Subjects -> BIOLOGY (Total: 3268 journals)
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    - BIOENGINEERING (143 journals)
    - BIOLOGY (1548 journals)
    - BIOPHYSICS (53 journals)
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BIOPHYSICS (53 journals)

Showing 1 - 52 of 52 Journals sorted alphabetically
Acta Biochimica et Biophysica Sinica     Hybrid Journal   (Followers: 5)
Advanced NanoBiomed Research     Open Access  
Annual Review of Biophysics     Full-text available via subscription   (Followers: 24)
Archives of Biochemistry and Biophysics     Hybrid Journal   (Followers: 17)
BBA Advances     Open Access   (Followers: 4)
BBA Bioenergetics     Hybrid Journal   (Followers: 5)
BBA Biomembranes     Hybrid Journal   (Followers: 11)
Biochemical and Biophysical Research Communications     Hybrid Journal   (Followers: 17)
Biochemistry and Biophysics Reports     Open Access  
Biochimica et Biophysica Acta (BBA) - General Subjects     Hybrid Journal   (Followers: 12)
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids     Hybrid Journal   (Followers: 6)
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease     Hybrid Journal   (Followers: 12)
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research     Hybrid Journal   (Followers: 10)
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics     Hybrid Journal   (Followers: 11)
Bioinspired, Biomimetic and Nanobiomaterials     Hybrid Journal   (Followers: 3)
Biophysical Chemistry     Hybrid Journal   (Followers: 8)
Biophysical Journal     Hybrid Journal   (Followers: 46)
Biophysical Reports     Open Access   (Followers: 5)
Biophysical Reviews and Letters     Hybrid Journal   (Followers: 5)
Biophysics     Hybrid Journal   (Followers: 8)
Biophysics Reports     Open Access  
BMC Biophysics     Open Access   (Followers: 4)
Cell Biochemistry and Biophysics     Hybrid Journal   (Followers: 6)
Current Topics in Biophysics     Open Access   (Followers: 2)
Doklady Biochemistry and Biophysics     Hybrid Journal   (Followers: 1)
European Biophysics Journal     Hybrid Journal   (Followers: 4)
Food Biophysics     Hybrid Journal   (Followers: 3)
Freshwater Biology     Hybrid Journal   (Followers: 31)
GSTF Journal of BioSciences     Open Access  
IEEE Life Sciences Letters     Hybrid Journal  
IEEE Nanotechnology Express     Hybrid Journal   (Followers: 18)
Indian Journal of Biochemistry and Biophysics (IJBB)     Open Access   (Followers: 3)
International Journal of Biochemistry and Biophysics     Open Access   (Followers: 1)
International Journal of Biophysics     Open Access  
Journal of Biopharmaceutical Statistics     Hybrid Journal   (Followers: 23)
Journal of Biophotonics     Hybrid Journal   (Followers: 1)
Journal of Biophysical Chemistry     Open Access   (Followers: 3)
Journal of Biophysics and Structural Biology     Open Access   (Followers: 2)
Journal of Medicine, Physiology and Biophysics     Open Access  
Journal of Physical Chemistry & Biophysics     Open Access  
Membranes and Membrane Technologies     Full-text available via subscription  
Nanomedicine Research Journal     Open Access  
Nanomedicine: Nanotechnology, Biology and Medicine     Hybrid Journal   (Followers: 5)
Natural Products and Bioprospecting     Open Access   (Followers: 2)
Nature Communications     Open Access   (Followers: 310)
PMC Biophysics     Open Access  
Progress in Biophysics and Molecular Biology     Hybrid Journal   (Followers: 1)
Progress in Physical Geography     Hybrid Journal   (Followers: 11)
Quarterly Reviews of Biophysics     Hybrid Journal   (Followers: 3)
Radiation and Environmental Biophysics     Hybrid Journal   (Followers: 3)
Research & Reviews : A Journal of Life Sciences     Open Access  
Statistics in Biopharmaceutical Research     Full-text available via subscription   (Followers: 15)
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Radiation and Environmental Biophysics
Journal Prestige (SJR): 0.64
Citation Impact (citeScore): 2
Number of Followers: 3  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1432-2099 - ISSN (Online) 0301-634X
Published by Springer-Verlag Homepage  [2537 journals]
  • Co-overexpression of TRAIL and Smac sensitizes MDA-MB-231 cells to
           radiation through apoptosis depending on mitochondrial pathway

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      Abstract: Pro-apoptosis in cancer cells has been proposed as a beneficial therapeutic strategy for potentiating the anticancer effects of radiotherapy. TNF-related apoptosis inducing ligand (TRAIL) and Second mitochondria derived activator of caspase (Smac) can induce cell apoptosis. Herein, we designed a conditionally replicating adenoviral co-overexpression vector of TRAIL and Smac regulated by the Egr1 promoter, in which hTERT, E1A-E1B and E1B55K genes were inserted to achieve enhanced tumor targeting characteristics. After breast cancer MDA-MB-231 cells were infected and irradiated, cellular proliferation and colony formation were measured, apoptotic rate was detected by FCM after AnnexinV-FITC/PI staining. To explore the molecular mechanisms of apoptosis, mRNA and protein levels of TRAIL, Smac, Cytochrome c (Cyt c), death receptor 5 (DR5), caspase-8, -9 and -3 were measured by quantitative real-time PCR, ELISA and Western blot, and caspase-3 activity was detected using caspase-3 activity kits. The results showed that TRAIL and/or Smac overexpression enhanced proliferation inhibition and radio-sensitivity through apoptosis. In addition, the combination of IR and overexpression of TRAIL and/or Smac can activate more apoptosis in tumor cells, and the transcriptional levels and protein expressions of Cyt c, DR5, caspase-8, -9 and -3 had similar regularity with apoptotic changes, indicating the molecular mechanisms of TRAIL and Smac involves the mitochondrial pathway. Our findings may have implications for novel radiotherapy plans for breast tumor treatment.
      PubDate: 2022-01-10
       
  • Visual grading experiments and optimization in CBCT dental implantology
           imaging: preliminary application of integrated visual grading regression

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      Abstract: This study uses a general formulation of integrated visual grading regression (IVGR) and applies it to cone beam computed tomography (CBCT) scan data related to anatomical landmarks for dental implantology. The aim was to assess and predict a minimum acceptable dose for diagnostic imaging and reporting. A skull phantom was imaged with a CBCT unit at various diagnostic exposures. Key anatomical landmarks within the images were independently reviewed by three trained observers. Each provided an overall image quality score. Statistical analysis was carried out to examine the acceptability of the images taken, using an IVGR analysis that was formulized as a three-stage protocol including defining an integrated score, development of an ordinal regression, and investigation of the possibility for dose reduction through estimated parameters. For a unit increase in the logarithm of radiation dose, the odds ratio that the integrated score for an image assessed by observers being rated in a higher category was 3.940 (95% confidence interval: 1.016–15.280). When assessed by the observers, the minimum dose required to achieve a 75% probability for an image to be classified as at least acceptable was 1346.91 mGy·cm2 dose area product (DAP), a 31% reduction compared to the 1962 mGy·cm2 DAP default dosage of the CBCT unit. The kappa values of the intra and inter-observer reliability indicated moderate agreements, while a discrepancy among observers was also identified because each, as expected, perceived visibility differently. The results of this work demonstrate the IVGR’s predictive value of dose saving in the effort to reduce dose to patients while maintaining reportable diagnostic image quality.
      PubDate: 2022-01-05
       
  • Assessment of thoron contribution to indoor radon exposure in Canada

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      Abstract: From 2007 to 2013, simultaneous radon (222Rn) and thoron (220Rn) measurements were conducted in a total of 3534 residential homes in 34 metropolitan areas covering 71% of the Canadian population. While radon levels were above the detector’s detection limit in almost all homes, thoron concentrations were measurable in only 1738 homes. When analysis was limited to homes where thoron concentrations exceeded the detection limit, a pooled analysis confirmed that thoron is log-normally distributed in the indoor environment, and the distribution was characterized by a population-weighted geometric mean of 13 Bq/m3 and a geometric standard deviation of 1.89. Thoron contribution to indoor radon dose varied widely, ranging from 1.3 to 32% geographically. This study indicated that on average, thoron contributes 4% of the radiation dose due to total indoor radon exposure (222Rn and 220Rn) in Canada.
      PubDate: 2022-01-01
       
  • Gold-nanoparticle-enriched breast tissue in breast cancer treatment using
           the INTRABEAM® system: a Monte Carlo study

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      Abstract: Using a 50-kV INTRABEAM® system after breast-conserving surgery, breast skin injury and long treatment time remain the challenging problems when large-size spherical applicators are used. This study has aimed to address these problems using gold (Au) nanoparticles (NPs). For this, surface and isotropic doses were measured using a Gafchromic EBT3 film and a water phantom. The particle propagation code EGSnrc/Epp was used to score the corresponding doses using a geometry similar to that used in the measurements. The simulation was validated using a gamma index of 2%/2 mm acceptance criterion in the gamma analysis. After validation Au-NP-enriched breast tissue was simulated to quantify any breast skin dose reduction and shortening of treatment time. It turned out that the gamma value deduced for validation of the simulation was in an acceptable range (i.e., less than one). For 20 mg-Au/g-breast tissue, the calculated Dose Enhancement Ratio (DER) of the breast skin was 0.412 and 0.414 using applicators with diameters of 1.5 cm and 5 cm, respectively. The corresponding treatment times were shortened by 72.22% and 72.30% at 20 mg-Au/g-breast tissue concentration, respectively. It is concluded that Au-NP-enriched breast tissue shows significant advantages, such as reducing the radiation dose received by the breast skin as well as shortening the treatment time. Additionally, the DERs were not significantly dependent on the size of the applicators.
      PubDate: 2021-12-03
       
  • Correction to: Genomic instability induced by radiation-mimicking
           chemicals is not associated with persistent mitochondrial degeneration

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      PubDate: 2021-12-02
       
  • Epidemiology of stroke and transient ischemic attacks in the population of
           the territories adjacent to the former Semipalatinsk Nuclear Test Site,
           Kazakhstan

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      Abstract: The issue of radiation exposure as a potential cause of cerebrovascular disease raises many concerns. The aim of the present study was to investigate the epidemiology of stroke and transient ischemic attacks (TIA) along with the associated risk factors among the population of East Kazakhstan exposed to ionising radiation from the former Semipalatinsk Nuclear Test Site (SNTS) in comparison with the unexposed population of the same region. This 5-year retrospective cross-sectional study included the data on 10,970 patients, of whom the majority (62.3%) suffered from ischemic stroke, 11.7% had hemorrhagic stroke and the remaining 26.0% had TIA. At the moment when stroke/TIA happened, exposed patients were younger than the unexposed (mean age 63 years versus 64 years, p < 0.001) and showed higher rates of nearly all associated comorbidities, which commonly were more severe. Besides, exposed patients showed a higher risk of stroke lethality in contrast with the unexposed. The observed features might indicate that people residing in the vicinity of the SNTS are vulnerable to cerebrovascular disease and thus, this study contributes to timely recognition of this public health problem. In addition, a longitudinal study has to be envisaged to clarify whether there is any cause-effect relationship between exposure to radiation from the SNTS and the development of stroke or transient ischemic attacks.
      PubDate: 2021-11-25
       
  • External dose reconstruction at the shore of the Metlinsky Pond in the
           former village of Metlino (Techa River, Russia) based on environmental
           surveys, luminescence measurements and radiation transport modelling

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      Abstract: The cohorts of people formerly living at the Techa River shoreline in the Southern Urals, Russia, are widely studied cohorts for the investigation of low-dose radiation effects to human health. The nuclear facilities of the Mayak Production Association (PA) discharged their radioactive effluents into the nearby Techa River, especially in the first years of operation. Health status of cohort member data is constantly being improved and updated. Consequently, there is a need to also improve and verify the underlying dosimetry, which gives information about the dose of cohort members. For the Techa River population, the dosimetry is handled in the Techa River Dosimetry System (TRDS). The present work shows results of a feasibility study to validate the TRDS at the location of the village of Metlino, a village just 7 km downstream from the Mayak PA. For this settlement there were two sources of external exposure, the contaminated banks of the Techa River and the contaminated shoreline of the nearby Metlinsky Pond. In the present study the north-western wall of a granary was used as a dose archive to validate dose estimates. Measurements of doses in brick accumulated over many decades and measurements of the current dose rate in bricks were combined with dose rate measurements in air above ground in front of the granary, historical contamination data and Monte-Carlo simulations. Air kerma estimates for 1949–1956 significantly different from zero could not be reconstructed for the Metlinsky Pond shoreline near the granary, but an upper dose limit could be estimated. Implications for TRDS-2016 are discussed.
      PubDate: 2021-11-24
       
  • Chinese hamster V79 cells’ dependence on background ionizing
           radiation for optimal growth

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      Abstract: The study of depriving cells from background ionizing radiation for the past decades has provided valuable insights into its role in cellular homeostasis control. To explore the existence of such response in eukaryotic cells, we grew Chinese hamster (Cricetulus griseus) V79 cells for 23 days using three different dose rates: 0.91 (below background), 35 (surface control) and 72 nGy h−1 (underground KCl-amended control). We did not observe a significant difference in cell number during the course of the experiment. However, cells grown at below background showed significantly lower viability compared to those grown at both control levels after 5 days of incubation and lasted, intermittently, for up to 21 days. We also observed a clear differentiation between the underground and the surface controls that could be explained by the variety of radiation sources present during cell growth under unshielded conditions. To explore the molecular mechanisms for these responses we performed transcriptome analysis on samples collected on days 2 and 5, but only samples from day 5 resulted in significant regulation. Gene enrichment analysis revealed two control-dependent general transcriptional responses. When compared the underground-KCl control, below-background cells showed the upregulation of processes intended for the response to drugs, metals and mechanical stimuli. In comparison, the response relative to the surface control was characterized by the upregulation of responses to organic substances and abiotic stimuli involved in the regulation of signaling, as well as to cell proliferation and homeostatic control of the number of cell processes.
      PubDate: 2021-11-09
       
  • Radiological protection revisited—the story continues

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      PubDate: 2021-11-01
       
  • Correction to: In vitro cellular and proteome assays identify Wnt pathway
           and CDKN2A-regulated senescence affected in mesenchymal stem cells from
           mice after a chronic LD gamma irradiation in utero

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      PubDate: 2021-10-02
      DOI: 10.1007/s00411-021-00945-3
       
  • Reply and explanation to Little et al. “Response to: On the choice of
           methodology for evaluating dose‑rate effects on radiation‑related
           cancer risks”

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      PubDate: 2021-09-30
      DOI: 10.1007/s00411-021-00944-4
       
  • Correction to: Cancer risk from chronic exposures to chemicals and
           radiation: a comparison of the toxicological reference value with the
           radiation detriment

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      PubDate: 2021-09-28
      DOI: 10.1007/s00411-021-00943-5
       
  • Voxel model of a rabbit: assessment of absorbed doses in organs after CT
           examination performed by two different protocols

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      Abstract: The objective of this work was to assess absorbed doses in organs and tissues of a rabbit, following computed tomography (CT) examinations, using a dedicated 3D voxel model. Absorbed doses in relevant organs were calculated using the MCNP5 Monte Carlo software. Calculations were perfomed for two standard CT protocols, using tube voltages of 110 kVp and 130 kVp. Absorbed doses were calculated in 11 organs and tissues, i.e., skin, bones, brain, muscles, heart, lungs, liver, spleen, kidney, testicles, and fat tissue. The doses ranged from 15.3 to 28.3 mGy, and from 40.2 to 74.3 mGy, in the two investigated protocols. The organs that received the highest dose were bones and kidneys. In contrast, brain and spleen were organs that received the smallest doses. Doses in organs which are stretched along the body did not change significantly with distance. On the other hand, doses in organs which are localized in the body showed maximums and minimums. Using the voxel model, it is possible to calculate the dose distribution in the rabbit’s body after CT scans, and study the potential biological effects of CT doses in certain organs. The voxel model presented in this work can be used to calculated doses in all radiation experiments in which rabbits are used as experimental animals.
      PubDate: 2021-09-06
      DOI: 10.1007/s00411-021-00941-7
       
  • Comments and suggestions on fundamental principles of radiation protection

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      PubDate: 2021-09-01
      DOI: 10.1007/s00411-021-00937-3
       
  • Virtual Igor: an analytical phantom for the simulation of the Saint
           Petersburg brick phantom in arbitrary layouts in MCNP

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      Abstract: A computer code called Virtual Igor is presented. The code generates an analytical representation of the Saint Petersburg brick phantom family (Igor, Olga, Irina), which is frequently used for the calibration of whole-body counters, in arbitrary user-defined layouts for the use in the Monte-Carlo radiation transport code MCNP. The computer code reads a file in the ldraw format, which can easily be produced by simple freeware software with graphical user interfaces and which contains the types and coordinates of the bricks. Ldraw files with the canonical layouts of the brick phantom are provided with Virtual Igor. The code determines the positions of (2.75 cm)3 segments of the bricks, where 2.75 cm is the smallest length in the layout and, therefore, represents the spacing of the segment lattice. Each segment contains the exact geometry of the respective part of the brick, using cuboid and cylindrical surfaces. The user can define which rod source drill holes of which bricks contain the rod-type radionuclide sources. The method facilitates the comparison of different layouts of the Saint Petersburg brick phantom with each other and with anthropomorphic computational phantoms.
      PubDate: 2021-08-28
      DOI: 10.1007/s00411-021-00939-1
       
  • Obituary Prof. Dr. Wolfgang Weiss (1946–2021)

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      PubDate: 2021-08-23
      DOI: 10.1007/s00411-021-00932-8
       
  • Response to “On the choice of methodology for evaluating dose-rate
           effects on radiation-related cancer risks” by Walsh et al.

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      PubDate: 2021-08-17
      DOI: 10.1007/s00411-021-00935-5
       
  • A Monte Carlo study to investigate the feasibility to use the Moroccan
           panoramic irradiator in sterile insect technique programs

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      Abstract: Mediterranean fly pest (Ceratitis) is one of the most destructive pests of fruit species in Morocco. The sterile insect technique (SIT) is an environmentally friendly strategy that uses ionizing radiation to sterilize adult insects. Morocco has a panoramic gamma irradiator used to irradiate agri-food products. This irradiator is not dedicated to SIT programs due to its geometry that does not allow to obtain a dose uniformity ratio (DUR) recommended for such applications. This article presents a Monte Carlo study to investigate the feasibility of using the panoramic gamma irradiator at the National Institute for Agronomic Research (NIAR) of Tangier, Morocco, to setting up SIT methods and contributing to Ceratitis control programs. The Monte Carlo method was used to simulate the concrete bunker in which the panoramic gamma irradiator is installed. To obtain a recommended DUR required for SIT programs, two cells similar of the Gammacell-220 irradiator, which is mainly used in the SIT programs around the world, were simulated inside the concrete bunker. The simulation and calculations were performed using the MCNPX-2.7e Monte Carlo simulation code. It is demonstrated that at both investigated positions, the spatial distribution of dose rates in the two modeled irradiation cells, which were similar to a gammacell-220 irradiator cell, are uniform enough that the cells can be used for SIT programs. It is concluded that the panoramic irradiator at NIAR can be used to contribute to the control of Mediterranean fly pest and other insect pests in Morocco.
      PubDate: 2021-08-14
      DOI: 10.1007/s00411-021-00934-6
       
  • Dosimetric study of a hybrid plan technique for external beam radiotherapy
           in patients with cervical cancer

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      Abstract: The aim of this study was to investigate the effect of a hybrid technique which results from combining intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) for the treatment of cervical cancer patients. Plans made with the hybrid technique and pure IMRT and VMAT were retrospectively compared in 20 patients with cervical cancer at different stages. All plans were made using the same contours based on the original computed tomography (CT) scans. Conformity (CI) and homogeneity (HI) indices of the planning target volumes (PTVs) were calculated for each technique in order to evaluate plan quality. All techniques were compared in terms of dose to organs at risk (OARs), number of monitor units (MUs) and treatment time. It turned out that plans made with the hybrid technique had improved dose conformity and homogeneity compared to plans made only with IMRT and VMAT (p < 0.001). Regarding the OARs, the maximum dose (Dmax) delivered to the bladder, rectum and femoral heads was lower for the hybrid plans compared to the IMRT and VMAT plans (p < 0.001). The volumes irradiated to doses of 50 Gy (V50Gy) for rectum, bladder and bowel were lower for the hybrid plans (p < 0.001, p = 0.002). Furthermore, the treatment time and MU values for the hybrid plans were found to be between of the values for the IMRT and VMAT plans. It is concluded that, as compared to IMRT and VMAT plans, the hybrid plan technique allowed a better conformity and homogeneity for the dose distribution in the PTV and a dose reduction to the OARs.
      PubDate: 2021-08-06
      DOI: 10.1007/s00411-021-00931-9
       
  • Synthesis and evaluation of thermoluminescence properties of ZrO2:Mg for
           radiotherapy dosimetry

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      Abstract: This study aimed to investigate the thermoluminescent properties of ZrO2:Mg irradiated with a 6 MV X-ray beam and its potential application in radiotherapy dosimetry. ZrO2 powder was synthesized using the sol–gel method and Mg was used as a dopant. Irradiations were performed with ZrO2:Mg chips located at the center of a 10 × 10 cm2 radiation field at a source surface distance of 100 cm, below a stack of solid water slabs, at the depth of maximum absorbed dose. The investigated characteristics of the material included linearity with radiation dose, reproducibility, accuracy, sensitivity and fading. Regarding the intrinsic difference of the samples, the glow curves of the investigated ZrO2:Mg chips exposed to 1 Gy of 6 MV X-rays exhibited three or four peaks. The ZrO2:Mg samples showed a 47% fading at 24 h after irradiation, and the reproducibility of the thermoluminescence reading of ZrO2:Mg for equal irradiation conditions was ± 21%. The thermoluminescence response of the investigated ZrO2:Mg samples to various absorbed doses from 0.5 to 2.5 Gy showed a gentle increase of the thermoluminescence intensity with increasing absorbed dose. The obtained results show that ZrO2:Mg is not an appropriate candidate for X-ray photons in radiotherapy, due to low thermoluminescence peak temperature, low reproducibility, low sensitivity to various absorbed doses and significant fading.
      PubDate: 2021-08-04
      DOI: 10.1007/s00411-021-00928-4
       
 
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