JournalTOCs

Indian Journal of Chemistry - Section B (IJC-B)
Journal Prestige (SJR): 0.162

Number of Followers: 12

This is an Open Access Journal

Open Access journal
ISSN (Print) 0376-4699 - ISSN (Online) 0975-0983
Published by NISCAIR

[16 journals]

Benzothiazole analogues and their biological aspects: A Review
- Abstract: Title: Benzothiazole analogues and their biological aspects: A Review
  Authors : Popli, Jyoti V; Kumbhare, Manoj R; Surana, Ajay R; Bhalerao, Mrunal R; Agrawal, Pranay A: Heterocyclic compounds analogues have attracted strong interest in medicinal chemistry due to their pharmacological properties. Benzothiazole belongs to the heterocyclic class of bicyclic compounds. It is a combination of two rings six membered and five membered and both the rings are responsible for the therapeutic activity. Different methods are used to synthesize benzothiazole compounds and have been found to have numerous biological activities like – anticancer, antimicrobial, anti-inflammatory, anti-leishmanial, antidiabetic activity. This review is mainly an attempt to present the work reported in literature on pharmacological activity of benzothiazole compounds.Page(s): 1659-1669
  PubDate: 2021-12-01T00:00:00Z
Crystal structure determination, molecular modeling and surface analysis
studies of 2-(4,6-dihydropyren-3-yl)-1H-benzodimidazole
- Abstract: Title: Crystal structure determination, molecular modeling and surface analysis studies of 2-(4,6-dihydropyren-3-yl)-1H-benzodimidazole
  Authors : Manickam, R; Jagan, R; Jagadeesan, G; Srinivasan, G: Benzoimidazole compound has been synthesized and structurally characterized by single crystal X-ray diffraction studies, molecular docking and Hirshfeld surface analysis. The title compound C23 H14 N2 crystallizes in the Orthorhombic crystal system with the crystallographic space group of Pna21 with cell parameters a = 9.4472(5)Å, b=9.0556(5)Å, c=18.3755(11)Å, V=1572.03(15)Å3 and Z=4. The structure exhibits various intra and intermolecular interactions of the type N-H...N. Molecular docking studies of benzoimidazole compound have been executed with Cancer Osaka Thyroid kinease target protein which shows high binding affinity. In addition to this, Hirshfeld surface computational analysis have been carried out to analysis the hydrogen bond interaction. The major intermolecular contacts contributing to the Hirshfeld surface are H...H, H...N and H...C, respectively.Page(s): 1652-1658
  PubDate: 2021-12-01T00:00:00Z
Synthesis, structure elucidation and antibacterial screening of some novel
1,3,4-oxadiazoline derivatives
- Abstract: Title: Synthesis, structure elucidation and antibacterial screening of some novel 1,3,4-oxadiazoline derivatives
  Authors : Arshad, Mohammad; Beg, Md Amjad; Bhat, Abdul R; Athar, Fareeda: Anovel sequence of 1,3,4-oxadiazoline derivatives has been synthesized with an endeavour to explore their consequence on in vitro growth of microbes causing the microbial contagion. In vitro antimicrobial activity has been performed against the Escherichia coli (E. coli) and Proteus mirabilis (P. mirabilis) which are Gram-negative (Gram-ve) and Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermis) which are Gram-positive (Gram+ve) by using disk diffusion method. The minimum inhibitory concentration (MIC) has been distinguished by employing the double dilution method. The result of percent inhibition area/µg of the compounds has been differentiated with the standard drug “Ciprofloxacin”. Several compounds portray excellent activity as compared to the standard drug Ciprofloxacin while some of them presented a considerable zone of inhibition. The evaluated compounds for cytotoxicity effects via Human hepatocellular carcinoma (HepG2) cell line by MTT-assay and findings reveal that the experimental compounds display a viability of ≥80% at 100 µM. In molecular docking studies, the 1,3,4-oxadiazoline derivatives demonstrate the ligandreceptor interaction with amino acids which exist on the active sites of the peptide deformylase and the 1,3,4-oxadiazoline derivatives exhibit their antibacterial potential as peptide deformylase inhibitors.Page(s): 1636-1651
  PubDate: 2021-12-01T00:00:00Z
Synthesis, crystal structure and fluorescence spectrum of some new
1,2,3-triazolxanthen-3-one derivatives
- Abstract: Title: Synthesis, crystal structure and fluorescence spectrum of some new 1,2,3-triazolxanthen-3-one derivatives
  Authors : Dong, Hong-Ru; Jin, Chi-Qiong; Chen, Zi-Bao: Some new compounds 9-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)-6-hydroxy-3H-xanthen-3-one 7a-j have been synthesized for new fluorescence probe material. Their fluorescence and ultraviolet-visible spectra have been studied. Their structures are established by MS, IR and 1H NMR spectral data. The structure of title compound 7c has been identified by X-ray diffraction. C22H14C1N3O3, belongs to triclinic system, space group Pī with a = 8.296(4), b = 9.726(5), c = 11.976(6) Å, α = 90.953(7), β = 105.081(7), γ = 100.693(8)º, V = 914.7(8)Å3, Z = 2, Dc = 1.466 Mg/m3, F(000) = 416.0 and μ = 0.240 mm–1. The title compound has a weaker inhibiting HIV-1 protease than indinavir.Page(s): 1629-1635
  PubDate: 2021-12-01T00:00:00Z