Abstract: Gastric ulcer is a common health issue. Cotinus coggygria heartwood extracts rich in the flavonoids fustin and sulfuretin have shown protective effects in a rat model of indomethacin-induced gastric ulceration. Fustin itself has been protective in a rat model of ethanol-induced gastric ulcer. In the present study we aimed to reveal the effect of the flavonoid fustin isolated from Cotinus coggygria heartwood in a rat model of indomethacin-induced gastric ulceration.Fustin was isolated from Cotinus coggygria heartwood and purified. The experiment was performed on 30 male Wistar rats allocated to three groups – Control, Indo and F10. F10 group was pretreated with fustin (10 mg/kg b.w. for 7 days). Rats were sacrificed and macroscopic, histopathological and immunohistochemical investigations of the stomachs were performed.Indomethacin caused severe mucosal damage, proven by the macroscopic, microscopic and immunohistochemical gastric mucosa investigation. Fustin pretreatment slightly reduced the macroscopic indices for gastric damage (ulcer number, area, score and index), and significantly alleviated the severity of the microscopic indices (mucosal erosions, necrosis, hemorrhages and inflammation). In fustin-pretreated rats, the expression of NF-κB was reduced in comparison with indomethacin-treated animals.In conclusion, fustin exerted a gastroprotective action in an indomethacin-induced gastric ulceration model, probably due to its anti-inflammatory activity. PubDate: Sat, 22 Jul 2023 00:00:00 GMT
Abstract: Education is defined as a major tool for raising awareness of the principles and functions of sustainable development. The problem of sustainable development, environmental and health education is subject to standards defining both content parameters in subject areas, overlapping integral fields, and options for implementation in pedagogical practice. The article presents an analysis of the problem of climate and energy efficiency, which is present only implicitly within the State educational standard for general education and curricula within the framework of the key competence common to all subjects - skills to support sustainable development and healthy lifestyle and sport. PubDate: Sat, 22 Jul 2023 00:00:00 GMT
Abstract: This comprehensive ethnobotanical study was conducted along the North Black Sea coast area to find of the extent to which indigenous knowledge of medicinal plants and their relation to Bulgarian traditions and customs is preserved. We aim to identify the tendencies of passing this knowledge to future generations.The survey was conducted in 2015 in various urban and rural North Black Sea coast areas, using a face-to-face interviews technique. We used the Chi-square test to analyse the results. Pearson correlation coefficient was used for the assessment of the impact of demographics on respondents' answers.More than half of the respondents (61.08%) are not familiar with rituals and traditional practices related to medicinal plants. Moderate influence on respondents' answers is rendered by age only. For the local population of the North Black Sea coast, Enyovden turns out to be the most popular holiday related to medicinal plants. Enyovden is the herbalists' feast and is cited by 20% of respondents. The same percentage of interviewees mention Geranium spp. and Ocimum basilicum L. as the most favoured herbs related to local traditions and customs.Traditional knowledge of the relation between Bulgarian rituals and customs to medicinal plants and their magical powers is fading. PubDate: Sat, 22 Jul 2023 00:00:00 GMT
Abstract: The traditional educational paradigm is increasingly giving way to active learning and the various possibilities for its application, which methodological basis is constructivism. They are all part of integrative learning, expressed in the creation of sustainable interdisciplinary connections. Constructivism is associated with key competencies for lifelong learning, necessary for ensuring a sustainable and adaptable to changes educational environment. This in turn requires a change in the teaching model and the application of technologies and approaches adjusted to these changes in the learning process. Part of these methods, that are successfully applied in problem-based, ecological education is project-based, and cooperative learning. PubDate: Sat, 22 Jul 2023 00:00:00 GMT
Abstract: The hectic pace of life and growing threat of cardiovascular, metabolic and neoplastic diseases highlight the demand for products with natural origin that could simultaneously be part of the balanced diet and improve human’s health. A promising finding in this respect is the Japanese quince – Chaenomeles japonica. It is an ancient plant with eastern origin, but the scientific knowledge about it has only recently started to build up.The aim of this review is to gather scientific data about chemical composition and biologic activities of Chaenomeles japonica and to provide an insight into the possible prophylactic and therapeutic applications of the plant. The gathered and summarized information concerning Japanese quince shows that preparations of different parts of the plant, especially fruits and leaves, possess biologic properties that could be of exceptional nutritional and medicinal value. Antiinflammatory, antiproliferative, antimicrobial, carbohydrate metabolism-modulating activities in in vitro studies as well as safety profile, influence on neuropsychology and behavior in animal models are discussed.This review outlines the prophylactic and therapeutic effects of Chaenomeles japonica, as well as the chemical composition that stands behind them, and aims to serve as a basis for further investigations of the medicinal plant’s potential. PubDate: Sat, 22 Jul 2023 00:00:00 GMT
Abstract: Throughout a long historical period, the natural resources of the world have been managed by different human communities. Living within the boundaries of their own ecosystems forces people to develop a deep knowledge of managing their natural resources. Whether they and their children will survive directly depends on their behavior. People have given the land and natural resources a social and symbolic value that goes beyond their immediate use value. This symbolism is based on ecological principles and supports a system of ethical, social and economic rules that are adaptive. This means that these principles and rules help human communities prevent the overexploitation of natural resources, preserve their connections with the surrounding ecosystems, so that people can live within the limits imposed by the availability of resources and technology.Over the course of the last few generations, however, the world's diversity of cultures, along with their adaptations to local environmental conditions, has been rapidly disintegrating under the influence of a new, global culture characterized by extremely high levels of consumption. Economic growth based on fossil fuel energy led to the rapid development of industry and international trade, and improved lifestyles as well as advances in health care led to rapid growth in human population and consumption. As a consequence, the search for new ways of extracting resources, involving powerful machines and efficient technologies, which absorb the traditions of conservation of nature built by local human communities during their long historical experience of survival, is intensified.Mechanisms developed as adaptations to the environment over hundreds of years are rapidly breaking down as a result of globalization, thereby freeing humans from their traditional environmental constraints. PubDate: Sat, 22 Jul 2023 00:00:00 GMT
Abstract: This work aims to analyze the quality of groundwater in the riparian areas of the bauxitic plateaus of N'Dangara and Boundou Wandé in operation by the CBG (Compagnie des Bauxites de Guinée). The geology of the study area consists mainly of sedimentary formations of the Devonian faro, Neogene and Quaternary. Three water measurement and sampling campaigns on the two plateaus were carried out with determination of piezometric measurements and physic-chemical parameters. This study showed that the general flow direction of groundwater is dispersed. The flows at Boundou Wandé are from the center of the plateau to the north and that at N'Dangara is from the center to the south and southwest. It can be seen that the direction of groundwater flow reflects overall the relief of the deposit conditioned by its geomorphological framework. It emerges from the analysis of physical and chemical parameters that well water is consumable. However, the water from wells MW15, MW16, MW17, MW18 and MW21 with a low pH (4.84 to 5.13) may present a certain nuisance for its consumption and because it can be corrosive. Analysis of the Piper diagram showed two hydrogeochemical facies (calcium and magnesium bicarbonate facies and sodium and potassium carbonate facies). However, this study strongly suggests continuous monitoring of groundwater in and around the study area in order to meet the demand for water supply to communities without compromising the ability of future generations to meet water quality requirements. PubDate: Sat, 22 Jul 2023 00:00:00 GMT
Abstract: Traditional knowledge is of real danger to be lost in modern society. This research is a part of an ethnobotanical survey aimed on documentation of current status of folk medicine in Central and Northeastern Bulgaria. Semi-structured interviews with local knowledgeable persons were provided. Quantitative ethnobotanical indices consisting of Fidelity level (FL) and Informant consensus factor (ICF) were calculated as indicatives of local importance of species and prevalent uses of species. The respondents reported 15 category uses: to treat 12 health disorders, for prophylaxis/immune stimulation, other health connected conditions and plants included in the diet as food/spices. The highest number of plants was used for the treatment of gastrointestinal diseases (65.9%), cardiovascular problems (53.4%) and urinary system problems (46.6%). It should be noted that many herbal medicines are related to disease prevention (52.3%). Maximum FL value (100%) of Hypericum perforatum for digestive and nervous system disorders and Thymus sp. for respiratory system diseases was calculated. Numerous species and specific applications were listed in the paper, contributing to the base ethnobotanical data. Specific use categories indicate most spread health disorders and proved treatments in the studied regions. Results also reflect the growing interest in disease prevention (immune stimulation) and a healthy diet. PubDate: Tue, 01 Nov 2022 00:00:00 GMT
Abstract: The most commonly used method to control wheat powdery mildew is by fungicides. The aim of the present study is to determine the duration of the fungicide activity of three fungicides: azoxystrobin; triadimenol; tebuconazole+spiroxamine+triadimenol. They were applied in three concentrations in phenophase 3-4 leaf of susceptible wheat variety. After treatment, each day one pot of the tested fungicide concentrations was inoculated with Blumeria graminis f. sp. tritici. When using azoxystrobin at concentrations of 0.2%, 0.4%, 0.8%, symptoms of powdery mildew appeared on plants inoculated with Blumeria graminis f.sp. tritici in the next day after treatment. When using triadimenol, first symptoms appeared in plants inoculated with the pathogen on the next day after applying a concentration 0.12%, on the second day after applying a concentration 0.25% and on the third day after treatment with a concentration 0.5%. With tebuconazole+spiroxamine+triadimenol, first postules appeared on plants inoculated with Blumeria graminis f. sp. tritici on the third day after treatment with a concentration 0.15%, on the 13th day after treatment with a concentration 0.3% and on the 14th day after treatment with a concentration 0.6%. This fungicide at a concentration of 0.6% (13 days) and 0.3% (12 days) has the longest duration of fungicide activity. PubDate: Tue, 01 Nov 2022 00:00:00 GMT
Abstract: Nowadays, an increased interest towards the integration of the concept of ecosystem services has been observed, both in regards to processes related to forest and water resources management, as well as in the context of sustainable development of the economy on a local, regional and national level. In the most common case, what is referred to as forest ecosystem services are possible benefits, which man can reap directly or indirectly from ecosystem functions of forest territories. Therefore, it is of great importance to analyse and assess the interactions between the human factor with the conditions and processes through which forest ecosystems create and sustain ecosystem services. The water ecosystem service provided by forest territory could cause the need to process large amounts of spatial data in the form of forest management and hydrological information, as well as information about sanitary protection zones around water sources, in the context of the administrative territorial division of the country at different levels, creates considerable challenges. The difficulties are due to both the various electronic formats in which the necessary information is maintained, and the need to perform different operations on the input data for the purpose of analysis and decision making. The present paper investigates the possibilities of automating the processing of large volumes of spatial data in the context of the ecosystem water service, provided by forest territories by developing a set of tools operating into the environment of open source GIS. The main purpose is to develop a unified approach based on the use of GIS and suitable for the creation and implementation of methods for analysis and management of processes related to the ecosystem water service provided by forest territories. The approach can be applied in different sectors of the economy, public relations and the environment. PubDate: Tue, 01 Nov 2022 00:00:00 GMT
Abstract: This study is based on observations of MWC560 during the last two observational seasons (2020/2021 and 2021/2022). Other than looking for flickering we were interested in following the variability of brightness in the same period. Looking for similarities in the spectra with other types of stars is also of great interest to us because it could help clarify the stellar configuration of such objects. Our observations during the last two observational seasons of MWC560 confirm the absence of flickering. From the similarities of the gathered spectra of XX Oph and MWC560 we assume that the components in XX Oph are a red giant and a white dwarf, which are also surrounded by a common shell. PubDate: Tue, 01 Nov 2022 00:00:00 GMT
Abstract: At present, the inventory lists of the Myriapoda of many geographical areas in Bulgaria and the comparative analyzes of the similarity between such local faunas are scarce or completely missing. The present paper presents the results of the comparative analysis of α- and β-diversity of the myriapoda communities in natural habitats in two regions in Northeastern Bulgaria – the Shumen Plateau and the Madara Plateau. The compared habitats in these plateaus have similar geographical, soil and climatic conditions, and similar species composition of plant formations. The analysis of the structure of the myriapoda communities included estimation of species diversity by determining the Shannon-Wiever index (H’) and the Berger-Parker index (d). The degree of similarity between the species composition of the communities was analyzed by the Czekanowski-Dice-Sörensen, Jaccard, Bray-Curtis, Horn, Morisita-Horn indices and the corrected Chao-Sörensen and Chao-Jaccard indices. The species diversity of the millipede community in the Shumen Plateau is much greater than that of the Madara Plateau, while the diversity of the centipede communities in the two plateaus does not differ significantly. In both classes the greatest species diversity is registered in deciduous and mixed deciduous-coniferous forests. Chao-Sörensen and Chao-Jaccard indices of similarity for the myriapod communities in these habitats are the highest, approaching 1, in contrast to the other sites where the registered species composition of the centipedes is smaller and the degree of similarity is about 0.6. PubDate: Tue, 01 Nov 2022 00:00:00 GMT
Abstract: Interactions between pentacyclic triterpenes isolated from white birch (Betula pendula Roth.) bark samples from Northeast Bulgaria and bovine serum albumin or human serum albumin were investigated using fluorescence techniques. The experimental results show the formation of complexes between the isolated triterpenes with serum albumins. Quenching of the intrinsic fluorescence of human serum albumins was monitored by emission spectra of varied quencher concentration solutions. By analysing the fluorescence spectra and fluorescence intensity, some parameters of the serum albumins - quencher interaction were determined to evaluate the type of quenching. An extract containing the isolated triterpenes formed complexes with both bovine serum albumin and human serum albumin, leading to quenching the fluorescence of both albumins by a combined quenching mechanism. PubDate: Tue, 01 Nov 2022 00:00:00 GMT
Abstract: An exopolysaccharide (EPS) was isolated from Lactobacillus plantarum Ts and purified by size exclusion chromatography train. L. plantarum showed the highest production (9.4 ± 0.8 g/l) of EPS. Furthermore, L. plantarum was cultured in medium with volume of 5 L and the EPS was extracted by ethanol precipitation. By HPLS analysis demonstrated, that the EPS has two fractions - polymer and olygomer. The molecular mass of the EPS from both fractions is respectively 8.3x104 Da for the greater pic and 5.0x102 Da. Fourier transform infrared spectroscopy analysis showed the presence of hydroxyl and carboxyl groups and glycosidic linkages. TLC analysis indicated that the EPS was a heteropolymer composed of fructose, and sucrose as monomeric constituent units. The strain L. plantarum and pathogenic E. coli 3398, St. aureus 745, B. subtilis 6633, S. typhimurium 3591, L. monocytogenes 863 and E. aerogenes 3691 were tested for their growth utilizing the EPS from L. plantarum as the sole carbon source for its possible use as a prebiotic. L. plantarum exhibited growth in the EPS supplied medium compared with sucrose as carbon source, whereas the pathogenic strains did not grow in the EPS-supplied medium. In vitro evaluations showed that, like other reported polysaccharides, this EPS displayed significant prebiotics properties. PubDate: Tue, 01 Nov 2022 00:00:00 GMT
Abstract: The morphostructural features of the Lilyak Plateau and it’s spatial and morphotectonic relationships with the adjacent parts of the Eastern Pre-Balkan Mountains are examined in the light of modern mobilist ideas. The Lilyak Plateau landform is part of the South Moesian morphostructural zone. This morphostructure borders distinctly to the south with the northern border of the corresponding part of the Fore Hemus morphostructural zone. There are significant morphostructural and morphotectonic differences between these two regional morphostructural units. PubDate: Thu, 28 Jul 2022 00:00:00 GMT
Abstract: The present development uses the modeling method described in the literature and proposed a new didactic, functional model of the “chemistry training” system in the application of semiotic approaches: semantic, pragmatic, and syntactic. The main objective of creating such a model is to demonstrate the specific activities of the subjects “teacher” and “pupil” when familiarizing themselves with chemical symbols and their study by students. The added new components in the model “Technology of chemistry training”, “Semiotic information” and the clarified links between them, lead to a complete change in the way the described system works. The developed didactic model makes it easy to guess the relationship between a new learning situation and a result, that is, to predict an unknown process or phenomenon. This model makes it possible to formulate a reasoned hypothesis of the study. PubDate: Thu, 28 Jul 2022 00:00:00 GMT
Abstract: In the present study, we report on new localities in Northeastern Bulgaria, where Elaphe sauromates (Pallas, 1814) was recently detected. We registered five Blotched snakes in the region of Shumen town in the period 2018 - 2022. All of the snakes were adults, three were killed by tools impacts and two of them were road kills. To date, the Blotched snake was registered extremely rare and in rather long intervals (of several decades) in the region of Shumen. Our findings indicate that the species currently inhabits the suburban and urban territories near the villages of Ivanski, Radko Dimitrievo and Konyovets. Two of the locations are new for the 10 km grid-system used for standard monitoring of the biodiversity in Bulgaria. PubDate: Thu, 28 Jul 2022 00:00:00 GMT
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