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  Subjects -> PSYCHOLOGY (Total: 983 journals)
Showing 1 - 174 of 174 Journals sorted alphabetically
Academic Psychiatry and Psychology Journal : APPJ     Open Access   (Followers: 24)
Acta Colombiana de Psicología     Open Access   (Followers: 5)
Acta Comportamentalia     Open Access   (Followers: 1)
Acta de Investigación Psicológica     Open Access   (Followers: 1)
Acta Psychologica     Hybrid Journal   (Followers: 22)
Activités     Open Access   (Followers: 1)
Actualidades en Psicologia     Open Access   (Followers: 2)
Adaptive Human Behavior and Physiology     Hybrid Journal   (Followers: 6)
Addictive Behaviors Reports     Open Access   (Followers: 8)
ADHD Attention Deficit and Hyperactivity Disorders     Hybrid Journal   (Followers: 17)
ADHD Report The     Full-text available via subscription   (Followers: 8)
Adolescent Research Review     Hybrid Journal   (Followers: 3)
Advanced Journal of Professional Practice     Open Access  
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 38)
Advances in Mental Health     Hybrid Journal   (Followers: 82)
Advances in Methods and Practices in Psychological Science     Full-text available via subscription   (Followers: 19)
Advances in Neurodevelopmental Disorders     Hybrid Journal   (Followers: 3)
Advances in Physiotherapy     Hybrid Journal   (Followers: 65)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 31)
Affective Science     Hybrid Journal   (Followers: 3)
African Journal of Cross-Cultural Psychology and Sport Facilitation     Full-text available via subscription   (Followers: 5)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 364)
Aggressive Behavior     Hybrid Journal   (Followers: 16)
Aging Psychology     Open Access   (Followers: 2)
Aging, Neuropsychology, and Cognition     Hybrid Journal   (Followers: 42)
Ajayu Órgano de Difusión Científica del Departamento de Psicología UCBSP     Open Access  
Aletheia     Open Access   (Followers: 1)
American Behavioral Scientist     Hybrid Journal   (Followers: 21)
American Imago     Full-text available via subscription   (Followers: 4)
American Journal of Applied Psychology     Open Access   (Followers: 48)
American Journal of Community Psychology     Hybrid Journal   (Followers: 29)
American Journal of Health Behavior     Full-text available via subscription   (Followers: 23)
American Journal of Orthopsychiatry     Hybrid Journal   (Followers: 6)
American Journal of Psychoanalysis     Hybrid Journal   (Followers: 16)
American Journal of Psychology     Full-text available via subscription   (Followers: 43)
American Psychologist     Full-text available via subscription   (Followers: 190)
An-Nafs : Jurnal Fakultas Psikologi     Open Access  
Anales de Psicología / Annals of Psychology     Open Access   (Followers: 2)
Análise Psicológica     Open Access  
Analitika : Jurnal Magister Psikologi Uma     Open Access  
Analogías del Comportamiento     Open Access  
Analysis     Full-text available via subscription   (Followers: 2)
Annual Review of Clinical Psychology     Full-text available via subscription   (Followers: 84)
Annual Review of Organizational Psychology and Organizational Behavior     Full-text available via subscription   (Followers: 49)
Annual Review of Psychology     Full-text available via subscription   (Followers: 268)
Anuario de investigaciones (Facultad de Psicología. Universidad de Buenos Aires)     Open Access   (Followers: 1)
Anuario de Investigaciones de la Facultad de Psicología     Open Access  
Anuario de Psicología / The UB Journal of Psychology     Open Access   (Followers: 1)
Anuario de Psicología Jurídica     Open Access   (Followers: 1)
Anxiety, Stress & Coping: An International Journal     Hybrid Journal   (Followers: 19)
Applied Cognitive Psychology     Hybrid Journal   (Followers: 66)
Applied Neuropsychology : Adult     Hybrid Journal   (Followers: 47)
Applied Neuropsychology : Child     Hybrid Journal   (Followers: 27)
Applied Psycholinguistics     Hybrid Journal   (Followers: 26)
Applied Psychological Measurement     Hybrid Journal   (Followers: 18)
Applied Psychology     Hybrid Journal   (Followers: 155)
Applied Psychology: Health and Well-Being     Hybrid Journal   (Followers: 57)
Applied Psychophysiology and Biofeedback     Hybrid Journal   (Followers: 7)
Aprender     Open Access  
Archives of Clinical Neuropsychology     Hybrid Journal   (Followers: 33)
Archives of Depression and Anxiety     Open Access   (Followers: 1)
Archives of Scientific Psychology     Open Access   (Followers: 6)
Archives of Suicide Research     Hybrid Journal   (Followers: 11)
Arquivos Brasileiros de Psicologia     Open Access   (Followers: 1)
Art Therapy Online     Open Access   (Followers: 3)
Asia Pacific Journal of Counselling and Psychotherapy     Hybrid Journal   (Followers: 7)
Asia-Pacific Psychiatry     Hybrid Journal   (Followers: 5)
Asian American Journal of Psychology     Full-text available via subscription   (Followers: 7)
Asian Journal of Behavioural Studies     Open Access   (Followers: 3)
Asian Journal of Business Ethics     Hybrid Journal   (Followers: 9)
Assessment     Hybrid Journal   (Followers: 17)
Attachment: New Directions in Psychotherapy and Relational Psychoanalysis     Full-text available via subscription   (Followers: 13)
Attention, Perception & Psychophysics     Full-text available via subscription   (Followers: 15)
Augmented Human Research     Hybrid Journal   (Followers: 1)
Australian and Aotearoa New Zealand Psychodrama Association Journal     Full-text available via subscription   (Followers: 4)
Australian Journal of Psychology     Hybrid Journal   (Followers: 26)
Australian Psychologist     Hybrid Journal   (Followers: 14)
Autism Research     Hybrid Journal   (Followers: 45)
Autism Research and Treatment     Open Access   (Followers: 30)
Autism's Own     Open Access   (Followers: 11)
Avaliação Psicológica     Open Access  
Avances en Psicologia Latinoamericana     Open Access  
Aviation Psychology and Applied Human Factors     Hybrid Journal   (Followers: 27)
Balint Journal     Hybrid Journal   (Followers: 3)
Barbaroi     Open Access  
Basic and Applied Social Psychology     Hybrid Journal   (Followers: 39)
Behavior Analysis in Practice     Full-text available via subscription   (Followers: 15)
Behavior Analysis: Research and Practice     Full-text available via subscription   (Followers: 7)
Behavior Analyst     Hybrid Journal   (Followers: 6)
Behavior and Social Issues     Full-text available via subscription   (Followers: 1)
Behavior Modification     Hybrid Journal   (Followers: 13)
Behavior Research Methods     Hybrid Journal   (Followers: 26)
Behavior Therapy     Hybrid Journal   (Followers: 54)
Behavioral Development Bulletin     Full-text available via subscription   (Followers: 1)
Behavioral Disorders     Hybrid Journal   (Followers: 1)
Behavioral Interventions     Hybrid Journal   (Followers: 17)
Behavioral Neuroscience     Full-text available via subscription   (Followers: 63)
Behavioral Sciences & the Law     Hybrid Journal   (Followers: 29)
Behavioral Sleep Medicine     Hybrid Journal   (Followers: 12)
Behaviormetrika     Hybrid Journal  
Behaviour     Hybrid Journal   (Followers: 8)
Behaviour Change     Full-text available via subscription   (Followers: 11)
Behaviour Research and Therapy     Hybrid Journal   (Followers: 22)
Behavioural and Cognitive Psychotherapy     Hybrid Journal   (Followers: 128)
Behavioural Processes     Hybrid Journal   (Followers: 7)
Behavioural Public Policy     Hybrid Journal   (Followers: 3)
Behavioural Sciences Undergraduate Journal     Open Access   (Followers: 1)
Beyond Behavior     Hybrid Journal   (Followers: 2)
BioPsychoSocial Medicine     Open Access   (Followers: 8)
BMC Psychology     Open Access   (Followers: 20)
Body, Movement and Dance in Psychotherapy: An International Journal for Theory, Research and Practice     Hybrid Journal   (Followers: 13)
Boletim Academia Paulista de Psicologia     Open Access  
Boletim de Psicologia     Open Access  
Brain Informatics     Open Access   (Followers: 1)
Brain Science Advances     Open Access  
British Journal of Clinical Psychology     Full-text available via subscription   (Followers: 159)
British Journal of Developmental Psychology     Hybrid Journal   (Followers: 38)
British Journal of Educational Psychology     Hybrid Journal   (Followers: 37)
British Journal of Health Psychology     Hybrid Journal   (Followers: 49)
British Journal of Mathematical and Statistical Psychology     Full-text available via subscription   (Followers: 18)
British Journal of Psychology     Full-text available via subscription   (Followers: 75)
British Journal of Psychotherapy     Hybrid Journal   (Followers: 70)
British Journal of Social Psychology     Full-text available via subscription   (Followers: 45)
Buletin Psikologi     Open Access  
Cadernos de psicanálise (Rio de Janeiro)     Open Access   (Followers: 1)
Cadernos de Psicologia Social do Trabalho     Open Access   (Followers: 1)
Canadian Art Therapy Association     Hybrid Journal  
Canadian Journal of Art Therapy : Research, Practice, and Issues     Hybrid Journal  
Canadian Journal of Behavioural Science     Full-text available via subscription   (Followers: 7)
Canadian Journal of Experimental Psychology     Full-text available via subscription   (Followers: 17)
Canadian Psychology / Psychologie canadienne     Full-text available via subscription   (Followers: 11)
Case Studies in Sport and Exercise Psychology     Hybrid Journal   (Followers: 7)
Castalia : Revista de Psicología de la Academia     Open Access  
CASUS : Revista de Investigación y Casos en Salud     Open Access  
Cendekia : Jurnal Kependidikan dan Kemasyarakatan     Open Access  
CES Psicología     Open Access  
Child Development Perspectives     Hybrid Journal   (Followers: 37)
Child Development Research     Open Access   (Followers: 22)
Ciencia Cognitiva     Open Access   (Followers: 1)
Ciencia e Interculturalidad     Open Access   (Followers: 1)
Ciências & Cognição     Open Access  
Ciencias Psicológicas     Open Access  
Clínica y Salud     Open Access  
Clinical Medicine Insights : Psychiatry     Open Access   (Followers: 9)
Clinical Practice & Epidemiology in Mental Health     Open Access   (Followers: 3)
Clinical Practice in Pediatric Psychology     Full-text available via subscription   (Followers: 13)
Clinical Psychological Science     Hybrid Journal   (Followers: 16)
Clinical Psychologist     Hybrid Journal   (Followers: 22)
Clinical Psychology & Psychotherapy     Hybrid Journal   (Followers: 87)
Clinical Psychology and Special Education     Open Access   (Followers: 7)
Clinical Psychology Review     Hybrid Journal   (Followers: 55)
Clinical Psychology: Science and Practice     Hybrid Journal   (Followers: 29)
Clocks & Sleep     Open Access   (Followers: 1)
Coaching : Theorie & Praxis     Open Access   (Followers: 3)
Coaching Psykologi : The Danish Journal of Coaching Psychology     Open Access   (Followers: 3)
Cogent Psychology     Open Access  
Cógito     Open Access  
Cognition & Emotion     Hybrid Journal   (Followers: 43)
Cognitive Behaviour Therapist     Hybrid Journal   (Followers: 12)
Cognitive Behaviour Therapy     Hybrid Journal   (Followers: 20)
Cognitive Neuropsychology     Hybrid Journal   (Followers: 42)
Cognitive Psychology     Hybrid Journal   (Followers: 75)
Cognitive Research : Principles and Implications     Open Access   (Followers: 5)
Community Psychology in Global Perspective     Open Access   (Followers: 1)
Comprehensive Psychoneuroendocrinology     Open Access  
Comprehensive Results in Social Psychology     Hybrid Journal  
Consciousness and Cognition     Hybrid Journal   (Followers: 37)
Construção Psicopedagógica     Open Access  
Consulting Psychology Journal : Practice and Research     Full-text available via subscription   (Followers: 3)
Consumer Psychology Review     Hybrid Journal   (Followers: 3)
Contagion : Journal of Violence, Mimesis, and Culture     Full-text available via subscription   (Followers: 6)
Contemporary Educational Psychology     Hybrid Journal   (Followers: 29)
Contemporary Psychoanalysis     Hybrid Journal   (Followers: 1)
Contemporary School Psychology     Hybrid Journal   (Followers: 6)
Contextos Clínicos     Open Access  
Counseling et spiritualité / Counselling and Spirituality     Full-text available via subscription   (Followers: 1)
Counseling Outcome Research and Evaluation     Hybrid Journal   (Followers: 12)
Counseling Psychologist     Hybrid Journal   (Followers: 17)
Counseling Psychology and Psychotherapy     Open Access   (Followers: 19)
Counselling and Psychotherapy Research : Linking research with practice     Hybrid Journal   (Followers: 23)
Counselling and Values     Hybrid Journal   (Followers: 5)
Counselling Psychology Quarterly     Hybrid Journal   (Followers: 13)
Couple and Family Psychoanalysis     Full-text available via subscription   (Followers: 2)
Couple and Family Psychology : Research and Practice     Full-text available via subscription   (Followers: 9)
Creativity Research Journal     Hybrid Journal   (Followers: 24)
Creativity. Theories ? Research ? Applications     Open Access   (Followers: 6)
Crime Psychology Review     Hybrid Journal   (Followers: 2)
Criminal Justice Ethics     Hybrid Journal   (Followers: 10)
Cuadernos de Marte     Open Access  
Cuadernos de Neuropsicología     Open Access   (Followers: 1)
Cuadernos de Psicologia del Deporte     Open Access  
Cuadernos Hispanoamericanos de Psicología     Open Access  
cultura & psyché : Journal of Cultural Psychology     Hybrid Journal   (Followers: 1)
Cultural Diversity and Ethnic Minority Psychology     Full-text available via subscription   (Followers: 18)
Cultural-Historical Psychology     Open Access   (Followers: 4)
Culture - Society - Education     Open Access   (Followers: 2)
Culture and Brain     Hybrid Journal   (Followers: 6)
Current Addiction Reports     Hybrid Journal   (Followers: 13)
Current Behavioral Neuroscience Reports     Hybrid Journal   (Followers: 4)
Current Directions In Psychological Science     Hybrid Journal   (Followers: 73)

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Similar Journals
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Clocks & Sleep
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2624-5175
Published by MDPI Homepage  [84 journals]
  • Clocks & Sleep, Vol. 4, Pages 208-218: Direct Effects of Light on Sleep
           under Ultradian Light-Dark Cycles Depend on Circadian Time and Pulses

    • Authors: Fanny Fuchs, Ludivine Robin-Choteau, Laurence Hugueny, Dominique Ciocca, Patrice Bourgin
      First page: 208
      Abstract: Ultradian light–dark cycles in rodents are a precious tool to study the direct effects of repeated light exposures on sleep, in order to better understand the underlying mechanisms. This study aims to precisely evaluate the effects of light and dark exposures, according to circadian time, on sleep and waking distribution and quality, and to determine if these effects depend on the duration of light and dark pulses. To do this, mice were exposed to 24 h-long ultradian light–dark cycles with different durations of pulses: T2 cycle (1 h of light/1 h of dark) and T7 cycle (3.5 h of light/3.5 h of dark). Exposure to light not only promotes NREM and REM sleep and inhibits wake, but also drastically alters alertness and modifies sleep depth. These effects are modulated by circadian time, appearing especially during early subjective night, and their kinetics is highly dependent on the duration of pulses, suggesting that in the case of pulses of longer duration, the homeostatic process could overtake light direct influence for shaping sleep and waking distribution.
      Citation: Clocks & Sleep
      PubDate: 2022-03-24
      DOI: 10.3390/clockssleep4020019
      Issue No: Vol. 4, No. 2 (2022)
  • Clocks & Sleep, Vol. 4, Pages 219-229: Respiratory Muscle Training in
           Patients with Obstructive Sleep Apnoea: A Systematic Review and

    • Authors: Rodrigo Torres-Castro, Lilian Solis-Navarro, Homero Puppo, Victoria Alcaraz-Serrano, Luis Vasconcello-Castillo, Jordi Vilaró, Roberto Vera-Uribe
      First page: 219
      Abstract: Background: Effective treatments for obstructive sleep apnoea (OSA) include positive pressure, weight loss, oral appliances, surgery, and exercise. Although the involvement of the respiratory muscles in OSA is evident, the effect of training them to improve clinical outcomes is not clear. We aimed to determine the effects of respiratory muscle training in patients with OSA. Methods: A systematic review was conducted in seven databases. Studies that applied respiratory muscle training in OSA patients were reviewed. Two independent reviewers analysed the studies, extracted the data and assessed the quality of evidence. Results: Of the 405 reports returned by the initial search, eight articles reporting on 210 patients were included in the data synthesis. Seven included inspiratory muscle training (IMT), and one included expiratory muscle training (EMT). Regarding IMT, we found significant improvement in Epworth sleepiness scale in −4.45 points (95%CI −7.64 to −1.27 points, p = 0.006), in Pittsburgh sleep quality index of −2.79 points (95%CI −4.19 to −1.39 points, p < 0.0001), and maximum inspiratory pressure of −29.56 cmH2O (95%CI −53.14 to −5.98 cmH2O, p = 0.01). However, the apnoea/hypopnea index and physical capacity did not show changes. We did not perform a meta-analysis of EMT due to insufficient studies. Conclusion: IMT improves sleepiness, sleep quality and inspiratory strength in patients with OSA.
      Citation: Clocks & Sleep
      PubDate: 2022-04-11
      DOI: 10.3390/clockssleep4020020
      Issue No: Vol. 4, No. 2 (2022)
  • Clocks & Sleep, Vol. 4, Pages 230-239: Combining Wake-Up-Back-to-Bed with
           Cognitive Induction Techniques: Does Earlier Sleep Interruption Reduce
           Lucid Dream Induction Rate'

    • Authors: Daniel Erlacher, Vitus Furrer, Matthias Ineichen, John Braillard, Daniel Schmid
      First page: 230
      Abstract: Lucid dreaming offers the chance to investigate dreams from within a dream and by real-time dialogue between experimenters and dreamers during REM sleep. This state of consciousness opens a new experimental venue for dream research. However, laboratory study in this field is limited due to the rarity of lucid dreamers. In a previous study, we were able to induce in 50% of the participants a lucid dream in a single sleep laboratory night by combining a wake-up-back-to-bed (WBTB) sleep routine and a mnemonic method (Mnemonic Induction of Lucid Dreams, MILD). In three experiments, we tried to replicate our earlier findings while we adapted our procedure in shortening (Exp1–3: 4.5 vs. 6 h of uninterrupted sleep in the first half of the night), simplifying (Exp2: time-based wakening vs. REM wakening in the second half of the night), and applying another induction technique (Exp3: reality testing vs. MILD). In the three conditions, four out of 15 (26%), zero out of 20 (0%), and three out of 15 (20%) participants reported a lucid dream. Compared to the original study, the earlier sleep interruption seems to reduce the lucid dream induction rate. Furthermore, without REM awakenings in the morning, lucid dream induction failed, whereas reality testing showed a lower success rate compared to MILD. Further systematic sleep laboratory studies are needed to develop reliable techniques for lucid dream research.
      Citation: Clocks & Sleep
      PubDate: 2022-04-20
      DOI: 10.3390/clockssleep4020021
      Issue No: Vol. 4, No. 2 (2022)
  • Clocks & Sleep, Vol. 4, Pages 240-259: Socioeconomic Position and
           Excessive Daytime Sleepiness: A Systematic Review of Social
           Epidemiological Studies

    • Authors: Imene Bendaoud, Faustin Armel Etindele Sosso
      First page: 240
      Abstract: The objectives of this empirical study are to describe and discuss the current literature available on the relationship between excessive daytime sleepiness (EDS) and the socioeconomic position (SEP) as well as to provide recommendations for consideration of SEP in sleep medicine and biomedical research. Databases Medline/PubMed, Web of Science, Google scholar and Scopus were screened from January 1990 to December 2020 using PRISMA guidelines and 20 articles were included in the final synthesis. Nineteen studies were cross-sectional and one study was longitudinal. Among these studies, 25.00% (n = 5) are focused on children and adolescent and the remaining 75.00% (n = 15) focused on adults and seniors. Ages ranged from 8 to 18 years old for children/adolescent and ranged from 18 to 102 years old for adults. Main SEP measures presented in these studies were education, income, perceived socioeconomic status and employment. The sample size in these studies varied from N = 90 participants to N = 33,865 participants. Overall, a lower educational level, a lower income and full-time employment were associated with EDS. Symptoms of EDS are prevalent in women, especially those with a low income or no job; and children and adolescents with difficult living conditions or working part time reported more sleep disturbances. SEP is already considered as an important determinant for many health outcomes, but if SEP is embedded in the experimental design in psychosomatic research, biomedical research and clinical practice as a constant variable regardless of outcome; it will move forward future investigations.
      Citation: Clocks & Sleep
      PubDate: 2022-05-16
      DOI: 10.3390/clockssleep4020022
      Issue No: Vol. 4, No. 2 (2022)
  • Clocks & Sleep, Vol. 4, Pages 260-276: Long-Term Effect of a Single Dose
           of Caffeine on Sleep, the Sleep EEG and Neuronal Activity in the
           Peduncular Part of the Lateral Hypothalamus under Constant Dark Conditions

    • Authors: Yumeng Wang, Tom Deboer
      First page: 260
      Abstract: Background: Caffeine is a central nervous system stimulant that influences both the sleep–wake cycle and the circadian clock and is known to influence neuronal activity in the lateral hypothalamus, an important area involved in sleep–wake regulation. Light is a strong zeitgeber and it is known to interact with the effect of caffeine on the sleep–wake cycle. We therefore wanted to investigate the long-term effects of a single dose of caffeine under constant dark conditions. Methods: We performed long-term (2 days) electroencephalogram (EEG)/electromyogram recordings combined with multi-unit neuronal activity recordings in the peduncular part of the lateral hypothalamus (PLH) under constant darkness in Brown Norway rats, and investigated the effect of a single caffeine treatment (15 mg/kg) or saline control given 1 h after the onset of the endogenous rest phase. Results: After a reduction in sleep and an increase in waking and activity in the first hours after administration, also on the second recording day after caffeine administration, rapid eye movement (REM) sleep was still reduced. Analysis of the EEG showed that power density in the theta range during waking and REM sleep was increased for at least two days. Neuronal activity in PLH was also increased for two days after the treatment, particularly during non-rapid eye movement sleep. Conclusion: Surprisingly, the data reveal long-term effects of a single dose of caffeine on vigilance states, EEG, and neuronal activity in the PLH. The absence of a light–dark cycle may have enabled the expression of these long-term changes. It therefore may be that caffeine, or its metabolites, have a stronger and longer lasting influence, particularly on the expression of REM sleep, than acknowledged until now.
      Citation: Clocks & Sleep
      PubDate: 2022-05-25
      DOI: 10.3390/clockssleep4020023
      Issue No: Vol. 4, No. 2 (2022)
  • Clocks & Sleep, Vol. 4, Pages 277-286: Effect of Modified
           Yukmijihwang-Tang on Sleep Quality in the Rat

    • Authors: SunYoung Lee, Hun-Soo Lee, Minsook Ye, Min-A Kim, Hwajung Kang, Sung Ja Rhie, Mi Young Lee, In Chul Jung, In-Cheol Kang, Insop Shim
      First page: 277
      Abstract: Many plants have been used in Korean medicine for treating insomnia. However, scientific evidence for their sedative activity has not been fully investigated. Thus, this study was carried out to investigate the sedative effects of the extracts of medicinal plants, including Yukmijihwang-tang and its various modified forms through the 5-HT2c receptor binding assay, and to further confirm its sleep-promoting effects and the underlying neural mechanism in rats utilizing electroencephalography (EEG) analysis. Enzyme-linked immunosorbent assay (ELISA) was used to measure serotonin (5-HT) in the brain. The water extracts of modified Yukmijihwang-tang (YmP) displayed binding affinity to the 5-HT2C receptor (IC50 value of 199.9 µg/mL). YmP (50 mg/kg) administration decreased wake time and increased REM and NREM sleep based on EEG data in rats. Additionally, treatment with YmP significantly increased the 5-HT level in the hypothalamus. In conclusion, the sedative effect of YmP can be attributed to the activation of the central serotonergic systems, as evidenced by the high affinity of binding of the 5-HT2C receptor and increased 5-HT levels in the brain of the rat. This study suggests that YmP can be a new material as a sleep inducer in natural products.
      Citation: Clocks & Sleep
      PubDate: 2022-05-27
      DOI: 10.3390/clockssleep4020024
      Issue No: Vol. 4, No. 2 (2022)
  • Clocks & Sleep, Vol. 4, Pages 287-299: Neuroimaging in the Rare Sleep
           Disorder of Kleine–Levin Syndrome: A Systematic Review

    • Authors: Juan Fernando Ortiz, Jennifer M. Argudo, Mario Yépez, Juan Andrés Moncayo, Hyder Tamton, Alex S. Aguirre, Ghanshyam Patel, Meghdeep Sen, Ayushi Mistry, Ray Yuen, Ahmed Aeissa Garces, Diego Ojeda, Samir Ruxmohan
      First page: 287
      Abstract: Kleine–Levin syndrome (KLS) is characterized by episodes of hypersomnia. Additionally, these patients can present with hyperphagia, hypersexuality, abnormal behavior, and cognitive dysfunction. Functional neuroimaging studies such as fMRI-BOLD, Positron Emission Tomography (PET) or SPECT help us understand the neuropathological bases of different disorders. We conducted a systematic review to investigate the neuroimaging features of KLS patients and their clinical correlations. This systematic review was conducted by following the Meta-Analysis of Observational Studies in Epidemiology (MOOSE) and PRISMA protocol reporting guidelines. We aim to investigate the clinical correlation with neuroimaging among patients with KLS. We included only studies written in the English language in the last 20 years, conducted on humans; 10 studies were included. We excluded systematic reviews, metanalysis, and case reports. We found that there are changes in functional imaging studies during the symptomatic and asymptomatic periods as well as in between episodes in patients with K.L.S. The areas most reported as affected were the hypothalamic and thalamic regions, which showed hypoperfusion and, in a few cases, hyperperfusion; areas such as the frontal, parietal, occipital and the prefrontal cortex all showed alterations in cerebral perfusion. These changes in cerebral blood flow and regions vary according to the imaging (SPECT, PET SCAN, or fMRI) and the task performed while imaging was performed. We encountered conflicting data between studies. Hyper insomnia, the main feature of this disease during the symptomatic periods, was associated with decreased thalamic activity. Other features of K.L.S., such as apathy, hypersexuality, and depersonalization, were also correlated with functional imaging changes. There were also findings that correlated with working memory deficits seen in this stage during the asymptomatic periods. Hyperactivity of the thalamus and hypothalamus were the main features shown during the asymptomatic period. Additionally, functional imaging tends to improve with a longer course of the disease, which suggests that K.L.S. patients outgrow the disease. These findings should caution physicians when analyzing and correlating neuroimaging findings with the disease.
      Citation: Clocks & Sleep
      PubDate: 2022-05-31
      DOI: 10.3390/clockssleep4020025
      Issue No: Vol. 4, No. 2 (2022)
  • Clocks & Sleep, Vol. 4, Pages 300-320: 2021 Annual Meeting of the Swiss
           Society for Sleep Research, Sleep Medicine, and Chronobiology (SSSSC)

    • Authors: Martin Hatzinger
      First page: 300
      Abstract: The 2021 meeting in Solothurn provided evidence-based education to advance the science and clinical practice of sleep medicine and sleep physiology, disseminates cutting-edge sleep and circadian research, promotes the translation of basic science into clinical practice, and fosters the future of the field by allowing young clinicians and researchers to present their findings in talks and on posters [...]
      Citation: Clocks & Sleep
      PubDate: 2022-06-07
      DOI: 10.3390/clockssleep4020026
      Issue No: Vol. 4, No. 2 (2022)
  • Clocks & Sleep, Vol. 4, Pages 8: Acknowledgment to Reviewers of Clocks
           & Sleep in 2021

    • Authors: Clocks & Sleep Editorial Office Clocks & Sleep Editorial Office
      First page: 8
      Abstract: Rigorous peer-reviews are the basis of high-quality academic publishing [...]
      Citation: Clocks & Sleep
      PubDate: 2022-01-27
      DOI: 10.3390/clockssleep4010002
      Issue No: Vol. 4, No. 1 (2022)
  • Clocks & Sleep, Vol. 4, Pages 9-15: Dream Recall/Affect and Cortisol:
           An Exploratory Study

    • Authors: Alexandros S. Triantafyllou, Ioannis Ilias, Nicholas-Tiberio Economou, Athina Pappa, Eftychia Koukkou, Paschalis Steiropoulos
      First page: 9
      Abstract: The effect of cortisol on dreams has been scarcely studied. The aim of this exploratory study was to assess the possible effect of cortisol levels on dream recall/affect, considering, in female subjects, their menstrual cycle phase. Fifteen men and fifteen women were recruited. Saliva samples were used for the detection of cortisol levels. Participants were instructed to provide four saliva samples, during three consecutive days. After awakening, on the second and third day, they were asked whether they could recall the previous night’s dreams and whether these were pleasant or unpleasant. Female subjects followed this procedure twice: firstly, during the luteal phase and, secondly, during the follicular phase of the menstrual cycle. Subjects with higher evening or higher morning cortisol levels tended to show increased dream recall; a non-statistically significant association between morning cortisol levels and positive dream affect was also found. This association acquired statistical significance for salivary morning cortisol levels exceeding the upper normal level of 19.1 nmol/L (OR: 4.444, 95% CI: 1.108–17.830, p-value: 0.039). No connection between menstrual cycle stages and dream recall/affect was detected. In conclusion, cortisol may be a crucial neuromodulator, affecting dream recall and content. Therefore, its effects on sleep and dreams should be further studied.
      Citation: Clocks & Sleep
      PubDate: 2022-01-29
      DOI: 10.3390/clockssleep4010003
      Issue No: Vol. 4, No. 1 (2022)
  • Clocks & Sleep, Vol. 4, Pages 16-22: Cross Sectional Study of the
           Community Self-Reported Risk of Obstructive Sleep Apnoea (OSA) and
           Awareness in Thessaly, Greece

    • Authors: Petros Kassas, Georgios D. Vavougios, Chrissi Hatzoglou, Konstantinos I. Gourgoulianis, Sotirios G. Zarogiannis
      First page: 16
      Abstract: The purpose of this study was to investigate the self-reported risk of obstructive sleep apnea syndrome (OSAS) in the municipality of Thessaly, Greece, and the level of awareness of both the disease and its diagnosis. Inhabitants of Thessaly (254 total; 84 men and 170 women) were studied by means of questionnaires via a telephone-randomized survey. This comprised: (a) the Berlin questionnaire for evaluation of OSAS risk; (b) the evaluation of daytime sleepiness by the Epworth Sleepiness Scale; and (c) demographic and anthropometric data. The percentage of participants at high risk for OSA was 26.77%, and the percentage of people who were at high risk of excessive daytime sleepiness was 10.63%. High risk for OSAS was found to be 3.94%. No significant differences were found between high- and low-risk OSAS participants associated with age, smoking and severity of smoking. Regarding the knowledge of the community about OSAS, the majority of the sample was aware of the entity (64.17%), while fewer had knowledge about the diagnosis (18.50%) and polysomnography (24.80%). The high risk of OSA prevalence and the low awareness of the diagnosis of OSA highlights the need for the development of health promotion programs aiming at increasing the disease awareness in the general population in order to address OSA more effectively.
      Citation: Clocks & Sleep
      PubDate: 2022-02-10
      DOI: 10.3390/clockssleep4010004
      Issue No: Vol. 4, No. 1 (2022)
  • Clocks & Sleep, Vol. 4, Pages 23-36: Working around the Clock: Is a
           Person’s Endogenous Circadian Timing for Optimal Neurobehavioral
           Functioning Inherently Task-Dependent'

    • Authors: Rachael A. Muck, Amanda N. Hudson, Kimberly A. Honn, Shobhan Gaddameedhi, Hans P. A. Van Dongen
      First page: 23
      Abstract: Neurobehavioral task performance is modulated by the circadian and homeostatic processes of sleep/wake regulation. Biomathematical modeling of the temporal dynamics of these processes and their interaction allows for prospective prediction of performance impairment in shift-workers and provides a basis for fatigue risk management in 24/7 operations. It has been reported, however, that the impact of the circadian rhythm—and in particular its timing—is inherently task-dependent, which would have profound implications for our understanding of the temporal dynamics of neurobehavioral functioning and the accuracy of biomathematical model predictions. We investigated this issue in a laboratory study designed to unambiguously dissociate the influences of the circadian and homeostatic processes on neurobehavioral performance, as measured during a constant routine protocol preceded by three days on either a simulated night shift or a simulated day shift schedule. Neurobehavioral functions were measured every 2 h using three functionally distinct assays: a digit symbol substitution test, a psychomotor vigilance test, and the Karolinska Sleepiness Scale. After dissociating the circadian and homeostatic influences and accounting for inter-individual variability, peak circadian performance occurred in the late biological afternoon (in the “wake maintenance zone”) for all three neurobehavioral assays. Our results are incongruent with the idea of inherent task-dependent differences in the endogenous circadian impact on performance. Rather, our results suggest that neurobehavioral functions are under top-down circadian control, consistent with the way they are accounted for in extant biomathematical models.
      Citation: Clocks & Sleep
      PubDate: 2022-02-11
      DOI: 10.3390/clockssleep4010005
      Issue No: Vol. 4, No. 1 (2022)
  • Clocks & Sleep, Vol. 4, Pages 37-51: Depriving Mice of Sleep also
           Deprives of Food

    • Authors: Nina Đukanović, Francesco La Spada, Yann Emmenegger, Guy Niederhäuser, Frédéric Preitner, Paul Franken
      First page: 37
      Abstract: Both sleep-wake behavior and circadian rhythms are tightly coupled to energy metabolism and food intake. Altered feeding times in mice are known to entrain clock gene rhythms in the brain and liver, and sleep-deprived humans tend to eat more and gain weight. Previous observations in mice showing that sleep deprivation (SD) changes clock gene expression might thus relate to altered food intake, and not to the loss of sleep per se. Whether SD affects food intake in the mouse and how this might affect clock gene expression is, however, unknown. We therefore quantified (i) the cortical expression of the clock genes Per1, Per2, Dbp, and Cry1 in mice that had access to food or not during a 6 h SD, and (ii) food intake during baseline, SD, and recovery sleep. We found that food deprivation did not modify the SD-incurred clock gene changes in the cortex. Moreover, we discovered that although food intake during SD did not differ from the baseline, mice lost weight and increased food intake during subsequent recovery. We conclude that SD is associated with food deprivation and that the resulting energy deficit might contribute to the effects of SD that are commonly interpreted as a response to sleep loss.
      Citation: Clocks & Sleep
      PubDate: 2022-02-11
      DOI: 10.3390/clockssleep4010006
      Issue No: Vol. 4, No. 1 (2022)
  • Clocks & Sleep, Vol. 4, Pages 52-65: Hormone Targets for the Treatment of
           Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative

    • Authors: Alexandre González-Rodríguez, José Haba-Rubio, Judith Usall, Mentxu Natividad, Virginia Soria, Javier Labad, José A. Monreal
      First page: 52
      Abstract: While the early identification of insomnia in patients with schizophrenia is of clinical relevance, the use of specific compounds to treat insomnia has been studied less in postmenopausal women with schizophrenia. We aimed to explore the effects of melatonin, sex hormones, and raloxifene for the treatment of insomnia in these populations. Although melatonin treatment improved the quality and efficiency of the sleep of patients with schizophrenia, few studies have explored its use in postmenopausal women with schizophrenia. The estrogen and progesterone pathways are dysregulated in major psychiatric disorders, such as in schizophrenia. While, in the context of menopause, a high testosterone-to-estradiol ratio is associated with higher frequencies of depressive symptoms, the effects of estradiol and other sex hormones on sleep disorders in postmenopausal women with schizophrenia has not been sufficiently investigated. Raloxifene, a selective estrogen receptor modulator, has shown positive effects on sleep disorders in postmenopausal women. Future studies should investigate the effectiveness of hormonal compounds on insomnia in postmenopausal women with schizophrenia.
      Citation: Clocks & Sleep
      PubDate: 2022-02-15
      DOI: 10.3390/clockssleep4010007
      Issue No: Vol. 4, No. 1 (2022)
  • Clocks & Sleep, Vol. 4, Pages 66-79: The Importance of Sleep and Circadian
           Rhythms for Vaccination Success and Susceptibility to Viral Infections

    • Authors: Nina C. M. Schmitz, Ysbrand D. van der Werf, Heidi M. Lammers-van der Holst
      First page: 66
      Abstract: Sleep and circadian rhythms are closely involved in the immune system and its regulation. Here, we describe this relationship and provide recommendations regarding the influence of sleep and circadian rhythms on vaccination success. We review studies investigating how viral susceptibility is influenced by changes in immunological parameters as a consequence of sleep deprivation. Short sleep duration and poor sleep efficiency both appear to be strong factors leading to greater vulnerability. In addition, both sleep duration and the time of day of the vaccination seem to be associated with the magnitude of the antibody response after vaccination. Based on these findings, a recommendation would consist of a sleep duration of 7 h or more every night to both reduce the risk of infection and to optimize the efficacy of vaccination with respect to circadian timing. Improving sleep quality and its circadian timing can potentially play a role in preventing infection and in vaccination benefits. In conclusion, sufficient (or longer) sleep duration is important in both reducing susceptibility to infection and increasing antibody response after vaccination.
      Citation: Clocks & Sleep
      PubDate: 2022-02-16
      DOI: 10.3390/clockssleep4010008
      Issue No: Vol. 4, No. 1 (2022)
  • Clocks & Sleep, Vol. 4, Pages 80-87: Measuring Sleep Health Disparities
           with Polysomnography: A Systematic Review of Preliminary Findings

    • Authors: Faustin Armel Etindele Sosso
      First page: 80
      Abstract: Socioeconomic status (SES) has an unrecognized influence on behavioral risk factors as well as public health strategies related to sleep health disparities. In addition to that, objectively measuring SES’ influence on sleep health is challenging. A systematic review of polysomnography (PSG) studies investigating the relation between SES and sleep health disparities is worthy of interest and holds potential for future studies and recommendations. A literature search in databases was conducted following Prisma guidelines. Search strategy identified seven studies fitting within the inclusion criteria. They were all cross-sectional studies with only adults. Except for one study conducted in India, all of these studies took place in western countries. Overall emerging trends are: (1) low SES with its indicators (income, education, occupation and employment) are negatively associated with PSG parameters and (2) environmental factors (outside noise, room temperature and health worries); sex/gender and BMI were the main moderators of the relation between socioeconomic indicators and the variation of sleep recording with PSG. Socioeconomic inequalities in sleep health can be measured objectively. It will be worthy to examine the SES of participants and patients before they undergo PSG investigation. PSG studies should always collect socioeconomic data to discover important connections between SES and PSG. It will be interesting to compare PSG data of people from different SES in longitudinal studies and analyze the intensity of variations through time.
      Citation: Clocks & Sleep
      PubDate: 2022-02-18
      DOI: 10.3390/clockssleep4010009
      Issue No: Vol. 4, No. 1 (2022)
  • Clocks & Sleep, Vol. 4, Pages 88-99: Pre-Sleep Cognitive Arousal Is
           Negatively Associated with Sleep Misperception in Healthy Sleepers during
           Habitual Environmental Noise Exposure: An Actigraphy Study

    • Authors: Rachel L. Sharman, Michael L. Perlis, Célyne H. Bastien, Nicola L. Barclay, Jason G. Ellis, Greg J. Elder
      First page: 88
      Abstract: Specific noises (e.g., traffic or wind turbines) can disrupt sleep and potentially cause a mismatch between subjective sleep and objective sleep (i.e., “sleep misperception”). Some individuals are likely to be more vulnerable than others to noise-related sleep disturbances, potentially as a result of increased pre-sleep cognitive arousal. The aim of the present study was to examine the relationships between pre-sleep cognitive arousal and sleep misperception. Sixteen healthy sleepers participated in this naturalistic, observational study. Three nights of sleep were measured using actigraphy, and each 15-s epoch was classified as sleep or wake. Bedside noise was recorded, and each 15-s segment was classified as containing noise or no noise and matched to actigraphy. Participants completed measures of habitual pre-sleep cognitive and somatic arousal and noise sensitivity. Pre-sleep cognitive and somatic arousal levels were negatively associated with subjective–objective total sleep time discrepancy (p < 0.01). There was an association between sleep/wake and noise presence/absence in the first and last 90 min of sleep (p < 0.001). These results indicate that higher levels of habitual pre-sleep arousal are associated with a greater degree of sleep misperception, and even in healthy sleepers, objective sleep is vulnerable to habitual bedside noise.
      Citation: Clocks & Sleep
      PubDate: 2022-02-24
      DOI: 10.3390/clockssleep4010010
      Issue No: Vol. 4, No. 1 (2022)
  • Clocks & Sleep, Vol. 4, Pages 100-113: Obesity, Sex, Snoring and Severity
           of OSA in a First Nation Community in Saskatchewan, Canada

    • Authors: James A. Dosman, Chandima P. Karunanayake, Mark Fenton, Vivian R. Ramsden, Jeremy Seeseequasis, Robert Skomro, Shelley Kirychuk, Donna C. Rennie, Kathleen McMullin, Brooke P. Russell, Niels Koehncke, Sylvia Abonyi, Malcolm King, Punam Pahwa
      First page: 100
      Abstract: Sleep disorders have been related to body weight, social conditions, and a number of comorbidities. These include high blood pressure and type 2 diabetes, both of which are prevalent in the First Nations communities. We explored relationships between obstructive sleep apnea (OSA) and risk factors including social, environmental, and individual circumstances. An interviewer-administered survey was conducted with adult participants in 2018–2019 in a First Nations community in Saskatchewan, Canada. The survey collected information on demographic variables, individual and contextual determinants of sleep health, and objective clinical measurements. The presence of OSA was defined as an apnea–hypopnea index (AHI) ≥5. Multiple ordinal logistic regression analysis was conducted to examine relationships between the severity of OSA and potential risk factors. In addition to the survey, 233 men and women participated in a Level 3 one-night home sleep test. Of those, 105 (45.1%) participants were reported to have obstructive sleep apnea (AHI ≥ 5). Mild and moderately severe OSA (AHI ≥ 5 to <30) was present in 39.9% and severe OSA (AHI ≥ 30) was identified in 5.2% of participants. Being male, being obese, and snoring loudly were significantly associated with severity of OSA. The severity of OSA in one First Nation appears relatively common and may be related to mainly individual factors such as loud snoring, obesity, and sex.
      Citation: Clocks & Sleep
      PubDate: 2022-02-24
      DOI: 10.3390/clockssleep4010011
      Issue No: Vol. 4, No. 1 (2022)
  • Clocks & Sleep, Vol. 4, Pages 114-128: Circadian and Sleep Modulation of
           Dreaming in Women with Major Depression

    • Authors: Angelina Birchler-Pedross, Sylvia Frey, Christian Cajochen, Sarah L. Chellappa
      First page: 114
      Abstract: Growing evidence indicates an association between reduced dream recall and depressive symptomatology. Here, we tested the prediction that reduced dream recall in individuals experiencing major depressive disorder (MDD) is due to alterations in circadian and sleep processes. Nine young healthy women (20–31 years) and eight young unmedicated women (20–31 years) diagnosed with MDD underwent a 40 h multiple nap protocol with ten alternating cycles of 150 min wake/75 min sleep under a stringently controlled circadian laboratory protocol. After each nap, we assessed dream recall, number of dreams and dream emotional load using the Sleep Mentation Questionnaire. Dream recall and the number of dreams did not significantly differ between groups (pFDR > 0.1). However, there was a significant difference for the dream emotional load (interaction of “Group” vs. “Time”, pFDR = 0.01). Women with MDD had a two-fold higher (negative) emotional load as compared to healthy control women, particularly after naps during the circadian night (between ~22:00 h and ~05:00 h; Tukey–Kramer test, p = 0.009). Furthermore, higher (negative) dream emotional load was associated with impaired mood levels in both groups (R2 = 0.71; p < 0.001). Our findings suggest that the circadian and sleep modulation of dreaming may remain intact in unmedicated young women experiencing MDD.
      Citation: Clocks & Sleep
      PubDate: 2022-02-28
      DOI: 10.3390/clockssleep4010012
      Issue No: Vol. 4, No. 1 (2022)
  • Clocks & Sleep, Vol. 4, Pages 129-144: The Effects of Parental
           Intervention on Sleep Patterns and Electronic Media Exposure in Young

    • Authors: Ofra Flint Bretler, Orna Tzischinsky, Kfir Asraf, Tamar Shochat
      First page: 129
      Abstract: Objective: This study evaluated the effectiveness of a parent-focused intervention aimed at the promotion of healthy sleep patterns and controlled exposure to electronic media (EM) in young adolescents. Participants: The sample included 70 dyads of parents (68 mothers and 2 fathers) and adolescents. Intervention and control groups each consisted of 35 young adolescents with a mean age of 10.7 (0.9) years old. Methods: Three waves of data collection included baseline, post-intervention, and 3 month follow-up. In each wave, adolescents reported habitual electronic media exposure and sleep patterns for a week and wore an actigraph for five nights. Parents in the intervention group participated in a six-session interactive workshop, while parents in the control group received equivalent written information by mail. Results: The intervention led to earlier bedtimes (p < 0.001), increased sleep efficiency (p < 0.01), increased sleep duration (p < 0.001) and reduced video games exposure (p < 0.01). Benefits were maintained at the follow-up. Conclusion: Interventions tailored for parents can create lasting positive changes in sleep patterns and EM exposure in young adolescents.
      Citation: Clocks & Sleep
      PubDate: 2022-03-01
      DOI: 10.3390/clockssleep4010013
      Issue No: Vol. 4, No. 1 (2022)
  • Clocks & Sleep, Vol. 4, Pages 145-159: Sedative–Hypnotic Activity of
           the Water Extracts of Coptidis Rhizoma in Rodents

    • Authors: Hye-Young Joung, Minsook Ye, Miyoung Lee, Yunki Hong, Minji Kim, Kyung Soo Kim, Insop Shim
      First page: 145
      Abstract: Many medicinal plants have been used in Asia for treating a variety of mental diseases, including insomnia and depression. However, their sedative–hypnotic effects and mechanisms have not been clarified yet. Accordingly, the objective of this study was to investigate the sedative–hypnotic effects of water extracts of five medicinal plants: Coptidis Rhizoma, Lycii Fructus, Angelicae sinensis Radix, Bupleuri Radix, and Polygonum multiflorum Thunberg. The binding abilities of five medicinal plant extracts to the GABAA–BZD and 5-HT2C receptors were compared. Their abilities to activate arylalkylamine N-acetyltransferase (AANAT), a melatonin synthesis enzyme, in pineal cells were also determined. Following in vitro tests, the sedative and hypnotic activities of extracts with the highest activities were determined in an animal sleep model. In the binding assay, the water extracts of Coptidis Rhizoma (WCR) showed high binding affinity to the GABAA–BZD and 5-HT2C receptors in a dose-dependent manner. Additionally, WCR increased the AANAT activity up to five times compared with the baseline level. Further animal sleep model experiments showed that WCR potentiated pentobarbital-induced sleep by prolonging the sleep time. It also decreased the sleep onset time in mice. In addition, WCR reduced wake time and increased non-rapid eye movement (NREM) sleep without EEG power density (percentages of δ, θ, and α waves) during NREM sleep in rats. WCR could effectively induce NREM sleep without altering the architectural physiologic profile of sleep. This is the first report of the sedative–hypnotic effect of Coptidis Rhizoma possibly by regulating GABAA and 5-HT2C receptors and by activating AANAT activity.
      Citation: Clocks & Sleep
      PubDate: 2022-03-04
      DOI: 10.3390/clockssleep4010014
      Issue No: Vol. 4, No. 1 (2022)
  • Clocks & Sleep, Vol. 4, Pages 160-171: Sleep Loss, Daytime Sleepiness, and
           Neurobehavioral Performance among Adolescents: A Field Study

    • Authors: Tzischinsky Orna, Barel Efrat
      First page: 160
      Abstract: The current study investigates the impact of sleep loss on neurobehavioral functioning and sleepiness in a natural setting among healthy adolescents. Fifty-nine adolescents (32 females) from grades 7 to 12 (mean age of 16.29 ± 1.86 years) participated in the study. All participants wore the actigraph for a continuous five to seven days, including school and nonschool days. Subjective sleepiness and neurobehavioral performance (using the psychomotor vigilance test and the digit symbol substitution test) were measured three times a day on two school days and one nonschool day. The results presented that sleep loss influenced subjective sleepiness reports, showing higher sleepiness scores following sleep loss than following sufficient night sleep. Neurobehavioral functioning across all measurements was also significantly worse following sleep loss. Furthermore, participants performed worse on weekday morning assessments than on assessments at other times of the day following sleep loss. These findings suggest that sleep loss in natural settings has a significant impact on neurobehavioral performance and subjective sleepiness. Our findings have essential implications for public policy on school schedules.
      Citation: Clocks & Sleep
      PubDate: 2022-03-07
      DOI: 10.3390/clockssleep4010015
      Issue No: Vol. 4, No. 1 (2022)
  • Clocks & Sleep, Vol. 4, Pages 172-184: The Relationship between Acceptance
           and Sleep–Wake Quality before, during, and after the First Italian
           COVID-19 Lockdown

    • Authors: Marco Fabbri, Luca Simione, Monica Martoni, Marco Mirolli
      First page: 172
      Abstract: Several studies have reported that the COVID-19 pandemic has had deleterious effects on sleep quality and mood, but the mechanisms underlying these effects are not clearly understood. Recently, it has been shown that the acceptance component of mindfulness reduces anxiety, and, in turn, lower anxiety improves sleep quality. The purpose of this cross-sectional study was to assess changes in mindfulness traits, sleep–wake quality, and general distress, before, during, and after the first COVID-19 wave, testing the model in which acceptance influences sleep through anxiety in each period. A total of 250 participants were recruited before (Pre-Lockdown group: 69 participants, 29 females, 33.04 ± 12.94 years), during (Lockdown group: 78 participants, 59 females, 29.174 ± 8.50 years), and after (After-Lockdown group: 103 participants, 86 females, 30.29 ± 9.46 years) the first Italian lockdown. In each group, self-report questionnaires, assessing mindfulness facets, distress, and sleep–wake quality, were administered and assessed. The Lockdown group reported lower acceptance and higher depression, while the After-Lockdown group reported lower sleep–wake quality and higher anxiety. The results of the path analysis confirmed that higher acceptance reduced anxiety and higher anxiety decreased sleep–wake quality in all groups. Our results confirm that acceptance influences sleep through the mediating role of anxiety.
      Citation: Clocks & Sleep
      PubDate: 2022-03-07
      DOI: 10.3390/clockssleep4010016
      Issue No: Vol. 4, No. 1 (2022)
  • Clocks & Sleep, Vol. 4, Pages 185-201: Physical Interaction between
           Cyclin-Dependent Kinase 5 (CDK5) and Clock Factors Affects the Circadian
           Rhythmicity in Peripheral Oscillators

    • Authors: Jürgen A. Ripperger, Rohit Chavan, Urs Albrecht, Andrea Brenna
      First page: 185
      Abstract: Circadian rhythms are self-sustained oscillators with a period of 24 h that is based on the output of transcriptional and post-translational feedback loops. Phosphorylation is considered one of the most important post-translational modifications affecting rhythmicity from cyanobacteria to mammals. For example, the lack of cyclin-dependent kinase 5 (CDK5) shortened the period length of the circadian oscillator in the Suprachiasmatic Nuclei (SCN) of mice via the destabilization of the PERIOD 2 (PER2) protein. Here, we show that CDK5 kinase activity and its interaction with clock components, including PER2 and CLOCK, varied over time in mouse embryonic fibroblast cells. Furthermore, the deletion of Cdk5 from cells resulted in a prolonged period and shifted the transcription of clock-controlled genes by about 2 to 4 h with a simple delay of chromatin binding of ARNTL (BMAL1) CLOCK. Taken together, our data indicate that CDK5 is critically involved in regulating the circadian clock in vitro at the molecular level.
      Citation: Clocks & Sleep
      PubDate: 2022-03-09
      DOI: 10.3390/clockssleep4010017
      Issue No: Vol. 4, No. 1 (2022)
  • Clocks & Sleep, Vol. 4, Pages 202-207: Sleep Deprivation Does Not
           Influence Photic Resetting of Circadian Activity Rhythms in Drosophila

    • Authors: David C. Negelspach, Sevag Kaladchibachi, Hannah K. Dollish, Fabian-Xosé Fernandez
      First page: 202
      Abstract: Previous investigations in humans and rodent animal models have assessed the interplay of sleep in the circadian system’s phase responses to nighttime light exposure. The resulting data have been mixed, but generally support a modulatory role for sleep in circadian photic resetting (not an absolute requirement). Drosophila have been historically used to provide important insights in the sleep and circadian sciences. However, no experiments to date have evaluated how immediate sleep need or recent sleep history affects their pacemaker’s phase readjustments to light. We did so in the current study by (1) forcing separate groups of animals to stay awake for 1 or 4 h after they were shown a broadspectrum pulse (15 min during the first half of the night, 950 lux), or (2) placing them on a restricted sleep schedule for a week before light presentation without any subsequent sleep disruption. Forced sleep restriction, whether acute or chronic, did not alter the size of light-induced phase shifts. These data are consistent with observations made in other diurnal animals and raise the possibility, more broadly, that phototherapies applied during sleep—such as may be necessary during the winter months—may still be efficacious in individuals experiencing sleep-continuity problems such as insomnia.
      Citation: Clocks & Sleep
      PubDate: 2022-03-21
      DOI: 10.3390/clockssleep4010018
      Issue No: Vol. 4, No. 1 (2022)
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