Subjects -> BIOLOGY (Total: 3174 journals)
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BIOLOGY (1491 journals)                  1 2 3 4 5 6 7 8 | Last

Showing 1 - 200 of 1720 Journals sorted alphabetically
AAPS Journal     Hybrid Journal   (Followers: 24)
Abasyn Journal of Life Sciences     Open Access   (Followers: 2)
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 3)
ACS Synthetic Biology     Hybrid Journal   (Followers: 30)
Acta Biologica Hungarica     Full-text available via subscription   (Followers: 5)
Acta Biologica Marisiensis     Open Access  
Acta Biologica Sibirica     Open Access   (Followers: 1)
Acta Biologica Turcica     Open Access   (Followers: 1)
Acta Biomaterialia     Hybrid Journal   (Followers: 31)
Acta Biotheoretica     Hybrid Journal   (Followers: 3)
Acta Chiropterologica     Full-text available via subscription   (Followers: 5)
acta ethologica     Hybrid Journal   (Followers: 5)
Acta Fytotechnica et Zootechnica     Open Access   (Followers: 2)
Acta Ichthyologica et Piscatoria     Open Access   (Followers: 4)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Musei Silesiae, Scientiae Naturales     Open Access  
Acta Neurobiologiae Experimentalis     Open Access  
Acta Scientiae Biological Research     Open Access   (Followers: 1)
Acta Scientiarum. Biological Sciences     Open Access   (Followers: 2)
Acta Scientifica Naturalis     Open Access   (Followers: 2)
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis     Open Access   (Followers: 2)
Acta Universitatis Lodziensis : Folia Biologica et Oecologica     Open Access  
Actualidades Biológicas     Open Access   (Followers: 1)
Advanced Biology     Hybrid Journal   (Followers: 1)
Advanced Health Care Technologies     Open Access   (Followers: 12)
Advanced Journal of Graduate Research     Open Access   (Followers: 1)
Advanced Membranes     Open Access   (Followers: 4)
Advanced Quantum Technologies     Hybrid Journal   (Followers: 3)
Advances in Bioinformatics     Open Access   (Followers: 21)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4)
Advances in Biology     Open Access   (Followers: 10)
Advances in Biomarker Sciences and Technology     Open Access   (Followers: 2)
Advances in Biosensors and Bioelectronics     Open Access   (Followers: 6)
Advances in Cell Biology/ Medical Journal of Cell Biology     Open Access   (Followers: 22)
Advances in Ecological Research     Full-text available via subscription   (Followers: 42)
Advances in Environmental Sciences - International Journal of the Bioflux Society     Open Access   (Followers: 14)
Advances in Enzyme Research     Open Access   (Followers: 10)
Advances in High Energy Physics     Open Access   (Followers: 23)
Advances in Human Biology     Open Access   (Followers: 6)
Advances in Life Science and Technology     Open Access   (Followers: 10)
Advances in Life Sciences     Open Access   (Followers: 5)
Advances in Marine Biology     Full-text available via subscription   (Followers: 23)
Advances in Tropical Biodiversity and Environmental Sciences     Open Access   (Followers: 4)
Advances in Virus Research     Full-text available via subscription   (Followers: 7)
Adversity and Resilience Science : Journal of Research and Practice     Hybrid Journal   (Followers: 3)
African Journal of Ecology     Hybrid Journal   (Followers: 17)
African Journal of Range & Forage Science     Hybrid Journal   (Followers: 12)
AFRREV STECH : An International Journal of Science and Technology     Open Access   (Followers: 3)
Ageing Research Reviews     Hybrid Journal   (Followers: 13)
Aggregate     Open Access   (Followers: 1)
Aging Cell     Open Access   (Followers: 23)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
AJP Cell Physiology     Hybrid Journal   (Followers: 14)
AJP Endocrinology and Metabolism     Hybrid Journal   (Followers: 25)
AJP Lung Cellular and Molecular Physiology     Hybrid Journal   (Followers: 3)
Al-Kauniyah : Jurnal Biologi     Open Access  
Alasbimn Journal     Open Access   (Followers: 1)
Alces : A Journal Devoted to the Biology and Management of Moose     Open Access  
All Life     Open Access  
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Journal of Agricultural and Biological Sciences     Open Access   (Followers: 6)
American Journal of Bioethics     Hybrid Journal   (Followers: 18)
American Journal of Human Biology     Hybrid Journal   (Followers: 15)
American Journal of Medical and Biological Research     Open Access   (Followers: 3)
American Journal of Plant Sciences     Open Access   (Followers: 19)
American Journal of Primatology     Hybrid Journal   (Followers: 15)
American Naturalist     Full-text available via subscription   (Followers: 78)
Amphibia-Reptilia     Hybrid Journal   (Followers: 4)
Anaerobe     Hybrid Journal   (Followers: 3)
Analytical Methods     Hybrid Journal   (Followers: 8)
Analytical Science Advances     Open Access   (Followers: 1)
Anatomical Science International     Hybrid Journal   (Followers: 3)
Animal Cells and Systems     Hybrid Journal   (Followers: 6)
Animal Microbiome     Open Access   (Followers: 1)
Animal Models and Experimental Medicine     Open Access  
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale     Full-text available via subscription   (Followers: 2)
Annales Henri Poincaré     Hybrid Journal   (Followers: 2)
Annales Universitatis Mariae Curie-Sklodowska, sectio C – Biologia     Open Access   (Followers: 1)
Annals of Applied Biology     Hybrid Journal   (Followers: 6)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 18)
Annals of Human Biology     Hybrid Journal   (Followers: 5)
Annals of Science and Technology     Open Access   (Followers: 2)
Annual Research & Review in Biology     Open Access  
Annual Review of Biomedical Engineering     Full-text available via subscription   (Followers: 18)
Annual Review of Biophysics     Full-text available via subscription   (Followers: 24)
Annual Review of Cancer Biology     Full-text available via subscription   (Followers: 3)
Annual Review of Cell and Developmental Biology     Full-text available via subscription   (Followers: 41)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 13)
Annual Review of Genomics and Human Genetics     Full-text available via subscription   (Followers: 27)
Annual Review of Phytopathology     Full-text available via subscription   (Followers: 11)
Anthropological Review     Open Access   (Followers: 27)
Antibiotics     Open Access   (Followers: 10)
Antioxidants     Open Access   (Followers: 4)
Antioxidants & Redox Signaling     Hybrid Journal   (Followers: 8)
Antonie van Leeuwenhoek     Hybrid Journal   (Followers: 3)
Anzeiger für Schädlingskunde     Hybrid Journal   (Followers: 1)
Apidologie     Hybrid Journal   (Followers: 4)
Apmis     Hybrid Journal   (Followers: 1)
APOPTOSIS     Hybrid Journal   (Followers: 8)
Applied Biology     Open Access   (Followers: 1)
Applied Bionics and Biomechanics     Open Access   (Followers: 4)
Applied Phycology     Open Access  
Applied Vegetation Science     Full-text available via subscription   (Followers: 9)
Aquaculture Environment Interactions     Open Access   (Followers: 6)
Aquaculture International     Hybrid Journal   (Followers: 24)
Aquaculture Reports     Open Access   (Followers: 3)
Aquaculture, Aquarium, Conservation & Legislation - International Journal of the Bioflux Society     Open Access   (Followers: 8)
Aquatic Biology     Open Access   (Followers: 8)
Aquatic Ecology     Hybrid Journal   (Followers: 41)
Aquatic Ecosystem Health & Management     Hybrid Journal   (Followers: 15)
Aquatic Science and Technology     Open Access   (Followers: 2)
Aquatic Toxicology     Hybrid Journal   (Followers: 25)
Arabian Journal of Scientific Research / المجلة العربية للبحث العلمي     Open Access  
Archaea     Open Access   (Followers: 3)
Archiv für Molluskenkunde: International Journal of Malacology     Full-text available via subscription   (Followers: 1)
Archives of Biological Sciences     Open Access  
Archives of Microbiology     Hybrid Journal   (Followers: 9)
Archives of Natural History     Hybrid Journal   (Followers: 7)
Archives of Oral Biology     Hybrid Journal   (Followers: 2)
Archives of Virology     Hybrid Journal   (Followers: 6)
Archivum Immunologiae et Therapiae Experimentalis     Hybrid Journal   (Followers: 2)
Arctic     Open Access   (Followers: 1)
Arid Ecosystems     Hybrid Journal   (Followers: 2)
Arquivos do Museu Dinâmico Interdisciplinar     Open Access  
Arthropod Structure & Development     Hybrid Journal   (Followers: 2)
Arthropod Systematics & Phylogeny     Open Access   (Followers: 3)
Artificial DNA: PNA & XNA     Hybrid Journal   (Followers: 2)
Artificial Intelligence in the Life Sciences     Open Access  
Asian Bioethics Review     Full-text available via subscription   (Followers: 2)
Asian Journal of Biological Sciences     Open Access   (Followers: 2)
Asian Journal of Biology     Open Access  
Asian Journal of Biotechnology and Bioresource Technology     Open Access  
Asian Journal of Cell Biology     Open Access   (Followers: 4)
Asian Journal of Developmental Biology     Open Access   (Followers: 1)
Asian Journal of Medical and Biological Research     Open Access   (Followers: 3)
Asian Journal of Nematology     Open Access   (Followers: 4)
Asian Journal of Poultry Science     Open Access   (Followers: 3)
Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche     Open Access  
Australian Life Scientist     Full-text available via subscription   (Followers: 2)
Australian Mammalogy     Hybrid Journal   (Followers: 8)
Autophagy     Hybrid Journal   (Followers: 7)
Avian Biology Research     Hybrid Journal   (Followers: 4)
Avian Conservation and Ecology     Open Access   (Followers: 16)
Bacterial Empire     Open Access   (Followers: 1)
Bacteriology Journal     Open Access   (Followers: 2)
Bacteriophage     Full-text available via subscription   (Followers: 2)
Bangladesh Journal of Bioethics     Open Access  
Bangladesh Journal of Plant Taxonomy     Open Access  
Bangladesh Journal of Scientific Research     Open Access  
Berita Biologi     Open Access  
Between the Species     Open Access   (Followers: 2)
BIO Web of Conferences     Open Access  
Bio-Grafía. Escritos sobre la Biología y su enseñanza     Open Access  
Bio-Lectura     Open Access  
BIO-SITE : Biologi dan Sains Terapan     Open Access  
Bioactive Compounds in Health and Disease     Open Access  
Biocatalysis and Biotransformation     Hybrid Journal   (Followers: 5)
BioCentury Innovations     Full-text available via subscription   (Followers: 2)
Biochemistry and Cell Biology     Hybrid Journal   (Followers: 17)
Biochimie     Hybrid Journal   (Followers: 4)
BioControl     Hybrid Journal   (Followers: 2)
Biocontrol Science and Technology     Hybrid Journal   (Followers: 5)
Biodemography and Social Biology     Hybrid Journal  
BIODIK : Jurnal Ilmiah Pendidikan Biologi     Open Access  
BioDiscovery     Open Access   (Followers: 2)
Biodiversitas : Journal of Biological Diversity     Open Access   (Followers: 1)
Biodiversity : Research and Conservation     Open Access   (Followers: 28)
Biodiversity Data Journal     Open Access   (Followers: 7)
Biodiversity Informatics     Open Access   (Followers: 2)
Biodiversity Information Science and Standards     Open Access   (Followers: 1)
Bioeduscience     Open Access  
Bioeksperimen : Jurnal Penelitian Biologi     Open Access  
Bioelectrochemistry     Hybrid Journal   (Followers: 1)
Bioelectromagnetics     Hybrid Journal   (Followers: 1)
Bioenergy Research     Hybrid Journal   (Followers: 3)
Bioengineering and Bioscience     Open Access   (Followers: 1)
BioEssays     Hybrid Journal   (Followers: 10)
Bioethica     Open Access   (Followers: 1)
Bioethics     Hybrid Journal   (Followers: 21)
BioéthiqueOnline     Open Access   (Followers: 1)
Biogeographia : The Journal of Integrative Biogeography     Open Access   (Followers: 2)
Biogeosciences (BG)     Open Access   (Followers: 14)
Biogeosciences Discussions (BGD)     Open Access   (Followers: 4)
Bioinformatics     Hybrid Journal   (Followers: 216)
Bioinformatics Advances : Journal of the International Society for Computational Biology     Open Access   (Followers: 1)
Bioinformatics and Biology Insights     Open Access   (Followers: 13)
Biointerphases     Open Access   (Followers: 1)
Biojournal of Science and Technology     Open Access  
BioLink : Jurnal Biologi Lingkungan, Industri, Kesehatan     Open Access  
Biologia     Hybrid Journal   (Followers: 1)
Biologia Futura     Hybrid Journal  
Biologia on-line : Revista de divulgació de la Facultat de Biologia     Open Access  
Biological Bulletin     Partially Free   (Followers: 6)
Biological Control     Hybrid Journal   (Followers: 6)
Biological Invasions     Hybrid Journal   (Followers: 22)
Biological Journal of the Linnean Society     Hybrid Journal   (Followers: 19)
Biological Procedures Online     Open Access  
Biological Psychiatry     Hybrid Journal   (Followers: 52)
Biological Psychology     Hybrid Journal   (Followers: 5)

        1 2 3 4 5 6 7 8 | Last

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Journal Cover
Archives of Biological Sciences
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1821-4339 - ISSN (Online) 1821-4339
Published by U of Belgrade Homepage  [9 journals]
  • Buyuan decoction inhibits autophagy in a rat model of chronic obstructive
           pulmonary disease

    • Authors: Chunyan Huang, Shaofeng Li, Chao Xu, Wenlong Song, Lei Xu, Zhihui Lan, Liangji Liu
      Pages: 5 - 14
      Abstract: Paper description:
      Drugs used in chronic obstructive pulmonary disease (COPD) treatment exhibit side effects. Autophagy participates in COPD regulation. Exposure to cigarette smoke causes COPD initiation and progression and increased expression of autophagy markers.
      The mechanism of Buyuan decoction treatment on autophagy in COPD was investigated in an experimental model in Sprague-Dawley rats in which COPD was induced by lipopolysaccharide injection and cigarette smoke exposure.
      Buyuan decoction suppresses autophagy in COPD by regulating the expression of autophagy-related proteins LC3-II/I, BNIP-1, ATG7 and p62, and inhibiting PI3K pathway activation.
      The findings contribute to a novel therapeutic approach for COPD. Abstract: Efforts have been made to find a better therapeutic approach with fewer side effects in treating chronic obstructive pulmonary disease (COPD). This study investigated the effect of Buyuan decoction (BYD) on autophagy in COPD rats. An experimental model with Sprague-Dawley rats was established by lipopolysaccharide (LPS) injection and cigarette smoke exposure. Rats were randomly allocated into blank control (normal control), experimental model, low-dose BYD (8.0 g/kg/day), medium-dose BYD (16.0 g/kg/day), high-dose BYD (32.0 g/kg/day) and 3-MA (methyladenine) groups (6 rats/group). Cell and tissue morphology were observed using hematoxylin and eosin staining. Autophagic vesicles were examined with a transmission electron microscope. Protein expression of LC3-II/I, BNIP-1, ATG7, p62, PI3K and p-PI3K in lung tissue was detected by Western blotting. Compared with the experimental model group, the inflammatory infiltrate in lung tissue was reduced, the nuclei of the pulmonary epithelial cells were restored to normal, and the expression of LC3, BNIP1, ATG7 and p-PI3K was significantly downregulated, while p62 expression was significantly upregulated after treatment with the BYD. The effect was most significant in the low-dose BYD group (P<0.05, all groups). These findings suggest that the BYD inhibits the occurrence of autophagy in the pathogenesis of COPD and that it can be a potential treatment.
      PubDate: 2022-04-01
      DOI: 10.2298/ABS211104047H
      Issue No: Vol. 74, No. 1 (2022)
       
  • Interleukin-17 modulates uPA and MMP2 expression in human periodontal
           ligament mesenchymal stem cells: involvement of the ERK1/2 MAPK pathway

    • Authors: Ivana Okić Đorđević, Tamara Kukolj, Hristina Obradović, Drenka Trivanović, Andjelija Petrović, Slavko Mojsilović, Maja Miletić, Diana Bugarski, Aleksandra Jauković
      Pages: 15 - 24
      Abstract: Paper description:
      Proinflammatory cytokine IL-17 regulates the expression of extracellular proteolytic enzymes in multiple cell types. We investigated whether it contributes to periodontal ligament remodeling and tissue destruction.
      The influence of IL-17 on urokinase-type plasminogen activator (uPA) and metalloproteinase (MMP) MMP2/MMP9 gene and protein expression in periodontal ligament mesenchymal stem cells (PDLMSCs) was investigated by RT-PCR, Western and zymography analyses.
      IL-17 stimulates uPA and matrix MMP-2 gene and protein expression through activation of the extracellular signal-regulated kinase (ERK)1/2 mitogen-activated protein (MAP) kinase signaling pathway.
      IL-17 contributes to extracellular degradation in the periodontal ligament and it could be involved in periodontal disease pathogenesis. Abstract: Periodontal disease is a chronic infection of periodontal tissue characterized by extracellular matrix (ECM) degradation due to increased expression of plasminogen activators and matrix metalloproteinases (MMPs) and various proinflammatory cytokines, including interleukin (IL)-17. Successful regeneration of damaged periodontal tissues depends on the proper functionality of periodontal ligament mesenchymal stem cells (PDLMSCs), especially the production of extracellular matrix proteases. We investigated the influence of IL-17 on ECM remodeling through modulation of urokinase-type plasminogen activator (uPA) and MMP2/MMP9 expression in human PDLMSCs at mRNA, protein and activity levels using by RT-PCR, Western blotting and zymography, respectively. Investigation of the involvement of MAPKs in these processes in PDLMSCs was determined by Western blotting, as well as by utilizing specific p38 and MEK1/2 inhibitors. Our results show that IL-17 activates MAPK signaling in PDLMSCs. Moreover, IL-17 had no effect on MMP9 expression, but it stimulated uPA and MMP2 gene and protein expression in PDLMSCs through the activation of the ERK1/2 MAPK signaling pathway. The obtained data suggest that IL-17 contributes to ECM degradation in the periodontal ligament by stimulating uPA and MMP2 expression and activity in PDLMSCs. This information is important for understanding periodontal disease development and defining future directions of its treatment.
      PubDate: 2022-04-01
      DOI: 10.2298/ABS210929048O
      Issue No: Vol. 74, No. 1 (2022)
       
  • Integration of miRNA-lncRNA-mRNA profiles in liver tissue from EpCAM
           knockout mice

    • Authors: Zili Lei, Yuting Lei, Guibin Chen, Shaomin Liu, Wanwan Liu, Li Huang, Lanxiang Yang, Huijuan Wu, Yanhong Yang
      Pages: 25 - 39
      Abstract: Paper description:
      Epithelial cell adhesion molecule (EpCAM) is highly expressed in the liver during development and disease, however, its role in development and liver pathology is unclear.
      Liver tissues of EpCAM-/- and WT mice at P0 stage were collected for RNA sequencing. Hepatic expression of miRNAs, lncRNAs and mRNAs was confirmed by qPCR.
      Comprehensive miRNA, lncRNA and mRNA expression profiles in EpCAM-/- mice were established, indicating that EpCAM plays important roles in liver glucose and lipid metabolism.
      These results will help to elucidate functions and mechanisms of EpCAM in liver development and diseases. Abstract: The epithelial cell adhesion molecule (EpCAM) is highly expressed in the liver during development and diseases. However, its role in the development and pathology of liver remains to be explored. The liver tissues of EpCAM-/- and wildtype (WT) mice at P0 stage were used for RNA sequencing. The differently expressed miRNAs, lncRNAs and mRNAs were selected and confirmed by qPCR. The expression of metabolism-related gene SET domain bifurcated 2 (Setdb2) was significantly increased in the liver of EpCAM-/- mice; the triglyceride (TG) and total cholesterol (TC) levels in the liver were also markedly decreased in EpCAM-/- mice. The microRNA (miRNA)-long noncoding RNA (lncRNA)-mRNA regulatory networks indicated that EpCAM may play important roles in glucose and lipid metabolism of the liver during development and in disease. The comprehensive miRNA, lncRNA and mRNA expression profiles in the developing liver of EpCAM-/- mice established here might help to elucidate functions and mechanisms of EpCAM during development and in diseases of the liver.
      PubDate: 2022-04-01
      DOI: 10.2298/ABS211207001L
      Issue No: Vol. 74, No. 1 (2022)
       
  • Association of rs780094 and rs1260326 glucokinase regulatory protein gene
           polymorphisms with dyslipidemia in a group of Serbian acute ischemic
           stroke patients

    • Authors: Jelena Bašić, Vuk Milošević, Milica Živanović, Jasen Kundalić, Milena Despotović, Tatjana Jevtović-Stoimenov, Ivana Stojanović
      Pages: 41 - 47
      Abstract: Paper description:
      Single nucleotide polymorphisms (SNPs) rs780094 and rs1260326 of the glucokinase regulatory protein gene (GCKR) could be associated with dyslipidemia, a leading risk factor for acute ischemic stroke (AIS) development.
      The influence of GCKR rs780094 and rs1260326 SNPs on the lipid profile and the association of these SNPs with the risk of AIS were assessed.
      The rs780094TT genotype and the rs1260326TT genotype were associated with decreased risk for AIS.
      This study provides a foundation for a better understanding of the biological basis of the influence of GCKR rs780094 and rs1260326 SNPs on AIS development. Abstract: Although genetic variations rs780094 and rs1260326 of the glucokinase regulatory protein gene (GCKR) could be associated with lipid profile imbalance, their influence on acute ischemic stroke (AIS) risk has not yet been established. The aim of this study was to investigate the influence of GCKR single nucleotide polymorphisms (SNPs) rs780094 and rs1260326 on lipid profile parameters in patients with AIS, and to evaluate the association of these SNPs with the risk of AIS. In a case-control study, a total of 148 subjects were screened for GCKR rs780094 and rs1260326 SNPs using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The lipid profile was determined based on serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triacylglycerol (TG) concentrations. The frequencies of the minor rs780094T allele and the minor rs1260326T allele were significantly lower in AIS patients compared to controls. The rs780094TT genotype and the rs1260326TT genotype were associated with decreased risk of AIS compared to wildtype carriers. In conclusion, this is the first study implying that decreased risk of AIS in rs780094 and rs1260326 homozygous minor allele carriers is not caused by dyslipidemia, but possibly by the lack of coagulation factor glycosylation.
      PubDate: 2022-04-01
      DOI: 10.2298/ABS211126002B
      Issue No: Vol. 74, No. 1 (2022)
       
  • Impact of the COVID-19 pandemic on patients receiving intravitreal
           injections

    • Authors: Ningzhi Zhang, Xuejun He, Yiqiao Xing, Ning Yang
      Pages: 49 - 55
      Abstract: Paper description:
      Splitting one vial of anti-vascular endothelial growth factor (VEGF) is no longer carried out after COVID-19, exerting increased financial pressure on patients receiving anti-VEGF intravitreal injections (IVIs).
      The cost and incidence of post-injection endophthalmitis (PIE) before and after the pandemic were analyzed in a retrospective study.
      A single vial used for only one patient dramatically increased the financial burden on IVI patients but did not reduce PIE incidence.
      After the COVID-19 pandemic has been contained, splitting vials into syringes for IVI patients could resume. Abstract: We analyzed the economic benefits versus safety risks of sharing anti-vascular endothelial growth factor (VEGF) vials during the coronavirus disease (COVID-19) pandemic. This single-center retrospective study analyzed the data of patients with neovascular age-related macular degeneration (nAMD), proliferative diabetic retinopathy (PDR) and retinal vein occlusion (RVO) who received anti-VEGF between January 2016 and July 2021 at Renmin Hospital, Wuhan University, China. Costs were compared of the two protocols of intravitreal injections (IVIs) of ranibizumab, aflibercept and conbercept after (i) splitting the vial content for use in two patients and after (ii) disposal of the remaining vial content after use in a single patient, with the COVID-19 outbreak considered as the demarcation point. The incidence rates of post-injection endophthalmitis (PIE) pre- and post-outbreak were analyzed. The mean cost of a single IVI increased by 33.3%, from 3917.67±71.69 to 5222.67±84.98 Chinese Yuan during the pandemic. The incidences of IVI-related culture-positive PIE were 0.0134% (3 in 22448) and 0.0223% (1 in 4479), respectively, before and after the pandemic (P=0.6532). We conclude that vial sharing of IVIs in a large clinical institution is not associated with increased PIE risk and can significantly reduce the cost of therapy.
      PubDate: 2022-04-01
      DOI: 10.2298/ABS220116003Z
      Issue No: Vol. 74, No. 1 (2022)
       
  • RASSF1A and p16 promoter methylation and treatment response in chronic
           hepatitis C genotype 1b patients treated with pegylated
           interferon/ribavirin

    • Authors: Nikola S. Kokanov, Milena M. Krajnović, Snežana P. Jovanović-Ćupić, Bojana R. Kožik, Nina M. Petrović, Ana M. Božović, Vesna Lj. Mandušić
      Pages: 57 - 66
      Abstract: Paper description:
      Patients with chronic hepatitis C genotype 1b would benefit from early detection of molecular markers predicting the response to therapy with pegylated interferon/ribavirin.
      We investigated whether the methylation status of RASSF1A and p16 genes combined with host factors affects the response to therapy and disease progression.
      Simultaneous presence of RASSF1A methylation and the IL28B CC genotype was significantly related to a sustained virologic response and methylation of the RASSF1A
      The methylation status of RASSF1A and IL28B rs12979860 polymorphism could potentially help predict the response to therapy. Abstract: Prevention of chronic hepatitis C (CHC) and its complications is based on antiviral therapy and early detection of reliable molecular markers in persons under risk. We investigated whether the methylation status of RASSF1A and p16 genes, alone or in combination with host and viral factors, affects the response to therapy with pegylated interferon/ribavirin (PEG-IFN/RBV). Methylation-specific polymerase chain reaction (MSP) was used to determine the methylation status of the target promoter sequences of RASSF1A and p16 in circulating-free DNA from the peripheral blood of 49 patients with CHC genotype 1b. The methylation status of the examined genes did not affect the response to therapy. However, the simultaneous presence of either RASSF1A or p16 methylation and the CC genotype of IL28B was significantly related to a sustained virologic response (P=0.009 and P=0.032, respectively). After Bonferroni correction, only the result concerning the RASSF1A gene remained significant (P<0.0125). Methylation of RASSF1A was associated with the CC genotype of the IL28B gene (P=0.024) and a higher viral load (≥400 000 IU/mL, P=0.009). Our results suggest that combined analysis of RASSF1A gene methylation and IL28B rs12979860 polymorphism could potentially help in the prediction of therapy response in CHC genotype 1b patients.
      PubDate: 2022-04-01
      DOI: 10.2298/ABS211208004K
      Issue No: Vol. 74, No. 1 (2022)
       
  • Bacteriome composition analysis of selected mineral water occurrences in
           Serbia

    • Authors: Vladimir Šaraba, Veselin Dragišić, Tamara Janakiev, Vesna Obradović, Milica Ćopić, Branislav Knežević, Ivica Dimkić
      Pages: 67 - 79
      Abstract: Paper description:
      The composition of bacterial communities and their physicochemical properties can provide insight into the quality status of mineral waters.
      Bacterial diversity of mineral waters was studied by metabarcoding analysis of 16S rDNA. Physicochemical analysis of mineral waters was performed.
      The study provides first insight into the bacterial diversity of selected occurrences based on metabarcoding analysis. Different physiological groups of bacteria were identified among occurrences characterized by higher levels of total dissolved solids and elevated concentrations of chemical compounds.
      The identified bacteria points to the need for further revitalization of the investigated occurrences. Abstract: Bacterial metabarcoding analysis by 16S rDNA of five occurrences of mineral waters in Serbia (Torda, Slankamen Banja, Lomnički Kiseljak, Velika Vrbnica and Obrenovačka Banja) indicated the presence of a high percentage of the Proteobacteria phylum, followed by the Bacteroidetes phylum. The families Rhodobacteraceae, Burkholderiaceae, Pseudomonadaceae, Methylophilaceae and Moraxellaceae were the most dominant in the bacterial flora of the selected occurrences, whereas the most represented genera were Acinetobacter, Pseudorhodobacter, Pseudomonas, Limnohabitans, Massilia, Limnobacter and Methylotenera. The presence of coliform bacteria was not detected. Alpha diversity analysis revealed that Slankamen Banja and Lomnički Kiseljak were the richest of the selected occurrences, while the mineral waters of Torda, Velika Vrbnica and Obrenovačka Banja were characterized by similar diversity of bacterial communities determined by beta diversity analysis. Physical-chemical analysis revealed the value of total dissolved solids above 1 g/L, as well as elevated concentrations of some metals and non-metals. The research concluded that specific bacteria contribute to the development of biocorrosion and biofouling processes of water intake facilities. In addition, some of these bacteria might be potential indicators of the organic sources of pollution and/or biotechnological natural remediators in the treatment of contaminated waters.
      PubDate: 2022-04-01
      DOI: 10.2298/ABS211223005S
      Issue No: Vol. 74, No. 1 (2022)
       
  • Rapid spread of a new alien and potentially invasive species,
           Clathrocaspia knipowitschii (Makarov, 1938) (Gastropoda: Hydrobiidae), in
           the Danube River

    • Authors: József Szekeres, Arne Beermann, Thomas A. Neubauer, Miroslav Očadlík, Momir Paunović, Maja Raković, Béla Csányi, András Varga, Alexander Weigand, Thomas Wilke, Zoltán Fehér
      Pages: 81 - 89
      Abstract: Paper description:
      The non-indigenous freshwater snail Clathrocaspia knipowitschii was detected in the Danube River for the first time in 2013. Since then, the snail has spread along the Danube
      The identity of the species revealed by morphological characters is confirmed by DNA barcoding.
      DNA metabarcoding of bulk samples proved effective in unravelling the distribution of this gastropod. It is necessary to monitor systematically the occurrence and spread of alien species in aquatic ecosystems. Abstract: The distribution and spread of a new alien gastropod species, Clathrocaspia knipowitschii (Makarov, 1938) (Gastropoda: Hydrobiidae: Caspiinae) in the Danube River was examined. First findings of this species for Hungary, Slovakia, Romania, Bulgaria and Serbia are presented. Clathrocaspia knipowitschii was initially found in 2013 in the Iron Gate stretch of the Danube River at the border between Romania and Serbia. In 2019 and 2020, the species was found at several sites in the lower Danube in Romania, Serbia and Bulgaria, and also upstream in the middle Hungarian Danube in high population densities. The species appears to have spread along more than 800 km in six years. This finding together with the available abundance data indicates that C. knipowitschii is potentially an invasive species, but further observations are needed.
      PubDate: 2022-04-01
      DOI: 10.2298/ABS220211006S
      Issue No: Vol. 74, No. 1 (2022)
       
  • Retinoic acid induces hyaluronic acid production through the
           klotho-mediated EGFR signaling pathway in human epidermal keratinocytes

    • Authors: Hyangtae Choi, Yonghee Lee, Won-seok Lee, Beom Joon Kim, Chang Seok Lee
      Pages: 91 - 96
      Abstract: Paper description:
      The relationship between all-trans retinoic acid (RA) and klotho protein in keratinocytes was examined.
      Klotho small interfering RNA (siRNA)-transfected keratinocytes were used to study the effect of klotho on hyaluronic acid production and the epidermal growth factor receptor (EGFR) activated extracellular-signal regulated kinase (ERK) pathway in RA-treated cells.
      RA induced klotho expression, which mediated hyaluronic acid production through the EGFR-ERK signaling pathway.
      RA behaves as an anti-aging reagent that induces hyaluronic acid production via a klotho-dependent pathway. Abstract: All-trans retinoic acid (RA) is an effective anti-aging chemical substance widely used in skin-care products. RA compromises epidermal differentiation and induces keratinocyte proliferation, causing hyaluronic acid production through mechanisms that are not completely understood. Klotho protein causes the differentiation of human epidermal keratinocytes. Klotho gene expression is mediated by epidermal growth factor (EGF), which inhibits cell apoptosis in aging-related diseases. The klotho gene causes human aging syndrome, including short lifespan, skin atrophy, and osteoporosis. We investigated the relationship between RA and klotho in epidermal keratinocytes for the first time. In human epidermal keratinocytes, RA induced klotho gene expression. Treatment with both RA and recombinant klotho induced hyaluronic acid production in human epidermal keratinocytes. However, in klotho small interfering RNA (siRNA)-transfected keratinocytes, RA produced less hyaluronic acid than in the control group, indicating that RA may partially regulate hyaluronic acid production through a klotho-dependent pathway. Knockdown of klotho gene expression inactivated the EGFR-extracellular signal-regulated kinase (ERK) signaling pathway, which is involved in hyaluronic acid production. We concluded that the effect of RA on hyaluronic acid production is partly regulated through the klotho-mediated EGFR signaling pathway in human epidermal keratinocytes.
      PubDate: 2022-04-01
      DOI: 10.2298/ABS220215007C
      Issue No: Vol. 74, No. 1 (2022)
       
  • MiR-548ar-3p increases cigarette smoke extract-induced chronic obstructive
           pulmonary disease (COPD) injury through solute carrier family 17 member 9
           (SLC17A9)

    • Authors: Longju Zhang, Xiaoli Liu, Yi Zheng, Fei Du, Gang He
      Pages: 97 - 105
      Abstract: Paper description:
      The pathogenesis of chronic obstructive pulmonary disease (COPD) caused by smoking is unclear.
      miR-548ar-3p was selected by high-throughput sequencing of peripheral blood from smoking (COPD) and non-smoking (normal) individuals. A miR-548ar-3p mimic was transfected into human bronchial epithelial (HBE) cells and a COPD model was established by treating HBE cells with cigarette smoke extract (CSE). The effect of miR-548ar-3p on cell proliferation, apoptosis and SLC17A9 protein expression was examined.
      miR-548ar-3p was expressed at a lower level in COPD patients. It caused decreased cell viablity, promoted apoptosis and increased SLC17A9 protein expression.
      miR-548ar-3p may aggravate CSE-induced COPD injury through SLC17A9. Abstract: This study investigated the effect of microRNA mir-548ar-3p on cigarette smoke extract (CSE)-induced chronic obstructive pulmonary disease (COPD). High-throughput sequencing was performed on peripheral blood from smoking COPD patients and non-smoking individuals with normal pulmonary function, and miR-548ar-3p RNA, possessing large differential expression was selected. Experimental groups were divided into control, experimental model (EM), EM+mimic miRNA, negative control (NC) and EM+miR-548ar-3p groups; an empty vector or miR-548ar-3p mimic was transfected into human bronchial epithelial (HBE) cells. A COPD model was established by treating HBE cells with CSE. Cell viability, apoptosis and solute carrier family 17 member 9 (SLC17A9) protein expression were examined by cell counting kit-8, flow cytometry and Western blotting, respectively. Cell viability in the EM+miR-548ar-3p group decreased significantly, and the apoptosis rate and SLC17A9 protein expression increased significantly compared with the control (P<0.05, all groups). In smoking COPD patients, interferon (IFN)-γ and interleukin (IL)-17α expression detected by ELISA was significantly higher than in normal individuals. miR-548ar-3p expression was significantly lower (P<0.05, all groups). These findings suggest that miR-548ar-3p was expressed at a lower level in COPD patients. miR-548ar-3p may increase the extent of CSE-induced COPD injury through SLC17A9
      PubDate: 2022-04-01
      DOI: 10.2298/ABS220201008Z
      Issue No: Vol. 74, No. 1 (2022)
       
 
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