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  Subjects -> SCIENCES: COMPREHENSIVE WORKS (Total: 374 journals)
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Middle East Journal of Science
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2618-6136
Published by DergiPark Homepage  [183 journals]
  • EXPRESSION PATTERN OF BK CHANNELS ON VARIOUS OXIDATIVE STRESS CONDITIONS
           IN SKELETAL MUSCLE

    • Authors: Çağıl COŞKUN; Figen Amber ÇİÇEK, Onur TOKGÜN, Işıl ÖCAL
      Abstract: BK (large conductance Ca2+-activated potassium) channels are expressed in myocytes though changes in their molecular levels in the presence of oxidative stress is not clear, yet. Excessive production of reactive oxygen species leads to many diseases including periodic paralysis. Therefore, determination the molecular effects of various oxidative stress conditions may reveal the possible mechanism and potential therapeutic effects. In the present study, isolated rat soleus muscle where KCNMA1 genes encoding BK channel protein expressed widely in skeletal muscle, were exposed to cyclopiazonic acid (CPA) and also hydrogen peroxide (H2O2) as oxidative stress inducers. Streptozotocin-induced diabetes mellitus model was also used to demonstrate the effects of the endogenous source of oxidative stress. Moreover, NS1619, a BK channel opener was used whether the activation of the channel re-regulate the channel expression back. After the incubation periods, KCNMA1 gene expression levels of each groups were determined by real-time PCR experiments. While CPA and H2O2 decreased the KCNMA1 expression significantly, its expression did not change in systemic diabetes mellitus condition. However, the transcriptional level significantly decreased in diabetes in the presence of H2O2. On the other hand, KCNMA1 expression was re-regulated back to the control’s level by addition of NS1619 in solely hydrogen peroxide groups. The results demonstrated for the first time that acute oxidative stress, rather than systemic conditions, effects the KCNMA1 gene expression level in skeletal muscle. The study was also showed the effects of NS1619 on the regulation of transcriptional levels of BK channel protein in hydrogen peroxide conditions.
      PubDate: Fri, 17 Jun 2022 00:00:00 +030
       
  • MODELLING OF THE SOLAR CELL BASED ON Cu2SnS3 THIN FILM PRODUCED BY SPRAY
           PYROLYSIS

    • Authors: Serap YİĞİT GEZGİN; İlhan CANDAN, Şilan BATURAY, Hamdi Şükür KILIÇ
      Abstract: Cu2SnS3 (CTS) thin film has been produced for 30 ccm sulphur flux rate at 30 minutes annealing durations at 550 oC temperature. CTS thin film’s crystalline structure has been investigated and crystalline size, lattice parameters, dislocation density and microstrain, crystalline number have also been determined. The CTS thin film’s morphological and optical properties have been examined and thoroughly interpreted. Mo/CTS/CdS/AZO solar cell has been modelled based on CTS thin film produced at the present work, using SCAPS-1D simulation programme. Voc, Jsc, FF, conversion efficiency and photovoltaic parameters have been determined depending on neutral defect density at the interface, coefficient of radiative recombination, Auger electron/hole capture’s coefficient and operation temperature of CTS solar cell. As a consequence of simulation study, ideal efficiency of CTS solar cell has been determined to be 3.72 % and all the data obtained in this study have been presented, interpreted and concluded to be original results.
      PubDate: Fri, 17 Jun 2022 00:00:00 +030
       
  • INVESTIGATION OF GLOBOZOOSPERMIA’S MORPHOLOGICAL STRUCTURE AND DNA
           FRAGMENTATION IN OLIGOZOOSPERMIA CASES IN INFERTILE MALES

    • Authors: Zuhal ÇANKIRI; Murat AKKUŞ, Eda YİLDİZHAN, Dilara AKINCI, Fırat AŞIR, Onur DEDE, Muhamet AFŞİN
      Abstract: Total globozoospermia is diagnosed by the presence of 100% round-headed spermatozoa without acrosomes. It is still unclear whether patients whose ejaculate contains both normal and globozoospermic cells (partial globozoospermia) suffer from a variation of the same syndrome. Affected men may experience decreased fertility and even infertility. In some cases, an increased number of cells with DNA fragmentation has also been observed in patients with globozoospermia..In this study, standard semen analysis methods in accordance with WHO criteria were applied to infertile male patient groups consisting of 20 normozoospermic and 20 oligozoospermic individuals who were admitted to our clinic. Age, sperm parameters (volume, vitality, concentration, total motility and morphology) were determined and statistically analyzed in normozoospermic and oligozoospermic infertile men.Sperms were stained with the Eosin-Nigrosin method and were visualized under an immersion lens light microscope and evaluated for vitality. The slides were stained using sperm staining solutions with the Spermac technique and the sperms were evaluated morphologically. Sperm DNA fragmentation damage was evaluated by acridine orange staining method.Our results revealed that sperm morphological features (Kruger test) and sperm DNA fragmentation, obtained with various staining techniques, are important in the clinical approach to male infertility and ART methods, and should be used together.
      PubDate: Fri, 17 Jun 2022 00:00:00 +030
       
  • CHARACTERIZATION OF CU2MNSNS4 THIN FILMS FABRICATED BY SPIN COATING

    • Authors: Canan AYTUĞ AVA; Şilan BATURAY
      Abstract: Cu2MnSnS4 (CMTS) thin films are affected by several parameters related to different annealing including sulphurization flux rate. In this paper, nontoxic CMTS samples were fabricated onto glass substrate by a spin-coating to investigate the effect of various sulphurization flux rate on the crystal structure, tophological and optical properties by X-Ray diffraction, scanning electron microscopy, atomic force microscopy and ultraviolet–visible spectrophotometer, respectively The crystal properties of CMTS thin films are radically changed depending on increase of sulphurization flux rate annealed at 550 °C for 90 minutes. The XRD pattern give CMTS peaks at (112) plane for two samples which correspond to structure of kesterite crystal. The SEM images of films show a decrease in the particle size relate to increase flux rate of sulphurization. The energy band gap for the CMTS films are found to be 1.22 and 1.15 eV for 30 sccm and 40 sccm sulphurization flux rate annealed at 550 °C, respectively.
      PubDate: Fri, 17 Jun 2022 00:00:00 +030
       
  • NOVEL MONONUCLEAR METAL-PHOSPHINITE COMPOUNDS AND CATALYTIC PERFORMANCE IN
           TRANSFER HYDROGENATION OF KETONES

    • Authors: Uğur IŞIK; Nermin MERİÇ, Murat AYDEMİR
      Abstract: Since the obtained chiral alcohols are rather useful as well as biologically active compounds, reduction of ketones to their respective alcohols is a crucial topic in synthetic chemistry. Thus, a new phosphinite ligand was synthesized by the interaction of cationic species N-vinyl imidazolium (1) with PCy2Cl. This phosphinite ligand in combination with [Ru(η6-p-cymene)(µ-Cl)Cl]2 and Ir(η5-C5Me5)(μ-Cl)Cl]2 gave active catalytic systems for transfer hydrogenation reaction. Under optimum circumstances, ruthenium complex (3) showed rather high conversion reduction reaction of acetophenone. Reversibility of the transfer hydrogenation reaction was found to be low under these reaction circumstances.
      PubDate: Fri, 17 Jun 2022 00:00:00 +030
       
  • REVERSE-ENGINEERED DBI-ESSENCE FIELD IN THE RAINBOW GRAVITY

    • Authors: Fatma Figen BİNBAY
      Abstract: The current astrophysical data sets have implied that our universe has recently entered in an accelerated expansion phase. In literature, it is commonly thought that the late-time speedy enlargement behaviour is caused by mysterious dark contents (dark matter, dark energy and dark radiation) that cannot be observed directly. Although Einstein's General Theory of Relativity has provided very successful theoretical explanations and predictions, it cannot explain the aforementioned unusual nature of the cosmos. This situation has led scientists to try to create a new theoretical model for the nature of dark contents. The cosmological constant, scalar fields, unified energy densities, additional dimension idea and modified gravity theories are among the prominent point of views. In this research, mainly, the reverse-engineering method is taken into account in the rainbow gravity formalism for the DBI-essence scalar field dark energy model. As it is known, scalar field models can be introduced with the help of some fundamental physics theories, but these theories do not provide a direct way to write explicitly the self-interaction potentials that we encounter in scalar field models. Therefore, the reverse-engineering method used in this research takes significant role while writing the self-interaction potential of a scalar field model.
      PubDate: Fri, 17 Jun 2022 00:00:00 +030
       
  • DFT INVESTIGATION OF TRANSTION METALS ARENE COMPOUNDS WITH FUNCTIONALIZED
           IONIC LIQUID

    • Authors: Nermin MERİÇ; Nil ERTEKİN BİNBAY, Veysel BİNBAY, Cezmi KAYAN, Murat AYDEMİR
      Abstract: Electrochemical properties and theoretical DFT computations have been carried out for the cationic parts of complexes of ionic liquid-based phosphinite, (1A-3A). The effects of the chemical structures of cationic parts of three complexes were examined in relation to the variable property of electron-donating ligands for ruthenium and iridium complexes were determined. Their potential energy surfaces in the ground state, electronic densities, and also frontier orbitals HOMO and LUMO have been obtained via DFT calculations.
      PubDate: Fri, 17 Jun 2022 00:00:00 +030
       
 
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