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  Subjects -> SCIENCES: COMPREHENSIVE WORKS (Total: 374 journals)
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AAS Open Research
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2515-9321
Published by African Academy of Sciences Homepage  [1 journal]
  • Biobanking in East and Central Africa: A case of the Integrated
           Biorepository of H3Africa Uganda [version 1; peer review: awaiting peer

    • Authors: Gideon Nsubuga, David Patrick Kateete, Sharley Melissa Aloyo, Lwanga Newton Kigingi, Nasinghe Emmanuel, Kezimbira Dafala, Moses Levi Ntayi, Moses L Joloba, Kamulegeya Rogers
      Abstract: Biorepositories are essential because they guarantee the proper storage and distribution of biospecimens and their associated data for current and future research. In Eastern and Central Africa, the Integrated Biorepository of H3Africa Uganda (IBRH3AU) at Makerere University in Uganda was the first of its kind. It is strategically located at Makerere University College of Health Sciences, which is home to some of Uganda's most relevant and impactful infectious and non-infectious disease research.  Since its inception as a pilot project in 2012, the IBRH3AU biorepository has grown into a state-of-the-art facility serving the H3Africa consortium and the rest of the scientific community. IBRH3AU has built a solid infrastructure over the past ten years with cutting-edge methods and technologies for the collection, processing, quality control, handling, management, storage and shipment of biospecimens. H3Africa researchers, local researchers, postgraduate and postdoctoral students, and the greater scientific community in Eastern and Central Africa and beyond have benefited from IBRH3AU's exceptional biobanking services.
      PubDate: 2022-09-30T08:21:57Z
      DOI: 10.12688/openresafrica.13495.1
      Issue No: Vol. 5 (2022)
  • Barriers and facilitators to maternal death surveillance and response at a
           busy urban National Referral Hospital in Uganda [version 1; peer review:
           awaiting peer review]

    • Authors: Imelda Namagembe, Jolly Beyeza-Kashesya, Joseph Rujumba, Dan K.Kaye, Moses Mukuru, Noah Kiwanuka, Ashley Moffett, Annetteee Nakimuli, Josaphat Byamugisha
      Abstract: Background: Preventable maternal and newborn deaths remain a global concern, particularly in low- and middle-income countries. Timely maternal death surveillance and response (MDSR) is a recommended strategy to account for such deaths through identifying contextual factors that contributed to the deaths to inform recommendations to implement in order to reduce future deaths. With the leadership of WHO and UNFPA, there is momentum to roll out MDSR, however, the barriers and enablers for implementation have received limited attention. These have important implications for successful implementation. The aim of this study was: To assess barriers and facilitators to implementation of MDSR at a busy urban National Referral Hospital as perceived by health workers, administrators, and other partners in Reproductive Health. Methods: Qualitative study using in-depth interviews (24), 4 focus-group discussions with health workers, 15 key-informant interviews with health sector managers and implementing partners in Reproductive-Health. We conducted thematic analysis drawing on the Theory of Planned Behaviour (TPB).   Results: The major barriers to implementation of MDSR were: inadequate knowledge and skills; fear of blame and litigation; failure to implement recommendations; burn out because of workload at the National Referral Hospital and inadequate leadership- to support health workers. Major facilitators were involving all health workers in the MDSR process, eliminate blame, strengthen leadership, implement recommendations from MDSR and functionalize lower health facilities (especially Health Centre -IVs). Conclusions: The barriers of MDSR include knowledge and skills gaps, fear of blame and litigation, and other health system factors such as erratic emergency supplies, and leadership/governance challenges. Efforts to strengthen MDSR for impact should use health system responsiveness approach to address the barriers identified, constructive participation of health workers to harness the facilitators and addressing the required legal framework.
      PubDate: 2022-09-14T09:26:04Z
      DOI: 10.12688/openresafrica.13438.1
      Issue No: Vol. 5 (2022)
  • No association between fertility desire and HIV infections among men and
           women: Findings from community-based studies before and after
           implementation of an early antiretroviral therapy (ART) initiation program
           in the rural district of North-western Tanzania [version 1; peer review:
           awaiting peer review]

    • Authors: Denna Mkwashapi, Jim Todd, Michael Mahande, John Changalucha, Mark Urassa, Milly Marston, Jenny Renju
      Abstract: Background: Fertility is associated with the desire to have children. The impacts of HIV and antiretroviral therapy (ART) on fertility are well known, but their impacts on the desire for children are less well known in Tanzania. We used data from two studies carried out at different periods of ART coverage in rural Tanzania to explore the relationship between HIV infection and fertility desires in men and women. Methods: We conducted secondary data analysis of the two community-based studies conducted in 2012 and 2017 in the Magu Health and Demographic system site, in Tanzania. Information on fertility desires, HIV status, and social–economic and demographic variables were analyzed. Fertility desire was defined as whether or not the participant wanted to bear a child in the next two years. The main analysis used log-binomial regression to assess the association between fertility desire and HIV infection. Results: In the 2012 study, 43% (95% CI 40.7-45.3) of men and 33.3% (95% CI 31.8 - 35.0) women wanted another child in the next two years. In 2017 the percentage rose to 55.7% (95% CI 53.6 - 57.8) in men and 41.5% (95% CI 39.8 - 43.1) in women. Although fertility desire in men and women were higher in HIV uninfected compared to HIV infected, age-adjusted analysis did not show a statistical significance difference in both studies (2012: PR=1.02, 95%CI 0.835 - 1.174, p
      PubDate: 2022-09-14T09:15:39Z
      DOI: 10.12688/openresafrica.13432.1
      Issue No: Vol. 5 (2022)
School of Mathematical and Computer Sciences
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