Subjects -> BIOLOGY (Total: 3268 journals)
    - BIOCHEMISTRY (248 journals)
    - BIOENGINEERING (143 journals)
    - BIOLOGY (1548 journals)
    - BIOPHYSICS (53 journals)
    - BIOTECHNOLOGY (243 journals)
    - BOTANY (233 journals)
    - CYTOLOGY AND HISTOLOGY (32 journals)
    - ENTOMOLOGY (67 journals)
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    - ORNITHOLOGY (29 journals)
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    - ZOOLOGY (142 journals)

BIOPHYSICS (53 journals)

Showing 1 - 52 of 52 Journals sorted alphabetically
Acta Biochimica et Biophysica Sinica     Hybrid Journal   (Followers: 5)
Advanced NanoBiomed Research     Open Access  
Annual Review of Biophysics     Full-text available via subscription   (Followers: 24)
Archives of Biochemistry and Biophysics     Hybrid Journal   (Followers: 17)
BBA Advances     Open Access   (Followers: 4)
BBA Bioenergetics     Hybrid Journal   (Followers: 5)
BBA Biomembranes     Hybrid Journal   (Followers: 11)
Biochemical and Biophysical Research Communications     Hybrid Journal   (Followers: 17)
Biochemistry and Biophysics Reports     Open Access  
Biochimica et Biophysica Acta (BBA) - General Subjects     Hybrid Journal   (Followers: 12)
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids     Hybrid Journal   (Followers: 6)
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease     Hybrid Journal   (Followers: 12)
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research     Hybrid Journal   (Followers: 10)
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics     Hybrid Journal   (Followers: 11)
Bioinspired, Biomimetic and Nanobiomaterials     Hybrid Journal   (Followers: 3)
Biophysical Chemistry     Hybrid Journal   (Followers: 8)
Biophysical Journal     Hybrid Journal   (Followers: 46)
Biophysical Reports     Open Access   (Followers: 5)
Biophysical Reviews and Letters     Hybrid Journal   (Followers: 5)
Biophysics     Hybrid Journal   (Followers: 8)
Biophysics Reports     Open Access  
BMC Biophysics     Open Access   (Followers: 4)
Cell Biochemistry and Biophysics     Hybrid Journal   (Followers: 6)
Current Topics in Biophysics     Open Access   (Followers: 2)
Doklady Biochemistry and Biophysics     Hybrid Journal   (Followers: 1)
European Biophysics Journal     Hybrid Journal   (Followers: 4)
Food Biophysics     Hybrid Journal   (Followers: 3)
Freshwater Biology     Hybrid Journal   (Followers: 31)
GSTF Journal of BioSciences     Open Access  
IEEE Life Sciences Letters     Hybrid Journal  
IEEE Nanotechnology Express     Hybrid Journal   (Followers: 18)
Indian Journal of Biochemistry and Biophysics (IJBB)     Open Access   (Followers: 3)
International Journal of Biochemistry and Biophysics     Open Access   (Followers: 1)
International Journal of Biophysics     Open Access  
Journal of Biopharmaceutical Statistics     Hybrid Journal   (Followers: 23)
Journal of Biophotonics     Hybrid Journal   (Followers: 1)
Journal of Biophysical Chemistry     Open Access   (Followers: 3)
Journal of Biophysics and Structural Biology     Open Access   (Followers: 2)
Journal of Medicine, Physiology and Biophysics     Open Access  
Journal of Physical Chemistry & Biophysics     Open Access  
Membranes and Membrane Technologies     Full-text available via subscription  
Nanomedicine Research Journal     Open Access  
Nanomedicine: Nanotechnology, Biology and Medicine     Hybrid Journal   (Followers: 5)
Natural Products and Bioprospecting     Open Access   (Followers: 2)
Nature Communications     Open Access   (Followers: 310)
PMC Biophysics     Open Access  
Progress in Biophysics and Molecular Biology     Hybrid Journal   (Followers: 1)
Progress in Physical Geography     Hybrid Journal   (Followers: 11)
Quarterly Reviews of Biophysics     Hybrid Journal   (Followers: 3)
Radiation and Environmental Biophysics     Hybrid Journal   (Followers: 3)
Research & Reviews : A Journal of Life Sciences     Open Access  
Statistics in Biopharmaceutical Research     Full-text available via subscription   (Followers: 15)
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Cell Biochemistry and Biophysics
Journal Prestige (SJR): 0.581
Citation Impact (citeScore): 2
Number of Followers: 6  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1559-0283 - ISSN (Online) 1085-9195
Published by Springer-Verlag Homepage  [2537 journals]
  • Galanin enhanced insulin-mediated intracellular signaling by regulating
           the stability of membrane-localized insulin/IR

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      Abstract: Previous studies have shown that insulin has the important regulatory effect on the intestinal tract. However, until now, the biological properties of insulin on intestinal cell has not been revealed. Therefore, in the current research, we first studied the cell characteristics and signaling profiles of insulin in the intestinal cell model, and found that insulin can be internalized into the cytoplasm in a time-dependent manner. After internalization, insulin transported into different type of endosomes. More importantly, we explored the effect of galanin on insulin-mediated signaling pathways (galanin is a polypeptide composed of 29 amino acid residues, galanin is widely distributed in the central and peripheral nervous system and has a variety of biological activities), and found that galanin can increase insulin sensitivity by regulating insulin receptor (IR)-mediated signal transduction pathways. We further study the potential molecular mechanism by which galanin enhances insulin sensitivity, and found that galanin could increase the time of insulin acting on the cell membrane. Further experiments showed that galanin could stabilize the membrane-localized insulin/IR, which may be an important new potential mechanism by which galanin improves the biological activity of insulin. This study laid the foundation for exploring the relationship between galanin and insulin sensitivity.
      PubDate: 2022-01-08
       
  • BADH-NAD+-K+ Complex Interaction Studies Reveal a New Possible Mechanism
           between Potassium and Glutamic 254 at the Coenzyme Binding Site

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      Abstract: Betaine aldehyde dehydrogenase (BADH EC 1.2.1.8) catalyzes the irreversible oxidation of betaine aldehyde to glycine betaine using NAD+ as a coenzyme. Incubation of porcine kidney BADH (pkBADH) with NAD+ decreases the catalytic cysteine (C288) reactivity. Potassium ion increases the pkBADH affinity by the coenzyme. This work aimed to analyze pkBADH and NAD+ interaction in the presence and absence of K+ using 1H NMR to identify the amino acids that interact with NAD+ and/or K+ to understand the regulation process of pkBADH-NAD+ complex formation mediated by the K+ ion and their impact on the substrate binding and catalysis. Nuclear magnetic resonance spectra of pkBADH were obtained in the presence and absence of NAD+ and K+. The results show a chemical shift of the signals corresponding to the catalytic glutamic that participates in the transfer of H+ in the reaction of the pkBADH-NAD+-K+ complex formation. Furthermore, there is a widening of the signal that belongs to the catalytic cysteine indicating higher rigidity or less grade of rotation of the structure, which is consistent with the possible conformations of C288 in the catalytic process; in addition, there is evidence of changes in the chemical environment that surrounds NAD+.
      PubDate: 2022-01-04
       
  • Natural Biosurfactant as Antimicrobial Agent: Strategy to Action Against
           Fungal and Bacterial Activities

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      Abstract: Natural surfactants have gained importance as the usage of synthetic surfactants shows economical aspects, health, and environmental effect. This study examined the anti-microbial activity of safflower seed waste (Ssw) isolated surfactant against dandruff-causing Malassezia furfur and skin diseases causing bacterial strains. Saponin was the major component and non-ionic surfactants derived from plants, which have a special molecular structure with hydrophilic glycoside backbone and lipophilic triterpene derivative. The antimicrobial activity of isolated surfactants was confirmed by the MIC and kill-time assays. Our results showed that the isolated saponin may interact with the cell wall and membrane first and destroy the cell wall and membranes, which finally results in bacterial death. Besides, isolated saponin penetrates the cytoplasmic membrane or enters inside the cell after the destruction of cell structure, and then inhibits the normal synthesis of DNA and proteins that are required for bacterial growth. These results suggested that the effects of the Ssw isolated saponin on the growth inhibition of selected bacterial strains may be at the molecular level rather than only physical damage. Extraction of Biosurfactant (saponin) from Safflower seed waste and its antimicrobial activity.
      PubDate: 2022-01-04
       
  • Correction: Heme Oxygenase 1 in Vertebrates: Friend and Foe

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      PubDate: 2021-12-06
       
  • Discovery of Plasma Membrane-Associated RNAs through APEX-seq

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      Abstract: In addition to nucleic acids, a variety of other biomolecules have also been found on the plasma membrane. Although researchers have realized that RNA has the ability to bind to membrane vesicles in vitro, little is known about whether and how RNA connects to the plasma membrane of the cell. The combination of high-throughput sequencing and in situ labeling methods provides an innovative approach for large-scale identification of subcellular RNAs. Here, we applied the recently published method APEX-seq and identified 75 RNAs related to the plasma membrane, in which lncRNA PMAR72 (plasma membrane-associated RNA AL121772.1) has a considerable affinity with sphingomyelin (SM) and localizes within distinct membrane foci. Our findings will provide some new evidence to elaborate the relationship between RNA and the plasma membrane of mammalian cells.
      PubDate: 2021-12-01
       
  • Valvular Endothelial Cell Response to the Mechanical Environment—A
           Review

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      Abstract: Heart valve leaflets are complex structures containing valve endothelial cells, interstitial cells, and extracellular matrix. Heart valve endothelial cells sense mechanical stimuli, and communicate amongst themselves and the surrounding cells and extracellular matrix to maintain tissue homeostasis. In the presence of abnormal mechanical stimuli, endothelial cell communication is triggered in defense and such processes may eventually lead to cardiac disease progression. This review focuses on the role of mechanical stimuli on heart valve endothelial surfaces—from heart valve development and maintenance of tissue integrity to disease progression with related signal pathways involved in this process.
      PubDate: 2021-12-01
       
  • In Vitro Anticancer Activity of Novel Co(II) and Ni(II) Complexes of
           Non-steroidal Anti-inflammatory Drug Niflumic Acid Against Human Breast
           Adenocarcinoma MCF-7 Cells

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      Abstract: Herein, we report the synthesis, characterization and anticancer activity of six novel complexes of non-steroidal anti-inflammatory drug niflumic acid with Co(II) and Ni(II). In vitro cytotoxicity screening in MCF-7, HepG2 and HT-29 cancer cell lines showed that the complex 3 [Co(nif)2(met)(4-pic)] and complex 6 [Ni(nif)2(met)(4-pic)] among all the complexes exhibited the highest cytotoxicity against MCF-7 cells with IC50 values of 11.14 µM and, 41.47 µM, respectively. Besides, all the complexes exhibited significantly higher selectivity towards mouse fibroblast 3T3L1 cells. Further mechanistic studies with both complexes on MCF-7 cells revealed their cytotoxic action through the mitochondrial-dependent apoptotic pathway causing an increase oxidative/nitrosative stress, decrease in mitochondrial membrane potential (ΔΨm), inducing the multicaspase activation and arresting the cell cycle at S phase. q-PCR analysis resulted in an increase in the expression of the apoptotic marker proteins bax, p53 and caspase-3 and -8 in MCF-7 cells, but a decrease in the expression of antiapoptotic bcl-2 gene. Moreover, both complexes induced the apoptosis through the inhibition of PI3K/Akt signaling pathway by decreasing the expression of PI3K and increasing dephosphorylation form of Akt protein. These results provide a significant contribution to the explanation of the anticancer mechanisms of these complexes in MCF-7 cells.
      PubDate: 2021-12-01
       
  • IGF-1R Transported to the Cell Nuclei to Regulate the Proliferation of
           Breast Cancer Cells

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      Abstract: Under normal physiological conditions, IGF-1 (insulin-like growth factor-1) has important biological effects. However, many studies have found that IGF-1 is closely related to the occurrence and development of breast cancer. But up to now, the cellular properties of IGF-1 have not been systematically explored in breast cancer cell. It is well-known that the cellular properties and behaviors of IGF-1/IGF-1R are closely related to its biological functions. In the current study, we used the breast cancer cell line as a model to explore the biological characteristics of IGF-1/IGF-1R, and found that IGF-1/IGF-1R can be internalized into the cytoplasm. In addition, we also found that IGF-1R can also enter cell nuclei under the mediation of IGF-1. Further research found that the nuclear-localized IGF-1R has important potential biological effects, which is closely associated to the proliferation of breast cancer cell, this may be achieved by regulating IGF-1R-mediated intracellular signaling. The current research has laid the foundation for investigating the relationship between IGF-1/IGF-1R system and the occurrence and development of breast cancer.
      PubDate: 2021-12-01
       
  • Pectin Oligosaccharides Enhance α2,6-Sialylation Modification that
           Promotes Apoptosis of Bladder Cancer Cells by Targeting the Hedgehog
           Pathway

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      Abstract: Although pectin oligosaccharide (POS) can inhibit the growth and proliferation of gastric, colon, prostate, breast, melanoma, and leukemia cells, its effect on bladder cancer remains unknown. Therefore, screening and identification of factors associated with the sensitivity of bladder cancer to drugs and elucidation of their molecular mechanisms will help provide a theoretical basis for establishing postoperative systemic chemotherapy for patients with bladder cancer. We showed that POS promoted the apoptosis of bladder cancer cells, and this finding was consistent with enhanced α2,6-sialylation post-modification. Moreover, POS activated the Hedgehog pathway, the inhibition of which regulated the tumorigenicity of bladder cancer cells in vivo. These findings were consistent with our results in vitro. We conclude that POS promotes the apoptosis of bladder cancer and offers new insights and evidence for the development of individualized treatment strategies. Schema of molecular events underlying POS-induced inhibition of bladder cancer cell proliferation.
      PubDate: 2021-12-01
       
  • miR-21 Exerts Anti-proliferative and Pro-apoptotic Effects in LPS-induced
           WI-38 Cells via Directly Targeting TIMP3

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      Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease, which was caused by a complex interplay of inflammatory responses and chronic damage. miR-21 is increased in patients with IPF, but its function in the embryonic lung-derived diploid fibroblasts cells subjected to LPS is elusive. miRNA expression profile was obtained from GEO database and target genes of miRNAs were forecasted by TargetScan. To mimic the LPS-induced injury, different concentrations of LPS were applied to treat WI-38 cells. Functional in vitro experiments were conducted to examine the role of miR-21 and TIMP3. Luciferase report assay was performed to verify the relationship between miR-21 and TIMP3. qRT-PCR, western blotting, and ELISA were conducted to detect the levels of the related miRNAs, proteins, and inflammatory factors. miR-21 presented higher levels in interstitial pneumonia patients and LPS-induced WI-38 cells. Overexpression of miR-21 was negatively correlated with the proliferative capability of LPS-treated WI-38 cells. miR-21 directly targets TIMP3. TIMP3 restored the suppressive impact of miR-21 mimic on the proliferation, while TIMP3 alleviated the promoting impact of miR-21 mimic on the apoptosis of WI-38 cells treated by LPS. miR-21 inhibited Bcl-2 but increased Bax, cleaved caspase-3, and cleaved caspase-9. Besides, miR-21 elevated the levels of IL-6 and IL-β but reduced the IL-10, which were weakened by TIMP3. Totally, miR-21 aggravated the LPS-induced lung injury and modulated inflammatory responses by targeting TIMP3.
      PubDate: 2021-12-01
       
  • miR-4306 Suppresses Proliferation of Esophageal Squamous Cell Carcinoma
           Cell by Targeting SIX3

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      Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers and the primary cause of cancer-related mortality in China. micoRNA plays a vital role during tumor initiation and malignant progression. miR-4306 has been reported to negatively regulate aggressive cell phenotypes in triple-negative breast cancer (TNBC). Nevertheless, the function of miR-4306 in ESCC was still not clear. In this study, we detected miR-4306 expression by quantitative real-time reverse transcription-PCR (qRT-PCR) and found that miR-4306 expression was downregulated in human ESCC tissue samples and cell lines. Moreover, miR-4306 overexpression could restrain ESCC cell proliferation, migratory and invasive ability and epithelial-mesenchymal transition (EMT), promote cell apoptosis after treatment with or without cisplatin. In contrast, inhibiting the expression of miR-4306 showed the opposing results. Furthermore, we explored the molecular mechanism of effects of miR-4306 and found that miR-4306 inhibited the expression of SIX3 by interaction with SIX3 3′UTR in ESCC cells, and SIX3 overexpression significantly reversed the effect of miR-4306-mediated ESCC cells proliferation. The current study provided evidence of miR-4306 as a tumor suppression gene in ESCC.
      PubDate: 2021-12-01
       
  • Different Changing Patterns of Three NOS–NO System Activities after
           Ischemia–Reperfusion in Rabbit with AMI

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      Abstract: NOS–NO system activity is closely correlated with ischemia–reperfusion injury (IRI) and NOS subtypes were suggested to play different roles in IRI. In this work, the activity of serum NOS, NO levels, and ischemic necrosis after reperfusion in rabbit with AMI at different time was studied. We also explored the NOS–NO system activity changes and its correlation with myocardial ischemia and necrosis. It shows that after reperfusion in rabbits with AMI, NO–NOS system activities present different changes at each time point due to inactivation of NO and iNOS activation, and different experimental animals, ischemia–reperfusion degree, and length of time will also lead to different research results. Therefore, it is necessary to conduct dynamic observation on animals from different species at multi-temporal point under the state of NOS–NO system activities, and simultaneously detect inflammatory factor, MDA, and SOD indexes. Therefore, it is a must to conduct relevant drug research studies to make NOS–NO system activities maintain the level in favor of ideal myocardial ischemia reperfusion.
      PubDate: 2021-12-01
       
  • Effects of Chemotherapy for Metastatic Colorectal Cancer on the TGF-β
           Signaling and Related miRNAs hsa-miR-17-5p, hsa-miR-21-5p and
           hsa-miR-93-5p

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      Abstract: Metastatic colorectal cancer (mCRC) patients are treated with standard chemotherapeutic drugs in the form of FOLFOX and FOLFIRI regimens. There are no reliable markers that could predict response to chemotherapy for mCRC. TGF-β signaling which interacts with microRNA (miRNA) network has important roles in tumor progression and chemotherapy resistance, thus the interplay between TGF-β signaling and miRNAs could be crucial for treatment response. The aim of this study was to analyze the effect of chemotherapy for mCRC on TGF-β signaling and related miRNAs. Hsa-miR-17-5p, hsa-miR-21-5p and hsa-miR-93-5p were selected out of 316 miRNAs with multiple targets within the TGF‐β signaling by in silico analysis. SW620 cells were treated with chemotherapeutic drugs for mCRC for 1, 3 and 6 days and expression of selected miRNAs, PAI-1, CDH1 and VIM was measured. Expression of TGF‐β signaling-related hsa-miR-17-5p, hsa-miR-21-5p and hsa-miR-93-5p was time-dependently altered in SW620 cells treated with chemotherapeutics for mCRC. The expression of hsa-miR-93-5p remained downregulated after 6 days under combined treatments FOX and FIRI as well as the hsa-miR-17-5p expression under FIRI. Chemotherapy regimens for mCRC increased expression of a major TGF‐β signaling target gene PAI-1, independently of the selected miRNAs expression. These treatments also increased the expression of epithelial-mesenchymal transition (EMT) markers CDH1 and VIM on day 3 resulting in decrease of mesenchymal-like characteristics. However, their expression returned close to basal level on day 6. In conclusion, after initial response to chemotherapeutic drugs SW620 cells start to return close to the basal mesenchymal state while the long-term downregulated expression pattern of hsa-miR-93-5p and hsa-miR-17-5p makes them candidates worth testing as biomarkers for monitoring combined chemotherapeutic treatments therapy response in mCRC patients.
      PubDate: 2021-12-01
       
  • Inhibition of miR-145-5p Reduces Spinal Cord Injury-Induced Inflammatory
           and Oxidative Stress Responses via Affecting Nurr1-TNF-α Signaling Axis

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      Abstract: Inflammation and oxidative stress feature prominently in the secondary spinal cord injury (SCI). The present work is targeted at deciphering miR-145-5p’s role and underlying mechanism in SCI. We randomly divided Sprague-Dawley rats into SCI group and control group. Microglial BV2 cells were separated into control group and lipopolysaccharide (LPS) treatment group. Enzyme-linked immunosorbent assay was carried out for determining the concentrations of interleukin-6, interleukin-1β, and tumor necrosis factor-α (TNF-α). The expressions of malondialdehyde, glutathione peroxidase, superoxide dismutase, and reactive oxygen species were also detected. TNF-α, miR-145-5p, and Nurr1 expressions were examined by western blot and quantitative real-time polymerase chain reaction. Western blotting and dual-luciferase reporter gene assay were conducted to examine the regulating impact that miR-145-5p had on Nurr1 and TNF-α. MiR-145-5p was remarkably upregulated in the SCI rat model’s spinal cord tissues and BV2 cells treated with LPS, and Nurr1 expression was dramatically lowered. Furthermore, miR-145-5p inhibition markedly repressed inflammatory and oxidative stress responses. Moreover, it was proved that Nurr1 was a direct miR-145-5p target. The inhibition of miR-145-5p helped promote Nurr1 expression to block TNF-α signaling. MiR-145-5p inhibition mitigates inflammation and oxidative stress via targeting Nurr1 to regulate TNF-α signaling, which ameliorates SCI.
      PubDate: 2021-12-01
       
  • Abdominal Massage Alleviates Skeletal Muscle Insulin Resistance by
           Regulating the AMPK/SIRT1/PGC-1α Signaling Pathway

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      Abstract: Abdominal massage (AM), a traditional Chinese medicine-based treatment method, has received considerable attention in the recent years. The aim of the present study was to investigate the effect of AM on high-fat diet (HFD)-induced insulin resistance (IR) in comparison with resveratrol (RSV) treatment. Forty-eight male Sprague-Dawley rats were randomly divided into the following four groups: standard chow diet (control group), high-fat diet (model group), HFD + abdominal massage (AM group), and HFD + resveratrol (RSV group). A rat model of IR was established by feeding HFD to rats for 8 weeks followed by treatment with AM or RSV for 4 weeks. The underlying HFD-induced IR molecular mechanisms were studied in rat serum and skeletal muscles. RSV and AM significantly improved glucose intolerance, hyperglycemia, obesity, and significantly reduced lipid accumulation [triglyceride (TC), total cholesterol (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)], adipocytokine [free fatty acids (FFA), adiponectin (ADPN)] and serum pro-inflammatory cytokines (IL-6 and TNF-α) secretion. In addition, AM activated the AMPK/SIRT1 signaling pathway in rat skeletal muscle. In conclusion, our results showed that AM could improve IR by regulating the secretion of adipocytokines, pro-inflammatory cytokines as well as related signaling pathways in the skeletal muscle of rats, which might provide insights into development of new treatment methods for the clinical treatment of IR.
      PubDate: 2021-12-01
       
  • Bioflavonoid (Hesperidin) Restrains Protein Oxidation and Advanced
           Glycation End Product Formation by Targeting AGEs and Glycolytic Enzymes

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      Abstract: Alpha-amylase (α-amylase) not long ago has acquire recognition as a possible drug target for the management of diabetes. Here, we have investigated the binding and enzyme activity of α-amylase by hesperidin; a naturally occurring flavanone having wide therapeutic potential. Hesperidin exerted an inhibitory influence on α-amylase activity with an IC50 value of 16.6 µM. Hesperidin shows a significant binding toward α-amylase with a binding constant (Ka) of the order of 104 M−1. The evaluation of thermodynamic parameters (∆H and ∆S) suggested that van der Waals force and hydrogen bonding drive seemingly specific hesperidin-α-amylase complex formation. Glycation and oxidation studies were performed using human serum albumin (HSA) as ideal protein. Hesperidin inhibited fructosamine content ≈40% at 50 µM and inhibited advanced glycation end products (AGEs) formation by 71.2% at the same concentration. Moreover, significant recovery was evident in free –SH groups and carbonyl content of HSA. Additionally, molecular docking also entrenched in vitro observations and provided an insight into the important residues (Trp58, Gln63, His101, Glu233, Asp300, and His305) at the heart of hesperidin-α-amylase interaction. This study delineates mechanistic insight of hesperidin-α-amylase interaction and provides a platform for use of hesperidin to treat AGEs directed diseases.
      PubDate: 2021-12-01
       
  • Suppression of lncRNA HOXA11-AS/miR-124 Axis Inhibits Glioma Progression

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      Abstract: Our aim was to clarify the regulations of lncRNA HOXA11-AS (HOXA11-AS) played on the progression of glioma as well as to investigate the mechanisms by which HOXA11-AS modulated development of glioma. This study confirmed the regulations of miR-124 and HOXA11-AS on the progression of glioma. Here, HOXA11-AS was overexpressed and miR-124 was underexpressed in glioma. Expression of miR-124 was negatively related to that of HOXA11-AS. Silencing of HOXA11-AS suppressed cell proliferation, invasion, and promoted apoptosis in glioma cells in vitro. Moreover, inhibition of HOXA11-AS expression repressed glioma xenograft tumor growth. Expression of miR-124 was repressed by HOXA11-AS functioning as sponge. In addition, miR-124 knockdown partially abolished the inhibitory roles of HOXA11-AS downregulation in glioma cells. Conclusively, this study suggested that silencing of HOXA11-AS restrained proliferation, invasion, induced apoptosis of glioma cells, and repressed xenograft growth via modulating miR-124 expression and thus inhibited glioma progression.
      PubDate: 2021-12-01
       
  • Advances in Research on Bladder Cancer Targeting Peptides: a Review

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      Abstract: Bladder cancer (Bca) is the second most common malignant tumor of the genitourinary system in Chinese male population with high potential of recurrence and progression. The overall prognosis has not been improved significantly for the past 30 years due to the lack of early theranostic technique. Currently the early theranostic technique for bladder cancer is mainly through the intravesical approach, but the clinical outcomes are poor due to the limited tumor-targeting efficiency. Therefore, the targeting peptides for bladder cancer provide possibility to advance intravesical theranostic technique. However, no systematic review has covered the wide use of the targeting peptides for intravesical theranostic techniques in bladder cancer. Herein, a summary of original researches introduces all aspects of the targeting peptides for bladder cancer, including the peptide screening, the targeting mechanism and its preclinical application.
      PubDate: 2021-09-01
      DOI: 10.1007/s12013-021-01019-3
       
  • Cellular and Molecular Detection of Multi-doses of Ionizing
           Radiation-Induced Immunomodulatory Response

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      Abstract: Ionizing radiation (IR) is used in a wide range of clinical applications. The study aims to evaluate various IR doses for their immunomodulatory responses, which can be used in multiple immunological conditions. Forty rats were exposed to whole-body gamma rays of 0, 0.25, 0.5, and 1 Gray (Gy). T-cell receptor (TCR) gene expression, serum transforming growth factor-beta, interleukin-10 (IL-10), and nitric oxide levels were measured on days 1 and 4 post irradiation. TCR activation occurred only at the genetic level, and radiation raised all measured parameters, even at low doses at α = 0.05 (P < 0.05). Except for IL-10, it shows a nearly 6% (P < 0.05) rise in early response in irradiated groups up to 0.5 Gy. At lower doses, the indirect impacts of IR were as essential as the direct impacts, and they increased over time in most measured parameters due to endogenous releases. They were having an anti-proliferative effect on the immune system. Lastly, a single acute IR dose can raise anti-inflammatory cytokines and anti-proliferative effects in the immune system, avoiding various contraindications associated with immunomodulatory drugs. More information on safety and clinical relevance is needed.
      PubDate: 2021-07-05
      DOI: 10.1007/s12013-021-01017-5
       
  • Static Magnetic Stimulation Induces Changes in the Oxidative Status and
           Cell Viability Parameters in a Primary Culture Model of Astrocytes

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      Abstract: Astrocytes play an important role in the central nervous system function and may contribute to brain plasticity response during static magnetic fields (SMF) brain therapy. However, most studies evaluate SMF stimulation in brain plasticity while few studies evaluate the consequences of SMF at the cellular level. Thus, we here evaluate the effects of SMF at 305 mT (medium-intensity) in a primary culture of healthy/normal cortical astrocytes obtained from neonatal (1 to 2-day-old) Wistar rats. After reaching confluence, cells were daily subjected to SMF stimulation for 5 min, 15 min, 30 min, and 40 min during 7 consecutive days. Oxidative stress parameters, cell cycle, cell viability, and mitochondrial function were analyzed. The antioxidant capacity was reduced in groups stimulated for 5 and 40 min. Although no difference was observed in the enzymatic activity of superoxide dismutase and catalase or the total thiol content, lipid peroxidation was increased in all stimulated groups. The cell cycle was changed after 40 min of SMF stimulation while 15, 30, and 40 min led cells to death by necrosis. Mitochondrial function was reduced after SMF stimulation, although imaging analysis did not reveal substantial changes in the mitochondrial network. Results mainly revealed that SMF compromised healthy astrocytes’ oxidative status and viability. This finding reveals how important is to understand the SMF stimulation at the cellular level since this therapeutic approach has been largely used against neurological and psychiatric diseases.
      PubDate: 2021-06-27
      DOI: 10.1007/s12013-021-01015-7
       
 
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