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Middle East Journal of Science
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2618-6136
Published by DergiPark Homepage  [187 journals]
  • TIME SERIES OUTLIER ANALYSIS FOR MODEL, DATA AND HUMAN-INDUCED RISKS IN
           COVID-19 SYMPTOMS DETECTION

    • Authors: Ahmet KAYA; Rojan GÜMÜŞ, Ömer AYDIN
      Abstract: Information systems are important references aiming to support the decisions of decision-makers. Information reliability depends on the accuracy and efficacy of data and models. Therefore, some risks may emerge in information systems concerning models, data and humans. It is important to identify and extract outliers in decision support systems developed for the health information systems such as the detection system of Covid-19 symptoms. In this study, the risks that are important in decision making in Covid-19 symptom detection were determined by the statistical time series (ARMA) approach. Potential solutions are proposed in this way. Moreover, outliers are detected by software developed by using the Box-Jenkins model and reliability and accuracy of data is increased by using estimated data instead of outliers. In the implementation of this study, time-series-based data obtained from laboratory examinations of Covid-19 test devices can be used. With the method revealed here, outliers originating from healthcare workers or test apparatus can be detected and more accurate results can be obtained by replacing these outliers with estimated values.
      PubDate: Thu, 30 Dec 2021 00:00:00 +030
       
  • SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF ESTER DERIVATIVES
           OF 4-(DIETHYLAMINO)SALICYLALDEHYDE AS CHOLINESTERASE, AND TYROSINASE
           INHIBITORS

    • Authors: Reşit ÇAKMAK; Ercan ÇINAR, Eyüp BAŞARAN, Mehmet BOĞA
      Abstract: Alzheimer's Disease (AD), one of the diseases that still has no a specific therapy, has become a major public health issue owing to the increasing population of the elderly, particularly in rich countries. Inhibitory of cholinesterase enzymes (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), which hydrolyze acetylcholine (ACh) and butyrylcholine (BCh) neurotransmitters, have recently become a choice for therapy of this disease. Therefore, there is currently a great demand for novel enzyme inhibitors with desirable properties for applying in the treatment of AD. A series of ester derivatives of 4-(diethylamino)salicylaldehyde 1-5 were successfully prepared in present work, and structurally illuminated with FT-IR, 1H and 13C NMR spectroscopy. The inhibition properties of the title molecules on AChE, BChE, and tyrosinase enzymes were extensively investigated, respectively. Compound 1 indicated potent inhibitory properties against BChE with 87.28±0.87% inhibition better than galantamine (73.83±0.25 %inhibition) employed as standard. Compound 3 showed potent inhibitory effect against tyrosinase with 87.73±0.22 % inhibition, which are better than kojic acid utilized as standard. The obtained results clearly revealed that some of these enzyme inhibitors have the potential to be utilized as potent enzyme inhibitors in the future.
      PubDate: Thu, 30 Dec 2021 00:00:00 +030
       
  • IN-VITRO INVESTIGATION OF DONKEY MILK EFFICACY AGAINST STANDARD
           STAPHYLOCOCCUS AUREUS STRAINS

    • Authors: Akin YIĞIN; Mehmet DEMİRCİ, Serap KILIÇ ALTUN, Bekir KOCAZEYBEK
      Abstract: has been used for therapeutic purposes since ancient times. Different studies report its antimicrobial activity against an important human pathogen such as S. aureus. Therefore, in our study, we aimed to examine the antimicrobial efficacy of donkey milk against standard MRSA and MSSA strains in-vitro environment. In our study, in-vitro antimicrobial efficacy of donkey milk obtained from 53 different donkeys against S. aureus ATCC 43300 (MRSA) and S. aureus ATCC 29213 (MSSA) was investigated by broth microdilution method. Donkey milk mixed with TSB medium at different serial dilution rates was studied in 96 microwell plates. When the effectiveness of different concentrations of donkey milk added to TSB medium in vitro against ATCC MRSA and MSSA strains was examined, no suppression was observed, and growth was found to be higher than the control results after 24 hours of incubation at high milk concentrations. In conclusion, according to the results of our study, no antimicrobial effect of donkey milk was observed in-vitro against standard MRSA and MSSA strains. This situation may be caused by the fact that S. aureus strains may have different virulence abilities, as well as the differences in protein structure in milk between species.
      PubDate: Thu, 30 Dec 2021 00:00:00 +030
       
  • INCUBATION SHARING OF NORTHERN BALD IBIS PARTNERS

    • Authors: Ahmet KILIÇ; Ersin UYSAL
      Abstract: The study was carried out during the free-flying period. Pairs share the incubation between the two sexes. In observations made between 2013 and 2015 (n=79 in day). Females incubated for 177.08 minutes per day on average while males incubated for 240.99 minutes per day. This incubation period is statistically different (P< 0.0001) withmales staying 23-32% longer than females. Females and males stayed in incubation together for only a short time. According to observations made(n=79), couples stay together on nests for 20.52 minutes in average. During the observations made all day long it was realized that eggs are left alone only 0.40 minutes on average.Incubation periods did not vary according to years. According to the observations made in 2013 (n=100) period for staying in the nest were not different than observations of years 2014 and 2015 statistically (P>0.05). According to 2014 (n=128) and 2015 (n=88) results no statistical difference could be observed between incubation periods (P>0.05).The excess eggs during incubation are protected by northern bald ibises which does not have any nest (altruism). From time to time synchronized behaviors can be observed in the population.
      PubDate: Thu, 30 Dec 2021 00:00:00 +030
       
  • ESTIMATION OF NEUTRONS OCCURRING IN THE LINAC ROOM AT DIFFERENT PHOTON
           ENERGIES

    • Authors: Taylan TUĞRUL
      Abstract: The high energy photons produced by the Linear accelerator (Linac) induce some nuclear reactions in the materials in the Linac room and Linac head. Neutrons formed as a result of the interaction of photons with materials are called photoneutrons. The aim of the study is to examine the neutron doses formed in the environment for 6 different photon energies. In the study, the components in the Linac head and the Linac chamber are modeled with the help of the Monte Carlo N-Particle (MCNP) program. Then, the flux and dose of photoneutrons formed at 8 different points as a result of 6 different photon energies obtained from the Linac head were measured. as can be seen from the results, as the photon energy used in the Linac increases, the resulting dose and flux of photoneutron increase. It can be understood from results that the amount of neutron dose to be received by the organs in the treatment field may be higher than the other organs. Especially in the treatments where the patient is lying in the prone position, there may be a possibility of neutrons reaching the patient spinal cord. Since photoneutrons with high radiobiological ability may pose a risk of secondary cancer for patients, the photon energy chosen for patient treatments should be chosen appropriately and the use of unnecessary high photon energy should be avoided.
      PubDate: Thu, 30 Dec 2021 00:00:00 +030
       
  • INVESTIGATION OF PLACENTAL HOFBAUER CELLS BY IMMUNOHISTCHEMSTRY METHODS IN
           COMPLICATED PREGNANCIES

    • Authors: Yusuf NERGİZ; Şebnem NERGİZ ÖZTÜRK, Fırat AŞIR, Ayşe ŞAHİN, Elif AĞAÇAYAK
      Abstract: Development of placenta without any complication is essential for normal pregnancy. Placenta is a multifunctional organ that plays a vital role in fetal development. Hofbauer cells are one of the most important groups of placental cells. These cells are placental macrophages and have a role in many placental events. The aim of this study is to investigate the placental distribution and density of Hofbauer cells and to contribute to the understanding of the causes and pathogenesis of complicated pregnancies. In this study, 60 full-term placentas were divided into 4 equal groups: control, preeclampsia, gestational diabetes and HELLP group. Placenta were dissected and the samples were fixed 10% neutral buffered formalin. Following routine paraffin wax procedure, 5 µm sections were stained with CD68 for marking Hofbauer cells. In immunohistochemical evaluation, Hofbauer cells in villous stroma showed positive CD68 expression. Immunostaining Findings: CD68 showed a granular staining pattern in the cytoplasm of Hofbauer cells. The group with the highest CD68 positive cell number was HELLP group and the number of cells per cell (1.46 ± 0.25) was significantly different from all groups. CD68 positive cell count in the placental villus were the highest in HELLP group and the number of Hofbauer cells per villus was significantly different from the other groups.
      PubDate: Thu, 30 Dec 2021 00:00:00 +030
       
  • BIOSENSOR PROPERTIES OF PLASMONIC SILVER NANOPARTICLES PRODUCED BY PLD

    • Authors: İlhan CANDAN; Serap YİĞİT GEZGİN, Yasemin GÜNDOĞDU, Hadice BUDAK GÜMGÜM
      Abstract: Plasmonic metal nanoparticles (NPs), such as Ag, Au, Cu NPs, attracts a lot of interest due to their notable applications in biological, and chemical sensing. Researchers have studied on plasmonic metal NPs which have exceptional optical properties in a large spectral region. Metal NPs form a unique surface plasmon resonance (SPR) peak that is in the electromagnetic spectrum’s visible part. The peak of SPR firmly depends on the NP’s size, shape, dielectric constant, and medium that the particle is in. Light interacts with nanoparticles that are smaller than the wavelength of incident light in localized surface resonance. That leads Localised Surface Plasmon Resonance (LSPR) in which an oscillating local plasma around NP with a certain frequency form. LSPR detection is the most common method for wavelength shift measurement. Analyte absorption causes a change in the local dielectric constant and thus LSPR peak shifts. Biological molecules such as proteins and antibodies can sensitively be detected as they change the local dielectric environment. Therefore, Ag or Au metal NPs can be used as sensor by employing LSPR wavelength shift technique. Among the metal NPs, Ag has a relatively higher refractive index sensitivity. Since Ag NPs have a shaper LSPR peak, they generate more precise measurements. In our work, we have produced plasmonic Ag NPs with various sizes and spherical shapes by employing Pulsed Laser Deposition (PLD). We investigated the LSPR peaks of produced plasmonic Ag NPs by UV-Vis spectroscopy. Moreover, biosensor properties of plasmonic Ag NPs are investigated by binding Protein A molecules to surface of the NPs. That produced a LSPR wavelength shift of around 100 nm/RIU.
      PubDate: Thu, 30 Dec 2021 00:00:00 +030
       
  • INVESTIGATION OF Pd@g-C3N4/TiO2 NANOPARTICLES AS PHOTOCATALYST IN THE
           DEGRADATION OF METHYLENE BLUE UNDER VISIBLE LIGHT IRRADIATION

    • Authors: Halil İbrahim ÖNAL; Feyyaz DURAP
      Abstract: In the present study, the efficiency of Pd@g-C3N4/TiO2 NPs as photocatalyst on degradation of organic pollutant methylene blue (MB) dye under visible light has been investigated. A traditional one-step impregnation-reduction method was used for the preparation of photocatalysts. Pd@g-C3N4/TiO2 NPs were characterized by several techniques such as FT-IR, DR/UV-Vis, SEM-EDX, TEM, P-XRD, and XPS analyses. The photocatalytic performance of Pd@g-C3N4/TiO2 NPs was evaluated for the degradation of MB dye under visible light irradiation. Among different loadings of Pd(0.3, 0.5, and 0.7 %), the 0.5% loading Pd@ g-C3N4/TiO2 NPs showed the highest catalytic activity. The results revealed an enhancement in the visible light photocatalytic activity of g-C3N4/TiO2 when it was coupled with Pd in the composite. Compared with pure g-C3N4/TiO2, the Pd@ g-C3N4/TiO2 hybrid photocatalyst exhibited enhanced visible light photoactivity, which was approximately three times higher than that of pure g-C3N4/TiO2.
      PubDate: Thu, 30 Dec 2021 00:00:00 +030
       
  • THREE MSA TOOLS ANALYSIS in DNA and PROTEIN DATASETS

    • Authors: Fırat AŞIR; Tuğcan KORAK, Özgür ÖZTÜRK
      Abstract: Multiple sequence alignment (MSA) is used to align three or more sequences of DNA, RNA and protein. It is prominent for constructing phylogenetic trees and evolutionary relationships between sequences with regard to similarities and dissimilarities. Variety of multiple sequence alignment tools are available online, each having different methods and parameters to align sequences. In this article three MSA tools; CLUSTALW, SAGA and MAFFT are used for five datasets BALiBASE_R9, DIRMBASE, SABmark and additionally constructed DNABali and ProteinBali for alignment. Result show that for both protein and DNA dataset, MAFFT may be more useful among three of MSA tool used.
      PubDate: Thu, 30 Dec 2021 00:00:00 +030
       
 
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