JournalTOCs

Journal of Bioactive and Compatible Polymers
Journal Prestige (SJR): 0.446

Citation Impact (citeScore): 2
Number of Followers: 3

Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0883-9115 - ISSN (Online) 1530-8030
Published by Sage Publications

[1176 journals]

Fabrication, characterization, and in vivo implantation of eugenol-loaded
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  Authors: Fariba Noori, Mahmoud Osanloo, Hamid Reza Moradi, Hamidreza Ghaderi Jafarbeigloo, Mozhgan Jirehnezhadyan, Seyed Amin Kouhpayeh, Mahtab Tirgare, Azam Bozorgi, Arash Goodarzi
  Pages: 480 - 492
  Abstract: Journal of Bioactive and Compatible Polymers, Volume 38, Issue 6, Page 480-492, November 2023.
  Developing wound dressings with a high potential to cover damaged skin tissue and facilitate cell adhesion and migration at the injury site is crucial in skin tissue engineering to accelerate wound healing. Electrospun nanofibers from natural/synthetic polymers are amongst the favorable wound dressings with appropriate physicochemical and biological properties. As well, nanoformulations of phenolic phytochemical “eugenol” have been shown to fasten wound healing via various anti-inflammatory and anti-oxidant effects. Herein, we developed a bi-component wound dressing of PCL/Cs electrospun nanofibers and eugenol nanogel to investigate its effects on tissue healing in vivo. PCL/Cs nanofibers were fabricated using an electrospinning method at the 15:1 ratio, and eugenol-loaded nanogels were synthesized by adding carboxymethylcellulose as the gelling agent, and their physicochemical characteristics were assessed. Scaffolds were implanted in a full-thickness excision wound model in Wistar rats, followed up for 21 days. The results showed that electrospun nanofibers had an average diameter of 228 nm with uniform and smooth morphology aligned randomly. Eugenol-loaded nanogel showed an average size distribution of 126 nm. Eugenol-loaded nanogel and nanogel + nanofiber groups significantly reduced wound surface area over 21 days. Histological evaluations showed that Eugenol-loaded nanogel and nanogel + nanofiber groups developed the full-thickness epidermis with the complete epithelium and stratum corneum, angiogenesis, and low macrophage infiltration in which predominantly mature collagen fibers were poorly and well organized, respectively. The combination of eugenol-loaded nanogel + PCL/Cs nanofiber accelerated wound healing by reducing inflammation, and edema along with enhancing angiogenesis, collagen synthesis, and re-epithelialization.
  Citation: Journal of Bioactive and Compatible Polymers
  PubDate: 2023-11-09T06:16:09Z
  DOI: 10.1177/08839115231207337
  Issue No: Vol. 38, No. 6 (2023)
Synthesis and characterization of chitosan/polyvinylpyrrolidone hydrogels
for controlled amoxicillin release
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  Authors: Zerihun Feyisa, Neeraj K Gupta, Gemechu Deressa Edossa, Anandhakumar Sundaramurthy, Ashish Kapoor
  Abstract: Journal of Bioactive and Compatible Polymers, Ahead of Print.
  Hybrid crosslinked hydrogel-based drug delivery systems can deliver therapeutically beneficial drug release effects through controlled release on a temporal and spatial scale. Due to their tuneable physicochemical properties and the ability to prevent drug degradation, these systems facilitate different physicochemical interactions that control drug release. This research aims to synthesize a potent pH-sensitive crosslinked chitosan/polyvinylpyrrolidone hydrogel using different ratios of both the polymers and varying the glutaraldehyde crosslinking agent amount by the solution casting technique for controlled amoxicillin-release properties to mitigate gastrointestinal tract bacterial infection. The effect of polymer ratios and glutaraldehyde amount is investigated by the developing porosity, gel fraction, and extent of swelling in simulated physiological fluids of pH 1.2, 6.8, and 7.4 and in vitro biodegradation at pH 7.4. Interaction between the polymers with the formation of crosslinked structures, good stability, amorphous phase nature, and honeycomb-like structures of the hydrogels is revealed by Fourier-transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, and scanning electron microscopy. Based on these properties, a chitosan/polyvinylpyrrolidone hydrogel (ratio of 60:40) crosslinked with 600 μL glutaraldehyde in 8 g of the polymers displaying adequate swelling in acidic to basic pH and in vitro biodegradation at pH 7.4 is chosen for the in situ loading of 200 mg of the drug amoxicillin. The cumulative drug release in simulated physiological fluids and the drug release kinetics using different models show that the best-fit Korsmeyer-Peppas model suggests amoxicillin release from the matrix follows diffusion and swelling-controlled time-dependent non-Fickian transport related to hydrogel erosion. This composition displays excellent antimicrobial activity against Streptococcus pyogenes and Escherichia coli.
  Citation: Journal of Bioactive and Compatible Polymers
  PubDate: 2023-11-02T10:01:25Z
  DOI: 10.1177/08839115231207817
A silk fibroin scaffold that accelerates both biodegradation and cell
proliferation by incorporating sericin
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  Authors: Wenjing Zhang, Xiaoxiao Sun, Peng Pan, Xueping Liu, Cheng Hu, Mengmeng Wang, Mingzhong Li, Yu Liu
  Abstract: Journal of Bioactive and Compatible Polymers, Ahead of Print.
  When 3D silk fibroin scaffolds are used for the regeneration of soft tissues with fast regeneration rates, such as skin dermis, one concern is to accelerate the biodegradation of scaffolds and to match the degradation rate of scaffolds with the regeneration rate of tissues. In this study, sericin was incorporated into 3D silk fibroin scaffolds through crosslinking and followed by freeze-drying. The effects of incorporating sericin on the pore wall microstructure within the scaffolds, the biodegradability of scaffolds and cell proliferation within scaffolds were investigated. It was found that a large number of secondary pores and nanoscale particles were generated on the pore walls within the scaffolds due to the incorporation of sericin and that the number of secondary pores and the size of the particles increased with increasing sericin proportion. The results of in vitro biodegradation and coculture with human umbilical vein vascular endothelial cells demonstrated that the incorporation of sericin not only significantly accelerated the degradation of 3D silk fibroin scaffolds, but also promoted cell adhesion and proliferation. The secondary pores and particles generated on the pore walls inside the fibroin/sericin hybrid scaffolds had a positive contribution to promoting cell adhesion and proliferation. This study provides a biocompatible method for the modification of silk fibroin scaffolds, which can not only accelerate the biodegradation of the scaffold but also promote the adhesion and proliferation of seeded cells.
  Citation: Journal of Bioactive and Compatible Polymers
  PubDate: 2023-11-02T09:52:11Z
  DOI: 10.1177/08839115231207815
Corrigendum to “Vancomycin coupled chitosan/PEO nanofibrous scaffold
with the desired antibacterial activity as a potential for biomedical
application”
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  Abstract: Journal of Bioactive and Compatible Polymers, Ahead of Print.
  
  Citation: Journal of Bioactive and Compatible Polymers
  PubDate: 2023-09-30T09:44:21Z
  DOI: 10.1177/08839115231207193
Design and evaluation of moringa gum-based hydrogel dressings for
cutaneous wound healing
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  Authors: Yasir Iqbal, Shahzad Ali Shahid Chatha, Zunera Chauhdary, Abdullah Ijaz Hussain, Ikram Ullah Khan
  Abstract: Journal of Bioactive and Compatible Polymers, Ahead of Print.
  The study aimed to evaluate moringa gum (MG) and carboxymethyl moringa (CMG) for their possible use in hydrogel-based dressings to treat cutaneous wounds. Initially, MG was characterized for its physical, functional, morphological, and thermal properties. The MG and CMG have shown limited toxicity as indicated by hemolytic assay where values were less than 2.5%. Furthermore, these samples also showed antimicrobial potential. The antioxidant potential of MG was slightly greater than its carboxymethyl derivative. Afterward, MG and CMG were encapsulated in sodium alginate-based hydrogel films. These films showed good physical attributes necessary for the end application. These films were tested in an open wound model in rats. The MG containing films showed the highest % wound contraction on the 10th day, that is,79.42 ± 0.46 with low levels of IL6 and TNF alfa. Out of MG and CMG films, the native moringa gum-based thin film showed comparatively higher potential for wound healing and in the future could be a potential candidate for wound healing dressings.
  Citation: Journal of Bioactive and Compatible Polymers
  PubDate: 2023-09-25T11:41:27Z
  DOI: 10.1177/08839115231199700
Levan-based bioactive hydrogels containing herbal liposome in treating
acute wounds
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  Authors: Özlem Erdal Altıntaş, Pınar Aytar Çelik
  Abstract: Journal of Bioactive and Compatible Polymers, Ahead of Print.
  Hydrogels in active wound care products are 3D polymeric scaffolds that provide the desired moisture balance in the wound area with their high water retention capacity. Thanks to their biocompatible properties, flexible and porous structures, and high hydrophilic properties, they have frequently been preferred in the repair and regeneration of cells and tissues and the controlled release of bioactive substances to the target area. In this study, hydrogel structures were developed for the first time with levan produced by Halomonas elongata 153B halophilic bacteria. Extracts from Plantago lanceolata L., commonly known as a wound herb, which has medicinal importance for cell regeneration, ensuring tissue integrity in a short time and reducing infections in the wound area, were obtained and extract-loaded liposome structures were formed for controlled release into the wound area. The wound healing efficacy of the composite material developed by loading herbal liposomes into levan-based hydrogel structures was evaluated in an in vitro wound model. Thus, a natural, biocompatible, biodegradable, and functional wound care product containing herbal liposomes suitable for both clinical applications and point-of-care use has been developed. The developed bioactive hydrogels are a promising therapeutic approach for the healing of acute wounds.Graphical abstract
  Citation: Journal of Bioactive and Compatible Polymers
  PubDate: 2023-09-20T07:33:17Z
  DOI: 10.1177/08839115231198528
Vancomycin coupled chitosan/PEO nanofibrous scaffold with the desired
antibacterial activity as a potential for biomedical application
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  Authors: Ahmad Gholami, Ali Rahmanian, Esmaeil Mirzaei, Fatemeh Mozaffariyan, Khatereh Asadi, Navid Omidifar
  Abstract: Journal of Bioactive and Compatible Polymers, Ahead of Print.
  This study aims to evaluate the Vancomycin (VCM) combination with Chitosan (CS)/ Polyethylene oxide (PEO) nanofibers’ intrinsic antibacterial properties causing a synergistic effect against possible serious bacterial infections (PSBI). VCM/CS nanofiber scaffold was fabricated using the electrospinning method. Characterizations are performed by Fourier transform infrared (FT-IR) to examine the functional groups of each compound, scanning electron microscopy (SEM), and transient electron microscopy (TEM) to evaluate nanofiber diameter and structure. Antibacterial activities of the nanofibrous scaffold were assessed against bacterial strains, including standard Staphylococcus aureus (S. aureus), VCM-sensitive Enterococcus (VSE), methicillin-resistant S. aureus (MRSA), VCM-resistant Enterococcus (VRE), and Streptococcus group A by microdilution broth methods. The FT-IR, SEM, and TEM examination results confirm the CS/PEO nanofiber scaffold fabrication. The antibacterial examination results showed no significant difference between the minimum inhibitory concentration (MIC) values of VCM and with MIC of VCM/CS nanofibers. Still, there were significant differences between the MIC of CS and VCM/CS nanofibers in S. aureus, but this is not more significant than VCM. This study illustrated that VCM coupled to CS nanofibers had acceptable antibacterial activity against the Gram-positive bacterium. This work motivated researchers’ insight into nanostructures’ potential accompanied by antibacterial polymer and antibiotics synergistic effects against PSBI.
  Citation: Journal of Bioactive and Compatible Polymers
  PubDate: 2023-08-26T11:57:12Z
  DOI: 10.1177/08839115231195796