A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z  

  First | 1 2 3 4 5 6        [Sort by number of followers]   [Restore default list]

  Subjects -> PSYCHOLOGY (Total: 1007 journals)
Showing 601 - 174 of 174 Journals sorted alphabetically
Nigerian Journal of Guidance and Counselling     Full-text available via subscription   (Followers: 2)
Nordic Psychology     Hybrid Journal  
O Que Nos Faz Pensar : Cadernos do Departamento de Filosofia da PUC-Rio     Open Access  
OA Autism     Open Access   (Followers: 3)
Occupational Health Science     Hybrid Journal  
Online Readings in Psychology and Culture     Open Access  
Open Journal of Medical Psychology     Open Access  
Open Mind     Open Access   (Followers: 1)
Open Neuroimaging Journal     Open Access  
Open Psychology Journal     Open Access  
Organisational and Social Dynamics: An International Journal of Psychoanalytic, Systemic and Group Relations Perspectives     Full-text available via subscription   (Followers: 5)
Organizational Psychology Review     Hybrid Journal   (Followers: 16)
Orientación y Sociedad : Revista Internacional e Interdisciplinaria de Orientación Vocacional Ocupacional     Open Access  
Paidéia (Ribeirão Preto)     Open Access  
Pain     Hybrid Journal   (Followers: 60)
Papeles del Psicólogo     Open Access  
Pastoral Psychology     Hybrid Journal   (Followers: 3)
Peace and Conflict : Journal of Peace Psychology     Full-text available via subscription   (Followers: 6)
Pensamiento Psicologico     Open Access  
Pensando Familias     Open Access  
Pensando Psicología     Open Access  
People and Animals : The International Journal of Research and Practice     Open Access  
Perception     Full-text available via subscription   (Followers: 13)
Perceptual and Motor Skills     Full-text available via subscription   (Followers: 8)
Persona     Open Access  
Persona : Jurnal Psikologi Indonesia     Open Access  
Persona Studies     Open Access  
Personality and Social Psychology Bulletin     Hybrid Journal   (Followers: 139)
Personality and Social Psychology Review     Hybrid Journal   (Followers: 48)
Personality Disorders: Theory, Research, and Treatment     Full-text available via subscription   (Followers: 18)
Personnel Assessment and Decisions     Open Access  
Personnel Psychology     Hybrid Journal   (Followers: 54)
Perspectives interdisciplinaires sur le travail et la santé     Open Access   (Followers: 3)
Perspectives on Behavior Science     Hybrid Journal  
Perspectives On Psychological Science     Hybrid Journal   (Followers: 36)
Perspectives Psy     Full-text available via subscription   (Followers: 2)
Phenomenology & Practice     Open Access   (Followers: 2)
Phenomenology and the Cognitive Sciences     Hybrid Journal   (Followers: 4)
Philosophical Psychology     Hybrid Journal   (Followers: 19)
Philosophy, Psychiatry, & Psychology     Full-text available via subscription   (Followers: 11)
Physiology & Behavior     Hybrid Journal   (Followers: 14)
physiopraxis     Hybrid Journal  
PiD - Psychotherapie im Dialog     Hybrid Journal   (Followers: 1)
Policy Insights from the Behavioral and Brain Sciences     Full-text available via subscription   (Followers: 4)
Political Psychology     Hybrid Journal   (Followers: 42)
Porn Studies     Hybrid Journal   (Followers: 6)
PPmP - Psychotherapie Psychosomatik Medizinische Psychologie     Hybrid Journal   (Followers: 1)
Practice Innovations     Full-text available via subscription  
Pragmatic Case Studies in Psychotherapy     Open Access   (Followers: 1)
Pratiques Psychologiques     Full-text available via subscription  
Praxis der Kinderpsychologie und Kinderpsychiatrie     Hybrid Journal  
Problems of Psychology in the 21st Century     Open Access  
Professional Psychology : Research and Practice     Full-text available via subscription   (Followers: 6)
Progress in Brain Research     Full-text available via subscription   (Followers: 2)
Psic : Revista de Psicologia da Vetor Editora     Open Access  
Psico     Open Access  
Psicoanalisi     Full-text available via subscription  
Psicobiettivo     Full-text available via subscription  
Psicoespacios     Open Access  
Psicogente     Open Access  
Psicol?gica Journal     Open Access  
Psicologia     Open Access  
Psicologia     Open Access  
Psicologia : Teoria e Pesquisa     Open Access  
Psicologia : Teoria e Prática     Open Access  
Psicologia da Educação     Open Access  
Psicologia della salute     Full-text available via subscription  
Psicología desde el Caribe     Open Access  
Psicologia di Comunità. Gruppi, ricerca-azione, modelli formativi     Full-text available via subscription  
Psicologia e Saber Social     Open Access   (Followers: 1)
Psicologia e Saúde em Debate     Open Access  
Psicologia em Pesquisa     Open Access  
Psicologia em Revista     Open Access  
Psicologia Ensino & Formação     Open Access  
Psicologia Hospitalar     Open Access  
Psicologia Iberoamericana     Open Access   (Followers: 1)
Psicologia para América Latina     Open Access  
Psicologia USP     Open Access   (Followers: 1)
Psicología, Conocimiento y Sociedad     Open Access  
Psicologia, Saúde e Doenças     Open Access  
Psicooncología     Open Access   (Followers: 1)
Psicoperspectivas     Open Access  
Psicoterapia e Scienze Umane     Full-text available via subscription  
Psikis : Jurnal Psikologi Islami     Open Access  
Psikohumaniora : Jurnal Penelitian Psikologi     Open Access  
Psisula : Prosiding Berkala Psikologi     Open Access  
Psocial : Revista de Investigación en Psicología Social     Open Access  
Psych     Open Access   (Followers: 1)
PsyCh Journal     Hybrid Journal   (Followers: 2)
PSYCH up2date     Hybrid Journal   (Followers: 2)
Psych. Pflege Heute     Hybrid Journal   (Followers: 1)
Psychê     Open Access  
Psyche: A Journal of Entomology     Open Access   (Followers: 6)
Psychiatrie et violence     Open Access  
Psychiatrie und Psychotherapie up2date     Hybrid Journal   (Followers: 2)
Psychiatrische Praxis     Hybrid Journal   (Followers: 1)
Psychiatry, Psychology and Law     Hybrid Journal   (Followers: 354)
Psychoanalysis and History     Hybrid Journal   (Followers: 3)
Psychoanalysis, Self and Context     Hybrid Journal   (Followers: 4)
Psychoanalytic Dialogues: The International Journal of Relational Perspectives     Hybrid Journal   (Followers: 8)
Psychoanalytic Inquiry: A Topical Journal for Mental Health Professionals     Hybrid Journal   (Followers: 7)
Psychoanalytic Perspectives     Hybrid Journal   (Followers: 6)
Psychoanalytic Psychology     Full-text available via subscription   (Followers: 3)
Psychoanalytic Psychotherapy     Hybrid Journal   (Followers: 13)
Psychoanalytic Review The     Full-text available via subscription   (Followers: 7)
Psychoanalytic Social Work     Hybrid Journal   (Followers: 10)
Psychoanalytic Study of the Child     Hybrid Journal   (Followers: 1)
Psychodynamic Practice: Individuals, Groups and Organisations     Hybrid Journal   (Followers: 6)
Psychodynamic Psychiatry     Full-text available via subscription   (Followers: 8)
Psychogeriatrics     Hybrid Journal   (Followers: 1)
Psychologia : Advances de la Disciplina     Open Access  
Psychologica     Open Access  
Psychologica Belgica     Open Access   (Followers: 1)
Psychological Assessment     Full-text available via subscription   (Followers: 12)
Psychological Bulletin     Full-text available via subscription   (Followers: 193)
Psychological Medicine     Hybrid Journal   (Followers: 19)
Psychological Perspectives: A Semiannual Journal of Jungian Thought     Hybrid Journal   (Followers: 1)
Psychological Reports     Hybrid Journal  
Psychological Research     Hybrid Journal   (Followers: 9)
Psychological Research on Urban Society     Open Access  
Psychological Review     Full-text available via subscription   (Followers: 175)
Psychological Science     Hybrid Journal   (Followers: 237)
Psychological Science and Education     Open Access   (Followers: 1)
Psychological Science and Education psyedu.ru     Open Access   (Followers: 1)
Psychological Science In the Public Interest     Hybrid Journal   (Followers: 17)
Psychological Studies     Hybrid Journal   (Followers: 3)
Psychological Thought     Open Access   (Followers: 2)
Psychological Trauma: Theory, Research, Practice, and Policy     Full-text available via subscription   (Followers: 20)
Psychologie Clinique     Full-text available via subscription  
Psychologie du Travail et des Organisations     Hybrid Journal  
Psychologie Française     Full-text available via subscription  
Psychologie in Erziehung und Unterricht     Full-text available via subscription   (Followers: 2)
Psychologische Rundschau     Hybrid Journal   (Followers: 2)
Psychology     Open Access   (Followers: 6)
Psychology     Open Access  
Psychology & Health     Hybrid Journal   (Followers: 32)
Psychology & Sexuality     Hybrid Journal   (Followers: 15)
Psychology and Aging     Full-text available via subscription   (Followers: 16)
Psychology and Developing Societies     Hybrid Journal  
Psychology and Law     Open Access   (Followers: 3)
Psychology and Psychotherapy: Theory, Research and Practice     Full-text available via subscription   (Followers: 18)
Psychology in Russia: State of the Art     Free   (Followers: 2)
Psychology in Society     Open Access  
Psychology Learning & Teaching     Full-text available via subscription   (Followers: 9)
Psychology of Addictive Behaviors     Full-text available via subscription   (Followers: 15)
Psychology of Aesthetics, Creativity and the Arts     Full-text available via subscription   (Followers: 15)
Psychology of Consciousness : Theory, Research, and Practice     Full-text available via subscription   (Followers: 7)
Psychology of Language and Communication     Open Access   (Followers: 14)
Psychology of Leaders and Leadership     Full-text available via subscription  
Psychology of Learning and Motivation     Full-text available via subscription   (Followers: 11)
Psychology of Men and Masculinity     Full-text available via subscription   (Followers: 24)
Psychology of Music     Hybrid Journal   (Followers: 20)
Psychology of Popular Media Culture     Full-text available via subscription   (Followers: 4)
Psychology of Religion and Spirituality     Full-text available via subscription   (Followers: 16)
Psychology of Sexual Orientation and Gender Diversity     Full-text available via subscription   (Followers: 12)
Psychology of Violence     Full-text available via subscription   (Followers: 16)
Psychology of Well-Being : Theory, Research and Practice     Open Access   (Followers: 20)
Psychology of Women Quarterly     Hybrid Journal   (Followers: 8)
Psychology Research and Behavior Management     Open Access   (Followers: 6)
Psychology, Community & Health     Open Access   (Followers: 3)
Psychology, Crime & Law     Hybrid Journal   (Followers: 27)
Psychology, Health & Medicine     Hybrid Journal   (Followers: 16)
Psychology, Public Policy, and Law     Full-text available via subscription   (Followers: 13)
Psychometrika     Hybrid Journal   (Followers: 7)
Psychomusicology : Music, Mind, and Brain     Full-text available via subscription   (Followers: 5)
Psychoneuroendocrinology     Hybrid Journal   (Followers: 14)
Psychonomic Bulletin & Review     Full-text available via subscription   (Followers: 18)
Psychopathology     Full-text available via subscription   (Followers: 4)
Psychopharmacology     Hybrid Journal   (Followers: 16)
Psychophysiology     Hybrid Journal   (Followers: 7)
psychopraxis. neuropraxis     Hybrid Journal   (Followers: 1)
Psychosis: Psychological, Social and Integrative Approaches     Hybrid Journal   (Followers: 8)
Psychosomatic Medicine     Hybrid Journal   (Followers: 12)
Psychosomatic Medicine and General Practice     Open Access   (Followers: 1)
Psychosomatics     Hybrid Journal   (Followers: 9)
Psychotherapeut     Hybrid Journal   (Followers: 4)
Psychotherapy and Politics International     Hybrid Journal   (Followers: 5)
Psychotherapy and Psychosomatics     Partially Free   (Followers: 11)
Psychotherapy in Australia     Full-text available via subscription   (Followers: 1)
Psychotherapy Research     Hybrid Journal   (Followers: 18)
PsychTech & Health Journal     Open Access   (Followers: 3)
Psyecology - Bilingual Journal of Environmental Psychology     Hybrid Journal   (Followers: 3)
Psyke & Logos     Open Access   (Followers: 4)
Psykhe (Santiago)     Open Access  
Quaderni di Gestalt     Full-text available via subscription  
Quaderns de Psicologia     Open Access  
Qualitative Psychology     Full-text available via subscription   (Followers: 6)
Qualitative Research in Psychology     Hybrid Journal   (Followers: 17)
Qualitative Studies     Open Access   (Followers: 12)
Quality and User Experience     Hybrid Journal   (Followers: 2)
Quantitative Methods for Psychology     Open Access   (Followers: 1)
Quarterly Journal of Experimental Psychology     Hybrid Journal   (Followers: 22)
Race and Social Problems     Hybrid Journal   (Followers: 10)
Reading Psychology     Hybrid Journal   (Followers: 6)
Rehabilitation Psychology     Full-text available via subscription   (Followers: 9)
Religion, Brain & Behavior     Hybrid Journal   (Followers: 10)
Research in Autism Spectrum Disorders     Hybrid Journal   (Followers: 26)
Research in Psychology and Behavioral Sciences     Open Access   (Followers: 2)
Research in Psychotherapy : Psychopathology, Process and Outcome     Open Access   (Followers: 2)
Reverso     Open Access  

  First | 1 2 3 4 5 6        [Sort by number of followers]   [Restore default list]

Similar Journals
Journal Cover
Psychopharmacology
Number of Followers: 16  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1432-2072 - ISSN (Online) 0033-3158
Published by Springer-Verlag Homepage  [2469 journals]
  • Editorial Expression of Concern: Histamine- and haloperidol-induced
           catalepsy in aged mice: differential responsiveness to l-DOPA

    • Free pre-print version: Loading...

      PubDate: 2022-05-21
       
  • Editorial Expression of Concern: Synergistic anticataleptic effect of
           imipramine and nicotine in a rotenone-induced rat model

    • Free pre-print version: Loading...

      PubDate: 2022-05-21
       
  • Editorial Expression of Concern: Anticataleptic activity of nicotine in
           rats: involvement of the lateral entorhinal cortex

    • Free pre-print version: Loading...

      PubDate: 2022-05-21
       
  • Editorial Expression of Concern: Somatostatin antagonist induces catalepsy
           in the aged rat

    • Free pre-print version: Loading...

      PubDate: 2022-05-21
       
  • Sex and drug differences in stress, craving and cortisol response to the
           trier social stress task

    • Free pre-print version: Loading...

      Abstract: Rationale The hypothalamic–pituitary–adrenal (HPA) axis is a critical hormonal system involved in stress response. A number of studies have investigated the HPA axis response of drug-dependent individuals to stressors. Stress-induced vulnerabilities in the HPA axis may differ in response to chronic use of different substances, possibly leading to different target therapies. There has not been a direct comparison of HPA axis and subjective response between individuals with different types of substance use disorders following a laboratory stress intervention. Objectives The primary goal of the current study was to compare subjective and neuroendocrine response to the Trier Social Stress Task (TSST) across multiple primary types of substance use disorders and investigate differential response between males and females. Methods Four hundred participants were drawn from seven studies completed at the Medical University of South Carolina between 2011 and 2021. The TSST was utilized across studies and subjective and neuroendocrine responses measured following completion. Generalized linear mixed effects models and area under the response curve analysis were used to compare both substance type and sex differences. Results The study groups involving individuals with cocaine use disorder had blunted stress, craving and cortisol response following the TSST as compared to other substance use groups. Females in the cocaine groups reported higher subjective stress but lower cortisol than males. Conclusions The study results indicate that there may be differential effects of substances on the HPA axis, with cocaine using individuals exhibiting more blunting of the HPA axis response as compared to users of other substances.
      PubDate: 2022-05-20
       
  • PP2A-associated tau hyperphosphorylation was involved in sevoflurane
           induced neonatal neurotoxicity

    • Free pre-print version: Loading...

      Abstract: Background The effects of sevoflurane anesthesia on childhood neurodevelopment and adult brain function have attracted increasing scientific attentions. However, the exact mechanisms underlying hyperphosphorylation of tau protein in sevoflurane induced abnormalities in central nervous system (CNS) development, particularly in the hippocampus, have not been fully determined. Methods We utilized molecular biological and behavioral approaches to compare the changes in cognitive function in mice exposed to repeated sevoflurane during the neonatal stage, and to assess whether PP2A-associated tau hyperphosphorylation is involved in sevoflurane induced neonatal neurotoxicity. Results We reported that mice anesthetized with repeated sevoflurane during the neonatal period caused cognitive dysfunction during the adulthood. More importantly, we found that hyperphosphorylation of tau protein and decreased level of protein phosphatase 2A (PP2A) were detected in the hippocampus of mice after neonatal exposure of sevoflurane. Meanwhile, GSK-3β activity was found to be increased with repeated sevoflurane exposure, but not for more than 2 weeks. Conclusion Our results suggest that PP2A-associated hyperphosphorylation of tau protein might contribute to sevoflurane induced developmental neurotoxicity. These findings could provide a theoretical basis for the safely usage of sevoflurane in pediatric surgeries, and offer a valuable reference and potential therapeutic targets for the development of neuroprotective drugs.
      PubDate: 2022-05-17
       
  • Development of pulsed intravenous nicotine infusions as a model for
           inhaled nicotine in humans

    • Free pre-print version: Loading...

      Abstract: Rationale Although nicotine from cigarettes is delivered in puff-sized amounts, most preclinical and human intravenous (IV) nicotine studies have used bolus or continuous infusions. Objectives To determine the feasibility of a pulsed-nicotine infusion model in smokers. Methods Following overnight abstinence, 12 adult smokers underwent 5 laboratory sessions. Using a crossover design, in each session, participants were assigned to 1 of 5 conditions: (1) high/fast: 1.0 mg nicotine delivered over 5 pulsed-infusions, then 15 saline infusions; (2) high/slow: 1.0 mg nicotine delivered over 20 pulsed-infusions; (3) low/fast: 0.2 mg nicotine delivered over 5 pulsed-infusions, then 15 saline infusions; (4) low/slow: 0.2 mg nicotine delivered over 20 pulsed-infusions; and (5) placebo: Saline delivered over 20 pulsed-infusions. Subjective drug effects, urges to smoke, nicotine withdrawal, and cognitive performance were measured in each session. Results Both the high/fast and high/slow conditions were associated with greater “head rush” and “high” (p < 0.05). The high/fast condition also provided greater suppression of urges to smoke and nicotine withdrawal (p < 0.05), indexed by the Questionnaire of Urges to Smoke-Brief, and the Minnesota Nicotine Withdrawal Scale, respectively. The high/fast and high/slow conditions produced greater increases in heart rate (p < 0.01) than saline. Finally, there were no main effects of dosing conditions on cognitive performance, indexed by the continuous performance test. Conclusions These findings demonstrate the feasibility of pulsed-nicotine infusions to model nicotine delivery by smoking. This model could inform future studies testing novel smoking cessation therapies and tobacco regulatory studies testing the impact of nicotine reduction approaches.
      PubDate: 2022-05-13
       
  • Acute tryptophan depletion alters affective touch perception

    • Free pre-print version: Loading...

      Abstract: Rationale Affiliative tactile interactions help regulate physiological arousal and confer resilience to acute and chronic stress. C-tactile afferents (CTs) are a population of unmyelinated, low threshold mechanosensitive cutaneous nerve fibres which respond optimally to a low force stimulus, moving at between 1 and 10 cm/s. As CT firing frequencies correlate positively with subjective ratings of touch pleasantness, they are hypothesised to form the first stage of encoding affiliative tactile interactions. Serotonin is a key modulator of social responses with known effects on bonding. Objectives The aim of the present study was to determine the effect of acutely lowering central serotonin levels on perceptions of CT-targeted affective touch. Methods In a double blind, placebo-controlled design, the effect of acute tryptophan depletion (ATD) on 25 female participants’ ratings of directly and vicariously experienced touch was investigated. Psychophysical techniques were used to deliver dynamic tactile stimuli; some velocities were targeted to optimally activate CTs (1–10 cm/s), whereas other, faster and slower strokes fell outside the CT optimal range. Discriminative tactile function, cold pain threshold and tolerance were also measured. Results ATD significantly increased pleasantness ratings of both directly and vicariously experienced affective touch, increasing discrimination of the specific hedonic value of CT targeted velocities. While ATD had no effect on either tactile or cold pain thresholds, there was a trend for reduced tolerance to cold pain. Conclusions These findings are consistent with previous reports that depletion of central serotonin levels modulates neural and behavioural responsiveness to appetitive sensory signals.
      PubDate: 2022-05-12
       
  • Glibenclamide alters serotonin and dopamine levels in the rat striatum and
           hippocampus, reducing cognitive impairment

    • Free pre-print version: Loading...

      Abstract: Rationale Glibenclamide (GD) is a widely used medical drug; therefore, identifying the mechanisms underlying its pleiotropic effects in the central nervous system is urgent. Objectives The aim of this work was to determine the ability of GD to modulate serotonin (5-hydroxytryptamine, 5-HT) and dopamine (DA) transmission and to assess the dose-dependent effect of GD on cognitive function in rats during natural ageing. Methods In Experiment 1, rats received 10, 25, or 50 μg/kg GD intraperitoneally for 10 days. In Experiment 2, rats received 50 μg/kg GD intraperitoneally for 30 days. Spatial and working memory was assessed in the MWM and Y-maze tests, respectively. In both experiments, the levels of DA and 5-HT, their metabolites, and turnover rate were analysed by HPLC-ED in the rat hippocampus and striatum. Results Changes in DA and 5-HT levels occurred only with a dose of 50 μg/kg GD. Therefore, in the second experiment, we administered a dose of 50 μg/kg GD. At this dose, GD prevented the development of impairments in spatial and working memory. The hippocampal concentrations of DA and DOPAC decreased, and the striatal concentrations of DA, DOPAC, 5-HT, and 5-HIAA increased. Conclusion One of the possible mechanisms of the precognitive effect of GD is its ability to modulate monoamine transmission. Thus, in translating our results to humans, GD can be recommended as a prophylactic agent for natural ageing to reduce the risk of developing cognitive impairments.
      PubDate: 2022-05-11
       
  • Correction to: Psychedelics: Old trips, new destinations in
           psychopharmacology research

    • Free pre-print version: Loading...

      PubDate: 2022-05-11
       
  • Effects of alcohol hangover on attentional resources during a verbal
           memory/psychomotor tracking dual attention task

    • Free pre-print version: Loading...

      Abstract: Background Alcohol hangover (AH) is associated with impaired attention and memory performance. However, whether this effect is related to reduced attentional resources remains unclear. Aims A dual-attention paradigm was employed to assess the effects of AH on attentional resources, delayed memory recognition, and the interaction between attentional load and AH. Mental effort and perceived performance during AH and control conditions were also assessed. Methods A seminaturalistic, crossover design was used. In total, 25 healthy social drinkers aged 18–35 years, visited the laboratory following a typical night out drinking (Hangover condition) and after alcohol abstinence (control) between 8:30 am and 12:30 pm, with conditions counterbalanced. Attentional load was manipulated via the presence (dual attention) or absence of psychomotor tracking during verbal memory encoding. Perceived mental effort and performance were measured using the NASA-TLX. Participants’ recollected alcohol consumption was used to compute estimated blood alcohol level (eBAC). Results Compared with the control visit, AH was associated with reduced recognition accuracy (particularly more false negatives), higher “tracking costs” (poorer accuracy) in the dual attention condition, increased ratings of “mental demand,” “effort,” and “frustration,” and lower ratings of task performance. There was also a significant main effect of attentional load with poorer recognition accuracy and response time in the dual attention condition. There were no significant interaction effects between hangover and attentional load. Conclusion These findings suggest that reduced attentional resources contribute to the cognitive deficits associated with AH including impaired memory consolidation. They further suggest that while hungover, participants are aware of these deficits but are unable to compensate.
      PubDate: 2022-05-11
       
  • Histamine H3 receptor antagonist, ciproxifan, alleviates cognition and
           synaptic plasticity alterations in a valproic acid-induced animal model of
           autism

    • Free pre-print version: Loading...

      Abstract: Rationale Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and cognitive behaviors. Histamine H3 receptor (H3R) antagonists are considered as therapeutic factors for treating cognitive impairments. Objectives The aim of the present study was to evaluate the effects of the H3R antagonist, ciproxifan (CPX), on cognition impairment especially, spatial learning memory, and synaptic plasticity in the CA1 region of the hippocampus in autistic rats. Methods Pregnant rats were injected with either valproic acid (VPA) (600 mg/kg, i.p.) or saline on an embryonic day 12.5 (E12.5). The effects of the H3R antagonist, ciproxifan (CPX) (1, 3 mg/kg, i.p.), were investigated on learning and memory in VPA-exposed rat pups and saline-exposed rat pups using Morris water maze (MWM) and social interaction tasks. The H2R antagonist, famotidine (FAM) (10, 20, 40 mg/kg, i.p.), was used to determine whether brain histaminergic neurotransmission exerted its procognitive effects through the H2R. In addition, synaptic reinforcement was evaluated by in vivo field potential recording. Results The results showed that VPA-exposed rat pups had significantly lower sociability and social memory performance compared to the saline rats. VPA-exposed rat pups exhibited learning and memory impairments in the MWM task. In addition, VPA caused suppression of long-term potentiation (LTP) in the CA1 area of the hippocampus. Our results demonstrated that CPX 3 mg/kg improved VPA-induced cognitive impairments and FAM 20 mg/kg attenuated cognitive behaviors as well as electrophysiological properties. Conclusions CPX 3 mg/kg improved VPA-induced impairments of LTP as well as learning and memory deficits through H2R.
      PubDate: 2022-05-11
       
  • Inactivation of the thalamic paraventricular nucleus promotes place
           preference and sucrose seeking in male rats

    • Free pre-print version: Loading...

      Abstract: Rationale The experience of reward entails both positive affect and motivation. While the brain regions responsible for these distinct aspects of reward are dissociable from each other, the paraventricular nucleus of the thalamus (PVT) may play a role in both. Objectives To investigate the role of the PVT in both affect and motivation, and to identify neuropeptides that might mediate these effects. Methods Male rats were tested for conditioned place preference following temporary inactivation of the anterior or posterior PVT with local injections of the GABAB and GABAA agonists, baclofen + muscimol. They were tested for sucrose seeking under a fixed ratio 3 (FR3) schedule of reinforcement and after extinction, following injection into the posterior PVT of baclofen + muscimol or saline vehicle. Finally, quantitative real-time PCR was used to examine local neuropeptide gene expression following injection into the posterior PVT of baclofen + muscimol or saline vehicle. Results Conditioned place preference was induced by temporary inactivation of the posterior but not anterior PVT. While sucrose seeking under an FR3 schedule of reinforcement was unaffected by inactivation of the posterior PVT, reinstatement of sucrose seeking was promoted by posterior PVT inactivation. Local gene expression of pituitary adenylate cyclase–activating polypeptide (PACAP), but not enkephalin or neurotensin, was reduced following inactivation of the posterior PVT. Conclusions Temporary inactivation of the posterior PVT affects both affect and motivation as well as local gene expression of PACAP. These results suggest that the posterior PVT is one brain region that may participate in both major aspects of reward.
      PubDate: 2022-05-07
       
  • Spatial frequency processing and its modulation by emotional content in
           severe alcohol use disorder

    • Free pre-print version: Loading...

      Abstract: Rationale Visuo-perceptive deficits in severe alcohol use disorder (SAUD) remain little understood, notably regarding the respective involvement of the two main human visual streams, i.e., magnocellular (MC) and parvocellular (PC) pathways, in these deficits. Besides, in healthy populations, low-level visual perception can adapt depending on the nature of visual cues, among which emotional features, but this MC and PC pathway adaptation to emotional content is unexplored in SAUD. Objectives To assess MC and PC functioning as well as their emotional modulations in SAUD. Methods We used sensitivity indices (d′) and repeated-measures analyses of variance to compare orientation judgments of Gabor patches sampled at various MC- and PC-related spatial frequencies in 35 individuals with SAUD and 38 matched healthy controls. We then explored how emotional content modulated performances by introducing neutral or fearful face cues immediately before the Gabor patches and added the type of cue in the analyses. Results SAUD patients showed a general reduction in sensitivity across all spatial frequencies, indicating impoverished processing of both coarse and fine-scale visual content. However, we observed selective impairments depending on facial cues: individuals with SAUD processed intermediate spatial frequencies less efficiently than healthy controls following neutral faces, whereas group differences emerged for the highest spatial frequencies following fearful faces. Altogether, SAUD was associated with mixed MC and PC deficits that may vary according to emotional content, in line with a flexible but suboptimal use of low-level visual content. Such subtle alterations could have implications for everyday life’s complex visual judgments.
      PubDate: 2022-05-06
       
  • An experimental medicine study of the effects of simvastatin on emotional
           processing, reward learning, verbal memory, and inflammation in healthy
           volunteers

    • Free pre-print version: Loading...

      Abstract: Rationale Clinical studies suggest that the highly lipophilic, anti-inflammatory molecule, simvastatin, might be an ideal candidate for drug repurposing in the treatment of depression. The neuropsychological effects of simvastatin are not known, but their ascertainment would have significant translational value about simvastatin’s influence on mood and cognition. Objectives We aimed to investigate the effects of simvastatin on a battery of psychological tests and inflammatory markers in healthy volunteers. Methods Fifty-three healthy subjects were randomly assigned to 7 days of either simvastatin (N = 27) or sucrose-based placebo (N = 26) given in a double-blind fashion. Then, participants were administered questionnaires measuring subjective rates of mood and anxiety, and a battery of tasks assessing emotional processing, reward learning, and verbal memory. Blood samples for C-reactive protein were also collected. Results Compared to placebo, participants on simvastatin showed a higher number of positively valenced intrusions in the emotional recall task (F1,51 = 4.99, p = 0.03), but also an increase in anxiety scores (F1,51 = 5.37, p = 0.02). An exploratory analysis of the females’ subgroup (N = 27) showed lower number of misclassifications as sad facial expression in the simvastatin arm (F1,25 = 6.60, p = 0.02). No further statistically significant changes could be observed on any of the other outcomes measured. Conclusions We found limited evidence that 7-day simvastatin use in healthy volunteer induces a positive emotional bias while also being associated with an increase in anxiety, potentially reflecting the early effects of antidepressants in clinical practice. Such effect might be more evident in female subjects. Different drug dosages, treatment lengths, and sample selection need consideration in further experimental medicine and clinical studies. Trial registration Clinicaltrials.gov: NCT04652089.
      PubDate: 2022-05-05
       
  • Do psychedelics change beliefs'

    • Free pre-print version: Loading...

      Abstract: Abstract Renewed interest in psychedelics has reignited the debate about whether and how they change human beliefs. In both the clinical and social-cognitive domains, psychedelic consumption may be accompanied by profound, and sometimes lasting, belief changes. We review these changes and their possible underlying mechanisms. Rather than inducing de novo beliefs, we argue psychedelics may instead change the impact of affect and of others’ suggestions on how beliefs are imputed. Critically, we find that baseline beliefs (in the possible effects of psychedelics, for example) might color the acute effects of psychedelics as well as longer-term changes. If we are to harness the apparent potential of psychedelics in the clinic and for human flourishing more generally, these possibilities must be addressed empirically.
      PubDate: 2022-05-04
       
  • Alterations in gut microbiota affect behavioral and inflammatory responses
           to methamphetamine in mice

    • Free pre-print version: Loading...

      Abstract: Rationale and objectives Methamphetamine (METH) is a highly addictive and widely abused drug that causes severe neuroinflammation in the human brain. The gut microbiota has a tremendous impact on the core symptoms of neuropsychiatric disorders via the microbiota-gut-brain (MGB) axis. However, it is not clear whether alterations in the gut microbiota are involved in METH exposure. Methods We established a mouse model with chronic, escalating doses of METH exposure. Intervene in gut microbiota with antibiotics to observe the changes of locomotor activity caused by METH exposure in mice. qPCR and 16S rRNA gene sequencing were used to analyze the gut microbiota profiles. In addition, we tested the levels of inflammatory factors in the nucleus accumbens (NAc), prefrontal cortex (mPFC), hippocampus (HIp), and spleen. Finally, short-chain fatty acids (SCFAs) were supplemented to determine the interaction between behavior changes and the structure of gut microbiota. Results In this research, METH increased the locomotor activity of mice, while antibiotics changed the effect. Antibiotics enhanced the expression of pro-inflammatory cytokines in mPFC, HIp, and spleen of METH-exposed mice. METH altered the gut microbiota of mice after antibiotic treatment, such as Butyricicoccus and Roseburia, which are related to butyrate metabolism. Supplementation with SCFAs changed the behavior of METH-exposed mice and decreased Parabacteroides and increased Lactobacillus in METH-exposed mice gut. Conclusions This research showed that antibiotics affected the behavior of METH-exposed mice and promoted inflammation. Our findings suggest that SCFAs might regulate METH-induced gut microbiota changes and behavior.
      PubDate: 2022-05-03
       
  • Effects of alcohol and task difficulty on visual tracking and
           inattentional blindness

    • Free pre-print version: Loading...

      Abstract: Rationale Inattentional blindness (IB) describes the failure to notice salient but unexpected stimuli in one’s focal visual field. It typically occurs while performing a demanding task (e.g. tracking and counting basketball passes), which consumes attentional resources. Alcohol intoxication is also known to reduce attentional resources, thereby potentially increasing IB and disrupting task performance. Objectives To test the extent to which acute alcohol and task difficulty disrupt counting performance and increase the rate of IB across two experimental tasks. Methods To test the effects of alcohol consumption and task difficulty on IB, we used the Simons and Chabris (Percept 28:1059-1074, 1999) and Simons (2010) “gorilla in our midst” basketball clip in experiment 1 and abstract but analogous stimuli presented in a computerised alternative to that task in experiment 2. Results IB was associated with increased (counting) task difficulty but not alcohol consumption. However, counting accuracy was impaired by both alcohol and increased task difficulty, with the largest detriment being for alcohol participants who noticed the salient but unexpected stimulus. Conclusion The absence of alcohol effects on IB in both experiments was unexpected and warrants further investigation in a field vs lab study comparison and in combination with baseline cognitive measures to test for alcohol expectancy and task compensation effects.
      PubDate: 2022-05-02
       
  • Editorial

    • Free pre-print version: Loading...

      PubDate: 2022-05-01
       
  • Evaluation of the terpenes β-caryophyllene, α-terpineol, and
           γ-terpinene in the mouse chronic constriction injury model of neuropathic
           pain: possible cannabinoid receptor involvement

    • Free pre-print version: Loading...

      Abstract: Abstract Pain is one of the most common reasons to seek medical attention, and chronic pain is a worldwide epidemic. Anecdotal reports suggest cannabis may be an effective analgesic. As cannabis contains the terpenes α-terpineol, β-caryophyllene, and γ-terpinene, we hypothesized these terpenes would produce analgesia in a mouse model of neuropathic pain. We used the chronic constriction injury of the sciatic nerve mouse model, which produces mechanical allodynia, assessed via the von Frey assay, as well as thermal hyperalgesia assessed via the hotplate assay. Compounds were further assessed in tests of locomotor activity, hypothermia, and acute antinociception. Each terpene produced dose-related reversal of mechanical allodynia and thermal hyperalgesia. Thermal hyperalgesia displayed higher sensitivity to the effects of each terpene than mechanical allodynia, and the rank order potency of the terpenes was α-terpineol > β-caryophyllene > γ-terpinene. To examine the involvement of cannabinoid receptors, further tests were conducted in mice lacking either functional cannabinoid type 1 receptors (CB1R (−/−)) or cannabinoid type 2 receptors (CB2R (−/−)). Compared to wild type mice, CB1R (−/−) mice treated with α-terpineol displayed a 2.91-fold decrease in potency to reverse mechanical allodynia; in CB2R (−/−) mice, the potency of α-terpineol was decreased 11.73-fold. The potency of β-caryophyllene to reverse mechanical allodynia decreased 1.80-fold in CB2R (−/−) mice. Each terpene produced a subset of effects in tests of locomotor activity, hypothermia, and acute antinociception. These findings suggest α-terpineol, β-caryophyllene, and γ-terpinene may have differential cannabinoid receptor activity and a pharmacological profile that may yield new efficacious analgesics.
      PubDate: 2022-05-01
       
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
 


Your IP address: 34.204.174.110
 
Home (Search)
API
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-