nanoparticles on brain function. This study was designed to evaluate the effect of a 5-day oral gavage of aluminum oxide nanoparticle (ALNP) on memory and Akt/GSK-3β pathway as well as cleaved caspase-3 signaling in the hippocampus. Adult male NMRI mice were treated with ALNP in doses 5 and 10 mg/kg/oral gavage for 5 days. The novel object recognition (NOR) test session was performed on day 5. Following the behavioral assessments, the hippocampi were assessed for Akt/GSK-3β signaling using western blot technique. The results showed that ALNP oral gavage in doses 5 and 10 mg/kg impairs NOR memory in mice. Furthermore, it decreased the ratio of active to total level of Akt in the hippocampus while increased GSK-3β level in the hippocampus. The memory impairing effect of ALNP coincided with a dose-dependent increase in cleaved caspase-3. This study showed the deregulation of Akt/GSK-3β signaling and apoptosis in the hippocampus following oral aluminum oxide nanoparticle (ALNP) exposure.
      PubDate: 2021-10-06
       
  • Green Synthesis, Characterization and In Vivo Evaluation of White Tea
           Silver Nanoparticles with 5-Fluorouracil on Colorectal Cancer

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      Abstract: Abstract White tea (WT) has the highest amount of catechin which previously was found to enhance anti-cancer activity. To enhance the bioavailability of WT, silver nanoparticle (AgNP) was used to synthesize WT nanoparticle (WTNP). This present study aimed to determine the effectiveness of WTNP alone and co-administered with 5FU in the prophylactic study. WTNP was characterized by UV–Vis spectra, X-ray diffraction (XRD) spectra, transmission electron microscope (TEM) and Fourier-transform infrared spectroscopy (FTIR) and tested for their acute toxicity. In animal studies, all groups except the naïve group were given once a week 65 mg/kg of 1,2-dimethylhydrazine (DMH) subcutaneously, intraperitoneal injection of 50 mg/kg 5FU and daily administration of DMH 50 mg/kg WT and 5FU WTNPs. Aberrant crypt foci (ACF) and histology were determined and analysed. WTNP showed circular and pseudospherical shaped and 25–50 nm size range with no acute toxicity observed on rats. The DMH group was the highest in average ACF count (37.3 ± 3.18), which ACF was shown to decrease using the treatment, WT group (16.67 ± 3.28), 5FU monotherapy (5.67 ± 2.19) and WTFU (6.33 ± 1.33). The highest AC frequency was found at the DMH group (24.67 ± 1.20, 12.67 ± 1.45) compared to other groups. The chemo-suppressive effect of WTNP and WTFU combined effects was observed in the present study. WTNP expresses anti-cancer properties; however, it does not produce any synergistic effect.
      PubDate: 2021-09-30
       
  • Synthesis, Characterization, In Vitro and In Vivo Toxicity of CuO
           Nanoparticles Fabricated Through Rhus punjabensis Leaf Extract

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      Abstract: Abstract Copper nanoparticles were synthesized using Rhus punjabensis leaf extract and assessed for toxicity in vitro against brine shrimp Leishmania tropica and in vivo against Sprague–Dawley rats. The spherical biofunctionalized nanoparticles showed concentration and time-dependent toxicity during in vitro assays. Biocompatibility assessed against Sprague–Dawley rats at 50 and 100 mg/kg (low and high dose) depicted significant variation only in total bilirubin, alanine transaminase, and alkaline phosphatase in both male and female rats at both dose administration; however, non-significant change was recorded on other parameters. Antioxidative enzymes, total proteins, and nitrites also showed significant variation from control in both genders. Histological study revealed alteration in liver, heart, and lungs of male rats on higher dose administration, while female rats on low-dose administration were found safer. The results show that R. punjabensis-mediated CuO nanoparticles are safe at low dose and its application can be expanded as effectual antimicrobial and anticancer agents for pharmaceutical applications.
      PubDate: 2021-09-30
       
  • Chitin Derived Bionanoparticles Evoke Defense Responses in Chickpea: a
           Cost-effective Strategy for Sustainable Chickpea Production

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      Abstract: Abstract To increase the chickpea production, chitosan nanoparticles (CNPs) were prepared from the cell membrane of Fusarium oxysporum f.sp. ciceri (FOC), a causal agent of Fusarium wilt in chickpea, and evaluated for its potential to induce defense responses and plant growth–promoting activity. Chickpea seeds treated with CNP enhanced shoot–root length, leaf number, and leaf size showing intensified photosynthetic activity and higher proline content. Foliar spray of CNP promoted plant growth and elicited the antioxidant enzymes in chickpea under pot condition. A significant increase in protein content was validated by localizing new polypeptides in SDS-PAGE analysis. In addition, CNP treatment showed a remarkable expression of defense enzymes offering protection to plants and also induced four new protease inhibitor isoforms. Furthermore, yield attributes were significantly higher in CNP-treated chickpea plants. As a cost-effective strategy, CNP prepared from cell membrane polymer of a phytopathogen holds great promise in establishing a replacement method for disease management and sustainable chickpea production.
      PubDate: 2021-09-30
       
  • The Effect of Ecdystene on the Activity of Matrix Metalloproteinases in
           Experimental Alloxan Diabetes in Rats

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      Abstract: Abstract The article presents data on the study of the influence of “Ecdystene” on the development of alloxane diabetes, the activity of matrix metalloproteinases, and the content level of their inhibitors. Metalloproteinases are involved in various physiological and pathological processes requiring proliferation and migration of cells and, consequently, restructuring of the extracellular matrix. When applied for treatment during 14 and 21 days, Ecdystene surpasses glucose and Retabolil in terms of hypoglycemic action. In alloxane diabetes, there is a reliable increase in the activity of metalloproteinases, especially on the 14th day of its development. Contrary to comparison preparations, Ecdystene has a more pronounced effect on metalloproteinase activity. Treatment with Ecdystene for 14 and 21 days contributed to an increase in the TIMP-1 content by 2.2 and 1.5 times compared to the untreated group. Glucose and Retabolil increased the content of TIMP-1 on the 7th and 14th days of treatment by 1.26; 0.9 and 1.48; 1.17 times compared to the untreated group. Changes in the activity of MMPs contribute to a decrease in catabolism of the components of the extracellular matrix. To achieve high efficiency in the treatment of diabetes in the clinic, it is recommended to use Ecdystene in combination with other drugs.
      PubDate: 2021-09-29
       
  • The Clinical Case of Successful Application of Photodynamic Therapy in the
           Skin Metastases Treatment of Breast Cancer

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      Abstract: Abstract The article describes the experience of using photodynamic therapy in the treatment of skin metastases of a patient with breast cancer. The authors note the high effectiveness of this method of treatment in combination with safety. The obtained data allow us to conclude that photodynamic therapy is a very promising method of treating this cohort of patients. Patient K., 69 years old, was diagnosed with cancer of the left breast in October 2015. T2N3M0. Stage IIIC. Complex treatment was carried out: 2 courses of neoadjuvant chemotherapy + radical mastoectomy + remote radiation therapy summation of the focal dose 30gr + 4 courses of adjuvant chemotherapy. In the period up to February 2020, the patient repeatedly received supportive treatment in the palliative care department. Taking into account the volume of metastatic skin lesions, palliative multi-course PDT was recommended. As a result of the treatment, a partial regression of the tumor was obtained. On examination, the scar in the area of PDT is pale pink; the continued growth of the tumor is determined in the form of separate areas of infiltration along the anterior edge of the scar.
      PubDate: 2021-09-28
       
  • Encapsulation of Baicalein in Cinnamon Essential Oil Nanoemulsion for
           Enhanced Anticancer Efficacy Against MDA-MB-231 Cells

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      Abstract: Baicalein-loaded cinnamon essential oil nanoemulsion (BaiCN) was formulated to enhance the solubility and oral bioavailability of the drug, and its potential combined anticancer efficacy with cinnamon oil was evaluated against the MDA-MB-231 breast cancer cell line. The formulation was optimized using full factorial design, and the optimized formulation was characterized for its size distribution, morphology, FTIR analysis, release, and storage stability at 4 °C. The cytotoxicity of developed formulation was assessed via MTT assay on MDA-MB-231 cell line. The average droplet size was found to be 139.05 ± 0.05 nm with a polydispersity index (PDI) value of 0.154 ± 0.029. The zeta potential of BaiCN was −14.35 ± 0.21 mV. Upon storage up to 6 months at 4 °C, there was no change in physical appearance or phase separation. However, a little increase in droplet size and PDI was observed. BaiCN exhibited good in vitro anticancer results against MDA-MB-231. There was about 19-fold and 23-fold enhancements in anticancer activity of BaiCN compared to that of free baicalein after 12 h and 24 h of treatment, respectively. Moreover, the cinnamon oil nanoemulsion without baicalein also showed good cytotoxicity against MDA-MB-231 cells and provided a collaborative effect to baicalein. In conclusion, cinnamon oil nanoemulsion is a promising drug carrier for encapsulating baicalein and enhancing their anticancer effect. Graphical abstract
      PubDate: 2021-09-14
      DOI: 10.1007/s12668-021-00900-y
       
  • Anticancer, Antimicrobial and Hemolytic Assessment of Zinc Oxide
           Nanoparticles Synthesized from Lagerstroemia indica

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      Abstract: Abstract This study evaluated the anticancer, antimicrobial, and hemolytic potential of zinc oxide nanoparticles (ZnO-NPs) synthesized from a novel medicinal plant Lagerstroemia indica. The formation of synthesized ZnO-NPs was confirmed by ultraviolet–visible (UV–Vis) spectroscopy at a peak of 302 nm, and the X-ray diffraction (XRD) analysis confirmed particle size of 19.66 nm. The transmission electron microscopy (TEM) and scanning electron microscope (SEM) with energy dispersive spectroscopy (EDS) micrograph confirmed hexagonal shapes with purity of ZnO. Fourier transform infrared (FTIR) analysis confirmed the presence of various functional groups. The minimum inhibitory concentration (MIC) of ZnO against the four bacteria Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae was found to be 88 µg/ml, 52 µg/ml, 79 µg/ml, and 72 µg/ml, respectively, that completely inhibited the bacterial growth. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) test showed significant cytotoxic potential against MCF-7 and HeLa cells with the IC50 concentrations at 36.28 μg/ml and 30.10 μg/ml, respectively. ZnO-NPs showed subsequent reduction in mitochondrial membrane potential (MMP) and increased level of reactive oxygen species (ROS). The acridine orange/ethidium bromide (AO/EB) staining showed more number of early apoptotic and late apoptotic cells as compared to the standard drug, Camptothecin. Through real-time quantitative polymerase chain reaction (RT-qPCR), the level of Caspase 3 and p53 was upregulated, and these NPs do not have any hemolytic potential on human RBCs in both MCF-7 and HeLa cell lines. Thus, the synthesized ZnO-NPs from the medicinal plant L. indica could be used as an anticancer agent after further in vivo trials.
      PubDate: 2021-09-06
      DOI: 10.1007/s12668-021-00889-4
       
  • Investigation of Volatile Organic Compounds and Benzo[a]pyrene Contents in
           the Aerosols of Cigarettes and IQOS Tobacco Heating System Using
           High-Performance Gas Chromatography/Mass Spectrometry

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      Abstract: Abstract The aim of the research was to compare the content of tobacco smoke obtained from five cigarette brands, 3R4F reference cigarette, and emission derived from IQOS tobacco heating system (Technical regulations of Customs Union “Technical regulations for tobacco products” (TP TC 035/2014) http://www.eurasiancommission.org/ru/act/texnreg/deptexreg/tr/Pages/tabac.aspx Accessed 5 August 2021). Constituents of the IQOS tobacco heating system stick aerosol, mainstream smoke of five commercial cigarettes, and 3R4F reference cigarette smoke were tested. The list of toxicants that are relevant to human health risks and appear on lists of priority toxicants in cigarette smoke was selected. Nicotine, carbon monoxide, 1,3-butadiene, benzene, and benzo[a]pyrene contents were measured using gas chromatography/mass spectrometry methods. Most of the analyzed compounds were detected in the IQOS mainstream aerosol at a significantly lower level than in smoke of the 3R4F reference cigarette and commercial cigarettes. The nicotine content decreased in IQOS mainstream aerosol by 33.7–40.3% compared to 3R4F reference cigarettes and by 42.7% compared to cigarette brands. The yields per puff were similar to the data published by the PMI tobacco company (Schaller et al. in Regul Toxicol Pharmacol 81:S27-S47, 11) and independent laboratories (Li et al. in Nicotine Tob Res 21:111–118, 12; Mallock et al. in Arch Toxicol 92: 2145, 13). Our results showed that the content of priority toxic compounds indicated in the WHO/FDA and Health Canada lists (carbon monoxide, 1,3-butadiene, benzene, and benzo[a]pyrene) and nicotine was significantly lower in case of IQOS tobacco stick aerosol than in the smoke of the 3R4F reference and commercial cigarettes. So our study represents one of the few independent studies on THS products showing similar data on aerosol emissions to those showed by the tobacco industry.
      PubDate: 2021-09-06
      DOI: 10.1007/s12668-021-00898-3
       
  • Targeting of AKT-Signaling Pathway Potentiates the Anti-cancer Efficacy of
           Doxorubicin in A673 Ewing Sarcoma Cell Line

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      Abstract: Abstract The phosphoinositide 3-kinase (PI3K)/Akt/mTOR signaling pathway plays an important role in the regulation of signal transduction and broad spectrum of biological processes such as cell metabolism, proliferation, apoptosis, autophagy, senescence, and angiogenesis. Given that activation of (PI3K)/Akt/mTOR signaling is documented for a broad spectrum of human malignancies supporting their growth and progression, the components of this pathway are considered prospective molecular targets for anti-cancer therapies. Here, we report the activation of Akt signaling in A673 Ewing’s sarcoma cell line when compared to non-transformed BJ tert fibroblasts. MK2206, a well-known Akt inhibitor, synergistically increases doxorubicin(Dox)-induced cytotoxicity in A673 cells. In particular, inhibition of Akt signaling in A673 tumor cells potentiated Dox-induced apoptosis and inhibited proliferation of tumor cells. Inhibition of Akt signaling in Dox-treated A673 cells was associated with decreased expression of Rad51 recombinase, thereby suggesting unsuccessful homology-mediated repair of DNA damage induced by topoisomerase II inhibitor. This was consistent with decreased levels of DNA damage repair (DDR) proteins (e.g., phosphorylated forms of ATR, BRCA1, Chk1, and Chk2) in tumor cells treated with combination of MK2206 and Dox. Of note, expression of phosphorylated form of gamma-H2AX in A673 cells treated with Dox in presence of MK2206 was increased, thereby revealing unrepaired DNA damage in Akt-inhibited cells. Collectively, pharmacological inhibition of Akt signaling synergistically increases the efficiency of doxorubicin in Ewing sarcoma A673 cell line and might serve as a prospective molecular target in ES to enhance cytotoxic effects of DNA-topoisomerase II inhibitors.
      PubDate: 2021-09-04
      DOI: 10.1007/s12668-021-00901-x
       
  • Resveratrol Loaded Cubic Phase Nanoparticles with Enhanced Oral
           Bioavailability

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      Abstract: Resveratrol (RES), a naturally occurring hydrophobic polyphenolic compound, has shown potential anticancer activity. However, due to low aqueous solubility and extensive first pass metabolism (primarily by cytochrome enzymes), it shows poor oral bioavailability. In the present work, novel RES loaded cubosomes of glycerol monooleate (GMO) and Gelucire 44/14 (GL44) (RES-Cubs) were prepared. RES-Cubs were prepared by emulsion evaporation technique and optimized using 32 factorial design. The optimized RES-Cubs were assessed for particle size, zeta potential, entrapment efficiency, FTIR, TEM, SAXS, in vitro resveratrol release and oral bioavailability. RES-Cubs showed an average particle size of 121.7 ± 2.54 nm with adequate entrapment efficiency of about 82.0 ± 2.35% w/w. The analysis of SAXS profile of RES-Cubs revealed Pn3m crystallographic space group containing diamond cubic phase. In vitro RES release profile of RES-Cubs exhibited markedly sustained release of resveratrol. Furthermore, RES-Cubs demonstrated considerable enhancement in oral bioavailability (ninefold) of resveratrol as compared to RES alone. The developed RES loaded cubosomes bearing cytochrome enzyme inhibitor property can act as promising nanocarrier in the delivery of lipophilic drugs with a drawback of in vivo degradation by cytochrome enzymes. Graphical abstract
      PubDate: 2021-09-03
      DOI: 10.1007/s12668-021-00892-9
       
  • Electromagnetic Hybrid Nano-Blood Pumping via Peristalsis Through an
           

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      Abstract: Abstract This article refers to an investigation of peristaltic transport of hybrid nanoparticle suspended blood through an endoscopic annulus with elastic walls in the existence of blood clotting under electromagnetic forces (EMF). The dual effects of Hall and ion-slip currents are accounted for. The energy equation is formulated invoking internal heat source and viscous-Ohmic dissipation terms. Blood is used as a base fluid, and silver and aluminum oxide nanoparticles are dispersed in order to have a hybrid blood suspension. The impacts of the geometrical shape of nanoparticles are examined. The governing partial differential equations (PDEs) for the proposed flow model are simplified under the assumption of long wavelength and low Reynolds number. The transformed non-linear coupled PDEs are solved analytically by employing the homotopy perturbation method (HPM) with Mathematica computational software. The graphical illustrations are presented to interpret various flow constraints of interest. Outcomes reflect that the Hall and ion slip parameters have diminishing behavior on the blood flow while the opposite fashion prevails on it for increasing Hartmann number. Augmenting Hall and ion slip parameters result in an upsurge in the blood temperature. Expanding the volume fraction of nanoparticles enhances the blood temperature. Hall and ion slip effects are to reduce the wall shear stress (WSS) at the peristaltic wall. The maximum amplitude of the heat transfer coefficient is computed for the brick shape of nanoparticles when compared to the other shapes of nanoparticles. The streamlines are configured with trapping ed bolus phenomena to outline the blood flow pattern in the endoscope. Our model may be pertinent to physiological systems, medical simulation devices, transport phenomena in pharmacology, nano-pharmacological delivery systems, surgical procedures, etc. In endoscopy, a magnetic force field is used in order to detect or treat diseases.
      PubDate: 2021-09-01
      DOI: 10.1007/s12668-021-00853-2
       
  • Effect of Chitosan-Coated Nanostructured Lipid Carrier on Escherichia coli
           Biofilms

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      Abstract: Abstract Antimicrobial delivery systems are useful tools to control biofilm growth on abiotic surfaces such as urinary catheter. The present study examined whether nanostructured lipid carriers coated with chitosan (NLC-chitosan) affected the growth of uropathogenic biofilms of Escherichia coli. NLC-chitosan was prepared using the emulsion and sonication method, and further characterized with respect to particle size, polydispersity index, and zeta potential. After determining the minimum inhibitory and bactericidal concentrations, E. coli biofilms were grown on catheter specimens (following a preliminary study in which E. coli was found to adhere better to the catheter surface than glass slide and plate). At the 48, 72, 96, and 120 h of growth, they were exposed to 0.9% NaCl solution (negative control), 0.12% chlorhexidine solution (positive control), or NLC-chitosan (final chitosan concentration of 0.28%). After 24 h of treatment, the biofilms were collected to analyze their bacterial viability. NLC-chitosan preparation had bimodal particle size distribution with mean size of 292.9 ± 2.5 nm and polydispersity index of 0.24 ± 0.03 and positive zeta potential (+19.1 ± 0.2) indicating the nanoparticle coating by chitosan. Compared with the control groups, NLC-chitosan affected bacterial viability of biofilms at all ages studied (p<0.05). NLC-chitosan can effectively control the growth of young and mature biofilms of uropathogenic E. coli.
      PubDate: 2021-09-01
      DOI: 10.1007/s12668-021-00872-z
       
  • Shape Dependent Antibacterial Activity of Various Forms of ZnO
           Nanostructures

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      Abstract: Abstract The physicochemical properties of nanomaterials depend on their size and shapes which are key factors for various biomedical applications. ZnO nanostructures were prepared with various shapes including nanospheres, nanoplates, and nanopyramids using hydrothermal method. ZnO nanoparticles (NPs) have antibacterial properties against Escherichia coli (E. coli) bacteria, and they have the ability to control or destroy them. Physicochemical properties of the prepared nanostructures were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), ultraviolet-visible absorption spectroscopy (UV-Vis), and photoluminescence spectroscopy (PL). XRD analysis confirmed that formation of the wurtzite phase of zinc oxide NPs and PL results revealed low structural defects of the produced NPs. Antibacterial activity of the produced nanostructures was probed against gram-negative E. coli bacteria. The results of antibacterial experiments exhibited that ZnO nanopyramids prepared at temperature of 70 °C have a more inhibitory effect than nanospheres and nanoplates. These indicate that the antibacterial activity of ZnO NPs depends on the morphology and shape in addition to concentration of the nanomaterial.
      PubDate: 2021-09-01
      DOI: 10.1007/s12668-021-00870-1
       
  • Influence of Hall and Ion-Slip Currents on Peristaltic Transport of
           Magneto-Nanofluid in an Asymmetric Channel

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      Abstract: Abstract Of special concern here is to examine the dual impact of Hall and ion-slip currents on a peristaltic transport of water-based nanofluid in an asymmetric channel under the influence of a strong magnetic field. The heat transfer is simulated in the presence of viscous and Ohmic dissipations. Copper-water nanofluid is considered in this simulation. The governing equations are simplified under long wavelength and small Reynolds number approximations. Closed-form solutions are obtained for stream function, axial velocity, temperature, and axial pressure gradient. The graphical analysis examines the impacts of various influential parameters on axial velocity, temperature, axial pressure gradient, pressure rise, frictional forces, heat transfer coefficient, and streamline structure. The temperature function shows a decaying behavior due to the existence of Hall and ion-slip currents. The incorporation of Hall and ion-slip currents leads to lessening the axial pressure gradient. The trapping phenomena are designed and discussed under significant governing parameters. The entrapped bolus is symmetric about the centerline for the symmetric channel whereas it slightly tends to shift in the reverse direction of the wave propagation for the asymmetric channel. This study is envisioned to shed light on conceivable applications in pharmaceutical, physiological, biological, and technological sciences.
      PubDate: 2021-07-20
      DOI: 10.1007/s12668-021-00881-y
       
  • Hyaluronic Acid/Oxidized К-Carrageenan Electrospun Nanofibers Synthesis
           and Antibacterial Properties

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      Abstract: Abstract The current examination is relating to building up a novel nanofiber wound dressing including hyaluronic acid (HA)/oxidized К-carrageenan (OKC) for biomedical application. Until now, electrospinning of К-carrageenan (КC) has fizzled, because of its high-hydrophilic nature, its shaping gel partiality. To beat this problem, KC is exposed to oxidation, by means of sodium periodate (NaIO4). The ideal conditions are NaIO4 to КC 0.5:1; temperature, 40 °C; time, 3 h; and pH 3. OКC was mixed with HA and polyvinyl alcohol (PVA) for delivering electrospun arrangement, which is at long last manufactured to frame nanofiber, utilizing electrospinning setup. The created nanofiber was evaluated by SEM and FTIR spectroscopy, and measuring antibacterial properties was likewise assessed. SEM pictures uncovered that the mixing proportion 2.5:2.5:5 of HA, OКC, and PVA individually accomplished uniform, normal, and globule-free nano-filaments. The outcomes showed likewise that all nano-filaments have antibacterial properties against Gram-positive and Gram-negative microbes, which is elevated to be utilized effectively in biomedical applications.
      PubDate: 2021-07-06
      DOI: 10.1007/s12668-021-00884-9
       
  • In Vitro Apoptosis Evaluation and Kinetic Modeling onto Cyclodextrin-Based
           

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      Abstract: Abstract Supramolecular carriers as a targeted drug delivery system have a significant role in managing the pharmacokinetics and pharmacodynamics of drugs. Therefore, in this project, we used cyclodextrin (CD) as a host molecule for tamoxifen (TMX) and methotrexate (MTX) to evaluate apoptosis mechanism and statistical patterns of release. The flow cytometry analysis showed that combination therapy by anticancer drugs was successful in apoptosis induction compared to free TMX and MTX. Also, real-time PCR and western blot analyses were performed to measure gene expression of Bak1, Bclx, and caspase-3 in estrogen and folate receptor-positive MCF-7 cell lines. All results confirmed that MNPs containing TMX and MTX can significantly increase Bak1/Bclx ratios plus the activity of caspase-3, while free MTX and free TMX showed no effects on triggering apoptosis after 24 h of exposure. According to results of pharmacokinetic studies onto TMX and MTX release, it is revealed that both models that consist of Sahlin-Peppas and Ritger-Peppas create the good fitting curves more than other statistical patterns at both low and high temperatures (37°C and 42°C). For this reason, activation parameters (ΔH‡, ΔS‡, and ΔG‡) were calculated to estimate the favorable model. The lower energy barrier indicates that the Sahlin-Peppas is the favorable model with both diffusion and relaxation process. Therefore, combination therapy by two anticancer drugs, TMX and MTX, utilizing cyclodextrin-based host–guest supramolecular magnetic nanoparticles (CD-MNPs) provided new results for induction of apoptosis and pharmacokinetic model.
      PubDate: 2021-06-05
      DOI: 10.1007/s12668-021-00877-8
       
 
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