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Analytical Chemistry Insights
Journal Prestige (SJR): 0.224

Citation Impact (citeScore): 1
Number of Followers: 21

This is an Open Access Journal

Open Access journal
ISSN (Print) 1177-3901
Published by Sage Publications

[1176 journals]

An Accurate Assessment of Docosahexaenoic Acid in Laying Hen Serum for
Regulatory Studies
- Authors: Gerald Patrick Dillon, Geoff Wallace, Alexandros Yiannikouris, Colm Anthony Moran
  Abstract: Analytical Chemistry Insights, Volume 13, Issue , January-December 2018.
  Diets rich in omega-3 fatty acids (n-3 FA) have been associated with several health benefits. With the increased interest in n-3 FA both scientifically and societally, the accurate detection of such analytes has become increasingly important. Recently, tandem mass spectrometry (MS/MS) with electrospray ionization interface (ESI), hyphenated to both gas chromatography (GC) and liquid chromatography (LC), has become a valuable tool in the detection of docosahexaenoic acid (DHA). Liquid chromatography-electrospray ionization interface-tandem mass spectrometry methods have been developed for the determination of DHA in canine and poultry species. The objective of this article is to investigate whether LC-ESI-MS/MS is fit for purpose for the determination of DHA in laying hen serum. The disclosure of this work will be beneficial for researchers investigating poultry enrichment for regulatory and toxicological studies. The method was found to be linear over the range. Precision and accuracy results met acceptance criteria and the Limit of Quantitation (LOQ) was established as 1 µg/mL. Recoveries of DHA were obtained for quality control samples and stability studies were performed. The results of the verification study complimented those of the validation study. In summation, the method was established as fit for purpose for measuring total DHA in laying hen serum.
  Citation: Analytical Chemistry Insights
  PubDate: 2018-12-06T04:01:03Z
  DOI: 10.1177/1177390118815146
  Issue No: Vol. 13 (2018)
In Vitro Studies of the Antimicrobial and Free-Radical Scavenging
Potentials of Silver Nanoparticles Biosynthesized From the Extract of
Desmostachya bipinnata
- Authors: Sitaramanjaneya Reddy Guntur, NS Sampath Kumar, Manasa M Hegde, Vijaya R Dirisala
  Abstract: Analytical Chemistry Insights, Volume 13, Issue , January-December 2018.
  The aim of this study was to perform green synthesis of silver nanoparticles (AgNPs) from the leaf extract of Desmostachya bipinnata (Dharba), a medicinally important herb which is widely used across India. Synthesized AgNPs were analyzed by UV-Visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDAX). The results have confirmed that green synthesis of AgNPs leads to the fabrication of sphere-shaped particles with a diameter of 53 nm. Furthermore, these AgNPs were subjected to antioxidant and antimicrobial studies against gram-negative and gram-positive bacteria, where AgNPs at a concentration of 20 mg/mL showed highest zone of inhibition. Synthesized AgNPs were evaluated for their antioxidant activity by 1, 1-diphenyl-2-picryl hydrazyl radical (DPPH), H2O2, and superoxide inhibiting assays; increasing concentration has showed increase in scavenging ability. Cell toxicity was assessed on HepG2 cell lines, and synthesized nanoparticles at a concentration of 128 μg/mL produced significant reduction in viability of Hep cells (P
  Citation: Analytical Chemistry Insights
  PubDate: 2018-07-02T08:46:33Z
  DOI: 10.1177/1177390118782877
  Issue No: Vol. 13 (2018)
Analytical Methods for the Determination of Mineral Oil Saturated
Hydrocarbons (MOSH) and Mineral Oil Aromatic Hydrocarbons (MOAH)—A Short
Review
- Authors: Sandra Weber, Karola Schrag, Gerd Mildau, Thomas Kuballa, Stephan G Walch, Dirk W Lachenmeier
  Abstract: Analytical Chemistry Insights, Volume 13, Issue , January-December 2018.
  Mineral oils (such as paraffinum liquidum or white oil), which consist of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH), are widely applied in various consumer products such as medicines and cosmetics. Contamination of food with mineral oil may occur by migration of mineral oil containing products from packaging materials, or during the food production process, as well as by environmental contamination during agricultural production. Considerable analytical interest was initiated by the potential adverse health effects, especially carcinogenic effects of some aromatic hydrocarbons. This article reviews the history of mineral oil analysis, starting with gravimetric and photometric methods, followed by on-line-coupled liquid chromatography with gas chromatography and flame ionization detection (LC-GC-FID), which still is considered as gold standard for MOSH-MOAH analysis. Comprehensive tables of applications in the fields of cosmetics, foods, food contact materials, and living organisms are provided. Further methods including GCxGC-MS methods are reviewed, which may be suitable for confirmation of LC-GC-FID results and identification of compound classes. As alternative to chromatography, nuclear magnetic resonance (NMR) spectroscopy has recently been suggested for MOSH-MOAH analysis, especially with the possibility of detecting only the toxicologically relevant aromatic rings. Furthermore, NMR may offer potential as rapid screening especially with low-field instruments usable for raw material control.
  Citation: Analytical Chemistry Insights
  PubDate: 2018-06-04T09:26:12Z
  DOI: 10.1177/1177390118777757
  Issue No: Vol. 13 (2018)
Chitosan Membrane Embedded With ZnO/CuO Nanocomposites for the
- Authors: Eman Alzahrani
  Abstract: Analytical Chemistry Insights, Volume 13, Issue , January-December 2018.
  Fast Green (FCF) dye is commonly used in both cytology and histology applications. Previous studies have found that it can cause mutagenic and tumorigenic effects in experimental human and animal populations. It can also be a source of skin, eye, respiratory, and digestive irritation. The purpose of this study was to examine the use of thin film membranes to degrade FCF. A thin film membrane of chitosan (CS) was fabricated and subsequently filled with zinc oxide nanoparticles (ZnO) or ZnO/CuO-heterostructured nanocomposites. The CS membrane was used as a matrix, and the nanomaterials were used as photocatalysts. The prepared membranes were characterised by four analytical techniques: atomic force microscopy, scanning electron microscopy, X-ray diffraction, and energy-dispersive X-ray analyses. The photocatalytic activity of the fabricated membranes was evaluated by performing experiments in which aqueous solutions of FCF dye that contained the fabricated membrane were irradiated with solar light or UV light. The photodegradation percentage was spectrophotometrically determined by monitoring the maximum wavelengths (λmax) of FCF at 623 nm for different irradiation times. The decolourisation percentages of the dye under solar light were 57.90% and 60.23% using the CS-ZnO and CS-ZnO/CuO membranes, respectively. When UV light irradiation was employed as the source of irradiation, the photodegradation percentages of FCF were 71.45% and 91.21% using the CS-ZnO and CS-ZnO/CuO membranes, respectively. These results indicated that the best photocatalytic system for the degradation of FCF dye was CS-ZnO/CuO membrane in combination with UV light irradiation. The study also found that it was easy to separate the prepared membranes after the reaction without the need for a centrifuge or magnet. The results demonstrate the potential for CS-ZnO and CS-ZnO/CuO membranes for use as effective sorbents during the process of photodegradation of harmful dyes within waste water recycling practices.
  Citation: Analytical Chemistry Insights
  PubDate: 2018-03-21T08:31:42Z
  DOI: 10.1177/1177390118763361
  Issue No: Vol. 13 (2018)
Ten Basic Rules of Antibody Validation
- Authors: Michael G Weller
  Abstract: Analytical Chemistry Insights, Volume 13, Issue , January-December 2018.
  The quality of research antibodies is an issue for decades. Although several papers have been published to improve the situation, their impact seems to be limited. This publication makes the effort to simplify the description of validation criteria in a way that the occasional antibody user is able to assess the validation level of an immunochemical reagent. A simple, 1-page checklist is supplied for the practical application of these criteria.
  Citation: Analytical Chemistry Insights
  PubDate: 2018-02-08T08:42:30Z
  DOI: 10.1177/1177390118757462
  Issue No: Vol. 13 (2018)

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