Subjects -> CHEMISTRY (Total: 986 journals)
    - ANALYTICAL CHEMISTRY (59 journals)
    - CHEMISTRY (713 journals)
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    - ELECTROCHEMISTRY (28 journals)
    - INORGANIC CHEMISTRY (45 journals)
    - ORGANIC CHEMISTRY (47 journals)
    - PHYSICAL CHEMISTRY (71 journals)

CHEMISTRY (713 journals)                  1 2 3 4 | Last

Showing 1 - 200 of 735 Journals sorted alphabetically
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 29)
ACS Applied Polymer Materials     Hybrid Journal   (Followers: 9)
ACS Catalysis     Hybrid Journal   (Followers: 51)
ACS Chemical Neuroscience     Hybrid Journal   (Followers: 21)
ACS Combinatorial Science     Hybrid Journal   (Followers: 21)
ACS Macro Letters     Hybrid Journal   (Followers: 25)
ACS Materials Letters     Open Access   (Followers: 2)
ACS Medicinal Chemistry Letters     Hybrid Journal   (Followers: 43)
ACS Nano     Hybrid Journal   (Followers: 189)
ACS Photonics     Hybrid Journal   (Followers: 15)
ACS Symposium Series     Full-text available via subscription   (Followers: 3)
ACS Synthetic Biology     Hybrid Journal   (Followers: 28)
Acta Chemica Malaysia     Open Access  
Acta Chimica Slovaca     Open Access   (Followers: 2)
Acta Chimica Slovenica     Open Access   (Followers: 2)
Acta Chromatographica     Full-text available via subscription   (Followers: 7)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 8)
Acta Scientifica Naturalis     Open Access   (Followers: 2)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 7)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 9)
Advanced Electronic Materials     Hybrid Journal   (Followers: 5)
Advanced Functional Materials     Hybrid Journal   (Followers: 70)
Advanced Journal of Chemistry, Section A     Open Access   (Followers: 3)
Advanced Journal of Chemistry, Section B     Open Access   (Followers: 1)
Advanced Science Focus     Free   (Followers: 5)
Advanced Theory and Simulations     Hybrid Journal   (Followers: 2)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Chemical Engineering and Science     Open Access   (Followers: 104)
Advances in Chemical Science     Open Access   (Followers: 50)
Advances in Chemistry     Open Access   (Followers: 34)
Advances in Chemistry     Full-text available via subscription   (Followers: 4)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 16)
Advances in Environmental Chemistry     Open Access   (Followers: 9)
Advances in Enzyme Research     Open Access   (Followers: 10)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8)
Advances in Materials Physics and Chemistry     Open Access   (Followers: 31)
Advances in Nanoparticles     Open Access   (Followers: 17)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Polymer Science     Hybrid Journal   (Followers: 50)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 18)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Science and Technology     Full-text available via subscription   (Followers: 16)
Aerosol Science and Engineering     Hybrid Journal  
African Journal of Bacteriology Research     Open Access  
African Journal of Chemical Education     Open Access   (Followers: 5)
African Journal of Pure and Applied Chemistry     Open Access   (Followers: 6)
Aggregate     Open Access  
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
Al-Kimia : Jurnal Penelitian Sains Kimia     Open Access  
Alchemy : Journal of Chemistry     Open Access   (Followers: 3)
Alchemy : Jurnal Penelitian Kimia     Open Access  
Alotrop     Open Access  
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 43)
American Journal of Biochemistry and Molecular Biology     Open Access   (Followers: 19)
American Journal of Chemistry     Open Access   (Followers: 37)
American Journal of Plant Physiology     Open Access   (Followers: 7)
Analyst     Hybrid Journal   (Followers: 36)
Analytical Science Advances     Open Access   (Followers: 1)
Angewandte Chemie     Hybrid Journal   (Followers: 155)
Angewandte Chemie International Edition     Hybrid Journal   (Followers: 227)
Annales Universitatis Mariae Curie-Sklodowska, sectio AA – Chemia     Open Access   (Followers: 1)
Annals of Clinical Chemistry and Laboratory Medicine     Open Access   (Followers: 6)
Annual Reports in Computational Chemistry     Full-text available via subscription   (Followers: 4)
Annual Review of Chemical and Biomolecular Engineering     Full-text available via subscription   (Followers: 12)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 14)
Applied Organometallic Chemistry     Hybrid Journal   (Followers: 7)
Applied Surface Science     Hybrid Journal   (Followers: 30)
Arabian Journal of Chemistry     Open Access   (Followers: 4)
ARKIVOC     Open Access   (Followers: 1)
Asian Journal of Applied Chemistry Research     Open Access   (Followers: 1)
Asian Journal of Biochemistry     Open Access   (Followers: 2)
Asian Journal of Chemical Sciences     Open Access   (Followers: 1)
Asian Journal of Chemistry and Pharmaceutical Sciences     Open Access  
Asian Journal of Physical and Chemical Sciences     Open Access   (Followers: 2)
Atomization and Sprays     Full-text available via subscription   (Followers: 7)
Australian Journal of Chemistry     Hybrid Journal   (Followers: 7)
Autophagy     Hybrid Journal   (Followers: 7)
Avances en Quimica     Open Access  
Biochemical Pharmacology     Hybrid Journal   (Followers: 11)
Biochemistry     Hybrid Journal   (Followers: 203)
Biochemistry Research International     Open Access   (Followers: 5)
BioChip Journal     Hybrid Journal  
Bioinorganic Chemistry and Applications     Open Access   (Followers: 5)
Biointerface Research in Applied Chemistry     Open Access  
Biointerphases     Open Access   (Followers: 1)
Biology, Medicine, & Natural Product Chemistry     Open Access   (Followers: 2)
Biomacromolecules     Hybrid Journal   (Followers: 22)
Biomass Conversion and Biorefinery     Partially Free   (Followers: 10)
Biomedical Chromatography     Hybrid Journal   (Followers: 6)
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 3)
BioNanoScience     Partially Free   (Followers: 3)
Bioorganic & Medicinal Chemistry     Hybrid Journal   (Followers: 93)
Bioorganic & Medicinal Chemistry Letters     Hybrid Journal   (Followers: 66)
Bioorganic Chemistry     Hybrid Journal   (Followers: 9)
Biopolymers     Hybrid Journal   (Followers: 15)
Biosensors     Open Access   (Followers: 3)
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 1)
Bitácora Digital     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Bulletin of Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences     Open Access  
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 1)
Bulletin of the Chemical Society of Japan     Full-text available via subscription   (Followers: 24)
Bulletin of the Korean Chemical Society     Hybrid Journal   (Followers: 1)
C - Journal of Carbon Research     Open Access   (Followers: 5)
Cakra Kimia (Indonesian E-Journal of Applied Chemistry)     Open Access  
Canadian Journal of Chemistry     Hybrid Journal   (Followers: 12)
Canadian Mineralogist     Full-text available via subscription   (Followers: 5)
Carbohydrate Polymer Technologies and Applications     Open Access  
Carbohydrate Polymers     Hybrid Journal   (Followers: 8)
Carbohydrate Research     Hybrid Journal   (Followers: 24)
Carbon     Hybrid Journal   (Followers: 65)
Carbon Capture Science & Technology     Open Access   (Followers: 5)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 9)
Catalysis Science and Technology     Hybrid Journal   (Followers: 9)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 4)
Catalysts     Open Access   (Followers: 11)
Cell Reports Physical Science     Open Access  
Cellulose     Hybrid Journal   (Followers: 8)
Cereal Chemistry     Full-text available via subscription   (Followers: 4)
Chem     Hybrid Journal   (Followers: 9)
Chem Catalysis     Hybrid Journal   (Followers: 6)
ChemBioEng Reviews     Full-text available via subscription   (Followers: 3)
ChemCatChem     Hybrid Journal   (Followers: 8)
Chemical and Engineering News     Free   (Followers: 21)
Chemical Bulletin of Kazakh National University     Open Access  
Chemical Communications     Hybrid Journal   (Followers: 81)
Chemical Engineering Research and Design     Hybrid Journal   (Followers: 25)
Chemical Physics Impact     Full-text available via subscription   (Followers: 5)
Chemical Research in Chinese Universities     Hybrid Journal   (Followers: 4)
Chemical Research in Toxicology     Hybrid Journal   (Followers: 22)
Chemical Reviews     Hybrid Journal   (Followers: 176)
Chemical Science     Open Access   (Followers: 39)
Chemical Science International Journal     Open Access  
Chemical Technology     Open Access   (Followers: 74)
Chemical Thermodynamics and Thermal Analysis     Open Access   (Followers: 7)
Chemical Vapor Deposition     Hybrid Journal   (Followers: 4)
Chemie in Unserer Zeit     Hybrid Journal   (Followers: 54)
Chemie-Ingenieur-Technik (Cit)     Hybrid Journal   (Followers: 21)
ChemInform     Hybrid Journal   (Followers: 5)
Chemistry & Biodiversity     Hybrid Journal   (Followers: 7)
Chemistry & Industry     Full-text available via subscription   (Followers: 6)
Chemistry - A European Journal     Hybrid Journal   (Followers: 125)
Chemistry - An Asian Journal     Hybrid Journal   (Followers: 19)
Chemistry Africa : A Journal of the Tunisian Chemical Society     Hybrid Journal  
Chemistry and Materials Research     Open Access   (Followers: 17)
Chemistry Central Journal     Open Access   (Followers: 4)
Chemistry Education Research and Practice     Free   (Followers: 6)
Chemistry Education Review     Open Access   (Followers: 1)
Chemistry in Education     Open Access   (Followers: 3)
Chemistry Letters     Full-text available via subscription   (Followers: 44)
Chemistry of Heterocyclic Compounds     Hybrid Journal   (Followers: 5)
Chemistry of Materials     Hybrid Journal   (Followers: 160)
Chemistry of Natural Compounds     Hybrid Journal   (Followers: 10)
Chemistry World     Hybrid Journal   (Followers: 20)
Chemistry-Didactics-Ecology-Metrology     Open Access  
ChemistryOpen     Open Access   (Followers: 1)
ChemistrySelect     Hybrid Journal   (Followers: 1)
Chemistry–Methods     Open Access   (Followers: 1)
Chemkon - Chemie Konkret, Forum Fuer Unterricht Und Didaktik     Hybrid Journal  
ChemNanoMat     Hybrid Journal   (Followers: 1)
Chemoecology     Hybrid Journal   (Followers: 2)
Chemometrics and Intelligent Laboratory Systems     Hybrid Journal   (Followers: 13)
ChemPhotoChem     Hybrid Journal  
ChemPhysChem     Hybrid Journal   (Followers: 12)
ChemPhysMater     Full-text available via subscription   (Followers: 8)
ChemPlusChem     Hybrid Journal   (Followers: 2)
Chempublish Journal     Open Access  
ChemSystemsChem     Hybrid Journal   (Followers: 1)
ChemTexts     Hybrid Journal   (Followers: 1)
CHIMIA International Journal for Chemistry     Open Access   (Followers: 2)
Chinese Journal of Chemistry     Hybrid Journal   (Followers: 6)
Chinese Journal of Polymer Science     Hybrid Journal   (Followers: 9)
Chromatographia     Hybrid Journal   (Followers: 22)
Chromatography     Open Access   (Followers: 2)
Chromatography Research International     Open Access   (Followers: 4)
Ciencia     Open Access  
Clay Minerals     Hybrid Journal   (Followers: 7)
Cogent Chemistry     Open Access   (Followers: 3)
Colloid and Interface Science Communications     Open Access  
Colloid and Polymer Science     Hybrid Journal   (Followers: 6)
Colloids and Surfaces B: Biointerfaces     Hybrid Journal   (Followers: 8)
Combinatorial Chemistry & High Throughput Screening     Hybrid Journal   (Followers: 2)
Combustion Science and Technology     Hybrid Journal   (Followers: 26)
Comments on Inorganic Chemistry: A Journal of Critical Discussion of the Current Literature     Hybrid Journal   (Followers: 1)
Communications Chemistry     Open Access   (Followers: 2)
Communications Materials     Open Access  
Composite Interfaces     Hybrid Journal   (Followers: 6)
Comptes Rendus : Chimie     Open Access  
Comptes Rendus : Physique     Open Access   (Followers: 2)
Computational and Theoretical Chemistry     Hybrid Journal   (Followers: 11)
Computational Biology and Chemistry     Hybrid Journal   (Followers: 13)
Computational Chemistry     Open Access   (Followers: 4)
Computers & Chemical Engineering     Hybrid Journal   (Followers: 11)
Coordination Chemistry Reviews     Full-text available via subscription   (Followers: 6)
Corrosion Communications     Open Access   (Followers: 5)
Critical Reviews in Biochemistry and Molecular Biology     Hybrid Journal   (Followers: 17)
Croatica Chemica Acta     Open Access  
CrystEngComm     Hybrid Journal   (Followers: 10)

        1 2 3 4 | Last

Similar Journals
Journal Cover
Chemistry of Heterocyclic Compounds
Journal Prestige (SJR): 0.325
Citation Impact (citeScore): 1
Number of Followers: 5  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1573-8353 - ISSN (Online) 0009-3122
Published by Springer-Verlag Homepage  [2469 journals]
  • New methods for the synthesis of phosphono-δ-lactones (microreview)

    • Free pre-print version: Loading...

      Abstract: Phosphono-δ-lactones are widely used as bioactive compounds, flame retardants, and polymer building blocks. Over the past years, new methods to access this heterocycle have been developed, some of them using innovative methodologies, like electrochemistry or photocatalysis. The current microreview covers selected methods over the past 5 years.
      PubDate: 2022-01-23
       
  • Regioselective [3+2] cycloaddition of nitrile oxides to
           1Н-pyrrole-2,3-diones: synthesis of spiro[pyrroledioxazoles]

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      Abstract: 1,3-Dipolar cycloaddition of 1H-pyrrole-2,3-diones to nitrile oxides generated in situ from N-hydroxybenzimidoyl chlorides by the action of triethylamine proceeds regioselectively with the formation of 1,4,2-dioxazoles spiro-condensed with the pyrrol-2-one fragment.
      PubDate: 2022-01-23
       
  • Reductive rearrangement of 2-aroyl-2,3-dihydrobenzofurans into
           2-hydroxydihydrochalcones and flav-2-enes

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      Abstract: A two-step procedure was proposed for the synthesis of 2-aryl- and 2,4-diaryl-substituted 4H-chromenes by the formal [4+1] cycloaddition reaction of o-quinone methides and pyridinium ylides followed by reductive rearrangement of 2-aroyl-2,3-dihydrobenzofurans by the action of zinc in acetic acid or samarium and trimethylchlorosilane in 1,4-dioxane. The reduction of 3-unsubstituted 2-aroyl-2,3-dihydrobenzofurans by the action of zinc in acetic acid leads mainly to 2-hydroxydihydrochalcones.
      PubDate: 2022-01-23
       
  • Synthesis of five-membered heterocycles by [3+2] cycloaddition reactions
           of sulfur-containing 3,3,3-trifluoropropene derivatives

    • Free pre-print version: Loading...

      Abstract: The present minireview provides a survey of literature reports on the application of 3,3,3-trifluoropropene derivatives bearing sulfur-containing functional groups at positions 1 or 2 in the synthesis of functionalized five-membered heterocycles – pyrroles, pyrrolines, pyrrolidines, tetrahydrothiophenes, pyrazoles, pyrazolines, pyrazolidines, isoxazoles, isoxazolines, isoxazolidines, and triazoles via [3+2] cycloaddition reactions with 1,3-dipolarophiles.
      PubDate: 2022-01-17
       
  • Correction to: Aziridine-2-Carboxylic Acid Derivatives and Its Open-Ring
           Isomers as a Novel PDIA1 Inhibitors

    • Free pre-print version: Loading...

      PubDate: 2022-01-11
       
  • Aziridine-2-carboxylic acid derivatives and its open-ring isomers as a
           novel PDIA1 inhibitors

    • Free pre-print version: Loading...

      Abstract: Acyl derivatives of aziridine-2-carboxylic acid have been synthesized and tested as PDIA1 inhibitors. Calculations of charge value and distribution in aziridine ring system and some alkylating agents were performed. For the first time was found that acyl derivatives of aziridine-2-carboxylic acid are weak to moderately active PDIA1 inhibitors.
      PubDate: 2022-01-07
       
  • Synthesis of 2H-thiochromene derivatives (microreview)

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      Abstract: The microreview considers recent methodologies for the synthesis of 2H-thiochromenes including enantioselective synthesis, multistep synthesis, o-halobenzaldehyde-based reactions, intramolecular alkyne iodo/hydroarylation reaction, tetramethylguanidine-catalyzed reaction, and sequential one-pot Cu/Pd-catalyzed reaction. Selected articles published since 2016 are covered.
      PubDate: 2022-01-06
       
  • Synthesis and permethylation of methyl 5-(2-chloropyridin-3-yl)pentanoates

    • Free pre-print version: Loading...

      Abstract: Two methyl 5-(2-chloropyridin-3-yl)pentanoates were prepared by condensation of 1,3-bis(silyloxy)-1,3-butadienes with 2-chloropyridine-3-carboxylic acid chloride. The permethylation of the products resulted in two completely different products, depending on the substitution pattern of the 1,3,5-tricarbonyl moiety.
      PubDate: 2022-01-06
       
  • Synthesis of heterocyclic ring-fused quinones (microreview)

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      Abstract: This microreview presents the data on the methods of synthesis of heterocyclic ring-fused quinones over the period from 2015 to 2021.
      PubDate: 2022-01-06
       
  • [3+2] Cycloaddition reactions of 1-substituted 3,3,3-trifluoropropenes
           with diazo compounds and nitrilimines – synthesis of pyrazolines and
           pyrazoles

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      Abstract: 1,3-Dipolar cycloaddition reactions of 3,3,3-trifluoropropene derivatives containing a sulfonyl, sulfamide, or sulfoximine substituent in position 1 with diazomethane proceed with the formation of 3-substituted 4-(trifluoromethyl)-4,5-dihydro-1H-pyrazoles and 3-(trifluoromethyl)-1H-pyrazole, whereas reactions with ethyl diazoacetate and 2,2,2-trifluorodiazoethane lead to the formation of isomeric 5(3)-substituted 4-trifluoromethyl-3,4(4,5)-dihydro-2(1)H-pyrazoles and 4-substituted 5-(trifluoromethyl)-4,5-dihydro-1Hpyrazoles, the stability of which depends on the nature of the heteroatomic substituent. The cycloaddition of 1-sulfonyl- and 1-sulfamoylsubstituted derivatives of 3,3,3-trifluoropropene to C-carbethoxy-N-phenylnitrilimine gives rise to 4-substituted ethyl 1-phenyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazole-3-carboxylates and ethyl 1-phenyl-4-(trifluoromethyl)-1H-pyrazole-3-carboxylate.
      PubDate: 2022-01-06
       
  • Synthesis of methyl(ethyl) pyrazolo[4,3-b]pyridine-6-carboxylates and
           their conversion to tert-butyl
           4,5,6,7-tetrahydropyrazolo-[4,3-b]pyridine-6-carboxylates

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      Abstract: N-Boc-4-aminopyrazole-5-carbaldehydes react with methyl 3,3-dimethoxypropanoate or β-keto esters in acetic acid under reflux to form methyl(ethyl) pyrazolo[4,3-b]pyridine-6-carboxylates, which were converted to the corresponding tert-butyl carboxylates via intermediate carboxylic acids. Their subsequent hydrogenation on a 10% Pd/C catalyst at 100°C and 25 atm afforded tert-butyl 4,5,6,7-tetrahydropyrazolo[4,3-b]pyridine-6-carboxylates.
      PubDate: 2022-01-06
       
  • Synthetic transformations of sesquiterpene lactones. Controllable
           synthesis of 11,13-dihydroisoalantolactone azides and
           13-(1,2,3-triazolyl)eudesmanolides based on sesquiterpene lactones

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      Abstract: Modification of eudesmane-type lactones isoalantolactone and 4,15-epoxyisoalantolactone was carried out at the active methylene group. The reaction of isoalantolactone with hydrazoic acid, which was formed in situ from sodium azide and acetic acid in the presence of triethylamine in toluene or DMF, proceeds in a controllable manner and, depending on the nature of the solvent and reaction conditions, leads to (11R)-13-azido-11,13-dihydroisoalantolactone, the spirocyclic compound (11R)-aziridino[11,13]dihydroisoalantolactone, and the product of the selective opening of the aziridine ring with the azide anion (11S)-11-amino-13-azido-11,13-dihydroisoalantolactone. The reaction of 4,15-epoxyisoalantolactone with hydrazoic acid proceeds similarly to form the corresponding 13-azido-, (11R)-aziridino[11,13]-, or (11S)-11-amino-13-azido-4,15-epoxy-11,13-dihydroisoalantolactones. The regioselective synthesis of libraries of (11R)-13-(1H-1,2,3-triazolyl)-11,13-dihydroisoalantolactones and (11S)-11-amino-13-(1H-1,2,3-triazolyl)-11,13-dihydroisoalantolactones containing various aryl or hetaryl substituents at the C-4 position of the triazole ring was carried out by the CuAAC reaction of 13-azido-substituted 11,13-dihydroisoalantolactones with terminal acetylenes.
      PubDate: 2022-01-06
       
  • Reactivity of alicyclic 1,5,9-triketones toward five-, six-, and
           seven-membered rings in acidic medium. Stereochemistry of intramolecular
           cyclization products

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      Abstract: Among nine alicyclic 1,5,9-triketones with differently fused 5-, 6-, and 7-membered rings in the molecule, existing as mixtures of 3–6 diastereomers, only those containing at least two 6-membered rings were capable of intramolecular cyclization in acidic medium (HCl, EtOH). The diastereomer mixture underwent stereoselective transformation, giving one major cyclization product. The relative configuration of chiral centers in cyclization products obtained under acidic or basic conditions was compared by X-ray crystallography. The differences were caused by divergent stereochemical outcome at the first stage of cyclization.
      PubDate: 2022-01-04
       
  • Lewis acid catalyzed condensation of 2-aminohetarene N-oxides with
           N,N-dimethylformamide dimethyl acetal

    • Free pre-print version: Loading...

      Abstract: A method for the introduction of the N,N-dimethylformamidine protective group in a series of six-membered 2-aminohetarene N-oxides was developed. It was shown that 2-amino derivatives of N-oxides of various six-membered heterocycles (pyridines, pyrimidines, pyrazines, tetrazines) successfully enter the reaction. The stability of the N,N-dimethylformamidine protecting group in 2-aminohetarene N-oxides was found to depend on the type of reaction medium.
      PubDate: 2022-01-04
       
  • Pyrazoles, isoxazoles, and 1,2,3-triazoles as analogs of the natural
           cytostatic combretastatin A-4: efficient routes of synthesis, tubulin
           inhibition, and cytotoxicity

    • Free pre-print version: Loading...

      Abstract: The review discusses the advantages and disadvantages of combretastatin A-4, presents the most effective methods for the synthesis of its 1,2,3-triazole, pyrazole, isoxazole analogs. The structural formulas of the analogs of combretastatin A-4 which are the most active against cancer cells, together with indicators of cytotoxicity, are also presented.
      PubDate: 2022-01-04
       
  • Synthesis of pyrimido[1,2-a]indoles (minireview)

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      Abstract: This review considers methods for the synthesis of pyrimido[1,2-a]indoles and their ring-fused derivatives, covering publications from the last 10 years. Depending on the synthons used for assembling the target structure, three main approaches to the synthesis of pyrimido-[1,2-a]indoles can be distinguished: annulation of a pyrimidine ring to 2-aminoindoles, modification of other indole derivatives, and miscellaneous methods.
      PubDate: 2021-10-01
       
  • New methods for the synthesis of pyrrolo[1,2-x][1,4]diazepines and their
           (het)arene-annulated analogs (microreview)

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      Abstract: The microreview is devoted to the original synthetic methodologies toward pyrrolo[1,2-x][1,4]diazepines and their (het)arene-annulated analogs published over the past 10 years. The approaches are divided into two groups depending on the starting compounds: annulation of the diazepine ring to the pyrrole fragment and simultaneous formation of pyrrole and diazepine rings via dicarbonyl intermediates.
      PubDate: 2021-10-01
       
  • Features of the reaction of 1-amino-2-nitroguanidine with isatins.
           Synthesis of [1,2,4]triazino[5,6-b]indoles

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      Abstract: Reactions of 1-amino-2-nitroguanidine with isatins leading to the formation of new β-(2-nitro)guanidinohydrazones of isatin, which exist as E/Z-isomers in regards to the azomethine fragment, were studied. It was found that the conditions of the reactions of 1-amino- 2-nitroguanidine with isatins affect the geometry of the formed hydrazones. Conditions for the cyclization of the obtained (Z)-β-(2-nitro)- guanidinohydrazones leading to 3-nitroimino-containing [1,2,4]triazino[5,6-b]indoles were proposed.
      PubDate: 2021-10-01
       
  • Synthesis and Anticancer Activity of 11-azaartemisinin Derivatives Bearing
           1,2,3-triazole Moiety

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      Abstract: A series of new compounds were prepared under mild reaction conditions using click reaction of 11-azaartemisinin and various azides. All the synthesized compounds were fully characterized by spectral data and evaluated for their cytotoxic activity against KB and HepG2 cell lines. All synthesized artemisinin derivatives are more active than 11-azaartemisinin. Thirteen of the synthesized compounds displayed good cytotoxic activity against two human cancer cell lines, KB and HepG2, with half maximal inhibitory concentration values in a range of 4.27–70.40 μM. The most active derivative was the best to both KB and HepG2 cell lines with IC50 value of 10.18 and 4.27 μM, respectively.
      PubDate: 2021-10-01
       
  • Facile Synthesis and Spectral Properties of Novel Isomeric Nitrile-Rich
           Bipyridine Derivatives

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      Abstract: A series of novel cyano-substituted bipyridine derivatives were obtained in good yields (45–72%) via the reaction of malononitrile dimer with isomeric azachalcones. For all synthesized compounds, spectral-fluorescent properties were carefully investigated, and correlation thereof with chemical structure was found. The developed approach represents a novel convenient method for the preparation of functionalized bipyridines containing unique combination of structural fragments.
      PubDate: 2021-10-01
       
 
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