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  Subjects -> SCIENCES: COMPREHENSIVE WORKS (Total: 374 journals)
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Adıyaman University Journal of Science
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  This is an Open Access Journal Open Access journal
ISSN (Print) 2147-1630 - ISSN (Online) 2146-586X
Published by Adıyaman Üniversitesi Homepage  [3 journals]
  • Interstitial and Phytal Harpacticoid (Copepoda, Harpacticoida) Fauna of
           the Mediolittoral Zone of the Biga Peninsula (Çanakkale, Turkey)

    • Authors: Alper KABACA; Serdar SAK, Alp ALPER
      Abstract: In this study, interstitial and phytal harpacticoid copepods distributed along the mediolittoral zone of the Biga Peninsula were investigated. The samplings were made from 26 different stations seasonally between April - 2016, February - 2017. As a result, 73 species and subspecies belonging to 46 genera within 17 families were identified. In addition, 4 genera (Troglophonte, Psammastacus, Stereoxiphos and Pteropsyllus) and 20 species/subspecies (Ameira divagans, Ameira reducta, Filexilia intermedia, Nitokra sewelli, Noodtiella enertha, Noodtiella intermedia, Noodtiella wellsi, Glabrotelson sp., Asellopsis intermedia, Echinolaophonte minuta, Heterolaophonte brevipes, Klieonychocamptus klei confluens, Troglophonte sp., Psammastacus confluens, Stereoxiphos operculatus, Schizopera minuta, Emertonia constricta orotavae, Thalestrella sp., Phyllopodopsyllus berrieri and Pteropsyllus plebeius furcatus) are new records for the Turkish fauna. Besides, all identified taxa are new records for the Biga Peninsula.
      PubDate: Thu, 30 Jun 2022 00:00:00 +030
  • Effects of Copper Substitution to Mn-site on Magnetic and Magnetocaloric
           Properties of La0.7Sr0.3Mn1-xCuxO3 Manganites

    • Authors: Selda KILIÇ ÇETİN; Gönül AKÇA, Mehmet Selim ASLAN, Ahmet EKİCİBİL
      Abstract: In present study, the effects of copper substitution on the magnetic and magnetocaloric properties of La0.7Sr0.3Mn1-xCuxO3 manganite samples were investigated. La0.7Sr0.3Mn1-xCuxO3 samples were obtained by using sol-gel method. X-ray diffraction analyses were performed to determine structural properties such as lattice parameters and crystal structure. The crystal structure of the samples is rhombohedral with space group 𝑅3𝑐. The Cu substitution to the Mn- site causes a decrease in the magnetic phase transition temperature (TC) of the samples. By using Banerjee criterion and Landau theory, the type of magnetic phase transition is determined as second order. From isothermal magnetization measurements, magnetic entropy change (-∆𝑆() values were calculated for different magnetic field changes of the samples. The maximum magnetic entropy change value (-∆𝑆(*+,) determined from the temperature dependence of -∆𝑆( curves for the samples is 3.39 and 2.78 JKg-1K-1 under 5 T, respectively. Relative cooling power (RCP) values of the samples were found as 249.52 and 111.98 Jkg-1 for 5 T, respectively.
      PubDate: Thu, 30 Jun 2022 00:00:00 +030
  • Evaluation of Some Sulfonamide Derivatives as a Potential Inhibitors of
           The Carbonic Anhydrase IX/XII by ADME and Molecular Docking Method

    • Authors: Nuri YORULMAZ; Hilal ÖZTÜRK, Mustafa DURGUN
      Abstract: Molecular docking is a simulation technique that calculates the binding score of the molecules of interest to protein structures and visualizes the bond structure. It is a widely used technique for foresight because it helps to determine bond relationships between molecular structures before laboratory applications in the development of new drugs. ADME studies also provide clues for the determination of the molecules analyzed by the molecular docking method to be drug candidates. In this study, inhibition of CA IX and CA XII enzymes by sulfonamide derivatives synthesized in our previous study was investigated using molecular docking method. The CA enzyme family has an important role in the survival and spread of cancer cells. Therefore, we aimed to find new drug candidates that inhibit these enzymes. We found that the sulfonamide derivative named 6 binds to the active sites of both CA IX and CA XII enzymes with -7.44 kcal/mol and -6.39 kcal/mol energy, respectively, closest to the binding of the reference molecule acetazolamide. In addition, the compatibility of all compounds used in the study with drug-like properties was investigated using the ADME method. In conclusion, it can be said that the sulfonamide derivatives named 1-9 generally have the characteristic features of a drug (physicochemical and structural properties) and oral bioavailability.
      PubDate: Thu, 30 Jun 2022 00:00:00 +030
  • Microbiological Investigation of the Effects of Olanzapine with
           Thymoquinone on the Intestine

    • Authors: Ayşe Nilay GÜVENÇ; Sebile AZİRAK, Deniz TAŞTEMİR KORKMAZ, Sedat BİLGİÇ, Nevin KOCAMAN, Mehmet Kaya ÖZER
      Abstract: The aim of our study is to examine the effect of thymoquinone (TQ) in obese rats induced with the antipsychotic drug olanzapine (OL). Thirty-five female Spraque-Dawley rats were divided into five groups (n = 7): Control, OL (2 mg / kg OL daily), OL + TQ1 (2 mg / kg OL + 20 mg / kg TQ), OL + TQ2 (2 mg / kg OL + 40 mg / kg TQ) and the OL + TQ3 group (2 mg / kg OL + 80 mg / kg TQ). On the 15th day of treatment, intestinal tissue was removed for analysis. It has been found that TQ treatment affects the levels of Firmicutes and Bacteroides at varying rates in the intestinal flora in OL + TQ1, OL + TQ2, and OL + TQ3 groups, and also has a significant role in the apoptotic effect of TQ. In conclusion, with this study, it was determined that the treatment of TQ has a protective property against the side effects of OL. TQ can be an effective treatment method to increase therapeutic effectiveness.
      PubDate: Thu, 30 Jun 2022 00:00:00 +030
  • New Weyl-Type Inequalities by Multiplicative Injective and Surjective
           s-Numbers of Operators in Reflexive Banach Spaces

    • Authors: Lale CONA
      Abstract: In this work, two problems are investigated. In general, Weyl-type inequalities of operators in complex reflexive Banach spaces are discussed. First, we obtained the Weyl-type inequalities using arbitrary multiplicative surjective and injective 𝑠-numbers that are dual of each other. Second, we introduced the Weyl-type inequalities by multiplicative injective and surjective 𝑠- numbers under certain conditions for 𝑆 and 𝑆^' operators in complex reflexive Banach space. So, new Weyl-type inequalities are investigated for both dual 𝑠-number sequences and dual operators.
      PubDate: Thu, 30 Jun 2022 00:00:00 +030
  • Effects of FOLFIRINOX Components on Pancreatic Adenocarcinoma Cells

    • Authors: Sevde ALTUNTAS; Kübra Nur GÖKDEMİR
      Abstract: Pancreatic adenocarcinoma is one of the lethal types of cancer worldwide. This study aimed to evaluate the cytotoxic effects of FOLFIRINOX compounds [oxaliplatin (OXA), irinotecan (IRI), fluorouracil (5FU), and leucovorin (LEU)] on a pancreatic adenocarcinoma cell line (PANC-1), both individually and collectively. Cell viability was determined using the colorimetric MTT reagent and apoptosis was assessed using the propidium iodide – Hoechst 33342 staining assay. Based on cell viability data, 5FU and FOLFIRINOX treatments were more potent against PANC-1 than the other test groups. The apoptotic trend, nevertheless, was not different between them and the control group. Moreover, OXA, LEU, and IRI significantly increase apoptotic cell death. Our findings indicate that 5FU and FOLFIRINOX are comparably effective in reducing the PANC-1 cell viability. In the future, 5FU and FOLFIRINOX may be adapted to local pancreatic adenocarcinoma treatments, but the development of these localized drug release platforms requires further attention as the microenvironment of pancreatic adenocarcinoma inherently contains many unknowns.         
      PubDate: Thu, 30 Jun 2022 00:00:00 +030
  • The Anatomical Surveys on the Two Salvia L. Species (Sect. Hymenosphace,
           Sect. Hemisphace) Spreading in Mardin (Turkey)

    • Authors: Murat KILIÇ; Fatma MUNGAN KILIÇ
      Abstract: In this study, we investigated two Salvia species (sect. Hymenosphace, sect. Hemisphace) distributed in the province of Mardin in the Southeastern Anatolia Region in terms of anatomy. These species are S. multicaulis Vahl. (sect. Hymenosphace) and S. russellii Benth. (sect. Hemisphace). For anatomical investigation, cross-sections taken from roots, stems, leaves, and petioles of the taxa were examined under a light microscope. In anatomical examinations, it was observed that root, stem, leaf, and petiole structures of the taxa were similar but shapes and measurements as well as the the number of tissue layers and pith rows were different. In addition, it was observed that the surface of the S. multicaulis species was covered by multicellular and compound hairs. In conclusion, anatomical characters provide information of taxonomic importance, and especially hairiness is important in species differentiation.
      PubDate: Thu, 30 Jun 2022 00:00:00 +030
  • On Two Efficient Numerical Schemes for Nonlinear Burgers’ Type

    • Authors: Bilge INAN
      Abstract: In this work, we investigate two finite difference schemes to solve for nonlinear Burgers’ type equations. In the first stage, we define the numerical methods to solve the equations. Secondly, numerical solutions are obtained and compared with the exact solutions. In comparison with other defined results in the literature, it is deduced in a conclusive way that the methods are reliable and convenient alternative methods for solving for nonlinear Burgers’ type equations.
      PubDate: Thu, 30 Jun 2022 00:00:00 +030
  • Direct Product of Bitonic Algebras

    • Authors: Şule AYAR ÖZBAL
      Abstract: The purpose of this study is to construct the concept of direct product of bitonic algebras, and investigate some respective features. Also, the concept of direct product of commutative bitonic algebras, bitonic homomorphism are studied. Then the notion of direct product of bitonic algebras is expanded to finite family of bitonic algebras and their qualifications are practised.
      PubDate: Thu, 30 Jun 2022 00:00:00 +030
  • A New Schiff Base Molecule Prepared from Pyrimidine-2-thione: Synthesis,
           Spectral Characterization, Cytotoxic Activity, DFT, and Molecular Docking

    • Authors: Zülbiye KÖKBUDAK; Burçin TÜRKMENOĞLU, Senem AKKOÇ
      Abstract: Schiff base derivatives are some of the most widely used organic compounds for industrial purposes and they exhibit a broad range of biological activities. In this paper, a new Schiff base derivative (2) synthesized from the condensation reaction of 1-amino-5-benzoyl)-4- phenylpyrimidine-2(1H)-thione (1) with 2-chlorobenzaldehyde. The new compound was characterized by 1H, 13C NMR, and FT-IR. The biological activity property of this compound was tested against two different cancer cell lines and a healthy human cell line. The results demonstrate that molecule 2 has antiproliferative activity. In molecular modeling studies, the interaction site was examined using the epidermal growth factor receptor (EGFR) tyrosine kinase domain. Alignment in molecular docking, surface mapping binding, amino acids, and binding energy calculated. Glide score energy was found to be -9.820 kcal/mol and it predicted that the bonding interaction is strong. Theoretical calculations were made to compare the experimental and theoretical data. These calculations were performed on the 6–31 G* basis set using the Density Functional Theory (DFT) method and Becke-3-Parameter-Lee-Yang-Parr (B3LYP). Using this method, various parameters, such as frontier molecular orbitals, HOMO-LUMO energy levels, band gap, and chemical reactivity indices were found and interpreted.
      PubDate: Thu, 30 Jun 2022 00:00:00 +030
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