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- INS volume 31 issue 1 Cover and Front matter
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Pages: 1 - 4
PubDate: 2025-03-31
DOI: 10.1017/S1355617725000074
- Neuropsychiatric symptoms predict rate of change in executive function in
Alzheimer’s disease and related dementias-
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Authors: Goodwin; Grace J., Briley, D.A., Singsank, Katie, Tanner, Denise, Maloy-Robertson, Myjae, John, Samantha E.
Pages: 22 - 31
Abstract: Objective:Neuropsychiatric symptoms (NPS) are considered diagnostic and prognostic indicators of dementia and are attributable to neurodegenerative processes. Little is known about the prognostic value of early NPS on executive functioning (EF) decline in Alzheimer’s disease and related dementias (ADRD). We examined whether baseline NPS predicted the rate of executive function (EF) decline among older adults with ADRD.Method:Older adults (n = 1625) with cognitive impairment were selected from the National Alzheimer’s Coordinating Center database. EF was estimated with a latent factor indicated by scores on Number Span Backward, Letter Fluency, and Trail Making-Part B. A curve of factors (CUFF) latent growth curve model was estimated to examine rate of change over four years. Baseline NPS severity was entered as a predictor in the model to examine its influence on the rate of change in EF over time.Results:The CUFF models exhibited good fit. EF significantly declined over four waves (slope = −.16, p < .001). Initial visit NPS severity predicted decline in EF (slope = .013, p < .001), such that those with greater baseline NPS severity demonstrated a more rapid decline in EF performance over time. Presence of 2 NPS significantly predicted EF decline, and those with medium total NPS severity (NPS score of 2–4) at baseline exhibited a sharper decline in EF.Conclusions:Findings underscore the importance of targeting NPS early across ADRD syndromes to minimize EF decline, offering novel insights into how early NPS treatment may alter cognitive trajectories. We provide an innovative, user-friendly web-based application that may be helpful for personalized treatment planning.
PubDate: 2025-01-16
DOI: 10.1017/S1355617724000730
- Diagnostic accuracy of the Montreal Cognitive Assessment in screening for
cognitive impairment in initially hospitalized COVID-19 patients: Findings
from the prospective multicenter NeNeSCo study-
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Authors: Klinkhammer; Simona, Verwijk, Esmée, Geurtsen, Gert, Duits, Annelien A., Matopoulos, Georgios, Visser-Meily, Johanna M.A., Horn, Janneke, Slooter, Arjen J.C., van Heugten, Caroline M., ,
Pages: 59 - 66
Abstract: Objective:This study aimed to investigate the prevalence and nature of cognitive impairment among severely ill COVID-19 patients and the effectiveness of the Montreal Cognitive Assessment (MoCA) in detecting it.Method:We evaluated cognition in COVID-19 patients hospitalized during the first wave (March to June 2020) from six Dutch hospitals, nine months post-discharge, using a comprehensive multi-domain neuropsychological test battery. Test performance was corrected for sex, age, and education differences and transformed into z-scores. Scores within each cognitive domain were averaged and categorized as average and above (z-score ≥ −0.84), low average (z-score −1.28 to −0.84), below average (z-score −1.65 to −1.28), and exceptionally low (z-score < −1.65). Patients were classified with cognitive impairment if at least one domain’s z-score fell below −1.65. We assessed the MoCA’s accuracy using both the original cutoff (
PubDate: 2025-01-03
DOI: 10.1017/S1355617724000675
- Acknowledgments to JINS Guest Editors and External Reviewers, 2024
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Pages: 86 - 87
PubDate: 2025-03-31
DOI: 10.1017/S1355617725000062
- Marital status, brain health, and cognitive reserve among diverse older
adults-
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Authors: Lee; Ji Hyun, Scambray, Kiana A., Morris, Emily P., Sol, Ketlyne, Palms, Jordan D., Zaheed, Afsara B., Martinez, Michelle N., Schupf, Nicole, Manly, Jennifer J., Brickman, Adam M., Zahodne, Laura B.
Pages: 1 - 10
Abstract: Objective:Being married may protect late-life cognition. Less is known about living arrangement among unmarried adults and mechanisms such as brain health (BH) and cognitive reserve (CR) across race and ethnicity or sex/gender. The current study examines (1) associations between marital status, BH, and CR among diverse older adults and (2) whether one’s living arrangement is linked to BH and CR among unmarried adults.Method:Cross-sectional data come from the Washington Heights-Inwood Columbia Aging Project (N = 778, 41% Hispanic, 33% non-Hispanic Black, 25% non-Hispanic White; 64% women). Magnetic resonance imaging (MRI) markers of BH included cortical thickness in Alzheimer’s disease signature regions and hippocampal, gray matter, and white matter hyperintensity volumes. CR was residual variance in an episodic memory composite after partialing out MRI markers. Exploratory analyses stratified by race and ethnicity and sex/gender and included potential mediators.Results:Marital status was associated with CR, but not BH. Compared to married individuals, those who were previously married (i.e., divorced, widowed, and separated) had lower CR than their married counterparts in the full sample, among White and Hispanic subgroups, and among women. Never married women also had lower CR than married women. These findings were independent of age, education, physical health, and household income. Among never married individuals, living with others was negatively linked to BH.Conclusions:Marriage may protect late-life cognition via CR. Findings also highlight differential effects across race and ethnicity and sex/gender. Marital status could be considered when assessing the risk of cognitive impairment during routine screenings.
PubDate: 2024-11-26
DOI: 10.1017/S1355617724000638
- Time-Based prospective memory predicts insight into functional abilities
among community-dwelling older adults-
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Authors: Gereau Mora; Michelle, DesRuisseaux, Libby A., Suchy, Yana
Pages: 11 - 21
Abstract: Objective:Accurate appraisal of one’s own abilities (i.e., insight) is necessary for appropriate compensatory behaviors and sustained independence during aging. Although insight is often purported to be related to executive functioning (EF), nuanced understanding of the cognitive correlates of insight for functional abilities among nondemented older adults is lacking. Because insight shares neuroanatomic underpinnings with time-based prospective memory (PM), the present study examined the contributions of time-based PM, beyond event-based PM and other potential cognitive confounds (i.e., episodic memory, time estimation, and EF), in predicting insight into one’s own performance on instrumental activities of daily living (IADLs) among community-dwelling older adults.Method:A group of 88 nondemented, community-dwelling older adults completed performance-based measures of time- and event-based PM, episodic memory, time estimation, and EF, as well as IADL tasks followed by self-appraisals of their own IADL performance as indices of insight.Results:Time-based PM was moderately-to-strongly associated with insight, beyond event-based PM, time estimation, and episodic memory [F(1,83) = 11.58, p = .001, ηp2 = .122], as well as beyond EF and demographic covariates [F(1,79) = 10.72, p = .002, ηp2 = .119].Specifically, older adults who performed more poorly on a time-based PM task overestimated the efficiency of their own IADL performance to a greater extent.Conclusions:Findings suggest that nondemented older adults with poorer time-based PM may be more prone to inaccurately appraising their functional abilities and that this vulnerability may not be adequately captured by traditional EF measures.
PubDate: 2024-12-03
DOI: 10.1017/S1355617724000614
- Comparing the predictive validity of four MCI definitions for incident
dementia in demographically diverse community-dwelling individuals:
Results from the Einstein Aging Study (EAS)-
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Authors: Chang; Katherine H., Wang, Cuiling, Qin, Jiyue, Katz, Mindy J., Byrd, Desiree A., Lipton, Richard B., Rabin, Laura A.
Pages: 32 - 41
Abstract: Objective:Research examining (MCI) criteria in diverse and/or health-disparate populations is limited. There is a critical need to investigate the predictive validity for incident dementia of widely used MCI definitions in diverse populations.Method:Eligible participants were non-Hispanic White or Black Bronx community residents, free of dementia at enrollment, with at least one annual follow-up visit after baseline. Participants completed annual neurological and neuropsychological evaluations to determine cognitive status. Dementia was defined based on DSM-IV criteria using case conferences. Cox proportional hazard models assessed predictive validity for incident dementia of four specific MCI definitions (Petersen, Jak/Bondi, number of impaired tests, Global Clinical Ratings) at baseline, controlling for age, sex, education, and race/ethnicity. Time-dependent sensitivity and specificity at 2–7 years for each definition, and Youden’s index were calculated as accuracy measures.Results:Participants (N = 1073) ranged in age from 70 to 100 (mean = 78.4 ± 5.3) years at baseline. The sample was 62.5% female, and educational achievement averaged 13.9 ± 3.5 years. Most participants identified as White (70.0%), though Black participants were well-represented (30.0%). In general, MCI definitions differed in sensitivity and specificity for incident dementia. However, there were no significant differences in Youden’s index for any definition, across all years of follow-up.Conclusions:This work provides an important step toward improving the generalizability of the MCI diagnosis to underrepresented/health-disparate populations. While our findings suggest the studied MCI classifications are comparable, researchers and clinicians may choose to consider one method over another depending on the rationale for evaluation or question of interest.
PubDate: 2024-12-27
DOI: 10.1017/S1355617724000729
- Retest reliability and reliable change of community-dwelling Black/African
American older adults with and without mild cognitive impairment using NIH
Toolbox-Cognition Battery and Cogstate Brief Battery for laptop-
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Authors: Rigby; Taylor, Kavcic, Voyko, Shair, Sarah R., Hill-Jarrett, Tanisha G., Garcia, Sarah, Reader, Jon, Persad, Carol, Bhaumik, Arijit K., Pal, Subhamoy, Hampstead, Benjamin M., Giordani, Bruno
Pages: 42 - 52
Abstract: Objective:With the increased use of computer-based tests in clinical and research settings, assessing retest reliability and reliable change of NIH Toolbox-Cognition Battery (NIHTB-CB) and Cogstate Brief Battery (Cogstate) is essential. Previous studies used mostly White samples, but Black/African Americans (B/AAs) must be included in this research to ensure reliability.Method:Participants were B/AA consensus-confirmed healthy controls (HCs) (n = 49) or mild cognitive impairment (MCI) (n = 34) adults 60–85 years that completed NIHTB-CB and Cogstate for laptop at two timepoints within 4 months. Intraclass correlations, the Bland-Altman method, t-tests, and the Pearson correlation coefficient were used. Cut scores indicating reliable change provided.Results:NIHTB-CB composite reliability ranged from .81 to .93 (95% CIs [.37–.96]). The Fluid Composite demonstrated a significant difference between timepoints and was less consistent than the Crystallized Composite. Subtests were less consistent for MCIs (ICCs = .01–.89, CIs [−1.00–.95]) than for HCs (ICCs = .69–.93, CIs [.46–.92]). A moderate correlation was found for MCIs between timepoints and performance on the Total Composite (r = -.40, p = .03), Fluid Composite (r = -.38, p = .03), and Pattern Comparison Processing Speed (r = -.47, p = .006).On Cogstate, HCs had lower reliability (ICCs = .47–.76, CIs [.05–.86]) than MCIs (ICCs = .65–.89, CIs [.29–.95]). Identification reaction time significantly improved between testing timepoints across samples.Conclusions:The NIHTB-CB and Cogstate for laptop show promise for use in research with B/AAs and were reasonably stable up to 4 months. Still, differences were found between those with MCI and HCs. It is recommended that race and cognitive status be considered when using these measures.
PubDate: 2024-12-20
DOI: 10.1017/S1355617724000444
- Evaluating the factor structure and construct validity of the NIH toolbox
in older adults, with a focus on cognitive normalcy and amnestic mild
cognitive impairment: considerations for diversity, including insights
from persons over 85 years of age and Black older Americans-
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Authors: Rose; Savannah, Gergoire, Allyson, Pal, Subhamoy, Reader, Jonathan, Bhaumik, Arijit, Slotkin, Jerry, Ho, Emily, Nowinski, Cindy J., Persad, Carol C, Maher, Amanda Cook, Weintraub, Sandy, Gershon, Richard, Giordani, Bruno
Pages: 53 - 58
Abstract: Objective:Validated computerized assessments for cognitive functioning are crucial for older individuals and those at risk of cognitive decline. The National Institutes of Health (NIH) Toolbox Cognition Battery (NIHTB-CB) exhibits good construct validity but requires validation in diverse populations and for adults aged 85+. This study uses data from the Assessing Reliable Measurement in Alzheimer’s Disease and cognitive Aging study to explore differences in the factor structure of the NIHTB-CB for adults 85 and older, Black participants versus White participants, and those diagnosed as amnestic Mild Cognitive Impairment (aMCI) vs cognitively normal (CN).Method:Subtests from the NACC UDS-3 and NIHTB-CB were administered to 503 community-dwelling Black and White adults ages 55–99 (367 CN; 136 aMCI). Confirmatory factor analyses were used to investigate the original factor structure of NIHTB-CB that forms the basis for NIHTB-CD Index factor scores.Results:Factor analyses for all participants and some participant subsets (aMCI, White, 85+) substantiated the two anticipated factors (Fluid and Crystallized). However, while Black aMCI participants had the expected two-factor structure, for Black CN participants, the List Sorting Working Memory and Picture Sequence tests loaded on the Crystallized factor.Conclusions:Findings provide psychometric support for the NIHTB-CB. Differences in factor structure between Black CN individuals and Black aMCI individuals suggest potential instability across levels of cognitive impairment. Future research should explore changes in NIHTB-CB across diagnoses in different populations.
PubDate: 2024-12-16
DOI: 10.1017/S1355617724000699
- Determining associations between Big Five personality traits and executive
function in an undergraduate student sample-
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Authors: Quarles; Emma, West, Samuel J., Keen, Larry
Pages: 67 - 74
Abstract: ObjectiveThe present study sought to determine the associations between executive functioning and Big Five personality traits in an undergraduate sample.Method:Participants included 200 undergraduates (73% women), with a mean age of approximately 21 years. Participants completed the Big Five Inventory-44 and a psychological assessment battery, which included the Trail Making Test and the Semantic Fluency Test.Results:Results from multiple regression analyses suggested agreeableness was negatively associated with Semantic Fluency – Animals (β = −0.310, p < 0.001). Moreover, conscientiousness was positively associated with Trail Making Test B-A (β = 0.197, p = 0.016), but negatively associated with Trail Making Test A (β = −0.193, p = 0.017).Conclusions:Overall results identified that executive function association with personality varies by construct. Given conscientiousness’ differential associations within the executive function task performances, future research should examine the conscientious threshold that would result in psychological symptomatology associated with extreme lows and highs in conscientiousness.
PubDate: 2024-12-10
DOI: 10.1017/S135561772400047X
- Differentiating the neurobiological correlates for reading gains in
children with reading difficulties with and without
attention-deficit/hyperactivity disorder using fMRI-
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Authors: Rosch; Keri S., Khashab, Masa, Ghanaiem, Sanad, Farah, Rola, Horowitz-Kraus, Tzipi
Pages: 75 - 85
Abstract: Objective:Reading difficulties (RD) frequently co-occur with attention-deficit/hyperactivity disorder (ADHD), and children with both RD + ADHD often demonstrate greater challenges in reading and executive functions (EF) than those with RD-only.Methods:This study examined the effect of a 4-week EF-based reading intervention on behavioral and neurobiological correlates of EF among 8–12 y.o. English-speaking children with RD + ADHD (n = 19), RD-only (n = 18), and typically developing children (n = 18). Behavioral and resting-state fMRI data were collected from all participants before and after 4 weeks of the EF-based reading computerized program. Group (RD + ADHD, RD-only, typical readers) x Test (pre- and post-intervention) repeated measures ANOVAs were conducted for reading, EF, and brain functional connectivity (FC) measures.Results:Across groups, reading (fluency, comprehension) and EF (inhibition, speed of processing) behavioral performance improved following the intervention. Exploratory subgroup comparisons revealed that children with RD + ADHD, but not RD-only, showed significant gains in reading comprehension, whereas inhibition improved in both RD groups, but not among typical readers. Furthermore, across groups, FC between the frontoparietal (FP) and cingulo-opercular (CO) networks decreased following the intervention. Exploratory subgroup comparisons revealed that children with RD + ADHD, but not RD-only, showed a significant decrease in FC of FP-CO and FP-dorsal attention network.Conclusions:These results support the differential response to an EF-based reading intervention of children with RD with and without comorbid ADHD at brain and behavioral levels.
PubDate: 2024-12-27
DOI: 10.1017/S1355617724000717
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