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ECONOMIC SYSTEMS, THEORIES AND HISTORY (235 journals)                  1 2 | Last

Showing 1 - 200 of 224 Journals sorted alphabetically
Ab Imperio     Full-text available via subscription   (Followers: 4)
Acta Economica     Open Access  
Acta Universitatis Sapientiae, European and Regional Studies     Open Access  
African East-Asian Affairs     Open Access   (Followers: 10)
African Economic History     Full-text available via subscription   (Followers: 20)
African Journal of Economic Policy     Full-text available via subscription   (Followers: 2)
African Journal of Sustainable Development     Full-text available via subscription   (Followers: 8)
African Research Review     Open Access   (Followers: 5)
AL-FALAH : Journal of Islamic Economics     Open Access  
Al-Iqtishad : Journal of Islamic Economics     Open Access   (Followers: 2)
Al-Tijary : Jurnal Ekonomi dan Bisnis Islam     Open Access   (Followers: 1)
América Latina en la historia económica     Open Access   (Followers: 3)
American Economic Journal : Economic Policy     Full-text available via subscription   (Followers: 163)
American Economist     Hybrid Journal   (Followers: 6)
An-Nisbah : Jurnal Ekonomi Syariah     Open Access   (Followers: 1)
Anuario de Estudios Centroamericanos     Open Access   (Followers: 2)
Aquaculture Economics & Management     Hybrid Journal   (Followers: 21)
ASAS : Jurnal Hukum dan Ekonomi Islam     Open Access   (Followers: 1)
Asian Bulletin of Energy Economics and Technology     Open Access   (Followers: 1)
Asian Journal for Poverty Studies     Open Access   (Followers: 4)
Asian Journal of Quality of Life     Open Access   (Followers: 1)
AUDITING: A Journal of Practice & Theory     Full-text available via subscription   (Followers: 13)
Australian Economic History Review     Hybrid Journal   (Followers: 8)
BioPhysical Economics and Resource Quality     Hybrid Journal  
Boletim de Conjuntura Econômica     Open Access  
Buletin Ekonomi     Open Access   (Followers: 1)
Bulletin of Economic Theory and Analysis     Open Access   (Followers: 2)
Business History     Hybrid Journal   (Followers: 22)
Business History Review     Hybrid Journal   (Followers: 16)
Cadernos do Desenvolvimento Fluminense     Open Access  
Cahiers du GRM     Open Access  
Ciencias Económicas     Open Access  
Comparative Economic Studies     Hybrid Journal   (Followers: 6)
Competition and Regulation in Network Industries     Full-text available via subscription   (Followers: 7)
Con-texto     Open Access  
Conjuntura Austral : Journal of the Global South     Open Access   (Followers: 2)
Construction Economics and Building     Open Access   (Followers: 4)
Contemporary Economic Policy     Hybrid Journal   (Followers: 9)
Contemporary Economy     Open Access  
Contemporary Review of the Middle East     Full-text available via subscription   (Followers: 10)
Cooperativismo & Desarrollo     Open Access  
Corporate Governance and Sustainability Review     Open Access   (Followers: 2)
Croatian Review of Economic, Business and Social Statistics     Open Access  
Cuadernos de Economía     Open Access  
Cuadernos de historia. Serie Economía y Sociedad     Open Access  
Cuadernos del CENDES     Open Access  
Cultura Económica     Open Access  
Development Management     Open Access   (Followers: 1)
E-Jurnal Ekonomi Pembangunan Universitas Udayana     Open Access  
Eastern European Countryside     Open Access   (Followers: 2)
Econometric Research in Finance     Open Access  
Econometric Theory     Hybrid Journal   (Followers: 20)
Econometrics     Open Access   (Followers: 9)
Econometrics and Statistics     Hybrid Journal   (Followers: 1)
Economía : Teoria y práctica     Open Access  
Economía Mexicana. Nueva Época     Open Access   (Followers: 1)
Economia Politica     Hybrid Journal   (Followers: 42)
Economía UNAM     Open Access  
Economia y Sociedad     Open Access   (Followers: 1)
Economía y Sociedad     Open Access  
Economia, Sociedad y Territorio     Open Access  
Economic Analysis     Open Access   (Followers: 4)
Economic Anthropology     Full-text available via subscription   (Followers: 18)
Economic Education Analysis Journal     Open Access  
Economic History of Developing Regions     Hybrid Journal   (Followers: 6)
Economic Journal of Emerging Markets     Open Access   (Followers: 1)
Economic Research-Ekonomska Istraživanja     Open Access  
Economic Theory     Hybrid Journal   (Followers: 18)
Economic Theory Bulletin     Hybrid Journal   (Followers: 1)
Economica : Jurnal Ekonomi Islam     Open Access   (Followers: 1)
Economics and Law     Open Access   (Followers: 3)
Economics Bosowa     Open Access  
Economics Development Analysis Journal     Open Access   (Followers: 5)
Economics of Development     Open Access   (Followers: 2)
EMAJ : Emerging Markets Journal     Open Access  
Emerging Economies Cases Journal     Hybrid Journal  
Emerging Economy Studies     Full-text available via subscription   (Followers: 1)
Empirical Economic Review     Open Access   (Followers: 1)
Ensayos de Economía     Open Access  
Ensayos Revista de Economía     Open Access  
Entrepreneurship Theory and Practice     Hybrid Journal   (Followers: 48)
Environmental Economics     Open Access   (Followers: 2)
Erhvervshistorisk Årbog     Open Access   (Followers: 1)
Espaço & Economia : Revista Brasileira de Geografia Econômica     Open Access  
Essays in Economic & Business History     Open Access   (Followers: 3)
Estonian Discussions on Economic Policy     Open Access  
Estudios de Economía     Open Access  
Ethiopian Journal of Economics     Full-text available via subscription   (Followers: 4)
European Countryside     Open Access   (Followers: 1)
European Journal of Economics and Economic Policies : Intervention     Full-text available via subscription   (Followers: 13)
European Journal of the History of Economic Thought     Hybrid Journal   (Followers: 13)
European Review of Economic History     Hybrid Journal   (Followers: 35)
Evolutionary and Institutional Economics Review     Hybrid Journal   (Followers: 1)
Explorations in Economic History     Hybrid Journal   (Followers: 34)
Expresión Económica : Revista de Análisis     Open Access  
FALAH : Jurnal Ekonomi Syariah     Open Access  
Foundation Review     Full-text available via subscription   (Followers: 2)
Germinal : Marxismo e Educação em Debate     Open Access  
Ghana Journal of Development Studies     Full-text available via subscription   (Followers: 8)
Gizarte Ekonomiaren Euskal Aldizkaria : Revista Vasca de Economía Social     Open Access  
Hakam : Jurnal Kajian Hukum Islam dan Hukum Ekonomi Islam     Open Access  
History of Economic Thought and Policy     Full-text available via subscription   (Followers: 10)
History of Economics Review     Hybrid Journal   (Followers: 11)
I-ECONOMICS : A Research Journal on Islamic Economics     Open Access  
Iberian Journal of the History of Economic Thought     Open Access  
Ikonomika : Jurnal Ekonomi dan Bisnis Islam     Open Access  
Indian Economic & Social History Review     Hybrid Journal   (Followers: 10)
Indian Economic Journal     Full-text available via subscription  
Indian Economic Review     Hybrid Journal  
Informe Econômico     Open Access   (Followers: 3)
International Journal of Business Intelligence Research     Full-text available via subscription   (Followers: 3)
International Journal of Economic Policy Studies     Hybrid Journal   (Followers: 1)
International Journal of Economic Theory     Hybrid Journal   (Followers: 4)
International Journal of Economics and Financial Issues     Open Access   (Followers: 10)
International Journal of Energy Economics and Policy     Open Access   (Followers: 11)
International Journal of Game Theory     Hybrid Journal   (Followers: 3)
International Journal of Sustainable Economies Management     Full-text available via subscription  
Investigación Económica     Open Access   (Followers: 4)
Investigaciones de Historia Económica     Open Access  
IQTISHADIA : Jurnal Ekonomi & Perbankan Syariah     Open Access  
Iqtishoduna : Jurnal Ekonomi Islam     Open Access  
Irish Economic and Social History     Hybrid Journal   (Followers: 12)
Islamic Economics Journal     Open Access  
Journal of Advanced Research in Economics and International Business     Full-text available via subscription  
Journal of Asian Development     Open Access   (Followers: 2)
Journal of Behavioral and Experimental Economics     Full-text available via subscription   (Followers: 11)
Journal of Chinese Economic and Foreign Trade Studies     Hybrid Journal   (Followers: 2)
Journal of Demographic Economics     Hybrid Journal   (Followers: 4)
Journal of Economic and Social Thought     Open Access   (Followers: 3)
Journal of Economic History     Full-text available via subscription   (Followers: 52)
Journal of Economic Issues     Hybrid Journal   (Followers: 14)
Journal of Economic Literature     Full-text available via subscription   (Followers: 188)
Journal of Economic Perspectives     Full-text available via subscription   (Followers: 217)
Journal of Economic Theory     Hybrid Journal   (Followers: 50)
Journal of Economics and International Relations     Open Access   (Followers: 4)
Journal of Ekonomi     Open Access  
Journal of Entrepreneurship in Emerging Economies     Hybrid Journal   (Followers: 4)
Journal of Governance and Regulation     Open Access  
Journal of Illicit Economies and Development     Open Access  
Journal of Innovation and Entrepreneurship     Open Access   (Followers: 7)
Journal of Islamic Economic Laws     Open Access  
Journal of Marketing Theory and Practice     Full-text available via subscription   (Followers: 3)
Journal of Post Keynesian Economics     Full-text available via subscription   (Followers: 13)
Journal of Public Economic Theory     Hybrid Journal   (Followers: 7)
Journal of Public Economics     Hybrid Journal   (Followers: 76)
Journal of Public Economics Plus     Open Access  
Journal of Quantitative Economics     Hybrid Journal  
Journal of Regional Economics Indonesia     Open Access  
Journal of Revenue and Pricing Management     Hybrid Journal   (Followers: 4)
Journal of Spatial Econometrics     Hybrid Journal  
Journal of Statistical and Econometric Methods     Open Access   (Followers: 3)
Journal of the Economic and Social History of the Orient     Hybrid Journal   (Followers: 21)
Journal of the History of Economic Thought     Full-text available via subscription   (Followers: 14)
Journal of Wine Economics     Full-text available via subscription   (Followers: 2)
Jurnal Economica : Research of Economic And Economic Education     Open Access   (Followers: 1)
Jurnal Ekonomi dan Bisnis Islam (Journal of Islamic Economics and Business)     Open Access  
Jurnal Ekonomi dan Pembangunan Indonesia     Open Access  
Jurnal Ekonomi Pembangunan : Kajian Masalah Ekonomi dan Pembangunan     Open Access  
Jurnal Ekonomi Syariah Teori dan Terapan     Open Access  
Jurnal Hukum dan Pembangunan Ekonomi     Open Access  
Jurnal Ilmu Ekonomi Terapan     Open Access  
Latin American Economic Review     Open Access   (Followers: 5)
Latin American Journal of Management for Sustainable Development     Hybrid Journal  
Madagascar Conservation & Development     Open Access   (Followers: 2)
Management of Sustainable Development     Open Access   (Followers: 4)
Marketing Theory     Hybrid Journal   (Followers: 15)
Mediations : Journal of the Marxist Literary Group     Open Access  
MediaTrend     Open Access  
Mises : Interdisciplinary Journal of Philosophy, Law and Economics     Open Access  
Modern Economy     Open Access   (Followers: 3)
Moneta e Credito     Open Access   (Followers: 1)
New Agenda : South African Journal of Social and Economic Policy     Full-text available via subscription  
OECD Journal : Economic Studies     Full-text available via subscription   (Followers: 17)
Organizations and Markets in Emerging Economies     Open Access   (Followers: 1)
Papeles de Europa     Open Access  
Pecvnia : Revista de la Facultad de Ciencias Económicas y Empresariales, Universidad de León     Open Access  
Perfil de Coyuntura Económica     Open Access  
Pittsburgh Papers on the European Union     Open Access   (Followers: 2)
Población y Desarrollo - Argonautas y caminantes     Open Access  
Population and Economics     Open Access   (Followers: 2)
Pro-fit     Open Access  
Proceedings of Voronezh State University. Series: Economics and Management     Open Access  
QA : Rivista dell’Associazione Rossi-Doria     Full-text available via subscription  
Quarterly Journal of Islamic Finance and Banking Studies     Open Access   (Followers: 2)
Regional Formation and Development Studies     Open Access  
Review of Behavioral Economics     Full-text available via subscription   (Followers: 6)
Review of Development and Change     Full-text available via subscription  
Review of Economic Studies     Hybrid Journal   (Followers: 187)
Review of Evolutionary Political Economy     Hybrid Journal  
Review of Keynesian Economics     Partially Free   (Followers: 9)
Revista Conjuntura Econômica     Open Access   (Followers: 2)
Revista de Economía del Caribe     Open Access  
Revista de Economía del Rosario     Open Access  
Revista de Historia Económica     Full-text available via subscription   (Followers: 1)
Revista de Historia Industrial. Economía y Empresa     Open Access  
Revista de Política Económica para el Desarrollo Sostenible     Open Access  
Revista Economía y Política     Open Access  
Revista Galega de Economia     Open Access  
Revista Gestão e Desenvolvimento     Open Access  
Revista Latinoamericana de Desarrollo Económico     Open Access  

        1 2 | Last

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Revista de Direito Econômico e Socioambiental
Number of Followers: 0  

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ISSN (Online) 2179-8214
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  • Forsythosides as essential components of Forsythia-based traditional
           chinese medicines used to treat inflammatory diseases and COVID-19

    • Authors: Christian Bailly
      Pages: 1 - 20
      Abstract: Christian Bailly
      World Journal of Traditional Chinese Medicine 2022 8(1):1-20
      The dried fruits of the plant Forsythia suspensa (Forsythia Fructus: Lianqiao in Chinese) are used in many herbal preparations to treat various diseases or the associated symptoms. Forsythia extracts contain phenylethanoid glycosides (PhGs) such as the forsythosides (Fst A-to-P). The leading products, Fst-A,-B and-F (arenarioside), can be found also in >90 other plants inventoried here. The pharmacological properties of Fst are reviewed, with emphasis on their anticancer, antiviral, and antibacterial activities, which essentially derive from their anti-inflammatory and antioxidant effects. Fst-B functions as a potential binder of the repressor protein Kelch-like ECH-association protein 1 (Keap 1), thus promoting the nuclear translocation of the transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) implicated in the subsequent activation of the production of antioxidant enzymes and repression of the oxidative stress. The regulation of the Nrf2/Heme oxygenase-1 pathway is the central piece of the multifaceted mechanism of action of Fst-A/B. Their prominent antioxidant and anti-inflammatory effects support the use of these compounds in different inflammation-related diseases and conditions, from sepsis to neuroprotection and many other pathologies discussed here. In addition, these properties contribute to the antiviral action of the compounds. Fst-A/B displays activities against the influenza A virus and different Fst-containing traditional Chinese medicinal (TCMs) have revealed beneficial effects to combat the current COVID-19 pandemic. The mechanisms whereby Fst-A/B could inhibit viral multiplication are discussed. PhGs likely contribute to the anti-COVID-19 activities reported with several TCM such as Shuang-Huang-Lian oral liquid, Lianhua-Qingwen capsules, and others. This review highlights the pharmacological profile of Fst and illustrates health benefits associated with the use of Forsythia Fructus.
      Citation: World Journal of Traditional Chinese Medicine 2022 8(1):1-20
      PubDate: Sat,29 Jan 2022
      DOI: 10.4103/wjtcm.WJTCM_36_21
      Issue No: Vol. 8, No. 1 (2022)
       
  • A review of the pharmacology, application, ethnopharmacology,
           phytochemistry, quality control, processing, toxicology, and
           pharmacokinetics of Paridis Rhizoma

    • Authors: Song-Tao Liu, Huan Yu, A-Jiao Hou, Wen-Jing Man, Jia-Xu Zhang, Song Wang, Xue-Jiao Wang, Sen-Wang Zheng, Xiao-Lin Su, Liu Yang
      Pages: 21 - 49
      Abstract: Song-Tao Liu, Huan Yu, A-Jiao Hou, Wen-Jing Man, Jia-Xu Zhang, Song Wang, Xue-Jiao Wang, Sen-Wang Zheng, Xiao-Lin Su, Liu Yang
      World Journal of Traditional Chinese Medicine 2022 8(1):21-49
      Paridis Rhizoma (PR) is also known as the flower with seven leaves and one branch, PR with golden thread, etc. It tastes bitter, numb, and slightly cold and has little poison. It is often used for the treatment of external skin infection, sore throat, snake bite, fall pain, frightening convulsion, and other diseases. PR has analgesic, sedative, anti-inflammatory, hemostatic, antitumor, antibacterial, antiviral, and renal and liver protective effects; inhibition of angiogenesis; immune regulation; and antioxidant and cardiovascular effects, and antifertility and anti-early pregnancy sperm killing effects. Steroidal saponins, β-ecdysone, polysaccharides, microelements, flavonoid glycosides, and amino acids were isolated from PR. In this paper, its pharmacology, application, ethnopharmacology, phytochemistry, quality control, toxicology, and pharmacokinetics were reviewed. This information suggests that we should focus on the development of new drugs related to PR, including specific ingredients, so as to make PR play a greater therapeutic potential. At the same time, attention should be paid to the rational use of PR resources to avoid excessive using, resulting in resource shortage. Therefore, we can carry out the research on the substitutes of PR, a large-scale planting of (Paridis Rhizoma) PR, and develop the same genus of PR and other resources. So far, great progress has been made in pharmacology and phytochemistry, especially in antitumor research, and many traditional uses have been confirmed and clarified by modern pharmacological research. However, there are few studies on the mechanism of its pharmacological action and few studies on processing. To develop new drugs in the future, more studies and experiments are still needed to prove the effect of PR and explore more new effects.
      Citation: World Journal of Traditional Chinese Medicine 2022 8(1):21-49
      PubDate: Sat,29 Jan 2022
      DOI: 10.4103/wjtcm.wjtcm_4_21
      Issue No: Vol. 8, No. 1 (2022)
       
  • Recent advances of traditional chinese medicine in the regulation of
           myocardial mitochondrial function

    • Authors: Shi-Yao Wan, Jin-Gui Hu, Yu Zhang, Bo-Yang Yu, Jun-Ping Kou, Fang Li
      Pages: 50 - 58
      Abstract: Shi-Yao Wan, Jin-Gui Hu, Yu Zhang, Bo-Yang Yu, Jun-Ping Kou, Fang Li
      World Journal of Traditional Chinese Medicine 2022 8(1):50-58
      Cardiovascular disease is a crucial disease threatening human health, and its mortality rate ranks first among Chinese residents. Myocardial mitochondrial dysfunction is the main cause of various heart diseases such as myocardial infarction, myocarditis, hypertrophic cardiomyopathy, and heart failure. In recent years, many studies have confirmed that traditional Chinese medicine (TCM) can be used to improve myocardial mitochondrial function and treat heart disease. The purpose of this review was to analyze the regulatory mechanism of myocardial mitochondrial function by summarizing the effect of TCM on cardiovascular disease.
      Citation: World Journal of Traditional Chinese Medicine 2022 8(1):50-58
      PubDate: Sat,29 Jan 2022
      DOI: 10.4103/wjtcm.wjtcm_78_20
      Issue No: Vol. 8, No. 1 (2022)
       
  • Engineered production of bioactive natural products from medicinal plants

    • Authors: Ozkan Fidan, Jie Ren, Jixun Zhan
      Pages: 59 - 76
      Abstract: Ozkan Fidan, Jie Ren, Jixun Zhan
      World Journal of Traditional Chinese Medicine 2022 8(1):59-76
      Plant natural products have been particularly important due to their use in food, cosmetic, and pharmaceutical industries. In particular, Traditional Chinese Medicine provides a precious potential for the discovery of bioactive natural products and development of novel modern medicines. However, the existing production methods for plant natural products such as chemical synthesis and plant extraction does not meet the current demand. Due to their environmental and economic concerns, engineered production of valuable natural products in microbial hosts has become an attractive alternative platform. This review covers the recent advances in the engineered production of plant natural products in microorganisms. A special focus was placed on the biotechnological production of plant-derived terpenoids, flavonoids, and alkaloids. Some successful examples of engineered production of plant natural products (or their precursors) such as artemisinin, paclitaxel, naringenin, quercetin, berberine, and noscapine are summarized. This clearly indicates that the engineered production method is a promising approach with various advantages over current methods.
      Citation: World Journal of Traditional Chinese Medicine 2022 8(1):59-76
      PubDate: Sat,29 Jan 2022
      DOI: 10.4103/wjtcm.wjtcm_66_21
      Issue No: Vol. 8, No. 1 (2022)
       
  • Integrated miRNA and mRNA analysis identified potential mechanisms and
           targets of qianggan extracts in preventing nonalcoholic steatohepatitis

    • Authors: Jie Huang, Meng Li, Wen-Jun Zhoua, Ze-Min Yao, Guang Ji, Li Zhang, Ming-Zhe Zhu
      Pages: 77 - 86
      Abstract: Jie Huang, Meng Li, Wen-Jun Zhoua, Ze-Min Yao, Guang Ji, Li Zhang, Ming-Zhe Zhu
      World Journal of Traditional Chinese Medicine 2022 8(1):77-86
      Objective: Qianggan (QG) extract is a patented traditional Chinese medicine that has been widely used for the clinical treatment of nonalcoholic steatohepatitis (NASH). However, its mechanism remains unclear. Methods: The efficacy of QG was evaluated in mice with methionine-and-choline-deficient diet-induced NASH by measuring serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase levels and by H and E staining of liver sections. Microarray and bioinformatics analyses were performed to obtain hepatic microRNA (miRNA) and mRNA expression profiles and to mine potential mechanisms and therapeutic targets. Furthermore, representative miRNA and mRNA expression levels were validated by quantitative real-time polymerase chain reaction (qRT-PCR). Results: QG extract significantly improved NASH. Twelve differentially expressed miRNAs and 1124 differentially changed mRNAs were identified as potential targets of QG extract. Integrated analysis detected 976 miRNA–mRNA regulatory pairs, and networks including 11 miRNAs and 427 mRNAs were constructed by Cytoscape. Hub nodes including miR-7050-5p, miR-212-3p, Bcl2l11, and Kras were filtered out. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses revealed that 427 mRNAs were enriched in pathways including apoptotic process, immune response, FoxO signaling pathway, and natural killer cell-mediated cytotoxicity. We also constructed a protein–protein interaction network with 254 nodes, and identified hub genes including Kras, Fasl, and Ncam1. Finally, the results of qRT-PCR were in good accordance with microarray data. Conclusion: This study identified important hub miRNAs and mRNAs involved in the mechanism of QG extract and which might provide potential therapeutic targets for patients with NASH.
      Citation: World Journal of Traditional Chinese Medicine 2022 8(1):77-86
      PubDate: Sat,29 Jan 2022
      DOI: 10.4103/wjtcm.wjtcm_48_21
      Issue No: Vol. 8, No. 1 (2022)
       
  • Interim analysis report of kuanxiong aerosol in improving angina and
           quality of life after percutaneous coronary intervention

    • Authors: Luo-Qi Lin, Bing-Xin Wu, Miao-Yang Lin, Qiu-Xiong Chen, Dan-Ping Xu
      Pages: 87 - 91
      Abstract: Luo-Qi Lin, Bing-Xin Wu, Miao-Yang Lin, Qiu-Xiong Chen, Dan-Ping Xu
      World Journal of Traditional Chinese Medicine 2022 8(1):87-91
      Objective: The objective is to observe the effect of Kuanxiong aerosol (KXA) on angina and the quality of life of patients after percutaneous coronary intervention (PCI). Materials and Methods: Six hundred patients with angina after PCI (AAP) were randomly assigned to an experimental group and a control group (n = 300 in each group) and received basic treatment with KXA or basic treatment (respectively) for 8 weeks. The Seattle Angina Questionnaire (SAQ) and visual analog scale (VAS) scores of the two groups during the screening period and five follow-up periods were compared. Results: A total of 179 patients were included in this interim report, including 85 in the experimental group and 94 in the control group. Among the five-dimensional scores of the SAQ, the improvement in the angina frequency and quality of life scores in the experimental group was better than those in the control group after treatment (P < 0.01), and the difference in scores of the remaining dimensions was not statistically significant (P > 0.01). The difference in VAS scores between the two groups was not statistically significant (P > 0.01). No obvious adverse reactions were observed between the two groups. Conclusions: KXA can reduce the frequency of AAP and improve patients' quality of life.
      Citation: World Journal of Traditional Chinese Medicine 2022 8(1):87-91
      PubDate: Sat,29 Jan 2022
      DOI: 10.4103/wjtcm.wjtcm_26_21
      Issue No: Vol. 8, No. 1 (2022)
       
  • Pharmacokinetic comparison of four major bio-active components of
           naoxintong capsule in normal and acute blood stasis rats using
           ultra-performance liquid chromatography coupled with triple-quadrupole
           mass spectrometry

    • Authors: Wei-Xia Li, Shu-Qi Zhang, Man-Man Li, Hui Zhang, Xiao-Yan Wang, Lu Niu, Jin-Fa Tang, Xue-Lin Li
      Pages: 92 - 99
      Abstract: Wei-Xia Li, Shu-Qi Zhang, Man-Man Li, Hui Zhang, Xiao-Yan Wang, Lu Niu, Jin-Fa Tang, Xue-Lin Li
      World Journal of Traditional Chinese Medicine 2022 8(1):92-99
      Objective: To compare the pharmacokinetic differences of the main components of Naoxintong capsule (NXTC) in normal and acute blood stasis rats. Materials and Methods: Rats were subcutaneously injected with adrenaline hydrochloride twice; during the two subcutaneous injections, the rats were placed in ice water for 4 min to reproduce the model rat of acute blood stasis. The normal and acute blood stasis rats were administrated a 5.04 g/kg dose of NXTC suspension. Then, blood samples were collected from the posterior retinal venous plexus at different time points. Plasma concentrations of four major bio-active components including caffeic acid, ferulic acid, formononetin, and tanshinone IIA in NXTC were measured using ultra-performance liquid chromatography coupled with triple-quadrupole mass spectrometry. Phoenix WinNonlin v6.2 software was used to calculate the pharmacokinetic parameters. Results: Compared with the normal rats, the acute blood stasis rats showed a significant decrease in Cmax of ferulic acid and formononetin, AUCall of caffeic acid and ferulic acid, and AUCINF_obs of ferulic acid. Conversely, an increase in the Vz_F_obs and MRTlast of ferulic acid and caffeic acid was observed. These findings demonstrate that the absorption of the four NXTC components was weakened in the acute blood stasis rats and that the elimination time was prolonged. Conclusions: The significant difference in some parameters of the four NXTC components between the normal and acute blood stasis rats might be caused by an increase in blood viscosity and the subsequent slowing down of blood flow in the acute blood stasis rats. The pharmacokinetic study conducted in pathological state can provide important information and scientific basis for further rational clinical application of NXTC.
      Citation: World Journal of Traditional Chinese Medicine 2022 8(1):92-99
      PubDate: Sat,29 Jan 2022
      DOI: 10.4103/wjtcm.wjtcm_53_21
      Issue No: Vol. 8, No. 1 (2022)
       
  • Network pharmacology-based study of the anti-oxidative mechanism of san
           miao wan in treatment of arthritis

    • Authors: Xue-Qin Hao, Yan-Qi Kou, Xiao-Juan Xie, Jiao-Wang, Jing-Bo Lv, Jie Su, Ke-Xin Liu, Gao-Feng Liang
      Pages: 100 - 109
      Abstract: Xue-Qin Hao, Yan-Qi Kou, Xiao-Juan Xie, Jiao-Wang , Jing-Bo Lv, Jie Su, Ke-Xin Liu, Gao-Feng Liang
      World Journal of Traditional Chinese Medicine 2022 8(1):100-109
      San Miao Wan (SMW) is a traditional Chinese medicine (composed of Cortex phellodendri, Rhizoma atractylodes, and Radix cyathulae) widely used in China to treat arthritis; however, its underlying mechanism remains unknown. We established the target gene library of SMW and performed gene ontology enrichment analysis of related target genes. The component-target protein-protein interaction (PPI) network of SMW and the disease-target PPI network of arthritis were merged to form a core PPI network. Finally, the anti-oxidative effect of SMW for treating arthritis was evaluated in a rat arthritis model induced by sodium urate. The results showed that R. atractylodes contained four active components with 68 target proteins, R. cyathulae contained two active components and 139 target proteins, and C. phellodendri contained eight active components and 275 target proteins. The target genes of R. cyathulae were highly related to the synthesis and metabolism of reactive oxygen species, while target genes of R. atractylodes and C. phellodendri were highly related to the circulatory system. The component-target PPI network of SMW and the disease-target PPI network of arthritis predominantly overlapped. In vivo, SMW effectively reduced knee swelling induced by sodium urate, decreased serum malondialdehyde levels, and increased serum superoxide dismutase levels. In conclusion, the therapeutic effects of SMW in arthritis are associated with its anti-oxidative properties.
      Citation: World Journal of Traditional Chinese Medicine 2022 8(1):100-109
      PubDate: Sat,29 Jan 2022
      DOI: 10.4103/wjtcm.wjtcm_46_21
      Issue No: Vol. 8, No. 1 (2022)
       
  • Herbal medicine teng-long-bu-zhong-tang inhibits the growth of human RKO
           colorectal cancer by regulating apoptosis, senescence, and angiogenesis

    • Authors: Meng-Meng Wei, Shuang-Shuang Wang, Jia-Lu Zheng, Lei Chen, Xiao Peng, Jin-Fang Chen, Hong-Mei An, Bing Hu
      Pages: 110 - 114
      Abstract: Meng-Meng Wei, Shuang-Shuang Wang, Jia-Lu Zheng, Lei Chen, Xiao Peng, Jin-Fang Chen, Hong-Mei An, Bing Hu
      World Journal of Traditional Chinese Medicine 2022 8(1):110-114
      Background: Teng-Long-Bu-Zhong-Tang (TLBZT) is a traditional Chinese herbal medicine used to treat colorectal cancer (CRC). In the present study, we observed the anti-cancer effects of TLBZT on human RKO CRC. Materials and Methods: Mice were subcutaneously transplanted with RKO cells, divided into control, 5-Fu-administered, TLBZT-administered, and TLBZT and 5-Fu combination-administered groups, and treated with 5-Fluorouracil (5-Fu) and/or TLBZT. Apoptosis was detected by TdT-mediated dUTP nick-end labeling assay. The activity of caspase-3,-8, and-9 was detected using specific commercial kits. Cell senescence was assessed using senescence β-galactosidase staining. Protein expression was evaluated by immunohistochemistry. Results: TLBZT inhibited RKO CRC tumor growth, enhanced the anti-cancer effects of 5-Fu, induced apoptosis, and activated caspase-3,-8, and-9. TLBZT induced cell senescence accompanied by the downregulation of cyclin E1 and cyclin-dependent kinase 2 expressions. TLBZT also inhibited angiogenesis and the expression of hypoxia-inducible factor 1 subunit alpha and vascular endothelial growth factor-A. Conclusions: TLBZT inhibited RKO CRC tumor growth and enhanced the anti-cancer effects of 5-Fu, and it could be associated with apoptosis and cell senescence induction, and angiogenesis inhibition.
      Citation: World Journal of Traditional Chinese Medicine 2022 8(1):110-114
      PubDate: Sat,29 Jan 2022
      DOI: 10.4103/wjtcm.wjtcm_42_21
      Issue No: Vol. 8, No. 1 (2022)
       
  • Quercetin-3-O-β-D-glucuronide inhibits mitochondria pathway-mediated
           platelet apoptosis via the phosphatidylinositol-3-kinase/AKT pathway in
           immunological bone marrow failure

    • Authors: Le-Min Xia, Ai-Ping Zhang, Qin Zheng, Jie Ding, Zhe Jin, Hai Yu, Wan-Hui Wong, He-Ping Yu
      Pages: 115 - 122
      Abstract: Le-Min Xia, Ai-Ping Zhang, Qin Zheng, Jie Ding, Zhe Jin, Hai Yu, Wan-Hui Wong, He-Ping Yu
      World Journal of Traditional Chinese Medicine 2022 8(1):115-122
      Objective: Quercetin-3-O-β-D-glucuronide (QG) can alleviate immunological bone marrow failure (BMF) by increasing platelet counts. However, the principal mechanism is less known. This study aimed at deciphering the possible underlying mechanism of QG that is indicated in thrombocytopenic purpura. Methods: In vitro and in vivo experiments were carried out for investigating the mechanism behind QG-facilitated inhibition of mitochondrial pathway-mediated excessive apoptosis of platelets through the phosphatidylinositol-3-kinase (PI3K)/AKT pathway. Results: Our results revealed that QG, the main effective ingredient of Herba Sarcandrae, increases the number of platelets and decreases the expression of Bax, Bad, Bid, and caspase-9 in immunological BMF, indicating the inhibition of mitochondrial pathway-mediated apoptosis. Moreover, we found that the protein and mRNA expressions, as well as the phosphorylated levels of PI3K and AKT, were increased significantly by QG, suggesting the activation of the PI3K/AKT pathway. Furthermore, the inhibition of the PI3K/AKT pathway by LY294002 antagonizes the effects of QG on platelet counts and mitochondrial pathway-mediated apoptosis. Conclusion: We demonstrate that QG inhibits the mitochondria pathway-mediated platelet apoptosis via the PI3K/AKT pathway in immunological BMF. This study thus sheds light on exploring the possible regulatory mechanism of traditional Chinese medicine in the treatment of thrombocytopenia induced by BMF.
      Citation: World Journal of Traditional Chinese Medicine 2022 8(1):115-122
      PubDate: Sat,29 Jan 2022
      DOI: 10.4103/wjtcm.wjtcm_44_21
      Issue No: Vol. 8, No. 1 (2022)
       
  • Effect of salivary antimicrobial factors on microbial composition of
           tongue coating in patients with coronary heart disease with phlegm-stasis
           syndrome

    • Authors: Juan Ye, Ke-Lei Su, Yue-Hua Xu, Yang Yang, Qian Zhou, Wei Gao, Xue-Ting Cai, Qing-Yu Wei, Meng Cao, Peng Cao
      Pages: 123 - 130
      Abstract: Juan Ye, Ke-Lei Su, Yue-Hua Xu, Yang Yang, Qian Zhou, Wei Gao, Xue-Ting Cai, Qing-Yu Wei, Meng Cao, Peng Cao
      World Journal of Traditional Chinese Medicine 2022 8(1):123-130
      Objective: Phlegm-stasis syndrome is one of the most common traditional Chinese medicine (TCM) syndromes and found in 59% of patients with coronary heart disease (CHD) in routine TCM clinical practice in China. One of the diagnostic criteria of phlegm-stasis syndrome is its characteristic white-greasy and thin tongue coating. We have previously reported that different types of tongue coating have different microbiome characteristics that can be used as diagnostic markers. However, the microbial characteristics of tongue coating of CHD patients with phlegm-stasis syndrome, including coating feature and underlying reason of formation, have rarely been reported. Herein, we examined the characteristic microbiome of tongue coating, and discussed the cause of tongue coating formation via salivary proteins in patients with phlegm-stasis syndrome. Methods: We examined white-greasy and thin tongue coatings obtained from 10 patients with CHD having phlegm-stasis syndrome (n = 10), and compared with those of patients with almost no coating – patients with Qi-Yin deficiency syndrome (n = 10) – and healthy controls (n = 10). 16S rRNA sequencing of tongue coating microbiome and isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative analysis of salivary proteins were used to detect tongue coating and salivary protein separately. Salivary levels of sIgA, lysozyme, and amylase were detected by ELISA. Results: We identified Candidatus_Saccharimonas and Candidate_division_TM7_norank as the prominent members of tongue coating in patients with CHD having phlegm-stasis syndrome. Salivary proteins involved in biological processes, pentose phosphate pathway, and complement and coagulation cascades were among the differentially expressed proteins identified in patients with CHD having phlegm-stasis syndrome on iTRAQ analysis. Moreover, the formation of microbiota in tongue coating was associated with salivary sIgA, lysozyme, and saliva flow rate. Conclusions: We explored the characteristics of microbial composition of tongue coating patients with CHD having phlegm-stasis syndrome and identified correlations between salivary proteins and microbiome formation, providing a theoretical and mechanistic basis for tongue coating formation.
      Citation: World Journal of Traditional Chinese Medicine 2022 8(1):123-130
      PubDate: Sat,29 Jan 2022
      DOI: 10.4103/wjtcm.wjtcm_34_21
      Issue No: Vol. 8, No. 1 (2022)
       
  • Mechanism exploration of the classical traditional chinese medicine
           formula huoluo xiaoling pill in clinical treatment and the traditional
           chinese medicine theory “treating different diseases with the same
           method”: A network pharmacology study and molecular docking
           verification

    • Authors: Yu-Xin Hu, Zhi-Qing Zhang, Qin-Jie Zhou, Jun-Ya Liao, Xin-Lou Chai
      Pages: 131 - 140
      Abstract: Yu-Xin Hu, Zhi-Qing Zhang, Qin-Jie Zhou, Jun-Ya Liao, Xin-Lou Chai
      World Journal of Traditional Chinese Medicine 2022 8(1):131-140
      Objective: To analyze the possible mechanism of the Huoluo Xiaoling Pill in the treatment of three diseases, hyperglycemia, hyperlipidemia, and metabolic syndrome, and to provide ideas for learning the mechanism of “Treating different diseases with the same method” in Traditional Chinese Medicine (TCM) theory. Materials and Methods: The Traditional Chinese Medicine System Pharmacology Database and UniProt databases were used to screen the main ingredients and targets of the Huoluo Xiaoling Pill. The GeneCards database was used to screen the targets of the diseases, and Cytoscape 3.7.2 was used to construct a “Drug-Components-Targets-Disease” network to determine the core components. The STRING database was used to construct the protein-protein-interaction network, and gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomics enrichment analyses were carried out on the Metascape database. AutoDock 1.5.6 was used for molecular docking. Results: A total of 118 active components and 208 targets were screened in the Huoluo Xiaoling Pill. Quercetin, tanshinone IIA, luteolin, and ellagic acid were potential core components of Huoluo Xiaoling Pill treating the three diseases, and interleukin 6, Tumor necrosis factor, and vascular endothelial growth factor were potential key targets. Co-occurring GO biological processes involved responses to the molecules of bacterial origin, and the AGE-RAGE signaling, fluid shear stress, and atherosclerosis pathways were the co-occurring pathways. Molecular docking revealed good docking conditions between screened targets and components. Conclusion: This study predicted the mechanism of the Huoluo Xiaoling Pill in treating the three diseases. At the same time, the co-occurring targets and pathways between the three diseases provided a material basis for the TCM theory, “Treating different diseases with the same method.”
      Citation: World Journal of Traditional Chinese Medicine 2022 8(1):131-140
      PubDate: Sat,29 Jan 2022
      DOI: 10.4103/wjtcm.wjtcm_58_21
      Issue No: Vol. 8, No. 1 (2022)
       
  • Ultra-performance liquid chromatography-quadrupole/time-of-flight mass
           spectrometry based bile and urine metabonomics study on the ameliorative
           effects of Curcuma wenyujin rhizoma on acute blood stasis in rats

    • Authors: Min Hao, Meng-Ting Zhao, Huang-Jin Tong, De Ji, Lin Li, Lian-Lin Su, Wei Gu, Chun-Qin Mao, Tu-Lin Lu
      Pages: 141 - 152
      Abstract: Min Hao, Meng-Ting Zhao, Huang-Jin Tong, De Ji, Lin Li, Lian-Lin Su, Wei Gu, Chun-Qin Mao, Tu-Lin Lu
      World Journal of Traditional Chinese Medicine 2022 8(1):141-152
      Background: Curcuma wenyujin rhizome (CWR) is a commonly used Chinese herbal medicine for treating blood stasis in China for 1000 of years. However, the underlying mechanism of CWR remains unclear. Aims and Objectives: The purpose of this study is to clarify the bioactive mechanism of CWR in treating blood stasis. Materials and Methods: In this study, pharmacological indexes, including hemorheology and four blood coagulation indexes were tested. Bile and urine metabolomics were engaged by UPLC-Q/TOF-MS. Multivariate statistical analysis were used to screen out differential endogenous metabolites. Results: The results indicated that CWR significantly ameliorated the hemorheology and coagulation functions of acute blood stasis (ABS) model rats. Moreover, 27 endogenous metabolites between the CWR group and the ABS group were screened, and the levels were all improved to certain degrees by CWR preadministration. Metabonomics results indicated that ABS was mainly related to linoleic acid metabolism, arachidonic acid metabolism, glycerophospholipid metabolism, sphingolipid metabolism, pentose and glucuronate intercereasonversions, steroid hormone biosynthesis, and primary bile acid biosynthesis. Conclusion: In a word, the metabolomics method is consistent with the holistic view of traditional Chinese medicine (TCM) that can be a powerful means to illustrate the biological activity mechanism of CWR in treating blood stasis and to offer research demonstration for further study on the effector mechanism of TCM.
      Citation: World Journal of Traditional Chinese Medicine 2022 8(1):141-152
      PubDate: Sat,29 Jan 2022
      DOI: 10.4103/wjtcm.wjtcm_55_21
      Issue No: Vol. 8, No. 1 (2022)
       
  • Therapeutics of integrative medicine ameliorate immunological disorders of
           the nervous system: A meta-analysis

    • Authors: Jin-Yun Ma, Jennifer Cruz, Jason Jin, Xiao-Yan Peng, Ai-Ming Zhang, Xiao-Dong Cheng
      Pages: 153 - 167
      Abstract: Jin-Yun Ma, Jennifer Cruz, Jason Jin, Xiao-Yan Peng, Ai-Ming Zhang, Xiao-Dong Cheng
      World Journal of Traditional Chinese Medicine 2022 8(1):153-167
      Objective: The objective of the study is to evaluate the therapeutic efficacy of integrative medicine in the treatment of immunological disorders of the nervous system. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were adopted to conduct this study, which included randomized controlled trials with a confirmed diagnosis of multiple sclerosis (MS), myasthenia gravis (MG), and Guillain–Barre syndrome (GBS), all of which were treated with integrative medicine. The effective rate, recurrent frequency, and disease score were used as the markers of outcome variables for the meta-analysis. Results: A total of 48 randomized control trials were included. The effective rates of treatment with integrative medicine were noticeably higher than those with Western medicine alone for the three diseases. The recurrence frequency for MS and the recurrence rate for MG treated with integrative medicine were reduced more than those with Western medicine alone. The Extended Disability Status Scale, acetylcholine receptor antibody, and Hughes scores for MS, MG, and GBS, respectively, treated with integrative medicine were significantly lower than those with Western medicine alone. The risks of bias in the literature evaluation showed that the quality of the included studies was not high. Conclusions: Compared to treatment with Western medicine alone, integrative medicine might ameliorate immunological disorders of the nervous system.
      Citation: World Journal of Traditional Chinese Medicine 2022 8(1):153-167
      PubDate: Sat,29 Jan 2022
      DOI: 10.4103/wjtcm.wjtcm_57_21
      Issue No: Vol. 8, No. 1 (2022)
       
 
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