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CHEMISTRY (598 journals)                  1 2 3 | Last

Showing 1 - 200 of 735 Journals sorted alphabetically
2D Materials     Hybrid Journal   (Followers: 8)
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 26)
ACS Catalysis     Full-text available via subscription   (Followers: 32)
ACS Chemical Neuroscience     Full-text available via subscription   (Followers: 17)
ACS Combinatorial Science     Full-text available via subscription   (Followers: 23)
ACS Macro Letters     Full-text available via subscription   (Followers: 23)
ACS Medicinal Chemistry Letters     Full-text available via subscription   (Followers: 39)
ACS Nano     Full-text available via subscription   (Followers: 227)
ACS Photonics     Full-text available via subscription   (Followers: 11)
ACS Synthetic Biology     Full-text available via subscription   (Followers: 21)
Acta Chemica Iasi     Open Access   (Followers: 2)
Acta Chimica Sinica     Full-text available via subscription   (Followers: 1)
Acta Chimica Slovaca     Open Access   (Followers: 1)
Acta Chromatographica     Full-text available via subscription   (Followers: 9)
Acta Facultatis Medicae Naissensis     Open Access  
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 5)
Acta Scientifica Naturalis     Open Access   (Followers: 2)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 5)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 7)
Adsorption Science & Technology     Full-text available via subscription   (Followers: 5)
Advanced Functional Materials     Hybrid Journal   (Followers: 50)
Advanced Science Focus     Free   (Followers: 3)
Advances in Chemical Engineering and Science     Open Access   (Followers: 53)
Advances in Chemical Science     Open Access   (Followers: 13)
Advances in Chemistry     Open Access   (Followers: 14)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Enzyme Research     Open Access   (Followers: 9)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 8)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 15)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8)
Advances in Materials Physics and Chemistry     Open Access   (Followers: 19)
Advances in Nanoparticles     Open Access   (Followers: 14)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15)
Advances in Polymer Science     Hybrid Journal   (Followers: 41)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 19)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Science and Technology     Full-text available via subscription   (Followers: 12)
African Journal of Bacteriology Research     Open Access  
African Journal of Chemical Education     Open Access   (Followers: 2)
African Journal of Pure and Applied Chemistry     Open Access   (Followers: 7)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 67)
American Journal of Biochemistry and Molecular Biology     Open Access   (Followers: 14)
American Journal of Chemistry     Open Access   (Followers: 26)
American Journal of Plant Physiology     Open Access   (Followers: 13)
American Mineralogist     Hybrid Journal   (Followers: 13)
Analyst     Full-text available via subscription   (Followers: 38)
Angewandte Chemie     Hybrid Journal   (Followers: 158)
Angewandte Chemie International Edition     Hybrid Journal   (Followers: 208)
Annales UMCS, Chemia     Open Access   (Followers: 1)
Annals of Clinical Chemistry and Laboratory Medicine     Open Access   (Followers: 1)
Annual Reports in Computational Chemistry     Full-text available via subscription   (Followers: 3)
Annual Reports Section A (Inorganic Chemistry)     Full-text available via subscription   (Followers: 3)
Annual Reports Section B (Organic Chemistry)     Full-text available via subscription   (Followers: 8)
Annual Review of Chemical and Biomolecular Engineering     Full-text available via subscription   (Followers: 12)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 14)
Anti-Infective Agents     Hybrid Journal   (Followers: 3)
Antiviral Chemistry and Chemotherapy     Hybrid Journal  
Applied Organometallic Chemistry     Hybrid Journal   (Followers: 7)
Applied Spectroscopy     Full-text available via subscription   (Followers: 23)
Applied Surface Science     Hybrid Journal   (Followers: 28)
Arabian Journal of Chemistry     Open Access   (Followers: 6)
ARKIVOC     Open Access   (Followers: 2)
Asian Journal of Biochemistry     Open Access   (Followers: 1)
Atomization and Sprays     Full-text available via subscription   (Followers: 3)
Australian Journal of Chemistry     Hybrid Journal   (Followers: 7)
Autophagy     Hybrid Journal   (Followers: 2)
Avances en Quimica     Open Access   (Followers: 1)
Biochemical Pharmacology     Hybrid Journal   (Followers: 10)
Biochemistry     Full-text available via subscription   (Followers: 283)
Biochemistry Insights     Open Access   (Followers: 5)
Biochemistry Research International     Open Access   (Followers: 6)
BioChip Journal     Hybrid Journal  
Bioinorganic Chemistry and Applications     Open Access   (Followers: 9)
Bioinspired Materials     Open Access   (Followers: 5)
Biointerface Research in Applied Chemistry     Open Access   (Followers: 2)
Biointerphases     Open Access   (Followers: 1)
Biology, Medicine, & Natural Product Chemistry     Open Access   (Followers: 1)
Biomacromolecules     Full-text available via subscription   (Followers: 19)
Biomass Conversion and Biorefinery     Partially Free   (Followers: 10)
Biomedical Chromatography     Hybrid Journal   (Followers: 6)
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 3)
BioNanoScience     Partially Free   (Followers: 4)
Bioorganic & Medicinal Chemistry     Hybrid Journal   (Followers: 108)
Bioorganic & Medicinal Chemistry Letters     Hybrid Journal   (Followers: 93)
Bioorganic Chemistry     Hybrid Journal   (Followers: 10)
Biopolymers     Hybrid Journal   (Followers: 18)
Biosensors     Open Access   (Followers: 2)
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 1)
Bitácora Digital     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 2)
Bulletin of the Chemical Society of Japan     Full-text available via subscription   (Followers: 24)
Bulletin of the Korean Chemical Society     Hybrid Journal   (Followers: 1)
C - Journal of Carbon Research     Open Access   (Followers: 3)
Cakra Kimia (Indonesian E-Journal of Applied Chemistry)     Open Access  
Canadian Association of Radiologists Journal     Full-text available via subscription   (Followers: 2)
Canadian Journal of Chemistry     Hybrid Journal   (Followers: 10)
Canadian Mineralogist     Full-text available via subscription   (Followers: 3)
Carbohydrate Research     Hybrid Journal   (Followers: 26)
Carbon     Hybrid Journal   (Followers: 67)
Catalysis for Sustainable Energy     Open Access   (Followers: 6)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 8)
Catalysis Science and Technology     Free   (Followers: 6)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 3)
Catalysts     Open Access   (Followers: 7)
Cellulose     Hybrid Journal   (Followers: 7)
Cereal Chemistry     Full-text available via subscription   (Followers: 4)
ChemBioEng Reviews     Full-text available via subscription   (Followers: 1)
ChemCatChem     Hybrid Journal   (Followers: 8)
Chemical and Engineering News     Free   (Followers: 12)
Chemical Bulletin of Kazakh National University     Open Access  
Chemical Communications     Full-text available via subscription   (Followers: 70)
Chemical Engineering Research and Design     Hybrid Journal   (Followers: 23)
Chemical Research in Chinese Universities     Hybrid Journal   (Followers: 3)
Chemical Research in Toxicology     Full-text available via subscription   (Followers: 19)
Chemical Reviews     Full-text available via subscription   (Followers: 170)
Chemical Science     Open Access   (Followers: 21)
Chemical Technology     Open Access   (Followers: 16)
Chemical Vapor Deposition     Hybrid Journal   (Followers: 5)
Chemical Week     Full-text available via subscription   (Followers: 8)
Chemie in Unserer Zeit     Hybrid Journal   (Followers: 55)
Chemie-Ingenieur-Technik (Cit)     Hybrid Journal   (Followers: 25)
ChemInform     Hybrid Journal   (Followers: 8)
Chemistry & Biodiversity     Hybrid Journal   (Followers: 6)
Chemistry & Biology     Full-text available via subscription   (Followers: 30)
Chemistry & Industry     Hybrid Journal   (Followers: 5)
Chemistry - A European Journal     Hybrid Journal   (Followers: 144)
Chemistry - An Asian Journal     Hybrid Journal   (Followers: 15)
Chemistry and Materials Research     Open Access   (Followers: 18)
Chemistry Central Journal     Open Access   (Followers: 4)
Chemistry Education Research and Practice     Free   (Followers: 5)
Chemistry in Education     Open Access   (Followers: 9)
Chemistry International     Hybrid Journal   (Followers: 2)
Chemistry Letters     Full-text available via subscription   (Followers: 45)
Chemistry of Materials     Full-text available via subscription   (Followers: 226)
Chemistry of Natural Compounds     Hybrid Journal   (Followers: 9)
Chemistry World     Full-text available via subscription   (Followers: 22)
Chemistry-Didactics-Ecology-Metrology     Open Access  
ChemistryOpen     Open Access   (Followers: 2)
Chemkon - Chemie Konkret, Forum Fuer Unterricht Und Didaktik     Hybrid Journal  
Chemoecology     Hybrid Journal   (Followers: 2)
Chemometrics and Intelligent Laboratory Systems     Hybrid Journal   (Followers: 15)
Chemosensors     Open Access  
ChemPhysChem     Hybrid Journal   (Followers: 9)
ChemPlusChem     Hybrid Journal   (Followers: 2)
ChemTexts     Hybrid Journal  
CHIMIA International Journal for Chemistry     Full-text available via subscription   (Followers: 2)
Chinese Journal of Chemistry     Hybrid Journal   (Followers: 6)
Chinese Journal of Polymer Science     Hybrid Journal   (Followers: 10)
Chromatographia     Hybrid Journal   (Followers: 24)
Chromatography Research International     Open Access   (Followers: 7)
Clay Minerals     Full-text available via subscription   (Followers: 9)
Cogent Chemistry     Open Access  
Colloid and Interface Science Communications     Open Access  
Colloid and Polymer Science     Hybrid Journal   (Followers: 10)
Colloids and Surfaces B: Biointerfaces     Hybrid Journal   (Followers: 8)
Combinatorial Chemistry & High Throughput Screening     Hybrid Journal   (Followers: 3)
Combustion Science and Technology     Hybrid Journal   (Followers: 18)
Comments on Inorganic Chemistry: A Journal of Critical Discussion of the Current Literature     Hybrid Journal   (Followers: 2)
Composite Interfaces     Hybrid Journal   (Followers: 6)
Comprehensive Chemical Kinetics     Full-text available via subscription   (Followers: 2)
Comptes Rendus Chimie     Full-text available via subscription  
Comptes Rendus Physique     Full-text available via subscription   (Followers: 1)
Computational and Theoretical Chemistry     Hybrid Journal   (Followers: 9)
Computational Biology and Chemistry     Hybrid Journal   (Followers: 12)
Computational Chemistry     Open Access   (Followers: 2)
Computers & Chemical Engineering     Hybrid Journal   (Followers: 9)
Coordination Chemistry Reviews     Full-text available via subscription   (Followers: 2)
Copernican Letters     Open Access  
Critical Reviews in Biochemistry and Molecular Biology     Hybrid Journal   (Followers: 5)
Crystal Structure Theory and Applications     Open Access   (Followers: 3)
CrystEngComm     Full-text available via subscription   (Followers: 11)
Current Catalysis     Hybrid Journal   (Followers: 2)
Current Metabolomics     Hybrid Journal   (Followers: 5)
Current Opinion in Colloid & Interface Science     Hybrid Journal   (Followers: 9)
Current Research in Chemistry     Open Access   (Followers: 8)
Current Science     Open Access   (Followers: 56)
Dalton Transactions     Full-text available via subscription   (Followers: 20)
Detection     Open Access   (Followers: 2)
Developments in Geochemistry     Full-text available via subscription   (Followers: 2)
Diamond and Related Materials     Hybrid Journal   (Followers: 12)
Dislocations in Solids     Full-text available via subscription  
Doklady Chemistry     Hybrid Journal  
Drying Technology: An International Journal     Hybrid Journal   (Followers: 4)
Eclética Química     Open Access   (Followers: 1)
Ecological Chemistry and Engineering S     Open Access   (Followers: 4)
Ecotoxicology and Environmental Contamination     Open Access  
Educación Química     Open Access   (Followers: 1)
Education for Chemical Engineers     Hybrid Journal   (Followers: 5)
EJNMMI Radiopharmacy and Chemistry     Open Access  
Elements     Full-text available via subscription   (Followers: 2)
Environmental Chemistry     Hybrid Journal   (Followers: 9)
Environmental Chemistry Letters     Hybrid Journal   (Followers: 4)
Environmental Science & Technology Letters     Full-text available via subscription   (Followers: 5)

        1 2 3 | Last

Journal Cover BioNanoScience
  [SJR: 0.428]   [H-I: 10]   [4 followers]  Follow
   Partially Free Journal Partially Free Journal
   ISSN (Print) 2191-1630 - ISSN (Online) 2191-1649
   Published by Springer-Verlag Homepage  [2355 journals]
  • In Vitro Recombinant Expression of Novel Protective Protein Highly
           Accumulated in Dry State in an Anhydrobiotic Insect
    • Authors: Hagiwara-Komoda Yuka; Oleg Gusev; Elena Shagimardanova; Takahiro Kikawada
      Pages: 263 - 264
      Abstract: Recent intensive studies showed that ability of several groups of organisms to withstand complete desiccation (anhydrobiosis state) is largely based on the activity of several groups of key proteins, including representatives of intrinsically disordered ones. In the largest known anhydrobiotic animal, the sleeping chironomid, both proteomic and genome-wide/targeted mRNA expression analysis suggest that several groups of the novel proteins greatly contribute to the formation of the molecular shield. Among them, 114 aa-long protein, dryporin. Being one of the most abundant in the desiccated larvae on protein level and showing one of the highest expression on mRNA level, this protein shows lack of the obvious homology with other known proteins. In this study, we successfully produced recombinant dryporin protein using BY-2 cell free lysate and showed the evidence of post-translational modification of the protein in the anhydrobiotic larvae.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0356-0
      Issue No: Vol. 7, No. 2 (2017)
  • Myogenic Trigger Zone of Trapezius Muscle Increases the Tone of the Middle
           Cerebral Artery
    • Authors: Oleg Esin; Radiy Esin; Ilshat Khairullin
      Pages: 300 - 301
      Abstract: A myogenic trigger zone (MTZ) has been shown to affect the tone of the surface arteries of the head and lower limbs. However, it remains largely unknown whether the tone of the intracranial arteries is regulated by MTZ. The aim of the present study was to investigate the effect of MTZ in trapezius muscle on the tone of the middle cerebral artery. Using ultrasound measurements of the peak velocity of blood flow and the Lindegaard index (LI), we found that the presence of an active MTZ in a trapezius muscle was per se associated with an increased LI values and that pressure stimulation of the MTZ further increases LI. When MTZ was eliminated by means of manual therapy, the indices of blood flow and LI returned to normal values. We conclude that the reflex spasm of the middle cerebral artery can occur in the presence of an active MTZ-TM and that this phenomenon contributes to the pathogenesis and the clinical symptoms associated with the cervicogenic and tension headaches.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0344-4
      Issue No: Vol. 7, No. 2 (2017)
  • Population Dynamics of MafA-Positive Cells During Ontogeny of Human
    • Authors: Maxim Kaligin; Aleksandra Pliushkina; Angelina Titova; Marina Titova; Anisa Gumerova; Andrei Kiassov
      Pages: 352 - 359
      Abstract: Diverse transcription factors influencing cell differentiation are often chosen as markers of β cell progenitors. One of these transcription factors is MafA, which according to data in literature activates the expression of insulin gene in β cells. Other data support the hypothesis that MafA is required solely for the regulation of insulin secretion by β cells of adult islets and is not involved in the development of islet cells. In this paper, we study the role of MafA through both examination of human pancreas ontogeny and comparison of these data with dynamic changes in the population of insulin-positive and glucagon-positive cells. The aim of this research was the immunohistochemical analysis of MafA, insulin, and glucagon expression during human pancreas ontogeny. The research was conducted on whole embryos and isolated human fetal organs, obtained as a result of either miscarriage or legal medical abortion with voluntary consent of patients, and also on autopsy material from infant and adult human pancreas. As a result of this study, it was found that, during the ontogeny of human pancreas, the first MafA-positive cells appear in the islets at 12.5 weeks of gestation, that is, later than both insulin-positive cells (11.5 weeks of gestation) and glucagon-positive cells (8.5 weeks of gestation). No MafA-positive cells were found in the epithelium of pancreatic ducts. The number of MafA-positive cells in the islets increases during pancreatic organogenesis. The results of our research do not allow us to regard MafA as a marker of undifferentiated progenitors of islet cells. Based on this, we believe that the results obtained in this study are a supplementary contribution to the hypothesis that relates MafA to the markers of adult β cells.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0369-8
      Issue No: Vol. 7, No. 2 (2017)
  • The Nature of Regulatory Autoantibody Changes Among Pregnant Women with
           Intrauterine Growth Restriction
    • Authors: R. S. Zamaleeva; N. A. Cherepanova; A. V. Frizina; N. Y. Chistiakova
      Pages: 373 - 375
      Abstract: Anenzyme-linked immunosorbent assay known as ELI-TEST was applied in 388 pregnant women in the gestational complication risk group who were 11– 4 weeks into pregnancy for the purpose of determining the serum content of Ig G class/that bind to double-stranded DNA, β2-glycoprotein I (β2 GP), total phospholipids (TFL), HCG vasculopathy markers (ANCA), collagen (Coll), PAPP-A, and insulin (Ins). After standardizing groups, 80 pregnant women with intrauterine growth restriction (IUGR) were selected for analysis. Characteristic changes in the levels of autoantibodies accompanying IUGR of varying severity were identified which not only gives a more accurate understanding of the pathogenesis of the disease but also enables one to define IUGR risk groups in the early stages of pregnancy.
      PubDate: 2017-06-01
      DOI: 10.1007/s12668-016-0365-z
      Issue No: Vol. 7, No. 2 (2017)
  • Regulatory Profile Changes of Lymphocytes and Peripheral Blood Monocytes
           in Children with Candidiasis Associated with Chronic Somatic Diseases
    • Authors: Elena V. Agafonova; Farida F. Rizvanova; Ayzada E. Kadyrova; Levon Abrahamyan
      Abstract: In this paper, we report results of the study of immune parameters with the assessment of regulatory and effector subpopulations of lymphocytes and monocytes with candidiasis in children with chronic somatic diseases (secondary pyelonephritis and obstructive diseases of the upper gastrointestinal tract). Candidiasis was diagnosed by the rising level of circulating Candida albicans mannan antigen and culture mycological research. It was found that the persistence of fungi is associated with differentiated regulatory changes in the structure of subpopulations of lymphocytes and monocytes with preferential increase of immunosuppressive cells (CD4+CD25+hi, CD3+CD16/56+, CD3−CD8+, CD3+4−8−) amid reduction of effector subpopulations of lymphocytes and antigen presenting cells associated with Th1 immune response profile.
      PubDate: 2017-07-22
      DOI: 10.1007/s12668-017-0430-2
  • Maghemite Nanorods and Nanospheres: Synthesis and Comparative Physical and
           Biological Properties
    • Authors: A. Yousefi; S.A. Seyyed Ebrahimi; A. Seyfoori; H. Mahmoodzadeh Hosseini
      Abstract: Hyperthermia treatment of different cancers based on magnetic nanoparticles has gained significant attention in recent years. In this work, biocompatible maghemite (γ-Fe2O3) nanorods were synthesized by dehydroxylation of lepidocrocite (γ-FeOOH) nanorods, using hydrolysis of ferrous salts in the presence of urea followed by calcination at 300 °C for 3 h. Maghemite nanospheres were also synthesized by oxidation of co-precipitated magnetite (Fe3O4) nanoparticles, followed by heat treatment at 250 °C for 3 h. The samples were analyzed by X-ray diffraction, vibrating sample magnetometry, and field emission scanning electron microscopy techniques. Cell viability of nanorods and nanospheres before and after applying a magnetic field was studied by MTT assay on G292 cell lines as a candidate of osteosarcoma 2D-cultured model. The heating capacity of the rod-like and spherical magnetic nanoparticles (MNP) was evaluated under a magnetic field using a solid state induction heating equipment. Moreover, the minimal inhibitory concentration (MIC) antibacterial activity of magnetic nanorods and nanospheres was investigated. The results showed that cell proliferation gradually increased in the presence of both maghemite nanorods and nanospheres compared to the control sample. However, cell viability decreased after applying hyperthermia treatment as indicative of cell apoptosis. Quantification of antibacterial properties also showed the MIC behavior of both nanoparticles at a concentration of 0.078 mg/ml.
      PubDate: 2017-07-21
      DOI: 10.1007/s12668-017-0431-1
  • Development of Approaches to the Study of the Interaction of Biologically
           Active Thioterpenoids with Model Membranes
    • Authors: Liliya E. Nikitina; Sergei V. Kiselev; Andrei V. Bodrov; Valeriya A. Startseva; Nadezhda P. Artemova; Vladimir V. Klochkov; Leisan F. Galiullina; Oksana V. Aganova; Aliya V. Khaliullina; Olga A. Lodochnikova; Zulfiya R. Azizova; Adel A. Rakhmatullina
      Abstract: It was shown that the synthesized camphene sulfone, in contrast to acetylsalicylic acid and clopidogrel, completely inhibits the activation of platelets induced by adrenaline and arachidonic acid, and reduces the influence of ADP, collagen, and ristocetin. Detailed NMR studies and molecular dynamics simulations using model SDS membranes indicated that the sulfone is embedded by its bicyclic part inside the SDS micelle, whereas -SO2(CH2)2OH fragment of sulfone is located on the outer part of the micelle and accessible for solvent. It was ascertained that hemocoagulant activity of sulfone is caused by its capability of inhibition of platelet activation and suppression of catalytic activity of phospholipid surface participating in formation of coagulation complexes of clotting factors.
      PubDate: 2017-07-19
      DOI: 10.1007/s12668-017-0432-0
  • Effect of Co-incubation with Mesenchymal Stromal Cells in Cultural Medium
           on Structure and Mechanical Properties of Polylactide-Based Scaffolds
    • Authors: Kirill Niaza; Fedor Senatov; Natalia Anisimova; Mikhail Kiselevskiy; Sergey Kaloshkin
      Abstract: In present work, the influence of cultural medium on structure and properties of polymer-based scaffolds was studied. Polylactide (PLA) was used as the polymer matrix and micro- and nanoparticles of hydroxyapatite were used as the filler. Extrusion was used to obtain the composites. Porous scaffolds were 3D printed. Cultural medium RPMI-1640 was used as the medium for incubation. Compression tests were used to study mechanical properties before and after incubation. Differential scanning calorimetry was used to study influence of hydrolysis on thermal properties of porous scaffolds. Scaffolds were colonized by mesenchymal stromal cells (MSCs). Microstructure was studied by optical microscopy after colonization. Decrease of mechanical properties was observed after incubation. In vitro test showed cytoconductivity of porous scaffolds.
      PubDate: 2017-07-11
      DOI: 10.1007/s12668-017-0429-8
  • Development of Novel Doxorubicin Loaded Biodegradable Polymeric Nanofibers
           as the Anticancer Drug Delivery Systems
    • Authors: Mohsen Bakhtiari; Roya Salehi; Abolfazl Akbarzadeh; Soodabeh Davaran
      Abstract: Through the present research, for the first time, doxorubicin hydrochloride (DOX)-loaded poly (ε-caprolactone)-poly (ethylene glycol)-poly (ε-caprolactone) (PCL-PEG-PCL, PCEC) nanofibers were obtained by blending electrospinning method. The physicochemical characteristics of the DOX/PCEC nanofibers were fully evaluated. Nanofibers had homogeneous morphology with mean diameters ranging from 80 to 300 nm. The drug releasing behavior showed the faster release rate by increasing the drug content in nanofibers. The in vitro release profile and release kinetics from the DOX/PCEC nanofibers confirmed that the release profile followed Korsmeyer–Peppas model suggesting a Fickian diffusion as a major drug release mechanism.
      PubDate: 2017-07-10
      DOI: 10.1007/s12668-017-0421-3
  • Green Synthesis of Different Shapes of Silver Nanostructures and
           Evaluation of Their Antibacterial and Cytotoxic Activity
    • Authors: Fatemeh Feiz Soleimani; Tayebeh Saleh; Seyed Abbas Shojaosadati; Reza Poursalehi
      Abstract: Silver nanoparticles (NPs) have been demonstrated as a promising antibacterial candidate to fight against resistant pathogens. In this study, different shapes of silver nanostructures (i.e., sphere, rod, and cube) were synthesized by green methods. Morphology, size, and crystalline structure of the produced structures were characterized by UV–visible spectroscopy, scanning electron microscopy (SEM), and X-ray diffraction (XRD). For evaluation of antibacterial activity of silver nanostructures with various shapes, measurement of minimum inhibitory concentrations (MICs) was carried out against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria. The results showed that the concentration of silver nanostructures that prevents bacteria growth is different for each shape, the cubic and rod shape (with sharp edge and vertex) in lower concentrations being more effective than spherical nanoparticles. MTT assay to assess the toxicity of silver nanoparticles showed a concentration and shape-dependent decrease in cell viability in cancer human cells (MCF-7), signifying shape- and dose-dependent toxicity. In addition, the interaction of different nanostructures with serum albumin was evaluated. According to these results, AgNPs with sharper geometry resulted in protein degradation and higher toxicity as compared with smooth or spherical geometries. The results showed that the geometry of silver nanostructures can have quite a significant role in the definition of biological and antibacterial efficacy of NPs, which has significant implications in the design of NPs for various antibacterial applications and will require more consideration in the future.
      PubDate: 2017-07-06
      DOI: 10.1007/s12668-017-0423-1
  • Nanostructured Stable Floating М-Mono- and Bilayers and Langmuir-Schaefer
           Films of 5,10,15-Triphenylcorrole
    • Authors: Larissa A. Maiorova; Thao T. Vu; Olga A. Gromova; Konstantin S. Nikitin; Oskar I. Koifman
      Abstract: 5,10,15-Triphenylcorrole is a tetrapyrrolic macrocyclic compound similar to B12 vitamin, with pyrrole-pyrrole direct coupling and a carbon skeleton. Stable floating nanostructured mono-, bi-, and tetralayers of the compound were prepared. The main characteristics of the structure, properties, and formation conditions of the layers were determined. A model of monolayers consisting of nanoaggregates was built. The triphenylcorrole produces nanostructured face-on and edge-on monolayers. Stable bilayers and tetralayers form at high values of the initial surface coverage, featuring a constant degree of surface coverage by 3D nanoaggregates at the initial point of the stable state (75%). The layers with bilayered 3D nanostructures demonstrate very high stability. Their size (8 nm) and the number of molecules in them (109) are independent of the initial degree of surface coverage. For the first time, a model of floating bilayers of a macroheterocyclic compound was constructed. Langmuir-Schaeffer films of the corrole were prepared from nanostructured floating polylayers produced on the water surface and then were studied spectrally.
      PubDate: 2017-07-01
      DOI: 10.1007/s12668-017-0424-0
  • Improvement of Nociceptive Spike Clusterization with Shape Approximation
    • Authors: O Gafurov; A Zakharov; K Koroleva; R Giniatullin
      Abstract: Cluster spike analysis is widely used for studies of neuronal activity when electrical signals are sorted out and grouped according to the different shapes. We recently applied this method to sort out the nociceptive spikes in the trigeminal nerve implicated in generation of migraine pain. However, the electrical noise leading to less accuracy of calculated spike parameters often hinder the correct sorting of nerve signals. In this study, in order to improve the accuracy of calculations, we explored the prior approximation of spike shapes before applying clusterization. The prior fitting of spike shapes allowed us to extract signal parameters much more precisely and detect the strongly increased number of spike clusters which is close to the expected number of fibers in the trigeminal nerve. Prior approximation improved cluster analysis outcomes and, importantly, revealed new clusters that demonstrated the different functional properties, suggesting that their function was previously hidden within the multiple firing.
      PubDate: 2017-06-27
      DOI: 10.1007/s12668-017-0428-9
  • Synthesis, Characterization and Biocompatibility Studies of Gold
           Nanoparticles from Zingiber officinal
    • Authors: R. L. Babu; Shankar Charanya; Santhosh K. Biradar; Virupaxi Goornavar; Robert Jeffers; Tejaswini Ronurpraful; Prathima T. Prabhu; Arthur Bowman; Joseph C. Hall; Govindarajan T. Ramesh
      Abstract: Synthesis of nanomaterials through eco-friendly (green) approaches has attracted much attention due to the widespread biomedical application and environmental issues. The present study describes the green synthesis of gold nanoparticles (GNPs) using rhizome suspension of ginger (Zingiber officinale). The formation of GNPs was visually observed in a sample by color change from colorless to purple; further, the green synthesis process was optimized for improved production of GNPs with the suspension to chloroauric acid ratio (1:10). The synthesized GNPs were characterized by FESEM, EDX, and TEM. Ginger-based GNP synthesis gave particles of >20 nm in size. The GNPs were largely found to be spherical in shape and stable at room temperature. A live/dead cell viability assay conducted on lung epithelial cells revealed the safe nature of GNP materials up to 25 μg/ml. These results were correlated by MTT assay. It is also observed that there was no significant elevation in reactive oxygen species (ROS) level in GNP-treated lung epithelial cells (BEAS-2B). Biocompatibility studies of GNPs also revealed the negligible cytotoxicity and validate the safe nature, and no induction of oxidative stress. Collectively, these observations suggest the involvement of phytochemicals from the ginger. Future manipulation of these GNPs offers commercial benefits, particularly for biomedical applications like diagnostics and therapeutics.
      PubDate: 2017-06-23
      DOI: 10.1007/s12668-017-0427-x
  • Toxicity and Applications of Internalised Magnetite Nanoparticles Within
           Live Paramecium caudatum Cells
    • Authors: Richard Mayne; James Whiting; Andrew Adamatzky
      Abstract: The nanotechnology revolution has allowed us to speculate on the possibility of hybridising nanoscale materials with live substrates, yet significant doubt still remains pertaining to the effects of nanomaterials on biological matter. In this investigation, we cultivate the ciliated protistic pond-dwelling microorganism Paramecium caudatum in the presence of excessive quantities of magnetite nanoparticles in order to deduce potential beneficial applications for this technique, as well as observe any deleterious effects on the organisms’ health. Our findings indicate that this variety of nanoparticle is well-tolerated by P. caudatum cells, who were observed to consume them in quantities exceeding 5–12% of their body volume: cultivation in the presence of magnetite nanoparticles does not alter P. caudatum cell volume, swimming speed, growth rate or peak colony density and cultures may persist in nanoparticle-contaminated media for many weeks. We demonstrate that P. caudatum cells ingest starch-coated magnetite nanoparticles which facilitates their being magnetically immobilised whilst maintaining apparently normal ciliary dynamics, thus demonstrating that nanoparticle biohybridisation is a viable alternative to conventional forms of ciliate quieting. Ingested magnetite nanoparticle deposits appear to aggregate, suggesting that (a) the process of being internalised concentrates and may therefore detoxify (i.e. render less reactive) nanomaterial suspensions in aquatic environments, and (b) P. caudatum is a candidate organism for programmable nanomaterial manipulation and delivery.
      PubDate: 2017-06-22
      DOI: 10.1007/s12668-017-0425-z
  • Soxhlet Extraction of Neem Pigment to Synthesize Iron Oxide Nanoparticles
           and Its Catalytic and Adsorption Activity for Methylene Blue Removal
    • Authors: Priyabrata Pal; Salma S. Syed; Fawzi Banat
      Abstract: Green synthesis of iron oxide nanoparticles is gaining importance recently due to its cost-effectivity and ecofriendly treatment technique. The aim of the present study is to concentrate neem (Azadirachta indica) leaf pigment using Soxhlet extraction and to synthesize iron oxide nanoparticles and to check its efficacy in degrading methylene blue dye in aqueous solution. Characterization of the synthesized iron oxide nanoparticles is carried out using X-ray diffraction (XRD), Fourier Transform Infrared (FTIR) spectroscopy, Scanning Electron Microscopy (SEM) equipped with Energy Dispersive X-ray (EDX) spectroscopy, Transmission Electron Microscopy (TEM), and Vibrating Sample Magnetometer (VSM) analysis. The characterization results confirm the formation of iron oxide (α-Fe2O3) nanoparticles. Obtained nanoparticles were evaluated for degradation and adsorption of methylene blue (MB) dye. It enhanced the degradation of methylene blue dye to 95.93% in the presence of 0.1 (N) sodium hydroxide solution (82.69% in the absence of α-Fe2O3). The maximum uptake capacity of MB was increased from 64.1 to 99.0 mg/g using native calcium alginate hydrogel and calcium alginate impregnated with produced iron oxide nanoparticle composite hydrogel, respectively. Thus, extraction of pigment from neem leaves and synthesized iron oxide nanoparticles showed satisfactory results.
      PubDate: 2017-06-21
      DOI: 10.1007/s12668-017-0420-4
  • Complicated Conformational Exchange of New Pyridoxine Derivative. Dynamic
           13 C NMR Characterization
    • Authors: I. Z. Rakhmatullin; L. F. Galiullina; F. K. Karataeva; Vladimir V. Klochkov
      Abstract: New pyridoxine derivative with multiple chemical exchanges was studied by 13C (at 298 K, 188 K) and 2D NMR (1H-13C HSQC, 1H-13C HMBC) spectroscopy in acetone-d6 solution. Complete 13C NMR data (table with chemical shifts at different temperatures) is presented. Intramolecular mobility of the molecule was analyzed based on the results of 13C NMR experiments in combination with the data obtained from previous study of this compound by dynamic 1H NMR spectroscopy.
      PubDate: 2017-06-21
      DOI: 10.1007/s12668-017-0426-y
  • Surface Modification of PLLA Electrospun Nanofiber Materials for
           Biomedical Applications
    • Authors: S. I. Goreninskii; K. S. Stankevich; E. N. Bolbasov; N. V. Danilenko; V. D. Filimonov; S. I. Tverdokhlebov
      Abstract: Three dimensional nanofiber materials made of poly-L-lactic acid (PLLA) and produced by electrospinning are commonly used in regenerative medicine and as a base for drug delivery systems. Surface modification of such materials allows manipulating their chemical, physical, and biological properties. Previously, our group reported a number of modification strategies for thin PLLA films, based on the “solvent/non-solvent” technique. Most biologically active agents may not be adsorbed on the surface of PLLA. Proposed treatment allows partially dissolving the polymer surface in order to adsorb biologically active molecules or linkers. The aim of this work was to investigate the influence of solvent/non-solvent mixture composition on the morphology and crystal structure of the electrospun PLLA scaffolds and to select the solvent system for further scaffolds modification in order to impart them biological activity. PLLA scaffolds were treated with mixtures of toluene and ethanol in different compositions. By means of scanning electron microscopy, it was shown that solvent/non-solvent treatment had no critical effect on the morphology of the scaffolds. The results of X-ray diffraction analysis revealed that treatment of the scaffolds with investigated solvent systems did not lead to the formation of the additional phases and the size of the polymer crystallites as well. Thus, selected solvent system will be used for modification of the PLLA electrospun nanofiber material for biomedical application.
      PubDate: 2017-06-19
      DOI: 10.1007/s12668-017-0422-2
  • The Influence of Silicon Oxide Nanoparticles on Morphometric Parameters of
           Monocotyledons and Dicotyledons in Soil and Climatic Conditions of Western
           Siberia, as well as on Microbiological Soil Properties
    • Authors: Natalya Tereshchenko; Olga Zmeeva; Boris Makarov; Aleksandra Kravets; Valeryi Svetlichny; Ivan Lapin; Albina Zotikova; Lydmila Petrova; Tatyana Yunusova
      Abstract: Using a field small-plot experiment, the influence of pre-sowing seed treatment of monocotyledons and dicotyledons, namely hulless oat (Avena sativa L.) and lucerne (Medicago sativa L. subsp. varia (Martyn) Arcang.), with suspensions of silicon oxide (SiO2) nanoparticles in different concentrations on morphometric parameters and microbial cenosis of their rhizosphere was studied. It has been found that spraying of seeds with 3 × 10−5 and 3 × 10−4% suspensions of SiO2 nanoparticles accelerates the growth, and development of oat and lucerne increases the content of photosynthetic pigments in leaves and contributes to 30–40% decrease in height of an oat straw and size reduction of internodes, while increasing the specific weight of a plant by 26–38%. These findings demonstrate a higher lodging resistance of plants. In general, the monocotyledonous crop Avena sativa L. has a stronger physiological response to seed treatment with a suspension of nanoparticles than the dicotyledonous crop Medicago sativa L. The pre-sowing seed treatment of oat and lucerne induced changes in the microbial community of their rhizospheres: on the one hand, it increased proportions of nitrifying and phosphate mobilizing bacteria, as well as cellulose-decomposing actinomycetes; on the other hand, it reduced population density of microscopic fungi, while increasing a taxonomic diversity of soil fungi. In general, these findings demonstrate the improved environmental situation in rhizospheres of plants and reduced risk of root rot.
      PubDate: 2017-06-18
      DOI: 10.1007/s12668-017-0419-x
  • Biosynthesis of Zinc Oxide Nanoparticles Using Plant Extracts of Aloe vera
           and Hibiscus sabdariffa : Phytochemical, Antibacterial, Antioxidant and
           Anti-proliferative Studies
    • Authors: D. Mahendiran; G. Subash; D. Arumai Selvan; Dilaveez Rehana; R. Senthil Kumar; A. Kalilur Rahiman
      Abstract: The zinc oxide (ZnO) nanoparticles were successfully synthesized by using aqueous extracts of Aloe vera gel/leaf and Hibiscus sabdariffa leaf, and characterized by FT IR, UV-Vis, XRD, SEM, and EDX techniques. For comparison purposes, ZnO nanoparticles was also synthesized by chemical method. Phytochemical screening of the A. vera gel and leaf and H. sabdariffa leaf extracts showed the presence of alkaloids, carbohydrates, flavonoids, gums and mucilages, saponins, phenolic compounds, tannins, and terpenoids. FT IR spectra showed the presence of functional groups and protein as the stabilizing agent surrounding the ZnO nanoparticles. UV-Vis spectra of ZnO nanoparticles exhibit the characteristic absorption band in the range of 344–360 nm, which can be assigned to the intrinsic bandgap absorption of ZnO due to the electron transitions from the valence band to the conduction band. Powder XRD patterns confirmed the hexagonal wurtzite structure. Further, the SEM analysis also indicates the hexagonal rod shape structure of the ZnO nanoparticles. EDX spectra confirmed the chemical composition of the ZnO nanoparticles synthesized by both biological and chemical methods. In vitro antibacterial activity of ZnO nanoparticles synthesized by both biological and chemical methods were performed on three Gram (−ve) (Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa) and one Gram (+ve) (Staphylococcus aureus) bacteria, in which the ZnO nanoparticles obtained by biological method showed excellent bactericidal activity over that obtained by chemical method. All the ZnO nanoparticles showed promising antioxidant activity determined by five different methods such as 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS); 2,2′-diphenyl-1-picrylhydrazyl (DPPH); hydrogen peroxide (H2O2); superoxide radical scavenging; and hydroxyl radical scavenging assays. In vitro cytotoxicity of the ZnO nanoparticles were tested against three cancerous cell lines such as human breast adenocarcinoma (MCF-7), cervical (HeLa) and epithelioma (Hep-2), and one normal human dermal fibroblasts (NHDF) cell lines by MTT assay. Apoptosis induction was further confirmed by flow cytometry and cell cycle arrest. The ZnO nanoparticles obtained by biological method display remarkable cytotoxicity against the MCF-7 cell line, and found to be more potent than the widely used drug cisplatin.
      PubDate: 2017-06-09
      DOI: 10.1007/s12668-017-0418-y
  • Chitosan-Gellan Gum Bipolymeric Nanohydrogels—a Potential Nanocarrier
           for the Delivery of Epigallocatechin Gallate
    • Authors: Shakti Dahiya; Ruma Rani; Sandeep Kumar; Dinesh Dhingra; Neeraj Dilbaghi
      Abstract: Encapsulation of a hydrophilic drug into a polymeric matrix always remains a challenging process due to poor loading and retention capacity. A novel nanoscale drug delivery system, i.e., nanohydrogels, has been developed by virtue of combination of ionotropic gelation and polyelectrolyte complexation technique for the delivery of a popular hydrophilic drug, (−)-epigallocatechin gallate (EGCG). EGCG is one of the popular bioactive compounds present in green tea. Chitosan and gellan gum were used as cationic and anionic polysaccharides, and magnesium chloride was used as cross-linking agent for the synthesis of nanohydrogels in the present study. Effects of polymers and cross-linker were optimized using a three-level two-factor central composite Design-Expert Software. The final optimized EGCG-loaded nanohydrogels were evaluated for particle size, encapsulation efficiency, stability, and morphological and drug release studies. Comparative antioxidant and antibacterial potentials of EGCG-loaded nanohydrogels and EGCG were examined. EGCG-loaded nanohydrogels show more antioxidant and antibacterial potential at the same dose level as compared to the pure EGCG. Therefore, advanced nanoscale drug delivery systems with a reduced dose level and significant effectiveness over the conventional systems may increase their use in the near future for the betterment of healthcare applications.
      PubDate: 2017-06-03
      DOI: 10.1007/s12668-017-0416-0
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