Subjects -> BIOLOGY (Total: 3134 journals)
    - BIOCHEMISTRY (239 journals)
    - BIOENGINEERING (143 journals)
    - BIOLOGY (1491 journals)
    - BIOPHYSICS (53 journals)
    - BIOTECHNOLOGY (243 journals)
    - BOTANY (220 journals)
    - CYTOLOGY AND HISTOLOGY (32 journals)
    - ENTOMOLOGY (67 journals)
    - GENETICS (152 journals)
    - MICROBIOLOGY (265 journals)
    - MICROSCOPY (13 journals)
    - ORNITHOLOGY (26 journals)
    - PHYSIOLOGY (73 journals)
    - ZOOLOGY (117 journals)

BIOPHYSICS (53 journals)

Showing 1 - 43 of 43 Journals sorted alphabetically
Acta Biochimica et Biophysica Sinica     Hybrid Journal   (Followers: 5)
Advanced NanoBiomed Research     Open Access   (Followers: 1)
Archives of Biochemistry and Biophysics     Hybrid Journal   (Followers: 11)
BBA Advances     Open Access   (Followers: 2)
BBA Bioenergetics     Hybrid Journal   (Followers: 4)
BBA Biomembranes     Hybrid Journal   (Followers: 10)
Biochemical and Biophysical Research Communications     Hybrid Journal   (Followers: 10)
Biochemistry and Biophysics Reports     Open Access   (Followers: 1)
Biochimica et Biophysica Acta (BBA) - General Subjects     Hybrid Journal   (Followers: 9)
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids     Hybrid Journal   (Followers: 6)
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease     Hybrid Journal   (Followers: 6)
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research     Hybrid Journal   (Followers: 8)
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics     Hybrid Journal   (Followers: 6)
Bioinspired, Biomimetic and Nanobiomaterials     Hybrid Journal   (Followers: 3)
Biophysical Chemistry     Hybrid Journal   (Followers: 7)
Biophysical Journal     Hybrid Journal   (Followers: 50)
Biophysical Reports     Open Access   (Followers: 4)
Biophysical Reviews and Letters     Hybrid Journal   (Followers: 6)
Biophysics     Hybrid Journal   (Followers: 10)
Biophysics Reports     Open Access  
Cell Biochemistry and Biophysics     Hybrid Journal   (Followers: 9)
Doklady Biochemistry and Biophysics     Hybrid Journal   (Followers: 1)
European Biophysics Journal     Hybrid Journal   (Followers: 4)
Food Biophysics     Hybrid Journal   (Followers: 2)
Freshwater Biology     Hybrid Journal   (Followers: 34)
GSTF Journal of BioSciences     Open Access   (Followers: 1)
IEEE Life Sciences Letters     Hybrid Journal  
IEEE Nanotechnology Express     Hybrid Journal   (Followers: 16)
International Journal of Biochemistry and Biophysics     Open Access   (Followers: 1)
International Journal of Biophysics     Open Access  
Journal of Biopharmaceutical Statistics     Hybrid Journal   (Followers: 17)
Journal of Biophotonics     Hybrid Journal   (Followers: 1)
Journal of Biophysical Chemistry     Open Access   (Followers: 5)
Journal of Biophysics and Structural Biology     Open Access   (Followers: 5)
Membranes and Membrane Technologies     Full-text available via subscription  
Nanomedicine: Nanotechnology, Biology and Medicine     Hybrid Journal   (Followers: 5)
Natural Products and Bioprospecting     Open Access   (Followers: 2)
Nature Communications     Open Access   (Followers: 508)
Progress in Biophysics and Molecular Biology     Hybrid Journal   (Followers: 1)
Progress in Physical Geography     Hybrid Journal   (Followers: 13)
Quarterly Reviews of Biophysics     Hybrid Journal   (Followers: 2)
Radiation and Environmental Biophysics     Hybrid Journal   (Followers: 3)
Statistics in Biopharmaceutical Research     Full-text available via subscription   (Followers: 10)
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Biophysics
Journal Prestige (SJR): 0.216
Number of Followers: 10  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1555-6654 - ISSN (Online) 0006-3509
Published by Springer-Verlag Homepage  [2468 journals]
  • Chlorophyllin Inhibits Lipid Peroxidation Triggered by the Fenton Reaction

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      Abstract: Abstract Using the Fenton reaction, a system has been modeled in which particles similar to those formed during the radiolysis of water were generated. The suppression of reactions caused by hydroxyl radicals formed in the system under the action of chlorophyllin is evaluated by the chemiluminescence method. It has been shown that sodium-copper chlorophyllin dose-dependently inhibits the chemiluminescence accompanying the phosphatidic acid peroxidation induced by the Fenton reaction. Based on this, it is concluded that copper chlorophyllin can inhibit the metabolism of lipid radiotoxins, lipid peroxidation (LP), caused by the attack of water radiolysis products on lipid molecules.
      PubDate: 2024-02-01
       
  • Spatial Structure of the Casoxin C Molecule

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      Abstract: Abstract A theoretical conformational analysis was performed to study the conformational possibilities for the casoxin C molecule (Tyr1–Ile2–Pro3–Ile4–Gln5–Tyr6–Val7–Leu8–Ser9–Arg10–OH). The potential function of the system was chosen as a sum of non-valence, electrostatic, and torsion interactions, and the energy of hydrogen bonds. The low-energy conformations of the casoxin C molecule were found, the values of dihedral angles of the main and side chains of the amino acid residues that make up the molecule were determined, and the energy of intra- and interresidual interactions was estimated. It has been shown that the spatial structure of the casoxin C molecule is represented by conformations of eight shapes of the peptide backbone. The results obtained can be used to elucidate the structural and structural-functional organization of casoxin molecules.
      PubDate: 2024-02-01
       
  • Patterns of Purinergic Modulation of Myoneural Transmission in Presence of
           Capsaicin

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      Abstract: Abstract This study aimed to investigate myoneural transmission in the presence of capsaicin, which acts as an integrator of pain stimuli and causes heat sensation. The effects of purines that participate in synaptic transmission, such as ATP and adenosine, in the presence of capsaicin were explored. When the neuromuscular preparation of frog was perfused with solution containing capsaicin, the inhibitory effects of both purines were significantly reduced. A reduction of the depressant effects of adenosine is associated with the inhibition of A1 signaling, since the A2A receptor agonist CGS21680 showed a pronounced potentiating effect in the presence of capsaicin, which was almost completely hidden in the control. Our findings suggest that the known neuroprotective effect of capsaicin is primarily due to elimination of inhibition by endogenous purines of the induced quantum output of the neurotransmitter.
      PubDate: 2024-02-01
       
  • Differential Scanning Calorimetry of Edible Plant-Based Protein Using
           Glycerol as a Medium

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      Abstract: Abstract Plant-based protein isolates are common food ingredients. Differential scanning calorimetry of isolates is used to predict their functional properties, as well as to evaluate the propensity of these isolates to form bioplastics through the heat-induced formation of intermolecular disulfide, hydrophobic, and other types of bonds. In this study, we use differential scanning calorimetry of a suspension containing a soy protein isolate (SPI) in glycerol. It is shown that heat is released upon heating the isolate in the presence of glycerol. The preliminary thermal denaturation of a water solution of soy proteins (95°C, 30 min) increases the thermal effect, while the enzymatic hydrolysis of the protein leads to a loss of the exothermic thermal effect. The addition of β-mercaptoethanol to the SPI has no effect on the observed exothermic process, which indicates the absence of a contribution of the formation of new disulfide bonds in this case. Thus, the formation of bioplastic by an SPI does not depend on the formation of new disulfide bonds, and the use of the differential scanning calorimetry method can be considered as a method for estimating the solubility of the protein preparation.
      PubDate: 2024-02-01
       
  • Secondary Metabolites and Amino Acids in the Neocortex of the Long-Tailed
           Ground Squirrel Urocitellus undulatus at Different Stages of Hibernation

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      Abstract: Abstract This study continues our previous research aimed at investigating changes in the pools of amino acids in the myocardium of the ground squirrel during winter torpor. Neurochemical profiles of amino acids and the secondary metabolites (taurine, phosphoserine, and cysteic acid) were explored in the neocortex of the ground squirrel at different stages of torpor: in the beginning of torpor (2–3 days) and during prolonged torpor (9–10 days), as well as during short-term winter arousal (winter activity, euthermia). Reduced excitatory neurotransmitter levels (glutamate by 7% and 14%; aspartate by 25% and 52% in a coordinated manner and the increased level of GABA, the main transmission inhibitor (by 50% and 67%) were observed from the onset of the torpor entry and at the end of the torpor arousal, respectively. Alanine, which was formed in negligible amounts in the neocortex in the summer season, increased at the initial stage of hibernation and after multiday torpor bout (by 98% and 126%, respectively), indicating a partial switch to anaerobic glycolysis. Short-term interbout euthermia returned levels of these substances back to normal. The behavior of glutamate and aspartate, the anaplerotic substrates, that supported cycling of the tricarboxylic acid cycle during torpor and winter activity periods was like their responses in the myocardium, though differed quantitatively. The responses of the neuromodulators such as glycine, threonine, and lysine differed radically when compared to their responses in the myocardium. No changes in taurine and phosphoserine pools were detected, but the level of cysteic acid decreased compared to the summer control from 0.51 ± 0.06 μmol/g to 0.07 ± 0.01 μmol/g at the end of torpor, while during winter euthermia it became 2 times lower than the summer level. Our data suggest that metabolic pathways involving anaplerotic amino acids of the neocortex are more active than the myocardium during winter torpor, while the pools of neuromodulators that regulate inhibition processes, increase.
      PubDate: 2024-02-01
       
  • Fluctuation Dielectric Fourier Spectrometer and Rapid Evaluation of Blood
           Cell Characteristics

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      Abstract: Abstract A method for assessing the state of formed elements based on the dielectric characteristics of a blood suspension is considered. A design of a fluctuation dielectric Fourier spectrometer (FDFS) is proposed, with the help of which it is possible to estimate the distribution of the formed blood elements according to their membrane state. As an illustration, experiments to assess the functional state of patients with coronary heart disease and an experiment on the effect of ascitic Ehrlich carcinoma on laboratory mice are described. It is shown that by using the proposed spectrometer, it is possible to obtain express estimates of changes in blood characteristics during diseases and to identify the dynamics of pathological processes in animals with ascitic Ehrlich carcinoma.
      PubDate: 2024-02-01
       
  • Content of Nitrogen Monoxide and Copper in the Hippocampus of a Rat Model
           of Short-Term Cerebral Ischemia Followed by Reperfusion

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      Abstract: Abstract Electron paramagnetic resonance (EPR) spectroscopy is used to determine the content of nitric oxide (NO) and copper in the hippocampus of healthy rats and rats under ischemia modeling. Ischemia is modeled by both carotid artery ligation and carotid artery ligation, followed by taking 3 mL of blood from the common carotid artery. Signals from (DETC)2-Fe2+-NO and Cu(DETC)2 complexes are recorded by EPR spectroscopy. A significant decrease in NO production in the hippocampus (on average 28% per day) is found after an ischemic stroke caused by carotid artery ligation; and by 56% after carotid artery ligation followed by 3 mL of blood taken from the common carotid artery. The copper content in the hippocampus the day after ischemia caused by carotid artery ligation significantly decreases by an average of 20%; after carotid artery ligation with blood sampling, there is a tendency for the copper content to decrease; however, due to the large scatter of values, the reliability of the changes cannot be confirmed. Thus, cerebral hypoxia caused by carotid artery ligation is accompanied by a decrease in NO production in the hippocampus and signs of weakening of the antioxidant system, which further harmed the functional state of the homeostasis system.
      PubDate: 2024-02-01
       
  • Antitumor and Cytotoxic Effect of Silver Polyacrylate

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      Abstract: Abstract Silver polyacrylate (argacryl) is shown to have antitumor activity in models of solid mouse tumors in vivo and a cytotoxic effect on human tumor cells in vitro. Argacryl enhances the antitumor effect of cisplatin (Lewis lung carcinoma in mice) and does not show cross resistance with cisplatin and doxorubicin (human breast cancer MCF-7). The molecular mechanism of action of argacryl could be associated with the induction of single-strand DNA breaks in the absence of crosslinking in the DNA molecule.
      PubDate: 2024-02-01
       
  • Low-frequency Oscillations of Functional Indicators of the Body

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      Abstract: Abstract It has been shown in a number of our studies that low-frequency (LF) oscillations in the functional parameters of the oxygen transport system are stable and synchronized with each other. The literature presents a large number of examples of LF oscillations of various functional indicators that are directly or indirectly related to energy metabolism. In parallel, for more than 40 years, artificially induced attenuated and constant spontaneous oscillations in the energization levels of mitochondria in the same LF range have been studied. The aim of this review is to consider a possible relationship between oscillations in the functional parameters of the oxygen transport system and the functional parameters of mitochondria in the very-low-frequency (VLF) range common to them (0.003–0.03 Hz). We believe that a common source for all these oscillations is the periodic dynamics of “energization” in mitochondria united in mitochondrial networks. The process of generating these oscillations proceeds in two phases. In the first phase, the inflow of Ca2+ into the mitochondria exceeds the outflow and enhances the activity of oxidative phosphorylation. In the second phase, the outflow of Ca2+ from the mitochondria prevails over the inflow and is accompanied by the inhibition of oxidative phosphorylation. The oscillations are of a constant spontaneous nature and are based on autocatalytic regulation based on the feedback principle. The inertia of the full cycle processes (first and second phases) lasting 1–3 min may be due to the capacity of the mitochondrial phosphate buffer. The mitochondrial networks of excitable tissues can be the structural basis for synchronizing oscillations at the tissue level. Synchronization at the body level between mitochondrial oscillations and oscillations in indicators related to energy metabolism can be carried out through a system of tunneling nanotubes.
      PubDate: 2024-02-01
       
  • Identification of Two QTLs Controlling Flax Resistance to Fusarium Wilt

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      Abstract: Abstract A bulk segregant analysis (BSA) was used to analyze the F2 population from crossing two flax varieties that differ in fusarium wilt resistance genes. The causative agent of this disease, the fungus Fusarium oxysporum f. sp. lini is one of the main pathogens of flax, causing huge economic damage to its global production. Sequencing of DNA pools of highly resistant and sensitive to fusarium wilt F2 plants and their subsequent analysis identified two regions on chromosomes 9 and 13 that caused resistance to fusarium wilt. Candidate genes for subsequent analysis are selected by functional gene annotation and analysis of gene expression of QTL regions in the transcriptomic data obtained as a result of the infection of the fusarium-resistant Atalante variety. As a result of combining the two approaches, three genes are identified in each of the QTL regions, which, according to the published data, are involved in the plant’s response to infection and are differentially expressed in the transcriptome experiment.
      PubDate: 2024-02-01
       
  • Superoxide Generating Activity of Nicotinamide Coenzymes

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      Abstract: Abstract It has been shown that nicotinamide coenzymes (NADPH, NADH, NADP+, and NAD+) are capable of generating superoxide anions ( \({\text{O}}_{2}^{{ - \,\bullet }}\) ) in an alkaline environment. The superoxide-generating activity of the coenzymes is associated with high pH values and is sensitive to SOD. However, nicotinamide itself, being a functional part of coenzyme molecules, does not have this property. Polarographic studies showed that in the presence of coenzymes, molecular oxygen is consumed from the buffer, namely oxygen activation occurs due to the formation of \({\text{O}}_{2}^{{ - \,\bullet }}\) . Based on the obtained results and in accordance with the literature, our observations suggest that the formation of adducts of nicotinamide, which is part of the coenzyme molecule, and hydroxyl anions (OH–) may lead to the formation of \({\text{O}}_{2}^{{ - \,\bullet }}\) . Under mild conditions in the organism, the studied coenzymes, while performing their main functions, are expected to generate superoxide, meaning that they can be signaling molecules.
      PubDate: 2024-02-01
       
  • Astaxanthin Prevents Dysregulation of Mitochondrial Dynamics in Rat Brain
           Mitochondria Induced by Isoproterenol

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      Abstract: Abstract Mitochondria are involved in diseases of various etiologies. The use of drugs aimed at improving the functional state of mitochondria may be a promising therapeutic approach to diseases of various etiologies. Astaxanthin is a keto-carotenoid (xanthophyll) of predominantly marine origin. It has both lipophilic and hydrophilic properties and can penetrate through the cell membrane, localizing in the mitochondria and preventing mitochondrial dysfunction. In this paper, the effect of astaxanthin on the functional state of rat brain mitochondria, changes in mitochondrial dynamics and mitophagy in isoproterenol-induced damage is studied. Under the action of astaxanthin, mitochondria are more resistant to the Ca2+-induced opening of a nonspecific pore and the activity of complexes I, IV, and V of the respiratory chain increases. Moreover, astaxanthin alters the level of markers of mitochondrial fission and fusion, as well as mitophagy in isoproterenol-induced mitochondrial dysfunction, which probably leads to an increase in the number of functional mitochondria of the rat brain and improved their condition. Astaxanthin can be considered as a mitochondria-directed agent in the therapy for pathological conditions associated with oxidative damage and mitochondrial dysfunction caused by heart failure. As a dietary supplement, astaxanthin has the potential for the antioxidant protection of cells in cardiovascular diseases.
      PubDate: 2024-02-01
       
  • Effect of the Pulsating Flow of Cerebrospinal Fluid on Spinal Pathologies

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      Abstract: Abstract Based on a dynamic parameter of the cerebrospinal fluid (CSF) flow, an original formula for estimating the pathology of the spinal motion segments of the spine is given. The graphs that clearly demonstrate a change in pathology depending on the depth of traumatization are given. The data obtained will be useful to specialists in computed tomography and magnetic resonance imaging, who are currently describing the pathology itself in a simplified way.
      PubDate: 2024-02-01
       
  • Physical Parameters of Arterial Thrombus as a Porous Medium

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      Abstract: Abstract The formation of a hemostatic thrombus is a key response of the hemostatic system to a wide range of possible vascular damage. The main mechanism of thrombus growth in conditions of high shear rates is platelet adhesion and aggregation. It is known that arterial thrombi have significant spatial heterogeneity, which is associated with the heterogeneity of the distribution of platelet activators in the thrombus structure. The spatiotemporal dynamics of the molecules involved in thrombosis depends on the parameters of the transfer of these substances in the thrombus. To study the dynamics of arterial blood thrombi formation, continuum models representing a blood thrombus as a porous medium are actively used today. However, when choosing the parameters of such models, researchers face significant uncertainty caused by conflicting experimental data. This review analyzes the published data on the physical parameters of an arterial thrombus as a porous medium. Special attention is paid to the analysis of parameters for the external part of the thrombus, the so-called shell, which is generally characterized by higher values of porosity and permeability.
      PubDate: 2024-02-01
       
  • Electrogenesis in the Root Environment of Various Lettuce Varieties

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      Abstract: Abstract Bioelectrochemical systems based on electroactive processes in the root environment of plants are a promising direction for the combined production of green electricity and plant products. The dynamics of the electric potential differences formation in the root environment, diffuse reflection indices, fluorescence parameters of leaves, and morphometric and biochemical characteristics of lettuce varieties Chinese curly, Chinese red-green, Ballet, Cocarde, Mercury, Dubrava, Robin, and Solos F1 hybrid are studied. The maximum electric potential difference of 430 mV was typical for the Mercury variety, and the minimum of 352 mV for the Chinese Curly variety. According to the sum of the parameters, in addition to the electrical ones, including the morphometric, biochemical, and photosynthetic characteristics, the lettuce Ballet variety was the best. In the future, based on the data obtained, it will be possible to create agrophytocenoses, including plants capable of high and stable electricity generation together with high productivity and good quality of the plant products obtained, due to the effective assimilation and conversion of light energy.
      PubDate: 2024-02-01
       
  • Morphometric Analysis of Serotoninergic Structures in the Nervous System
           of the Planarian Schmidtea mediterranea

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      Abstract: Abstract The planarian nervous system is represented by a cephalic ganglion in the anterior part of the body and a pair of well-defined ventral nerve trunks extending along the entire body of the animal. The serotoninergic components of the nervous system are determined by the indirect immunocytochemical staining of the total preparations of the planarian Schmidtea mediterranea tissues, followed by analysis by fluorescent microscopy. The presence of serotoninergic components is found in the central and peripheral parts of the nervous system of the planarian S. mediterranea. The morphological parameters of serotonin-immunopositive structures are measured and the number of neurons in the cerebral ganglion is counted. The measurements are carried out on micrographs from stained total preparations obtained using a digital camera. The size of serotonin neurons in three areas of the body, the thickness of nerve trunks and cerebral ganglion, and the distance between nerve trunks and commissures are considered. For the first time, new quantitative data characterizing the morphological properties of the nervous system of the planarian S. mediterranea have been obtained. The regeneration of planarian eyes after decapitation and serotonin exposure is also studied. It is found that exogenous serotonin at a concentration of 0.01–1 μM accelerated eye differentiation during regeneration of the head end of S. mediterranea.
      PubDate: 2024-02-01
       
  • Hafnium Complexes as Contrast Media and Dose Enhancing Agents for
           Radiology and Contrast-Enhanced Radiotherapy

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      Abstract: Hafnium is a promising element as contrast agent for diagnostic and therapeutic radiology. Currently there are no suitable hafnium drugs with renal excretion which can be used in radiology. In this work two new hafnium complexes with nitrilotriacetic acid (Hf-NTA) and 1,2-diaminocyclohexanetetraacetic acid (Hf-CDTA) were synthesized and studied for acute toxicity and biodistribution. Inorganic chemistry methods were used for Hf-NTA and Hf-CDTA synthesis. Acute toxicity was studied in female mice C57Bl/6. Median lethal dose (LD50) of Hf-CDTA was assessed as 408 ± 64 mg Hf/kg and of Hf-NTA less than 120 mg Hf/kg. Biodistribution and contrast properties studies of Hf-CDTA were performed in vivo using micro-CT in mice with transplanted subcutaneous mammary adenocarcinoma Ca755. CT imaging of mice intravenously injected with Hf-CDTA confirmed its renal excretion and contrast capability. CT imaging of tumor region with single intratumoral administration of Hf-CDTA showed promising hafnium concentration and retention in tumor for use in contrast-enhanced radiotherapy. Hf-CDTA showed acceptable toxicity and biodistribution in mice with subcutaneous tumors for biomedical application in radiology and radiotherapy. For diagnostic clinical application, the Hf-CDTA formulation must be improved to increase water solubility and decrease toxicity. Hf-NTA appeared to be unacceptably toxic for radiological application.
      PubDate: 2024-02-01
       
  • Annotation of a New Low-Threshold Potential-Dependent Calcium Channel of
           Trichoplax adhaerens (Phylum Placozoa)

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      Abstract: Abstract The study of potential-dependent calcium channels sheds light on the formation of systems responsible for the coupling of sensors and actuators in a living cell. Based on data on the potential-sensitive calcium channel TCav3 (2063 amino acid residues) from Trichoplax adhaerens cells, homologues of 2090 amino acid residues in the scaffold of Trichoplax sp. H2 and an incomplete polypeptide with a length of 1510 amino acid residues in the scaffold of Trichoplax adhaerens are identified. The latter hypothetical protein is annotated as a Cav3 channel. An EEDD selective filter is found for all three proteins and the core structure of the calcium channel consisting of 24 transmembrane α-helices is reconstructed. Nevertheless, the studied proteins differ in cytoplasmic domains, which indicates a different specialization of Cav3 channels when conducting a signal into the cell. For example, part of the AID motif (alpha-interacting domain) and the adjacent potential sensor from the annotated channel have homology in 25 species of bony fish, and the corresponding region from other channels in 41 species of bony fish and in 4 species of snakes. Significantly, a highly conserved IIS1-S2 loop with the IEHHNQP sequence is found below the AID motif of bony fish, as in trichoplax; while a homologous IEHHEQP sequence is found in snakes, characterized by a negative glutamic acid residue, which is also present in the corresponding rat and human proteins. Based on the analysis of primary transcripts and mature polypeptides, a modular mechanism for the evolution of Cav3 channels is proposed by inserting and combining protein domains performing various regulatory functions.
      PubDate: 2024-02-01
       
  • Regularities of Induction and Growth of Tumors in Mice upon Irradiation of
           Ehrlich Carcinoma Cells Ex Vivo and In Vivo with a Pencil Scanning Beam of
           Protons

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      Abstract: Abstract The patterns of tumor induction and growth in mice under single irradiation ex vivo and in vivo of ascitic Ehrlich carcinoma (EAC) cells with a proton beam at doses of 30, 60, and 80 Gy are studied. It is shown that the frequency of tumor induction after the proton irradiation of EAC cells at a dose of 30 Gy under ex vivo irradiation was lower than after in vivo irradiation, and at doses of 60 Gy and 80 Gy, the number of tumors was the same. The temporal patterns of tumor occurrence in the ex vivo irradiation of EAC cells differed significantly from those after in vivo irradiation of the tumor: the time period during which the appearance of new tumors was recorded in the ex vivo groups was the same for all the studied doses, while when tumors were irradiated in vivo, this interval depended on the dose. The rate of tumor growth after the ex vivo and in vivo irradiation of cells does not depend on the dose, irradiation conditions, or time of their occurrence, but is significantly lower than in the control nonirradiated groups. The results obtained are of interest for understanding the mechanisms of potentially lethal damage to tumor cells, the role of the tumor microenvironment in inducing relapses, and ways to overcome them using the potential of proton therapy, as well as for developing biomedical models to find optimal targets for hadron cancer therapy.
      PubDate: 2024-02-01
       
  • On Methodological Errors in Estimating the Initial Velocities of
           Enzyme-Catalyzed Reactions and Approaches to Their Correction: A Case
           Study with Lactate Dehydrogenase

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      Abstract: A universal algorithm for calculating the initial velocities of enzymatic reactions at the “zero” moment of time according to the kinetic curve of substrate consumption or product accumulation during direct kinetic measurements of enzyme activity is presented. The study was performed using the example of a commercial lactate dehydrogenase preparation and a standard biochemical set of reagents. The proposed approach makes it possible to practically eliminate systematic measurement error, to determine the initial reaction velocity with equal accuracy regardless of the level of enzyme activity, to reduces the analysis time to 1 min, and to expand the scope of application of standard reagent kits for the study of samples of enzymes of different origin in solving a wide range of tasks. The algorithm cannot be applied when using conjugated enzyme systems in an analytical procedure, since in this case there is a long initial lag phase on the kinetic curves.
      PubDate: 2023-12-01
      DOI: 10.1134/S0006350923060118
       
 
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  Subjects -> BIOLOGY (Total: 3134 journals)
    - BIOCHEMISTRY (239 journals)
    - BIOENGINEERING (143 journals)
    - BIOLOGY (1491 journals)
    - BIOPHYSICS (53 journals)
    - BIOTECHNOLOGY (243 journals)
    - BOTANY (220 journals)
    - CYTOLOGY AND HISTOLOGY (32 journals)
    - ENTOMOLOGY (67 journals)
    - GENETICS (152 journals)
    - MICROBIOLOGY (265 journals)
    - MICROSCOPY (13 journals)
    - ORNITHOLOGY (26 journals)
    - PHYSIOLOGY (73 journals)
    - ZOOLOGY (117 journals)

BIOPHYSICS (53 journals)

Showing 1 - 43 of 43 Journals sorted alphabetically
Acta Biochimica et Biophysica Sinica     Hybrid Journal   (Followers: 5)
Advanced NanoBiomed Research     Open Access   (Followers: 1)
Archives of Biochemistry and Biophysics     Hybrid Journal   (Followers: 11)
BBA Advances     Open Access   (Followers: 2)
BBA Bioenergetics     Hybrid Journal   (Followers: 4)
BBA Biomembranes     Hybrid Journal   (Followers: 10)
Biochemical and Biophysical Research Communications     Hybrid Journal   (Followers: 10)
Biochemistry and Biophysics Reports     Open Access   (Followers: 1)
Biochimica et Biophysica Acta (BBA) - General Subjects     Hybrid Journal   (Followers: 9)
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids     Hybrid Journal   (Followers: 6)
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease     Hybrid Journal   (Followers: 6)
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research     Hybrid Journal   (Followers: 8)
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics     Hybrid Journal   (Followers: 6)
Bioinspired, Biomimetic and Nanobiomaterials     Hybrid Journal   (Followers: 3)
Biophysical Chemistry     Hybrid Journal   (Followers: 7)
Biophysical Journal     Hybrid Journal   (Followers: 50)
Biophysical Reports     Open Access   (Followers: 4)
Biophysical Reviews and Letters     Hybrid Journal   (Followers: 6)
Biophysics     Hybrid Journal   (Followers: 10)
Biophysics Reports     Open Access  
Cell Biochemistry and Biophysics     Hybrid Journal   (Followers: 9)
Doklady Biochemistry and Biophysics     Hybrid Journal   (Followers: 1)
European Biophysics Journal     Hybrid Journal   (Followers: 4)
Food Biophysics     Hybrid Journal   (Followers: 2)
Freshwater Biology     Hybrid Journal   (Followers: 34)
GSTF Journal of BioSciences     Open Access   (Followers: 1)
IEEE Life Sciences Letters     Hybrid Journal  
IEEE Nanotechnology Express     Hybrid Journal   (Followers: 16)
International Journal of Biochemistry and Biophysics     Open Access   (Followers: 1)
International Journal of Biophysics     Open Access  
Journal of Biopharmaceutical Statistics     Hybrid Journal   (Followers: 17)
Journal of Biophotonics     Hybrid Journal   (Followers: 1)
Journal of Biophysical Chemistry     Open Access   (Followers: 5)
Journal of Biophysics and Structural Biology     Open Access   (Followers: 5)
Membranes and Membrane Technologies     Full-text available via subscription  
Nanomedicine: Nanotechnology, Biology and Medicine     Hybrid Journal   (Followers: 5)
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Nature Communications     Open Access   (Followers: 508)
Progress in Biophysics and Molecular Biology     Hybrid Journal   (Followers: 1)
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Statistics in Biopharmaceutical Research     Full-text available via subscription   (Followers: 10)
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