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Annual Review of Cell and Developmental Biology
Journal Prestige (SJR): 13.473

Citation Impact (citeScore): 17
Number of Followers: 40

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ISSN (Print) 1081-0706 - ISSN (Online) 1081-0706
Published by Annual Reviews

[49 journals]

When We Publish: Accuracy and Quality Control in the Time of Open Access
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  Authors: Ruth Lehmann
  PubDate: 2023-10-16T00:00:00Z
Neofunctionalization of Toll Signaling in Insects: From Immunity to
Dorsoventral Patterning
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  Authors: Siegfried Roth
  Abstract: Toll signaling plays a crucial role in pathogen defense throughout the animal kingdom. It was discovered, however, for its function in dorsoventral (DV) axis formation in Drosophila. In all other insects studied so far, but not outside the insects, Toll is also required for DV patterning. However, in insects more distantly related to Drosophila, Toll's patterning role is frequently reduced and substituted by an expanded influence of BMP signaling, the pathway implicated in DV axis formation in all major metazoan lineages. This suggests that Toll was integrated into an ancestral BMP-based patterning system at the base of the insects or during insect evolution. The observation that Toll signaling has an immune function in the extraembryonic serosa, an early differentiating tissue of most insect embryos, suggests a scenario of how Toll was co-opted from an ancestral immune function for its new role in axis formation.
  PubDate: 2023-10-16T00:00:00Z
The Mexican Tetra, Astyanax mexicanus, as a Model System in Cell and
Developmental Biology
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  Authors: Pavani Ponnimbaduge Perera; David Perez Guerra Misty R. Riddle
  Abstract: Our understanding of cell and developmental biology has been greatly aided by a focus on a small number of model organisms. However, we are now in an era where techniques to investigate gene function can be applied across phyla, allowing scientists to explore the diversity and flexibility of developmental mechanisms and gain a deeper understanding of life. Researchers comparing the eyeless cave-adapted Mexican tetra, Astyanax mexicanus, with its river-dwelling counterpart are revealing how the development of the eyes, pigment, brain, cranium, blood, and digestive system evolves as animals adapt to new environments. Breakthroughs in our understanding of the genetic and developmental basis of regressive and constructive trait evolution have come from A. mexicanus research. They include understanding the types of mutations that alter traits, which cellular and developmental processes they affect, and how they lead to pleiotropy. We review recent progress in the field and highlight areas for future investigations that include evolution of sex differentiation, neural crest development, and metabolic regulation of embryogenesis.
  PubDate: 2023-10-16T00:00:00Z
The Logic of Transgenerational Inheritance: Timescales of Adaptation
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  Authors: Titas Sengupta; Rachel Kaletsky Coleen T. Murphy
  Abstract: Myriad mechanisms have evolved to adapt to changing environments. Environmental stimuli alter organisms’ physiology to create memories of previous environments. Whether these environmental memories can cross the generational barrier has interested scientists for centuries. The logic of passing on information from generation to generation is not well understood. When is it useful to remember ancestral conditions, and when might it be deleterious to continue to respond to a context that may no longer exist' The key might be found in understanding the environmental conditions that trigger long-lasting adaptive responses. We discuss the logic that biological systems may use to remember environmental conditions. Responses spanning different generational timescales employ different molecular machineries and may result from differences in the duration or intensity of the exposure. Understanding the molecular components of multigenerational inheritance and the logic underlying beneficial and maladaptive adaptations is fundamental to understanding how organisms acquire and transmit environmental memories across generations.
  PubDate: 2023-10-16T00:00:00Z
Tissue Biology: In Search of a New Paradigm
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  Authors: Miri Adler; Arun R. Chavan Ruslan Medzhitov
  Abstract: Animal tissues are made up of multiple cell types that are increasingly well-characterized, yet our understanding of the core principles that govern tissue organization is still incomplete. This is in part because many observable tissue characteristics, such as cellular composition and spatial patterns, are emergent properties, and as such, they cannot be explained through the knowledge of individual cells alone. Here we propose a complex systems theory perspective to address this fundamental gap in our understanding of tissue biology. We introduce the concept of cell categories, which is based on cell relations rather than cell identity. Based on these notions we then discuss common principles of tissue modularity, introducing compositional, structural, and functional tissue modules. Cell diversity and cell relations provide a basis for a new perspective on the underlying principles of tissue organization in health and disease.
  PubDate: 2023-10-16T00:00:00Z
Control of Tissue Development by Morphogens
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  Authors: Anna Kicheva; James Briscoe
  Abstract: Intercellular signaling molecules, known as morphogens, act at a long range in developing tissues to provide spatial information and control properties such as cell fate and tissue growth. The production, transport, and removal of morphogens shape their concentration profiles in time and space. Downstream signaling cascades and gene regulatory networks within cells then convert the spatiotemporal morphogen profiles into distinct cellular responses. Current challenges are to understand the diverse molecular and cellular mechanisms underlying morphogen gradient formation, as well as the logic of downstream regulatory circuits involved in morphogen interpretation. This knowledge, combining experimental and theoretical results, is essential to understand emerging properties of morphogen-controlled systems, such as robustness and scaling.
  PubDate: 2023-10-16T00:00:00Z
Tissue Morphogenesis Through Dynamic Cell and Matrix Interactions
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  Authors: Di Wu; Kenneth M. Yamada Shaohe Wang
  Abstract: Multicellular organisms generate tissues of diverse shapes and functions from cells and extracellular matrices. Their adhesion molecules mediate cell-cell and cell-matrix interactions, which not only play crucial roles in maintaining tissue integrity but also serve as key regulators of tissue morphogenesis. Cells constantly probe their environment to make decisions: They integrate chemical and mechanical information from the environment via diffusible ligand- or adhesion-based signaling to decide whether to release specific signaling molecules or enzymes, to divide or differentiate, to move away or stay, or even whether to live or die. These decisions in turn modify their environment, including the chemical nature and mechanical properties of the extracellular matrix. Tissue morphology is the physical manifestation of the remodeling of cells and matrices by their historical biochemical and biophysical landscapes. We review our understanding of matrix and adhesion molecules in tissue morphogenesis, with an emphasis on key physical interactions that drive morphogenesis.
  PubDate: 2023-10-16T00:00:00Z
The Unreasonable Effectiveness of Reaction Diffusion in Vertebrate Skin
Color Patterning
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  Authors: Michel C. Milinkovitch; Ebrahim Jahanbakhsh Szabolcs Zakany
  Abstract: In 1952, Alan Turing published the reaction-diffusion (RD) mathematical framework, laying the foundations of morphogenesis as a self-organized process emerging from physicochemical first principles. Regrettably, this approach has been widely doubted in the field of developmental biology. First, we summarize Turing's line of thoughts to alleviate the misconception that RD is an artificial mathematical construct. Second, we discuss why phenomenological RD models are particularly effective for understanding skin color patterning at the meso/macroscopic scales, without the need to parameterize the profusion of variables at lower scales. More specifically, we discuss how RD models (a) recapitulate the diversity of actual skin patterns, (b) capture the underlying dynamics of cellular interactions, (c) interact with tissue size and shape, (d) can lead to ordered sequential patterning, (e) generate cellular automaton dynamics in lizards and snakes, (f) predict actual patterns beyond their statistical features, and (g) are robust to model variations. Third, we discuss the utility of linear stability analysis and perform numerical simulations to demonstrate how deterministic RD emerges from the underlying chaotic microscopic agents.
  PubDate: 2023-10-16T00:00:00Z
A Fish Eye View: Retinal Morphogenesis from Optic Cup to Neuronal
Lamination
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  Authors: Caren Norden
  Abstract: The neural retina, at the back of the eye, is a fascinating system to use to discover how cells form tissues in the context of the developing nervous system. The retina is the tissue responsible for perception and transmission of visual information from the environment. It consists of five types of neurons and one type of glia cells that are arranged in a highly organized, layered structure to assure visual information flow. To reach this highly ordered arrangement, intricate morphogenic movements are occurring at the cell and tissue levels. I here discuss recent advances made to understand retinal development, from optic cup formation to neuronal layering. It becomes clear that these complex morphogenetic processes must be studied by taking the cellular as well as the tissue-wide aspects into account. The loop has to be closed between exploring how cell behavior influences tissue development and how the surrounding tissue itself influences single cells. Furthermore, it was recently revealed that the retina is a great system to study neuronal migration phenomena, and more is yet to be discovered in this aspect. Constantly developing imaging and image analysis toolboxes as well as the use of machine learning and synthetic biology make the retina the perfect system to explore more of its exciting neurodevelopmental biology.
  PubDate: 2023-10-16T00:00:00Z
Mechanisms of Regeneration and Fibrosis in the Endometrium
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  Authors: Claire J. Ang; Taylor D. Skokan Kara L. McKinley
  Abstract: The uterine lining (endometrium) regenerates repeatedly over the life span as part of its normal physiology. Substantial portions of the endometrium are shed during childbirth (parturition) and, in some species, menstruation, but the tissue is rapidly rebuilt without scarring, rendering it a powerful model of regeneration in mammals. Nonetheless, following some assaults, including medical procedures and infections, the endometrium fails to regenerate and instead forms scars that may interfere with normal endometrial function and contribute to infertility. Thus, the endometrium provides an exceptional platform to answer a central question of regenerative medicine: Why do some systems regenerate while others scar' Here, we review our current understanding of diverse endometrial disruption events in humans, nonhuman primates, and rodents, and the associated mechanisms of regenerative success and failure. Elucidating the determinants of these disparate repair processes promises insights into fundamental mechanisms of mammalian regeneration with substantial implications for reproductive health.
  PubDate: 2023-10-16T00:00:00Z
tRNA Dysregulation in Neurodevelopmental and Neurodegenerative Diseases
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  Authors: Robert W. Burgess; Erik Storkebaum
  Abstract: Transfer RNAs (tRNAs) decode messenger RNA codons to peptides at the ribosome. The nuclear genome contains many tRNA genes for each amino acid and even each anticodon. Recent evidence indicates that expression of these tRNAs in neurons is regulated, and they are not functionally redundant. When specific tRNA genes are nonfunctional, this results in an imbalance between codon demand and tRNA availability. Furthermore, tRNAs are spliced, processed, and posttranscriptionally modified. Defects in these processes lead to neurological disorders. Finally, mutations in the aminoacyl tRNA synthetases (aaRSs) also lead to disease. Recessive mutations in several aaRSs cause syndromic disorders, while dominant mutations in a subset of aaRSs lead to peripheral neuropathy, again due to an imbalance between tRNA supply and codon demand. While it is clear that disrupting tRNA biology often leads to neurological disease, additional research is needed to understand the sensitivity of neurons to these changes.
  PubDate: 2023-10-16T00:00:00Z
Following the Birth, Life, and Death of mRNAs in Single Cells
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  Authors: Bastian T. Eichenberger; Esther Griesbach, Jessica Mitchell Jeffrey A. Chao
  Abstract: Recent advances in single-molecule imaging of mRNAs in fixed and living cells have enabled the lives of mRNAs to be studied with unprecedented spatial and temporal detail. These approaches have moved beyond simply being able to observe specific events and have begun to allow an understanding of how regulation is coupled between steps in the mRNA life cycle. Additionally, these methodologies are now being applied in multicellular systems and animals to provide more nuanced insights into the physiological regulation of RNA metabolism.
  PubDate: 2023-10-16T00:00:00Z
Transcription Factor Dynamics: One Molecule at a Time
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  Authors: Kaustubh Wagh; Diana A. Stavreva, Arpita Upadhyaya Gordon L. Hager
  Abstract: Cells must tightly regulate their gene expression programs and yet rapidly respond to acute biochemical and biophysical cues within their environment. This information is transmitted to the nucleus through various signaling cascades, culminating in the activation or repression of target genes. Transcription factors (TFs) are key mediators of these signals, binding to specific regulatory elements within chromatin. While live-cell imaging has conclusively proven that TF–chromatin interactions are highly dynamic, how such transient interactions can have long-term impacts on developmental trajectories and disease progression is still largely unclear. In this review, we summarize our current understanding of the dynamic nature of TF functions, starting with a historical overview of early live-cell experiments. We highlight key factors that govern TF dynamics and how TF dynamics, in turn, affect downstream transcriptional bursting. Finally, we conclude with open challenges and emerging technologies that will further our understanding of transcriptional regulation.
  PubDate: 2023-10-16T00:00:00Z
Filopodia In Vitro and In Vivo
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  Authors: Thomas C.A. Blake; Jennifer L. Gallop
  Abstract: Filopodia are dynamic cell surface protrusions used for cell motility, pathogen infection, and tissue development. The molecular mechanisms determining how and where filopodia grow and retract need to integrate mechanical forces and membrane curvature with extracellular signaling and the broader state of the cytoskeleton. The involved actin regulatory machinery nucleates, elongates, and bundles actin filaments separately from the underlying actin cortex. The refined membrane and actin geometry of filopodia, importance of tissue context, high spatiotemporal resolution required, and high degree of redundancy all limit current models. New technologies are improving opportunities for functional insight, with reconstitution of filopodia in vitro from purified components, endogenous genetic modification, inducible perturbation systems, and the study of filopodia in multicellular environments. In this review, we explore recent advances in conceptual models of how filopodia form, the molecules involved in this process, and our latest understanding of filopodia in vitro and in vivo.
  PubDate: 2023-10-16T00:00:00Z
The Tubulin Code, from Molecules to Health and Disease
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  Authors: Elizabeth D. McKenna; Stephanie L. Sarbanes, Steven W. Cummings Antonina Roll-Mecak
  Abstract: Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They support intracellular trafficking, cell division, cellular motility, and other essential cellular processes. In many species, both α-tubulin and β-tubulin are encoded by multiple genes with distinct expression profiles and functionality. Microtubules are further diversified through abundant posttranslational modifications, which are added and removed by a suite of enzymes to form complex, stereotyped cellular arrays. The genetic and chemical diversity of tubulin constitute a tubulin code that regulates intrinsic microtubule properties and is read by cellular effectors, such as molecular motors and microtubule-associated proteins, to provide spatial and temporal specificity to microtubules in cells. In this review, we synthesize the rapidly expanding tubulin code literature and highlight limitations and opportunities for the field. As complex microtubule arrays underlie essential physiological processes, a better understanding of how cells employ the tubulin code has important implications for human disease ranging from cancer to neurological disorders.
  PubDate: 2023-10-16T00:00:00Z
Regulation of TORC2 Function and Localization in Yeast
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  Authors: Anita Emmerstorfer-Augustin; Jeremy Thorner
  Abstract: Every eukaryotic cell contains two distinct multisubunit protein kinase complexes that each contain a TOR (target of rapamycin) protein as the catalytic subunit. These ensembles, designated TORC1 and TORC2, serve as nutrient and stress sensors, signal integrators, and regulators of cell growth and homeostasis, but they differ in their composition, localization, and function. TORC1, activated on the cytosolic surface of the vacuole (or, in mammalian cells, on the cytosolic surface of the lysosome), promotes biosynthesis and suppresses autophagy. TORC2, located primarily at the plasma membrane (PM), maintains the proper levels and bilayer distribution of all PM components (sphingolipids, glycerophospholipids, sterols, and integral membrane proteins), which are needed for the membrane expansion that accompanies cell growth and division and for combating insults to PM integrity. This review summarizes our current understanding of the assembly, structural features, subcellular distribution, and function and regulation of TORC2, obtained largely through studies conducted with Saccharomyces cerevisiae.
  PubDate: 2023-10-16T00:00:00Z
Cis Interactions of Membrane Receptors and Ligands
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  Authors: Enfu Hui
  Abstract: Cell-cell communication is critical for the development and function of multicellular organisms. A crucial means by which cells communicate with one another is physical interactions between receptors on one cell and their ligands on a neighboring cell. Trans ligand:receptor interactions activate the receptor, ultimately leading to changes in the fate of the receptor-expressing cells. Such trans signaling is known to be critical for the functions of cells in the nervous and immune systems, among others. Historically, trans interactions are the primary conceptual framework for understanding cell-cell communication. However, cells often coexpress many receptors and ligands, and a subset of these has been reported to interact in cis and profoundly impact cell functions. Cis interactions likely constitute a fundamental, understudied regulatory mechanism in cell biology. Here, I discuss how cis interactions between membrane receptors and ligands regulate immune cell functions, and I also highlight outstanding questions in the field.
  PubDate: 2023-10-16T00:00:00Z
RBG Motif Bridge-Like Lipid Transport Proteins: Structure, Functions, and
Open Questions
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  Authors: Michael Hanna; Andrés Guillén-Samander Pietro De Camilli
  Abstract: The life of eukaryotic cells requires the transport of lipids between membranes, which are separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the secretory and endocytic pathways and lipid transfer proteins (LTPs) cooperate in this transport. Until recently, known LTPs were shown to carry one or a few lipids at a time and were thought to mediate transport by shuttle-like mechanisms. Over the last few years, a new family of LTPs has been discovered that is defined by a repeating β-groove (RBG) rod-like structure with a hydrophobic channel running along their entire length. This structure and the localization of these proteins at membrane contact sites suggest a bridge-like mechanism of lipid transport. Mutations in some of these proteins result in neurodegenerative and developmental disorders. Here we review the known properties and well-established or putative physiological roles of these proteins, and we highlight the many questions that remain open about their functions.
  PubDate: 2023-10-16T00:00:00Z

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