Subjects -> BIOLOGY (Total: 3331 journals)
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BIOPHYSICS (53 journals)

Showing 1 - 53 of 53 Journals sorted alphabetically
Acta Biochimica et Biophysica Sinica     Hybrid Journal   (Followers: 6)
Advanced NanoBiomed Research     Open Access   (Followers: 2)
Annual Review of Biophysics     Full-text available via subscription   (Followers: 26)
Archives of Biochemistry and Biophysics     Hybrid Journal   (Followers: 19)
BBA Advances     Open Access  
BBA Bioenergetics     Hybrid Journal   (Followers: 6)
BBA Biomembranes     Hybrid Journal   (Followers: 12)
Biochemical and Biophysical Research Communications     Hybrid Journal   (Followers: 21)
Biochemistry and Biophysics Reports     Open Access  
Biochimica et Biophysica Acta (BBA) - General Subjects     Hybrid Journal   (Followers: 15)
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids     Hybrid Journal   (Followers: 8)
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease     Hybrid Journal   (Followers: 14)
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research     Hybrid Journal   (Followers: 13)
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics     Hybrid Journal   (Followers: 12)
Bioinspired, Biomimetic and Nanobiomaterials     Hybrid Journal   (Followers: 2)
Biophysical Chemistry     Hybrid Journal   (Followers: 10)
Biophysical Journal     Hybrid Journal   (Followers: 50)
Biophysical Reports     Open Access  
Biophysical Reviews and Letters     Hybrid Journal   (Followers: 5)
Biophysics     Hybrid Journal   (Followers: 8)
Biophysics Reports     Open Access  
BMC Biophysics     Open Access   (Followers: 4)
Cell Biochemistry and Biophysics     Hybrid Journal   (Followers: 7)
Computational and Mathematical Biophysics     Open Access   (Followers: 1)
Current Topics in Biophysics     Open Access   (Followers: 3)
Doklady Biochemistry and Biophysics     Hybrid Journal   (Followers: 1)
European Biophysics Journal     Hybrid Journal   (Followers: 4)
Food Biophysics     Hybrid Journal   (Followers: 4)
Freshwater Biology     Hybrid Journal   (Followers: 33)
GSTF Journal of BioSciences     Open Access   (Followers: 2)
IEEE Life Sciences Letters     Hybrid Journal  
IEEE Nanotechnology Express     Hybrid Journal   (Followers: 18)
Indian Journal of Biochemistry and Biophysics (IJBB)     Open Access   (Followers: 2)
International Journal of Biochemistry and Biophysics     Open Access   (Followers: 1)
International Journal of Biophysics     Open Access  
Journal of Biopharmaceutical Statistics     Hybrid Journal   (Followers: 23)
Journal of Biophotonics     Hybrid Journal   (Followers: 1)
Journal of Biophysical Chemistry     Open Access   (Followers: 4)
Journal of Biophysics and Structural Biology     Open Access   (Followers: 2)
Journal of Medicine, Physiology and Biophysics     Open Access   (Followers: 5)
Journal of Physical Chemistry & Biophysics     Open Access   (Followers: 3)
Membranes and Membrane Technologies     Full-text available via subscription   (Followers: 2)
Nanomedicine Research Journal     Open Access  
Nanomedicine: Nanotechnology, Biology and Medicine     Hybrid Journal   (Followers: 7)
Natural Products and Bioprospecting     Open Access   (Followers: 2)
Nature Communications     Open Access   (Followers: 433)
PMC Biophysics     Open Access  
Progress in Biophysics and Molecular Biology     Hybrid Journal   (Followers: 1)
Progress in Physical Geography     Hybrid Journal   (Followers: 11)
Quarterly Reviews of Biophysics     Hybrid Journal   (Followers: 3)
Radiation and Environmental Biophysics     Hybrid Journal   (Followers: 3)
Research & Reviews : A Journal of Life Sciences     Open Access  
Statistics in Biopharmaceutical Research     Full-text available via subscription   (Followers: 16)
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Doklady Biochemistry and Biophysics
Journal Prestige (SJR): 0.257
Citation Impact (citeScore): 1
Number of Followers: 1  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1607-6729 - ISSN (Online) 1608-3091
Published by Springer-Verlag Homepage  [2659 journals]
  • On the Sorption-Stimulating Preparations Influence on Seed Germination

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      Abstract: The influence of various types of impacts on soil samples on the germination of seeds and the development of seedlings in comparison with sand (allelotoxicity) was studied. It is established that various types of soil sample preparation can significantly affect their allelotoxicity. It is shown that initial soil stimulated seedling development (+23%). Drying to air-dry state with further wetting increased the allelotoxicity to –27%. Autoclaving of samples (148°C, 4.5 atm) increased their allelotoxicity to –77%. The data obtained suggest that allelotoxins can exist in the soil in active and fixed forms and pass from the fixed form to the active form under various types of impacts on the soil. The study of the influence of the allelotoxicity of soil samples on the application efficiency of sorption-stimulating preparation (SSP), used for the pre-sowing treatment of spring wheat seeds, shows that the application effect of SSP monotonically decreases when allelotoxicity increases. The calculations show that the amount of sorbent used to protect seeds from allelotoxins is 3–4 orders of magnitude lower than the amount that can fix allelotoxins contained in soils. It follows from above that the development of seed seedlings is affected only by a small part of allelotoxins present in soils in the active state.
      PubDate: 2021-07-01
       
  • Changes in the Time-Domain of Heart Rate Variability and Corticosterone
           after Surgical Trauma to the Nasal Septum in Rats

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      Abstract: The aim of the work was to study changes in the time range of heart rate variability (HRV) against the background of changes in the concentration of corticosterone in blood plasma in rats after surgical trauma to the nasal septum. Septoplasty was simulated in 30 mature male Wistar rats weighing 210–290 g. ECG was recorded with subsequent analysis of the time domain of HRV, as well as blood sampling to estimate changes in the concentration of corticosterone in the blood plasma was performed. As a result, SDNN significantly increased in comparison with the control on days 2 and 3 (p < 0.001) but decreased on days 4–5 (p < 0.001) and 6 (p < 0.01). rMSSD changed in waves with two irregular peaks on days 1 and 6. SDNN/rMSSD, in comparison with the 1st day of the postoperative period, increased on the 2nd day, continued to increase (p < 0.05), and then began to decrease on day 4 (p < 0.01). The total HRV power of was low throughout the postoperative period (p < 0.001), except for day 3, when it was equal to the control data. The increase in the total power index fell on day 3 after the operation (p <0.01), after which its decline was observed again. The concentration of corticosterone in the blood plasma in rats was significantly higher than before (p < 0.001). On postoperative day 2 to 4, its plateau was determined. Simulation of septoplasty leads to changes in the time range of HRV, an increase in the concentration of corticosterone in the blood plasma in rats with its maximum at the time of surgery and 24 h later, and the formation of a “plateau” on postoperative days 2 to 4, which coincides with the changes in HRV.
      PubDate: 2021-07-01
       
  • To the Academician Alexander Spirin 90th Anniversary from Informosomes to
           the World of mRNP

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      Abstract: The main stages and achievements in the investigation of the fate of mRNA in eukaryotic cells, which began half a century ago with the discovery of informosomes by A.S. Spirin, there are discussed. The results of even the most recent studies confirm Spirin’s hypotheses about the structure and function of the informosomes, now called mRNPs. In the bibliography, we present only small part of the published articles in this field. The full list is too large.
      PubDate: 2021-07-01
       
  • Study of the N-Terminal Domain Homodimerization in Human Proteins with
           Zinc Finger Clusters

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      Abstract: CTCF belongs to a large family of transcription factors with clusters of C2H2-type zinc finger domains (C2H2 proteins) and is a main architectural protein in mammals. Human CTCF has a homodimerizing unstructured domain at the N-terminus which is involved in long-distance interactions. To test the presence of similar N-terminal domains in other human C2H2 proteins, a yeast two-hybrid system was used. In total, the ability of unstructured N-terminal domains to homodimerize was investigated for six human C2H2 proteins with an expression profile similar to CTCF. The data indicate the lack of the homodimerization ability of these domains. On the other hand, three C2H2 proteins containing the structured domain DUF3669 at the N-terminus demonstrated homo- and heterodimerization activity.
      PubDate: 2021-07-01
       
  • GRUSP, an Universal Stress Protein, Is Involved in Gibberellin-dependent
           Induction of Flowering in Arabidopsis thaliana

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      Abstract: The effect of T-DNA insertion in the 3'-UTR region of Arabidopsis thaliana At3g58450 gene encoding the Germination-Related Universal Stress Protein (GRUSP) was studied. It was found that under a long-day condition this mutation delays transition to flowering of grusp-115 transgenic line that due to a reduced content of endogenous bioactive gibberellins GA1 and GA3 in comparison to the wild-type plants (Col-0). Exogenous GA accelerated flowering of both lines but did not change the time of difference in the onset of flowering between Col-0 and grusp-115. In addition to changes in GA metabolism, grusp-115 evidently has disturbances in realization of the signal that induces flowering. This is confirmed by the results of gene expression of the floral integrator FLOWERING LOCUS T (FT) and the floral repressor FLOWERING LOCUS C (FLC), which are key flowering regulators and acting opposite. We hypothesize that the formation of grusp-115 phenotype can also be affected by a low expression level of FT due to up-regulated FLC expression.
      PubDate: 2021-07-01
       
  • Mutations of Phosphorylation Sites in MSL1 Protein Do Not Affect Dosage
           Compensation in Drosophila melanogaster

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      Abstract: Proteins MSL1 and MSL2 form the core of the Drosophila dosage compensation complex, which specifically binds to the X chromosome of males. Phosphorylation of certain amino acid residues was previously shown to regulate MSL1 activity. In the present work, transgenic lines of Drosophila expressing mutant variants of the MSL1 protein were obtained, in which amino acids undergoing phosphorylation were replaced. As a result, it was shown that inactivation of phosphorylation sites does not affect the efficiency of specific binding of the dosage compensation complex to the X chromosome of males and its functional activity.
      PubDate: 2021-07-01
       
  • Relationship Estimation of Cell Mobility Proteins Level with Processes of
           Proteolysis and Lymphogenic Metastasis in Breast Cancer

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      Abstract: The biological aggressiveness of a tumor is determined by the ability of tumor cells to invade and metastasize which is a consequence of their acquisition of a number of phenotypic characteristics. Remodeling of the actin cytoskeleton occurs during cell migration which is carried out by various groups of actin binding proteins in the regulation of which proteasomes and calpains play an important role. Therefore the study of the relationship of proteins associated with cell motility with the processes of lymphogenous metastasis as well as the assessment of the regulatory role of intracellular proteases in these processes is extremely important for fundamental oncology. This study demonstrates the associations of actin-binding proteins with the activity of proteasomes and calpain, which are specific for tumors and metastases of the mammary gland. We proposed a possible scheme of the relationship of intracellular systems with the actin-binding proteins. The results obtained expand the fundamental understanding of the processes of tumor progression and can also be used in the search for proteins-targets for therapeutic action in molecular targeted cancer therapy.
      PubDate: 2021-07-01
       
  • Selection of Laboratory Mice for the Cognitive Task Successful Solution
           and for the Inability to Solve It

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      Abstract: Using the selected mouse strain EX as the founding population (selection for extrapolation ability) three selection generations of mice were obtained, which were selected for successful solution of object permanence test (plus-sub-strain) and for lack of such solution (minus-sub-strain). The successful solution required not only the ability to operate the object permanence rule (by J. Piajet), but the performance of complicated action (executive function) which was significantly higher in plus-substrain, and this is the unique example of successful selection for cognitive trait.
      PubDate: 2021-07-01
       
  • Dioscorea deltoidea Leaf Extract (DDLE) Attenuates Cisplatin-Induced
           Ovarian Injury via Regulation of Oxidative Stress

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      Abstract: The present study investigated Dioscorea deltoidea leaf extract (DDLE) for treatment of cisplatin-induced ovarian injury in rat model. DDLE treatment of the cisplatin-induced ovarian injury rats suppressed Follicle-stimulating hormone (FSH) release and promoted the estrogen E2 level in serum samples. Development of follicles was increased while as damage to ovarian cortex on day 14, 28, and 42 was inhibited in cisplatin-induced ovarian injury rats on treatment with DDLE. In cisplatin-induced ovarian injury rat model oxidative stress showed a significant increase because of reduction in the level of antioxidant enzyme activity. However, DDLE treatment led to a prominent increase in activity of antioxidant enzyme compared to the control group. Moreover, DDLE treatment regulated the expression of Nuclear factor erythroid 2-related factor 2 protein in cisplatin-induced ovarian injury rats. In conclusion, DDLE treatment prevents cisplatin-induced ovarian injury through inhibition of malondialdehyde (MDA) level and upregulation of superoxide dismutase (SOD) and catalase (CAT) activity.
      PubDate: 2021-07-01
       
  • Exogenic Melatonin Reduces the Toxic Effect of Polymetallic Stress on
           Barley Plants

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      Abstract: The effect of melatonin on growth parameters, the photochemical activity of photosystem II (PS II), the content of the main photosynthetic pigments, and lipid peroxidation in barley plant leaves under polymetallic stress were studied. Melatonin reduces the toxic effect of polymetals on biomass accumulation, root growth, and maintenance of the assimilating surface. The protective action of the hormone is based on its ability to reduce the intensity of oxidative stress by maintaining the level of carotenoids and increasing the activity of superoxide dismutase, but not by regulating the photochemical activity of chloroplasts. The effectiveness of melatonin does not depend on the duration of exposure. The data obtained can be the basis for optimizing the use of melatonin as a plant priming inducer.
      PubDate: 2021-07-01
       
  • Chemoprotective Effect of Daphnetin in Doxorubicin Treated Esophageal
           Cancer Stem Cell Xenograft Tumor Mouse

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      Abstract: Background: Chemotherapy drugs commonly used for cancer therapy, but chemotherapy has limitation due to side effects. Current studies suggest natural products are reducing the side effects of chemotherapy medicines. In this study, we examined the side effects of doxorubicin (Dox) in esophageal cancer cells (CSCs) derived tumors in vivo. Methods: Esophageal cancer cells (YMI) were treated in vitro with daphnetin (DAP) along with DOX. The MTT assay was used for estimating the cell viability and Annexin/7-AAD was used for the determination of apoptosis. Cell cycle arrest was conducted using the PI-staining method. The potential effect of DAP was evaluated by the estimation of oxidative stress such as total antioxidant capacity (TAC), malondialdehyde (MDA) and superoxide dismutase (SOD) and body weight in the xenograft mice. Results: DAP can protect Dox cell toxicity by suppressing cell apoptosis of ESCC. DAP arrest the cells as S-phase. In vivo experimental study showed that Dox simultaneously with DAP decreases the tumor size along with increased body weight in the nude mice compared to Dox alone treated group mice. Dox along with the DAP exhibited less systemic toxicity and reduced oxidative stress fraction circulation. Conclusion: The result suggests that daphnetin may be used as an adjuvant therapy to reduce the systemic toxicity of chemotherapeutic agents, such as DOX, in stem cell treatment with ESCC cancer.
      PubDate: 2021-07-01
       
  • Effect of Hypochlorite- and Peroxide-Induced Oxidation of Fibrinogen on
           the Fibrin Structure

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      Abstract: Using the methods of dynamic and elastic light scattering and confocal laser scanning microscopy, the damage in the spatial fibrin structure during peroxide- and hypochlorite-induced oxidation of fibrinogen was studied. Peroxide had a weak effect on the structural organization of fibrin, whereas hypochlorite caused the formation of abnormal fibrin with reduced individual fiber diameter and decreased porosity. Measurements of the size distributions of the native and oxidized fibrinogen revealed a decrease in the hydrodynamic size of the oxidized fibrinogen molecule with an increase in the concentration of oxidizers. These results indicate that the hydrophobicity of fibrinogen surface increased and its colloidal stability decreased. The possible role of oxidative sites in the assembly of structurally abnormal fibrin is analyzed.
      PubDate: 2021-07-01
       
  • Effect of the Entomopathogenic Fungus Beauveria bassiana on the
           Development of Faba Bean (Vicia faba) Diseases in the Field Conditions

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      Abstract: Several ascomycetous entomopathogenic fungi, including species in the genera Beauveria, are plant symbionts/endophytes and are termed as endophytic insect-pathogenic fungi. It was shown that the fungus Beauveria bassiana (BBK-1 strain) successfully colonized Vicia faba bean plants in laboratory and field conditions of Western Siberia. The B. bassiana reisolate passed through the plants had significantly higher antagonistic activity against phytopathogens in comparison with the primary stem of entomopahogenic fungi. Pre-sowing faba bean seeds treatment reduced the level of infection of the seed material with phytopathogens, significantly decrease the development and prevalence of root rot disease. A decrease in the disease development index (chocolate spot, powdery mildew, fusariosis and other spots diseases) was found as a result of the use of B. bassiana. The effectiveness and prolonged action of B. bassiana on plants opens up new opportunities both in the creation of biological products and in molecular-genetic research and selection of certain pairs of plants and fungi based on the principle of the greatest synergy.
      PubDate: 2021-07-01
       
  • Reusable System for Phenol Detection in an Aqueous Medium Based on
           Nanodiamonds and Extracellular Oxidase from Basidiomycete Neonothopanus
           nambi

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      Abstract: A reusable system for phenol determination in an aqueous medium was obtained by adsorption of extracellular oxidase from fungus Neonothopanus nambi onto modified nanodiamonds (MND) synthesized by detonation. It was found that the enzyme strongly binds to MND and exhibits catalytic activity in the reaction of co-oxidation of phenol with 4-aminoantipyrine without the addition of hydrogen peroxide. In the presence of the MND–oxidase complex, a significantly (by an order of magnitude) higher yield of the reaction product is recorded as compared to the yield in the presence of a free enzyme; the mechanism of the revealed effect is discussed. Model experiments have demonstrated the multiple use of the MND–oxidase complex for testing phenol in aqueous samples. The immobilized enzyme exhibits functional activity during long-term (2 months) storage of the MND–oxidase complex at 4°C. The data obtained create the prerequisites for using the created system in environmental monitoring of water pollution with phenol.
      PubDate: 2021-07-01
       
  • Chemical Induction of Trophoblast Hypoxia by Cobalt Chloride Leads to
           Increased Expression of DDIT3

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      Abstract: Choriocarcinoma cells BeWo b30 are used to model human placental trophoblast hypoxia using cobalt (II) chloride and hydroxyquinoline derivative (HD) as chemical inducers of hypoxia-inducible factor (HIF). In this study, it was shown that both substances activate the hypoxic pathway and the epithelial–mesenchymal transition and inhibit the pathways of cell proliferation. However, CoCl2 caused activation of the apoptosis pathway, increased the activity of effector caspases 3 and 7, and increased the expression of the unfolded protein response target DDIT3. The mTORC1 pathway was activated upon exposition to CoCl2, while HD suppressed this pathway, as it happens during real trophoblast hypoxia. Thus, effect of CoCl2 on BeWo cells can be a model of severe hypoxia with activation of apoptosis, while HD mimics moderate hypoxia.
      PubDate: 2021-07-01
       
  • Ipomoea staphylina Attenuates Potassium Dichromate-Induced Nephrotoxicity
           in Wistar Rats via Antioxidant and Antiapoptotic Effects

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      Abstract: Occupational and environmental exposure to chromium compounds leads to nephrotoxicity to humans and animals due to the overproduction of ROS. Our study was aimed to demonstrate the shielding effect of hydroethanolic extract of Ipomoea staphylina (HEIS) bark on male Wistar rats challenged with potassium dichromate (K2Cr2O7). Division of animals was done in 4 groups’ viz., normal control, K2Cr2O7 control, K2Cr2O7+HEIS (100 mg/kg), and K2Cr2O7+HEIS (200 mg/kg). Except for the normal control group, other groups were challenged with a single dose (subcutaneous) of K2Cr2O7 (15 mg/kg) and then treated with HEIS (100 and 200 mg/kg) for 1 week. It was observed that animals treated with K2Cr2O7 showed a notable increase in serum creatinine, blood urea, and BUN and dwindles in protein level. These changes were significantly reversed after a 1-week treatment with HEIS (100 and 200 mg/kg). Moreover, HEIS (100 and 200 mg/kg) showed a remarkable improvement in the activity of antioxidant enzymes (GPx, CAT, and SOD) and decreased the levels of TNF-α and IL-1β in the kidney. Furthermore, treatment with HEIS (100 and 200 mg/kg) notably decreased the activity of caspase-3 and improved the level of HO-1 especially in the K2Cr2O7+ HEIS (200 mg/kg) group. Also, the histopathological study of the kidney supported the protective effects of HEIS. Hence, HEIS bark holds a notable protective effect against K2Cr2O7-induced nephrotoxicity in rats.
      PubDate: 2021-07-01
       
  • Assessment of the Relative Biological Efficiency of Pencil Beam Scanning
           of Protons in Mice in Vivo

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      Abstract: The effect of proton pencil beam scanning in the dose range of 4.5–15 Gy on the radiosensitivity of mice under irradiation in two regions of the Bragg curve was studied according to the criteria of 30-day survival, dynamics of death, and average lifespan of mice. The relative biological effectiveness (RBE) value of protons relative to X-ray radiation before and at the Bragg peak determined by the LD50/30 index was 0.86 and 0.94, respectively, and by the criterion of 30-day survival at a dose of 6.5 Gy it was 0.83 and 0.84, respectively. With similar RBE values for protons in different regions of the Bragg curve, significant differences in the dynamics of the course of radiation sickness were revealed, which indicates different damage to critical systems and organs of animals and the induction of compensatory mechanisms involved in the formation of stress responses at the organismal level.
      PubDate: 2021-07-01
       
  • Boerhaavia diffusa Extract Acts as a Specific Antituberculosis Agent in
           Vitro Against Mycobacterium tuberculosis H37Rv Infection

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      Abstract: The present study investigated Boerhaavia diffusa extract against Mycobacterium tuberculosis H37Rv (M.tb) infection in vitro and explored the underlying mechanism. The study demonstrated that Boerhaavia diffusa extract significantly (p < 0.05) reduced RAW 264.7 and A549 cell viability in concentration dependent manner. In BEAS-2B, NuLi-1 cells and splenocytes no significant (p > 0.05) reduction in viability was observed on treatment with 2.5 to 20 mg/L concentrations of Boerhaavia diffusa. The M. tb‑induced increase in TNF‑α expression was significantly (p < 0.05) reversed by Boerhaavia diffusa treatment in RAW 264.7 and BEAS-2B cells. Moreover, Boerhaavia diffusa treatment significantly (p < 0.05) inhibited M.tb‑induced increase in IL-6 and IL‑1β expression in RAW 264.7 and BEAS-2B cells. Boerhaavia diffusa treatment of RAW 264.7 and BEAS-2B cells significantly (p < 0.05) reversed M.tb‑induced increase in iNOS and COX‑2 expression. Additionally, in Boerhaavia diffusa treated cells M.tb‑induced increase in NO release was significantly (p < 0.05) reduced compared to untreated cells. In summary, Boerhaavia diffusa treatment inhibits pro-inflammatory cytokine production, NO release and regulate immunomodulatory mediators in M.tb‑infected RAW 264.7 and BEAS-2B cells. Therefore, Boerhaavia diffusa may be developed as a therapeutic agent for treatment of M.tb‑infection.
      PubDate: 2021-07-01
       
  • The Recombinant Luciferase of the Fungus Neonothopanus nambi : Obtaining
           and Properties

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      Abstract: A key component of the recently described bioluminescent system of higher fungi is luciferase, a new class of proteins. The properties of fungal luciferase and their relationship with its structure are interesting both for improving autoluminescent systems already created on its basis and for creating new ones. Therefore, it is extremely important to understand the spatial structure of this protein. We have performed heterologous expression and purification of Neonothopanus nambi luciferase, obtained a protein suitable for subsequent crystallization, and also determined some biochemical properties of the recombinant luciferase.
      PubDate: 2021-05-01
      DOI: 10.1134/S1607672921010051
       
  • Immortalization of Human Keratinocytes Using the Catalytic Subunit of
           Telomerase

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      Abstract: A new stable line of human keratinocytes was obtained. The cells have altered morphology, both abnormal chromosomal composition and expression of keratinocyte markers, do not show contact inhibition, could be cultured in various media and have limited stratification ability in vitro. Upon transplantation into nude mice the cells have tumorigenic properties.
      PubDate: 2021-05-01
      DOI: 10.1134/S1607672921010014
       
 
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