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  Subjects -> PSYCHOLOGY (Total: 983 journals)
Showing 601 - 174 of 174 Journals sorted by number of followers
Nature Human Behaviour     Hybrid Journal   (Followers: 56)
American Journal of Applied Psychology     Open Access   (Followers: 55)
Annual Review of Organizational Psychology and Organizational Behavior     Full-text available via subscription   (Followers: 52)
Frontiers in Behavioral Neuroscience     Open Access   (Followers: 30)
Violence and Gender     Full-text available via subscription   (Followers: 23)
Counseling Psychology and Psychotherapy     Open Access   (Followers: 21)
Behavior Analysis in Practice     Full-text available via subscription   (Followers: 19)
Current Opinion in Psychology     Hybrid Journal   (Followers: 16)
Current Addiction Reports     Hybrid Journal   (Followers: 15)
Sport, Exercise, and Performance Psychology     Full-text available via subscription   (Followers: 15)
Journal of Social and Political Psychology     Open Access   (Followers: 15)
Review Journal of Autism and Developmental Disorders     Hybrid Journal   (Followers: 15)
Journal of Music Therapy     Hybrid Journal   (Followers: 14)
Psychology of Sexual Orientation and Gender Diversity     Full-text available via subscription   (Followers: 14)
Clinical Practice in Pediatric Psychology     Full-text available via subscription   (Followers: 14)
Autism's Own     Open Access   (Followers: 13)
Case Studies in Sport and Exercise Psychology     Hybrid Journal   (Followers: 13)
Journal of Gender-Based Violence     Hybrid Journal   (Followers: 13)
Glossa Psycholinguistics     Open Access   (Followers: 12)
Journal of Experimental Psychology : Animal Learning and Cognition     Full-text available via subscription   (Followers: 11)
Health Psychology Open     Open Access   (Followers: 11)
Clinical Psychology and Special Education     Open Access   (Followers: 10)
Current Opinion in Behavioral Sciences     Hybrid Journal   (Followers: 10)
Couple and Family Psychology : Research and Practice     Full-text available via subscription   (Followers: 10)
Journal of Psychosocial Rehabilitation and Mental Health     Hybrid Journal   (Followers: 10)
Behavior Analysis: Research and Practice     Full-text available via subscription   (Followers: 8)
Music Therapy Perspectives     Hybrid Journal   (Followers: 8)
Addictive Behaviors Reports     Open Access   (Followers: 8)
International Journal of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 8)
Psychology of Consciousness : Theory, Research, and Practice     Full-text available via subscription   (Followers: 7)
Evolutionary Behavioral Sciences     Full-text available via subscription   (Followers: 7)
Psychomusicology : Music, Mind, and Brain     Full-text available via subscription   (Followers: 7)
Asian American Journal of Psychology     Full-text available via subscription   (Followers: 7)
Contemporary School Psychology     Hybrid Journal   (Followers: 7)
Qualitative Psychology     Full-text available via subscription   (Followers: 6)
Creativity. Theories ? Research ? Applications     Open Access   (Followers: 6)
Cultural-Historical Psychology     Open Access   (Followers: 6)
Review of Behavioral Economics     Full-text available via subscription   (Followers: 6)
Internet Interventions : The application of information technology in mental and behavioural health     Open Access   (Followers: 6)
Decision     Full-text available via subscription   (Followers: 6)
Behavior Analyst     Hybrid Journal   (Followers: 6)
Neurology, Neuropsychiatry, Psychosomatics     Open Access   (Followers: 6)
Evolutionary Psychological Science     Hybrid Journal   (Followers: 6)
Journal of Behavioral Addictions     Open Access   (Followers: 5)
Journal of Cognitive Historiography     Full-text available via subscription   (Followers: 5)
Journal of Individual Psychology     Full-text available via subscription   (Followers: 5)
Porn Studies     Hybrid Journal   (Followers: 5)
Journal of Social, Behavioral, and Health Sciences     Open Access   (Followers: 5)
OA Autism     Open Access   (Followers: 5)
Social Psychology and Society     Open Access   (Followers: 5)
European Journal of Investigation in Health, Psychology and Education     Open Access   (Followers: 5)
Cognitive Research : Principles and Implications     Open Access   (Followers: 5)
Counselling and Values     Hybrid Journal   (Followers: 5)
Revista Científica Arbitrada de la Fundación MenteClara     Open Access   (Followers: 5)
Archives of Scientific Psychology     Open Access   (Followers: 5)
Drama Therapy Review     Hybrid Journal   (Followers: 4)
Psyke & Logos     Open Access   (Followers: 4)
Current Behavioral Neuroscience Reports     Hybrid Journal   (Followers: 4)
International Journal of Educational and Psychological Researches     Open Access   (Followers: 4)
Policy Insights from the Behavioral and Brain Sciences     Full-text available via subscription   (Followers: 4)
Voices : A World Forum for Music Therapy     Open Access   (Followers: 4)
SUCHT - Zeitschrift für Wissenschaft und Praxis / Journal of Addiction Research and Practice     Hybrid Journal   (Followers: 4)
African Journal of Cross-Cultural Psychology and Sport Facilitation     Full-text available via subscription   (Followers: 4)
Journal of Amateur Sport     Open Access   (Followers: 3)
Psychology and Law     Open Access   (Followers: 3)
Phenomenology and Mind     Open Access   (Followers: 3)
Spirituality in Clinical Practice     Full-text available via subscription   (Followers: 3)
Nigerian Journal of Guidance and Counselling     Full-text available via subscription   (Followers: 2)
Zeitschrift für Neuropsychologie     Hybrid Journal   (Followers: 2)
Lebenswelt : Aesthetics and philosophy of experience     Open Access   (Followers: 2)
Behavioral Development Bulletin     Full-text available via subscription   (Followers: 2)
Research in Psychology and Behavioral Sciences     Open Access   (Followers: 2)
Zeitschrift für Psychiatrie, Psychologie und Psychotherapie     Hybrid Journal   (Followers: 2)
Couple and Family Psychoanalysis     Full-text available via subscription   (Followers: 2)
Multisensory Research     Hybrid Journal   (Followers: 2)
Social Action : The Journal for Social Action in Counseling and Psychology     Free   (Followers: 2)
European Journal of Behavior Analysis     Hybrid Journal   (Followers: 2)
Language and Text     Open Access   (Followers: 2)
Social Inclusion     Open Access   (Followers: 2)
International Review of Social Psychology / Revue Internationale de Psychologie Sociale     Open Access   (Followers: 2)
Journal of Language Aggression and Conflict     Hybrid Journal   (Followers: 2)
Inquiry : Critical Thinking Across the Disciplines     Full-text available via subscription   (Followers: 2)
Journal of Dynamic Decision Making     Open Access   (Followers: 2)
Phenomenology & Practice     Open Access   (Followers: 2)
Sexual Offending : Theory, Research, and Prevention     Open Access   (Followers: 2)
Voices : The Art and Science of Psychotherapy     Full-text available via subscription   (Followers: 1)
Jurnal Psikologi Pendidikan dan Konseling : Jurnal Kajian Psikologi Pendidikan dan Bimbingan Konseling     Open Access   (Followers: 1)
Acta de Investigación Psicológica     Open Access   (Followers: 1)
Psychosomatic Medicine and General Practice     Open Access   (Followers: 1)
Journal of Numerical Cognition     Open Access   (Followers: 1)
Canadian Art Therapy Association     Hybrid Journal   (Followers: 1)
Quantitative Methods for Psychology     Open Access   (Followers: 1)
Wawasan     Open Access   (Followers: 1)
Zeitschrift für Gerontopsychologie und -psychiatrie     Full-text available via subscription   (Followers: 1)
Psicologia e Saber Social     Open Access   (Followers: 1)
Pragmatic Case Studies in Psychotherapy     Open Access   (Followers: 1)
Psychological Science and Education     Open Access   (Followers: 1)
Psychological Science and Education psyedu.ru     Open Access   (Followers: 1)
Activités     Open Access   (Followers: 1)
Journal of Mind and Medical Sciences     Open Access   (Followers: 1)
Journal of Educational, Cultural and Psychological Studies     Open Access   (Followers: 1)
Journal of Addiction & Prevention     Open Access   (Followers: 1)
Russian Psychological Journal     Open Access   (Followers: 1)
Epiphany     Open Access   (Followers: 1)
Neuropsychoanalysis : An Interdisciplinary Journal for Psychoanalysis and the Neurosciences     Hybrid Journal   (Followers: 1)
Zeitschrift für Pädagogische Psychologie     Hybrid Journal   (Followers: 1)
Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie     Hybrid Journal   (Followers: 1)
Canadian Journal of Art Therapy : Research, Practice, and Issues     Hybrid Journal   (Followers: 1)
Tempo Psicanalitico     Open Access   (Followers: 1)
FLEKS : Scandinavian Journal of Intercultural Theory and Practice     Open Access   (Followers: 1)
Undecidable Unconscious : A Journal of Deconstruction and Psychoanalysis     Full-text available via subscription   (Followers: 1)
Brain Informatics     Open Access   (Followers: 1)
Journal of Psychology in Africa     Full-text available via subscription   (Followers: 1)
Revista de Estudios e Investigación en Psicología y Educación     Open Access  
Persona Studies     Open Access  
Indigenous : Jurnal Ilmiah Psikologi     Open Access  
Intuisi : Jurnal Psikologi Ilmiah     Open Access  
Setting     Full-text available via subscription  
Revista de Psicologia     Open Access  
Behaviormetrika     Hybrid Journal  
European Yearbook of the History of Psychology     Full-text available via subscription  
Interacciones. Revista de Avances en Psicología     Open Access  
Psicologia     Open Access  
Journal für Psychoanalyse     Open Access  
Siglo Cero. Revista Española sobre Discapacidad Intelectual     Open Access  
Miscelánea Comillas. Revista de Ciencias Humanas y Sociales     Open Access  
New School Psychology Bulletin     Open Access  
TESTFÓRUM     Open Access  
S : Journal of the Circle for Lacanian Ideology Critique     Open Access  
International Journal of Psychoanalysis and Education     Open Access  
Quaderns de Psicologia     Open Access  
Satir International Journal     Open Access  
Mudanças - Psicologia da Saúde     Open Access  
Journal of Creating Value     Full-text available via subscription  
Tajdida : Jurnal Pemikiran dan Gerakan Muhammadiyah     Open Access  
Estudos Interdisciplinares em Psicologia     Open Access  
Psychologie du Travail et des Organisations     Hybrid Journal  
Cendekia : Jurnal Kependidikan dan Kemasyarakatan     Open Access  
Visnyk of NTUU - Philosophy. Psychology. Pedagogics     Open Access  
Revista Costarricense de Psicología     Open Access  
Informes Psicológicos     Open Access  
Jurnal Psikologi     Open Access  
Zeitschrift für Differentielle und Diagnostische Psychologie     Full-text available via subscription  
Klart språk i Norden     Open Access  
Revista Pequén     Open Access  
Pensando Psicología     Open Access  
Ciencias Psicológicas     Open Access  
Revista de Cultura Teológica     Open Access  
Journal of Modern Foreign Psychology     Open Access  
Experimental Psychology (Russia)     Open Access  
Elpis - Czasopismo Teologiczne Katedry Teologii Prawosławnej Uniwersytetu w Białymstoku     Open Access  
International Journal of Comparative Psychology     Open Access  
Гуманітарний вісник Запорізької державної інженерної академії     Open Access  
Revista Latinoamericana de Psicología     Open Access  
Cogent Psychology     Open Access  
Ajayu Órgano de Difusión Científica del Departamento de Psicología UCBSP     Open Access  
Psicologia     Open Access  
Análise Psicológica     Open Access  
Rivista Internazionale di Filosofia e Psicologia     Open Access  
Facta Universitatis, Series : Philosophy, Sociology, Psychology and History     Open Access  
Universal Journal of Psychology     Open Access  
Revista Internacional de Psicologia     Open Access  
Terapia familiare     Full-text available via subscription  
Studi Junghiani     Full-text available via subscription  
Ruolo Terapeutico (IL)     Full-text available via subscription  
Rivista Sperimentale di Freniatria     Full-text available via subscription  
Rivista di Psicoterapia Relazionale     Full-text available via subscription  
Ricerche di psicologia     Full-text available via subscription  
Ricerca Psicoanalitica : Journal of the Relationship in Psychoanalysis     Open Access  
Quaderni di Gestalt     Full-text available via subscription  
Psicoterapia e Scienze Umane     Full-text available via subscription  
Psicologia di Comunità. Gruppi, ricerca-azione, modelli formativi     Full-text available via subscription  
Psicologia della salute     Full-text available via subscription  
Psicobiettivo     Full-text available via subscription  
Psicoanalisi     Full-text available via subscription  
Ipnosi     Full-text available via subscription  
Interazioni     Full-text available via subscription  
Gruppi     Full-text available via subscription  
Forum : Journal of the International Association of Group Psychoterapy     Full-text available via subscription  
Educazione sentimentale     Full-text available via subscription  
Revista Wímb Lu     Open Access  
International Perspectives in Psychology : Research, Practice, Consultation     Full-text available via subscription  
Lernen und Lernstörungen     Hybrid Journal  
Inkanyiso : Journal of Humanities and Social Sciences     Open Access  
Online Readings in Psychology and Culture     Open Access  
Winnicott e-prints     Open Access  
Trivium : Estudos Interdisciplinares     Open Access  
Temas em Psicologia     Open Access  
Stylus (Rio de Janeiro)     Open Access  
Salud & Sociedad: investigaciones en psicologia de la salud y psicologia social     Open Access  
Revista Psicopedagogia     Open Access  
Revista Psicologia Política     Open Access  
Revista Psicologia e Saúde     Open Access  
Revista Psicologia     Open Access  
Revista Mexicana de Orientación Educativa     Open Access  
Revista do NUFEN     Open Access  
Revista de Etologia     Open Access  
Revista da SPAGESP     Open Access  
Revista da SBPH     Open Access  
Revista da Abordagem Gestáltica     Open Access  

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Frontiers in Behavioral Neuroscience
Journal Prestige (SJR): 1.749
Citation Impact (citeScore): 3
Number of Followers: 30  

  This is an Open Access Journal Open Access journal
ISSN (Online) 1662-5153
Published by Frontiers Media Homepage  [96 journals]
  • Strain-dependent regulation of hippocampal long-term potentiation by
           dopamine D1/D5 receptors in mice

    • Authors: Hardy Hagena, Martin Stacho, Arthur Laja, Denise Manahan-Vaughan
      Abstract: The magnitude and persistency of long-term potentiation (LTP) in the rodent hippocampus is species-dependent: rats express more robust and more prolonged LTP in response to a broader afferent frequency range than mice. The C57Bl/6 mouse is an extremely popular murine strain used in studies of hippocampal synaptic plasticity and spatial learning. Recently it was reported that it expresses impoverished LTP compared to other murine strains. Given the important role of the dopamine D1/D5 receptor (D1/D5R) in the maintenance of LTP and in memory consolidation, we explored to what extent strain-dependent differences in LTP in mice are determined by differences in D1/D5R-control. In CaOlaHsd mice, robust LTP was induced that lasted for over 24 h and which was significantly greater in magnitude than LTP induced in C57Bl/6 mice. Intracerebral treatment with a D1/D5R-antagonist (SCH23390) prevented both the early and late phase of LTP in CaOlaHsd mice, whereas only late-LTP was impaired in C57Bl/6 mice. Treatment with a D1/D5R-agonist (Chloro-PB) facilitated short-term potentiation (STP) into LTP (> 24 h) in both strains, whereby effects became evident earlier in CaOlaHsd compared to C57Bl/6 mice. Immunohistochemical analysis revealed a significantly higher expression of D1-receptors in the stratum lacunosum moleculare of CaOlaHsd compared to C57Bl/6 mice. These findings highlight differences in D1/D5R- dependent regulation of strain-dependent variations in hippocampal LTP in C57Bl/6 and CaOlaHsd mice, that may be mediated, in part, by differences in the expression of D1R in the hippocampus.
      PubDate: 2022-12-05T00:00:00Z
  • Environmental and genetic determinants of sensorimotor asymmetries in
           mother-infant interaction

    • Authors: Gianluca Malatesta, Daniele Marzoli, Luca Tommasi
      PubDate: 2022-12-05T00:00:00Z
  • Editorial: Prosocial and hypersocial behavior: From genes to circuits and

    • Authors: Miklos Toth
      PubDate: 2022-12-02T00:00:00Z
  • Event-related brain potential markers of visual and auditory perception: A
           useful tool for brain computer interface

    • Authors: Alice Mado Proverbio, Marta Tacchini, Kaijun Jiang
      Abstract: ObjectiveA majority of BCI systems, enabling communication with patients with locked-in syndrome, are based on electroencephalogram (EEG) frequency analysis (e.g., linked to motor imagery) or P300 detection. Only recently, the use of event-related brain potentials (ERPs) has received much attention, especially for face or music recognition, but neuro-engineering research into this new approach has not been carried out yet. The aim of this study was to provide a variety of reliable ERP markers of visual and auditory perception for the development of new and more complex mind-reading systems for reconstructing the mental content from brain activity.MethodsA total of 30 participants were shown 280 color pictures (adult, infant, and animal faces; human bodies; written words; checkerboards; and objects) and 120 auditory files (speech, music, and affective vocalizations). This paradigm did not involve target selection to avoid artifactual waves linked to decision-making and response preparation (e.g., P300 and motor potentials), masking the neural signature of semantic representation. Overall, 12,000 ERP waveforms × 126 electrode channels (1 million 512,000 ERP waveforms) were processed and artifact-rejected.ResultsClear and distinct category-dependent markers of perceptual and cognitive processing were identified through statistical analyses, some of which were novel to the literature. Results are discussed from the view of current knowledge of ERP functional properties and with respect to machine learning classification methods previously applied to similar data.ConclusionThe data showed a high level of accuracy (p ≤ 0.01) in the discriminating the perceptual categories eliciting the various electrical potentials by statistical analyses. Therefore, the ERP markers identified in this study could be significant tools for optimizing BCI systems [pattern recognition or artificial intelligence (AI) algorithms] applied to EEG/ERP signals.
      PubDate: 2022-11-29T00:00:00Z
  • Developmental trajectory of episodic-like memory in

    • Authors: Antonis Asiminas, Stephanie A. Lyon, Rosamund F. Langston, Emma R. Wood
      Abstract: IntroductionEpisodic memory formation requires the binding of multiple associations to a coherent episodic representation, with rich detail of times, places, and contextual information. During postnatal development, the ability to recall episodic memories emerges later than other types of memory such as object recognition. However, the precise developmental trajectory of episodic memory, from weaning to adulthood has not yet been established in rats. Spontaneous object exploration tasks do not require training, and allow repeated testing of subjects, provided novel objects are used on each trial. Therefore, these tasks are ideally suited for the study of the ontogeny of episodic memory and its constituents (e.g., object, spatial, and contextual memory).MethodsIn the present study, we used four spontaneous short-term object exploration tasks over two days: object (OR), object-context (OCR), object-place (OPR), and object-place-context (OPCR) recognition to characterise the ontogeny of episodic-like memory and its components in three commonly used outbred rat strains (Lister Hooded, Long Evans Hooded, and Sprague Dawley).ResultsIn longitudinal studies starting at 3–4 weeks of age, we observed that short term memory for objects was already present at the earliest time point we tested, indicating that it is established before the end of the third week of life (consistent with several other reports). Object-context memory developed during the fifth week of life, while both object-in-place and the episodic-like object-place-context memory developed around the seventh postnatal week. To control for the effects of previous experience in the development of associative memory, we confirmed these developmental trajectories using a cross-sectional protocol.DiscussionOur work provides robust evidence for different developmental trajectories of recognition memory in rats depending on the content and/or complexity of the associations and emphasises the utility of spontaneous object exploration tasks to assess the ontogeny of memory systems with high temporal resolution.
      PubDate: 2022-11-29T00:00:00Z
  • Development and validation of a system for the prediction of challenging
           behaviors of people with autism spectrum disorder based on a smart
           wearable shirt: A mixed-methods
           design|Background|Objectives|Methods|Results|Clinical trial registration

    • Authors: Moti Zwilling, Alberto Romano, Hay Hoffman, Meir Lotan, Riki Tesler
      Abstract: BackgroundMost people with autism spectrum disorder (ASD) present at least one form of challenging behavior (CB), causing reduced life quality, social interactions, and community-based service inclusion.ObjectivesThe current study had two objectives: (1) to assess the differences in physiological reaction to stressful stimuli between adults with and without high-functioning ASD; (2) to develop a system able to predict the incoming occurrence of a challenging behaviors (CBs) in real time and inform the caregiver that a CB is about to occur; (3) to evaluate the acceptability and usefulness of the developed system for users with ASD and their caregivers.MethodsComparison between physiological parameters will be conducted by enrolling two groups of 20 participants with and without ASD monitored while watching a relaxing and disturbing video. To understand the variations of the parameters that occur before the CB takes place, 10 participants with ASD who have aggressive or disruptive CBs will be monitored for 7 days. Then, an ML algorithm capable of predicting immediate CB occurrence based on physiological parameter variations is about to be developed. After developing the application-based algorithm, an efficient proof of concept (POC) will be carried out on one participant with ASD and CB. A focus group, including health professionals, will test the POC to identify the strengths and weaknesses of the developed system.ResultsHigher stress level is anticipated in the group of people with ASD looking at the disturbing video than in the typically developed peers. From the obtained data, the developed algorithm is used to predict CBs that are about to occur in the upcoming 1 min. A high level of satisfaction with the proposed technology and useful consideration for further developments are expected to emerge from the focus group.Clinical trial registration[https://clinicaltrials.gov/], identifier [NCT05340608].
      PubDate: 2022-11-29T00:00:00Z
  • Involvement of D2-like dopaminergic receptors in contextual fear
           conditioning in female rats: influence of estrous cycle

    • Authors: Camila de Oliveira Alves, Adriano Edgar Reimer, Amanda Ribeiro de Oliveira
      Abstract: Introduction: Dopamine has been increasingly recognized as a key neurotransmitter regulating fear/anxiety states. Nevertheless, the influence of sex and estrous cycle differences on the role of dopamine in fear responses needs further investigation. We aimed to evaluate the effects of sulpiride (a dopaminergic D2-like receptor antagonist) on contextual fear conditioning in females while exploring the influence of the estrous cycle.Methods: First, using a contextual fear conditioning paradigm, we assessed potential differences in acquisition, expression, and extinction of the conditioned freezing response in male and female (split in proestrus/estrus and metestrus/diestrus) Wistar rats. In a second cohort, we evaluated the effects of sulpiride (20 and 40 mg/kg) on contextual conditioned fear in females during proestrus/estrus and metestrus/diestrus. Potential nonspecific effects were assessed in motor activity assays (catalepsy and open-field tests).Results: No sex differences nor estrous cycle effects on freezing behavior were observed during the fear conditioning phases. Sulpiride reduced freezing expression in female rats. Moreover, females during the proestrus/estrus phases of the estrous cycle were more sensitive to the effects of sulpiride than females in metestrus/diestrus. Sulpiride did not cause motor impairments.Discussion: Although no sex or estrous cycle differences were observed in basal conditioned fear expression and extinction, the estrous cycle seems to influence the effects of D2-like antagonists on contextual fear conditioning.
      PubDate: 2022-11-28T00:00:00Z
  • Ranking the contribution of behavioral measures comprising oxycodone
           self-administration to reinstatement of drug-seeking in male and female
           rats|Introduction|Materials and methods|Results|Discussion

    • Authors: Suman K. Guha, Yanaira Alonso-Caraballo, Gillian S. Driscoll, Jessica A. Babb, Megan Neal, Nicholas J. Constantino, Tania Lintz, Elizabeth Kinard, Elena H. Chartoff
      Abstract: IntroductionRates of relapse to drug use during abstinence are among the highest for opioid use disorder (OUD). In preclinical studies, reinstatement to drug-seeking has been extensively studied as a model of relapse–but the work has been primarily in males. We asked whether biological sex contributes to behaviors comprising self-administration of the prescription opioid oxycodone in rats, and we calculated the relative contribution of these behavioral measures to reinstatement in male and female rats.Materials and methodsRats were trained to self-administer oxycodone (8 days, training phase), after which we examined oxycodone self-administration behaviors for an additional 14 days under three conditions in male and female rats: short access (ShA, 1 h/d), long access (LgA, 6 h/d), and saline self-administration. All rats were then tested for cue-induced reinstatement of drug-seeking after a 14-d forced abstinence period. We quantified the # of infusions, front-loading of drug intake, non-reinforced lever pressing, inter-infusion intervals, escalation of intake, and reinstatement responding on the active lever.ResultsBoth male and female rats in LgA and ShA conditions escalated oxycodone intake to a similar extent. However, males had higher levels of non-reinforced responding than females under LgA conditions, and females had greater levels of reinstatement responding than males. We then correlated each addiction-related measure listed above with reinstatement responding in males and females and ranked their respective relative contributions. Although the majority of behavioral measures associated with oxycodone self-administration did not show sex differences on their own, when analyzed together using partial least squares regression, their relative contributions to reinstatement were sex-dependent. Front-loading behavior was calculated to have the highest relative contribution to reinstatement in both sexes, with long and short inter-infusion intervals having the second greatest contribution in females and males, respectively.DiscussionOur results demonstrate sex differences in some oxycodone self-administration measures. More importantly, we demonstrate that a sex- dependent constellation of self-administration behaviors can predict the magnitude of reinstatement, which holds great promise for relapse prevention in people.
      PubDate: 2022-11-24T00:00:00Z
  • Longitudinal assessment of motor function following the unilateral
           intrastriatal 6-hydroxydopamine lesion model in
           mice|Introduction|Materials and methods|Results|Conclusion

    • Authors: Xiuping Sun, Xianglei Li, Ling Zhang, Yu Zhang, Xiaolong Qi, Siyuan Wang, Chuan Qin
      Abstract: IntroductionDespite the widespread use of the unilateral striatal 6-hydroxydopamine (6-OHDA) lesion model in mice in recent years, the stability of behavioral deficits in the 6-OHDA striatal mouse model over time is not yet clear, raising concerns about using this model to evaluate a compound’s long-term therapeutic effects.Materials and methodsIn the current study, mice were tested at regular intervals in the cylinder test and gait analysis beginning 3 days after 6-OHDA injection of 4 and 8 μg and lasting until 56 days post-lesion. Apomorphine-induced rotational test and rotarod test were also performed on Day 23 and 43 post-lesion, respectively. Immunohistochemistry for dopaminergic neurons stained by tyrosine hydroxylase (TH) was also performed.ResultsOur results showed that both the 4 and 8 μg 6-OHDA lesion groups exhibited forelimb use asymmetry with a preference for the ipsilateral (injection) side on Day 3 and until Day 21 post-lesion, but did not show forelimb asymmetry on Day 28 to 56 post-lesion. The 8 μg 6-OHDA lesion group still exhibited forelimb asymmetry on Day 28 and 42 post-lesion, but not on Day 56. The gait analysis showed that the contralateral front and hind step cycles increased from Day 3 to 42 post-lesion and recovered on Day 56 post-lesion. In addition, our results displayed a dose-dependent reduction in TH+ cells and TH+ fibers, as well as dose-dependent apomorphine-induced rotations. In the rotarod test, the 8 μg 6-OHDA lesion group, but not the 4 μg group, decreased the latency to fall on the rotarod on Day 43 post-lesion.ConclusionIn summary, unilateral striatal 6-OHDA injections of 4 and 8 μg induced spontaneous motor impairment in mice, which partially recovered starting on Day 28 post-lesion. Forced motor deficits were observed in the 8 g 6-OHDA lesion group, which remained stable on Day 43 post-lesion. In addition, the rotarod test and apomorphine-induced rotational test can distinguish between lesions of different extents and are useful tools for the assessment of functional recovery in studies screening novel potential therapies.
      PubDate: 2022-11-24T00:00:00Z
  • Loss of GABA co-transmission from cholinergic neurons impairs behaviors
           related to hippocampal, striatal, and medial prefrontal cortex functions

    • Authors: R. Oliver Goral, Kathryn M. Harper, Briana J. Bernstein, Sydney A. Fry, Patricia W. Lamb, Sheryl S. Moy, Jesse D. Cushman, Jerrel L. Yakel
      Abstract: Introduction: Altered signaling or function of acetylcholine (ACh) has been reported in various neurological diseases, including Alzheimer’s disease, Tourette syndrome, epilepsy among others. Many neurons that release ACh also co-transmit the neurotransmitter gamma-aminobutyrate (GABA) at synapses in the hippocampus, striatum, substantia nigra, and medial prefrontal cortex (mPFC). Although ACh transmission is crucial for higher brain functions such as learning and memory, the role of co-transmitted GABA from ACh neurons in brain function remains unknown. Thus, the overarching goal of this study was to investigate how a systemic loss of GABA co-transmission from ACh neurons affected the behavioral performance of mice.Methods: To do this, we used a conditional knock-out mouse of the vesicular GABA transporter (vGAT) crossed with the ChAT-Cre driver line to selectively ablate GABA co-transmission at ACh synapses. In a comprehensive series of standardized behavioral assays, we compared Cre-negative control mice with Cre-positive vGAT knock-out mice of both sexes.Results: Loss of GABA co-transmission from ACh neurons did not disrupt the animal’s sociability, motor skills or sensation. However, in the absence of GABA co-transmission, we found significant alterations in social, spatial and fear memory as well as a reduced reliance on striatum-dependent response strategies in a T-maze. In addition, male conditional knockout (CKO) mice showed increased locomotion.Discussion: Taken together, the loss of GABA co-transmission leads to deficits in higher brain functions and behaviors. Therefore, we propose that ACh/GABA co-transmission modulates neural circuitry involved in the affected behaviors.
      PubDate: 2022-11-24T00:00:00Z
  • C57BL/6N mice show a sub-strain specific resistance to the psychotomimetic
           effects of ketamine

    • Authors: Zofia Harda, Klaudia Misiołek, Marta Klimczak, Magdalena Chrószcz, Jan Rodriguez Parkitna
      Abstract: Repeated administration of subanesthetic doses of ketamine is a model of psychosis-like state in rodents. In mice, this treatment produces a range of behavioral deficits, including impairment in social interactions and locomotion. To date, these phenotypes were described primarily in the Swiss and C3H/HeHsd mouse strains. A few studies investigated ketamine-induced behaviors in the C57BL/6J strain, but to our knowledge the C57BL/6N strain was not investigated thus far. This is surprising, as both C57BL/6 sub-strains are widely used in behavioral and neuropsychopharmacological research, and are de facto standards for characterization of drug effects. The goal of this study was to determine if C57BL/6N mice are vulnerable to develop social deficits after 5 days withdrawal from sub-chronic ketamine treatment (5 days, 30 mg/kg, i.p.), an experimental schedule shown before to cause deficits in social interactions in C57BL/6J mice. Our results show that sub-chronic administration of ketamine that was reported to cause psychotic-like behavior in C57BL/6J mice does not induce appreciable behavioral alterations in C57BL/6N mice. Thus, we show that the effects of sub-chronic ketamine treatment in mice are sub-strain specific.
      PubDate: 2022-11-24T00:00:00Z
  • Corrigendum: An accumulation-of-evidence task using visual pulses for mice
           navigating in virtual reality

    • Authors: Lucas Pinto, Sue A. Koay, Ben Engelhard, Alice M. Yoon, Ben Deverett, Stephan Y. Thiberge, Ilana B. Witten, David W. Tank, Carlos D. Brody
      PubDate: 2022-11-22T00:00:00Z
  • Using deep learning to study emotional behavior in rodent models

    • Authors: Jessica Y. Kuo, Alexander J. Denman, Nicholas J. Beacher, Joseph T. Glanzberg, Yan Zhang, Yun Li, Da-Ting Lin
      Abstract: Quantifying emotional aspects of animal behavior (e.g., anxiety, social interactions, reward, and stress responses) is a major focus of neuroscience research. Because manual scoring of emotion-related behaviors is time-consuming and subjective, classical methods rely on easily quantified measures such as lever pressing or time spent in different zones of an apparatus (e.g., open vs. closed arms of an elevated plus maze). Recent advancements have made it easier to extract pose information from videos, and multiple approaches for extracting nuanced information about behavioral states from pose estimation data have been proposed. These include supervised, unsupervised, and self-supervised approaches, employing a variety of different model types. Representations of behavioral states derived from these methods can be correlated with recordings of neural activity to increase the scope of connections that can be drawn between the brain and behavior. In this mini review, we will discuss how deep learning techniques can be used in behavioral experiments and how different model architectures and training paradigms influence the type of representation that can be obtained.
      PubDate: 2022-11-22T00:00:00Z
  • Exposure to soiled bedding reduces abnormal repetitive behaviors in mice

    • Authors: Karin Müller, Theresia Lengheimer, Julia B. Kral-Pointner, Johann Wojta, Lusine Yeghiazaryan, Christoph Krall, Rupert Palme, Sonia Kleindorfer, Roberto Plasenzotti, Daniela D. Pollak, Katharina E. Tillmann
      Abstract: Hygiene management protocols in laboratory mouse husbandries worldwide most commonly employ soiled bedding-exposed sentinel mice to monitor the occurrence of infections in mouse colonies. Using this approach, sentinel mice repeatedly receive a mixture of used bedding, supplied by a variety of cages of a defined hygienic unit for a period of several months. Hereby, microorganisms shed in the used bedding can infect the sentinel animals and can be detected in subsequent health monitoring procedures. However, murine excrements carry more than only microorganisms. Mouse feces and urine also contain a multitude of olfactory molecules, which the animals use to code information about social status and context. However, if and how the persistent and repeated experience with these odor cues affects the behavior of sentinel mice, has not yet been explored. To address this question, we conducted a longitudinal study for neurochemical output parameters related to an organism’s responsiveness to challenging conditions, and for the exploratory assessment of a panel of home cage behaviors in soiled bedding and control female C57BL/6J mice. We found that the number of mice showing abnormal repetitive behaviors, including barbering and bar mouthing, was lower in the soiled bedding group. While neutrophil/lymphocyte ratios and fecal corticosterone metabolites did not differ between groups, the within-group variance of the neutrophil/lymphocyte ratio was reduced in the soiled bedding group. These results show that the occurrence of abnormal repetitive behaviors is lower in sentinel than in control mice and suggest a beneficial effect of soiled bedding on the welfare of laboratory mice and on outcome variability.
      PubDate: 2022-11-22T00:00:00Z
  • The role of the bed nucleus of the stria terminalis in the motivational
           control of instrumental action

    • Authors: Miao Ge, Bernard W. Balleine
      Abstract: We review recent studies assessing the role of the bed nucleus of the stria terminalis (BNST) in the motivational control of instrumental conditioning. This evidence suggests that the BNST and central nucleus of the amygdala (CeA) form a circuit that modulates the ventral tegmental area (VTA) input to the nucleus accumbens core (NAc core) to control the influence of Pavlovian cues on instrumental performance. In support of these claims, we found that activity in the oval region of BNST was increased by instrumental conditioning, as indexed by phosphorylated ERK activity (Experiment 1), but that this increase was not due to exposure to the instrumental contingency or to the instrumental outcome per se (Experiment 2). Instead, BNST activity was most significantly incremented in a test conducted when the instrumental outcome was anticipated but not delivered, suggesting a role for BNST in the motivational effects of anticipated outcomes on instrumental performance. To test this claim, we examined the effect of NMDA-induced cell body lesions of the BNST on general Pavlovian-to-instrumental transfer (Experiment 3). These lesions had no effect on instrumental performance or on conditioned responding during Pavlovian conditioning to either an excitory conditioned stimulus (CS) or a neutral CS (CS0) but significantly attenuated the excitatory effect of the Pavlovian CS on instrumental performance. These data are consistent with the claim that the BNST mediates the general excitatory influence of Pavlovian cues on instrumental performance and suggest BNST activity may be central to CeA-BNST modulation of a VTA-NAc core circuit in incentive motivation.
      PubDate: 2022-11-21T00:00:00Z
  • Editorial: Stress, anxiety, and the synapse

    • Authors: Kristin L. Gosselink, Jorge A. Sierra Fonseca, Daniela Jezova
      PubDate: 2022-11-21T00:00:00Z
  • Trends of Tourette Syndrome in children from 2011 to 2021: A bibliometric
           analysis|Objective|Materials and methods|Results|Conclusion

    • Authors: Cuiling Yang, Jie Zhang, Qiong Zhao, Jingjin Zhang, Jiang Zhou, Li Wang
      Abstract: ObjectiveAnalyze the research status of Tourette Syndrome (TS) in children by CiteSpace and determine the current research hotspots and frontiers.Materials and methodsWe chose publications indexed in the Web of Science Core Collection (WoSCC) database for studies related to TS in children from 2011 to 2021. We built online cooperation maps of countries/regions, institutions, authors, journals, references, and keywords by CiteSpace, and identified hotspots and frontiers of study for children’s TS.ResultsA total of 1,232 publications about TS in children were downloaded from the WoSCC. The USA (414) was the country with the highest rate of production, and University College London (87) was the institution that had the highest publication rate. Andrea Eugenio Cavanna was the most prolific author (39 papers). There was inactive cooperation between institutions, countries/regions, and authors. The Journal of European Child & Adolescent Psychiatry was the most active journal. Hot topics focused on epidemiology, comorbidities, deep brain stimulation, behavioral therapy, basal ganglia, pharmacological treatment, and risk factors of TS in children.ConclusionAccording to the CiteSpace results, this study found that authors, countries/regions, and institutions were not actively working together. Current research hotspots mainly consist of epidemiology, comorbidities, deep brain stimulation, behavior therapy, and basal ganglia. The main research trends include comorbidities, pharmacological treatment, and risk factors. Therefore, international cooperation should be strengthened in the future, and it should be mindful of the psychiatric comorbidities of TS, the choice of intervention measures, and early warning of risk factors.
      PubDate: 2022-11-17T00:00:00Z
  • Neural cue reactivity is not stronger in male than in female patients with
           alcohol use disorder|Background|Methods|Results|Conclusion

    • Authors: Sarah Gerhardt, Sabine Hoffmann, Haoye Tan, Martin Fungisai Gerchen, Peter Kirsch, Sabine Vollstädt-Klein, Falk Kiefer, Patrick Bach, Bernd Lenz
      Abstract: BackgroundMales consume more alcohol than females, and alcohol use disorder (AUD) is more prevalent in males than females. However, females progress faster to AUD. Sex differences in neural alcohol cue reactivity were previously observed in young social drinkers, indicating a role of hypersensitivity to alcohol-related cues in very early stages of addiction. To our knowledge, this is the first study on patients diagnosed with AUD to test sex differences in neural reactivity to alcohol cues in order to widen previous findings.MethodsWe analyzed data from previous studies, using a well-established functional magnetic resonance imaging (fMRI) paradigm to compare neural reactivity to alcohol cues between 42 female and 124 male patients with AUD (mean age 45 and 46 years) in predefined regions of interest that were implicated by previous studies (ventral and dorsal striatum as well as caudate, putamen, amygdala, hippocampus, insula, anterior cingulate cortex, and medial prefrontal cortex) using independent samples t-tests. Post-hoc, effect size calculations were performed.ResultsThroughout all nine regions of interest, we found no statistically significant sex differences in neural reactivity toward alcoholic pictures alone or in comparison to neutral pictures (p > 0.05, FDR-corrected). Post-hoc effect size estimates indicated a magnitude between 0.137 and 0.418 (Hedge’s g) on alcohol reactivity to alcohol cues compared to neutral cues and indicate very small to less than medium effect sizes in the direction of higher cue reactivity in female patients.ConclusionPrevious studies showed sex differences in neural alcohol cue reactivity in younger social and problematic alcohol drinkers, i.e., stronger striatal cue-reactivity in males. After correction for multiple comparisons, we did not observe significant sex differences in a cohort of middle-aged females and males with AUD. Sex differences that are present during early phases of addiction development might disappear at later stages of AUD and might thus be considered as clinically less relevant in patients with more severe AUD.
      PubDate: 2022-11-16T00:00:00Z
  • Stress-induced impairment reveals the stage and features of post-error
           adaptive adjustment

    • Authors: Na Hu, Quanshan Long, Dawei Zhang, Xiaoxi Wang, Min Deng, Qing Li, Minmin Yan, Antao Chen
      Abstract: An increased reaction time often occurs after error responses (post-error slowing, PES). However, the role of top-down regulation in post-error processing remains to be debated. Impairing cognitive control function through acute stress would help to investigate the role and stage of top-down adaptive regulation in post-error processing. Here, we recruited 50 healthy male participants who were randomly assigned to either a stress condition (Trier Social Stress Task, TSST) or a control condition (control version of the TSST). A color-word Stroop task with different response stimulus intervals (RSIs) was used to investigate the effects of acute stress on different stages of post-error processing. The results showed that cortisol, heart rate, perceived stress level, and negative affect were higher in the stress group (n = 24) than in the control group (n = 26), indicating successful stress induction. The accuracy of post-error response in the control group increased with the extension of RSI, and the reaction time decreased. However, the accuracy of 1,200 ms RSI was close to that of 700 ms RSI in the stress group but was significantly lower than that in the control group. The results suggested that acute stress caused the impairment of top-down adaptive regulation after error. Furthermore, our study manifested adaptive adjustment only in the late stages of post-error processing, indicating the phasic and adaptive features of post-error adjustment.
      PubDate: 2022-11-10T00:00:00Z
  • Fear conditioning in invertebrates

    • Authors: Amy K. Pribadi, Sreekanth H. Chalasani
      Abstract: Learning to identify and predict threats is a basic skill that allows animals to avoid harm. Studies in invertebrates like Aplysia californica, Drosophila melanogaster, and Caenorhabditis elegans have revealed that the basic mechanisms of learning and memory are conserved. We will summarize these studies and highlight the common pathways and mechanisms in invertebrate fear-associated behavioral changes. Fear conditioning studies utilizing electric shock in Aplysia and Drosophila have demonstrated that serotonin or dopamine are typically involved in relaying aversive stimuli, leading to changes in intracellular calcium levels and increased presynaptic neurotransmitter release and short-term changes in behavior. Long-term changes in behavior typically require multiple, spaced trials, and involve changes in gene expression. C. elegans studies have demonstrated these basic aversive learning principles as well; however, fear conditioning has yet to be explicitly demonstrated in this model due to stimulus choice. Because predator–prey relationships can be used to study learned fear in a naturalistic context, this review also summarizes what is known about predator-induced behaviors in these three organisms, and their potential applications for future investigations into fear conditioning.
      PubDate: 2022-11-10T00:00:00Z
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