Subjects -> SOCIAL SCIENCES (Total: 1648 journals)
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    - MEN'S STUDIES (90 journals)
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    - SOCIAL SCIENCES (937 journals)
    - WOMEN'S INTERESTS (44 journals)
    - WOMEN'S STUDIES (175 journals)

WOMEN'S STUDIES (175 journals)                     

Showing 1 - 146 of 146 Journals sorted by number of followers
Women & Criminal Justice     Hybrid Journal   (Followers: 313)
Gender & Society     Hybrid Journal   (Followers: 101)
Urban Studies     Hybrid Journal   (Followers: 81)
Gender & Development     Hybrid Journal   (Followers: 74)
Gender, Work & Organization     Hybrid Journal   (Followers: 68)
Signs: Journal of Women in Culture and Society     Full-text available via subscription   (Followers: 58)
Political Studies     Hybrid Journal   (Followers: 46)
Gender, Place & Culture: A Journal of Feminist Geography     Hybrid Journal   (Followers: 45)
Journal of Gender Studies     Hybrid Journal   (Followers: 43)
Violence Against Women     Hybrid Journal   (Followers: 39)
Gender Studies     Open Access   (Followers: 38)
Hypatia : A Journal of Feminist Philosophy     Hybrid Journal   (Followers: 33)
Journal of Feminist, Gender and Women Studies     Open Access   (Followers: 32)
Feminist Media Studies     Hybrid Journal   (Followers: 28)
Gender & History     Hybrid Journal   (Followers: 27)
Feminist Studies     Full-text available via subscription   (Followers: 27)
Feminist Theory     Hybrid Journal   (Followers: 26)
Feminist Legal Studies     Hybrid Journal   (Followers: 25)
Communication Papers : Media Literacy & Gender Studies     Open Access   (Followers: 25)
Gender and Education     Hybrid Journal   (Followers: 24)
Feminist Review     Hybrid Journal   (Followers: 24)
Gender Issues     Hybrid Journal   (Followers: 23)
Journal of Women's History     Full-text available via subscription   (Followers: 23)
Journal of Gender, Social Policy & the Law     Open Access   (Followers: 23)
Political Studies Review     Hybrid Journal   (Followers: 22)
Black Women, Gender & Families     Full-text available via subscription   (Followers: 22)
International Feminist Journal of Politics     Hybrid Journal   (Followers: 21)
Social Politics: International Studies in Gender, State & Society     Hybrid Journal   (Followers: 21)
Studies in Gender and Sexuality     Hybrid Journal   (Followers: 21)
Feminist Criminology     Hybrid Journal   (Followers: 20)
Feminism & Psychology     Hybrid Journal   (Followers: 19)
Gender and Language     Hybrid Journal   (Followers: 19)
Journal of Middle East Women's Studies     Full-text available via subscription   (Followers: 19)
Early Modern Women : An Interdisciplinary Journal     Full-text available via subscription   (Followers: 18)
European Journal of Women's Studies     Hybrid Journal   (Followers: 17)
Assuming Gender     Open Access   (Followers: 17)
Contemporary Women's Writing     Hybrid Journal   (Followers: 16)
Psychology & Sexuality     Hybrid Journal   (Followers: 16)
Australian Feminist Studies     Hybrid Journal   (Followers: 15)
Gender, Technology and Development     Hybrid Journal   (Followers: 15)
Women's History Review     Hybrid Journal   (Followers: 15)
Women and Music: A Journal of Gender and Culture     Full-text available via subscription   (Followers: 15)
WSQ: Women's Studies Quarterly     Full-text available via subscription   (Followers: 15)
Australian Feminist Law Journal     Hybrid Journal   (Followers: 15)
Religion and Gender     Open Access   (Followers: 15)
Women Against Violence : An Australian Feminist Journal     Full-text available via subscription   (Followers: 13)
Atlantis : Critical Studies in Gender, Culture & Social Justice     Open Access   (Followers: 13)
Journal of Women Politics & Policy     Hybrid Journal   (Followers: 12)
Advances in Gender Research     Full-text available via subscription   (Followers: 12)
Nashim : A Journal of Jewish Women's Studies & Gender Issues     Full-text available via subscription   (Followers: 11)
Journal of Family Studies     Hybrid Journal   (Followers: 11)
Indian Journal of Gender Studies     Hybrid Journal   (Followers: 10)
Journal of Feminist Studies in Religion     Full-text available via subscription   (Followers: 10)
Psychology of Women Quarterly     Hybrid Journal   (Followers: 10)
Gender and Behaviour     Open Access   (Followers: 9)
International Journal of Gender Studies in Developing Societies     Hybrid Journal   (Followers: 9)
Clio. Women, Gender, History     Open Access   (Followers: 9)
Feminist Anthropology     Open Access   (Followers: 9)
Women's Studies International Forum     Hybrid Journal   (Followers: 8)
Tulsa Studies in Women's Literature     Full-text available via subscription   (Followers: 8)
Affilia     Hybrid Journal   (Followers: 7)
Feminist Theology     Hybrid Journal   (Followers: 7)
Women's Studies : An inter-disciplinary journal     Hybrid Journal   (Followers: 7)
Frontiers : A Journal of Women Studies     Full-text available via subscription   (Followers: 7)
Feminist Formations     Full-text available via subscription   (Followers: 7)
Feminist German Studies     Full-text available via subscription   (Followers: 7)
The Women : Annual Research Journal of Gender Studies     Open Access   (Followers: 7)
Genre, sexualité & société     Open Access   (Followers: 6)
Girlhood Studies     Full-text available via subscription   (Followers: 6)
Lilith: A Feminist History Journal     Full-text available via subscription   (Followers: 6)
Journal of Interdisciplinary Feminist Thought     Open Access   (Followers: 6)
History of Women in the Americas     Open Access   (Followers: 6)
Women, Gender, and Families of Color     Full-text available via subscription   (Followers: 6)
Women in Higher Education     Hybrid Journal   (Followers: 6)
Feminist Philosophy Quarterly     Open Access   (Followers: 6)
Journal of Lesbian Studies     Hybrid Journal   (Followers: 5)
Meridians : feminism, race, transnationalism     Full-text available via subscription   (Followers: 5)
Women's Writing     Hybrid Journal   (Followers: 5)
International Journal of Gender and Entrepreneurship     Hybrid Journal   (Followers: 5)
Women's Studies in Communication     Hybrid Journal   (Followers: 5)
Women in Judaism : A Multidisciplinary e-Journal     Open Access   (Followers: 5)
GÉNEROS - Multidisciplinary Journal of Gender Studies     Open Access   (Followers: 5)
Journal of Women and Gender in Higher Education     Hybrid Journal   (Followers: 5)
Journal of Women & Aging     Hybrid Journal   (Followers: 4)
Nora, Nordic Journal of Women's Studies     Hybrid Journal   (Followers: 4)
Women: A Cultural Review     Hybrid Journal   (Followers: 4)
Legacy : A Journal of American Women Writers     Full-text available via subscription   (Followers: 4)
Canadian Journal of Women and the Law     Full-text available via subscription   (Followers: 4)
Canadian Woman Studies     Full-text available via subscription   (Followers: 4)
Journal of International Women's Studies     Open Access   (Followers: 4)
Case Reports in Women's Health     Open Access   (Followers: 4)
Michigan Journal of Gender and Law     Free   (Followers: 4)
Columbia Journal of Gender and Law     Open Access   (Followers: 4)
Journal of Feminist Family Therapy     Hybrid Journal   (Followers: 3)
Women & Therapy     Hybrid Journal   (Followers: 3)
ninepatch : A Creative Journal for Women and Gender Studies     Open Access   (Followers: 3)
UCLA Women's Law Journal     Open Access   (Followers: 3)
ABO : Interactive Journal for Women in the Arts, 1640-1830     Open Access   (Followers: 3)
Feminist Modernist Studies     Hybrid Journal   (Followers: 3)
Whatever : A Transdisciplinary Journal of Queer Theories and Studies     Open Access   (Followers: 3)
Journal of the European Society of Women in Theological Research     Full-text available via subscription   (Followers: 2)
NAN Nü     Hybrid Journal   (Followers: 2)
International Journal of Feminist Approaches to Bioethics     Full-text available via subscription   (Followers: 2)
Feminist Teacher     Full-text available via subscription   (Followers: 2)
Recherches féministes     Full-text available via subscription   (Followers: 2)
NASPA Journal About Women in Higher Education     Hybrid Journal   (Followers: 2)
William & Mary Journal of Women and the Law     Open Access   (Followers: 2)
Journal of Women's Entrepreneurship and Education (JWEE)     Open Access   (Followers: 2)
Cadernos Pagu     Open Access   (Followers: 1)
Revista Estudos Feministas     Open Access   (Followers: 1)
Les cahiers du CEDREF     Open Access   (Followers: 1)
Journal of Ayn Rand Studies     Full-text available via subscription   (Followers: 1)
Palimpsest : A Journal on Women, Gender, and the Black International     Full-text available via subscription   (Followers: 1)
PALASTReN : Jurnal Studi Gender     Open Access   (Followers: 1)
Cadernos de Gênero e Diversidade     Open Access   (Followers: 1)
La Manzana de la Discordia     Open Access   (Followers: 1)
Open Gender Journal     Open Access   (Followers: 1)
Sexuality, Gender & Policy     Hybrid Journal   (Followers: 1)
Ambigua : Revista de Investigaciones sobre Género y Estudios Culturales     Open Access   (Followers: 1)
Queer Cats Journal of LGBTQ Studies     Open Access   (Followers: 1)
Sextant : Revue de recherche interdisciplinaire sur le genre et la sexualité     Open Access  
Simone de Beauvoir Studies     Full-text available via subscription  
Kvinder, Køn & Forskning / Women, Gender & Research     Open Access  
DUODA : estudis de la diferència sexual     Open Access  
iQual : Revista de Género e Igualdad     Open Access  
Tidsskrift for kjønnsforskning     Open Access  
Journal of Obstetrics and Women's Diseases     Open Access  
Musas : Revista de Investigación en Mujer, Salud y Sociedad     Open Access  
Akdeniz Kadın Çalışmaları ve Toplumsal Cinsiyet Dergisi / Mediterranean Journal of Gender and Women’s Studies     Open Access  
Nomadías     Open Access  
Sawwa : Jurnal Studi Gender     Open Access  
Cuestiones de género: de la igualdad y la diferencia     Open Access  
Antyajaa : Indian Journal of Women and Social Change     Hybrid Journal  
Lectora : Revista de Dones i Textualitat     Open Access  
Tijdschrift voor Genderstudies     Full-text available via subscription  
EGALITA     Open Access  
Revista Feminismos     Open Access  
querelles-net : Rezensionszeitschrift für Frauen- und Geschlechterforschung     Open Access  
Investigaciones Feministas     Open Access  
Agenda     Partially Free  
La Aljaba     Open Access  
Storia delle Donne     Open Access  
Mora (Buenos Aires)     Open Access  
International Journal of Impotence Research     Hybrid Journal  
Hawwa     Hybrid Journal  
Aspasia     Full-text available via subscription  

           

Similar Journals
Journal Cover
Journal of Obstetrics and Women's Diseases
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1684-0461 - ISSN (Online) 1683-9366
Published by Eco-Vector LLC Homepage  [15 journals]
  • IGF1R rs907806 and GHSR rs572169 genetic variants in fetal
           macrosomia

    • Authors: Elena N. Alekseenkova, Ziravard N. Tonyan, Yulia A. Nasykhova, Ekaterina V. Kopteeva, Roman V. Kapustin, Igor Yu. Kogan
      Pages: 7 - 18
      Abstract: BACKGROUND: Being strongly affected by maternal and fetal genetic factors, intrauterine environment plays a critical role in fetal growth. Intrauterine conditions, in turn, are largely determined by the genetic factors. AIM: The aim of this study was to evaluate the effect of the IGF1R rs907806 and GHSR rs572169 genetic variants on the weight of newborns. MATERIALS AND METHODS: This prospective study included 221 mother-newborn pairs. The inclusion criteria were singleton pregnancy and informed consent to participate in the study. The exclusion criteria were severe somatic, oncological and acute illnesses three months prior or during pregnancy, gestational diabetes mellitus, refusal to participate in the study at any stage, and insufficient data. The study groups included patients with type 1 diabetes mellitus (group I), type 2 diabetes mellitus (group II), and no carbohydrate metabolism disorders (group III). Cord blood samples were obtained after delivery. The IGF1R rs907806 and GHSR rs572169 genotypes were determined by polymerase chain reaction with restriction fragment length polymorphism analysis. The main outcomes were delivery of a large for gestational age fetus (weight of more than the 90th percentile INTERGROWTH-21st). The secondary outcomes were diabetic fetopathy, diabetic cardiomyopathy, and neonatal hypoglycemia. RESULTS: In group III, the minor G allele of the IGF1R rs907806 variant was more frequent in large-for-gestational-age newborns (p = 0.017; odds ratio 3.039; 95% confidence interval 1.244–7.424) than in those with a weight of less than 90th percentile. For the GHSR rs572169 variant, no similar trend was observed. This pattern was pronounced in the male newborns only (rs907806 AA vs. AG+GG; p = 0.046; odds ratio 4.229, 95% confidence interval 1.181–15.139). In newborns with hypoglycemia, a higher frequency of the GG genotype of the GHSR rs572169 (G>A) variant was observed in the total sample (p = 0.004) and the type 1 diabetes mellitus group (p = 0.0496). CONCLUSIONS: The IGF1R rs907806 variant may affect birthweight in the male newborns of mothers without carbohydrate metabolism disorders. The observed association of neonatal hypoglycemia with the GG genotype of the GHSR rs572169 variant requires further investigation. Genetic factors can contribute to prognostic models of perinatal complications, while improving their early diagnosis opportunities.
      PubDate: 2024-07-17
      DOI: 10.17816/JOWD625728
      Issue No: Vol. 73, No. 3 (2024)
       
  • ABC of the future: prolonged coculture of human embryos with endometrium
           in a nutrient medium in vitro

    • Authors: Olesya N. Bespalova, Evgenia M. Komarova, Elena A. Lesik, Ksenia V. Ob’edkova, Natalia I. Tapilskaya, Igor Yu. Kogan
      Pages: 19 - 25
      Abstract: BACKGROUND: The development of new systems for the cultivation of embryos of model objects and the creation of embryonic models based on stem cells allow for describing the events of early embryogenesis in more detail. However, these models have a number of limitations, endorsing only indirect extrapolation of the knowledge gained to events occurring in vivo. Despite certain limitations, including those related to some differences between embryos developing in vivo and in vitro, implantation conditions in vivo and in vitro, and limited time for culturing human embryos, the study of post-implantation development has great prospects. AIM: The aim of this study was to evaluate the viability and potential for the development of human embryos from the blastocyst stage during their prolonged coculture with the endometrium in culture media designed to support the growth to the blastocyst stage. MATERIALS AND METHODS: Embryos obtained through assisted reproductive technology were cultured from the blastocyst stage to day 19st of development in culture media designed to support the growth to the blastocyst stage, in the presence of the endometrium. On day 19st, embryos and endometrial fragments were assessed under an inverted microscope using Hoffman modulation contrast. RESULTS: During visual assessment under an inverted microscope on day 19st of development and days 13–14st of coculture with the endometrium, viable developing embryos without signs of degradation were recorded, both freely located in a mass of undifferentiated cells and in direct contact with the endometrium. CONCLUSIONS: The data obtained indicate the ability of the embryo to further develop in the presence of the endometrium from the blastocyst stage to day 19st in in culture media that supports the growth to the blastocyst stage. This may serve as an experimental model for both evaluating endometrial receptivity in vitro and studying intercellular communication during implantation.
      PubDate: 2024-07-17
      DOI: 10.17816/JOWD629131
      Issue No: Vol. 73, No. 3 (2024)
       
  • Antagonistic and antibacterial activity of Lactobacillus rhamnosus HN001
           and Lactobacillus acidophilus La-14 included in the oral probiotic

    • Authors: Olga V. Budilovskaya, Elena V. Spasibova, Kira V. Shalepo, Tatiana A. Khusnutdinova, Anna A. Krysanova, Anna A. Siniakova, Olesya N. Bespalova, Alevtina M. Savicheva
      Pages: 27 - 39
      Abstract: BACKGROUND: A microbial imbalance in the vaginal biotope leads to the development of vaginal infections and is associated with urinary tract infections. The ineffectiveness of the therapy and the frequent recurrence of these infections are important reasons for searching for alternative treatment strategies. A progressive solution to this issue has been the use of oral probiotics with a targeted effect on the intestinal and vaginal microflora. AIM: The aim of this study was to evaluate the antagonistic and antibacterial activity of the probiotic strains Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus La-14, which are the components of the oral probiotic, against opportunistic microorganisms of intestinal origin, while assessing the sensitivity of these strains to antimicrobial drugs. MATERIALS AND METHODS: The probiotic strains Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus La-14 included in the oral probiotic Duogynal® were cultivated and the grown colonies were identified using the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry method (Bruker Daltonics GmbH & Co., Germany). To study the antagonism of the probiotic strains of lactobacilli and opportunistic pathogenic microorganisms, the following 11 clinical isolates were collected: Escherichia coli (two isolates), Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter asburiae, Proteus mirabilis, Citrobacter freundii, Staphylococcus aureus, Enterococcus faecalis, Streptococcus agalactiae, and Candida albicans. To assess the sensitivity of the probiotic strains to antimicrobial drugs, the Gram Positive AST panel (Autobio Diagnostics Co., Ltd, China) was used. RESULTS: When the microorganisms were co-cultivated with the probiotic lactobacilli (Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus La-14), we noted a decrease in pH and the death of opportunistic microorganisms such as Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter asburiae, Proteus mirabilis, Citrobacter freundii, Staphylococcus aureus, Enterococcus faecalis, and Streptococcus agalactiae, as well as yeast-like fungi Candida albicans. When studying antibiotic resistance, it was found that the both strains of lactobacilli were resistant to ampicillin, vancomycin, daptomycin, clindamycin, linezolid, moxifloxacin, nitrofurantoin, oxacillin, oritavancin, penicillin, rifampin, teicoplanin, tigecycline, trimethoprim/sulfamethoxazole, cefoxitin, ceftarolin, and ciprofloxacin. CONCLUSIONS: The oral probiotic, which contains a combination of two lactobacilli (Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus La-14), has pronounced antagonistic activity against opportunistic microorganisms. These strains are resistant to most antibacterial drugs used in widespread clinical practice, which may be the basis for recommending the use of this probiotic drug together with prescribed antibiotics for prevention of vaginal or intestinal dysbiosis.
      PubDate: 2024-07-17
      DOI: 10.17816/JOWD630698
      Issue No: Vol. 73, No. 3 (2024)
       
  • The spectrum of infections identified in pregnant women with different
           types of fetal growth restriction

    • Authors: Natalya G. Istomina, Elizaveta A. Shcherbakova, Alexey N. Baranov, Tatyana B. Lebedeva
      Pages: 41 - 52
      Abstract: BACKGROUND: Bacterial, viral and protozoal infections can cause miscarriage, antenatal death, congenital organ abnormalities or other limited consequences depending on the pathogen. The role of infection processes identified during pregnancy on placental pathology and fetal growth restriction. AIM: The aim of this study was to conduct a comparative analysis of infections identified in pregnant women with different types of fetal growth restriction, as well as to assess a potential impact of identified infections on the outcomes of fetal growth restriction in newborns in the same groups. MATERIALS AND METHODS: We performed a retrospective analysis of outcomes for 394 pregnant women with an established diagnosis of fetal growth restriction, who had given birth from 2018 to 2022 in the Perinatal Center of the Arkhangelsk Regional Clinical Hospital. Maternal and neonatal case histories were obtained using a continuous sampling method. Considering the transition to new criteria for establishing the diagnosis of fetal growth restriction in Russia, we formed four study groups, of which only 139 cases met the Delphi criteria of clinical guidelines by Russian Society of Obstetricians and Gynecologists, 2021. In the selected groups, we analyzed the results of microscopic and microbiological tests of various localizations in mothers during antepartum examination, as well as postpartum examination of the placenta and culture tests in newborns in their relation to adverse outcomes. RESULTS: A high prevalence (25–70.4%) of positive bacteriological findings was revealed in all of the study groups. The frequency was highest in the group of pregnant women with fetal growth restriction before 32 weeks (90–92%). Combined infections (two or more localizations) were noted in 59.2% of pregnant women in groups with early fetal growth restriction compared to 23.3% in late fetal growth restriction groups. In all cases, we observed a direct relationship between the severity of fetal growth restriction and the prevalence of infections. The range of infections identified during routine examination of pregnant women is quite limited; Candida spp. (from 40.8% in the control group to 75% in the comparison group), Escherichia coli (from 22.9 to 33.3%, respectively), and Chlamydia trachomatis (from 4.5 to 23.5%, respectively) being identified most commonly. In a morphological study of the placenta, infectious and inflammatory lesions were the most significant and ranged from 100 to 81.4% of cases in groups with early and late fetal growth restriction, respectively, with signs of hematogenous transmission prevailed. When analyzing infectious lesions in fetuses, we have found the presence of three and more localizations of the infectious process in 90 to 45% of cases with a fatal outcome for early and late fetal growth restriction, respectively. In the control groups, similar rates were 40 and 15.8%. When assessing the distribution of various types of infectious process in newborns, Candida spp., Escherichia coli, and Enterococcus faecalis also took the lead in all cases. However, the percentage of the same etiology of maternal and neonatal infections turned out to be very low (from 0 to 31% for individual pathogens), which makes it difficult to apply preventive treatment during pregnancy. CONCLUSIONS:
      Authors identified indirect but numerous signs of significant involvement of infectious processes in the development of fetal growth restriction, especially its early type, as well as the influence of infections on the outcomes for such newborns. In most cases, infectious processes during pregnancy are subclinical. Current screening of pregnant women is insufficient to identify high-risk groups. Examination of pregnant women for infections carried out by culture tests provide low-component and, most likely, incomplete information.
      PubDate: 2024-07-17
      DOI: 10.17816/JOWD626378
      Issue No: Vol. 73, No. 3 (2024)
       
  • The role of cervicovaginal microbiota in the occurrence of severe cervical
           intraepithelial dysplasia

    • Authors: Anna V. Kazakova, Svetlana M. Chechko, Evgeny F. Kira
      Pages: 53 - 60
      Abstract: BACKGROUND: Despite the availability of visual examination of the cervix, cervical screening in Russia has not been widespread enough, and therefore the incidence of cervical cancer remains consistently high. In recent years, the vaginal microbiota is given special attention as a risk factor for the development of precancerous diseases of the cervix. AIM: The aim of this study was to compare the cervicovaginal microbiota in patients with high-grade squamous intraepithelial lesions (HSIL) or negative for intraepithelial lesions or malignancy (NILM). MATERIALS AND METHODS: Microorganisms isolated from the cervicovaginal microbiota were identified in 40 patients using the mass spectrometry method. 20 women had severe cervical dysplasia, and the other 20 were healthy women without precancerous cervical lesions. RESULTS: Corynebacterium spp. and Streptococcus spp. were found more often in the cervicovaginal microbiome in patients with high-grade squamous intraepithelial lesions than in women negative for intraepithelial lesions or malignancy. CONCLUSIONS: The data obtained suggest that the presence of Corynebacterium spp. and Streptococcus spp. in the cervicovaginal microbiota is associated with the presence of severe cervical intraepithelial changes.
      PubDate: 2024-07-17
      DOI: 10.17816/JOWD624931
      Issue No: Vol. 73, No. 3 (2024)
       
  • Evaluation of the effectiveness of innovative methods of focused
           ultrasound and uterine artery embolization in the treatment of uterine
           fibroids

    • Authors: Lyudmila V. Kaushanskaya, Zareta M. Gatagazheva, Zukhra K. Uzdenova, Malika M. Gatagazheva, Khava A. Arsanukaeva, Nesredin A. Makhmudov, Darya P. Minigulova
      Pages: 61 - 68
      Abstract: BACKGROUND: Uterine fibroids are one of the most common gynecological diseases. The application of innovative techniques such as focused ultrasound ablation and uterine artery embolization has improved the quality of life of many patients. However, despite significant advances in innovative therapies, there is no certainty about the long-term efficacy of focused ultrasound ablation and uterine artery embolization. AIM: The aim of this study was to compare the efficacy of focused ultrasound ablation and uterine artery embolization treatments of uterine fibroids. MATERIALS AND METHODS: This study analyzed observations of 112 patients with uterine fibroids. Patients in the first group were treated with focused ultrasound ablation (n = 44). The second group of patients underwent uterine artery embolization (n = 68). RESULTS: The study groups differed in the reduction of myomatous node sizes one, three, six and 12 months after surgery, depending on the chosen treatment method (p < 0.001). In the first group, fibroid volume decreased by 14% after a month and by 35% after 12 months. In the second group, it decreased by 20% after a month and by 54% after a year. CONCLUSIONS: Treatment with the uterine artery embolization method reduced fibroid volume by 54%, which is 19% more effective than the focused ultrasound ablation method.
      PubDate: 2024-07-17
      DOI: 10.17816/JOWD629136
      Issue No: Vol. 73, No. 3 (2024)
       
  • Assessment of endometrial and subendometrial three-dimensional power
           Doppler angiography evaluated by the VOCAL method in frozen-thawed embryo
           transfer cycles on hormone replacement therapy

    • Authors: Galina Kh. Safarian, Ksenia V. Ob'edkova, Julian R. Ryzhov, Inna O. Krikheli, Lyailya Kh. Dzhemlikhanova, Manizha R. Makhmadalieva, Maria S. Mazurenko, Natalia I. Tapilskaya, Alexander M. Gzgzyan, Olesya N. Bespalova
      Pages: 69 - 80
      Abstract: BACKGROUND: The effectiveness of in vitro fertilization cycles / frozen-thawed embryo transfer cycles depends on a number of factors, the endometrial one being of great importance. Adequate endometrial and subendometrial blood supply is considered necessary for successful implantation. Currently, the possibilities of non-invasive assessment of the implantation properties of the endometrium are limited to the use of ultrasound. AIM: The aim of this study was to assess the performance of endometrial and subendometrial three-dimensional power Doppler angiography combined with the Virtual Organ Computer-aided Analysis (VOCAL) method in frozen-thawed embryo transfer cycles on hormone replacement therapy and compare the obtained data among the women examined. MATERIALS AND METHODS: This prospective study included 20 women. Doppler measurements were carried out three times — on the day of progesterone initiation, the day before embryo transfer and on the day of embryo transfer. The VOCAL software assessed the endometrial and subendometrial volume and blood flow indices such as vascularization index, flow index, and vascularization flow index. Patients were divided into two study groups depending on the onset of clinical pregnancy. RESULTS: On the day of progesterone initiation among patients who got pregnant, we observed higher vascularization (3.52 ± 1.99 vs. 1.05 ± 1.36; p = 0.03) and vascularization flow (1.54 ± 0.98 vs. 0.63 ± 0.55; p = 0.03) indices compared to women with a negative result. Moreover, endometrial vascularization index on the day of progesterone initiation was positively correlated with the estrogen dose among both pregnant (r = 0.61; p = 0.04) and non-pregnant (r = 0.9; p = 0.0008) women. No differences in subendometrial blood flow indices depending on the onset of pregnancy were obtained, just as endometrial blood flow indices the day before embryo transfer and on the day of embryo transfer were comparable between women in the both study groups. CONCLUSIONS: Three-dimensional power Doppler angiography evaluated by the Virtual Organ Computer-aided Analysis (VOCAL) method is a promising tool for non-invasive assessment of endometrial receptivity in frozen-thawed embryo transfer programs. However, further studies are required on a larger patient sample to form conclusions that are more accurate.
      PubDate: 2024-07-17
      DOI: 10.17816/JOWD627896
      Issue No: Vol. 73, No. 3 (2024)
       
  • Role of vimentin in the morphogenesis of endometrial decidualization
           during pregnancy with IVF methods

    • Authors: Tatiana G. Tral, Gulrukhsor Kh. Tolibova
      Pages: 81 - 88
      Abstract: BACKGROUND: Early reproductive loss is a complex problem, the solution of which requires a systematic approach to the study of the morphogenesis of gravid transformation. Violations of the morphofunctional characteristics of the endometrium are associated with chronic endometritis, which entails implantation pathology and the development of pregnancy, while formulating indications for the use of IVF methods. Chronic endometritis disrupts the differentiation of stromal cells and intermediate filaments with subsequent pathology of decidualization and gravid transformation. AIM: The aim of this study was to evaluate vimentin expression in decidual cells of the gravid endometrium in an undeveloped first-trimester pregnancy after IVF, depending on its transformation in patients with chronic endometritis. MATERIALS AND METHODS: Histological and immunohistochemical studies were performed on 40 samples of abortion material with normal chorionic villi karyotype from a non-developing pregnancy after IVF in patients with chronic endometritis and 15 samples of abortion material from a progressive pregnancy, surgically terminated at the woman’s request at similar terms. Two groups were formed — I group with a full-fledged gravid transformation in a non-developing pregnancy after IVF (n = 20) and II group with an incomplete gravid transformation in a non-developing pregnancy after IVF (n = 20). Histological examination was performed according to the standard procedure. Immunohistochemical study was performed using a one-step protocol with antigen unmasking. Primary monoclonal antibodies to vimentin (Clon V9, Diagnostic BioSystems Inc., Spain) were used at a 1 : 1000 dilution. Vimentin expression was evaluated in the compact layer of the gravid endometrium. RESULTS: A full-fledged gravid transformation of the endometrial stroma in the abortion material in study group I and the control group was represented by mature deciduocytes of the epithelioid type, round or polygonal in shape, with a light vesicular nucleus. With an incomplete gravid transformation, the compact layer of the gravid endometrium was represented by fibroblasts with varying degrees of cytoplasmic development, from mild changes to the formation of pre-decidual and immature decidual cells. A decrease in vimentin expression was verified in the gravid endometrium after IVF compared to the control group. In case of an incomplete gravid transformation, a decrease in vimentin expression was also verified compared to the control group and study group I. CONCLUSIONS: The presence of chronic endometritis in patients with infertility and chronic endometritis not only causes pathology of the original endometrium, but also disrupts decidualization, leading to reproductive loss with normal embryo karyotype.
      PubDate: 2024-07-17
      DOI: 10.17816/JOWD630372
      Issue No: Vol. 73, No. 3 (2024)
       
  • The role of umbilical-portal venous hemodynamics in fetal macrosomia
           pathogenesis in pregnancy complicated by diabetes mellitus

    • Authors: Elizaveta V. Shelaeva, Ekaterina V. Kopteeva, Elena N. Alekseenkova, Roman V. Kapustin, Igor Yu. Kogan
      Pages: 89 - 104
      Abstract: BACKGROUND: During pregnancy complicated by diabetes mellitus, the risks of developing fetal macrosomia and other perinatal complications increase. Redistribution of blood flow in the fetal umbilical-portal venous system may be an important but poorly understood compensatory mechanism that affects macrosomic fetal growth. AIM: The aim of this study was to determine the features of the fetal umbilical-portal venous hemodynamics in pregnant women with various types of diabetes mellitus and the absence of carbohydrate metabolism disorders, taking into account the gestational age and the macrosomic fetal growth. MATERIALS AND METHODS: In this prospective cohort study, 86 pregnant women with pregestational diabetes mellitus, 44 pregnant women with gestational diabetes mellitus and 58 patients without carbohydrate metabolism disorders underwent ultrasound examinations from 30+0 to 41+3 weeks of gestation. During ultrasound, we performed Doppler assessment of venous hemodynamic parameters in the vessels of the umbilical-portal venous system, with volumetric blood flow calculated for each vessel. Additionally, the total liver volumetric blood flow and ductus venosus shunt fraction were calculated. RESULTS: The presence of fetal macrosomia in patients from the pregestational diabetes mellitus group is associated with an increase in the volumetric blood flow of the umbilical vein by 89.5 ml/min (p = 0.003) and the left portal vein by 33.3 ml/min (p = 0.008), as well as the total volumetric blood flow of the fetal liver by 95.7 ml/min (p = 0.001) compared with normal-weight fetuses. At the same time, the ductus venosus shunt fraction decreased in macrosomic fetuses by 3.83% (p = 0.001). In the gestational diabetes mellitus and control groups, despite the tendency for these parameters to increase in fetuses with macrosomia, the differences did not reach statistical significance. With a left portal vein volume flow threshold of 94.51 ml/min, the sensitivity and specificity for predicting large births were 84.46 and 72.09%, respectively. CONCLUSIONS: Pregestational diabetes mellitus in the mother is associated with a priority redistribution of blood flow to the fetal liver and is accompanied by a decrease in the ductus venosus shunt fraction. The severity of these hemodynamic changes increases in the presence of fetal macrosomia, which confirms the role of liver perfusion in the regulation of fetal growth in uncomplicated pregnancy and maternal diabetes mellitus.
      PubDate: 2024-07-17
      DOI: 10.17816/JOWD629597
      Issue No: Vol. 73, No. 3 (2024)
       
  • Changes in cerebral hemodynamics after week 32 of gestation in fetuses
           with late-onset fetal growth restriction

    • Authors: Sofia R. Yusenko, Stanislava V. Nagorneva, Igor Yu. Kogan
      Pages: 105 - 114
      Abstract: BACKGROUND: Late-onset fetal growth restriction is characterized by changes in fetal cerebral hemodynamic patterns. Blood flow parameters in the anterior, middle, and posterior cerebral arteries have been studied previously, and there was shown a relationship between changes in certain cerebral artery vascular resistance parameters and increased risk of adverse perinatal outcomes such as fetal hypoxia in labor, cesarean section, and stillbirth. AIM: The aim of this study was to search for cerebral hemodynamic patterns in fetuses with late-onset fetal growth restriction after week 32 of gestation. MATERIALS AND METHODS: This prospective study included 110 pregnant women at week 32 or more of gestation who underwent fetal ultrasound (fetometry and Doppler with additional measurement of vascular resistance parameters in the anterior and posterior cerebral arteries). Ultrasound findings were assessed for the presence of late-onset fetal growth restriction. The systole-diastolic ratio, resistance index, and pulsatility index were evaluated in appropriate-for-gestational-age fetuses and in fetuses with late-onset fetal growth restriction. RESULTS: A total of 128 middle, 86 anterior, and 87 posterior cerebral arteries measurements were included in the calculations. From weeks 32–33 to preterm gestation in appropriate-for-gestational-age fetuses, a decrease in the middle cerebral artery parameters was observed, while in the anterior and posterior cerebral arteries, the vascular resistance parameters remained at the same level or slightly increased. A nonlinear trend of blood flow changes in the anterior and posterior cerebral arteries was observed in fetuses with fetal growth restriction — the values increased by weeks 34–36 of gestation and decreased in preterm gestation. At the same time, differences (р < 0.05) were found between the median values of the systolic-diastolic ratio, resistance index and pulsatility index in the anterior and posterior cerebral arteries at weeks 34–36 and those at preterm gestation. CONCLUSIONS: Changes in fetal cerebral hemodynamics in fetal growth restriction, in particular, a shift in the peak values of vascular resistance parameters to later gestational periods may be associated with changes in the development of integrative functions of the central nervous system and neurovascular development of the fetal brain (cortex), which occurs predominantly in the third trimester of pregnancy.
      PubDate: 2024-07-17
      DOI: 10.17816/JOWD629299
      Issue No: Vol. 73, No. 3 (2024)
       
  • A modern view of pregnancy management tactics with a tendency to post-term
           pregnancy

    • Authors: Ainura M. Burkitova, Gulnura M. Burkitova, Vyacheslav M. Bolotskikh
      Pages: 115 - 123
      Abstract: This analytical review article compares elective induction of labor with expectant management for a tendency to post-term pregnancy and examines its impact on maternal and neonatal outcomes and caesarean section rates. Currently, the issue of management tactics during pregnancy beyond 41 weeks remains hotly debated and requires further research.
      PubDate: 2024-07-17
      DOI: 10.17816/JOWD630054
      Issue No: Vol. 73, No. 3 (2024)
       
  • Peculiarities of anesthesia for caesarean section in patients with
           gestational diabetes mellitus

    • Authors: Oksana V. Ryazanova, Valerii I. Shadenkov, Roman V. Kapustin, Igor Yu. Kogan
      Pages: 125 - 132
      Abstract: BACKGROUND: Women with gestational diabetes mellitus are at high risk of operative delivery. Meanwhile, hyperglycemia affects the metabolism of narcotic analgesics, while increasing their need. Thus, the anesthesiologist is faced with the question of what method of anesthesia to choose for a particular cesarean section. AIM: The aim of this study was to estimate the features of the perioperative period of cesarean section in patients with gestational diabetes mellitus. MATERIALS AND METHODS: This prospective, controlled, single-center study enrolled 101 patients who were delivered by planned cesarean sections from April to November 2023. Group 1 included patients with gestational diabetes mellitus on diet therapy (n = 28), group 2 comprised patients with gestational diabetes mellitus on insulin therapy (n = 29), and group 3 (control) included women with a normal pregnancy without carbohydrate metabolism disturbances (n = 44). RESULTS: The highest initial values of mean arterial pressure were in group 2 and amounted to 91.8 ± 7.0 mmHg. In group 1, the mean arterial pressure was within 89.1 ± 6.4 mmHg, and in group 3, that was 85.9 ± 9.1 mmHg, which was significant (p < 0.05). The sympathetic block developed longer in patients of group 2. In group 1, the sensory block was recorded at the ThIV–ThV level after 10.1 minutes and the motor block (Bromage score 3) after 12.2 minutes compared to 7.8 and 8.6 minutes, respectively, in group 2, and 4.5 and 5.1 minutes, respectively, in group 3. In group 2, authors observed the most rapid regression of the block (79.4 minutes after the injection of local anesthetic), which required an earlier start of the transversus abdominis plane block (after 65.3 minutes). The sympathetic block regressed after 86.2 and 138.1 minutes in patients of groups 1 and 3, respectively (p < 0.05), when the transversus abdominis plane block was performed. Thus, immediately after cesarean section, women with gestational diabetes mellitus (especially on insulin therapy) had a higher need for analgesics than those without gestational diabetes mellitus. CONCLUSIONS: During cesarean section under spinal anesthesia in patients with gestational diabetes mellitus, the rate of development of the sympathetic block is reduced (especially in women who received insulin therapy). At the same time, block regression in these patients occurs much faster, which requires an earlier start of postoperative anesthesia. An increased need for systemic analgesics has been demonstrated during the postoperative period in women with gestational diabetes mellitus, mainly with insulin therapy.
      PubDate: 2024-07-17
      DOI: 10.17816/JOWD629429
      Issue No: Vol. 73, No. 3 (2024)
       
  • Viktor P. Baskakov: life, science, and heritage (on the 100th anniversary
           of his birth)

    • Authors: Vitaly F. Bezhenar, Alexander V. Dyachuk, Dariya V. Fedosova, Ilarion A. Barnash, Maria G. Chmaro, Valeria A. Ageeva
      Pages: 133 - 140
      Abstract: This article sheds light on the personal and professional paths of Professor Viktor Baskakov, who was an outstanding obstetrician-gynecologist, an endometriosis specialist, and the author of the first fundamental scientific works on endometriosis in Russia. The paper explores the milestones of the professor’s scientific career and discusses the peculiarities of clinical work and surgical techniques in the treatment of deep infiltrative endometriosis, in particular. In addition, new methods of management of the early postoperative period, as well as prevention and rehabilitation of gynecological patients are described. Viktor Baskakov was a talented teacher and mentor, a skilled surgeon, a competent scientific and clinical supervisor who had an innovative and bold view of the problems of treatment and diagnosis of endometriosis, which at that time were especially relevant and under-investigated. Special attention is paid to the many memories of colleagues and grateful patients of Professor Viktor Baskakov.
      PubDate: 2024-07-17
      DOI: 10.17816/JOWD630149
      Issue No: Vol. 73, No. 3 (2024)
       
  • Quality of life of patients with uterine fibroids

    • Authors: Natalia V. Aganezova, Sergey S. Aganezov, Maria M. Buriak
      Pages: 5 - 14
      Abstract: BACKGROUND: Currently, there is an elevation in the incidence of uterine fibroids in increasingly younger women of reproductive age. Taking into account the current trend of late motherhood, this cohort of patients is interested in using reliable reversible contraception. Combined hormonal contraceptives meet these criteria and are able to neutralize the clinical manifestations of uterine fibroids, thereby improving the quality of life of patients. At the same time, some combined hormonal contraceptives users may experience a decrease in libido and a change in their psycho-emotional state as a manifestation of the side effects of these drugs. AIM: The aim of this study was to assess the effect of combined hormonal contraceptives on the quality of life in patients with uterine fibroids. MATERIALS AND METHODS: This study involved 100 patients with uterine fibroids (F3–F6 according to classification of the International Federation of Gynecology and Obstetrics, without indications for surgical treatment) and 30 healthy women aged 18 to 49 years. For contraceptive purposes, 40 participants with uterine fibroids used combined hormonal contraceptives containing ethinyl estradiol (group I) and 60 patients with uterine fibroids did not use any medications (group II). The following validated questionnaires were used for patients with uterine fibroids — at the beginning and after 6 months, and for healthy women in the control group (group III) — once upon entry into the study: Short Form-36, Female Sexual Function Index, and Beck Depression Inventory. A comparative statistical analysis of the studied parameters over time was carried out. RESULTS: At baseline, a lower quality of life was noted in patients with uterine fibroids compared to the control group (Short Form-36): 94 ± 6 vs 102 ± 11 points, respectively (p < 0.05). After 6 months, patients in group I showed positive dynamics with increasing in the total Short Form-36 from 95 ± 4 to 98 ± 5 points (p < 0.05) compared to patients in group II: 94 ± 6 and 93 ± 5 points (p > 0.05). We revealed no changes in the Female Sexual Function Index in the study groups — at baseline: 24.8 ± 8.9 (group I), 23.9 ± 9.5 (group II), and 27.8 ± 4.7 (group III); and after 6 months: 26.4 ± 9.2 (group I) and 23.9 ± 10.0 (group II) (p > 0.05 for all comparisons). When comparing the results of a questionnaire on the Beck scale, no dynamics were determined in patients with uterine fibroids, including those who used combined hormonal contraceptives. CONCLUSIONS: The study demonstrated a lower quality of life in patients with uterine fibroids compared to healthy women and an improved quality of life in patients with uterine fibroids using combined hormonal contraceptives. We showed no negative effects of contraceptive drugs on libido and emotional state in women with uterine fibroids who used combined hormonal contraceptives for 6 months.
      PubDate: 2024-05-27
      DOI: 10.17816/JOWD622756
      Issue No: Vol. 73, No. 2 (2024)
       
  • Neonatal outcomes in women with diabetes mellitus — analysis of
           DAPSY data

    • Authors: Roman V. Kapustin, Ekaterina V. Kopteeva, Elena N. Alekseenkova, Olga V. Kovalchuk-Kovalevskaya, Anastasia V. Rybachek, Olga N. Arzhanova, Igor Yu. Kogan
      Pages: 15 - 26
      Abstract: BACKGROUND: Hyperglycemia in pregnancy is associated with short- and long-term implications for children. Nevertheless, the effects of different types of diabetes mellitus and treatment methods on the neonatal outcomes are to be investigated. AIM: The aim of this study was to evaluate the contribution of different types of maternal diabetes mellitus to the risk of adverse neonatal outcomes. MATERIALS AND METHODS: This retrospective cohort study included women (n = 3261) who delivered at the Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg, Russia in 2008–2017. The following comparison groups were used: type 1 diabetes mellitus (n = 506; 1a, continuous subcutaneous insulin injections; 1b, multiple daily insulin injections), type 2 diabetes mellitus (n = 229; 2a, diet; 2b, insulin therapy), gestational diabetes mellitus (n = 2387; 3a, diet; 3b, insulin therapy), and control (n = 139). The main birth outcomes assessed included weight and length of newborns, Apgar score at birth and at 5 minutes after birth, and pathological conditions such as fetal macrosomia, syndrome of infant of mother with gestational diabetes mellitus or diabetic mother (P70.0–P70.1), light (P05.0) or small for gestational age (P05.1), intrauterine growth restriction, prematurity (P07), neonatal hypoglycemia (P70.4), and neonatal respiratory distress syndrome (P22). The secondary birth outcomes assessed included birth trauma (P10–P15), stillbirth (P95), disturbances of cerebral status of newborn (P91), and congenital malformations, deformations and chromosomal abnormalities (Q00–Q99). RESULTS: Pregestational diabetes mellitus is strongly associated with adverse neonatal outcomes. Type 1 diabetes mellitus women had the highest risks for fetal macrosomia and diabetic fetopathy, neonatal hypoglycemia, prematurity, and congenital malformations (odds ratio 3.54, 20.2, 5.59, 4.24 and 3.92 respectively). In type 2 diabetes mellitus patients, the risks of low birth weight, intrauterine growth restriction and birth trauma (odds 9.14, 5.42 and 6.3 respectively) were higher. For women with gestational diabetes mellitus, these risks were lower. CONCLUSIONS: This study provides a comprehensive analysis of the major neonatal pathology in patients with different types of diabetes mellitus, taking into account the treatment method. Preconception care and optimal glycemic control are necessary to reduce the risk of obstetric and perinatal complications in women with pregestational types of diabetes mellitus. Further research into the health status of this cohort of children at a later age is required.
      PubDate: 2024-05-27
      DOI: 10.17816/JOWD624553
      Issue No: Vol. 73, No. 2 (2024)
       
  • Blood flow redistribution in the fetal umbilical-portal venous system in
           pregnancy complicated by diabetes mellitus

    • Authors: Ekaterina V. Kopteeva, Elizaveta V. Shelaeva, Elena N. Alekseenkova, Roman V. Kapustin, Igor Yu. Kogan
      Pages: 27 - 41
      Abstract: BACKGROUND: The fetal liver plays a central role in energy metabolism and is supplied mainly by the vessels of the umbilical-portal venous system. Redistribution of blood flow in this system is a key adaptive response of the fetus to environmental change. AIM: The aim of this study was to evaluate the hemodynamic redistribution in the fetal umbilical-portal venous system in pregnant women with pregestational diabetes mellitus, gestational diabetes mellitus and in healthy pregnant women. MATERIALS AND METHODS: This prospective cohort single-center study was conducted at the Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg between February 2022 and September 2023. The study included 188 patients who made up the following comparison groups: pregestational diabetes mellitus (n = 86), gestational diabetes mellitus (n = 44), and control (n = 58). Patients underwent ultrasound from 30+0 to 41+3 weeks with assessment of venous hemodynamics in the vessels of the umbilical-portal venous system such as the umbilical vein, left portal vein, right portal vein, main portal vein, and ductus venosus. RESULTS: The umbilical vein volumetric blood flow in the I group exceeded that in the II group by 23.60 ml/min/kg and that in the control group by 30.35 ml/min/kg (p < 0.001). The total liver volumetric blood flow in patients with pregestational diabetes mellitus (106.85 ml/min/kg) also exceeded that in the gestational diabetes mellitus group by 28.04 ml/min/kg and that in the control group by 33.73 ml/min/kg (p < 0.001). The umbilical vein and total fetal liver blood flows increased to full-term pregnancy, but, when normalized by the estimated fetal weight, the both flows showed a downward trend at 37–41 weeks of gestation (p < 0.001). No significant differences were revealed in the ductus venosus volumetric blood flow in the study groups. However, there was a significant decrease in the ductus venosus shunt fraction in patients with pregestational diabetes mellitus (16.83 %) by −8.34 % compared to the control group (24.56 %) and by −5.65 % compared to the II group (22.89 %). The downward trend persisted throughout the third trimester of pregnancy and reached its maximum at full-term (p < 0.001). CONCLUSIONS: With pregestational diabetes mellitus, there is a priority redistribution of highly oxygenated blood from the umbilical vein to the right lobe of the fetal liver, accompanied by a decrease in the ductus venosus shunt fraction. This may underlie the pathogenesis of such complications as fetal macrosomia and diabetic fetopathy.
      PubDate: 2024-05-27
      DOI: 10.17816/JOWD625384
      Issue No: Vol. 73, No. 2 (2024)
       
  • Biomarkers of inflammation and neoangiogenesis in premature rupture of
           membranes

    • Authors: Maria A. Morozova, Vitaly F. Bezhenar, Irina V. Kholopova, Alexandra V. Mazing, Tatyana V. Blinova, Ilya V. Smirnov, Olesya A. Grigoryeva
      Pages: 43 - 50
      Abstract: BACKGROUND: Premature rupture of membranes complicates up to 2–10% of full-term pregnancies and up to 40% of all premature pregnancies. It is believed that the main cause of premature rupture of membranes is inflammation caused by both infectious agents and autoimmune processes. Numerous studies are aimed at searching for biomarkers that can predict inflammation in premature rupture of membranes. AIM: The aim of this study was to determine the levels of pro-inflammatory cytokines such as interleukin-6, -18 and procalcitonin, as well as interferon-α and soluble endoglin, in the blood serum of pregnant women with premature rupture of membranes and women in labor with timely discharge of amniotic fluid and evaluate the possibility of using these parameters to optimize obstetric tactics. MATERIALS AND METHODS: This study included 69 patients delivered at the Clinic of Obstetrics and Gynecology of the Academician I.P. Pavlov First Saint Petersburg State Medical University from January 2022 to March 2023. The main study group consisted of 53 pregnant women with premature rupture of membranes, the control group included 16 women with term labor and timely discharge of amniotic fluid, or amniotomy performed in the first stage of labor. The levels of interleukin-6, -18, interferon-α, procalcitonin and soluble endoglin in maternal peripheral blood were assessed using enzyme-linked immunosorbent assay. Pregnancies complicated by severe preeclampsia, placenta abruption and chronic maternal diseases in the acute stage were excluded from the study. RESULTS: At the time of rupture, the minimum gestational age was 33+0 weeks and the maximum age — 41+3 weeks. The median duration of the anhydrous interval was 31.8 hours. No significant differences in interleukin-6, -18, procalcitonin and soluble endoglin concentrations were revealed in the main and control groups, interferon-α level being higher in the comparison group. The median concentration of interferon-α in pregnant women with premature rupture of membranes was 1.64 pg/ml and in women with timely discharge of amniotic fluid — 4.61 pg/ml (p = 0.001). A weak direct correlation was revealed between soluble endoglin and interleukin-18 concentrations (R = 0.26; p = 0.03), as well as a moderate direct correlation between soluble endoglin and procalcitonin levels (R = 0.4; p < 0.001). CONCLUSIONS: The study did not reveal differences in the concentrations of interleukin-6, -18, procalcitonin and soluble endoglin in the comparison groups. A decrease in interferon-α level in the blood in pregnant women increases the risk of developing premature rupture of membranes. The correlations between soluble endoglin and interleukin-18 or procalcitonin concentrations may indicate an association between different mechanisms of the pathogenesis of premature rupture of membranes. In this regard, an integrated approach and analysis of a combination of several cellular bioregulators are eligible to predict infectious complications in premature rupture of membranes.
      PubDate: 2024-05-27
      DOI: 10.17816/JOWD624329
      Issue No: Vol. 73, No. 2 (2024)
       
  • Comparative analysis of endometrium after using levonorgestrel-releasing
           intrauterine system and copper intrauterine device

    • Authors: Victoria A. Pechenikova, Raisa A. Akopyan, Yuliana A. Antipova, Maria V. Volokhova
      Pages: 51 - 61
      Abstract: BACKGROUND: To date, the risks of pelvic inflammatory diseases, including chronic endometritis, associated with the use of various intrauterine contraceptives, have remained debatable. AIM: The aim of this study was to conduct a comparative analysis of the endometrial status in women of reproductive age after the use of copper- or levonorgestrel-releasing intrauterine device. MATERIALS AND METHODS: Morphological and immunohistochemical studies of endometrial biopsies obtained by aspiration Pipelle biopsy were performed after intrauterine device extraction in 18 patients who used a copper-containing intrauterine device and in 12 women who used the levonorgestrel-releasing intrauterine device Mirena. Monoclonal mouse antibodies to CD20, CD138, and α-smooth muscle actin (DAKO, Denmark) were used. Criteria for inclusion of patients in the study are reproductive age, use of an intrauterine device for five years, absence of complications associated with the intrauterine device during its use. Exclusion criteria are a history of pelvic inflammatory diseases, sexually transmitted infections, habitual miscarriage, two or more intrauterine interventions. RESULTS: After using a copper-containing intrauterine device, signs of chronic inflammation were found in the endometrium such as cytogenic stroma fibrosis with pronounced infiltration by inflammatory cells, positive expression of CD138 (33.3% of observations), CD20 (88.9% of observations with an average number of 27.4 ± 5.7), α-smooth muscle actin (up to 70% of the cytogenic stroma area), and the presence of lymphatic follicles consisting of B lymphocytes (33.3% of observations). During the use of the levonorgestrel-releasing intrauterine device, decidual transformation of cytogenic stroma cells, as well as secretion and atrophy of the glandular epithelium, were found in the endometrium. CD20-positive cells were detected in five out of 12 cases (41.6% of observations with an average number of 12.8 ± 4.6). Expression of CD138 and α-smooth muscle actin was not detected in any of the cases. CONCLUSIONS: The use of a copper-containing intrauterine device is associated with a high risk of developing chronic endometritis. The absence of signs of chronic inflammation in the endometrium after the use of a levonorgestrel-releasing intrauterine device is probably due to the protective effect of levonorgestrel on the uterine mucosa. Thus, levonorgestrel-releasing intrauterine devices, in comparison with copper-containing intrauterine devices, have a favorable safety profile relative to the endometrium and can be recommended for women of reproductive age, including those who have not given birth.
      PubDate: 2024-05-27
      DOI: 10.17816/JOWD624301
      Issue No: Vol. 73, No. 2 (2024)
       
  • Differentiated approach to the choice of therapy for stress urinary
           incontinence in women with pelvic floor dysfunction

    • Authors: Elena I. Rusina, Maria M. Zhevlakova, Elizaveta V. Shelayeva, Maria I. Yarmolinskaya
      Pages: 63 - 76
      Abstract: BACKGROUND: Among the symptoms of pelvic floor dysfunction, urinary incontinence is common in young patients. Stress urinary incontinence disrupts psychological health, sexual and social life. The effectiveness of modern conservative treatments for mild stress urinary incontinence in women of reproductive and perimenopausal age is being studied to prevent disease progression and improve the quality of life. AIM: The aim of this study was a comparative assessment of the effectiveness of pelvic floor muscle training using the Tyulpan laser vaginal simulator and paraurethral injections of a high-density hyaluronic biopolymer for the correction of stress urinary incontinence in women of reproductive and perimenopausal age with pelvic floor dysfunction. MATERIALS AND METHODS: We examined 82 patients aged 43.35 ± 6.25 years with mild to moderate stress urinary incontinence combined with grade I to II genital prolapse. After general clinical and special studies, including voiding diaries, Urgency Bother Visual Analogue Scale, cough test, ultrasound of the urethrovesical junction and pelvic floor, 41 women were prescribed a course of remote pelvic floor muscle training under medical supervision using the Tyulpan laser vaginal simulator (group I). 41 patients underwent paraurethral injection of 4.0 ml of high-density hyaluronic biopolymer crosslinked with 1,4-butanediol diglycidyl ether (group II). The effectiveness of therapy was evaluated one, six and 12 months after the start of treatment. RESULTS: After one month, the absence of stress urinary incontinence episodes based on voiding diaries was found in 29.4% of patients in group I and in 85.4% of patients in group II (2.9 times more often) (p < 0.001); after 12 months, in 73.1% of patients in group I and in 36.4% of patients in group II (half as often) (p = 0.011). After one month, a negative cough test was detected in 65.0% of women in group I and in 92.1% of women in group II (1.4 times more often) (p = 0.023). After six months, the results of treatment for stress urinary incontinence based on the cough test were not different and amounted to 80.0% in group I and 71.9% in group II (p = 0.725). When assessing the pelvic floor muscle strength using the Oxford Scale and perineometry, an increase in strength after one and six months was detected in 100% of patients in group I (p < 0.001). Both techniques equally reduced urethral mobility as measured by ultrasound over the one-month follow-up. Pelvic floor muscle training more significantly improved the quality of life of women 12 months after the start of therapy (p < 0.05). CONCLUSIONS: The introduction of high-density hyaluronic biopolymer leads to a rapid and pronounced positive result in the treatment of stress urinary incontinence and an improvement in the quality of life in the short term; it is recommended for patients interested in quickly achieving results, informed about the limited duration of the effect. Regular training of the pelvic floor muscles in biofeedback mode under the remote control of a doctor contributes to better results in the long term. This method is recommended for women who are able to contract the pelvic floor muscles and are ready for regular exercise.
      PubDate: 2024-05-27
      DOI: 10.17816/JOWD629472
      Issue No: Vol. 73, No. 2 (2024)
       
  • Characteristics and dynamics of the emotional condition and mental health
           of women during pregnancy and after childbirth in the COVID-19 pandemic

    • Authors: Svetlana S. Savenysheva, Mariya E. Blokh, Varvara O. Anikina
      Pages: 77 - 88
      Abstract: BACKGROUND: The coronavirus pandemic has been a powerful and long-term stressor, and pregnant women are among the most vulnerable groups in the population. Modern foreign studies have shown an increase in the level of anxiety, depression, and post-traumatic stress disorder in women during pregnancy and after childbirth in the COVID-19 coronavirus pandemic, which, in turn, can affect both the course of pregnancy and childbirth and the development of the child. Meanwhile, there are currently very few domestic studies of these characteristics and their dynamics in women in the pre- and postnatal period. AIM: The aim of this study was to assess the characteristics and dynamics of the emotional condition and mental health of women during pregnancy and after childbirth in the COVID-19 coronavirus pandemic. MATERIALS AND METHODS: In this study, we used the State-Trait Anxiety Inventory by Ch.D. Spilberger, adapted by Yu.L. Khanin; the Achenbach System of Empirically Based Assessment (Adult Self-Report 18–59) by T. Achenbach and L. Rescorla, adapted by E.R. Slobodskaya; the Impact of Event Scale-Revised by D.S. Weiss and C.R. Marmar, adapted by N.V. Tarabrina; socio-biographical questionnaire during pregnancy and after childbirth; and postpartum interview. At the I stage, the study included 248 pregnant women, with the average age of 30.7 (18–44) years and the average gestational age of 31.1 (4–40) weeks. At the II stage, we enrolled 98 women from the initial sample four to six months after childbirth. RESULTS: Our study showed the presence of predominantly average levels of anxiety, a high frequency of depressive disorder and avoidance, cognitive problems and withdrawal, as well as somatic problems during pregnancy. Pandemic-related post-traumatic stress disorder was identified in 7.7% of pregnant women and 6% of women after childbirth. Analysis of the dynamics of the emotional condition and mental health disorders in women before and after childbirth revealed a significant decrease in the levels of post-traumatic stress disorder (p < 0.01), depressive (p < 0.05) and somatic (p < 0.01) disorders, and avoidance disorder (p < 0.05). Predictors of the emotional condition, post-traumatic stress disorder and mental health disorders in women after childbirth are the same as those during pregnancy. CONCLUSIONS: The study showed a high incidence of post-traumatic stress disorder, depression and avoidance disorders with an average level of anxiety in pregnant women during the pandemic. After childbirth, patients experienced a decrease in depressive, somatic and avoidance disorders, as well as post-traumatic stress disorder.
      PubDate: 2024-05-27
      DOI: 10.17816/JOWD109522
      Issue No: Vol. 73, No. 2 (2024)
       
  • CELASTO (Cervical ELASTOgraphy) pilot study — the use of cervical
           elastography during pregnancy

    • Authors: Vladislava V. Khalenko, Ekaterina V. Kopteeva, Olesya N. Bespalova, Olga V. Pachuliia, Ekaterina A. Kornyushina, Igor Yu. Kogan
      Pages: 89 - 98
      Abstract: BACKGROUND: Ultrasound assessment of cervical length is an integral part of a comprehensive examination during pregnancy, but it does not provide a complete picture of structural changes in the cervix. The use of E-Cervix elastography is a promising method to assess cervical remodeling throughout the gestation period. AIM: The aim of this study was to evaluate the possibility of using automated cervical elastography in clinical practice to analyze the main parameters of cervical elasticity and hardness in pregnancy. MATERIALS AND METHODS: This prospective pilot study included 136 patients with singleton pregnancies at gestational ages ranging from 7+0 to 41+0 weeks. Cervical elastography was performed using E-Cervix software of the W10 diagnostic ultrasound system (Samsung Medison Co., Ltd., South Korea) with evaluation of quantitative parameters such as hardness ratio, elasticity contrast index, internal os, external os. RESULTS: Correlation analysis showed that hardness ratio decreased with increasing gestational age (ρ = −0.439) and decreasing cervical length (ρ = 0.408; p < 0.001). In the group of patients with cervical length less than 25 mm, there was a decrease in hardness ratio compared to the control group (48.0 vs. 63.8%, respectively; p < 0.001). The elasticity contrast index score, which reflects cervical tissue heterogeneity, increased with gestational age and cervical shortening (ρ = 0.368 and −0.450, respectively), the parameter being higher in patients with cervical length less than 25 mm [4.73 (IQR 4.21–5.90); p < 0.001]. The increase in internal os and external os with gestational age (ρ = 0.433 and ρ = 0.365, respectively; p < 0.001) indicates softening of the cervix and is accompanied by its shortening. CONCLUSIONS: Results indicate decreased hardness and increased elasticity of the cervix with increasing gestational age and decreased cervical length. E-Cervix technology allows for assessing structural changes in the cervix throughout pregnancy, starting from early gestation.
      PubDate: 2024-05-27
      DOI: 10.17816/JOWD623593
      Issue No: Vol. 73, No. 2 (2024)
       
  • AT-rich interactive domain-containing protein 1A (ARID1A) expression in
           placentas with late fetal growth restriction

    • Authors: Tatiana G. Tral, Sofia R. Yusenko, Gulrukhsor Kh. Tolibova, Igor Yu. Kogan
      Pages: 99 - 108
      Abstract: BACKGROUND: Fetal growth restriction, which is considered as a multifactorial pathology, is a critical problem in obstetrics. The role of mitochondrial dysfunction in the pathogenesis of fetal growth restriction is not yet clear. However, it is known that it leads to oxidative stress, damage to cells and tissues, and dysfunction of key mechanisms for maintaining energy balance, the outcome of which may be the development of placental insufficiency. It is likely that AT-rich interactive domain-containing protein 1A (ARID1A) is involved in the development and function of the human placenta and may be an important marker in the development of fetal growth restriction. AIM: The aim of this study was to evaluate ARID1A protein expression in the placental villous tree in late fetal growth restriction. MATERIALS AND METHODS: This study included 50 placentas from children born at full-term gestation (37–40 weeks). The main study group consisted of placentas with late fetal growth restriction and without major extragenital pathology (n = 35). The control group comprised 15 placentas without fetal growth restriction (n = 15). Histological (n = 50) and immunohistochemical examinations of placentas (15 placentas in the main group and 10 placentas in the control group) using primary monoclonal antibodies to ARID1A were performed. RESULTS: In the study group with fetal growth restriction, chronic placental insufficiency was verified in all cases, dissociated chronic placental insufficiency (25 cases; 71.4%) being predominant, of which 23 cases (92%) were compensated, including 16 cases (69.6%) with moderate circulatory disorders. Hypoplastic chronic placental insufficiency was diagnosed in ten cases (28.6%) and was subcompensated with the presence of pronounced circulatory disorders. In the arteries of the stem villi, the ARID1A protein expression area did not differ between the study groups (p = 0.096), while in the veins in the stem villi with fetal growth restriction, we verified a decrease compared to control (p = 0.05). In the vascular bed of the villi with subcompensated dissociated chronic placental insufficiency, ARID1A protein expression was higher compared to hypoplastic chronic placental insufficiency (p = 0.041). CONCLUSIONS: Chronic placental insufficiency combined with fetal growth restriction is a serious complication of pregnancy with the development of structural and functional abnormalities and dysregulation of placental mechanisms. The ARIDA1A protein expression data obtained, depending on the degree of compensation for chronic placental insufficiency, may indicate the activation of compensatory metabolic mechanisms to maintain the functional activity of the placenta and preserve the viability of the fetus.
      PubDate: 2024-05-27
      DOI: 10.17816/JOWD627609
      Issue No: Vol. 73, No. 2 (2024)
       
  • New ideas about the maternal gut microbiome as a source of fetal
           programming

    • Authors: Viktoria V. Barinova, Dmitry O. Ivanov, Irina O. Bushtyreva, Tatiana L. Botasheva, Ekaterina E. Artouz
      Pages: 109 - 118
      Abstract: New genetic technologies that have emerged and been introduced into practice over the past 20 years, including 16s rRNA sequencing, have significantly expanded our understanding of the microbial composition of the human body. The gut is one of the most densely populated microbial niches in the human body. Numerous studies have shown the relationship of the gut microbiome with various non-communicable diseases, including diabetes mellitus, obesity, allergies and even mental disorders. The perinatal period, as one of the most hormonally dependent ones in human ontogenesis, has a direct impact on the composition of the intestinal microbiota, just as the microbiota itself can be a precursor and etiological cause of pregnancy complications. In this regard, the aim of this review article was to systematize data on the gut microbiota of the maternal body in normal and pathological pregnancy, as well as to analyze data on the interaction of the maternal gut microbiome with the fetal immune system. The review presents data on changes in the maternal intestinal microbiome in normal pregnancy, during infertility, as well as in pregnancy complicated with obesity, gestational diabetes mellitus and preeclampsia. The review also shows how the maternal microbiome is able to “educate” the fetal immune system in utero, thereby preparing the child, who develops in a sterile womb, for extrauterine life surrounded by a large number of various microorganisms. These mechanisms include the direct effect of not only the microorganisms themselves, but also, even largely, their metabolites — primarily short-chain fatty acids. All these presented data allow for concluding that the maternal microbiome is essentially a separate regulatory homeostatic system, along with the immune, endocrine and cardiovascular systems, which may determine the development of certain complications of pregnancy and shape the health of the unborn child. Interventions in the composition of the maternal gut microbiota may be a way to modulate the course of pregnancy and prevent major obstetric syndromes.
      PubDate: 2024-05-27
      DOI: 10.17816/JOWD625424
      Issue No: Vol. 73, No. 2 (2024)
       
  • Management strategies for POSEIDON patients with poor ovarian response to
           ovarian stimulation: а literature review

    • Authors: Yuliya A. Dumanskaya, Alla S. Kalugina
      Pages: 119 - 128
      Abstract: A poor ovarian response to ovarian stimulation is a factor that significantly reduces the effectiveness of in vitro fertilization programs. Managing these patients remains an unresolved issue in assisted reproductive technology programs. The difficulties are largely determined by the heterogeneity of groups of patients with a poor ovarian response and the need for a personalized approach to ovarian stimulation. This review covers the data from the global literature on the management tactics of patients with a poor ovarian response according to the POSEIDON classification, with the aim of increasing the quantity and quality of retrieved oocytes and clinical pregnancy rates.
      PubDate: 2024-05-27
      DOI: 10.17816/JOWD546865
      Issue No: Vol. 73, No. 2 (2024)
       
  • Inflammaging and prognostic markers of endometriosis

    • Authors: Anastasia A. Shteiman, Yulia S. Krylova, Mikhail A. Dokhov, Tatyana S. Zubareva
      Pages: 129 - 136
      Abstract: Inflammaging, an age-associated inflammation, is a cellular stress response caused by DNA damage, activation of oncogenes or inactivation of tumor suppressors, oxidative stress, chemotherapy, mitochondrial dysfunction, or epigenetic changes. Damage to macromolecules leads to the cessation of proliferation due to the activation of pathways such as p53/p21CIP1 and p16INK4a/RB. These form the senescence-associated secretory phenotype (SASP), the molecular/cellular manifestations of which in endometrial cells have features similar to those observed in endometriosis. Presently, there are no uniform diagnostic criteria or established molecular markers that can predict the development and course of endometriosis. In this regard, it is relevant to develop new minimally invasive examination methods, statistically based criteria and molecular markers for early diagnosis and prognosis of endometriosis. This review article is devoted to identifying molecular markers that characterize the pathogenesis of endometriosis during inflaming. The aim of the study was to consider modern ideas about the mechanisms of inflaming and its role in the development of endometriosis to determine possible molecular markers for predicting the course of the pathology. We used the PubMed, Scopus and Google Scholar databases to analyze and systematize the literature over the past ten years. Our review reflects the main molecular mechanisms and prognostic criteria that characterize the development of endometriosis during inflaming.
      PubDate: 2024-05-27
      DOI: 10.17816/JOWD622785
      Issue No: Vol. 73, No. 2 (2024)
       
  • Bilateral anogenital mammary-like glands lactating in the puerperium. A
           clinical case

    • Authors: Natalya V. Kulagina, Dmitry S. Sudakov, Mikhail S. Dobrovolsky
      Pages: 137 - 148
      Abstract: This article presents a rare case of a woman having bilateral anogenital mammary-like glands, lactating in the postpartum period, and a surgical solution to the problem. The histology of the removed tissue corresponded to the morphology of the breast during lactation. No complications occurred after surgery.
      PubDate: 2024-05-27
      DOI: 10.17816/JOWD626636
      Issue No: Vol. 73, No. 2 (2024)
       
  • Possibilities of using lactobacilli metabolites for the treatment and
           prevention of bacterial vaginosis

    • Authors: Alena D. Minakova, Tea A. Dzhibladze, Vladimir M. Zuev
      Pages: 149 - 154
      Abstract: Bacterial vaginosis is one of the most common reasons for pathological discharge from the genital tract in women of reproductive age, which, among other things, is characterized by a high recurrence rate after standard antibacterial treatment. To date, issues related to the prevention and treatment of bacterial vaginosis have remained relevant and unresolved. This review article discusses the feasibility of using lactobacilli metabolites in the treatment and prevention of bacterial vaginosis, taking into account the data accumulated. The use of lactic acid as an additional second stage of bacterial vaginosis treatment can be considered as a way to improve the effectiveness of therapy and patient adherence to treatment, as well as to reduce the likelihood of recurrences.
      PubDate: 2024-05-27
      DOI: 10.17816/JOWD626455
      Issue No: Vol. 73, No. 2 (2024)
       
  • The organ of the Imperial Clinical Midwifery Institute is the forerunner
           of music therapy in Russia

    • Authors: Eduard K. Ailamazyan, Jeanna V. Kniazeva
      Pages: 155 - 162
      Abstract: This review article describes the acquisition and installation of an organ in a scientific and educational medical institution. For the first time, an organ was installed at the Imperial Clinical Midwifery Institute in 1904. The beginning of the ХХ century was marked by the development of music therapy. This could not go unnoticed by the director of the institute D.O. Ott. Nowadays, there is an increasing interest in music therapy. This article touches on the history of the appearance and further fate of the Walcker organ, acquired for the Imperial Clinical Midwifery Institute. We herein discuss the issues of music therapy and its healing effects on patients.
      PubDate: 2024-05-27
      DOI: 10.17816/JOWD627534
      Issue No: Vol. 73, No. 2 (2024)
       
  • Serotonin receptor and serotonin transporter expressions in the placental
           villous tree in gestational diabetes mellitus

    • Authors: Ofelia A. Bettikher, Olga A. Belyaeva, Albina I. Dukovich, Olga M. Vorobeva, Tatiana G. Tral, Gulrukhsor Kh. Tolibova, Victor A. Bart, Igor Yu. Kogan, Irina E. Zazerskaya
      Pages: 5 - 16
      Abstract: BACKGROUND: The serotonergic system during pregnancy plays an important role not only in carbohydrate metabolism, but also in the laying and regulation of the fetoplacental complex, growth and development of the fetus. The study of the expression of placental serotonin 5-HT2A receptor and serotonin transporter (SERT) in gestational diabetes mellitus is foremost for scrutinizing the pathogenesis of perinatal complications, as it may allow for finding new opportunities for their prevention and correction. AIM: The aim of this study was to compare the expression patterns of the serotonin 5-HT2A receptor and SERT in placental tissue in gestational diabetes mellitus and in normal pregnancy. MATERIALS AND METHODS: This comparative cohort study included pregnant women with gestational diabetes mellitus (n = 6) and patients with normal pregnancy (n = 10). The expression of serotonin 5-HT2A receptor (Abcam, USA) and SERT (Bioss Antibodies, USA) was studied in placenta samples from the both study groups by immunohistochemical method. Morphometric analysis was performed using the VideoTest-Morphology 5.2 program (Videotest Ltd., Russia). RESULTS: The relative area of SERT expression in the placenta in gestational diabetes mellitus was higher compared to normal pregnancy (p < 0.001). The relative areas of expression of the serotonin 5-HT2A receptor in the placenta did not differ between the study groups (p = 0.5). CONCLUSIONS: Higher SERT expression in the placentas of patients with gestational diabetes mellitus compared to those from women with normal pregnancies may reflect the level of tension of compensatory mechanisms in gestational diabetes mellitus and the effect of insulin therapy on these mechanisms.
      PubDate: 2024-03-26
      DOI: 10.17816/JOWD562735
      Issue No: Vol. 73, No. 1 (2024)
       
  • Assessment of the impact of COVID-19 experienced at different stages of
           gestation on perinatal outcomes and structural changes in the placenta

    • Authors: Svetlana Yu. Borovaya, Anna V. Yakimova, Tatiana A. Ageeva, Victor A. Mudrov
      Pages: 17 - 28
      Abstract: BACKGROUND: At the beginning of the pandemic COVID-19, the attention of obstetricians and gynecologists was focused on studying the impact of SARS-CoV-2 on obstetric and perinatal outcomes. Currently, the dynamics of mutations in genes encoding SARS-CoV-2 proteins determines the emergence of a large number of new strains of the virus that are highly virulent. Given this fact, the problem of assessing the impact of COVID-19 on pregnancy outcomes also remains relevant. AIM: The aim of this study was to assess the impact of the novel coronavirus infection (COVID-19) transmitted at different stages of gestation on perinatal outcomes and structural changes in the placenta. MATERIALS AND METHODS: In 2022–2023, a prospective analysis of 113 cases of childbirth in women who had the novel coronavirus infection during pregnancy was carried out in obstetric institutions in Novosibirsk. The total sample of subjects was divided into three study groups using cluster analysis. Group 1 included 25 women who had SARS-CoV-2 at a gestation period of up to 16 weeks; Group 2 consisted of 61 patients who underwent COVID-19 at gestation period of 17 to 34 weeks; and Group 3 comprised 27 pregnant women in whom COVID-19 was detected after 34 weeks of pregnancy. The control group included 65 pregnant women who had a negative smear test result for SARS-CoV-2. Pathological examination of the placenta included macro- and microscopic studies. Statistical processing of the results was carried out using the IBM SPSS Statistics Version 25.0 program. RESULTS: The most common fetal distress was observed in patients of Groups 1 and 2 (p = 0.002). We found an inverse correlation between the gestational age at which a woman suffered coronavirus infection and the volumetric density of capillaries and intervillous fibrinoid, as well as the percentage of formation of the syncytial-capillary membrane and villi with symplastic buds. On the contrary, a direct correlation between the gestational age and the volumetric density of connective tissue was found. Intervillusitis was more often observed in the placentas of women of Groups 1 and 2. Histitocytic infiltration was characteristic of the placentas of patients of Group 2. CONCLUSIONS: The frequency of adverse perinatal outcomes and the intensity of structural changes in the placenta depend on the gestation period in which the patient suffered the novel coronavirus infection. The most significant structural changes in the placenta were detected in patients of Group 2.
      PubDate: 2024-03-26
      DOI: 10.17816/JOWD624435
      Issue No: Vol. 73, No. 1 (2024)
       
  • Personalized approach to outpatient management of patients taking
           tamoxifen by gynecologists

    • Authors: Ekaterina O. Golubenko, Marina I. Savelyeva, Vera V. Korennaya, Natalia M. Podzolkova
      Pages: 29 - 39
      Abstract: BACKGROUND: 30% of women with luminal breast cancer receiving adjuvant tamoxifen experience disease recurrence within 15 years. This demonstrates the wide variability in clinical response to tamoxifen. Both nongenetic (age, gender, body mass index, duration of drug use) and genetic factors have been described to influence the high variability of response to tamoxifen. Differences in the genes encoding the enzymes CYP2D6, CYP2C, and CYP3A (CYP2D6*4, CYP3A5*3, CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP2C19*3) and the ABCB1 gene (C3435T) may also be the main factors of susceptibility to the occurrence of undesirable effects when taking tamoxifen, which in turn may lead to decreased patient adherence to therapy. AIM: The aim of this study was to create a concept and an algorithm for a personalized approach to outpatient management of patients taking tamoxifen by a gynecologist in connection with the carriage of polymorphisms of cytochrome P450 and drug transporter genes. MATERIALS AND METHODS: In 2017–2018, the outpatient records of 230 patients with breast cancer were analyzed retrospectively. A single-stage pharmacogenetic study of 120 women with stage I–III luminal breast cancer taking tamoxifen was conducted prospectively for the presence of cytochrome P450 gene polymorphisms using the polymerase chain reaction method and assessing associations with adverse drug reactions, and 54 patients were interviewed after five-year follow-up to assess adherence and satisfaction with medical supervision. RESULTS: The likelihood of developing endometrial hyperplasia has been shown to increase while taking tamoxifen with increasing average age, body mass index, duration of tamoxifen use, and postmenopause. Significant associations have been identified between the carriage of the CYP2D6, CYP2C9, CYP2C19, CYP3A5, and ABCB1 gene polymorphisms and the development of adverse drug reactions. Predictive models have been developed to determine the risk of adverse drug reactions. All studied adverse drug reactions associated with various genetic polymorphisms predominated in the group of patients who stopped taking tamoxifen due to poor intolerance. Gynecologists regularly observed 57.4% of patients. Moreover, the higher the adherence to therapy was, the higher was the regularity of observation by a gynecologist. CONCLUSIONS: A plan for outpatient management of patients receiving adjuvant endocrine therapy with tamoxifen by a gynecologist has been developed.
      PubDate: 2024-03-26
      DOI: 10.17816/JOWD608183
      Issue No: Vol. 73, No. 1 (2024)
       
  • Evaluation of serotonin levels in full-term newborns of diabetic mothers

    • Authors: Nataliia A. Zvereva, Yuliya P. Milyutina, Alexander V. Arutjunyan, Inna I. Evsyukova
      Pages: 41 - 50
      Abstract: BACKGROUND: The growth of neurological and mental diseases in the offspring of patients with pre- and gestational diabetes mellitus determines the need to study the regulatory function of the serotoninergic system of the brain in newborns. This plays a key role in its morphofunctional development in early ontogenesis, which is necessary for timely diagnosis of disorders and prevention of long-term consequences. AIM: The aim of this study was to evaluate serotonin levels in full-term newborns with diabetic fetopathy from mothers with pre- and gestational diabetes mellitus. MATERIALS AND METHODS: The main group consisted of 45 newborns with diabetic fetopathy, of whom 30 individuals were from mothers with type 1 diabetes mellitus and 15 ones from mothers with gestational diabetes mellitus. The control group comprised 20 healthy full-term newborns from healthy mothers without pregnancy complications. Serotonin concentrations were determined in platelet-rich plasma of blood from the umbilical cord vein, and in a platelet suspension prepared from venous blood taken on the first day of life, using high-performance liquid chromatography with electrochemical detection. RESULTS: Platelet-rich plasma serotonin level in umbilical cord blood taken from newborns of the main group was more than two times lower compared to children of healthy mothers. This parameter in venous blood taken from mothers with type 1 diabetes (0.744 ± 0.117 µmol/l) corresponded to that in healthy patients, while in mothers with gestational diabetes mellitus, it was significantly lower and amounted to 0.331 ± 0.071 µmol/l (p < 0.05). Moreover, platelet-rich plasma serotonin level in all newborns correlated with that in their mothers (R = 0.505; p < 0.05). Serotonin levels in venous blood platelets of newborns of the main group was almost 2.5 times lower than in healthy ones. CONCLUSIONS: The data obtained indicate the need to use platelet serotonin values as a biochemical marker of disorders of functional brain development in children with diabetic fetopathy.
      PubDate: 2024-03-26
      DOI: 10.17816/JOWD569397
      Issue No: Vol. 73, No. 1 (2024)
       
  • Minimally invasive correction of stress urinary incontinence in women with
           pelvic floor dysfunction

    • Authors: Elena I. Rusina, Maria M. Zhevlakova, Elizaveta V. Shelayeva, Maria I. Yarmolinskaya
      Pages: 51 - 66
      Abstract: BACKGROUND: Pelvic floor dysfunction is widespread among young women. Stress urinary incontinence is a common manifestation of the dysfunction and, even in mild forms, affects the quality of life of patients. Much attention is focused on finding and improving minimally invasive methods for treating stress urinary incontinence in women of reproductive and perimenopausal age to prevent disease progression and improve quality of life. AIM: The aim of this study was to evaluate the immediate and long-term results of paraurethral injections of a high-density hyaluronic biopolymer for the correction of stress urinary incontinence in women of reproductive and perimenopausal age. MATERIALS AND METHODS: We examined 37 patients aged 44.6 ± 4.7 years with mild to moderate stress urinary incontinence combined with grade I to II genital prolapse. After general clinical and special studies (urination diaries, King’s and Pelvic Organ Prolapse / Urinary Incontinence Sexual Questionnaire, cough test, complex urodynamic study, ultrasound examination of the urethrovesical junction and pelvic floor ultrasound with compression elastography), paraurethral injection of 4.0 ml of the high-density hyaluronic biopolymer crosslinked with 1,4-butanediol diglycidyl ether was performed. The effectiveness of therapy was evaluated 1, 6 and 12 months after the procedure. RESULTS: A negative cough test was detected after one, six and 12 months of follow-up in 96.9, 73.1 and 43.8 % of women, respectively; the absence of stress urinary incontinence episodes according to urination diaries was in 85.7, 61.3 and 35.0 % of patients, respectively. Gradual resorption of the drug was monitored over 12 months of observation. An ultrasound examination showed a decrease in urethral mobility one month after the procedure. According to the results of elastography before treatment, the average value of the strain ratio of paraurethral tissues was 0.50 (0.30–0.69) (p < 0.001), after one and six months — 0.88 (0.76–1.03) and 0.79 (0.66–1.07) (p < 0.001 and p = 0.005 respectively). Thus, the stiffness of the paraurethral tissues of the proximal posterior wall of the urethra increased within six months after the procedure. When observing women after 12 months, the stiffness values of the studied tissues decreased and approached the values before treatment. During the entire observation period, the patients noted a decrease in the degree of discomfort due to problems with urination according to the questionnaires. CONCLUSIONS: The introduction of the high-density hyaluronic biopolymer helps to increase the stiffness of paraurethral tissues and improve the structural support of the urethra in patients with stress urinary incontinence. After the procedure, a 12-month follow-up revealed a decrease or absence of stress urinary incontinence episodes according to urination diaries and the preservation of the positive effect of treatment according to the results of the cough test. A gradual decrease in the effect of therapy is associated with biodegradation of the drug. This method of treating mild forms of stress urinary incontinence is effective for women of reproductive and perimenopausal age who do not plan surgical treatment, are interested in achieving a quick result of therapy and are informed that the effect decreases over time after the procedure.
      PubDate: 2024-03-26
      DOI: 10.17816/JOWD624506
      Issue No: Vol. 73, No. 1 (2024)
       
  • Evaluation of renal function in patients with type 1 diabetes mellitus
           implementing reproductive function in assisted reproductive technology
           protocols

    • Authors: Tatiana V. Veretekhina, Maria I. Yarmolinskaya
      Pages: 67 - 79
      Abstract: The prevalence of type 1 diabetes mellitus has increased significantly among women of reproductive age over the past two decades. Despite improved glycemic control and intensified insulin therapy, patients with diabetes still suffer from many reproductive problems, which often makes this group of patients potential participants in assisted reproductive technology programs under certain conditions. Diabetic nephropathy is one of the most serious complications of type 1 diabetes mellitus. It ranks first in the structure of chronic kidney disease and is a common cause of end-stage renal failure, disability, and mortality. Early diagnosis and identification of specific markers of diabetic nephropathy will allow for timely initiation of nephroprotective therapy to slow the progression of diabetic kidney damage. This review article is based on the results of the PubMed, Frontiers, and ResearchGate search queries from 2016 to 2023. We analyzed worldwide and domestic data on the impact of type 1 diabetes mellitus on kidney function, the influence of sex hormones on diabetic nephropathy, and the importance of the personalized approach to this group of patients at the pre-pregnancy stage, especially those planning treatment within assisted reproductive technology programs.
      PubDate: 2024-03-26
      DOI: 10.17816/JOWD623553
      Issue No: Vol. 73, No. 1 (2024)
       
  • Diabetes mellitus during pregnancy — complications for the fetus and
           newborn

    • Authors: Patimat Kh. Gadzhieva, Lyudmila V. Dikareva
      Pages: 81 - 90
      Abstract: Currently, diabetes mellitus is considered one of the most common problems in obstetrics and neonatology, associated with its high incidence and complications it causes — perinatal loss and morbidity of newborns, as well as further negative consequences for the child’s health. The incidence of diabetes mellitus is increasing in the world every year. According to forecasts of the International Diabetes Federation, there is no tendency to decrease the incidence in the near future. The increase in the incidence of diabetes mellitus is also due to a change in the criteria for diagnosis set out in the Gestational Diabetes Mellitus Treatment Guidelines. In addition, patients often do not understand the seriousness of the complications that occur with the disease, thereby not following the doctor’s treatment recommendations. To date, it has been proven that diabetes mellitus is a main cause of perinatal morbidity and mortality. According to the World Health Organization, even slight hyperglycemia in the mother during pregnancy is associated with the development of diabetic fetopathy. This article provides an analytical review of current literature covering the issues of perinatal and neonatal outcomes in the presence of diabetic fetopathy. Its characteristic phenotypic signs include macrosomia (due to increased fat deposition in subcutaneous tissue associated with increased production of somatotropic hormone) or microsomia (due to primary placental insufficiency), general pastiness, skin hyperemia, characteristic сushingoid-type appearance, body disproportion, puffy face in combination with other signs of immaturity, as well as transient hypertrophic cardiomyopathy and hepatosplenomegaly.
      PubDate: 2024-03-26
      DOI: 10.17816/JOWD394645
      Issue No: Vol. 73, No. 1 (2024)
       
  • Postoperative adhesions in urgent gynecological practice — the analysis
           of etiological and pathophysiological factors

    • Authors: Oksana V. Gudz, Anna N. Sulima
      Pages: 91 - 100
      Abstract: The adhesive process in the abdomen in the postoperative period is still a stumbling block for modern medicine. This is due to the fact that surgical activity is increasing, but there is no common solution for precaution. Complications associated with adhesions after urgent gynecological interventions are some of the causes of infertility, which becomes a problem for not only healthcare and society, the patient and their future, but also the government, as it leads to population decline. This review is focused on the study of the adhesive process etiology in surgical gynecology and the pathogenesis traits. We analyzed the literature on the Web of Science, eLibrary, Scopus, and PubMed/Medline using the following keywords: “adhesions,” “adhesive process,” “review,” “operations,” “pathogenesis of formation of adhesions,” and “reproductive dysfunction”. The research included full-text sources and literature reviews on the studied subject. Articles not related directly to the topic of the adhesive process in the postoperative period were excluded from the review. This literature review has demonstrated that despite the ongoing research of scientists all over the world into postoperative adhesion, its etiology and pathogenesis remain not fully understood and disclosed. This dictates the need to continue studying the adhesive process and searching for new solutions in prevention. As far as the attention of surgeons and reproductive specialists is focused on the issues of preventing the adhesive process, we are confident that in the near future, scientists will find a unified solution to this complex problem and practical healthcare specialists will successfully implement it.
      PubDate: 2024-03-26
      DOI: 10.17816/JOWD562924
      Issue No: Vol. 73, No. 1 (2024)
       
  • Gestational diabetes mellitus as a risk factor for neuropsychiatric
           pathology in offspring

    • Authors: Inna I. Evsyukova
      Pages: 101 - 111
      Abstract: This review article summarizes current ideas about gestational diabetes mellitus as an independent risk factor for long-term neuropsychiatric morbidity in offspring. Herein, we describe the genetic programming patterns of morphofunctional brain development during intrauterine life, which provide the basis for short- and long-term functions of the central nervous system. The results of experimental and clinical studies are presented that explain the pathophysiological mechanisms of the harmful effects on the fetal brain of hyperglycemia, hyperinsulinemia, hyperlepthyremia, oxidative stress, and systemic inflammation in the mother with pregnancy complicated by diabetes mellitus. We also discuss structural brain abnormalities and neuropsychiatric consequences. The article substantiates the need for the prevention of neuropsychiatric diseases in the offspring of women with obesity and other concomitant pathology at the stage of family planning, and at the onset of pregnancy, the expediency of early screening, treatment of gestational diabetes mellitus and neuroprotection in the perinatal period of the child’s life.
      PubDate: 2024-03-26
      DOI: 10.17816/JOWD624209
      Issue No: Vol. 73, No. 1 (2024)
       
  • Hypotensive therapy in obstetric practice

    • Authors: Aydar M. Ziganshin, Alina A. Maksyutova
      Pages: 113 - 123
      Abstract: Arterial hypertension remains a leading cause of maternal morbidity and mortality while leading to significant economic costs in health care. Properly selected treatment tactics allow for prolonging pregnancy and levelling out various complications arising from the disease. However, there are still some questions about the effectiveness and safety of prescribed therapy due to possible side effects of the drugs. The aim of this study was to evaluate the efficacy and complications of hypotensive therapy during pregnancy, childbirth and the postpartum period. We analyzed the literature on eLibrary, Scopus, Cochrane Library, PubMed.
      PubDate: 2024-03-26
      DOI: 10.17816/JOWD569131
      Issue No: Vol. 73, No. 1 (2024)
       
  • Mechanisms of injury in the nervous system in fetuses with growth
           restriction

    • Authors: Igor P. Nikolayenkov, Dmitry V. Shakalis, Dmitry S. Sudakov
      Pages: 125 - 136
      Abstract: This review article analyzes current literature on the mechanisms of damage to the nervous system in fetal growth restriction, which is a leading cause of perinatal morbidity and mortality in the economically developed countries. In some cases, this condition is associated with damage to the fetal nervous system, the symptoms of which can persist throughout life. Foundation of the effective pathogenetic therapy for intrauterine growth restriction during pregnancy would significantly reduce child mortality, morbidity and disability, and ease the financial burden on the healthcare system and social institutions.
      PubDate: 2024-03-26
      DOI: 10.17816/JOWD501748
      Issue No: Vol. 73, No. 1 (2024)
       
  • Pathogenetic traits of preeclampsia in COVID-19. A relevant literature
           review

    • Authors: Kseniia A. Rudenko, Valentina V. Ishkaraeva, Irina E. Zazerskaya
      Pages: 137 - 148
      Abstract: The aim of this study was to present the latest data on the association of preeclampsia and coronavirus infection and on the preeclampsia-like syndrome, and to analyze the current literature on the pathogenetic relationships between COVID-19 and preeclampsia and on morphological changes in placental tissue in patients with these gestational complications. A significant portion of studies indicate an increased risk of developing preeclampsia in patients with coronavirus infection during pregnancy, regardless of gestational age, especially in severe COVID-19, but other researchers report no association between coronavirus infection and the onset of preeclampsia. The supposed pathogenetic connection between these pathologies consists in the development of systemic endothelial dysfunction and dysregulation of the renin-angiotensin-aldosterone system, while the direct effect of SARS-CoV-2 on the placentation is poorly understood and is a subject of debate. A new concept of the so-called “preeclampsia-like syndrome” has been introduced, which presumably occurs in patients with a severe form of the novel coronavirus infection as its extrapulmonary manifestation. The measurement of the ratio of soluble fms-like tyrosine kinase-1 activity to the level of placental growth factor ratio has been proposed as a differential diagnostic test between preeclampsia and the preeclampsia-like syndrome, but its prognostic value remains ambiguous. The morphological examination of placentas in patients with coronavirus infection and preeclampsia indicates the signs of maternal and fetal vascular malperfusion. The literature on the association between coronavirus infection and preeclampsia remains controversial, however, the better half of the researchers is indicative of a significant increase in the risk of developing this serious complication in pregnant women with COVID-19, especially for its severe form. New information about the preeclampsia-like syndrome, as well as the virtual absence of studies of placental morphology in patients with preeclampsia and coronavirus infection during pregnancy, dictate the need for further study to better understand the association between these two pathologies, determine the possibilities of patient surveillance and prevent complications.
      PubDate: 2024-03-26
      DOI: 10.17816/JOWD595741
      Issue No: Vol. 73, No. 1 (2024)
       
  • Modern view of preconception carrier screening

    • Authors: Olga E. Talantova, Tatyana B. Postnikova, Anastasiia A. Mikhailova, Olesya N. Bespalova
      Pages: 149 - 156
      Abstract: The article provides an overview current literature covering the issues of preconception carrier screening. Hereditary diseases make a large contribution to disability, deterioration in quality of life and reduction in life expectancy, primarily among the child population. Treatment and rehabilitation of patients with hereditary diseases is accompanied by serious economic costs, as well as psychological and social problems. In many countries, preference for preventive measures over treatment measures is enshrined in law. Awareness of preconception carrier screening among non-genetic doctors and the general population is currently very low. The development and introduction into practical healthcare of effective approaches to the prevention of hereditary diseases is of paramount importance in reproductive medicine. Conducting expanded carrier screening before pregnancy will allow for identifying in future parents the latent carriage of hereditary diseases responsible for infertility, miscarriage, infant or child mortality, and fetal development abnormalities, as well as formulating optimal tactics to prepare and introduce pregnancy, including the use of diagnostic and preventive measures.
      PubDate: 2024-03-26
      DOI: 10.17816/JOWD623670
      Issue No: Vol. 73, No. 1 (2024)
       
  • New International Federation of Gynecology and Obstetrics ovulatory
           disorders classification system 2022. Diagnostic assessment of ovulatory
           dysfunction

    • Authors: Yuliya V. Kovalyova
      Pages: 157 - 170
      Abstract: Until recently, researchers and clinicians have used the World Health Organization classification of ovulatory disorders (1973), which was based on the levels of gonadotropins and estrogens in the blood serum (mainly follicle-stimulating hormone) and classified ovulatory disorders depending on the hypothalamic-pituitary-ovarian axis dysfunction levels. This review article presents a new classification system for ovulation disorders developed by the International Federation of Gynecology and Obstetrics (FIGO) in 2022. The first level of this classification system is based on an anatomical approach (hypothalamus, pituitary gland, ovaries), which is complemented by a separate category for polycystic ovary syndrome. At the second level, each anatomical category is classified according to the putative etiopathogenetic mechanisms underlying ovulation disorders. The third level suggests the presence of specific nosologies, which represent the direct cause of ovulation disorders. This new classification should be used after a preliminary examination that reveals the presence of an ovulation disorder. This review discusses various ovulation disorders and provides tools for their diagnosis in accordance with international guidelines and domestic recommendations.
      PubDate: 2024-03-26
      DOI: 10.17816/JOWD191384
      Issue No: Vol. 73, No. 1 (2024)
       
 
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  Subjects -> SOCIAL SCIENCES (Total: 1648 journals)
    - BIRTH CONTROL (22 journals)
    - CHILDREN AND YOUTH (262 journals)
    - FOLKLORE (30 journals)
    - MATRIMONY (16 journals)
    - MEN'S INTERESTS (16 journals)
    - MEN'S STUDIES (90 journals)
    - SEXUALITY (56 journals)
    - SOCIAL SCIENCES (937 journals)
    - WOMEN'S INTERESTS (44 journals)
    - WOMEN'S STUDIES (175 journals)

WOMEN'S STUDIES (175 journals)                     

Showing 1 - 146 of 146 Journals sorted by number of followers
Women & Criminal Justice     Hybrid Journal   (Followers: 313)
Gender & Society     Hybrid Journal   (Followers: 101)
Urban Studies     Hybrid Journal   (Followers: 81)
Gender & Development     Hybrid Journal   (Followers: 74)
Gender, Work & Organization     Hybrid Journal   (Followers: 68)
Signs: Journal of Women in Culture and Society     Full-text available via subscription   (Followers: 58)
Political Studies     Hybrid Journal   (Followers: 46)
Gender, Place & Culture: A Journal of Feminist Geography     Hybrid Journal   (Followers: 45)
Journal of Gender Studies     Hybrid Journal   (Followers: 43)
Violence Against Women     Hybrid Journal   (Followers: 39)
Gender Studies     Open Access   (Followers: 38)
Hypatia : A Journal of Feminist Philosophy     Hybrid Journal   (Followers: 33)
Journal of Feminist, Gender and Women Studies     Open Access   (Followers: 32)
Feminist Media Studies     Hybrid Journal   (Followers: 28)
Gender & History     Hybrid Journal   (Followers: 27)
Feminist Studies     Full-text available via subscription   (Followers: 27)
Feminist Theory     Hybrid Journal   (Followers: 26)
Feminist Legal Studies     Hybrid Journal   (Followers: 25)
Communication Papers : Media Literacy & Gender Studies     Open Access   (Followers: 25)
Gender and Education     Hybrid Journal   (Followers: 24)
Feminist Review     Hybrid Journal   (Followers: 24)
Gender Issues     Hybrid Journal   (Followers: 23)
Journal of Women's History     Full-text available via subscription   (Followers: 23)
Journal of Gender, Social Policy & the Law     Open Access   (Followers: 23)
Political Studies Review     Hybrid Journal   (Followers: 22)
Black Women, Gender & Families     Full-text available via subscription   (Followers: 22)
International Feminist Journal of Politics     Hybrid Journal   (Followers: 21)
Social Politics: International Studies in Gender, State & Society     Hybrid Journal   (Followers: 21)
Studies in Gender and Sexuality     Hybrid Journal   (Followers: 21)
Feminist Criminology     Hybrid Journal   (Followers: 20)
Feminism & Psychology     Hybrid Journal   (Followers: 19)
Gender and Language     Hybrid Journal   (Followers: 19)
Journal of Middle East Women's Studies     Full-text available via subscription   (Followers: 19)
Early Modern Women : An Interdisciplinary Journal     Full-text available via subscription   (Followers: 18)
European Journal of Women's Studies     Hybrid Journal   (Followers: 17)
Assuming Gender     Open Access   (Followers: 17)
Contemporary Women's Writing     Hybrid Journal   (Followers: 16)
Psychology & Sexuality     Hybrid Journal   (Followers: 16)
Australian Feminist Studies     Hybrid Journal   (Followers: 15)
Gender, Technology and Development     Hybrid Journal   (Followers: 15)
Women's History Review     Hybrid Journal   (Followers: 15)
Women and Music: A Journal of Gender and Culture     Full-text available via subscription   (Followers: 15)
WSQ: Women's Studies Quarterly     Full-text available via subscription   (Followers: 15)
Australian Feminist Law Journal     Hybrid Journal   (Followers: 15)
Religion and Gender     Open Access   (Followers: 15)
Women Against Violence : An Australian Feminist Journal     Full-text available via subscription   (Followers: 13)
Atlantis : Critical Studies in Gender, Culture & Social Justice     Open Access   (Followers: 13)
Journal of Women Politics & Policy     Hybrid Journal   (Followers: 12)
Advances in Gender Research     Full-text available via subscription   (Followers: 12)
Nashim : A Journal of Jewish Women's Studies & Gender Issues     Full-text available via subscription   (Followers: 11)
Journal of Family Studies     Hybrid Journal   (Followers: 11)
Indian Journal of Gender Studies     Hybrid Journal   (Followers: 10)
Journal of Feminist Studies in Religion     Full-text available via subscription   (Followers: 10)
Psychology of Women Quarterly     Hybrid Journal   (Followers: 10)
Gender and Behaviour     Open Access   (Followers: 9)
International Journal of Gender Studies in Developing Societies     Hybrid Journal   (Followers: 9)
Clio. Women, Gender, History     Open Access   (Followers: 9)
Feminist Anthropology     Open Access   (Followers: 9)
Women's Studies International Forum     Hybrid Journal   (Followers: 8)
Tulsa Studies in Women's Literature     Full-text available via subscription   (Followers: 8)
Affilia     Hybrid Journal   (Followers: 7)
Feminist Theology     Hybrid Journal   (Followers: 7)
Women's Studies : An inter-disciplinary journal     Hybrid Journal   (Followers: 7)
Frontiers : A Journal of Women Studies     Full-text available via subscription   (Followers: 7)
Feminist Formations     Full-text available via subscription   (Followers: 7)
Feminist German Studies     Full-text available via subscription   (Followers: 7)
The Women : Annual Research Journal of Gender Studies     Open Access   (Followers: 7)
Genre, sexualité & société     Open Access   (Followers: 6)
Girlhood Studies     Full-text available via subscription   (Followers: 6)
Lilith: A Feminist History Journal     Full-text available via subscription   (Followers: 6)
Journal of Interdisciplinary Feminist Thought     Open Access   (Followers: 6)
History of Women in the Americas     Open Access   (Followers: 6)
Women, Gender, and Families of Color     Full-text available via subscription   (Followers: 6)
Women in Higher Education     Hybrid Journal   (Followers: 6)
Feminist Philosophy Quarterly     Open Access   (Followers: 6)
Journal of Lesbian Studies     Hybrid Journal   (Followers: 5)
Meridians : feminism, race, transnationalism     Full-text available via subscription   (Followers: 5)
Women's Writing     Hybrid Journal   (Followers: 5)
International Journal of Gender and Entrepreneurship     Hybrid Journal   (Followers: 5)
Women's Studies in Communication     Hybrid Journal   (Followers: 5)
Women in Judaism : A Multidisciplinary e-Journal     Open Access   (Followers: 5)
GÉNEROS - Multidisciplinary Journal of Gender Studies     Open Access   (Followers: 5)
Journal of Women and Gender in Higher Education     Hybrid Journal   (Followers: 5)
Journal of Women & Aging     Hybrid Journal   (Followers: 4)
Nora, Nordic Journal of Women's Studies     Hybrid Journal   (Followers: 4)
Women: A Cultural Review     Hybrid Journal   (Followers: 4)
Legacy : A Journal of American Women Writers     Full-text available via subscription   (Followers: 4)
Canadian Journal of Women and the Law     Full-text available via subscription   (Followers: 4)
Canadian Woman Studies     Full-text available via subscription   (Followers: 4)
Journal of International Women's Studies     Open Access   (Followers: 4)
Case Reports in Women's Health     Open Access   (Followers: 4)
Michigan Journal of Gender and Law     Free   (Followers: 4)
Columbia Journal of Gender and Law     Open Access   (Followers: 4)
Journal of Feminist Family Therapy     Hybrid Journal   (Followers: 3)
Women & Therapy     Hybrid Journal   (Followers: 3)
ninepatch : A Creative Journal for Women and Gender Studies     Open Access   (Followers: 3)
UCLA Women's Law Journal     Open Access   (Followers: 3)
ABO : Interactive Journal for Women in the Arts, 1640-1830     Open Access   (Followers: 3)
Feminist Modernist Studies     Hybrid Journal   (Followers: 3)
Whatever : A Transdisciplinary Journal of Queer Theories and Studies     Open Access   (Followers: 3)
Journal of the European Society of Women in Theological Research     Full-text available via subscription   (Followers: 2)
NAN Nü     Hybrid Journal   (Followers: 2)
International Journal of Feminist Approaches to Bioethics     Full-text available via subscription   (Followers: 2)
Feminist Teacher     Full-text available via subscription   (Followers: 2)
Recherches féministes     Full-text available via subscription   (Followers: 2)
NASPA Journal About Women in Higher Education     Hybrid Journal   (Followers: 2)
William & Mary Journal of Women and the Law     Open Access   (Followers: 2)
Journal of Women's Entrepreneurship and Education (JWEE)     Open Access   (Followers: 2)
Cadernos Pagu     Open Access   (Followers: 1)
Revista Estudos Feministas     Open Access   (Followers: 1)
Les cahiers du CEDREF     Open Access   (Followers: 1)
Journal of Ayn Rand Studies     Full-text available via subscription   (Followers: 1)
Palimpsest : A Journal on Women, Gender, and the Black International     Full-text available via subscription   (Followers: 1)
PALASTReN : Jurnal Studi Gender     Open Access   (Followers: 1)
Cadernos de Gênero e Diversidade     Open Access   (Followers: 1)
La Manzana de la Discordia     Open Access   (Followers: 1)
Open Gender Journal     Open Access   (Followers: 1)
Sexuality, Gender & Policy     Hybrid Journal   (Followers: 1)
Ambigua : Revista de Investigaciones sobre Género y Estudios Culturales     Open Access   (Followers: 1)
Queer Cats Journal of LGBTQ Studies     Open Access   (Followers: 1)
Sextant : Revue de recherche interdisciplinaire sur le genre et la sexualité     Open Access  
Simone de Beauvoir Studies     Full-text available via subscription  
Kvinder, Køn & Forskning / Women, Gender & Research     Open Access  
DUODA : estudis de la diferència sexual     Open Access  
iQual : Revista de Género e Igualdad     Open Access  
Tidsskrift for kjønnsforskning     Open Access  
Journal of Obstetrics and Women's Diseases     Open Access  
Musas : Revista de Investigación en Mujer, Salud y Sociedad     Open Access  
Akdeniz Kadın Çalışmaları ve Toplumsal Cinsiyet Dergisi / Mediterranean Journal of Gender and Women’s Studies     Open Access  
Nomadías     Open Access  
Sawwa : Jurnal Studi Gender     Open Access  
Cuestiones de género: de la igualdad y la diferencia     Open Access  
Antyajaa : Indian Journal of Women and Social Change     Hybrid Journal  
Lectora : Revista de Dones i Textualitat     Open Access  
Tijdschrift voor Genderstudies     Full-text available via subscription  
EGALITA     Open Access  
Revista Feminismos     Open Access  
querelles-net : Rezensionszeitschrift für Frauen- und Geschlechterforschung     Open Access  
Investigaciones Feministas     Open Access  
Agenda     Partially Free  
La Aljaba     Open Access  
Storia delle Donne     Open Access  
Mora (Buenos Aires)     Open Access  
International Journal of Impotence Research     Hybrid Journal  
Hawwa     Hybrid Journal  
Aspasia     Full-text available via subscription  

           

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JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
 


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