Subjects -> CHEMISTRY (Total: 928 journals)
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CHEMISTRY (661 journals)                  1 2 3 4 | Last

Showing 1 - 200 of 735 Journals sorted alphabetically
Accounts of Materials Research     Hybrid Journal   (Followers: 11)
Accreditation and Quality Assurance: Journal for Quality, Comparability and Reliability in Chemical Measurement     Hybrid Journal   (Followers: 33)
ACS Applied Polymer Materials     Hybrid Journal   (Followers: 18)
ACS Catalysis     Hybrid Journal   (Followers: 61)
ACS Chemical Neuroscience     Hybrid Journal   (Followers: 26)
ACS Combinatorial Science     Hybrid Journal   (Followers: 14)
ACS Environmental Au     Open Access   (Followers: 11)
ACS Macro Letters     Hybrid Journal   (Followers: 29)
ACS Materials Letters     Open Access   (Followers: 10)
ACS Medicinal Chemistry Letters     Hybrid Journal   (Followers: 45)
ACS Nano     Hybrid Journal   (Followers: 235)
ACS Photonics     Hybrid Journal   (Followers: 16)
ACS Symposium Series     Full-text available via subscription   (Followers: 5)
ACS Synthetic Biology     Hybrid Journal   (Followers: 39)
Acta Chemica Malaysia     Open Access   (Followers: 2)
Acta Chimica Slovaca     Open Access   (Followers: 4)
Acta Chimica Slovenica     Open Access   (Followers: 4)
Acta Chromatographica     Full-text available via subscription   (Followers: 9)
Acta Metallurgica Sinica (English Letters)     Hybrid Journal   (Followers: 10)
Acta Scientifica Naturalis     Open Access   (Followers: 4)
adhäsion KLEBEN & DICHTEN     Hybrid Journal   (Followers: 10)
Adhesion Adhesives & Sealants     Hybrid Journal   (Followers: 12)
Adsorption Science & Technology     Open Access   (Followers: 9)
Advanced Electronic Materials     Hybrid Journal   (Followers: 14)
Advanced Functional Materials     Hybrid Journal   (Followers: 78)
Advanced Journal of Chemistry, Section A     Open Access   (Followers: 4)
Advanced Journal of Chemistry, Section B     Open Access   (Followers: 3)
Advanced Science Focus     Free   (Followers: 8)
Advanced Theory and Simulations     Hybrid Journal   (Followers: 5)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Chemical Engineering and Science     Open Access   (Followers: 141)
Advances in Chemical Science     Open Access   (Followers: 52)
Advances in Chemistry     Open Access   (Followers: 40)
Advances in Chemistry     Full-text available via subscription   (Followers: 11)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 15)
Advances in Environmental Chemistry     Open Access   (Followers: 15)
Advances in Enzyme Research     Open Access   (Followers: 10)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8)
Advances in Materials Physics and Chemistry     Open Access   (Followers: 35)
Advances in Nanoparticles     Open Access   (Followers: 17)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Polymer Science     Hybrid Journal   (Followers: 50)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 18)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Sample Preparation     Open Access   (Followers: 5)
Advances in Science and Technology     Full-text available via subscription   (Followers: 18)
Aerosol Science and Engineering     Hybrid Journal   (Followers: 2)
African Journal of Chemical Education     Open Access   (Followers: 7)
African Journal of Pure and Applied Chemistry     Open Access   (Followers: 6)
Aggregate     Open Access   (Followers: 2)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
Al-Kimia : Jurnal Penelitian Sains Kimia     Open Access  
Alchemy : Journal of Chemistry     Open Access   (Followers: 2)
Alchemy : Jurnal Penelitian Kimia     Open Access  
Alfarama Journal of Basic & Applied Sciences     Open Access   (Followers: 12)
Alotrop     Open Access  
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Journal of Biochemistry and Biotechnology     Open Access   (Followers: 45)
American Journal of Biochemistry and Molecular Biology     Open Access   (Followers: 21)
American Journal of Chemistry     Open Access   (Followers: 37)
American Journal of Plant Physiology     Open Access   (Followers: 9)
Analyst     Hybrid Journal   (Followers: 35)
Analytical Science Advances     Open Access   (Followers: 1)
Angewandte Chemie     Hybrid Journal   (Followers: 173)
Angewandte Chemie International Edition     Hybrid Journal   (Followers: 285)
Annales Universitatis Mariae Curie-Sklodowska, sectio AA – Chemia     Open Access   (Followers: 1)
Annals of Clinical Chemistry and Laboratory Medicine     Open Access   (Followers: 6)
Annual Reports in Computational Chemistry     Full-text available via subscription   (Followers: 4)
Annual Reports Section A (Inorganic Chemistry)     Full-text available via subscription   (Followers: 5)
Annual Review of Chemical and Biomolecular Engineering     Full-text available via subscription   (Followers: 14)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 13)
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 1)
Applied Organometallic Chemistry     Hybrid Journal   (Followers: 7)
Applied Spectroscopy     Full-text available via subscription   (Followers: 20)
Applied Surface Science     Hybrid Journal   (Followers: 31)
Arabian Journal of Chemistry     Open Access   (Followers: 4)
ARKIVOC     Open Access   (Followers: 1)
Asian Journal of Applied Chemistry Research     Open Access   (Followers: 1)
Asian Journal of Biochemistry     Open Access   (Followers: 2)
Asian Journal of Chemical Sciences     Open Access   (Followers: 1)
Asian Journal of Chemistry and Pharmaceutical Sciences     Open Access  
Asian Journal of Physical and Chemical Sciences     Open Access   (Followers: 2)
Australian Journal of Chemistry     Hybrid Journal   (Followers: 8)
Autophagy     Hybrid Journal   (Followers: 8)
Biochemical Pharmacology     Hybrid Journal   (Followers: 10)
Biochemistry     Hybrid Journal   (Followers: 257)
Biochemistry Insights     Open Access   (Followers: 6)
Biochemistry Research International     Open Access   (Followers: 5)
BioChip Journal     Hybrid Journal  
Bioinorganic Chemistry and Applications     Open Access   (Followers: 5)
Biointerface Research in Applied Chemistry     Open Access  
Biointerphases     Open Access   (Followers: 1)
Biology, Medicine, & Natural Product Chemistry     Open Access   (Followers: 2)
Biomacromolecules     Hybrid Journal   (Followers: 24)
Biomass Conversion and Biorefinery     Partially Free   (Followers: 10)
Biomedical Chromatography     Hybrid Journal   (Followers: 6)
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 3)
BioNanoScience     Partially Free   (Followers: 3)
Bioorganic & Medicinal Chemistry     Hybrid Journal   (Followers: 86)
Bioorganic & Medicinal Chemistry Letters     Hybrid Journal   (Followers: 61)
Bioorganic Chemistry     Hybrid Journal   (Followers: 7)
Biopolymers     Hybrid Journal   (Followers: 15)
Biosensors     Open Access   (Followers: 3)
Biotechnic and Histochemistry     Hybrid Journal   (Followers: 3)
Bitácora Digital     Open Access  
Boletin de la Sociedad Chilena de Quimica     Open Access  
Bulletin of Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences     Open Access  
Bulletin of the Chemical Society of Ethiopia     Open Access   (Followers: 1)
Bulletin of the Chemical Society of Japan     Full-text available via subscription   (Followers: 25)
Bulletin of the Korean Chemical Society     Hybrid Journal   (Followers: 1)
C - Journal of Carbon Research     Open Access   (Followers: 5)
Cakra Kimia (Indonesian E-Journal of Applied Chemistry)     Open Access  
Canadian Association of Radiologists Journal     Full-text available via subscription   (Followers: 1)
Canadian Journal of Chemistry     Hybrid Journal   (Followers: 11)
Canadian Mineralogist     Full-text available via subscription   (Followers: 5)
Carbohydrate Polymer Technologies and Applications     Open Access   (Followers: 1)
Carbohydrate Polymers     Hybrid Journal   (Followers: 11)
Carbohydrate Research     Hybrid Journal   (Followers: 23)
Carbon     Hybrid Journal   (Followers: 64)
Carbon Capture Science & Technology     Open Access   (Followers: 1)
Carbon Trends     Open Access   (Followers: 6)
Catalysis Reviews: Science and Engineering     Hybrid Journal   (Followers: 9)
Catalysis Science and Technology     Hybrid Journal   (Followers: 10)
Catalysis Surveys from Asia     Hybrid Journal   (Followers: 4)
Catalysts     Open Access   (Followers: 12)
Cell Reports Physical Science     Open Access   (Followers: 1)
Cellulose     Hybrid Journal   (Followers: 8)
Cereal Chemistry     Full-text available via subscription   (Followers: 4)
Chem     Hybrid Journal   (Followers: 8)
Chem Catalysis     Hybrid Journal   (Followers: 2)
ChemBioEng Reviews     Full-text available via subscription   (Followers: 3)
ChemCatChem     Hybrid Journal   (Followers: 8)
Chemical and Engineering News     Free   (Followers: 22)
Chemical Bulletin of Kazakh National University     Open Access  
Chemical Communications     Hybrid Journal   (Followers: 85)
Chemical Engineering Research and Design     Hybrid Journal   (Followers: 27)
Chemical Physics Impact     Full-text available via subscription   (Followers: 1)
Chemical Research in Chinese Universities     Hybrid Journal   (Followers: 4)
Chemical Research in Toxicology     Hybrid Journal   (Followers: 22)
Chemical Reviews     Hybrid Journal   (Followers: 228)
Chemical Science     Open Access   (Followers: 45)
Chemical Science International Journal     Open Access  
Chemical Technology     Open Access   (Followers: 75)
Chemical Thermodynamics and Thermal Analysis     Open Access   (Followers: 4)
Chemical Vapor Deposition     Hybrid Journal   (Followers: 4)
Chemie in Unserer Zeit     Hybrid Journal   (Followers: 39)
Chemie-Ingenieur-Technik (Cit)     Hybrid Journal   (Followers: 18)
ChemInform     Hybrid Journal   (Followers: 5)
Chemistry     Open Access  
Chemistry & Biodiversity     Hybrid Journal   (Followers: 7)
Chemistry & Industry     Full-text available via subscription   (Followers: 6)
Chemistry - A European Journal     Hybrid Journal   (Followers: 154)
Chemistry - An Asian Journal     Hybrid Journal   (Followers: 22)
Chemistry Africa : A Journal of the Tunisian Chemical Society     Hybrid Journal  
Chemistry and Materials Research     Open Access   (Followers: 20)
Chemistry Central Journal     Open Access   (Followers: 4)
Chemistry Education Research and Practice     Free   (Followers: 7)
Chemistry Education Review     Open Access   (Followers: 2)
Chemistry in Education     Open Access   (Followers: 5)
Chemistry Letters     Full-text available via subscription   (Followers: 44)
Chemistry of Heterocyclic Compounds     Hybrid Journal   (Followers: 5)
Chemistry of Materials     Hybrid Journal   (Followers: 195)
Chemistry of Natural Compounds     Hybrid Journal   (Followers: 10)
Chemistry World     Hybrid Journal   (Followers: 20)
Chemistry-Didactics-Ecology-Metrology     Open Access  
ChemistryOpen     Open Access   (Followers: 1)
ChemistrySelect     Hybrid Journal   (Followers: 1)
Chemistry–Methods     Open Access   (Followers: 4)
Chemkon - Chemie Konkret, Forum Fuer Unterricht Und Didaktik     Hybrid Journal  
ChemNanoMat     Hybrid Journal   (Followers: 1)
Chemoecology     Hybrid Journal   (Followers: 2)
Chemometrics and Intelligent Laboratory Systems     Hybrid Journal   (Followers: 13)
Chemosensors     Open Access   (Followers: 1)
ChemPhotoChem     Hybrid Journal  
ChemPhysChem     Hybrid Journal   (Followers: 12)
ChemPhysMater     Full-text available via subscription  
ChemPlusChem     Hybrid Journal   (Followers: 2)
Chempublish Journal     Open Access  
ChemSystemsChem     Hybrid Journal   (Followers: 1)
ChemTexts     Hybrid Journal   (Followers: 1)
CHIMIA International Journal for Chemistry     Open Access   (Followers: 2)
Chinese Journal of Chemistry     Hybrid Journal   (Followers: 6)
Chinese Journal of Polymer Science     Hybrid Journal   (Followers: 9)
Chromatographia     Hybrid Journal   (Followers: 21)
Chromatography     Open Access   (Followers: 3)
Chromatography Research International     Open Access   (Followers: 4)
Ciencia     Open Access  
Clay Minerals     Hybrid Journal   (Followers: 9)
Cogent Chemistry     Open Access   (Followers: 3)
Colloid and Interface Science Communications     Open Access  
Colloid and Polymer Science     Hybrid Journal   (Followers: 7)
Colloids and Interfaces     Open Access  
Colloids and Surfaces B: Biointerfaces     Hybrid Journal   (Followers: 9)
Combinatorial Chemistry & High Throughput Screening     Hybrid Journal   (Followers: 2)
Combustion Science and Technology     Hybrid Journal   (Followers: 26)
Comments on Inorganic Chemistry: A Journal of Critical Discussion of the Current Literature     Hybrid Journal   (Followers: 1)
Communications Chemistry     Open Access   (Followers: 2)
Communications Materials     Open Access  
Composite Interfaces     Hybrid Journal   (Followers: 7)

        1 2 3 4 | Last

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Journal Cover
Biochemistry Insights
Number of Followers: 6  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1178-6264
Published by Sage Publications Homepage  [1176 journals]
  • A Solo Dance or a Tango'

    • Authors: Yulin Wan, Shanshan An, Yanchao Zhou, Man Tang, Qiuyun Liu
      Abstract: Biochemistry Insights, Volume 12, Issue , January-December 2019.
      Previous studies have identified genetic factors and Epstein-Barr virus underlying nasopharyngeal carcinoma. A hypothesis postulated that the local buildup of HCl, mediated by hydrogen bond donors and acceptors and basic amino acids, causes cancer. Nasopharyngeal carcinoma incidences are high in the humid southern coastal China, Southeast Asia, and Mediterranean regions, but not in the noncoastal and nonhumid southern Yunnan Province, China, and nonhumid Central China. The nearly saturated humidity in the Huinan period in Guangdong can trigger the expression of proteins with extensive hydrogen bonding to protons, augmenting the formation of HCl that is mutagenic. Given that the Epstein-Barr virus carries high content of hydrogen bond donors and acceptors, the moist environment in the nasal cavity may enable the virus to colonize the site, compounding pertinent investigations as both virus and high humidity are likely to trigger carcinogenesis. Therefore, the phenomena of exceptionally high humidity in regions with high nasopharyngeal cancer rates warrant further investigations.
      Citation: Biochemistry Insights
      PubDate: 2019-11-13T05:45:52Z
      DOI: 10.1177/1178626419886280
      Issue No: Vol. 12 (2019)
  • Protective Effects of Acridocarpus smeathmannii (DC.) Guill. & Perr. Root
           Extract against Phenylhydrazine-Induced Haematotoxicity, Biochemical
           Changes, and Oxidative Stress in Rats

    • Authors: Oluwafemi Ezekiel Kale, Olufunsho Awodele, Abidemi James Akindele
      Abstract: Biochemistry Insights, Volume 12, Issue , January-December 2019.
      Several strategies for discovering drugs from unexplored natural products continue to strengthen research and development with current commercial evidence supporting their applications. We assessed the effects of the hydroethanolic extract of Acridocarpus smeathmannii root (HEASR) against phenylhydrazine (PHZ)-induced haematotoxicity, biochemical changes, and oxidative stress in male Wistar rats. Groups 1 and 2 controls received normal saline (10 mL/kg/day) and PHZ (60 mg/kg, day 4 and 5), respectively, via oral gavage. Groups 3, 4, and 5 were administered dexamethasone (DXM, 0.014 mg/kg/day, p.o.), HEASR1 (50 mg/kg/day, p.o.) and HEASR2 (200 mg/kg/day, p.o.), respectively. Groups 6, 7, and 8 received HEASR2 (200 mg/kg/day), DXM (0.014 mg/kg/day), or their combination, respectively, and further received PHZ (60 mg/kg/day) intervention on day 4 and 5 only. Treatments lasted for 7 days. Phenylhydrazine toxicity manifested as lowered haemoglobin, white blood cells, lymphocytes, red blood cells, and platelet levels by 45.86%, 53.47%, 75.69%, 46.89%, and 30.29%, respectively, in rats. This was accompanied by an increase in serum alanine (ALT; 108.25%) and aspartate (AST; 78.79%) aminotransferases, urea (84.36%), total cholesterol (81.55%), and triglycerides (123.42%) levels. Similarly, malondialdehyde levels and serum cyclooxygenase-2 activity were elevated (P 
      Citation: Biochemistry Insights
      PubDate: 2019-11-07T05:37:30Z
      DOI: 10.1177/1178626419883243
      Issue No: Vol. 12 (2019)
  • The Roles of N6-Methyladenosine in Human Diseases

    • Authors: Shanshan An, Jiaming Zhang, Yuchuan Wang, Ying Zhang, Qiuyun Liu
      Abstract: Biochemistry Insights, Volume 12, Issue , January-December 2019.
      N 6-Methyladenosine methylations and demethylations are associated with a number of human diseases. A chemical and biochemical perspective can complement the biological view of the epigenetic mechanism. The orbital of imino nitrogen and nitrogen-hydrogen orbital displays p-π conjugation and σ-σ hyperconjugation. The electron delocalization attenuates secondary chemical bonding, resulting in low affinities on the imino nitrogen atom to cations. Reduced proton accumulation via N 6-methyladenosine correlates to lower cellular proton levels which may reflect cell physiology and pathogenesis. The lower affinity of the imino nitrogen to divalent cations in the methylated form versus the nonmethylated form may lead to reduced formation of insoluble and rigid calcium oxalate, which was proposed to be the cause of many diseases. The chemical and biochemical attributes of N 6-methyladenosine crosstalk with biological pathways upregulating and/or downregulating gene expressions to give rise to various physiological and biochemical outcomes at the cellular levels and the organismal levels.
      Citation: Biochemistry Insights
      PubDate: 2019-10-22T10:46:41Z
      DOI: 10.1177/1178626419883248
      Issue No: Vol. 12 (2019)
  • Cellular States and Secondary Chemical Bonding: A Biochemical View of
           Major Human Diseases

    • Authors: Yulin Wan, Jiaming Zhang, Xiaoxia Li, Yuchuan Wang, Qiuyun Liu
      Abstract: Biochemistry Insights, Volume 12, Issue , January-December 2019.
      Nasopharyngeal carcinoma is prevalent in hot and humid areas such as south coastal China and Southeast Asia, but not in the non-coastal southern Chinese Yunnan Province. Secondary chemical bonding may underlie such phenomena. Cancer may be caused by strong acids such as HCl, whereas insoluble and rigid salts such as calcium oxalate are the potential causative factors of heart disease and the Alzheimer disease. The weak organic acids produced by plants counteract strong acids and dissolve insoluble salts, therefore boasting dual roles in disease prevention and treatments. The aforementioned perspective sheds light on the underlying mechanism of human disorders and opens new avenues in the interventions of numerous diseases.
      Citation: Biochemistry Insights
      PubDate: 2019-09-23T11:31:07Z
      DOI: 10.1177/1178626419877846
      Issue No: Vol. 12 (2019)
  • Aerococcus urinae and Globicatella sanguinis Persist in Polymicrobial
           Urethral Catheter Biofilms Examined in Longitudinal Profiles at the
           Proteomic Level

    • Authors: Yanbao Yu, Tamara Tsitrin, Shiferaw Bekele, Vishal Thovarai, Manolito G Torralba, Harinder Singh, Randall Wolcott, Sebastian N Doerfert, Maria V Sizova, Slava S Epstein, Rembert Pieper
      Abstract: Biochemistry Insights, Volume 12, Issue , January-December 2019.
      Aerococcus urinae (Au) and Globicatella sanguinis (Gs) are gram-positive bacteria belonging to the family Aerococcaceae and colonize the human immunocompromised and catheterized urinary tract. We identified both pathogens in polymicrobial urethral catheter biofilms (CBs) with a combination of 16S rDNA sequencing, proteomic analyses, and microbial cultures. Longitudinal sampling of biofilms from serially replaced catheters revealed that each species persisted in the urinary tract of a patient in cohabitation with 1 or more gram-negative uropathogens. The Gs and Au proteomes revealed active glycolytic, heterolactic fermentation, and peptide catabolic energy metabolism pathways in an anaerobic milieu. A few phosphotransferase system (PTS)–based sugar uptake and oligopeptide ABC transport systems were highly expressed, indicating adaptations to the supply of nutrients in urine and from exfoliating squamous epithelial and urothelial cells. Differences in the Au vs Gs metabolisms pertained to citrate lyase and utilization and storage of glycogen (evident only in Gs proteomes) and to the enzyme Xfp that degrades d-xylulose-5′-phosphate and the biosynthetic pathways for 2 protein cofactors, pyridoxal 6′-phosphate and 4′-phosphopantothenate (expressed only in Au proteomes). A predicted ZnuA-like transition metal ion uptake system was identified for Gs while Au expressed 2 LPXTG-anchored surface proteins, one of which had a predicted pilin D adhesion motif. While these proteins may contribute to fitness and virulence in the human host, it cannot be ruled out that Au and Gs fill a niche in polymicrobial biofilms without being the direct cause of injury in urothelial tissues.
      Citation: Biochemistry Insights
      PubDate: 2019-09-19T07:55:39Z
      DOI: 10.1177/1178626419875089
      Issue No: Vol. 12 (2019)
  • A High Creatine Kinase Concentration Might Be a Sign of McArdle Disease in
           Patient With Type 1 Diabetes

    • Authors: Kader Ugur, Yakup Aydogan, Abdurrahman Akgun, Suleyman Aydin
      Abstract: Biochemistry Insights, Volume 12, Issue , January-December 2019.
      Type 1 diabetes (the pancreas producing little or no insulin) is usually diagnosed in children and young adults and was previously known as juvenile diabetes. McArdle disease is a common metabolic defect caused by an inherited deficit of myophosphorylase. These 2 diseases might have some clinical heterogeneity. Here, we discuss a McArdle disease case where insulin-dependent diabetes overshadows its early diagnosis. In this case, an insulin-dependent 22-year-old female patient with diabetes mellitus had been on diabetes treatment for 15 years. Although her blood glucose was regulated, her anamnesis showed that muscle weakness, fatigue, cramps or myalgia never healed. Based on her anamnesis, the patient was asked to take a nonischemic forearm exercise test, which revealed significant elevation in levels of creatine kinase (5968-7906 U/L), but no increase was found in lactate concentration, but a slight increase in ammonia concentration (not statistically significant) at the end of the test made us consider McArdle disease. A genetic test was done to confirm this possibility. A homozygous c.2128_2130delTTC/p.Phe710del mutation was detected in the examination of exons of the PYGM gene, which confirmed the diagnosis of McArdle disease in our patient. According to the data, this is a rare case of McArdle disease with type 1 diabetes. During treatment for diabetes, if the above-mentioned symptoms are present in a patient, and especially if the patient’s creatine kinase concentration is high, muscle diseases should be suspected. Therefore, we suggest that this case report will provide new insight to clinicians on metabolic defects in this disease and increase the patient comfort. In such cases, an early diagnosis should reduce health costs.
      Citation: Biochemistry Insights
      PubDate: 2019-07-15T07:53:22Z
      DOI: 10.1177/1178626419861407
      Issue No: Vol. 12 (2019)
  • The Role of Insulin-Like Growth Factors and Insulin-Like Growth
           Factor–Binding Proteins in the Nervous System

    • Authors: Moira S Lewitt, Gary W Boyd
      Abstract: Biochemistry Insights, Volume 12, Issue , January-December 2019.
      The insulin-like growth factors (IGF-I and IGF-II) and their receptors are widely expressed in nervous tissue from early embryonic life. They also cross the blood brain barriers by active transport, and their regulation as endocrine factors therefore differs from other tissues. In brain, IGFs have paracrine and autocrine actions that are modulated by IGF-binding proteins and interact with other growth factor signalling pathways. The IGF system has roles in nervous system development and maintenance. There is substantial evidence for a specific role for this system in some neurodegenerative diseases, and neuroprotective actions make this system an attractive target for new therapeutic approaches. In developing new therapies, interaction with IGF-binding proteins and other growth factor signalling pathways should be considered. This evidence is reviewed, gaps in knowledge are highlighted, and recommendations are made for future research.
      Citation: Biochemistry Insights
      PubDate: 2019-04-17T11:45:20Z
      DOI: 10.1177/1178626419842176
      Issue No: Vol. 12 (2019)
  • Connexin-43 Enhances the Redesigned Cytosine Deaminase Activity for
           Suicide Gene Therapy in Human Breast Cancer Cells

    • Authors: Asif Raza, Siddhartha Sankar Ghosh
      Abstract: Biochemistry Insights, Volume 12, Issue , January-December 2019.
      Background:Escherichia coli cytosine deaminase (CD) converts 5-fluorocytosine (5-FC), a prodrug, into 5-fluorouracil (5-FU), a chemotherapeutic drug. However, the poor binding affinity of CD towards 5-FC as compared to the natural substrate cytosine, limits its application towards a successful suicide gene therapy. Although F186W mutant was developed to enhance the effect of wild-type CD, still scope for its improvement remains to further minimize the dose-dependent cytotoxicity of the drugs. Hence, in this study, we employ the anti-tumour attribute of the gap junction forming protein connexin-43 (Cx43) in conjunction with CD or F186W mutant.Methods:Lipofectamine was used to co-transfect CD/F186W-pVITRO2 and Cx43-pEGFP-N1 plasmids construct into MCF-7 cells. Comparative analysis of cell viability was observed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium-bromide (MTT) and trypan blue–based assays. To further confirm the mode of cell death was apoptosis, propidium iodide and annexin V/7-aminoactinomycin D (7-AAD)-based apoptosis assays were performed.Results:Semi-quantitative polymerase chain reaction (PCR) confirmed the expression of both Cx43 and CD/F186W genes after transfection. Furthermore, cell viability assays revealed the enhanced activity of F186W-Cx43 compared with CD-Cx43 and F186W alone. The trend of the reduction in cell viability was also reflected in the flow cytometry–based apoptosis analyses. Overall, F186W-Cx43 combination demonstrated its superiority over the CD-Cx43 and F186W mutant alone.Conclusions:The enhanced cytotoxic activity of F186W mutant was further amplified by gap junction protein Cx43.
      Citation: Biochemistry Insights
      PubDate: 2019-01-21T11:46:02Z
      DOI: 10.1177/1178626418818182
      Issue No: Vol. 12 (2019)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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