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  Subjects -> SCIENCES: COMPREHENSIVE WORKS (Total: 374 journals)
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The Innovation
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2666-6758
Published by Elsevier Homepage  [2974 journals]
  • Novel microfluidic device for measurable residual disease detection in
           acute leukemia

    • Authors: Ziwei Cai; Shuang Fan, Xiaoyi Sun, Xiaodong Mo, Gen Yang
      Abstract: Relapse is the most important cause of treatment failure in acute leukemia (AL). Thus, how to predict relapse is critical for improving the survival of patients with AL. Measurable residual diseases (MRDs; previously termed minimal residual diseases), referring to the presence of remaining leukemia cells after the declaration of complete remission (CR) detected by morphological analysis, is the most important biomarker for relapse prediction.1 Several methods, including multiparameter flow cytometry (MFC), real-time quantitative polymerase chain reaction (qPCR), digital PCR (dPCR), and next-generation sequencing (NGS), are used to monitor MRD after treatment, reaching a sensitivity of 10−4 to 10−6.
      Citation: The Innovation 4, 3 (2023)
      PubDate: 2023-03-23
      DOI: 10.1016/j.xinn.2023.100408
      Issue No: Vol. 4, No. 3 (2023)
  • Targeted protein degradation in cancers: Orthodox PROTACs and beyond

    • Authors: Jin Li; Xinxin Chen, Aiping Lu, Chao Liang
      Abstract: Targeted protein degradation (TPD) is emerging as a strategy to overcome the limitations of traditional small-molecule inhibitors. Proteolysis-targeting chimera (PROTAC) technology can be used to target proteins by hijacking the ubiquitin-proteasome system. Conceptually, PROTAC aims to target the “undruggable” majority of proteins in the human proteome. Through constant exploration and optimization of PROTACs and the exploitation of other TPD strategies over two decades, TPD has expanded from theoretical studies to clinical strategies, with practical applications in oncological, immunological, and other diseases.
      Citation: The Innovation 4, 3 (2023)
      PubDate: 2023-03-15
      DOI: 10.1016/j.xinn.2023.100413
      Issue No: Vol. 4, No. 3 (2023)
  • Breakthroughs in projection-enabled additive manufacturing: From novel
           strategies to cutting-edge applications

    • Authors: Yu-Qing Liu; Zheng Xiong, Yong-Lai Zhang, Hua Liu
      Abstract: As one of the crucial technologies of additive manufacturing (AM), projection technology, which features fast printing speed, high molding accuracy, and low cost, exhibits great potential in cutting-edge applications. The basic principle of projection-enabled AM (PAM) is the stacking of layer-wise structures, in which the dynamic mask pattern is projected onto the surface of the liquid photosensitive resin, triggering polymerization in a specific area to accomplish single-layer printing. This facilitates the layer-wise manufacture of complex three-dimensional (3D) structures.
      Citation: The Innovation 4, 3 (2023)
      PubDate: 2023-02-27
      DOI: 10.1016/j.xinn.2023.100395
      Issue No: Vol. 4, No. 3 (2023)
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