Subjects -> BIOLOGY (Total: 3174 journals)
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BIOLOGY (1491 journals)            First | 1 2 3 4 5 6 7 8 | Last

Showing 201 - 400 of 1720 Journals sorted alphabetically
Biological Research     Open Access   (Followers: 1)
Biological Rhythm Research     Hybrid Journal  
Biological Theory     Hybrid Journal   (Followers: 3)
Biological Trace Element Research     Hybrid Journal  
Biologicals     Full-text available via subscription   (Followers: 7)
Biologics: Targets & Therapy     Open Access   (Followers: 1)
Biologie Aujourd'hui     Full-text available via subscription  
Biologie in Unserer Zeit (Biuz)     Hybrid Journal   (Followers: 29)
Biologija     Open Access  
Biology     Open Access   (Followers: 3)
Biology and Philosophy     Hybrid Journal   (Followers: 18)
Biology Bulletin     Hybrid Journal   (Followers: 1)
Biology Bulletin Reviews     Hybrid Journal  
Biology Direct     Open Access   (Followers: 9)
Biology Letters     Full-text available via subscription   (Followers: 45)
Biology Methods and Protocols     Open Access  
Biology of Sex Differences     Open Access   (Followers: 1)
Biology of the Cell     Full-text available via subscription   (Followers: 9)
Biology Open     Open Access  
Biology, Medicine, & Natural Product Chemistry     Open Access   (Followers: 2)
Bioma : Jurnal Ilmiah Biologi     Open Access  
Biomacromolecules     Hybrid Journal   (Followers: 23)
Biomarker Insights     Open Access   (Followers: 2)
Biomarkers     Hybrid Journal   (Followers: 4)
Biomass and Bioenergy     Partially Free   (Followers: 8)
Biomaterials     Hybrid Journal   (Followers: 55)
Biomaterials Advances     Full-text available via subscription   (Followers: 24)
Biomath     Open Access  
Biomatter     Open Access  
Biomechanics and Modeling in Mechanobiology     Hybrid Journal   (Followers: 8)
Biomedical Chromatography     Hybrid Journal   (Followers: 6)
Biomedical Engineering     Hybrid Journal   (Followers: 11)
Biomedical Engineering and Computational Biology     Open Access   (Followers: 11)
BioMedical Engineering OnLine     Open Access   (Followers: 4)
Biomedical Engineering: Applications, Basis and Communications     Hybrid Journal   (Followers: 4)
Biomedical Journal     Open Access   (Followers: 5)
Biomedical Science and Engineering     Open Access   (Followers: 5)
Biomedical Signal Processing and Control     Hybrid Journal   (Followers: 9)
BioMetals     Hybrid Journal   (Followers: 1)
Biometrical Letters     Open Access  
Biometrics     Hybrid Journal   (Followers: 50)
Biometrika     Hybrid Journal   (Followers: 21)
Biomimetic Intelligence and Robotics     Open Access  
Biomolecular NMR Assignments     Hybrid Journal   (Followers: 3)
Biomolecules     Open Access   (Followers: 1)
BioNanoScience     Partially Free   (Followers: 3)
Bionature     Open Access   (Followers: 1)
Biopreservation and Biobanking     Hybrid Journal   (Followers: 2)
Bioprocess and Biosystems Engineering     Hybrid Journal   (Followers: 8)
Bioresource Technology     Partially Free   (Followers: 9)
BioRisk     Open Access   (Followers: 2)
Biosaintifika : Journal of Biology & Biology Education     Open Access  
BioScience     Hybrid Journal   (Followers: 26)
Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science     Hybrid Journal   (Followers: 3)
Biosemiotics     Hybrid Journal   (Followers: 1)
Biosensors     Open Access   (Followers: 3)
Biosensors and Bioelectronics     Hybrid Journal   (Followers: 26)
Biosensors and Bioelectronics : X     Open Access   (Followers: 2)
Bioseparation     Hybrid Journal   (Followers: 1)
Biosfer : Jurnal Biologi dan Pendidikan Biologi     Open Access  
Biosfer : Jurnal Tadris Biologi     Open Access  
BioSocieties     Hybrid Journal   (Followers: 3)
Biospecies     Open Access  
BIOspektrum     Hybrid Journal   (Followers: 4)
Biostatistics     Hybrid Journal   (Followers: 18)
Biosystematics and Ecology     Open Access   (Followers: 5)
Biosystems     Hybrid Journal   (Followers: 3)
Biosystems Diversity     Open Access  
Biota Amazônia     Open Access  
Biota Neotropica     Open Access  
Biotechnology Advances     Hybrid Journal   (Followers: 33)
Biotropia : The Southeast Asian Journal of Tropical Biology     Open Access  
Biotropica     Hybrid Journal   (Followers: 19)
Birth Defects Research     Hybrid Journal  
BJHM Open Research     Full-text available via subscription   (Followers: 4)
BMC Bioinformatics     Open Access   (Followers: 119)
BMC Biology     Open Access   (Followers: 51)
BMC Developmental Biology     Open Access   (Followers: 13)
BMC Evolutionary Biology     Open Access   (Followers: 59)
BMC Genomics     Open Access   (Followers: 69)
BMC Molecular and Cell Biology     Open Access   (Followers: 40)
BMC Proceedings     Full-text available via subscription   (Followers: 2)
BMC Research Notes     Open Access   (Followers: 3)
BMC Structural Biology     Open Access   (Followers: 8)
BMC Systems Biology     Open Access   (Followers: 16)
Boletín Científico : Centro de Museos. Museo de Historia Natural     Open Access  
Boletín del Centro de Investigaciones Biológicas     Open Access  
Boletín Micológico     Open Access  
Bone Reports     Open Access  
Bonorowo Wetlands     Open Access  
Borneo Journal of Resource Science and Technology     Open Access  
Bothalia : African Biodiversity & Conservation     Open Access  
Brain Science Advances     Open Access  
Brazilian Journal of Biological Sciences     Open Access  
Breastfeeding Medicine     Hybrid Journal   (Followers: 20)
Briefings in Bioinformatics     Hybrid Journal   (Followers: 43)
Briefings in Functional Genomics     Hybrid Journal   (Followers: 3)
British Poultry Abstracts     Hybrid Journal   (Followers: 3)
Brittonia     Hybrid Journal  
Bulletin de la Société Royale des Sciences de Liège     Open Access  
Bulletin of Experimental Biology and Medicine     Hybrid Journal  
Bulletin of Mathematical Biology     Hybrid Journal   (Followers: 9)
Bulletin of the Ecological Society of America     Open Access   (Followers: 4)
Bulletin of the Lebedev Physics Institute     Hybrid Journal  
Butlletí de la Institució Catalana d'Història Natural     Open Access  
CABI Agriculture and Bioscience     Open Access   (Followers: 2)
Caldasia     Open Access  
Cameroon Journal of Experimental Biology     Open Access  
Canadian Journal of Bioethics     Open Access  
Canadian Journal of Plant Pathology     Hybrid Journal   (Followers: 3)
Çanakkale Onsekiz Mart University Journal of Marine Sciences and Fisheries     Open Access  
Cancer Biology & Therapy     Open Access   (Followers: 11)
Cancer Cell International     Open Access   (Followers: 7)
Carbon Capture Science & Technology     Open Access  
Carbon Management     Hybrid Journal   (Followers: 5)
Carbon Resources Conversion     Open Access   (Followers: 2)
Caryologia : International Journal of Cytology, Cytosystematics and Cytogenetics     Partially Free  
Caucasiana     Open Access  
Cell     Full-text available via subscription   (Followers: 1153)
Cell Adhesion & Migration     Open Access   (Followers: 9)
Cell and Tissue Banking     Hybrid Journal   (Followers: 1)
Cell and Tissue Biology     Hybrid Journal   (Followers: 4)
Cell and Tissue Research     Hybrid Journal   (Followers: 5)
Cell Biochemistry and Function     Hybrid Journal   (Followers: 7)
Cell Biology and Development     Open Access   (Followers: 3)
Cell Biology and Toxicology     Hybrid Journal   (Followers: 10)
Cell Biology Education     Free   (Followers: 4)
Cell Biology International     Hybrid Journal   (Followers: 4)
Cell Biology International Reports     Hybrid Journal   (Followers: 2)
Cell Calcium     Hybrid Journal   (Followers: 2)
Cell Communication & Adhesion     Hybrid Journal   (Followers: 2)
Cell Cycle     Full-text available via subscription   (Followers: 5)
Cell Death and Differentiation     Hybrid Journal   (Followers: 7)
Cell Discovery     Open Access   (Followers: 2)
Cell Division     Open Access   (Followers: 1)
Cell Genomics     Full-text available via subscription   (Followers: 3)
Cell Metabolism     Full-text available via subscription   (Followers: 58)
Cell Proliferation     Open Access  
Cell Reports     Open Access   (Followers: 62)
Cell Reports Medicine     Open Access   (Followers: 4)
Cell Reports Methods     Open Access   (Followers: 1)
Cell Research     Hybrid Journal   (Followers: 11)
Cell Stress and Chaperones     Hybrid Journal   (Followers: 1)
Cell Surface     Open Access  
Cell Systems     Hybrid Journal   (Followers: 9)
Cells     Open Access   (Followers: 2)
Cells & Development     Hybrid Journal   (Followers: 3)
Cells Tissues Organs     Full-text available via subscription   (Followers: 1)
Cellular Immunology     Hybrid Journal   (Followers: 29)
Cellular Logistics     Full-text available via subscription  
Cellular Microbiology     Hybrid Journal   (Followers: 12)
Cellular Oncology     Hybrid Journal   (Followers: 3)
Cellular Reprogramming     Hybrid Journal  
Cellular Signalling     Hybrid Journal   (Followers: 10)
Ceylon Journal of Science     Open Access  
Channels     Open Access   (Followers: 1)
Check List : The Journal of Biodiversity Data     Open Access   (Followers: 2)
Chem     Hybrid Journal   (Followers: 1)
ChemBioEng Reviews     Full-text available via subscription   (Followers: 3)
Chemosensory Perception     Hybrid Journal  
Chirality     Hybrid Journal  
Chromosoma     Hybrid Journal  
Chromosome Research     Hybrid Journal   (Followers: 2)
Ciencia     Open Access  
Ciencia Amazónica (Iquitos)     Open Access  
Ciência ET Praxis     Open Access  
CienciaUAT     Open Access  
Cladistics     Hybrid Journal   (Followers: 7)
Climate Change Ecology     Open Access   (Followers: 18)
Clinical Dysmorphology     Hybrid Journal  
Clinical Phytoscience     Open Access  
Clinical Proteomics     Open Access   (Followers: 3)
Clinical Spectroscopy     Open Access   (Followers: 1)
Coevolution     Open Access  
Cogent Biology     Open Access  
Cognitive Neurodynamics     Hybrid Journal   (Followers: 2)
Cold Spring Harbor Perspectives in Biology     Full-text available via subscription   (Followers: 4)
Cold Spring Harbor Protocols     Full-text available via subscription   (Followers: 5)
Communication in Biomathematical Sciences     Open Access   (Followers: 2)
Communications Biology     Open Access  
Communications in Applied Sciences     Open Access  
Communications Materials     Open Access  
Communicative & Integrative Biology     Open Access  
Community Ecology     Full-text available via subscription   (Followers: 27)
Comparative Medicine     Full-text available via subscription   (Followers: 5)
Composite Interfaces     Hybrid Journal   (Followers: 6)
Comptes Rendus : Chimie     Open Access  
Comptes Rendus Biologies     Open Access   (Followers: 1)
Computational Biology Journal     Open Access   (Followers: 6)
Computational Mathematics and Mathematical Physics     Hybrid Journal   (Followers: 5)
Computer Methods in Biomechanics and Biomedical Engineering     Hybrid Journal   (Followers: 10)
Computer Methods in Biomechanics and Biomedical Engineering : Imaging & Visualization     Hybrid Journal  
Computers in Biology and Medicine     Hybrid Journal   (Followers: 10)
Connective Tissue Research     Hybrid Journal  
Contact (CTC)     Open Access  
Contributions to Plasma Physics     Hybrid Journal   (Followers: 3)
CRISPR Journal     Hybrid Journal  
Critical Reviews in Clinical Laboratory Sciences     Hybrid Journal   (Followers: 16)
Crustaceana     Hybrid Journal   (Followers: 6)
Cryobiology     Hybrid Journal   (Followers: 3)

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BioNanoScience
Journal Prestige (SJR): 0.308
Citation Impact (citeScore): 1
Number of Followers: 3  
 
  Partially Free Journal Partially Free Journal
ISSN (Print) 2191-1630 - ISSN (Online) 2191-1649
Published by Springer-Verlag Homepage  [2469 journals]
  • Green Synthesis, Characterization and Bio-evaluation of Zirconium
           Nanoparticles Using the Dried Biomass of Sphagneticola trilobata Plant
           Leaf

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      Abstract: The green synthesis of zirconium nanoparticles (Zr-NPs) was carried out via reduction of aqueous zirconyl nitrate using leaf extract of Sphagneticola trilobata under ultrasound irradiations. The synthesized Zr-NPs were characterized by several analytical techniques such as FTIR, XRD, UV–visible spectroscopy, FESEM, and TEM. The characteristic/functional group absorption peak of the Zr-NPs in FTIR was observed at frequency band 3413.93 (due to N–H) and 1071.88 cm−1 (due to C-O) stretching respectively which shows the surface modification of Zr-NPs by organic compounds. The X-ray diffraction pattern Zr-NPs significantly shows a tetragonal structure for metallic zirconium. FESEM images of Zr-NPs indicate the growth of uneven-sized agglomerated nanosheets in the range of 1 µm-100 nm. The TEM images exhibit nanosheets formed from poly-dispersed oval-shaped nanoparticles with particle sizes in the range of 20–100 nm. Electron diffraction pattern reflects crystalline nature; the present synthetic route for zirconium nanoparticles using the dried biomass of Sphagneticola trilobata plant leaf is a greener, efficient, and cost-effective approach. Synthesized Zr-NPs showed antifungal activity (12 mm, zone of inhibition) using Candida albicans and (14 mm) Aspergillus niger, antituberculosis activity (12 mm) using Tuberculosis bacilli, and antimalarial activity (13 mm) using malaria Plasmodium vivax strains. Graphical abstract
      PubDate: 2022-07-01
       
  • Stability Evaluation of dsRNA and DNA Encapsulated in Chitosan
           Nanoparticles

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      Abstract: The polyelectrolyte effect of polysaccharides can be exploited in biotechnological systems for the encapsulation and transport of nucleic acids (NA). The main target applications could be non-viral vaccines and gene silencing. As general application models, this study used plasmid DNA from Xanthomonas citri pv. viticola and dsRNA molecules. Encapsulation occurred by ionotropic gelation based on the pre- and post-addition of NA to the nanoparticle. The suspensions were characterized by UV–visible spectroscopy, electrophoresis, particle size and zeta potential (dynamic light scattering, DLS), and scanning electronic microscopy (SEM). Size distribution was around 173 nm and 587 nm, respectively, for dsRNA and DNA, according to the DLS technique. The post-addition process resulted in small nanoparticles and a more stable suspension, with high zeta potential. The SEM analysis showed spherical nanoparticle and homogeneity in distribution. The degradation study showed that the encapsulation of both dsRNA and DNA resulted in stable nanoparticles when subjected to 80 °C, ultraviolet light, and the action of the RNase enzyme (in the case of dsRNA). Furthermore, stability was still effective in the solid state through the freeze-drying and casting processes. Therefore, dsRNA and DNA nanoencapsulated by ionotropic gelation are feasible, with a high potential for phytopathological application in disease treatment and pest control. Graphical abstract
      PubDate: 2022-06-28
       
  • Green Combustion Synthesis of CeO2 Nanostructure Using Aloe vera (L.) Burm
           f. Leaf Gel and Their Structural, Optical and Antimicrobial Applications

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      Abstract: Abstract  We adopted green synthesis of multifunctional Cerium oxide nanoparticles (CeO2 NPs) by low temperature solution combustion route employing Aloe vera (L.) Burm f. leaf gel as a fuel. The synthesized CeO2 NPs were characterized by PXRD, SEM, and TEM. Results showed that size of NPs between 40 and 50 nm and they found highly crystalline. These NPs were tested in vitro for their antimicrobial activity against four bacteria (Staphylococcus aureus, Enterobacter aerogenes, Pseudomonas aeruginosa and Escherichia coli) and three fungi (Aspergillus niger, A. clavatus and A. flavus). Results showed toxicity against both the tested bacteria and fungi. Maximum zone of inhibition from bacteria and fungi was obtained from 75 µg/ml CeO2 NPs against E. aerogenes (21.67 ± 1.21) and A. flavus (19.00 ± 1.73) respectively. Current investigation explores the green facile method for synthesis of multifunctional rare earth CeO2 NPs with interesting structural and surface morphological and biological studies.
      PubDate: 2022-06-21
       
  • Versatile Applications of Nanosponges in Biomedical Field: A Glimpse on
           SARS-CoV-2 Management

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      Abstract: Abstract Nanotechnology has a versatile use in the field of disease therapy, targeted drug delivery, biosensing, and environmental protection. The cross-linked nanosponges are one of the types of nanostructures that provide huge application in the biomedical field. They are available up to the fourth generation and can act as a payload for both kinds of hydrophilic and hydrophobic drugs. There are different methods available for the synthesis of these nanosponges as well as loading the drugs inside them. A variety of approved drugs based on nanosponges are already in the market including drugs for cancer. Other applications include the uses of nanosponges as topical agent, in improving solubility, as protein carrier, in chemical sensors, in wastewater remediation, and in agriculture. The present review discusses in detail about different applications of nanosponges and also mentions about the recent SARS-CoV-2 management using nanosponges.
      PubDate: 2022-06-20
       
  • Thermosensitive and Biocompatible Nanocomposites of
           Poly(N-vinylcaprolactam) and Hydroxyapatite with Potential Use for Bone
           Tissue Repair

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      Abstract: Abstract Thermosensitive nanocomposites of poly(N-vinylcaprolactam) and hydroxyapatite nanoparticles synthesized by hydrothermal processing were prepared by in situ polymerization in dimethyl sulfoxide, using azobisisobutyronitrile as a radical initiator. Polymerization was performed in the presence of nanoparticles (1% w/w) at 70 °C during 4 h to obtain a new stimuli-responsive biomaterial for medical/dental applications. The biocompatibility of the injectable nanocomposites was verified through the survival ratio and eclosion ratio of zebrafish embryos, which revealed a polymer of low toxicity, showing an average survival ratio of 93% after 96 h of exposition up to 25% of nanocomposites in water. In this sense, this work introduces an injectable hydrogel biomaterial with potential osseointegration properties for bone tissue engineering.
      PubDate: 2022-06-17
       
  • Application of Monoclonal Antibody Drugs in Treatment of COVID-19: a
           Review

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      Abstract: Abstract Coronavirus infection can have various degrees of severity and outcomes. In some cases, it causes excessive production of pro-inflammatory cytokines, a so-called cytokine storm, leading to acute respiratory distress syndrome. Unfortunately, the exact pathophysiology and treatment, especially for severe cases of COVID-19, are still uncertain. Results of preliminary studies showed that immunosuppressive therapy, such as interleukin (IL)-6, IL-1, and TNF-α antagonists commonly used in rheumatology, can be considered as treatment options for COVID-19, especially in severe cases. The review focused on the most common and currently studied monoclonal antibody drugs, as well as up-to-date data on the pathogenesis of COVID-19, host immune response against SARS-CoV-2 and its association with cytokine storm. It also covered effects of interleukin (IL)-6, IL-1, and TNF-α blockers on the course of coronavirus infection and outcome in patients treated for the main autoimmune disease and subsequently infected with COVID-19.
      PubDate: 2022-06-15
       
  • Modelling the Effect of Geometry and Loading on Mechanical Response of
           SARS-CoV-2

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      Abstract: Abstract In recent times, coronavirus (SARS-CoV-2) becomes a pandemic disease across the globe. This virus affects the severe acute respiratory system that causes a type of pneumonia, which results in an outbreak in Wuhan, China, and then in whole global countries. The virus possesses a complex structure and varied in composition along with its geometrical shape and size. Contributions of the lipid and protein components of a virus to the influenza viral envelope’s mechanical properties are still unknown. In this work, the virus is modeled like the SARS-CoV-2 and surrounded with spikes made up of S glycoproteins, and numerical analysis was made to predict its mechanical behavior while resting on the substrate. The static and viscoelastic response of the virus was carried out in a finite element (FE) commercial software Ansys. The impact of changing viral envelope thickness on SARS-CoV-2 and bald virus stiffness was investigated. The viscoelastic analysis shows the increase in the deformation and stress with an increase in the pressure. The static analysis predicts the lower stiffness for SARS-CoV-2 compared to bald virion and increases with the increase in the envelop thickness. This study is useful for analyzing the effect of geometry and mechanical properties on the mechanical response of SARS-CoV-2.
      PubDate: 2022-06-14
       
  • Future of Alzheimer’s Disease: Nanotechnology-Based Diagnostics and
           Therapeutic Approach

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      Abstract: Abstract Alzheimer's disease (AD) is one of the neurodegenerative diseases that leads to the deposition of amyloid plaques in the neuropil as well as outside the cells in the brain leading to sometimes cell death. Even though there are various traditional diagnosis methods, they lack sensitivity towards the detection of AD. FDA has also approved some drugs for the treatment and alleviation of AD severity but they are not capable of curing AD. The use of nanotechnology for biomedical applications such as specific drug delivery vehicles to treat various neurodegenerative disorders including Alzheimer's disease (AD) and also nanotechnology offers highly sensitive nanodiagnostic tools that utilize different nanoparticles/nanostructures. AD therapy utilizing a multifunctional nanotechnology approach could be developed for designing therapeutic cocktails and diagnostic tools (nanosensors, imaging) that simultaneously and specifically target the important molecule involved in AD. The interaction of different functionalized nanostructures used for the therapy of AD and its different physicochemical interactions with the neuronal cells in vitro or in vivo needs to be discussed. In this review, we will briefly discuss about the genes/proteins that are involved in AD and its pathology, traditional AD diagnosis methods such as magnetic resonance imaging, PET scan, in vitro nanodiagnostic methods such as zinc oxide nanoflower platform, surface plasmon resonance nanoparticle, scanning tunnelling microscopy, and QCM-based detection. In vivo nanodiagnostic approaches such as the use of nanoparticles in AD diagnosis with MRI, optical imaging, quantum dots, nanotechnology-based drug delivery systems for the treatment of AD such as solid lipid nanoparticles, liposomes, polymeric nanoparticles, nanogels, fullerenes, nano-ceria, dendrimers, zinc oxide nanoflowers, gold nanoparticles, FDA-approved drugs and nasal route of drug administration for effective AD treatment will also be discussed.
      PubDate: 2022-06-11
       
  • Methods of Chemical Synthesis in the Synthesis of Nanomaterial and
           Nanoparticles by the Chemical Deposition Method: A Review

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      Abstract: Abstract Chemical vapor deposition (CVD) is a vacuum deposition method used to produce high-quality and high-performance solid materials. The process is often used in the semiconductor industry to produce thin films. Microfabrication processes widely use CVD to deposit materials in various forms, including monocrystalline, polycrystalline, amorphous, and epitaxial. These materials include silicon (dioxide, carbide, nitride, oxynitride), carbon (fiber, nanofibers, nanotubes, diamond, and graphene), fluorocarbons, filaments, tungsten, titanium nitride, and various high-k dielectrics. Chemical deposition takes advantage of the chemical reaction where the product self-assembles and deposits on a suitable substrate. Chemical deposition is commonly used for generating thin nanostructured blend films of crystalline inorganic materials, such as ZnS, CuSe, InS, CdS, etc. Depending on the deposition conditions, several terms have been used, such as chemical bath deposition, CVD, and ECD. Depending on the material and the deposition conditions, different surface morphologies have been obtained, from nanopins to nanotubes to nanorods. Reagents in sedimentary reactions are usually water-soluble ionic compounds. When these compounds are dissolved in water, they separate from each other to form anion and cation ions. If a cation of one compound forms an insoluble compound with an anion of another compound, precipitation occurs. Applications of this method include the removal of heavy metals and anions from wastewater, reducing water hardness, and metal recovery. Synthesis processes occur by chemical deposition based on deposition reactions (substitution), co-precipitation, oxidation–reduction, thermolysis, hydrolysis, polymerization, and condensation. The control of various variables in a synthetic system plays an important role in controlling particle size and morphology. The products of sedimentary processes under various synthetic conditions range from coarse crystals to nanostructured colloidal particles. Co-precipitation chemical methods allow the synthesis of metal nanoparticles, metal oxides, as well as many metal semiconductor compounds. Also, a wide range of properties and characteristics can be achieved by changing the synthesis conditions. The basis of these methods is the preparation of products from soluble precursors using different systems such as electrochemical equipment, microwave radiation, ultrasound, and high-energy beams.
      PubDate: 2022-06-03
       
  • Microwave-Assisted Biosynthesized Gold Nanoparticles Using Saussurea
           obvallata: Biocompatibility and Antioxidant Activity Assessment

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      Abstract: Abstract Nanoparticles play a significant role in the development of pharmaceuticals. In the present study, gold nanoparticles (AuNPs) were synthesized using the microwave irradiation method and evaluated their cytocompatibility and antioxidant properties. Saussurea obvallata plant extract was used as a reducing agent to prepare AuNPs. The UV–visible spectra confirmed the formation of AuNPs with the surface plasmon resonance peak at 530 nm. Fourier transform infrared spectroscopy demonstrates that AuNPs were blended with different functional groups, including hydroxyl, amine, and alkyl halide. The scanning electron microscopy and transmission electron microscopy results indicate that AuNPs are spherical in size. The XRD analysis provides evidence for the existence of the AuNPs, which are coherent with standard AuNPs. The synthesized AuNPs showed excellent biocompatibility with IMR-32 cells up to 500 μg/mL concentration. Furthermore, the biosynthesized AuNPs exhibited enhanced antioxidative activity at 1000 μg/mL concentration. Hence, the developed AuNPs would have a potential biological application in the medical field.
      PubDate: 2022-06-03
       
  • Correction to: A Comprehensive Review on Novel Liposomal Methodologies,
           Commercial Formulations, Clinical Trials and Patents

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      PubDate: 2022-06-01
       
  • Correction to: An Ultra-Compact Multi-Band VCO Achieving − 196 dB
           FoMA with Single-Ended Tunable Active Inductor

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      PubDate: 2022-06-01
       
  • Case Report of Gastric Bypass Complicated with Genetic-Associated
           Thrombosis

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      Abstract: Abstract Bariatric surgery is the most effective method of morbid obesity treatment. Venous thrombosis is a rare but serious complication that can occur after bariatric surgery. The article presents a clinical observation of thrombosis in a patient after gastric bypass. A 42-year-old patient underwent gastric bypass surgery for grade 2 obesity (BMI 42 kg/m2). Seven months later, the patient turned to the center for personalized medicine of the Moscow Clinical Scientific Center (MCSC) named after A. S. Loginov complaining of the abdominal volume increase. Ascites development was caused by the portal vein thrombosis detected. There were found mutations in the PAI-1, MTR, and MTRR genes, which are responsible for the tendency to develop thrombosis due to disorder of fibrinolysis and hyperhomocysteinemia. Venous thrombosis after gastric bypass surgery is rare (13.8%). In the case described, the complication occurred within 6 months after treatment, which corresponds to 4% of all cases according to the literature. There was no typical clinical picture in the case (82.7% abdominal pain, 38.2% vomiting, 12.7% fever) Shoar et al. (Surg Obes Relat Dis 14(1):47–59, 2018); Salinas et al. (Surg Endosc 28(4):1083–9, 2014); Goitein et al. (JAMA Surg 148(4):340–6, 2013). The pathogenesis has not been fully studied; however, no risk factors (oral contraceptives, injuries, obesity, smoking, coagulopathy) James et al. (Archives of Surgery 144(6):520-526, 2009) were found in the case described, instead genetic mutations were detected. It is obviously important to timely and comprehensively assess the condition of bariatric patients even before surgery, including detection of genetic mutations.
      PubDate: 2022-06-01
       
  • Changes of Intestinal Permeability («Triple Sugar Test») in Patients
           with Primary Biliary Cholangitis

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      Abstract: Abstract We evaluated intestinal permeability in primary biliary cholangitis (PBC) in our study. Overall, 41 people were included in the cross-sectional study. Intestinal permeability was assessed in 20 patients with PBC and 21 healthy volunteers. Healthy volunteers without a history of liver disease do not drink alcohol and are with normal analysis. Patients’ age is 18 years and above given a diagnosis of PBC based on actual recommendations—EASL (2017). Small intestine permeability was evaluated by ratio of lactulose/mannitol in urine and large bowel permeability was evaluated by level of sucralose in urine (nmol/l), using the method of high-performance liquid chromatography–mass spectrometry. All patients with PBC had increased ratio of lactulose/mannitol (0.106 [0.07; 0.22]; p < 0.001) compared with the control group (0.013 [0.01; 0.025]); level of sucralose was not changed. Patients with PBC with portal hypertension had increased both small intestine permeability (0.076 [0.036; 0.23]; p < 0.05) and large bowel permeability (1091.2 [480; 2176]; p < 0.001) compared with the control group (785.6 [408; 1027.2]).
      PubDate: 2022-06-01
       
  • Miconazole Nitrate–Loaded Solid Lipid Nanoparticle-Based Hydrogel
           Ameliorate Candida albicans Induced Mycoses in Experimental Animals

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      Abstract: Abstract Solid lipid nanoparticles (SLN) encapsulating miconazole nitrate (MCN), with topical administration purposes for effective treatment of fungal skin infections, were formulated by a method that avoids the use of sonication or organic solvents. To facilitate the controlled release and skin targeting potential, the optimized SLN were incorporated into Carbopol hydrogels and characterized for physical appearance, homogeneity, drug content, pH, viscosity, spreadability and in vitro drug release. Based on the above parameters, H-SLN2 formulation containing 0.5% w/w Carbopol 934 was selected as optimized hydrogel formulation. The H-SLN2 formulation was compared with corresponding marketed gel product for in vitro drug release studies, ex vivo skin permeation and retention studies, skin irritation studies and in vivo antifungal activity. Drug release from H-SLN2 followed Korsmeyer-Peppas model with anomalous non-Fickian release mechanism. The skin retention studies across the rat skin revealed 1.63-fold greater retention of MCN in stratum corneum and 1.56-fold more accumulation of MCN in skin, in the case of H-SLN2 compared to marketed product. The in vivo antifungal studies confirmed the higher therapeutic efficacy of H-SLN2 against Candida albicans in comparison to marketed product. The H-SLN2 exhibited physicochemical stability at 5 °C ± 3 °C and 25 °C ± 2 °C/60% RH ± 5% RH up to 6 months. It was concluded that SLN containing Carbopol hydrogel had good skin targeting ability in conjunction with sustained release and drug localized effect, and it may serve as potential carrier for topical delivery of MCN in the effective treatment of cutaneous mycoses.
      PubDate: 2022-06-01
       
  • In Vivo Visualization of Stable Neuroblastoma Cell Lines with
           Overexpression of Firefly Luciferase or Far-Red Fluorescent Protein

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      Abstract: Abstract The development of imaging techniques in the experimental oncology has made it possible to model and continuously monitor growth and development of tumors in vivo. For this purpose, fluorescent or bioluminescent proteins are most commonly introduced into the genome of target cells which in turn can be used to create xenograft tumor models. In our study, SH-SY5Y human neuroblastoma cells were genetically modified with a firefly luciferase ffLuc gene or far-red fluorescent protein Katushka2S gene, and bioluminescence and fluorescence of obtained cells were analyzed in vitro. Then, produced cell lines were used to create xenograft tumor models in vivo. The bioluminescence and fluorescence of the obtained tumor models were evaluated in vivo. When evaluated in vitro, ffLuc bioluminescence was firstly detected within fewer number of SH-SY5Y cells compared to Katushka2S fluorescence. However, after in vivo administration, the fluorescence intensity of SH-SY5Y-Katushka2S cells was significantly higher than the bioluminescence intensity of the same number of SH-SY5Y-ffLuc cells. This may be due to the distribution and limited intracellular availability of a luciferase substrate, which is administered intraperitoneally, and requires further analysis.
      PubDate: 2022-06-01
       
  • Role of Sensor Technology in Detection of the Breast Cancer

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      Abstract: Cancer has proven to be a menace for researchers from the past few decades. Breast cancer is a form of cancer with the second-highest mortality rate in the world. It is the leading form of cancer among women worldwide. Lack of early detection mechanism and detection at terminal stages result in this high mortality rate. Present detection mechanisms, including mammography, x-rays, positron emission tomography, or biopsy, prove to be ineffective in detecting breast cancer at early stages. Sensor technology has given new hope for solving this problem. With the advent of nanotechnology, sensors have become more sensitive, specific, and cost-effective. The sensor innovation has offered to ascend to an excess of sensors that can be utilized for early discovery of breast cancer with high explicitness with backsliding cases in individual breast cancer patients. This review puts light on different sensors developed to detect breast cancer over the past few years. Graphical abstract
      PubDate: 2022-06-01
       
  • Green Synthesis of Bimetallic Au/Ag Nanostructures Using Aqueous Extract
           of Eichhornia crassipes for Antibacterial Activity

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      Abstract: Biosynthesis of nanostructured materials is an arising feature of the interdisciplinary relationship between nanotechnology and biotechnology and acquiring consideration because of developing interest to foster ecologically favorable innovations in material preparation. In the present study, we synthesized an environmentally friendly and green method for the synthesis of gold/silver bimetallic nanostructure using Eichhornia crassipes leaf extract as reducing and capping agent. Au/Ag nanostructures were characterized by UV–Visible spectroscopy, X-ray photoelectron spectroscopy, and power X-ray diffraction. Transmission electron microscopy images also confirmed the formation of Au/Ag nanostructures. Antibacterial activity of Au/Ag nanostructures was studied and it has been found that Ag/Au nanostructure at 100 µM concentration significantly inhibited the bacterial growth of Escherichia coli bacteria. Moreover, the Hoechst 33342 staining method was used to study the effect of Ag/Au nanostructure particles on the morphological changes in breast cancer cell (MDA-MB-231) nucleus. Staining of the Ag/Au nanostructure particle–treated MDA-MB-231 cells (4 h treatments) showed the appearance of emblematic features of apoptosis such as cell membrane blabbing and shrinkage. Graphical
      PubDate: 2022-06-01
       
  • Green Synthesis of Silver Nanoparticles Using Musa balbisiana and Their
           Cytotoxic Effect on HL-60 and SiHa Cancer Cells Through Clathrin-Mediated
           Endocytosis

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      Abstract: We report herein a one-step, biomimetic synthesis of silver nanoparticles (AgNPs) from Musa balbisiana leaf extract having a cytotoxic effect on SiHa and HL-60 cancer cell lines without affecting non-cancerous, healthy peripheral blood mononuclear cells (PBMCs). The EDX analysis of AgNP dispersion, with a peak of 3.2 keV, confirmed the presence of elemental silver with a weight percentage of 54.57%. As is revealed from both SEM and TEM, monodispersed AgNPs were spherical in morphology with a diameter ranging from 11.28 to 87.53 nm with an average size of 12 nm. The diffraction pattern revealed polycrystalline AgNPs with FCC crystal structure. We report increased cytotoxicity accompanied with characteristic morphological change in HL-60 and SiHa, significant reduction in proliferation, increased reactive oxygen species (ROS) generation, and decreased mitochondrial membrane potential (MMP) following AgNP treatment at various doses. No such detrimental cellular impact of AgNPs was observed on healthy PBMCs. Fluorescence microscopy tracked coumarin-loaded AgNP accumulation in lysosomes as well as the nucleus, suggesting that both lysosome and nucleus served as cellular targets of AgNPs. AgNPs were internalized through passive and active pathways and that energy-dependent, clathrin-mediated endocytosis was involved in the trafficking of AgNPs. Our in silico docking studies confirm the binding of AgNPs to adaptor protein 2 on the β2 subunit facilitating clathrin-mediated endocytosis. Graphical abstract
      PubDate: 2022-06-01
       
  • Relationship Between Serum Cytokine Profile and Circulating Neutrophils
           Phenotype in Patients with Benign Ovarian Tumors and Ovarian Cancer

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      Abstract: Abstract Changes in the cytokine microenvironment determine the anti- (N1) and pro-tumor (N2) activity of neutrophils (Nph), which has been shown in multiple in vitro studies. We aimed to evaluate the relationship between serum cytokine profile and circulating Nph phenotype in patients with benign ovarian tumors (BOT) and ovarian cancer (OC). The study included patients with BOT (n = 15), primary stage I–IV OC patients before treatment (n = 63), and healthy donors (n = 22) as a control group. The levels of cytokines were estimated in Nph and blood serum; NF-kBp65 was assessed in the Nph nuclear fraction. The myeloperoxidase (MPO) activity, the ability to generate ROS (spontaneous NBT test), and phagocytosis were assessed in Nph by the cytochemical method. The CD11b+, CD16+, CD64+, CD95+ Nph counts, the neutrophil traps (NETs) generation were assessed by fluorescence microscopy. Atomic force microscopy was used to determine Nph membrane stiffness. Statistical analysis was performed using Statistica 13 (TIBCO, USA). We observed N1 and N2 subpopulations of Nph in patients with BOT and OC, considering the surface markers, cytokine/growth factors expression, and effector functions. Multiple and simple linear regression models allowed us to propose the combinations of serum cytokines which could polarize circulating Nph into pro- and anti-tumor populations, including the cytokines involved in the NF-kB-signaling. According to the logistic regression, analysis could differentiate between OC and BOT. The assessment of circulating N1 and N2 populations may be advantageous to identify the tumor-promoting neutrophil markers and contribute to the development of therapeutic strategies.
      PubDate: 2022-04-18
      DOI: 10.1007/s12668-022-00974-2
       
 
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