Subjects -> BIOLOGY (Total: 3134 journals)
    - BIOCHEMISTRY (239 journals)
    - BIOENGINEERING (143 journals)
    - BIOLOGY (1491 journals)
    - BIOPHYSICS (53 journals)
    - BIOTECHNOLOGY (243 journals)
    - BOTANY (220 journals)
    - CYTOLOGY AND HISTOLOGY (32 journals)
    - ENTOMOLOGY (67 journals)
    - GENETICS (152 journals)
    - MICROBIOLOGY (265 journals)
    - MICROSCOPY (13 journals)
    - ORNITHOLOGY (26 journals)
    - PHYSIOLOGY (73 journals)
    - ZOOLOGY (117 journals)

BIOLOGY (1491 journals)                  1 2 3 4 5 6 7 8 | Last

Showing 1 - 200 of 1720 Journals sorted alphabetically
AAPS Journal     Hybrid Journal   (Followers: 31)
Abasyn Journal of Life Sciences     Open Access   (Followers: 3)
ACS Pharmacology & Translational Science     Hybrid Journal   (Followers: 5)
ACS Synthetic Biology     Hybrid Journal   (Followers: 38)
Acta Biologica Hungarica     Full-text available via subscription   (Followers: 5)
Acta Biologica Marisiensis     Open Access   (Followers: 3)
Acta Biologica Sibirica     Open Access   (Followers: 2)
Acta Biologica Turcica     Open Access   (Followers: 1)
Acta Biomaterialia     Hybrid Journal   (Followers: 31)
Acta Biotheoretica     Hybrid Journal   (Followers: 3)
Acta Chiropterologica     Full-text available via subscription   (Followers: 5)
acta ethologica     Hybrid Journal   (Followers: 7)
Acta Fytotechnica et Zootechnica     Open Access   (Followers: 3)
Acta Ichthyologica et Piscatoria     Open Access   (Followers: 5)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Musei Silesiae, Scientiae Naturales     Open Access  
Acta Neurobiologiae Experimentalis     Open Access  
Acta Scientiae Biological Research     Open Access   (Followers: 1)
Acta Scientiarum. Biological Sciences     Open Access   (Followers: 2)
Acta Scientifica Naturalis     Open Access   (Followers: 4)
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis     Open Access   (Followers: 2)
Acta Universitatis Lodziensis : Folia Biologica et Oecologica     Open Access  
Actualidades Biológicas     Open Access   (Followers: 1)
Advanced Biology     Hybrid Journal   (Followers: 1)
Advanced Health Care Technologies     Open Access   (Followers: 12)
Advanced Journal of Graduate Research     Open Access   (Followers: 1)
Advanced Membranes     Open Access   (Followers: 5)
Advanced Quantum Technologies     Hybrid Journal   (Followers: 3)
Advances in Bioinformatics     Open Access   (Followers: 22)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4)
Advances in Biology     Open Access   (Followers: 12)
Advances in Biomarker Sciences and Technology     Open Access   (Followers: 3)
Advances in Biosensors and Bioelectronics     Open Access   (Followers: 6)
Advances in Cell Biology/ Medical Journal of Cell Biology     Open Access   (Followers: 26)
Advances in Ecological Research     Full-text available via subscription   (Followers: 45)
Advances in Environmental Sciences - International Journal of the Bioflux Society     Open Access   (Followers: 17)
Advances in Enzyme Research     Open Access   (Followers: 10)
Advances in High Energy Physics     Open Access   (Followers: 26)
Advances in Human Biology     Open Access   (Followers: 8)
Advances in Life Science and Technology     Open Access   (Followers: 12)
Advances in Life Sciences     Open Access   (Followers: 5)
Advances in Marine Biology     Full-text available via subscription   (Followers: 29)
Advances in Tropical Biodiversity and Environmental Sciences     Open Access   (Followers: 5)
Advances in Virus Research     Full-text available via subscription   (Followers: 8)
Adversity and Resilience Science : Journal of Research and Practice     Hybrid Journal   (Followers: 3)
African Journal of Ecology     Hybrid Journal   (Followers: 18)
African Journal of Range & Forage Science     Hybrid Journal   (Followers: 12)
AFRREV STECH : An International Journal of Science and Technology     Open Access   (Followers: 3)
Ageing Research Reviews     Hybrid Journal   (Followers: 13)
Aggregate     Open Access   (Followers: 1)
Aging Cell     Open Access   (Followers: 22)
Agrokémia és Talajtan     Full-text available via subscription   (Followers: 2)
AJP Cell Physiology     Hybrid Journal   (Followers: 16)
AJP Endocrinology and Metabolism     Hybrid Journal   (Followers: 26)
AJP Lung Cellular and Molecular Physiology     Hybrid Journal   (Followers: 4)
Al-Kauniyah : Jurnal Biologi     Open Access  
Alasbimn Journal     Open Access   (Followers: 1)
Alces : A Journal Devoted to the Biology and Management of Moose     Open Access  
Alfarama Journal of Basic & Applied Sciences     Open Access   (Followers: 8)
All Life     Open Access   (Followers: 1)
AMB Express     Open Access   (Followers: 1)
Ambix     Hybrid Journal   (Followers: 3)
American Journal of Agricultural and Biological Sciences     Open Access   (Followers: 7)
American Journal of Bioethics     Hybrid Journal   (Followers: 18)
American Journal of Human Biology     Hybrid Journal   (Followers: 17)
American Journal of Medical and Biological Research     Open Access   (Followers: 4)
American Journal of Plant Sciences     Open Access   (Followers: 24)
American Journal of Primatology     Hybrid Journal   (Followers: 17)
American Naturalist     Full-text available via subscription   (Followers: 80)
Amphibia-Reptilia     Hybrid Journal   (Followers: 5)
Anaerobe     Hybrid Journal   (Followers: 3)
Analytical Methods     Hybrid Journal   (Followers: 8)
Analytical Science Advances     Open Access   (Followers: 1)
Anatomia     Open Access   (Followers: 12)
Anatomical Science International     Hybrid Journal   (Followers: 3)
Animal Cells and Systems     Hybrid Journal   (Followers: 5)
Animal Microbiome     Open Access   (Followers: 3)
Animal Models and Experimental Medicine     Open Access  
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale     Full-text available via subscription   (Followers: 2)
Annales Henri Poincaré     Hybrid Journal   (Followers: 2)
Annales Universitatis Mariae Curie-Sklodowska, sectio C – Biologia     Open Access   (Followers: 1)
Annals of Applied Biology     Hybrid Journal   (Followers: 6)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 18)
Annals of Human Biology     Hybrid Journal   (Followers: 5)
Annals of Science and Technology     Open Access   (Followers: 2)
Annual Research & Review in Biology     Open Access  
Annual Review of Biomedical Engineering     Full-text available via subscription   (Followers: 18)
Annual Review of Biophysics     Full-text available via subscription   (Followers: 24)
Annual Review of Cancer Biology     Full-text available via subscription   (Followers: 3)
Annual Review of Cell and Developmental Biology     Full-text available via subscription   (Followers: 44)
Annual Review of Food Science and Technology     Full-text available via subscription   (Followers: 13)
Annual Review of Genomics and Human Genetics     Full-text available via subscription   (Followers: 31)
Annual Review of Phytopathology     Full-text available via subscription   (Followers: 11)
Anthropological Review     Open Access   (Followers: 28)
Antibiotics     Open Access   (Followers: 12)
Antioxidants     Open Access   (Followers: 4)
Antioxidants & Redox Signaling     Hybrid Journal   (Followers: 8)
Antonie van Leeuwenhoek     Hybrid Journal   (Followers: 3)
Anzeiger für Schädlingskunde     Hybrid Journal   (Followers: 1)
Apidologie     Hybrid Journal   (Followers: 4)
Apmis     Hybrid Journal   (Followers: 1)
APOPTOSIS     Hybrid Journal   (Followers: 8)
Applied Biology     Open Access  
Applied Bionics and Biomechanics     Open Access   (Followers: 4)
Applied Phycology     Open Access  
Applied Vegetation Science     Full-text available via subscription   (Followers: 9)
Aquaculture Environment Interactions     Open Access   (Followers: 7)
Aquaculture International     Hybrid Journal   (Followers: 25)
Aquaculture Reports     Open Access   (Followers: 3)
Aquaculture, Aquarium, Conservation & Legislation - International Journal of the Bioflux Society     Open Access   (Followers: 9)
Aquatic Biology     Open Access   (Followers: 9)
Aquatic Ecology     Hybrid Journal   (Followers: 42)
Aquatic Ecosystem Health & Management     Hybrid Journal   (Followers: 16)
Aquatic Science and Technology     Open Access   (Followers: 4)
Aquatic Toxicology     Hybrid Journal   (Followers: 26)
Arabian Journal of Scientific Research / المجلة العربية للبحث العلمي     Open Access  
Archaea     Open Access   (Followers: 3)
Archiv für Molluskenkunde: International Journal of Malacology     Full-text available via subscription   (Followers: 1)
Archives of Biological Sciences     Open Access  
Archives of Microbiology     Hybrid Journal   (Followers: 9)
Archives of Natural History     Hybrid Journal   (Followers: 8)
Archives of Oral Biology     Hybrid Journal   (Followers: 2)
Archives of Virology     Hybrid Journal   (Followers: 6)
Archivum Immunologiae et Therapiae Experimentalis     Hybrid Journal   (Followers: 2)
Arctic     Open Access   (Followers: 8)
Arid Ecosystems     Hybrid Journal   (Followers: 2)
Arquivos do Instituto Biológico     Open Access   (Followers: 1)
Arquivos do Museu Dinâmico Interdisciplinar     Open Access  
Arthropod Structure & Development     Hybrid Journal   (Followers: 2)
Arthropod Systematics & Phylogeny     Open Access   (Followers: 3)
Artificial DNA: PNA & XNA     Hybrid Journal   (Followers: 2)
Artificial Intelligence in the Life Sciences     Open Access  
Asian Bioethics Review     Full-text available via subscription   (Followers: 2)
Asian Journal of Biological Sciences     Open Access   (Followers: 2)
Asian Journal of Biology     Open Access  
Asian Journal of Biotechnology and Bioresource Technology     Open Access  
Asian Journal of Cell Biology     Open Access   (Followers: 4)
Asian Journal of Developmental Biology     Open Access   (Followers: 1)
Asian Journal of Medical and Biological Research     Open Access   (Followers: 3)
Asian Journal of Nematology     Open Access   (Followers: 4)
Asian Journal of Poultry Science     Open Access   (Followers: 3)
Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche     Open Access  
Australian Life Scientist     Full-text available via subscription   (Followers: 2)
Australian Mammalogy     Hybrid Journal   (Followers: 8)
Autophagy     Hybrid Journal   (Followers: 8)
Avian Biology Research     Hybrid Journal   (Followers: 4)
Avian Conservation and Ecology     Open Access   (Followers: 17)
Bacterial Empire     Open Access   (Followers: 1)
Bacteriology Journal     Open Access   (Followers: 2)
Bacteriophage     Full-text available via subscription   (Followers: 2)
Bangladesh Journal of Bioethics     Open Access  
Bangladesh Journal of Plant Taxonomy     Open Access  
Bangladesh Journal of Scientific Research     Open Access  
Berita Biologi     Open Access  
Between the Species     Open Access   (Followers: 2)
BIO Web of Conferences     Open Access  
Bio-Grafía. Escritos sobre la Biología y su enseñanza     Open Access  
Bio-Lectura     Open Access  
BIO-SITE : Biologi dan Sains Terapan     Open Access  
Bioactive Compounds in Health and Disease     Open Access  
Biocatalysis and Biotransformation     Hybrid Journal   (Followers: 5)
BioCentury Innovations     Full-text available via subscription   (Followers: 2)
Biochemistry and Cell Biology     Hybrid Journal   (Followers: 18)
Biochimie     Hybrid Journal   (Followers: 4)
BioControl     Hybrid Journal   (Followers: 2)
Biocontrol Science and Technology     Hybrid Journal   (Followers: 5)
Biodemography and Social Biology     Hybrid Journal   (Followers: 1)
BIODIK : Jurnal Ilmiah Pendidikan Biologi     Open Access  
BioDiscovery     Open Access   (Followers: 2)
Biodiversitas : Journal of Biological Diversity     Open Access   (Followers: 2)
Biodiversity : Research and Conservation     Open Access   (Followers: 30)
Biodiversity Data Journal     Open Access   (Followers: 8)
Biodiversity Informatics     Open Access   (Followers: 3)
Biodiversity Information Science and Standards     Open Access   (Followers: 2)
Biodiversity Observations     Open Access   (Followers: 2)
Bioeduca : Journal of Biology Education     Open Access   (Followers: 1)
Bioeduscience     Open Access   (Followers: 2)
Bioeksperimen : Jurnal Penelitian Biologi     Open Access  
Bioelectrochemistry     Hybrid Journal   (Followers: 1)
Bioelectromagnetics     Hybrid Journal   (Followers: 1)
Bioenergy Research     Hybrid Journal   (Followers: 3)
Bioengineering and Bioscience     Open Access   (Followers: 1)
BioEssays     Hybrid Journal   (Followers: 11)
Bioethica     Open Access   (Followers: 1)
Bioethics     Hybrid Journal   (Followers: 21)
BioéthiqueOnline     Open Access   (Followers: 1)
Biogeographia : The Journal of Integrative Biogeography     Open Access   (Followers: 2)
Biogeosciences (BG)     Open Access   (Followers: 17)
Biogeosciences Discussions (BGD)     Open Access   (Followers: 4)
Bioinformatics     Hybrid Journal   (Followers: 283)
Bioinformatics Advances : Journal of the International Society for Computational Biology     Open Access   (Followers: 3)
Bioinformatics and Biology Insights     Open Access   (Followers: 13)
Biointerphases     Open Access   (Followers: 1)
Biojournal of Science and Technology     Open Access  
BioLink : Jurnal Biologi Lingkungan, Industri, Kesehatan     Open Access  
Biologia     Hybrid Journal   (Followers: 1)
Biologia Futura     Hybrid Journal  
Biologia on-line : Revista de divulgació de la Facultat de Biologia     Open Access  
Biological Bulletin     Partially Free   (Followers: 6)
Biological Control     Hybrid Journal   (Followers: 6)

        1 2 3 4 5 6 7 8 | Last

Similar Journals
Journal Cover
Biochemistry and Cell Biology
Journal Prestige (SJR): 0.856
Citation Impact (citeScore): 2
Number of Followers: 18  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0829-8211 - ISSN (Online) 1208-6002
Published by NRC Research Press Homepage  [19 journals]
  • Dysregulation of insulin-like growth factor-1 signaling in postnatal bone
           elongation

    • Free pre-print version: Loading...

      Authors: Cassaundra A. White, Maria A. Serrat
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Insulin-like growth factor-1 (IGF-1) is a critical modulator of cell growth and survival, making it a central part of maintaining essentially every biological system in the body. Knowledge of the intricate mechanisms involved in activating IGF-1 signaling is not only key to understanding basic processes of growth and development, but also for addressing diseases, such as cancer and diabetes. This brief review explores how dysregulation of normal IGF-1 signaling can impact growth by examining its role in postnatal bone elongation. IGF-1 actions are dysregulated in autoimmune diseases, such as juvenile idiopathic arthritis and chronic kidney disease, which results in growth stunting. Conversely, childhood obesity results in growth acceleration, premature growth cessation, and ultimately, diminished bone quality, while systemic IGF-1 levels remain normal. Understanding the role of IGF-1 signaling in normal and dysregulated growth can add to other studies that address how this system regulates chronic diseases.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-05-29T07:00:00Z
      DOI: 10.1139/bcb-2023-0025
       
  • Remembering the legacy of Professor Mohammad Hashemi: a pioneer in
           molecular genetic studies in southeast Iran (1965–2019)

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      Authors: Farhad Tabasi, Ebrahim Eskandari, Saeid Ghavmi
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Professor Mohammad Hashemi was a clinical biochemist and cancer genetic scientist. He has been chair and head of Department of Clinical Biochemistry at Zahedan University of Medical Sciences, Zahedan, Iran. He has played an important role in the improvement of understanding of genetics of disease in southeast Iran. He was also a part of international team for the discovery of the role of calprotectin (S100A8/A9) in cancer biology via regulation of cell fate in tumor cells. He had over 300 peer-reviewed scientific publications and trained significant numbers of high quality personals (>40) in the field of biomedical sciences. His sudden death in 2019 shocked national and international scientific society but his scientific legacy will remain alive forever.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-05-29T07:00:00Z
      DOI: 10.1139/bcb-2023-0116
       
  • Message from Dr. Philippe T. Georgel, Guest Editor for the Marshall
           University Collection, Brad D. Smith, President of Marshall University,
           and Dr. Anivandan Mukherjee, Provost of Marshall University

    • Free pre-print version: Loading...

      Authors: Philippe T. Georgel, Brad D. Smith, Avinandan Mukherjee
      Abstract: Biochemistry and Cell Biology, Ahead of Print.

      Citation: Biochemistry and Cell Biology
      PubDate: 2023-04-13T07:00:00Z
      DOI: 10.1139/bcb-2023-0072
       
  • Evaluation of biochemical profile and oxidative damage to lipids and
           proteins in patients with lysosomal acid lipase deficiency

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      Authors: Gilian Guerreiro, Marion Deon, Carmen Regla Vargas
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Lysosomal acid lipase deficiency (LALD) is an inborn error of metabolism that lacks satisfactory treatment, which leads to the development of severe hepatic and cardiac complications and may even lead to death. In this sense, knowledge of the mechanisms involved in the pathophysiology of this disorder becomes essential to allow the search for new therapeutic strategies. There are no studies in the literature investigating the role of reactive species and inflammatory processes in the pathophysiology of this disorder. Therefore, the aim of this work was to investigate parameters of oxidative and inflammatory stress in LALD patients. In this work, we obtained results that demonstrate that LALD patients are susceptible to oxidative stress caused by an increase in the production of free radicals, observed by the increase of 2-7-dihydrodichlorofluorescein. The decrease in sulfhydryl content reflects oxidative damage to proteins, as well as a decrease in antioxidant defenses. Likewise, the increase in urinary levels of di-tyrosine observed also demonstrates oxidative damage to proteins. Furthermore, the determination of chitotriosidase activity in the plasma of patients with LALD was significantly higher, suggesting a pro-inflammatory state. An increase in plasma oxysterol levels was observed in patients with LALD, indicating an important relationship between this disease and cholesterol metabolism and oxidative stress. Also, we observed in LALD patients increased levels of nitrate production. The positive correlation found between oxysterol levels and activity of chitotriosidase in these patients indicates a possible link between the production of reactive species and inflammation. In addition, an increase in lipid profile biomarkers such as total and low-density lipoprotein cholesterol were demonstrated in the patients, which reinforces the involvement of cholesterol metabolism. Thus, we can assume that, in LALD, oxidative and nitrosative damage, in addition to inflammatory process, play an important role in its evolution and future clinical manifestations. In this way, we can suggest that the study of the potential benefit of the use of antioxidant and anti-inflammatory substances as an adjuvant tool in the treatment will be important, which should be associated with the already recommended therapy.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-04-12T07:00:00Z
      DOI: 10.1139/bcb-2022-0330
       
  • Expression of concern: MicroRNA-518-3p suppresses cell proliferation,
           invasiveness, and migration in colorectal cancer via targeting TRIP4

    • Free pre-print version: Loading...

      Abstract: Biochemistry and Cell Biology, Ahead of Print.

      Citation: Biochemistry and Cell Biology
      PubDate: 2023-04-12T07:00:00Z
      DOI: 10.1139/bcb-2023-0097
       
  • Analysis of financial challenges faced by graduate students in Canada

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      Authors: Sarah Jane Laframboise, Thomas Bailey, Anh-Thu Dang, Mercedes Rose, Zier Zhou, Matthew D. Berg, Stephen Holland, Sami Aftab Abdul, Kaela O'Connor, Sara El-Sahli, Dominique M. Boucher, Garrett Fairman, Jacky Deng, Katherine Shaw, Nathaniel Noblett, Alexa D’Addario, Madelaine Empey, Keaton Sinclair
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Graduate students are vital to the creation of research and innovation in Canada. The National Graduate Student Finance Survey was launched in 2021 by the Ottawa Science Policy Network to investigate the financial realities of Canadian graduate students. Closing in April 2022, the survey received 1305 responses from graduate students representing various geographical locations, years of study, fields of education, and demographic backgrounds. The results capture a snapshot into graduate student finances, including an in-depth analysis of stipends, scholarships, debt, tuition, and living expenses. In its entirety, we found that the majority of graduate students are facing serious financial concerns. This is largely due to stagnant funding for students both from federal and provincial granting agencies and from within their institutions. This reality is even worse for international students, members of historically underrepresented communities, and those with dependents, all of whom experience additional challenges that impact their financial security. Based on our findings, we propose several recommendations to the Tri-Council agencies (Natural Sciences and Engineering Research Council, Social Science and Humanities Research Council, and Canadian Institute for Health Research) and academic institutions to strengthen graduate student finances and help sustain the future of research in Canada.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-04-11T07:00:00Z
      DOI: 10.1139/bcb-2023-0021
       
  • Retraction: Profibrogenic phenotype in caveolin-1 deficiency via
           differential regulation of STAT-1/3 proteins

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      Abstract: Biochemistry and Cell Biology, Ahead of Print.

      Citation: Biochemistry and Cell Biology
      PubDate: 2023-04-11T07:00:00Z
      DOI: 10.1139/bcb-2023-0089
       
  • Mechanism of myocardial fibrosis regulation by IGF-1R in atrial
           fibrillation through the PI3K/Akt/FoxO3a pathway

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      Authors: Pei Zhang, Huilin Li, An Zhang, Xiao Wang, Qiyuan Song, Zhan Li, Weizong Wang, Jingwen Xu, Yinglong Hou, Yong Zhang
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Atrial structural remodeling takes on a critical significance to the occurrence and maintenance of atrial fibrillation (AF). As revealed by recent data, insulin-like growth factor-1 receptor (IGF-1R) plays a certain role in tissue fibrosis. In this study, the mechanism of IGF-1R in atrial structural remodeling was examined based on in vivo and in vitro experiments. First, cluster analysis of AF hub genes was conducted, and then the molecular mechanism was proposed by which IGF-1R regulates myocardial fibrosis via the PI3K/Akt/FoxO3a pathway. Subsequently, the mentioned mechanism was verified in human cardiac fibroblasts (HCFs) and rats transduced with IGF-1 overexpression type 9 adeno-associated viruses. The results indicated that IGF-1R activation up-regulated collagen Ⅰ protein expression and Akt phosphorylation in HCFs and rat atrium. The administration of LY294002 reversed the above phenomenon, improved the shortening of atrial effective refractory period, and reduced the increased incidence of AF and atrial fibrosis in rats. The transfection of FoxO3a siRNA reduced the anti-fibrotic effect of LY294002 in HCFs. The above data revealed that activation of IGF-1R takes on a vital significance to atrial structural remodeling by facilitating myocardial fibrosis and expediting the occurrence and maintenance of AF through the regulation of the PI3K/Akt/FoxO3a signaling pathway.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-04-05T07:00:00Z
      DOI: 10.1139/bcb-2022-0199
       
  • AKT1 participates in ferroptosis vulnerability by driving autophagic
           degradation of FTH1 in cisplatin-resistant ovarian cancer

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      Authors: Zhikun Shi, Hao Yuan, Lanqing Cao, Yang Lin
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Resistance to cisplatin (DDP)-based chemotherapy is an important reason for the failure of ovarian cancer treatment. However, tumor cells resistant to chemotherapy may expose vulnerability to other cell death pathways. Here, we found that DDP-resistant ovarian cancer cells are more susceptible to erastin-induced ferroptosis. It should be noted that this vulnerability does not depend on the weakening of classical ferroptosis defense proteins, but is caused by the reduction of ferritin heavy chain (FTH1). DDP-resistant ovarian cancer cells maintain a high level of autophagy to escape the pressure of chemotherapy, which ultimately leads to increased autophagic degradation of FTH1. We further revealed that the loss of AKT1 was the reason for the increased autophagy level of DDP-resistant ovarian cancer cells. Our study provides new insights into reversing DDP resistance in ovarian cancer by targeting ferroptosis pathway, and AKT1 may be a molecular marker of susceptibility to ferroptosis.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-04-03T07:00:00Z
      DOI: 10.1139/bcb-2022-0361
       
  • Telomere biology and ribosome biogenesis: structural and functional
           interconnections

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      Authors: Liia R. Valeeva, Liliia R. Abdulkina, Inna A. Agabekian, Eugene V. Shakirov
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Telomeres are nucleoprotein structures that play a pivotal role in the protection and maintenance of eukaryotic chromosomes. Telomeres and the enzyme telomerase, which replenishes telomeric DNA lost during replication, are important factors necessary to ensure continued cell proliferation. Cell proliferation is also dependent on proper and efficient protein synthesis, which is carried out by ribosomes. Mutations in genes involved in either ribosome biogenesis or telomere biology result in cellular abnormalities and can cause human genetic diseases, defined as ribosomopathies and telomeropathies, respectively. Interestingly, recent discoveries indicate that many of the ribosome assembly and rRNA maturation factors have additional noncanonical functions in telomere biology. Similarly, several key proteins and enzymes involved in telomere biology, including telomerase, have unexpected roles in rRNA transcription and maturation. These observations point to an intriguing cross-talk mechanism potentially explaining the multiple pleiotropic symptoms of mutations in many causal genes identified in various telomeropathy and ribosomopathy diseases. In this review, we provide a brief summary of eukaryotic telomere and rDNA loci structures, highlight several universal features of rRNA and telomerase biogenesis, evaluate intriguing interconnections between telomere biology and ribosome assembly, and conclude with an assessment of overlapping features of human diseases of telomeropathies and ribosomopathies.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-03-29T07:00:00Z
      DOI: 10.1139/bcb-2022-0383
       
  • Astrocyte-specific Ca2+ activity: Mechanisms of action, experimental
           tools, and roles in ethanol-induced dysfunction

    • Free pre-print version: Loading...

      Authors: O.R. Coulter, C.D. Walker, M.-L. Risher
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Astrocytes are a subtype of non-neuronal glial cells that reside in the central nervous system. Astrocytes have extensive peripheral astrocytic processes that ensheathe synapses to form the tripartite synapse. Through a multitude of pathways, astrocytes can influence synaptic development and structural maturation, respond to neuronal signals, and modulate synaptic transmission. Over the last decade, strong evidence has emerged demonstrating that astrocytes can influence behavioral outcomes in various animal models of cognition. However, the full extent of how astrocytes influence brain function is still being revealed. Astrocyte calcium (Ca2+) signaling has emerged as an important driver of astrocyte-neuronal communication allowing intricate crosstalk through mechanisms that are still not fully understood. Here, we will review the field's current understanding of astrocyte Ca2+ signaling and discuss the sophisticated state-of-the-art tools and approaches used to continue unraveling astrocytes' interesting role in brain function. Using the field of pre-clinical ethanol (EtOH) studies in the context of alcohol use disorder, we focus on how these novel approaches have helped to reveal an important role for astrocyte Ca2+ function in regulating EtOH consumption and how astrocyte Ca2+ dysfunction contributes to the cognitive deficits that emerge after EtOH exposure in a rodent model.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-03-29T07:00:00Z
      DOI: 10.1139/bcb-2023-0008
       
  • Retraction: Wnt5A regulates the expression of ROR2 tyrosine kinase
           receptor in ovarian cancer cells

    • Free pre-print version: Loading...

      Abstract: Biochemistry and Cell Biology, Ahead of Print.

      Citation: Biochemistry and Cell Biology
      PubDate: 2023-03-28T07:00:00Z
      DOI: 10.1139/bcb-2023-0066
       
  • Retraction: MiR-204 suppresses cell proliferation and promotes apoptosis
           in ovarian granulosa cells via targeting TPT1 in polycystic ovary syndrome
           

    • Free pre-print version: Loading...

      Abstract: Biochemistry and Cell Biology, Ahead of Print.

      Citation: Biochemistry and Cell Biology
      PubDate: 2023-03-28T07:00:00Z
      DOI: 10.1139/bcb-2023-0070
       
  • Retraction: Role of the TSLP–DC–OX40L pathway in asthma pathogenesis
           and airway inflammation in mice

    • Free pre-print version: Loading...

      Abstract: Biochemistry and Cell Biology, Ahead of Print.

      Citation: Biochemistry and Cell Biology
      PubDate: 2023-03-28T07:00:00Z
      DOI: 10.1139/bcb-2023-0071
       
  • Retraction: MiR-301b promotes the proliferation, mobility, and
           epithelial-to-mesenchymal transition of bladder cancer cells by targeting
           EGR1

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      Abstract: Biochemistry and Cell Biology, Ahead of Print.

      Citation: Biochemistry and Cell Biology
      PubDate: 2023-03-28T07:00:00Z
      DOI: 10.1139/bcb-2023-0074
       
  • Retraction: MicroRNA-181 inhibits proliferation and promotes apoptosis of
           chondrocytes in osteoarthritis by targeting PTEN

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      Abstract: Biochemistry and Cell Biology, Ahead of Print.

      Citation: Biochemistry and Cell Biology
      PubDate: 2023-03-27T07:00:00Z
      DOI: 10.1139/bcb-2023-0069
       
  • Retraction: Lentivirus-mediated angiopoietin-2 gene silencing decreases
           TNF-α induced apoptosis of alveolar epithelium cells

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      Abstract: Biochemistry and Cell Biology, Ahead of Print.

      Citation: Biochemistry and Cell Biology
      PubDate: 2023-03-24T07:00:00Z
      DOI: 10.1139/bcb-2023-0068
       
  • Retraction: Interaction between miR-572 and PPP2R2C, and their effects on
           the proliferation, migration, and invasion of nasopharyngeal carcinoma
           (NPC) cells

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      Abstract: Biochemistry and Cell Biology, Ahead of Print.

      Citation: Biochemistry and Cell Biology
      PubDate: 2023-03-23T07:00:00Z
      DOI: 10.1139/bcb-2023-0061
       
  • High concentrations of fructose cause brain damage in mice

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      Authors: Anderson Cargnin-Carvalho, Mariella Reinol da Silva, Ana Beatriz Costa, Nicole Alessandra Engel, Bianca Xavier Farias, Joice Benedet Bressan, Kassiane Mathiola Backes, Francielly de Souza, Naiana da Rosa, Aloir Neri de Oliveira Junior, Mariana Pereira de Souza Goldim, Maria Eduarda Anastácio Borges Correa, Ligia Milanez Venturini, Jucélia Jeremias Fortunato, Josiane Somariva Prophiro, Fabrícia Petronilho, Paulo Cesar Lock Silveira, Gabriela Kozuchovsk Ferreira, Gislaine Tezza Rezin
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Excessive fructose consumption is associated with the incidence of obesity and systemic inflammation, resulting in increased oxidative damage and failure to the function of brain structures. Thus, we hypothesized that fructose consumption will significantly increase inflammation, oxidative damage, and mitochondrial dysfunction in the mouse brain and, consequently, memory damage. The effects of different fructose concentrations on inflammatory and biochemical parameters in the mouse brain were evaluated. Male Swiss mice were randomized into four groups: control, with exclusive water intake, 5%, 10%, and 20% fructose group. The 10% and 20% fructose groups showed an increase in epididymal fat, in addition to higher food consumption. Inflammatory markers were increased in epididymal fat and in some brain structures. In the evaluation of oxidative damage, it was possible to observe significant increases in the hypothalamus, prefrontal cortex, and hippocampus. In the epididymal fat and in the prefrontal cortex, there was a decrease in the activity of the mitochondrial respiratory chain complexes and an increase in the striatum. Furthermore, short memory was impaired in the 10% and 20% groups but not long memory. In conclusion, excess fructose consumption can cause fat accumulation, inflammation, oxidative damage, and mitochondrial dysfunction, which can damage brain structures and consequently memory.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-03-22T07:00:00Z
      DOI: 10.1139/bcb-2022-0088
       
  • SARS-CoV-2 E protein-induced THP-1 pyroptosis is reversed by Ruscogenin

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      Authors: Houda Huang, Xiuzhen Li, Duoduo Zha, Hongru Lin, Lingyi Yang, Yihan Wang, Luyan Xu, Linsiqi Wang, Tianhua Lei, Zhou Zhou, Yun-Fei Xiao, Hong-Bo Xin, Mingui Fu, Yisong Qian
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an emerging pathogenic coronavirus, has been reported to cause excessive inflammation and dysfunction in multiple cells and organs, but the underlying mechanisms remain largely unknown. Here we showed exogenous addition of SARS-CoV-2 envelop protein (E protein) potently induced cell death in cultured cell lines, including THP-1 monocytic leukemia cells, endothelial cells, and bronchial epithelial cells, in a time- and concentration-dependent manner. SARS-CoV-2 E protein caused pyroptosis-like cell death in THP-1 and led to GSDMD cleavage. In addition, SARS-CoV-2 E protein upregulated the expression of multiple pro-inflammatory cytokines that may be attributed to activation of NF-κB, JNK and p38 signal pathways. Notably, we identified a natural compound, Ruscogenin, effectively reversed E protein-induced THP-1 death via inhibition of NLRP3 activation and GSDMD cleavage. In conclusion, these findings suggested that Ruscogenin may have beneficial effects on preventing SARS-CoV-2 E protein-induced cell death and might be a promising treatment for the complications of COVID-19.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-03-16T07:00:00Z
      DOI: 10.1139/bcb-2022-0359
       
  • Hedgehog signal activates AMPK via Smoothened to promote autophagy and
           lipid degradation in hepatocytes

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      Authors: Yixing Yao, Tianyuan Li, Tingting Yu, Xin Yang, Yue Wang, Jing Cai, Steven Y. Cheng, Chen Liu, Shen Yue
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Studies in the past decade have shown that lipid droplets stored in liver cells under starvation are encapsulated by autophagosomes and fused to lysosomes via the endocytic system. Autophagy responds to a variety of environmental factors inside and outside the cell, so it has a complex signal regulation network. To this end, we first explored the role of Hedgehog (Hh) in autophagy and lipid metabolism. Treatment of normal mouse liver cells with SAG and GDC-0449 revealed elevated phosphorylation of AMP-activated protein kinase (AMPK) and increased lipidation of LC3. SAG, and GDC-0449 were agonist and antagonist of Smoothened (Smo) in canonical Hh pathway, respectively, but they played a consistent role in the regulation of autophagy in hepatocytes. Moreover, SAG and GDC-0449 did not affect the expression of glioma-associated oncogene (Gli1) and patched 1, suggesting the absence of canonical Hh signaling in hepatocytes. We further knocked down the Smo and found that the effects of SAG and GDC-0449 disappeared, indicating that the non-canonical Smo pathway was involved in the regulation of autophagy in hepatocytes. In addition, SAG and GDC-0449 promoted lipid degradation and inhibited lipid production signals. Knockdown of Smo slowed down the rate of lipid degradation rather than Sufu or Gli1, indicating that Hh signaling regulated the lipid metabolism via Smo. In summary, activates AMPK via Smo to promote autophagy and lipid degradation.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-02-23T08:00:00Z
      DOI: 10.1139/bcb-2022-0345
       
  • Mitogen- and stress-activated protein kinase (MSK1/2) regulated gene
           expression in normal and disease states

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      Authors: Hedieh Sattarifard, Akram Safaei, Enzhe Khazeeva, Mojgan Rastegar, James R. Davie
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      The mitogen- and stress-activated protein kinases (MSK) are epigenetic modifiers that regulate gene expression in normal and disease cell states. MSK1 and 2 are involved in a chain of signal transduction events bringing signals from the external environment of a cell to specific sites in the genome. MSK1/2 phosphorylate histone H3 at multiple sites, resulting in chromatin remodeling at regulatory elements of target genes and the induction of gene expression. Several transcription factors (RELA of NF-κB and CREB) are also phosphorylated by MSK1/2 and contribute to induction of gene expression. In response to signal transduction pathways, MSK1/2 can stimulate genes involved in cell proliferation, inflammation, innate immunity, neuronal function, and neoplastic transformation. Abrogation of the MSK-involved signaling pathway is among the mechanisms by which pathogenic bacteria subdue the host’s innate immunity. Depending on the signal transduction pathways in play and the MSK-targeted genes, MSK may promote or hinder metastasis. Thus, depending on the type of cancer and genes involved, MSK overexpression may be a good or poor prognostic factor. In this review, we focus on mechanisms by which MSK1/2 regulate gene expression, and recent studies on their roles in normal and diseased cells.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-02-22T08:00:00Z
      DOI: 10.1139/bcb-2022-0371
       
  • Structural features, intrinsic disorder, and modularity of a pyriform
           spidroin 1 core repetitive domain

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      Authors: Jeffrey R. Simmons, Geneviève Gasmi-Seabrook, Jan K. Rainey
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Orb-weaving spiders produce up to seven silk types, each with distinct biological roles, protein compositions, and mechanics. Pyriform (or piriform) silk is composed of pyriform spidroin 1 (PySp1) and is the fibrillar component of attachment discs that attach webs to substrates and to each other. Here, we characterize the 234-residue repeat unit (the “Py unit”) from the core repetitive domain of Argiope argentata PySp1. Solution-state nuclear magnetic resonance (NMR) spectroscopy-based backbone chemical shift and dynamics analysis demonstrate a structured core flanked by disordered tails, structuring that is maintained in a tandem protein of two connected Py units, indicative of structural modularity of the Py unit in the context of the repetitive domain. Notably, AlphaFold2 predicts the Py unit structure with low confidence, echoing low confidence and poor agreement to the NMR-derived structure for the Argiope trifasciata aciniform spidroin (AcSp1) repeat unit. Rational truncation, validated through NMR spectroscopy, provided a 144-residue construct retaining the Py unit core fold, enabling near-complete backbone and side chain 1H, 13C, and 15N resonance assignment. A six α-helix globular core is inferred, flanked by regions of intrinsic disorder that would link helical bundles in tandem repeat proteins in a beads-on-a-string architecture.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-02-21T08:00:00Z
      DOI: 10.1139/bcb-2022-0338
       
  • ERCC6 plays a promoting role in the progression of non-small cell lung
           cancer

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      Authors: Hui Luo, Zhehao Xiao, Cheng Huang, Wei Wu, Qingbin Xie
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Although excision repair cross-complementing group 6 (ERCC6) has been reported to be associated with lung cancer risk, the specific roles of ERCC6 in non-small cell lung cancer (NSCLC) progression are inadequately studied. Thus, this study aimed to examine the potential functions of ERCC6 in NSCLC. The expression of ERCC6 in NSCLC was analyzed by immunohistochemical staining and quantitative PCR. Celigo cell count, colony formation, flow cytometry, wound-healing, and transwell assays were used to evaluate the effects of ERCC6 knockdown on the proliferation, apoptosis, and migration of NSCLC cells. The effect of ERCC6 knockdown on tumor-forming ability of NSCLC cells was estimated by establishing xenograft model. ERCC6 was highly expressed in NSCLC tumor tissues and cell lines, and high ERCC6 expression was significantly associated with poor overall survival. Additionally, ERCC6 knockdown significantly suppressed cell proliferation, colony formation and migration, while accelerated cell apoptosis of NSCLC cells in vitro. Moreover, ERCC6 knockdown inhibited tumor growth in vivo. Further studies verified that ERCC6 knockdown attenuated the expression levels of Bcl-w, CCND1, and c-Myc. Altogether, these data unveil a major role of ERCC6 in the progression of NSCLC, and ERCC6 is expected to become a novel therapeutic target for NSCLC treatment.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-02-21T08:00:00Z
      DOI: 10.1139/bcb-2022-0220
       
  • Lipid-induced alteration in retinoic acid signaling leads to mitochondrial
           dysfunction in HepG2 and Huh7 cells

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      Authors: Eshani Karmakar, Nabanita Das, Bidisha Mukherjee, Prosenjit Das, Satinath Mukhopadhyay, Sib Sankar Roy
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      A surfeit of mitochondrial reactive oxygen species (ROS) and inflammation serve as obligatory mediators of lipid-associated hepatocellular maladies. While retinoid homeostasis is essential in restoring systemic energy balance, its role in hepatic mitochondrial function remains elusive. The role of lecithin-retinol acyltransferase (LRAT) in maintenance of retinoid homeostasis is appreciated earlier; however, its role in modulating retinoic acid (RA) bioavailability upon lipid-imposition is unexplored. We identified LRAT overexpression in high-fat diet (HFD)-fed rats and palmitate-treated hepatoma cells. Elevation in LRAT expression depletes RA production and deregulates RA signaling. This altered RA metabolism enhances fat accumulation, accompanied by inflammation that leads to impaired mitochondrial function through enhanced ROS generation. Hence, LRAT inhibition could be a novel approach preventing lipid-induced mitochondrial dysfunction in hepatoma cells.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-02-14T08:00:00Z
      DOI: 10.1139/bcb-2022-0266
       
  • GCN5 regulates ZBTB16 through acetylation, mediates osteogenic
           differentiation, and affects orthodontic tooth movement

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      Authors: Shu-Man Shi, Ting-Ting Liu, Xue-Qin Wei, Ge-Hong Sun, Lin Yang, Juan-Fang Zhu
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      In the process of orthodontic tooth movement (OTM), periodontal ligament fibroblasts (PDLFs) must undergo osteogenic differentiation. OTM increased the expression of Zinc finger and BTB domain-containing 16 (ZBTB16), which is implicated in osteogenic differentiation. Our goal was to investigate the mechanism of PDLF osteogenic differentiation mediated by ZBTB16. The OTM rat model was established, and PDLFs were isolated and exposed to mechanical force. Hematoxylin–eosin staining, Alizarin Red staining, immunofluorescence, and immunohistochemistry were carried out. The alkaline phosphatase (ALP) activity was measured. Dual-luciferase reporter gene assay and chromatin immunoprecipitation assay were conducted. In OTM models, ZBTB16 was significantly expressed. Additionally, there was an uneven distribution of PDLFs in the OTM group, as well as an increase in fibroblasts and inflammatory infiltration. ZBTB16 interference hindered PDLF osteogenic differentiation and decreased Wnt and β-catenin levels. Meanwhile, ZBTB16 activated the Wnt/β-catenin pathway. ZBTB16 also enhanced the expression of the osteogenic molecules osterix, osteocalcin (OCN), osteopontin (OPN), and bone sialo protein (BSP) at mRNA and protein levels. The interactions between Wnt1 and ZBTB16, as well as GCN5 and ZBTB16, were also verified. The adeno-associated virus-shZBTB16 injection also proved to inhibit osteogenic differentiation and reduce tooth movement distance in in vivo tests. ZBTB16 was up-regulated in OTM. Through acetylation modification of ZBTB16, GCN5 regulated the Wnt/β-catenin signaling pathway and further mediated PDLF osteogenic differentiation.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-02-14T08:00:00Z
      DOI: 10.1139/bcb-2022-0080
       
  • Maternal use of methamphetamine alters cardiovascular function in the
           adult offspring

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      Authors: Adam M. Belcher, Boyd R. Rorabaugh
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Methamphetamine is one of the most commonly used illicit drugs during pregnancy. Most studies investigating the impact of maternal use of methamphetamine on children have focused on neurological outcomes. In contrast, cardiovascular outcomes in these children have not been characterized. Recent studies in rodents provide evidence that prenatal exposure to methamphetamine induces changes in cardiac gene expression, changes in the heart's susceptibility to ischemic injury, and changes in vascular function that may increase the risk of developing cardiovascular disorders later in life. Importantly, these changes are sex-dependent. This review summarizes our current understanding of how methamphetamine use during pregnancy impacts the cardiovascular function of adult offspring and highlights gaps in our knowledge of the potential cardiovascular risks associated with prenatal exposure to methamphetamine.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-02-10T08:00:00Z
      DOI: 10.1139/bcb-2022-0349
       
  • Epidermal melanocytes metabolize extracellular nucleotides by purinergic
           enzymes

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      Authors: Liliana Ivet Sous Naasani, Jéssica Gonçalves Azevedo, Jean Sévigny, Tiago Franco de Oliveira, Silvya Stuchi Maria-Engler, Márcia Rosângela Wink
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      The human epidermal melanocyte (hEM) are melanin-producing cells that provide skin pigmentation and protection against ultraviolet radiation. Although purinergic signaling is involved in skin biology and pathology, the presence of NTPDase members, as well as the rate of nucleotides degradation by melanocytes were not described yet. Therefore, in this study, we analyzed the expression of ectonucleotidases in hEM derived from discarded foreskin of male patients. The expression of purinergic enzymes was confirmed by mRNA and flow cytometry. Among the ectonucleotidases, ectonucleoside triphosphate diphosphohydrolase1 (NTPDase1) and ecto-5´-nucleotidase were the ectoenzymes with higher expressions. The hydrolysis rate for ATP, ADP, and AMP was low in comparison to other primary cells already investigated. The amount of ATP in the culture medium was increased after a scratch wound and decreased to basal levels in 48 h, while the NTPDase1 and P2X7 expressions increased. Therefore, it is possible to suggest that after cell injury, the ATP released by hEM into the extracellular space will be hydrolyzed by ectonucleotidases as the NTPDase1 that will control the levels of nucleotides in the skin micro-environment.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-01-19T08:00:00Z
      DOI: 10.1139/bcb-2022-0058
       
  • RNA deadenylation complexes in development and diseases

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      Authors: Yilin Liu, Niveditha Ramkumar, Ly P. Vu
      First page: 131
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      RNA deadenylation, the process of shortening of the 3′ poly(A) tail of an RNA molecule, is one of the key steps of post-transcriptional regulation of gene expression in eukaryotic cells. PAN2/3 and CCR4-NOT (CNOT) are the two dominant RNA deadenylation complexes, which play central roles in mediating mRNA decay and translation. While degradation is the final fate of virtually all RNAs in their life cycles, selection of RNA targets as well as control of the rate and timing of RNA decay, in coordination with other molecular pathways, including translation, can be modulated in certain contexts. Such regulation influences cell growth, proliferation, and differentiation at the cellular level; and contributes to establish polarity and regulate signaling at the tissue level. Dysregulation of deadenylation processes have also been implicated in human diseases ranging from cardiac diseases and neurodevelopmental disorders to cancers. In this review, we will discuss mechanisms of gene expression control mediated by the RNA deadenylation complexes and highlight relevant evidence supporting the emerging roles of RNA deadenylation and its regulatory proteins during development and in diseases. A systemic understanding of these mechanisms will be a critical foundation for development of effective strategies to therapeutically target them.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-01-16T08:00:00Z
      DOI: 10.1139/bcb-2022-0325
       
  • The nuclear receptor subfamily 4 group A1 in human disease

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      Authors: Hongshuang Wang, Mengjuan Zhang, Fang Fang, Chang Xu, Jiazhi Liu, Lanjun Gao, Chenchen Zhao, Zheng Wang, Yan Zhong, Xiangting Wang
      First page: 148
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Nuclear receptor 4A1 (NR4A1), a member of the NR4A subfamily, acts as a gene regulator in a wide range of signaling pathways and responses to human diseases. Here, we provide a brief overview of the current functions of NR4A1 in human diseases and the factors involved in its function. A deeper understanding of these mechanisms can potentially improve drug development and disease therapy.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-03-02T08:00:00Z
      DOI: 10.1139/bcb-2022-0331
       
  • Emerging roles for heterogeneous ribonuclear proteins in normal and
           malignant B cells

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      Authors: Qurat Ul Ain Qureshi, Timothy E. Audas, Ryan D. Morin, Krysta M. Coyle
      First page: 160
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Heterogeneous nuclear ribonucleoproteins (hnRNPs) are among the most abundantly expressed RNA binding proteins in the cell and play major roles in all facets of RNA metabolism. hnRNPs are increasingly appreciated as essential for mammalian B cell development by regulating the carefully ordered expression of specific genes. Due to this tight regulation of the hnRNP-RNA network, it is no surprise that a growing number of genes encoding hnRNPs have been causally associated with the onset or progression of many cancers, including B cell neoplasms. Here we discuss our current understanding of hnRNP-driven regulation in normal, perturbed, and malignant B cells, and the most recent and emerging therapeutic innovations aimed at targeting the hnRNP–RNA network in lymphoma.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-02-06T08:00:00Z
      DOI: 10.1139/bcb-2022-0332
       
  • Effects of the omega-3 fatty acid DHA on histone and p53 acetylation in
           diffuse large B cell lymphoma

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      Authors: Tanner J. Bakhshi, Tanner Way, Bradley Muncy, Philippe T. Georgel
      First page: 172
      Abstract: Biochemistry and Cell Biology, Ahead of Print.
      Diffuse large B cell lymphoma (DLBCL) often develops resistance and/or relapses in response to immunochemotherapy. Epigenetic modifiers are frequently mutated in DLBCL, i.e., the lysine (histone) acetyltransferases CREBBP and EP300. Mutations in CBP/p300 can prevent the proper acetylation and activation of (i) enhancer sequences of genes required for essential functions (e.g., germinal center exit and differentiation) and (ii) the tumor suppressor p53. Based on evidence that omega-3 fatty acids (ω-3 FAs) affect histone acetylation in various cancers, we investigated whether ω-3 FA docosahexaenoic acid (DHA) could modify levels of histone and p53 acetylation in three DLBCL cell lines (at different CREBBP/EP300 mutational status) versus normal B cells. Exposure to DHA at clinically attainable doses was shown to significantly alter the genome-wide levels of histone posttranslational modifications in a cell-line-dependent and dose-dependent manner. Although histone acetylation did not increase uniformly, as initially expected, levels of p53 acetylation increased consistently. Quantitative reverse transcription polymerase chain reaction results revealed significant changes in expression of multiple genes, including increased expression of CREBBP and of PRDM1 (required for differentiation into plasma cells or memory B cells). Taken together, our results provide (to our knowledge) the first characterization of the epigenetic effects of ω-3 FAs in DLBCL.
      Citation: Biochemistry and Cell Biology
      PubDate: 2023-01-04T08:00:00Z
      DOI: 10.1139/bcb-2022-0288
       
  • Correction: Ultrasound-stimulated microbubbles contributes to radiotherapy
           in esophageal carcinoma

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      Authors: Chenchun Fu, Jinjun Shi, Xiangyu Su, Shicheng Feng, Sheng Wang
      First page: 192
      Abstract: Biochemistry and Cell Biology, Ahead of Print.

      Citation: Biochemistry and Cell Biology
      PubDate: 2023-02-14T08:00:00Z
      DOI: 10.1139/bcb-2022-0305
       
  • Retraction: MiR-154 inhibits the growth of laryngeal squamous cell
           carcinoma by targeting GALNT7

    • Free pre-print version: Loading...

      First page: 197
      Abstract: Biochemistry and Cell Biology, Ahead of Print.

      Citation: Biochemistry and Cell Biology
      PubDate: 2023-03-06T08:00:00Z
      DOI: 10.1139/bcb-2023-0037
       
 
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