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CHEMISTRY (598 journals)                  1 2 3 | Last

Showing 1 - 200 of 735 Journals sorted alphabetically
2D Materials     Hybrid Journal   (Followers: 10)
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 26)
ACS Catalysis     Full-text available via subscription   (Followers: 38)
ACS Chemical Neuroscience     Full-text available via subscription   (Followers: 18)
ACS Combinatorial Science     Full-text available via subscription   (Followers: 23)
ACS Macro Letters     Full-text available via subscription   (Followers: 24)
ACS Medicinal Chemistry Letters     Full-text available via subscription   (Followers: 39)
ACS Nano     Full-text available via subscription   (Followers: 252)
ACS Photonics     Full-text available via subscription   (Followers: 12)
ACS Synthetic Biology     Full-text available via subscription   (Followers: 23)
Acta Chemica Iasi     Open Access   (Followers: 2)
Acta Chimica Sinica     Full-text available via subscription   (Followers: 1)
Acta Chimica Slovaca     Open Access   (Followers: 1)
Acta Chimica Slovenica     Open Access  
Acta Chromatographica     Full-text available via subscription   (Followers: 9)
Acta Facultatis Medicae Naissensis     Open Access  
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 5)
Acta Scientifica Naturalis     Open Access   (Followers: 2)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 5)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 8)
Adsorption Science & Technology     Full-text available via subscription   (Followers: 5)
Advanced Functional Materials     Hybrid Journal   (Followers: 51)
Advanced Science Focus     Free   (Followers: 3)
Advances in Chemical Engineering and Science     Open Access   (Followers: 57)
Advances in Chemical Science     Open Access   (Followers: 13)
Advances in Chemistry     Open Access   (Followers: 15)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Enzyme Research     Open Access   (Followers: 9)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 8)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 16)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 9)
Advances in Materials Physics and Chemistry     Open Access   (Followers: 21)
Advances in Nanoparticles     Open Access   (Followers: 15)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15)
Advances in Polymer Science     Hybrid Journal   (Followers: 41)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Science and Technology     Full-text available via subscription   (Followers: 12)
African Journal of Bacteriology Research     Open Access  
African Journal of Chemical Education     Open Access   (Followers: 2)
African Journal of Pure and Applied Chemistry     Open Access   (Followers: 7)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
Al-Kimia : Jurnal Penelitian Sains Kimia     Open Access  
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 66)
American Journal of Biochemistry and Molecular Biology     Open Access   (Followers: 15)
American Journal of Chemistry     Open Access   (Followers: 27)
American Journal of Plant Physiology     Open Access   (Followers: 14)
American Mineralogist     Hybrid Journal   (Followers: 14)
Analyst     Full-text available via subscription   (Followers: 39)
Angewandte Chemie     Hybrid Journal   (Followers: 179)
Angewandte Chemie International Edition     Hybrid Journal   (Followers: 229)
Annales UMCS, Chemia     Open Access   (Followers: 1)
Annals of Clinical Chemistry and Laboratory Medicine     Open Access   (Followers: 4)
Annual Reports in Computational Chemistry     Full-text available via subscription   (Followers: 3)
Annual Reports Section A (Inorganic Chemistry)     Full-text available via subscription   (Followers: 4)
Annual Reports Section B (Organic Chemistry)     Full-text available via subscription   (Followers: 8)
Annual Review of Chemical and Biomolecular Engineering     Full-text available via subscription   (Followers: 12)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 16)
Anti-Infective Agents     Hybrid Journal   (Followers: 3)
Antiviral Chemistry and Chemotherapy     Hybrid Journal   (Followers: 1)
Applied Organometallic Chemistry     Hybrid Journal   (Followers: 7)
Applied Spectroscopy     Full-text available via subscription   (Followers: 22)
Applied Surface Science     Hybrid Journal   (Followers: 28)
Arabian Journal of Chemistry     Open Access   (Followers: 6)
ARKIVOC     Open Access   (Followers: 2)
Asian Journal of Biochemistry     Open Access   (Followers: 1)
Atomization and Sprays     Full-text available via subscription   (Followers: 4)
Australian Journal of Chemistry     Hybrid Journal   (Followers: 7)
Autophagy     Hybrid Journal   (Followers: 2)
Avances en Quimica     Open Access   (Followers: 1)
Biochemical Pharmacology     Hybrid Journal   (Followers: 10)
Biochemistry     Full-text available via subscription   (Followers: 326)
Biochemistry Insights     Open Access   (Followers: 6)
Biochemistry Research International     Open Access   (Followers: 6)
BioChip Journal     Hybrid Journal  
Bioinorganic Chemistry and Applications     Open Access   (Followers: 9)
Bioinspired Materials     Open Access   (Followers: 5)
Biointerface Research in Applied Chemistry     Open Access   (Followers: 2)
Biointerphases     Open Access   (Followers: 1)
Biology, Medicine, & Natural Product Chemistry     Open Access   (Followers: 1)
Biomacromolecules     Full-text available via subscription   (Followers: 19)
Biomass Conversion and Biorefinery     Partially Free   (Followers: 10)
Biomedical Chromatography     Hybrid Journal   (Followers: 6)
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 3)
BioNanoScience     Partially Free   (Followers: 5)
Bioorganic & Medicinal Chemistry     Hybrid Journal   (Followers: 120)
Bioorganic & Medicinal Chemistry Letters     Hybrid Journal   (Followers: 85)
Bioorganic Chemistry     Hybrid Journal   (Followers: 10)
Biopolymers     Hybrid Journal   (Followers: 18)
Biosensors     Open Access   (Followers: 2)
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 1)
Bitácora Digital     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 2)
Bulletin of the Chemical Society of Japan     Full-text available via subscription   (Followers: 24)
Bulletin of the Korean Chemical Society     Hybrid Journal   (Followers: 1)
C - Journal of Carbon Research     Open Access   (Followers: 3)
Cakra Kimia (Indonesian E-Journal of Applied Chemistry)     Open Access  
Canadian Association of Radiologists Journal     Full-text available via subscription   (Followers: 3)
Canadian Journal of Chemistry     Hybrid Journal   (Followers: 10)
Canadian Mineralogist     Full-text available via subscription   (Followers: 5)
Carbohydrate Research     Hybrid Journal   (Followers: 26)
Carbon     Hybrid Journal   (Followers: 68)
Catalysis for Sustainable Energy     Open Access   (Followers: 7)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 8)
Catalysis Science and Technology     Free   (Followers: 7)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 3)
Catalysts     Open Access   (Followers: 8)
Cellulose     Hybrid Journal   (Followers: 7)
Cereal Chemistry     Full-text available via subscription   (Followers: 5)
ChemBioEng Reviews     Full-text available via subscription   (Followers: 1)
ChemCatChem     Hybrid Journal   (Followers: 8)
Chemical and Engineering News     Free   (Followers: 15)
Chemical Bulletin of Kazakh National University     Open Access  
Chemical Communications     Full-text available via subscription   (Followers: 70)
Chemical Engineering Research and Design     Hybrid Journal   (Followers: 25)
Chemical Research in Chinese Universities     Hybrid Journal   (Followers: 3)
Chemical Research in Toxicology     Full-text available via subscription   (Followers: 21)
Chemical Reviews     Full-text available via subscription   (Followers: 184)
Chemical Science     Open Access   (Followers: 22)
Chemical Technology     Open Access   (Followers: 16)
Chemical Vapor Deposition     Hybrid Journal   (Followers: 5)
Chemical Week     Full-text available via subscription   (Followers: 8)
Chemie in Unserer Zeit     Hybrid Journal   (Followers: 56)
Chemie-Ingenieur-Technik (Cit)     Hybrid Journal   (Followers: 24)
ChemInform     Hybrid Journal   (Followers: 8)
Chemistry & Biodiversity     Hybrid Journal   (Followers: 6)
Chemistry & Biology     Full-text available via subscription   (Followers: 30)
Chemistry & Industry     Hybrid Journal   (Followers: 5)
Chemistry - A European Journal     Hybrid Journal   (Followers: 146)
Chemistry - An Asian Journal     Hybrid Journal   (Followers: 15)
Chemistry and Materials Research     Open Access   (Followers: 20)
Chemistry Central Journal     Open Access   (Followers: 4)
Chemistry Education Research and Practice     Free   (Followers: 5)
Chemistry in Education     Open Access   (Followers: 9)
Chemistry International     Hybrid Journal   (Followers: 2)
Chemistry Letters     Full-text available via subscription   (Followers: 42)
Chemistry of Materials     Full-text available via subscription   (Followers: 246)
Chemistry of Natural Compounds     Hybrid Journal   (Followers: 9)
Chemistry World     Full-text available via subscription   (Followers: 22)
Chemistry-Didactics-Ecology-Metrology     Open Access   (Followers: 1)
ChemistryOpen     Open Access   (Followers: 2)
Chemkon - Chemie Konkret, Forum Fuer Unterricht Und Didaktik     Hybrid Journal  
Chemoecology     Hybrid Journal   (Followers: 4)
Chemometrics and Intelligent Laboratory Systems     Hybrid Journal   (Followers: 14)
Chemosensors     Open Access  
ChemPhysChem     Hybrid Journal   (Followers: 10)
ChemPlusChem     Hybrid Journal   (Followers: 2)
ChemTexts     Hybrid Journal  
CHIMIA International Journal for Chemistry     Full-text available via subscription   (Followers: 2)
Chinese Journal of Chemistry     Hybrid Journal   (Followers: 6)
Chinese Journal of Polymer Science     Hybrid Journal   (Followers: 10)
Chromatographia     Hybrid Journal   (Followers: 24)
Clay Minerals     Full-text available via subscription   (Followers: 10)
Cogent Chemistry     Open Access  
Colloid and Interface Science Communications     Open Access  
Colloid and Polymer Science     Hybrid Journal   (Followers: 10)
Colloids and Surfaces B: Biointerfaces     Hybrid Journal   (Followers: 6)
Combinatorial Chemistry & High Throughput Screening     Hybrid Journal   (Followers: 4)
Combustion Science and Technology     Hybrid Journal   (Followers: 19)
Comments on Inorganic Chemistry: A Journal of Critical Discussion of the Current Literature     Hybrid Journal   (Followers: 2)
Composite Interfaces     Hybrid Journal   (Followers: 6)
Comprehensive Chemical Kinetics     Full-text available via subscription   (Followers: 2)
Comptes Rendus Chimie     Full-text available via subscription  
Comptes Rendus Physique     Full-text available via subscription   (Followers: 1)
Computational and Theoretical Chemistry     Hybrid Journal   (Followers: 9)
Computational Biology and Chemistry     Hybrid Journal   (Followers: 11)
Computational Chemistry     Open Access   (Followers: 2)
Computers & Chemical Engineering     Hybrid Journal   (Followers: 9)
Coordination Chemistry Reviews     Full-text available via subscription   (Followers: 3)
Copernican Letters     Open Access   (Followers: 1)
Corrosion Series     Full-text available via subscription   (Followers: 6)
Critical Reviews in Biochemistry and Molecular Biology     Hybrid Journal   (Followers: 5)
Croatica Chemica Acta     Open Access  
Crystal Structure Theory and Applications     Open Access   (Followers: 4)
CrystEngComm     Full-text available via subscription   (Followers: 13)
Current Catalysis     Hybrid Journal   (Followers: 2)
Current Metabolomics     Hybrid Journal   (Followers: 5)
Current Opinion in Colloid & Interface Science     Hybrid Journal   (Followers: 9)
Current Opinion in Molecular Therapeutics     Full-text available via subscription   (Followers: 18)
Current Research in Chemistry     Open Access   (Followers: 8)
Current Science     Open Access   (Followers: 64)
Dalton Transactions     Full-text available via subscription   (Followers: 23)
Detection     Open Access   (Followers: 2)
Developments in Geochemistry     Full-text available via subscription   (Followers: 2)
Diamond and Related Materials     Hybrid Journal   (Followers: 12)
Dislocations in Solids     Full-text available via subscription  
Doklady Chemistry     Hybrid Journal  
Drying Technology: An International Journal     Hybrid Journal   (Followers: 4)
Eclética Química     Open Access   (Followers: 1)
Ecological Chemistry and Engineering S     Open Access   (Followers: 3)
Ecotoxicology and Environmental Contamination     Open Access  
Educación Química     Open Access   (Followers: 1)
Education for Chemical Engineers     Hybrid Journal   (Followers: 5)
EJNMMI Radiopharmacy and Chemistry     Open Access  

        1 2 3 | Last

Journal Cover BioNanoScience
  [SJR: 0.428]   [H-I: 10]   [5 followers]  Follow
   Partially Free Journal Partially Free Journal
   ISSN (Print) 2191-1630 - ISSN (Online) 2191-1649
   Published by Springer-Verlag Homepage  [2355 journals]
  • Effects of Serotonin Receptor Antagonist Methiothepin on Membrane
           Potential of Premotor Interneurons of Naïve and Learned Snails
    • Authors: Vyatcheslav V. Andrianov; Tatiana Kh. Bogodvid; Irina B. Deryabina; Aleksandra N. Golovchenko; Lyudmila N. Muranova; Khalil L. Gainutdinov
      Abstract: Abstract It was shown that the application of methiothepin, the antagonist of serotonin (5-HT) receptors, caused a decrease in the membrane potential of the high-threshold premotor interneurons LPa3 and RPa3 of the intact snails and its increase to the previous level after the subsequent application of 5-HT in vitro. The application of methiothepin also led to a decrease in the membrane potential of these neurons, but the subsequent application of 5-HT did not lead to the return of the membrane potential to the previous level in animals trained in defensive reflex. It can be assumed that conditioning of the defensive reflex causes a state change of the 5-HT receptor system of premotor interneurons of defensive behavior.
      PubDate: 2018-01-13
      DOI: 10.1007/s12668-017-0498-8
  • Preventing Common Hereditary Disorders through Time-Separated Twinning
    • Authors: Alexander Churbanov; Levon Abrahamyan
      Abstract: Abstract Biomedical advances have led to a relaxation of natural selection in the human population of developed countries. In the absence of strong purifying selection, spontaneous and frequently deleterious mutations tend to accumulate in the human genome and gradually increase the genetic load; that is, the frequency of potentially lethal genes in the gene pool. Gradual increase in incidence of many complex disorders suggests deleterious impact of the genetic load on human well-being. Recent advances in in vitro fertilization (IVF) combined with artificial twinning and transgenerational embryo cryoconservation offer the possibility of preventing significant accumulation of genetic load and reducing the incidence of hereditary disorders. Many complex diseases such as type 1 and 2 diabetes, autism, bipolar disorder, allergies, Alzheimer’s disease, and some cancers show significantly higher concordance in monozygotic (MZ) twins than in fraternal twins (dizygotic, DZ) or parent-child pairs, suggesting their etiology is strongly influenced by genetics. Preventing these diseases based on genetic data alone is frequently impossible due to the complex interplay between genetic and environmental factors. We hypothesize that the incidence of complex diseases could be significantly reduced in the future through a strategy based on time-separated twinning. This strategy involves the collection and fertilization of human oocytes followed by several rounds of artificial twinning. If preimplantation genetic screening (PGS) reports no aneuploidy or known Mendelian disorders, one of the MZ siblings would be implanted and the remaining embryos cryoconserved. Once the good health of the adult MZ sibling(s) is established, subsequent parenthood with the cryoconserved co-twins could substantially lower the incidence of hereditary disorders with complex etiology and virtually eradicate simple Mendelian disorders. The proposed method of artificial twinning has the potential to alleviate suffering and reduce the negative social impact induced by dysgenic effects associated with known and unknown genetic factors. Time-separated twinning has the capacity to prevent further accumulation of the genetic load and to provide source of isogenic embryonic stem cells for future regenerative therapies.
      PubDate: 2018-01-13
      DOI: 10.1007/s12668-017-0488-x
  • Whether Medical Schools in Russia Are Ready to Develop Successfully in the
           Twenty-first Century
    • Authors: Andrey Kiassov; Anisa Gumerova; Sayar Abdulkhakov; Rashat Faizullin; Marat Mrasov; Lenar Rashitov; Raushania Gaifullina; Rezeda Khasanova; Julia Oslopova; Albert Rizvanov
      Abstract: Abstract The main purpose of this work was to analyze the situation of the readiness of Russian medical schools to develop and implement new technologies such as bionanotechnology and technologies born as the result of the genome and the fourth industrial revolutions, which are at the intersection of various sciences and can become a breakthrough in the development of future medicine. The development of medical schools in Russia, special features of Russian medical education, types of medical schools, and their effectiveness at the present time are considered in the paper. However, the most interesting development of new technologies is that of the “fundamental specialties” of training in higher education—medical biochemistry, medical biophysics, and medical cybernetics. We assert that Russian medical schools attached to large, traditional universities, thanks to multidisciplinarity and convergence in scientific research and in education, are the most prepared to solve the tasks posed by the global challenges of our time.
      PubDate: 2018-01-06
      DOI: 10.1007/s12668-017-0495-y
  • Design of Dual Band Wireless Power and Data Through RF Transmission for
           Biomedical Implants
    • Authors: Dhoha Daoud; Maissa Daoud; Mohamed Ghorbel; Ahmed Ben Hamida
      Abstract: Abstract In this paper, a new data and power recovery architecture for biomedical microsystem implants is proposed. Our contribution aims to overcome problems resulted by the trade-off between transmission data rate and power consumption for systems using the same or the separate inductive link to transmit data and power to the implanted part. The dual separate channels of RF powering and data recovery parts are designed to achieve the back telemetry data and power supply. The RF power recovery system is based on a 4-MHz RF link signal. It provides a regulated 3.3 V for the stimulating stage and 0.9 V for data recovery stage. The receiver based on a non-coherent topology consists of a 3–5-GHz low-noise amplifier (LNA), a squarer, an integrator, and a high-speed decision stage. The LNA of cascaded by cascode inductive source degenerative approach is proposed to decrease the noise figure when respecting linearity and stability conditions. It dissipates 8.89 mA from the 0.9-V power supply. The pulse generator produces an output signal with a maximum power spectral density (PSD) of − 66 dBm/MHz. The power consumption of the data transmission system is approximately equal to 0.664 mW for the emitter and 9.17 mW for the receiver. Simulation results show that this configuration can achieve a 125-Mbps data rate and − 82 dBm at 125-Mbps receiving sensitivity. This topology was designed in 0.18-μm RF-CMOS technology.
      PubDate: 2018-01-06
      DOI: 10.1007/s12668-017-0472-5
  • Analysis of Apparent Catalytic Parameters of Multiple Molecular Forms of
           Human Plasma Butyrylcholinesterase by Activity Gel-Scanning Following
           Non-denaturing Electrophoresis
    • Authors: Patrick Masson; Sofya Lushchekina
      Abstract: Abstract Butyrylcholinesterase (BChE) in human plasma is composed of four molecular forms: C1 (monomer); C2, covalent conjugate between BChE monomer and albumin; C3, dimer; and C4, tetramer, the major form. Catalytic parameters of molecular forms were estimated at high substrate concentration after non-denaturing polyacrylamide gel electrophoresis by activity gel-scanning densitometry, using a chromogenic substrate (butyrylthiocholine (BTC)). Though catalytic parameters Kss (dissociation of enzyme substrate complex at high substrate concentration) and catalytic constants are apparent (phenomenological) parameters, results indicate that the four molecular forms of human BChE do not display significant differences in their catalytic behavior at high BTC concentration.
      PubDate: 2018-01-05
      DOI: 10.1007/s12668-017-0489-9
  • Approximation of the Dependency of Trace Elements Concentrations in
           Internal Media upon their Contents in Environment Objects
    • Authors: Tunakova Yulia Alekseevna; Novikova Svetlana Vladimirovna; Faizullin Rashat Iskanderovich; Valiev Vsevolod Sergeevich
      Abstract: Abstract Models that demonstrate the dependency of a trace element content in the internal milieu of an organism upon that in external media objects of the environment were developed to identify dominant factors in ecology-mediated microelement imbalance in a human body. Based on the sets of experimental data obtained on trace element concentrations in the internal milieu (fluids) of a human body (blood) and accumulating media (hair), external fluids (drinking water), and deposit media (soil and snow cover), the degree of approximation of dependencies captured with different models was estimated, with the most adequate ones chosen. Linear, cubic, logistic, sigmoidal, parabolic functions, a polynomial of the fourth and fifth degrees, the Nelder–Mead optimization algorithm, and a Boltzmann function were applied to evaluate the approximation degree by different models. The selection of internal and external media demonstrating the best approximation results is justified.
      PubDate: 2018-01-04
      DOI: 10.1007/s12668-017-0487-y
  • Intravenous Transplantation of Human Umbilical Cord Blood Mononuclear
           Cells Overexpressing Nerve Growth Factor Improves Spatial Memory in
           APP/PS1 Transgenic Mice with a Model of Alzheimer’s Disease
    • Authors: M. A. Mukhamedyarov; A. V. Leushina; A. E. Tikhonova; E. O. Petukhova; E. E. Garanina; R. Ben Taleb; M. S. Kaligin; Y. O. Mukhamedshina; A. A. Rizvanov; A. L. Zefirov; R. R. Islamov
      Abstract: Abstract Alzheimer’s disease is a progressive incurable neurodegenerative disease manifested by dementia and other cognitive disorders. Gene-cell therapy is one of the most promising trends in the development of treatment for Alzheimer’s disease. The study was aimed to evaluate the therapeutic potential of intravenous transplantation of human umbilical cord blood mononuclear cells (UCBMCs) transduced with adenoviral vectors overexpressing nerve growth factor (NGF) for the treatment of Alzheimer’s disease in an APP/PS1 transgenic mice model. The transplantation of NGF-expressing UCBMCs was found to improve spatial memory and decrease anxiety in APP/PS1 mice. Grafted cells and their expression of NGF were detected in the cortex and hippocampus of transgenic mice in the period up to 90 days after transplantation. Thus, gene-cell therapy based on the use of NGF-overexpressing UCBMCs is a promising approach for the development of Alzheimer’s disease treatments.
      PubDate: 2017-12-29
      DOI: 10.1007/s12668-017-0497-9
  • Effect of Curcumin and Gliotoxin on Rat Liver Myofibroblast Culture
    • Authors: Aygul K. Shafigullina; Olja Mijanovic; Reshad A. Prottoy; Margarita N. Zhuravleva; Marina O. Gomzikova; Anisa A. Gumerova; Albert A. Rizvanov; Andrey P. Kiyasov
      Abstract: Abstract Since the 1990s, when it was demonstrated by Hammel and others that liver fibrosis is reversible, researchers and physicians actively search for new antifibrotic therapies. In recent years, knowledge of liver fibrosis pathophysiology has greatly advanced and new cellular and molecular mechanisms were described. The cells that determine extracellular matrix components distribution are myofibroblasts, but their origin is diverse. They can be activated hepatic stellate cells (HSCs), portal fibroblasts (PF), or circulating mesenchymal stem cells of the bone marrow. Among large number of substrates to inhibit activation, to inhibit proliferation of myofibroblasts, and to induce their apoptosis we, chose curcumin and gliotoxin. Primarily, in the current work, we optimized the explantation culture method for isolation of hepatic myofibroblasts and received two different cultures—myofibroblasts of HSC and PF origin. Exposition of 50 μM curcumin and 0.1 μM gliotoxin was the most optimal; we observed suppression of hepatic myofibroblast activation and inhibition of their proliferation. These results extend the current knowledge of the cells within the liver fibrogenic populations and prove inhibitory influence of biologically active substances (curcumin and gliotoxin) on portal myofibroblasts.
      PubDate: 2017-12-29
      DOI: 10.1007/s12668-017-0494-z
  • Diversity of Bacterial Synthesis of Silver Nanoparticles
    • Authors: Aqib Javaid; Sandra Folarin Oloketuyi; Mohammad Mansoob Khan; Fazlurrahman Khan
      Abstract: Abstract There are growing demands for the synthesis of silver nanoparticles (AgNPs) using green technology approaches due to their cost-effective and eco-friendly nature. Although, there are considerable number of research reports available related to biological means such as using plants, fungi, and bacteria-assisted synthesis of silver nanoparticles. In recent trends, synthesis of AgNPs using bacteria is considered most attractive, simple, green, and cost-effective source(s). This leads to the increase in the number of reports on AgNPs synthesized by different bacterial genera (both gram-positive and gram-negative) and species. The present review article describes the diversity of bacteria (both gram-positive and gram-negative) capable of synthesizing AgNPs and possible applications of AgNPs. Thus, increasing the number of bacteria for the synthesis of AgNPs will be helpful to combat pathogenic bacteria and will open doors for novel avenues and applications.
      PubDate: 2017-12-28
      DOI: 10.1007/s12668-017-0496-x
  • Towards Tissue Engineering: 3D Study of Polyamide-6 Scaffolds
    • Authors: A. A. Mikhutkin; R. A. Kamyshinsky; T. Kh. Tenchurin; А. D. Shepelev; A. S. Orekhov; T. E. Grigoriev; V. G. Mamaguashvili; S. N. Chvalun; A. L. Vasiliev
      Abstract: Abstract The paper reports confocal laser scanning microscopy and scanning electron microscopy complex study of polyamide-6 scaffolds for tissue engineering. Various approaches of 3D reconstruction and analysis of porous space and fibrous structure are presented. The effective porosity and cell penetration into the scaffold are estimated, assuming the spherical shape of cells. These results are compared with the data, obtained by bubble point method. The average diameter of the fibers was estimated using both skeletonization and manual approach, and it was within the range of 3.4–4.1 μm. Cell penetration modeling revealed that the effective volume of the porous space depends on the size of the penetrating sphere, decreasing from nearly 90% for 6-μm sphere to 0.2% for 24-μm one. The influence of experimental conditions, namely 405, 473, 559, and 635-nm laser wavelength, different step sizes during laser scanning and media (distilled water, glycerol 70%, glycerol 90%, glycerol 100%, and cultural fluid RPMI-1648), on the results obtained by confocal laser scanning microscopy is considered. It was found strong dependence of laser wavelength on image quality.
      PubDate: 2017-12-26
      DOI: 10.1007/s12668-017-0493-0
  • Capabilities of Molecular-Based Allergen Diagnostics in Atopic Diseases
    • Authors: Irina Reshetnikova; Svetlana Khaiboullina; Elena Agafonova
      Abstract: Abstract One hundred thirty-one assays were performed to determine the level of specific IgE to major molecular components of the birch pollen—rBet v 1, timothy grass pollen—rPhl p1, rPhl p 5b, and house dust mites—nDer p1, rDer p2 as well as to the minor components of birch pollen—rBet v 2, rBet v 4, timothy grass pollen—rPhl p7, rPhl p 12, and house dust mites rDer p10 in patients with asthma (N = 66) and allergic rhinitis (N = 65). It is well established that sensitization to major and minor allergens facilitates the selection of an allergen for the allergen-specific immunotherapy (ASIT). According to the concept of molecular-based allergen diagnostics, the ASIT efficacy is expected to be high when IgЕ to major components are present and antibodies to minor components are absent. When elevated IgЕ levels to major and minor ASIT proteins are present, a moderate ASIT efficacy is expected.
      PubDate: 2017-12-21
      DOI: 10.1007/s12668-017-0491-2
  • Alexithymia as a Predictor of Worse Prognosis in Postural Phobic Vertigo
    • Authors: Radiy Esin; Elena Gorobets; Oleg Esin; Ilshat Khayrullin; Liliya Sakhapova; Denis Martyanov
      Abstract: Abstract Alexithymia is regarded as a predictor of many chronic physical and neurological diseases, but it has not yet been regarded in connection with different types of dizziness, especially postural phobic vertigo. Patients with alexithymia have difficulties in describing their feelings and sensations; especially, it touches upon the description of neurological symptoms. The authors examined 84 patients with postural phobic vertigo (PPV): in 14 patients, this disease developed as a result of Ménière’s disease (MD) (men—6, women—8, average age 42 ± 11 years); in 19 patients—as a result of benign paroxysmal positional vertigo (men—9, women—10, average age 49 ± 13 years); in 17 patients—after ischemic stroke in the posterior circulation (men—9, women—8, average age—59 ± 7 years); and in 34 patients with presbiataxia who did not tolerate stroke (men—21, women—13, average age—64 ± 12 years). Diagnosis of alexithymia was carried out with the help of the Toronto Alexithymia Scale (TAS) (Russian-language version). According to the results of TAS, 46 patients did not have alexithymia (A− group), 8 patients were in the border zone, and 30 patients corresponded the criteria of alexithymia (A+ group). Patients from the border zone were not evaluated. The patients were prescribed anti-anxiety treatment (beta-phenyl-gamma-aminobutyric acid hydrochloride 250 mg three times a day for 3 weeks). All patients from A− group noted a good effect of treatment, and only in two patients from A+ group, the positive effect was registered. The results of the research show that alexithymia is a predictor of a more severe course of postural phobic vertigo, which requires the development of special approaches to the treatment of this disorder in patients with such cognitive modality. Testing on alexithymia is advisable for all patients with PPV complaints.
      PubDate: 2017-12-20
      DOI: 10.1007/s12668-017-0490-3
  • Extraction and Serological Properties of Mycobacterium Cell Surface and
           Excreted Proteins
    • Authors: Kamil S. Khaertynov; Anna R. Valeeva; Arkadiy V. Ivanov; Malik N. Mukminov; Nail G. Urazov; Ilsiyar M. Khaertynova; Natalya M. Aleksandrova; Albina V. Moskvicheva; Marina A. Efimova; Rafail M. Akhmadeev; Elvira S. Samigullina; Alexey A. Nabatov; Eduard A. Shuralev
      Abstract: Abstract Modern medicine still faces the task of distinguishing active and latent tuberculosis cases at the early stage of the disease. Serological approaches have their advantages for their use in diagnostics. However, the progress of these approaches is ongoing but further progress is needed to meet the needs for this disease. Here, we extracted Mycobacterium tuberculosis H37Rv proteins from culture medium or from the cell surface and studied their reactivity with anti-M. tuberculosis serum in both ELISA and immunoblots. We found that M. tuberculosis surface proteins, extracted using dimethyl sulfoxide, with molecular weights in the range of 6.5–200 kDa, showed strong specific reactivity with anti-M. tuberculosis positive serum. While excreted proteins in the molecular weight range of 32–45 kDa had the highest reactivity. The latter was confirmed serologically when very weak signal was detected from the filtrate fractions compared to stronger activity from the Vivaspin 50 kDa MWCO retentates. Moreover, Mycobacterium bovis and tuberculosis proteins from the filter retentates had clear specific serum reactivity, which suggests that this approach can be used for differential diagnosis of two infections.
      PubDate: 2017-12-19
      DOI: 10.1007/s12668-017-0492-1
  • Neural Network Self-Learning Model for Complex Assessment of Drinking
           Water Safety for Consumers
    • Authors: Yulia Tunakova; Svetlana Novikova; Ivan Krasnyuk; Rashat Faizullin; Gulnara Gabdrakhmanova
      Abstract: Abstract We need to take into complex assessment a set of influencing factors of drinking water safety. This raises the task of developing an integrated methodology assessing the safety of drinking water that reaches the consumers. For the integrated assessment of the safety of drinking water, the method of clustering was chosen, namely, the neural network method of Kohonen self-organizing maps. Zones were separated by the method of cluster neural network analysis. The zones are characterized by different content of metal cations in drinking water, levels of carcinogenic and non-carcinogenic risk to the health of the child population, and the probability of the receipt of metal cations with potable water to consumers.
      PubDate: 2017-12-15
      DOI: 10.1007/s12668-017-0486-z
  • Serological Monitoring of Herd Immunity to Measles in Indicator Groups and
           Groups of Risk
    • Authors: Guzel Isaeva; Irina Reshetnikova; Yury Tyurin; Sergey Kulikov; Ekaterina Garanina; Niaz Khakimov
      Abstract: Abstract The analysis of herd immunity to measles in the Republic of Tatarstan indicates epidemiological well-being, with the values correlating with average values across the Russian Federation (RF) in the following indicator groups: 3–4 and 9–10 years of age. The proportion of antibody-negative individuals increases (in comparison with the average values across the RF) in the age groups of 16–17 and 23–28 years and older than 30 years that suggest the tendency to epidemiological unsafety in these age categories. High titers of anti-measles antibodies in the age groups older than 40 years might evidence about definitely increased post-infection immunity.
      PubDate: 2017-12-15
      DOI: 10.1007/s12668-017-0482-3
  • Depolymerized Chitosan Enhances the Lysis of Staphylococcus aureus Cells
           by Lysostaphin
    • Authors: Sergey Kulikov; Evgeniya Subakaeva; Pavel Zelenikhin; Yuriy Tyurin; Olga Ilinskaya
      PubDate: 2017-12-14
      DOI: 10.1007/s12668-017-0485-0
  • Power and Noise Optimization Techniques of RF Active Inductor Using
           Multi-Finger Gate Transistors
    • Authors: Mongia Mhiri; Aymen Ben Hammadi; Fayrouz Haddad; Sehmi Saad; Kamel Besbes
      Abstract: Abstract In this paper, an optimization technique for active inductor circuit forward noise, size area, and power dissipation is proposed through careful selection of the number of gate fingers N f of a nanoscale MOS transistor. According to simulation results, the application of supply voltage scaling and multi-gate finger transistor techniques can therefore introduce simultaneously a reduction in power consumption around 60% (from 3.35 to 1.32 mW) and a minimization in noise performance at 2 GHz from 3.15 to 2.1 ɳV/√Hz with a small size area and wide tuning range.
      PubDate: 2017-12-12
      DOI: 10.1007/s12668-017-0483-2
  • Imidazolium p-tert- Butylthiacalix[4]arene Amphiphiles—Aggregation in
           Water Solutions and Binding with Adenosine 5′-Triphosphate Dipotassium
    • Authors: Vladimir A. Burilov; Diana A. Mironova; Regina R. Ibragimova; Vladimir G. Evtugyn; Yurii N. Osin; Svetlana E. Solovieva; Igor S. Antipin
      Abstract: Abstract Aggregation properties of water-soluble cationic amphiphilic p-tert-butylthiacalix[4]arene derivatives adopting 1,3-alternate stereoisomeric form with methylimidazolyl headgroups were studied. It was found that derivatives 1 and 2 form stable aggregates in water solutions. The size and shape of aggregates were defined using DLS and TEM techniques. Critical aggregation concentration (CAC) of methylimidazolyl derivatives was calculated using dye micellization method. It was found that correct CAC determination of cationic amphiphiles using anionic xanthene dyes should be considered carefully in respect with electrostatic interactions. Using indicator displacement procedure, DLS studies, and 31P NMR spectroscopy, it was found that macrocycles 1 and 2 bind with ATP with 1:1 stoichiometry. It was found that ATP causes eosin Y release from binary thiacalixarene-eosin Y system up from 3 to 12 μM of ATP in the case of macrocycles 1 and 2, respectively.
      PubDate: 2017-12-08
      DOI: 10.1007/s12668-017-0484-1
  • Green Synthesis of Silver Nanoparticles and their Antifungal Properties
    • Authors: Parteek Prasher; Manjeet Singh; Harish Mudila
      Abstract: Abstract In this communication, the green synthesis of silver nanoparticles (AgNPs) and their antifungal applications have been reported. The starch-stabilized AgNPs tested on the fungal strain BWP17 of the Candida species were found to have a significant antifungal property with minimum inhibitory concentration (at 80% fungal inhibition, MIC80) of 0.28 mg/ml. The fungicidal property of the nanoparticles was supported by various in vitro staining assays. The modes of inhibition were deciphered by testing the nanoparticles for R6G influx-efflux assay as well as GCMS analysis. Lastly, cell viability assay for determining the toxicity profile of these nanoparticles was performed by using MTT assay kit. It was eventually concluded that the antifungal properties of the starch-stabilized AgNPs are based on cell membrane rupturing mechanism. Graphical Abstract ᅟ
      PubDate: 2017-12-06
      DOI: 10.1007/s12668-017-0481-4
  • Indication and Identification of Bacillus anthracis Isolates from the
           Middle Volga Region by Multi-Primer PCR
    • Authors: Natalya M. Aleksandrova; Tagir Kh. Faizov; Anna V. Vasileva; Inna A. Rogozhina; Nail I. Khammadov; Eduard A. Shuralev
      Abstract: Abstract The article describes the results of improved preparation of various object sampling for indication, identification and genotyping of Bacillus anthracis isolates with molecular genetic methods based on multilocus sequence typing using specific primers. Multi-primer PCR used enabled the detection and differentiation of B. anthracis isolates. The used primers allowed to differentiate isolates by their belonging to the genus Bacillus and B. anthracis species by the рХО1 plasmid presence. The detection of the рХ02 plasmid encoding for capsule formation indicates pathogenicity of the isolates studied. Using multi-primer PCR allowed to determine the epizootic situation of anthrax in the Middle Volga Region and to establish that two genotypic groups of the pathogen B. anthracis circulate in the region.
      PubDate: 2017-12-06
      DOI: 10.1007/s12668-017-0477-0
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