Subjects -> BIOLOGY (Total: 3492 journals)
    - BIOCHEMISTRY (267 journals)
    - BIOENGINEERING (143 journals)
    - BIOLOGY (1675 journals)
    - BIOPHYSICS (50 journals)
    - BIOTECHNOLOGY (271 journals)
    - BOTANY (254 journals)
    - CYTOLOGY AND HISTOLOGY (32 journals)
    - ENTOMOLOGY (76 journals)
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    - MICROSCOPY (12 journals)
    - ORNITHOLOGY (29 journals)
    - PHYSIOLOGY (73 journals)
    - ZOOLOGY (147 journals)

BIOLOGY (1675 journals)            First | 1 2 3 4 5 6 7 8 | Last

Showing 801 - 1000 of 1720 Journals sorted alphabetically
International Journal of Peptide Research and Therapeutics     Partially Free   (Followers: 6)
International Journal of Peptides     Open Access   (Followers: 2)
International Journal of Pharmaceutical and Life Sciences     Open Access   (Followers: 5)
International Journal of Phytopathology     Open Access   (Followers: 5)
International Journal of Phytoremediation     Hybrid Journal   (Followers: 1)
International Journal of Plant Genomics     Open Access   (Followers: 4)
International Journal of Plant Research     Open Access   (Followers: 3)
International Journal of Primatology     Hybrid Journal   (Followers: 7)
International Journal of Reproductive BioMedicine     Open Access   (Followers: 1)
International Journal of Scientific Reports     Open Access   (Followers: 4)
International Journal of Secondary Metabolite     Open Access   (Followers: 2)
International Journal of Signs and Semiotic Systems     Full-text available via subscription  
International Journal of Speleology     Open Access   (Followers: 3)
International Journal of Systems Biology and Biomedical Technologies     Full-text available via subscription   (Followers: 3)
International Journal of Tropical Insect Science     Hybrid Journal   (Followers: 1)
International Journal of Tryptophan Research     Open Access  
International Letters of Natural Sciences     Open Access   (Followers: 2)
International Multidisciplinary Research Journal     Open Access  
International Review of Cell and Molecular Biology     Full-text available via subscription   (Followers: 7)
International Review of Hydrobiology     Hybrid Journal   (Followers: 2)
Intervirology     Full-text available via subscription  
IntraVital     Full-text available via subscription  
Invertebrate Biology     Hybrid Journal   (Followers: 10)
Invertebrate Neuroscience     Hybrid Journal   (Followers: 4)
Invertebrate Systematics     Hybrid Journal   (Followers: 8)
Investiga : TEC     Open Access  
Investigación Joven     Open Access  
Iranian Journal of Parasitology     Open Access   (Followers: 2)
IRBM     Full-text available via subscription  
IRBM News     Full-text available via subscription  
iScience     Open Access  
Islets     Full-text available via subscription   (Followers: 1)
Israel Journal of Ecology and Evolution     Full-text available via subscription   (Followers: 1)
Istituto Lombardo - Accademia di Scienze e Lettere - Incontri di Studio     Open Access  
Italian Journal of Mycology     Open Access  
ITBM-RBM     Full-text available via subscription   (Followers: 1)
ITBM-RBM News     Full-text available via subscription   (Followers: 1)
IUBMB Life     Hybrid Journal   (Followers: 6)
IUFS Journal of Biology     Open Access  
Izvestiya, Atmospheric and Oceanic Physics     Full-text available via subscription   (Followers: 1)
Izvestiya, Physics of the Solid Earth     Hybrid Journal   (Followers: 2)
Jahangirnagar University Journal of Biological Sciences     Open Access   (Followers: 1)
Japanese Journal of Applied Physics     Full-text available via subscription   (Followers: 6)
JCI Insight     Open Access   (Followers: 3)
JDREAM : Journal of interDisciplinary REsearch Applied to Medicine     Open Access  
JETP Letters     Hybrid Journal   (Followers: 3)
JKI Datenblätter : Pflanzenkrankheiten und Diagnose     Open Access   (Followers: 2)
Jornal Interdisciplinar de Biociências     Open Access  
Journal Biastatistics : Biomedics, Industry & Business And Social Statistics     Open Access  
Journal of Bacteriology & Parasitology     Open Access   (Followers: 5)
Journal of Bioanalysis & Biomedicine     Open Access   (Followers: 1)
Journal of Bioequivalence & Bioavailability     Open Access  
Journal of Bioremediation & Biodegradation     Open Access   (Followers: 4)
Journal of Computer Science & Systems Biology     Open Access   (Followers: 5)
Journal of Proteomics & Bioinformatics     Open Access   (Followers: 10)
Journal of Advanced Laboratory Research in Biology     Open Access   (Followers: 1)
Journal of Advances in Biology     Open Access   (Followers: 5)
Journal of Advances in Biology & Biotechnology     Open Access   (Followers: 1)
Journal of Agricultural, Biological & Environmental Statistics     Hybrid Journal   (Followers: 11)
Journal of Al-Qadisiyah for Pure Science     Open Access   (Followers: 1)
Journal of Amino Acids     Open Access   (Followers: 4)
Journal of Anatomy     Hybrid Journal   (Followers: 7)
Journal of AOAC International     Full-text available via subscription   (Followers: 8)
Journal of Applied Biobehavioral Research     Hybrid Journal  
Journal of Applied Bioinformatics & Computational Biology     Hybrid Journal   (Followers: 5)
Journal of Applied Biological Sciences     Open Access   (Followers: 2)
Journal of Applied Biosciences     Open Access   (Followers: 2)
Journal of Applied Ichthyology     Hybrid Journal   (Followers: 6)
Journal of Applied Life Sciences International     Open Access   (Followers: 1)
Journal of Applied Phycology     Hybrid Journal   (Followers: 10)
Journal of Applied Virology     Open Access   (Followers: 5)
Journal of Aquatic Sciences     Full-text available via subscription   (Followers: 3)
Journal of Arachnology     Full-text available via subscription  
Journal of Asia-Pacific Biodiversity     Open Access  
Journal of Astrobiology & Outreach     Open Access   (Followers: 3)
Journal of Avian Biology     Hybrid Journal   (Followers: 24)
Journal of Basic Microbiology     Hybrid Journal   (Followers: 3)
Journal of Bio-Science     Open Access   (Followers: 3)
Journal of Bio-X Research     Open Access   (Followers: 1)
Journal of Biobased Materials and Bioenergy     Full-text available via subscription  
Journal of Biocommunication     Open Access   (Followers: 2)
Journal of Biodiversity Management & Forestry     Hybrid Journal   (Followers: 6)
Journal of Bioenergetics and Biomembranes     Hybrid Journal   (Followers: 1)
Journal of Biogeography     Hybrid Journal   (Followers: 45)
Journal of Bioinformatics and Computational Biology     Hybrid Journal   (Followers: 19)
Journal of Bioinformatics and Intelligent Control     Full-text available via subscription   (Followers: 2)
Journal of Bioinformatics and Sequence Analysis     Open Access   (Followers: 1)
Journal of Biological Control     Hybrid Journal   (Followers: 2)
Journal of Biological Dynamics     Open Access   (Followers: 1)
Journal of Biological Education     Hybrid Journal   (Followers: 2)
Journal of Biological Engineering     Open Access   (Followers: 3)
Journal of Biological Methods     Open Access  
Journal of Biological Physics     Hybrid Journal   (Followers: 1)
Journal of Biological Research - Thessaloniki     Open Access  
Journal of Biological Sciences     Open Access   (Followers: 5)
Journal of Biological Systems     Hybrid Journal   (Followers: 2)
Journal of Biology and Life Science     Open Access   (Followers: 2)
Journal of Biology, Agriculture and Healthcare     Open Access   (Followers: 11)
Journal of Biomechanics     Hybrid Journal   (Followers: 42)
Journal of Biomedical Education     Open Access   (Followers: 2)
Journal of Biomedical Informatics     Partially Free   (Followers: 16)
Journal of Biomedical Informatics : X     Open Access  
Journal of Biomedical Materials Research Part A     Hybrid Journal   (Followers: 3)
Journal of Biomedical Materials Research Part B : Applied Biomaterials     Hybrid Journal   (Followers: 2)
Journal of Biomedical Nanotechnology     Full-text available via subscription   (Followers: 3)
Journal of Biomedical Physics and Engineering     Open Access  
Journal of Biomedical Science and Engineering     Open Access   (Followers: 2)
Journal of Bionic Engineering     Hybrid Journal  
Journal of Bioresource Management     Open Access  
Journal of Biorheology     Hybrid Journal  
Journal of Biosafety and Biosecurity     Open Access  
Journal of Bioscience and Bioengineering     Full-text available via subscription   (Followers: 31)
Journal of Biosciences and Medicines     Open Access   (Followers: 3)
Journal of Biosocial Science     Hybrid Journal   (Followers: 5)
Journal of Bryology     Hybrid Journal   (Followers: 7)
Journal of Cell Biology     Full-text available via subscription   (Followers: 49)
Journal of Cell Communication and Signaling     Hybrid Journal  
Journal of Cell Death     Open Access   (Followers: 2)
Journal of Cell Science     Full-text available via subscription   (Followers: 18)
Journal of Cellular Biochemistry     Hybrid Journal   (Followers: 4)
Journal of Cellular Physiology     Hybrid Journal   (Followers: 7)
Journal of Cerebral Blood Flow & Metabolism     Hybrid Journal   (Followers: 2)
Journal of Chromatography B     Hybrid Journal   (Followers: 35)
Journal of Clinical Bioinformatics     Open Access   (Followers: 5)
Journal of Clinical Toxicology     Open Access   (Followers: 6)
Journal of Communications Technology and Electronics     Hybrid Journal   (Followers: 2)
Journal of Contemporary Physics (Armenian Academy of Sciences)     Hybrid Journal   (Followers: 10)
Journal of Crustacean Biology     Hybrid Journal   (Followers: 3)
Journal of Developmental Biology     Open Access   (Followers: 2)
Journal of Ecology and The Natural Environment     Open Access   (Followers: 4)
Journal of Education, Health and Sport     Open Access   (Followers: 4)
Journal of Electrical Bioimpedance     Open Access   (Followers: 2)
Journal of Electromyography and Kinesiology     Hybrid Journal   (Followers: 5)
Journal of Environment and Ecology     Open Access   (Followers: 10)
Journal of Environment and Sociobiology     Hybrid Journal   (Followers: 1)
Journal of Environmental Analysis and Progress     Open Access  
Journal of Environmental Radioactivity     Hybrid Journal   (Followers: 3)
Journal of Environmental Science and Natural Resources     Open Access   (Followers: 4)
Journal of Ethnobiology     Full-text available via subscription   (Followers: 4)
Journal of Ethnobiology and Ethnomedicine     Open Access  
Journal of Ethology     Hybrid Journal   (Followers: 3)
Journal of Evolutionary Biology     Hybrid Journal   (Followers: 26)
Journal of Evolutionary Biology Research     Open Access  
Journal of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
Journal of Experimental Life Science     Open Access  
Journal of Experimental Marine Biology and Ecology     Hybrid Journal   (Followers: 41)
Journal of Fish Biology     Hybrid Journal   (Followers: 36)
Journal of Functional Biomaterials     Open Access   (Followers: 3)
Journal of Fungi     Open Access   (Followers: 3)
Journal of Genomics     Open Access   (Followers: 1)
Journal of Great Lakes Research     Hybrid Journal   (Followers: 7)
Journal of Green Science and Technology     Full-text available via subscription   (Followers: 2)
Journal of Health and Biological Sciences     Open Access   (Followers: 1)
Journal of Heredity     Hybrid Journal   (Followers: 4)
Journal of Huazhong University of Science and Technology [Medical Sciences]     Hybrid Journal  
Journal of Human Evolution     Hybrid Journal   (Followers: 18)
Journal of Hymenoptera Research     Open Access   (Followers: 3)
Journal of Ichthyology     Full-text available via subscription   (Followers: 3)
Journal of Insect Behavior     Hybrid Journal   (Followers: 7)
Journal of Insect Biodiversity     Open Access   (Followers: 4)
Journal of Insect Conservation     Hybrid Journal   (Followers: 11)
Journal of Institute of Science and Technology     Open Access  
Journal of Integrated OMICS     Open Access  
Journal of Integrated Pest Management     Open Access   (Followers: 3)
Journal of Integrative Environmental Sciences     Hybrid Journal   (Followers: 4)
Journal of Intelligent Transportation Systems: Technology, Planning, and Operations     Hybrid Journal   (Followers: 4)
Journal of Invertebrate Pathology     Hybrid Journal   (Followers: 3)
Journal of Kerbala University     Open Access   (Followers: 1)
Journal of Landscape Ecology     Open Access   (Followers: 20)
Journal of Law and the Biosciences     Open Access   (Followers: 5)
Journal of Leukocyte Biology     Open Access   (Followers: 2)
Journal of Life and Earth Science     Open Access  
Journal of Life Sciences Research     Open Access  
Journal of Lipid Research     Full-text available via subscription   (Followers: 6)
Journal of Lipids     Open Access  
Journal of Luminescence     Hybrid Journal   (Followers: 5)
Journal of Mammalian Evolution     Hybrid Journal   (Followers: 7)
Journal of Mammalian Ova Research     Full-text available via subscription  
Journal of Mammalogy     Full-text available via subscription   (Followers: 16)
Journal of Mammary Gland Biology and Neoplasia     Hybrid Journal   (Followers: 1)
Journal of Marine and Aquatic Sciences     Open Access   (Followers: 1)
Journal of Marine Sciences     Open Access   (Followers: 17)
Journal of Mathematical Biology     Hybrid Journal   (Followers: 8)
Journal of Mechanics in Medicine and Biology     Hybrid Journal  
Journal of Medical Primatology     Hybrid Journal   (Followers: 1)
Journal of Medical Toxicology     Hybrid Journal   (Followers: 6)
Journal of Medicinal Botany     Open Access  
Journal of Medicine and Philosophy     Hybrid Journal   (Followers: 8)
Journal of Melittology     Open Access   (Followers: 1)
Journal of Membrane Biology     Hybrid Journal   (Followers: 1)
Journal of Membrane Computing     Hybrid Journal  
Journal of Membrane Science     Hybrid Journal   (Followers: 25)
Journal of Metabolomics & Systems Biology     Open Access   (Followers: 2)
Journal of Molecular Biology     Hybrid Journal   (Followers: 45)
Journal of Molecular Biology Research     Open Access   (Followers: 3)
Journal of Molecular Catalysis B: Enzymatic     Hybrid Journal   (Followers: 1)
Journal of Molecular Cell Biology     Hybrid Journal   (Followers: 14)
Journal of Molecular Evolution     Hybrid Journal   (Followers: 6)
Journal of Molecular Signaling     Open Access  
Journal of Molecular Structure     Hybrid Journal   (Followers: 7)

  First | 1 2 3 4 5 6 7 8 | Last

Similar Journals
Journal Cover
Journal of Genomics
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 1839-9940
Published by Ivyspring International Publisher Homepage  [8 journals]
  • Genetic variation in N- and C-terminal regions of bovine DNAJA1 heat shock
           protein gene in African, Asian and American cattle

    • Authors: Oyeyemi O. Ajayi; Sunday O. Peters, Marcos De Donato, F. Denis Mujibi, Waqas A. Khan, Tanveer Hussain, Masroor E. Babar, Ikhide G. Imumorin, Bolaji N. Thomas
      Pages: 1 - 8
      Abstract: DNAJA1 or heat shock protein 40 (Hsp40) is associated with heat adaptation in various organisms. We amplified and sequenced a total of 1,142 bp of bovine Hsp40 gene representing the critical N-terminal (NTR) and C-terminal (CTR) regions in representative samples of African, Asian and American cattle breeds. Eleven and 9 different haplotypes were observed in the NTR in Asian and African breeds respectively while in American Brangus, only two mutations were observed resulting in two haplotypes. The CTR appears to be highly conserved between cattle and yak. In-silico functional analysis with PANTHER predicted putative deleterious functional impact of c.161 T>A; p. V54Q while alignment of bovine and human NTR-J domains revealed that p.Q19H, p.E20Q and p. E21X mutations occurred in helix 2 and p.V54Q missense mutation occurred in helix 3 respectively. The 124 bp insertion found in the yak DNAJA1 ortholog may have significant functional relevance warranting further investigation. Our results suggest that these genetic differences may be concomitant with population genetic history and possible functional consequences for climate adaptation in bovidae.
      Citation: Journal of Genomics
      PubDate: 2018
      Issue No: Vol. 6, No. 1 (2018)
       
  • Constructing a 'Chromonome' of Yellowtail (Seriola quinqueradiata) for
           Comparative Analysis of Chromosomal Rearrangements

    • Authors: Junya Kawase; Jun-ya Aoki, Kazuo Araki
      Pages: 9 - 19
      Abstract: To investigate chromosome evolution in fish species, we newly mapped 181 markers that allowed us to construct a yellowtail (Seriola quinqueradiata) radiation hybrid (RH) physical map with 1,713 DNA markers, which was far denser than a previous map, and we anchored the de novo assembled sequences onto the RH physical map. Finally, we mapped a total of 13,977 expressed sequence tags (ESTs) on a genome sequence assembly aligned with the physical map. Using the high-density physical map and anchored genome sequences, we accurately compared the yellowtail genome structure with the genome structures of five model fishes to identify characteristics of the yellowtail genome. Between yellowtail and Japanese medaka (Oryzias latipes), almost all regions of the chromosomes were conserved and some blocks comprising several markers were translocated. Using the genome information of the spotted gar (Lepisosteus oculatus) as a reference, we further documented syntenic relationships and chromosomal rearrangements that occurred during evolution in four other acanthopterygian species (Japanese medaka, zebrafish, spotted green pufferfish and three-spined stickleback). The evolutionary chromosome translocation frequency was 1.5-2-times higher in yellowtail than in medaka, pufferfish, and stickleback.
      Citation: Journal of Genomics
      PubDate: 2018
      Issue No: Vol. 6, No. 1 (2018)
       
  • High Quality Draft Genomes of the Type Strains Geobacillus
           thermocatenulatus DSM 730T, G. uzenensis DSM 23175T And Parageobacillus
           galactosidasius DSM 18751T

    • Authors: Winnie Thabisa Ramaloko; Nadine Koen, Shamara Polliack, Habibu Aliyu, Pedro Humberto Lebre, Teresa Mohr, Florian Oswald, Michaela Zwick, Daniel Ray Zeigler, Anke Neumann, Christoph Syldatk, Don Arthur Cowan, Pieter De Maayer
      Pages: 20 - 23
      Abstract: The thermophilic 'Geobacilli' are important sources of thermostable enzymes and other biotechnologically relevant macromolecules. The present work reports the high quality draft genome sequences of previously unsequenced type strains of Geobacillus uzenensis (DSM 23175T), G. thermocatenulatus (DSM 730T) and Parageobacillus galactosidasius (DSM 18751T). Phylogenomic analyses revealed that DSM 18751T and DSM 23175T represent later heterotypic synonyms of P. toebii and G. subterraneus, respectively, while DSM 730T represents the type strain for the species G. thermocatenulatus. These genome sequences will contribute towards a deeper understanding of the ecological and biological diversity and the biotechnological exploitation of the 'geobacilli'.
      Citation: Journal of Genomics
      PubDate: 2018
      Issue No: Vol. 6, No. 1 (2018)
       
  • Genomic Analysis of Propane Metabolism in Methyl Tert-Butyl
           Ether-Degrading Mycobacterium Sp. Strain ENV421

    • Authors: Peter Robert Tupa; Hisako Masuda
      Pages: 24 - 29
      Abstract: Methyl tert-butyl ether (MTBE) is a ground water contaminant with plausible carcinogenic properties. Mycobacterium sp. strain ENV421 cometabolically degrades MTBE and other ethers during the growth on propane as a carbon source. In this study, the 6.2 Mb genome of strain ENV421 was deciphered. The genome sequence revealed the presence of numerous putative propane catabolic genes including genes encoding hydrocarbon oxygenases and short chain alcohol dehydrogenases. These data provide the basis for the elucidation of propane metabolic pathways in strain ENV421 and its application for the remediation of ground water contaminated with toxic ethers.
      Citation: Journal of Genomics
      PubDate: 2018
      Issue No: Vol. 6, No. 1 (2018)
       
  • Complete Genome Sequence of Microcystis aeruginosa NIES-2481 and Common
           Genomic Features of Group G M. aeruginosa

    • Authors: Haruyo Yamaguchi; Shigekatsu Suzuki, Yasunori Osana, Masanobu Kawachi
      Pages: 30 - 33
      Abstract: Microcystis aeruginosa is a freshwater bloom-forming cyanobacterium that is distributed worldwide. M. aeruginosa can be divided into at least 8 phylogenetic groups (A-G and X) at the intraspecific level. Here, we report the complete genome sequence of M. aeruginosa NIES-2481, which was isolated from Lake Kasumigaura, Japan, and is assigned to group G. The complete genome sequence of M. aeruginosa NIES-2481 comprises a 4.29-Mbp circular chromosome and a 147,539-bp plasmid; the circular chromosome and the plasmid contain 4,332 and 167 protein-coding genes, respectively. Comparative analysis with the complete genome of M. aeruginosa NIES-2549, which belongs to the same group with NIES-2481, showed that the genome size is the smallest level in previously sequenced M. aeruginosa strains, and the genomes do not contain a microcystin biosynthetic gene cluster in common. Synteny analysis revealed only small-scale rearrangements between the two genomes.
      Citation: Journal of Genomics
      PubDate: 2018
      Issue No: Vol. 6, No. 1 (2018)
       
  • In-silico Designing and Testing of Primers for Sanger Genome Sequencing of
           Dengue Virus Types of Asian Origin

    • Authors: Ajay Prakash Joshi; Annette Angel, Bennet Angel, Rajendra Kumar Baharia, Suman Rathore, Neha Sharma, Karuna Yadav, Sharad Thanvi, Indu Thanvi, Vinod Joshi
      Pages: 34 - 40
      Abstract: Rarity in reporting whole genome sequence of Dengue virus from dengue endemic countries leaves lacunae in understanding regional pattern of virus mutation and ultimately leading to non-understanding of transmission pattern and clinical outcomes emerging at regional levels. Due to inter-serotype genomic similarity and intra-serotype genomic diversity, appropriate designing of primer pairs appears as an exhaustive exercise. Present paper reports new Dengue virus type-specific primer which may help in characterizing virus specific to Asian origin. Genomes of dengue virus serotypes of Asian region were searched and using advanced bioinformatics tools, serotype specific primers were designed and tested for their targeted amplification efficiency. 19 primers sets for DENV-1, 18 primer sets for DENV-2, 17 for DENV-3 and 18 for DENV-4 were designed. In-silico and experimental testing of the designed primers were performed on virus isolated from both clinical isolates and passaged cultures. While all 17 and 18 primer sets of DENV-3 and DENV-2 respectively yielded good quality sequencing results; in case of DENV-4, 16 out of 18 primer sets and in DENV-1, 16 out of 19 primer sets yielded good results. Average sequencing read length was 382 bases and around 82% nucleotide bases were Phred quality QV20 bases (representing an accuracy of circa one miscall every 100 bases) or higher. Results also highlighted importance of use of primer development algorithm and identified genomic regions which are conservative, yet specific for developing primers to achieve efficiency and specificity during experiments.
      Citation: Journal of Genomics
      PubDate: 2018
      Issue No: Vol. 6, No. 1 (2018)
       
  • De novo Assembly of the Burying Beetle Nicrophorus orbicollis (Coleoptera:
           Silphidae) Transcriptome Across Developmental Stages with Identification
           of Key Immune Transcripts

    • Authors: Harim I. Won; Thomas T. Schulze, Emalie J. Clement, Gabrielle F. Watson, Sean M. Watson, Rosalie C. Warner, Elizabeth A. M. Ramler, Elias J. Witte, Mark A. Schoenbeck, Claudia M. Rauter, Paul H. Davis
      Pages: 41 - 52
      Abstract: Burying beetles (Nicrophorus spp.) are among the relatively few insects that provide parental care while not belonging to the eusocial insects such as ants or bees. This behavior incurs energy costs as evidenced by immune deficits and shorter life-spans in reproducing beetles. In the absence of an assembled transcriptome, relatively little is known concerning the molecular biology of these beetles. This work details the assembly and analysis of the Nicrophorus orbicollis transcriptome at multiple developmental stages. RNA-Seq reads were obtained by next-generation sequencing and the transcriptome was assembled using the Trinity assembler. Validation of the assembly was performed by functional characterization using Gene Ontology (GO), Eukaryotic Orthologous Groups (KOG), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Differential expression analysis highlights developmental stage-specific expression patterns, and immunity-related transcripts are discussed. The data presented provides a valuable molecular resource to aid further investigation into immunocompetence throughout this organism's sexual development.
      Citation: Journal of Genomics
      PubDate: 2018
      Issue No: Vol. 6, No. 1 (2018)
       
  • Identification of Sex-associated SNPs of Greater Amberjack (Seriola
           dumerili)

    • Authors: Junya Kawase; Jun-ya Aoki, Kazuhisa Hamada, Akiyuki Ozaki, Kazuo Araki
      Pages: 53 - 62
      Abstract: The sex determination systems of fish are highly diverse compared with those of mammals. Thus, performing investigations using nonmodel fish species helps to understand the highly diverse sex determination systems of fish. Because greater amberjack (Seriola dumerili) is one of the most important edible fish globally and knowledge of its sex determination system is economically important in the field of aquaculture, we are interested in the mechanisms of sex determination of Seriola species. In this study, we identified sex-associated SNPs of greater amberjack using SNP information of 10 males and 10 females by an association test. We determined that the sex-associated SNPs were on chromosome 12 and mainly covered with two scaffolds (about 7.1 Mbp). Genotypes of sex-associated SNPs indicated that females are the heterogametic sex (ZZ/ZW). Furthermore, we compared the genomic structure of greater amberjack with those of Japanese amberjack (Seriola quinqueradiata), California yellowtail (Seriola dorsalis), and medaka (Oryzias latipes). Whole-genome alignments and synteny analysis indicated that the sex determination system of greater amberjack is markedly different from that of medaka and implied that the sex determination system is conserved in the Seriola species.
      Citation: Journal of Genomics
      PubDate: 2018
      Issue No: Vol. 6, No. 1 (2018)
       
  • Isolation and Identification of an Anthracimycin Analogue from
           Nocardiopsis kunsanensis, a Halophile from a Saltern, by Genomic Mining
           Strategy

    • Authors: Fernanda L. Sirota; Falicia Goh, Kia-Ngee Low, Lay-Kien Yang, Sharon C. Crasta, Birgit Eisenhaber, Frank Eisenhaber, Yoganathan Kanagasundaram, Siew Bee Ng
      Pages: 63 - 73
      Abstract: Modern medicine is unthinkable without antibiotics; yet, growing issues with microbial drug resistance require intensified search for new active compounds. Natural products generated by Actinobacteria have been a rich source of candidate antibiotics, for example anthracimycin that, so far, is only known to be produced by Streptomyces species. Based on sequence similarity with the respective biosynthetic cluster, we sifted through available microbial genome data with the goal to find alternative anthracimycin-producing organisms. In this work, we report about the prediction and experimental verification of the production of anthracimycin derivatives by Nocardiopsis kunsanensis, a non-Streptomyces actinobacterial microorganism. We discovered N. kunsanensis to predominantly produce a new anthracimycin derivative with methyl group at C-8 and none at C-2, labeled anthracimycin BII-2619, besides a minor amount of anthracimycin. It displays activity against Gram-positive bacteria with similar low level of mammalian cytotoxicity as that of anthracimycin.
      Citation: Journal of Genomics
      PubDate: 2018
      Issue No: Vol. 6, No. 1 (2018)
       
  • Genome Wide Analysis Reveals the Extrinsic Cellulolytic and Biohydrogen
           Generating Abilities of Neocallimastigomycota Fungi

    • Authors: Ayyappa Kumar Sista Kameshwar; Wensheng Qin
      Pages: 74 - 87
      Abstract: Ruminating animals, especially cattle lack the carbohydrate active enzyme encoding genes which are required for the degradation of the glycosidic linkages of plant cell wall carbohydrates (such as cellulose, hemicellulose, lignin and pectin). Thus, ruminating animals are completely dependent on the microorganisms (anaerobic bacteria and fungi, methanogenic archaea and protozoa) residing in their rumen (hindgut). In this study, we have retrieved and analyzed the complete genome wide annotations of the Neocallimastigomycota division fungi such as Anaeromyces robustus, Neocallismatix californiae, Orpinomyces sp, Piromyces finnis, Piromyces sp E2. We have retrieved the InterPro, CAZy, KOG, KEGG, SM Clusters and MEROPS genome level data of these anaerobic fungi from JGI-MycoCosm database. Results obtained in our study reveals that, the genomes of anaerobic fungi completely lack genes encoding for lignin degrading auxiliary activity enzymes. Contrastingly, these fungi outnumbered other fungi by having highest number of CAZyme encoding genes. The genes encoding for dockerins and carbohydrate binding modules exaggerated other CAZymes which are involved in the structure and functioning of cellulosomes. Presence of cellulosomes and higher number of carbohydrate transport and metabolism genes also endorses the plant cell wall carbohydrate degrading abilities of these fungi. We also reported the tentative total cellulolytic, hemicellulolytic and pectinolytic abilities. And we have explicitly reported the genes, enzymes and the mechanisms involved in structure and functioning of the cellulosomes and hydrogenosomes. Our present work reveals the genomic machinery underlying the extrinsic plant cell wall degrading abilities of the anaerobic fungi. Results obtained in our study can be significantly applied in improving the gut health of cattle and especially in the fields of biofuel, biorefining and bioremediation-based industries.
      Citation: Journal of Genomics
      PubDate: 2018
      Issue No: Vol. 6, No. 1 (2018)
       
  • Genetic Diversity of Bovine Major Histocompatibility Complex Class II DRB3
           locus in cattle breeds from Asia compared to those from Africa and America
           

    • Authors: Sunday O. Peters; Tanveer Hussain, Adeyemi S. Adenaike, Matthew A Adeleke, Marcos De Donato, Jordan Hazzard, Masroor E Babar, Ikhide G. Imumorin
      Pages: 88 - 97
      Abstract: Genetic polymorphisms and diversity of BoLA-DRB3.2 are essential because of DRB3 gene's function in innate immunity and its association with infectious diseases resistance or tolerance in cattle. The present study was aimed at assessing the level of genetic diversity of DRB3 in the exon 2 (BoLA-DRB3.2) region in African, American and Asian cattle breeds. Amplification of exon 2 in 174 cattle revealed 15 haplotypes. The breeds with the highest number of haplotypes were Brangus (10), Sokoto Gudali (10) and Dajal (9), while the lowest number of haplotypes were found in Holstein and Sahiwal with 4 haplotypes each. Medium Joining network obtained from haplotypic data showed that all haplotypes condensed around a centric area and each sequence (except in H-3, H-51 and H-106) representing almost a specific haplotype. The BoLA-DRB3.2 sequence analyses revealed a non-significant higher rate of non-synonymous (dN) compared to synonymous substitutions (dS). The ratio of dN/dS substitution across the breeds were observed to be greater than one suggesting that variation at the antigen-binding sites is under positive selection; thus increasing the chances of these breeds to respond to wide array of pathogenic attacks. An analysis of molecular variance revealed that 94.01 and 5.99% of the genetic variation was attributable to differences within and among populations, respectively. Generally, results obtained suggest that within breed genetic variation across breeds is higher than between breeds. This genetic information will be important for investigating the relationship between BoLADRB3.2 and diseases in various cattle breeds studied with attendant implication on designing breeding programs that will aim at selecting individual cattle that carry resistant alleles.
      Citation: Journal of Genomics
      PubDate: 2018
      Issue No: Vol. 6, No. 1 (2018)
       
  • Mitochondrial genomes of the South American frogs Eupsophus vertebralis
           and E. emiliopugini (Neobatrachia: Alsodidae) and their phylogenetic
           relationships

    • Authors: Elkin Y. Suárez-Villota; Camila A. Quercia, José J. Nuñez
      Pages: 98 - 102
      Abstract: We report the sequencing and compare the mitochondrial genomes of the South American ground frogs Eupsophus vertebralis and E. emiliopugini and reconstruct phylogenetic relationships among Eupsophus species. These genomes consist of 16,156 and 16,711 bp in length, respectively and contain 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes (tRNA), and partial non-coding D-loop region. Both genomes share 94.5% identity with 879 variable sites. A phylogenetic analysis with other available mitogenomes recovered both species as the sister clade of Alsodes gargola. Sequences from D-loop, CO1, and Cyt b, amplified and sequenced with primers developed from the mitochondrial genomes, allowed us to reconstruct phylogenetic relationships among Eupsophus species. Since our report represents the first mitogenomes for the genus Eupsophus, we expect these data will be valuable for further studies on conservation genetics and on the evolution of Patagonian amphibians.
      Citation: Journal of Genomics
      PubDate: 2018
      Issue No: Vol. 6, No. 1 (2018)
       
 
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