Subjects -> CHEMISTRY (Total: 986 journals)
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ORGANIC CHEMISTRY (47 journals)

Showing 1 - 41 of 41 Journals sorted alphabetically
ACS Omega     Open Access   (Followers: 2)
Advances in Image and Video Processing     Open Access   (Followers: 18)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 4)
Advances in Redox Research     Open Access   (Followers: 4)
American Journal of Organic Chemistry     Open Access   (Followers: 15)
Asian Journal of Organic Chemistry     Hybrid Journal   (Followers: 4)
Beilstein Journal of Organic Chemistry     Open Access   (Followers: 13)
Biochemia Medica     Open Access  
Current Organic Chemistry     Hybrid Journal   (Followers: 14)
Current Organic Synthesis     Hybrid Journal   (Followers: 12)
European Journal of Organic Chemistry     Hybrid Journal   (Followers: 59)
Herbal Medicine: Open Access     Open Access  
International Journal of Organic Chemistry     Open Access   (Followers: 9)
International Journal of Polymeric Materials     Hybrid Journal   (Followers: 6)
Journal of Bioactive and Compatible Polymers     Hybrid Journal   (Followers: 2)
Journal of Biomaterials Science, Polymer Edition     Hybrid Journal   (Followers: 9)
Journal of Organic Semiconductors     Open Access   (Followers: 6)
Journal of Peptide Science     Hybrid Journal   (Followers: 14)
Journal of Physical Organic Chemistry     Hybrid Journal   (Followers: 8)
Journal of Physiology and Biochemistry     Hybrid Journal   (Followers: 3)
Journal of Progressive Research in Chemistry     Open Access  
Journal of Proteins and Proteomics     Open Access   (Followers: 2)
Mini-Reviews in Organic Chemistry     Hybrid Journal   (Followers: 10)
Nigerian Journal of Chemical Research     Full-text available via subscription   (Followers: 1)
Open Journal of Organic Polymer Materials     Open Access   (Followers: 1)
Organic & Biomolecular Chemistry     Hybrid Journal   (Followers: 56)
Organic and Medicinal Chemistry Letters     Open Access   (Followers: 5)
Organic Chemistry : Current Research     Open Access   (Followers: 12)
Organic Chemistry Frontiers     Hybrid Journal   (Followers: 9)
Organic Chemistry International     Open Access   (Followers: 7)
Organic Geochemistry     Hybrid Journal   (Followers: 3)
Organic Letters     Hybrid Journal   (Followers: 92)
Organic Preparations and Procedures International: The New Journal for Organic Synthesis     Hybrid Journal   (Followers: 3)
Organic Process Research & Development     Hybrid Journal   (Followers: 32)
Progress in Organic Coatings     Hybrid Journal   (Followers: 7)
Reports in Organic Chemistry     Open Access   (Followers: 7)
Russian Journal of Organic Chemistry     Hybrid Journal   (Followers: 3)
Synthetic Communications: An International Journal for Rapid Communication of Synthetic Organic Chemistry     Hybrid Journal   (Followers: 31)
The Journal of Organic Chemistry     Hybrid Journal   (Followers: 135)
Vibrational Spectroscopy     Hybrid Journal   (Followers: 11)
World Journal of Organic Chemistry     Open Access   (Followers: 5)
Similar Journals
Journal Cover
Journal of Bioactive and Compatible Polymers
Journal Prestige (SJR): 0.446
Citation Impact (citeScore): 2
Number of Followers: 2  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0883-9115 - ISSN (Online) 1530-8030
Published by Sage Publications Homepage  [1169 journals]
  • Development of poly(ethyleneimine) grafted amphiphilic copolymers:
           Evaluation of their cytotoxicity and ability to complex DNA

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      Authors: Ivonne L Diaz, Valérie Jérôme, Ruth Freitag, León D Perez
      Pages: 447 - 463
      Abstract: Journal of Bioactive and Compatible Polymers, Volume 36, Issue 6, Page 447-463, November 2021.
      Poly(ethyleneimine) (PEI) is one of the most widely used cationic polymers for gene delivery. The high molecular weight polymer, which is commercially available, is highly efficient but also very cytotoxic. The reduction in charge density by using nonlinear architectures based on low molecular weight (LMW) PEI is a promising approach to produce safer DNA-vectors. Herein, a group of cationic graft copolymers with different composition containing a hydrophobic biocompatible backbone and LMW linear PEI (lPEI) grafts obtained by ring opening polymerization and click chemistry was studied. The self-assembly and DNA complexation behavior of these materials was analyzed by the gel retardation assay, zeta potential measurements, and dynamic light scattering. The copolymers formed positively charged particles in water with average sizes between 270 and 377 nm. After they were added to DNA in serum-free medium, these particles acquired negative/near-neutral charges and increased in size depending on the N/P ratio. All copolymers showed reduced cytotoxicity compared to the 25 kDa lPEI used as reference, but the transfection efficiency was reduced. This result suggested that the cationic segments were too small to fully condense the DNA and promote cellular uptake, even with the use of several grafts and the introduction of hydrophobic domains. The trends found in this research showed that a higher degree of hydrophobicity and a higher grafting density can enhance the interaction between the copolymers and DNA. These trends could direct further structural modifications in the search for effective and safe vectors based on this polycation.
      Citation: Journal of Bioactive and Compatible Polymers
      PubDate: 2021-10-28T01:18:39Z
      DOI: 10.1177/08839115211053925
      Issue No: Vol. 36, No. 6 (2021)
       
  • Synthesis and characterization of levan hydrogels and their use for
           resveratrol release

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      Authors: Sinem Selvin Selvi, Merve Erginer Hasköylü, Seval Genç, Ebru Toksoy Öner
      Pages: 464 - 480
      Abstract: Journal of Bioactive and Compatible Polymers, Volume 36, Issue 6, Page 464-480, November 2021.
      Considering the need for systematic studies on levan based hydrogels to widen their use in drug delivery systems and biomedical applications, this study is mainly focused on the synthesis and comprehensive characterization as well as drug release properties of hydrogels based on Halomonas levan (HL) and its chemical derivatives. For this, hydrolyzed and phosphonated HL derivatives were chemically synthesized and then cross-linked with 1,4-Butanediol diglycidyl ether (BDDE) and the obtained hydrogels were characterized in terms of their swelling, adhesivity, and rheological properties. Both native and phosphonated HL hydrogels retained their rigid gel like structure with increasing shear stress levels and tack test analysis showed superior adhesive properties of the phosphonated HL hydrogels. Moreover, hydrogels were loaded with resveratrol and entrapment and release studies as well as cell culture studies with human keratinocytes were performed. Biocompatible and adhesive features of the hydrogels confirmed their suitability for tissue engineering and drug delivery applications.
      Citation: Journal of Bioactive and Compatible Polymers
      PubDate: 2021-10-29T10:37:02Z
      DOI: 10.1177/08839115211055725
      Issue No: Vol. 36, No. 6 (2021)
       
  • Osteo-conductive hydrogel scaffolds of poly(vinylalcohol) with silk
           fibroin particles for bone augmentation: Structural formation and in vitro
           testing

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      Authors: Dan Zhao, Thongchai Nuntanaranont, Nuttawut Thuaksubun, Jirut Meesane
      Pages: 481 - 496
      Abstract: Journal of Bioactive and Compatible Polymers, Volume 36, Issue 6, Page 481-496, November 2021.
      Bone augmentation is an effective approach to treat patients who have bone loss at the maxillofacial area. In this research, osteo-conductive hydrogel scaffolds of poly(vinylalcohol) (PVA) with silk fibroin particles (SFP) were fabricated. The SFP were formed by dropping a solution of silk fibroin into acetone at different volume ratios (v/v) of silk to acetone: 1:3 (SFP-3), 1:6 (SFP-6), 1:12 (SFP-12), and 1:24 (SFP-24). The various SFP solutions were mixed with a PVA solution before fabrication into hydrogels by freeze-thawing. Afterwards, the hydrogels were freeze-dried to fabricate the scaffolds. The particle size and charge, molecular organization, and morphology of the SFP were characterized and observed with dynamic light scattering, Fourier transform infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy (SEM). The morphologies of the hydrogel scaffolds were observed with SEM. Swelling percentage was used to assess the swelling behavior of the hydrogel scaffolds. The mechanical properties were also tested. The scaffolds were cultured with osteoblast cells to test the biological performance, cell viability and performance, alkaline phosphatase activity, calcium deposition, and total protein. The SFP-24 was the smallest in particle size. PVA hydrogel scaffolds with SFP-24 demonstrated low particle aggregation, good particle distribution within the scaffold, and a lower swelling percentage. PVA hydrogel scaffolds with SFP had higher mechanical stability than scaffolds without the SFP. Furthermore, the PVA hydrogel scaffold with SFP-24 had better biological performance. Finally, the results demonstrated that PVA hydrogel scaffolds with SFP-24 showed good osteo-conductive performance which is promising for bone augmentation.
      Citation: Journal of Bioactive and Compatible Polymers
      PubDate: 2021-10-25T10:17:46Z
      DOI: 10.1177/08839115211055720
      Issue No: Vol. 36, No. 6 (2021)
       
  • Preparation of liposomal nanocarrier by extruder to enhance tumor
           accumulation of paclitaxel

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      Authors: Ngoc Thuy Trang Le, Ngoc Hoi Nguyen, Minh Chau Hoang, Cuu Khoa Nguyen, Dai Hai Nguyen, Dieu Linh Tran
      First page: 3
      Abstract: Journal of Bioactive and Compatible Polymers, Ahead of Print.
      Despite the wide-spectrum and effective anti-cancer activity of paclitaxel (PTX), their low solubility and side effects are the main challenges in their clinical application. In this study, a model paclitaxel-encapsulated nanoliposome (NLips-PTX) carrier was synthesized to enhance PTX solubility and increase its passive accumulation at the tumor site. Soy lecithin and cholesterol at a 9:1 ratio were used to prepare the nano-sized liposomes through the thin-film hydration followed by extrusion technique. The prepared spherical NLips-PTX liposomes with an average size of about 150 nm and high uniformity were characterized by DLS and TEM. PTX load efficiency of NLips was determined at about 85% by HPLC. NLips-PTX also showed a therapeutic effect toward breast cancer cells (MCF-7) in a dose- and time-dependent manner via in vitro cellular uptake and a cytotoxicity study. This research indicates that extrusion is a simple and convenient method for nano-sizing and homogenising liposome suspension for potentially effective delivery of drug to target tumor sites.
      Citation: Journal of Bioactive and Compatible Polymers
      PubDate: 2021-11-06T06:13:10Z
      DOI: 10.1177/08839115211053926
       
  • A sunscreen nanoparticles polymer based on prolonged period of protection

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      Authors: Ebtesam A Mohamad, Monira M Rageh, Mirhan Mostafa Darwish
      First page: 17
      Abstract: Journal of Bioactive and Compatible Polymers, Ahead of Print.
      UV rays are one of the most dangerous factors that harm the skin. There is continuous improvement in getting an effective sunscreen that protects the skin from excessive exposure to UV rays. Typically, phenylbenzimidazole-5-sulfonic acid (PBSA) is used as a sun blocking agent, but its disadvantage is that it can photodegrade and cause cell damage. In our work, PBSA was encapsulated in niosomes nanoparticles then coated with chitosan-aloe vera (CS-nio-aloe/PBSA) to form a carrier polymer with novel and potent properties. This polymer controls PBSA release and epidermal penetration. Characterization of CS-nio-aloe/PBSA polymer nanoparticles through transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and dynamic light scattering (DLS). The carrier polymer release rate was studied in vitro and epidermal permeability to coated PBSA was assessed using mouse skin. The nanoparticle polymer containing sunscreen was effectively prepared with an encapsulation efficiency of 80%. The formulation (CS-nio-aloe/PBSA) was completely deposited on the surface of the skin. This supports its use to protect the skin, and its nanostructures stimulate the release of PBSA for a longer period. Encapsulation of PBSA in CS-nio-aloe nanoparticles could allow for further cellular preservation, UV protection, control of free PBSA, and limited penetration through the mouse skin epidermis.
      Citation: Journal of Bioactive and Compatible Polymers
      PubDate: 2021-12-18T06:55:51Z
      DOI: 10.1177/08839115211061741
       
  • Cell proliferative properties of Forcespinning® nopal composite
           nanofibers

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      Authors: Cristobal Rodriguez, Victoria Padilla, Karen Lozano, Fariha Ahmad, Alejandra Chapa, Alexa Villarreal, Andrew McDonald, Luis Materon, Robert Gilkerson
      First page: 28
      Abstract: Journal of Bioactive and Compatible Polymers, Ahead of Print.
      In this study, Forcespinning® was used to produce nanofibers composed of Opuntia cochenillifera, “nopal,” mucilage (N) extract, chitosan (CH), and pullulan (PL) (N/CH/PL). These nopal-incorporating nanofibers were examined for their ability to sustain adhesion and proliferation of mouse embryonic fibroblast (NIH 3T3) cells. After a 6-day incubation period, N/CH/PL nanofibers displayed robust cell proliferation, with continued cell growth after an extended incubation period of 14 days. These results demonstrate that natural bioactive compounds can be combined with biodegradable polymers to provide an enhanced environment for cell growth, suggesting potential natural active ingredients as alternatives in wound dressings.
      Citation: Journal of Bioactive and Compatible Polymers
      PubDate: 2021-11-23T09:16:39Z
      DOI: 10.1177/08839115211060404
       
  • Accelerating skin barrier repair using novel bioactive magnesium-doped
           nanofibers of non-mulberry silk fibroin during wound healing

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      Authors: Sharda Gupta, Pallab Dutta, Veena Acharya, Pushpa Prasad, Amit Roy, Arindam Bit
      First page: 38
      Abstract: Journal of Bioactive and Compatible Polymers, Ahead of Print.
      Novel magnesium doped non-mulberry silk fibroin nanofibers with ability to enhance skin barrier function were successfully fabricated using electrospinning technique for wound healing applications. Magnesium nanoparticles incorporated in the electrospun nanofibers releases Mg2+ ions at the site of implementation. The effect of Mg2+ is of considerable concern in wound healing due to its skin barrier repair ability and its role in blood coagulation. The physicochemical characterization of the scaffold was investigated by determining the morphology and secondary structure confirmation. The effects of Mg2+ ions in silk fibroin microenvironment have been evaluated using SEM, XRD, and FTIR to confirm the incorporation of magnesium in the film. The aim of this study is to see the effect of doped Mg on the structural, physical, and biological properties of non-mulberry silk fibroin (NSF) film. The magnesium doped nanofibrous film exhibited enhanced mechanical property, satisfactory blood clotting ability, and good in vitro degradability. This silk fibroin-based film mimicking extracellular matrix for skin regeneration were constructed using electrospinning technique. The wound healing efficiency of prepared nanofibers were evaluated in full-thickness wound models of rat. The Mg doped silk fibroin film exhibited faster wound healing activity (14 days) among all experimental group. The study indicates the potential of magnesium-doped silk /PVA film as skin substitute film.
      Citation: Journal of Bioactive and Compatible Polymers
      PubDate: 2021-11-23T09:21:57Z
      DOI: 10.1177/08839115211061737
       
  • A study of the electrophoretic deposition of
           polycaprolactone-chitosan-bioglass nanocomposite coating on stainless
           steel (316L) substrates

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      Authors: Zahra Sadeghinia, Rahmatollah Emadi, Fatemeh Shamoradi
      First page: 53
      Abstract: Journal of Bioactive and Compatible Polymers, Ahead of Print.
      In this research, bioglass nanoparticles were synthesized via sol-gel method and a polycaprolactone-chitosan-bioglass nanocomposite coating was formed on SS316L substrate using electrophoretic deposition method. Then, the effects of voltage and deposition time on morphology, thickness, roughness, and wettability of final coating were investigated. Finally, biocompatibility and toxicity of the coating were evaluated. The results showed that increase of both time and voltage enhanced the thickness, roughness, and wettability of coating. Also, increase of deposition time increased the agglomeration. Therefore, it can be concluded that voltage of 20 V and time of 10 min are suitable for the formation of a uniform agglomerate-free coating. The presence of bioglass nanoparticles also led to the increase of roughness and improvement of polycaprolactone hydrophobicity. The results also showed higher bioactivity in polycaprolactone-chitosan-1% bioglass nanocomposite coating sample. This sample had a roughness (Ra) of 1.048 ± 0.037 μm and thickness of 2.54 ± 0.14 μm. In summary, the results indicated that coating of polycaprolactone-chitosan-bioglass nanocomposite on SS316L substrate could be a suitable surface treatment to increase its in vivo bioactivity and biocompatibility.
      Citation: Journal of Bioactive and Compatible Polymers
      PubDate: 2021-12-09T12:17:43Z
      DOI: 10.1177/08839115211063506
       
  • Biofabrication of controllable alginate hydrogel cell scaffolds based on
           bipolar electrochemistry

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      Authors: Fei Xie, Changyue Li, Xiaoqing Hua, Li Ma
      First page: 497
      Abstract: Journal of Bioactive and Compatible Polymers, Ahead of Print.
      Bipolar electrochemistry successfully realized the electrodeposition of calcium alginate hydrogels in specific target areas in tissue engineering. However, the shape and quantity of three-dimensional cannot be accurately controlled. We presented a novel growth model for fabricating hydrogels based on bipolar electrochemical by patterned bipolar electrodes using photolithography. This work highlights pattern customization and quantitative control of hydrogels in cell culture platforms. Furthermore, alginate hydrogels with different heights can be controlled by adjusting the key parameters of the growth model. This strategy exhibits promising potential for cell-oriented scaffolds in tissue engineering.
      Citation: Journal of Bioactive and Compatible Polymers
      PubDate: 2021-10-19T05:01:42Z
      DOI: 10.1177/08839115211053920
       
  • Wound healing and antibacterial activities of water-soluble chitosan
           nanoparticles and excretion/secretion as a natural combination from
           medicinal maggots, Lucilia cuprina

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      Authors: Mohammad RK Abdel-Samad, Fatma A Taher
      First page: 510
      Abstract: Journal of Bioactive and Compatible Polymers, Ahead of Print.
      Wounds management takes a high interest in the medical field and the addition of antimicrobial agents in an assortment of wound dressings leads to delay the wound healing. This study aimed at preparing natural combination between excretion/secretion (ES) and water-soluble chitosan nanoparticles (from Lucilia cuprina maggots) and investigating its antibacterial and wound healing activities. ES of maggots was collected, and the water-soluble chitosan nanoparticles (WSCNPs) were prepared and characterized. Antibacterial activities of combinations were evaluated against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Proteus vulgaris. ES-WSC-2 combination that contains 50% ES and 1% WSCNPs showed highest antibacterial activity against all tested bacteria compared to the other combinations. In vitro, the ES-WSC-2 combination was used to study the wound healing activity by scratch assay. The synergism between ES and WSCNPs (in ES-WSC-2 combination) accelerated the wound healing rate which suggests the use of this combination as an effective natural antibacterial and wound healing agent.
      Citation: Journal of Bioactive and Compatible Polymers
      PubDate: 2021-10-20T05:13:50Z
      DOI: 10.1177/08839115211053921
       
  • Enhanced anticancer efficacy of docetaxel through galbanic acid
           encapsulated into PLA-PEG nanoparticles in treatment of colon cancer, in
           vitro and in vivo study

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      Authors: Maryam Hashemi, Maryam Afsharzadeh, Maryam Babaei, Mahboubeh Ebrahimian, Khalil Abnous, Mohammad Ramezani
      First page: 520
      Abstract: Journal of Bioactive and Compatible Polymers, Ahead of Print.
      Cancer is one of the most leading causes of human mortality and despite outstanding breakthrough in introducing new therapeutic approaches, the clinical outcomes are disappointing. Therefore, extensive research in design and preparation of more efficient drug delivery systems can open a window to shine light into the therapeutic modality. In this study, we evaluated the effect of galbanic acid (GBA) encapsulated into PLA-PEG nanoparticles (NPs) to enhanced anticancer efficacy of docetaxel (DOC) for the treatment of colon cancer. Prepared NPs were characterized by different methods in terms of size, zeta potential, and drug loading capacity. MTT assay was used to investigate the anti-proliferation of GBA-loaded PEG-PLA NPs along with DOC. The therapeutic efficacy of PEG-PLA@GBA NPs & DOC was further investigated in C26 tumor-bearing BALB/c mice model. The resulting NPs were narrowly distributed (PDI = 0.06) with the mean diameter of 148 ± 9 nm with somewhat negative charge. GBA were efficiently loaded into mPEG-PLA NPs with encapsulation efficiency of about 40% ± 3. Cytotoxicity studies showed that NPs loaded with GBA and fixed concentration of docetaxel (20 nM) have higher toxicity (IC50 = 6 ± 1.8 µM) than either PEG-PLA@GBA (IC50 = 8 ± 1.2 µM) or free GBA (IC50 = 15 ± 3.5 µM) in C26 cells. In vivo studies revealed a synergistic effect of PEG-PLA@GBA NPs and DOC on tumor growth inhibition and survival rate in comparison with monotherapy approach.
      Citation: Journal of Bioactive and Compatible Polymers
      PubDate: 2021-10-20T05:16:04Z
      DOI: 10.1177/08839115211053922
       
  • Preparation and characterization of conductive nerve guide conduit filled
           with dual drug-loaded nanofibers

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      Authors: Xiumei Yan, Yi Yu, Shaobing Wang, Haixing Xu, Qundi He, Jing Wen, Jingyi Xu, Kebi Li, Zhijun Huang, Peihu Xu
      First page: 531
      Abstract: Journal of Bioactive and Compatible Polymers, Ahead of Print.
      Peripheral nerve injury (PNI) has become one of the common clinical diseases. How to promote the regeneration and function recovery of the damaged peripheral nerve has been the focus of attention in the medical field. Evidence suggests that the longitudinal filling of oriented fibers in nerve guide conduit (NGC) is especially beneficial to the repair of long gap PNI. In this study, polypyrrole (PPy) nanospheres (PNSs) were prepared by the soft-templating method, and mixed with poly (lactic acid) (PLA) to prepare conductive PNSs/PLA NGC, and the optimal ratio of PNSs was 4.5%. PLA and vascular endothelial growth factor (VEGF) as shell, chitosan (CS) and paeoniflorin (PF) as core, oriented coaxial nanofibers were obtained and then filled into PNSs/PLA NGC. The composite NGC has excellent mechanical properties, electrical conductivity, hydrophilic properties, and degradation properties. Besides, the successive release of VEGF and PF can play a synergistic role in promoting nerve regeneration. In vitro experiments showed that the composite NGC was nontoxic and suitable for the adhesion and proliferation of nerve cells. In addition, PNSs combined with electrical stimulation (ES) can significantly promote the differentiation and proliferation of nerve cells, which is conducive to nerve regeneration. These positive results indicate that the composite NGC is a promising candidate in the repair of long gap PNI.
      Citation: Journal of Bioactive and Compatible Polymers
      PubDate: 2021-10-20T05:10:45Z
      DOI: 10.1177/08839115211053917
       
 
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