Subjects -> MEDICAL SCIENCES (Total: 8810 journals)
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INTERNAL MEDICINE (180 journals)                     

Showing 1 - 180 of 180 Journals sorted alphabetically
Abdomen     Open Access  
ACP Hospitalist     Full-text available via subscription   (Followers: 9)
ACP Internist     Full-text available via subscription   (Followers: 10)
ACP Journal Club     Full-text available via subscription   (Followers: 11)
Acta Clinica Belgica     Hybrid Journal   (Followers: 1)
Acute and Critical Care     Open Access   (Followers: 11)
Acute Medicine     Full-text available via subscription   (Followers: 9)
Advances in Hepatology     Open Access   (Followers: 4)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6)
African Journal of Primary Health Care & Family Medicine     Open Access   (Followers: 6)
African Journal of Thoracic and Critical Care Medicine     Open Access  
American Family Physician     Full-text available via subscription   (Followers: 38)
American Journal of Hypertension     Hybrid Journal   (Followers: 31)
Anales de Medicina Interna     Open Access   (Followers: 1)
Anatomy & Physiology : Current Research     Open Access   (Followers: 9)
Angiology     Hybrid Journal   (Followers: 5)
Annals of Colorectal Research     Open Access   (Followers: 1)
Annals of Internal Medicine     Full-text available via subscription   (Followers: 392)
AORN Journal     Hybrid Journal   (Followers: 27)
Apollo Medicine     Open Access  
Archives of Drug Information     Hybrid Journal   (Followers: 5)
Archivos de Medicina Interna     Open Access   (Followers: 1)
Asia Oceania Journal of Nuclear Medicine & Biology     Open Access   (Followers: 4)
Asian Pacific Journal of Tropical Disease     Full-text available via subscription   (Followers: 3)
Australasian Physical & Engineering Sciences in Medicine     Hybrid Journal   (Followers: 1)
BMI Journal : Bariátrica & Metabólica Iberoamericana     Open Access   (Followers: 1)
BMJ Open Diabetes Research & Care     Open Access   (Followers: 35)
BMJ Quality & Safety     Hybrid Journal   (Followers: 69)
Bone & Joint Journal     Hybrid Journal   (Followers: 138)
Brain Communications     Open Access   (Followers: 4)
Brain Science Advances     Open Access  
Canadian Journal of General Internal Medicine     Open Access   (Followers: 2)
Cardiovascular Medicine in General Practice     Full-text available via subscription   (Followers: 7)
Case Reports in Internal Medicine     Open Access   (Followers: 1)
Cell Death & Disease     Open Access   (Followers: 3)
Cellular and Molecular Gastroenterology and Hepatology     Open Access   (Followers: 3)
Cephalalgia     Hybrid Journal   (Followers: 8)
Cephalalgia Reports     Open Access   (Followers: 4)
Chronic Diseases and Injuries in Canada     Free   (Followers: 1)
Clinical Ethics     Hybrid Journal   (Followers: 13)
Clinical Liver Disease     Open Access   (Followers: 5)
Clinical Nutrition     Hybrid Journal   (Followers: 98)
Clinical Thyroidology     Full-text available via subscription   (Followers: 1)
CNE Pflegemanagement     Hybrid Journal  
Communication Law and Policy     Hybrid Journal   (Followers: 5)
Current Diabetes Reports     Hybrid Journal   (Followers: 30)
Current Hepatology Reports     Hybrid Journal  
Current Research: Integrative Medicine     Open Access  
CVIR Endovascular     Open Access   (Followers: 1)
Der Internist     Hybrid Journal   (Followers: 12)
Diabetes     Full-text available via subscription   (Followers: 603)
Diabetes Care     Full-text available via subscription   (Followers: 578)
Diabetes Internacional     Open Access  
Diabetes Spectrum     Full-text available via subscription   (Followers: 17)
Diagnosis     Hybrid Journal   (Followers: 1)
Egyptian Journal of Bronchology     Open Access  
Egyptian Journal of Internal Medicine     Open Access   (Followers: 1)
Egyptian Journal of Neurosurgery     Open Access  
Egyptian Liver Journal     Open Access   (Followers: 2)
Egyptian Spine Journal     Open Access  
EMC - Aparato Locomotor     Hybrid Journal  
Endovascular Neuroradiology / Ендоваскулярна нейрорентгенохірургія     Open Access   (Followers: 1)
eNeuro     Open Access   (Followers: 3)
Ergonomics     Hybrid Journal   (Followers: 24)
European Journal of Inflammation     Open Access   (Followers: 2)
European Journal of Internal Medicine     Full-text available via subscription   (Followers: 10)
European Journal of Translational Myology     Open Access  
European Radiology Experimental     Open Access   (Followers: 2)
Head and Neck Tumors     Open Access   (Followers: 1)
Health Sociology Review     Hybrid Journal   (Followers: 14)
HemaSphere     Open Access   (Followers: 2)
Hepatology Communications     Open Access  
Hepatoma Research     Open Access   (Followers: 3)
Human Physiology     Hybrid Journal   (Followers: 5)
ImmunoHorizons     Open Access  
Immunological Medicine     Open Access  
Infectious Diseases: Research and Treatment     Open Access   (Followers: 5)
Inflammation and Regeneration     Open Access   (Followers: 2)
Inflammatory Intestinal Diseases     Open Access  
Innere Medizin up2date     Hybrid Journal   (Followers: 1)
Internal and Emergency Medicine     Hybrid Journal   (Followers: 5)
Internal Medicine Journal     Hybrid Journal   (Followers: 9)
International Journal of Abdominal Wall and Hernia Surgery     Open Access   (Followers: 1)
International Journal of Anatomy and Research     Open Access   (Followers: 2)
International Journal of Angiology     Hybrid Journal  
International Journal of Artificial Organs     Hybrid Journal   (Followers: 3)
International Journal of Hyperthermia     Open Access  
International Journal of Internal Medicine     Open Access   (Followers: 3)
International Journal of Noncommunicable Diseases     Open Access  
International Journal of Psychiatry in Clinical Practice     Hybrid Journal   (Followers: 6)
Iranian Journal of Neurosurgery     Open Access   (Followers: 1)
Italian Journal of Anatomy and Embryology     Open Access   (Followers: 1)
JAC-Antimicrobial Resistance     Open Access   (Followers: 4)
JAMA Internal Medicine     Full-text available via subscription   (Followers: 364)
JCSM Clinical Reports     Open Access   (Followers: 3)
JHEP Reports     Open Access  
JIMD Reports     Open Access  
JMV - Journal de Médecine Vasculaire     Hybrid Journal   (Followers: 1)
Joint Commission Journal on Quality and Patient Safety     Hybrid Journal   (Followers: 41)
JOP. Journal of the Pancreas     Open Access   (Followers: 2)
Journal of Basic & Clinical Physiology & Pharmacology     Hybrid Journal   (Followers: 1)
Journal of Bone Oncology     Open Access   (Followers: 1)
Journal of Cancer & Allied Specialties     Open Access  
Journal of Clinical and Experimental Hepatology     Full-text available via subscription   (Followers: 3)
Journal of Clinical Movement Disorders     Open Access   (Followers: 3)
Journal of Community Hospital Internal Medicine Perspectives     Open Access  
Journal of Cutaneous Immunology and Allergy     Open Access  
Journal of Developmental Origins of Health and Disease     Hybrid Journal   (Followers: 2)
Journal of Endoluminal Endourology     Open Access  
Journal of Gastroenterology and Hepatology Research     Open Access   (Followers: 4)
Journal of General Internal Medicine     Hybrid Journal   (Followers: 23)
Journal of Hypertension     Hybrid Journal   (Followers: 14)
Journal of Infectious Diseases     Hybrid Journal   (Followers: 48)
Journal of Interdisciplinary Medicine     Open Access  
Journal of Internal Medicine     Hybrid Journal   (Followers: 11)
Journal of Liver : Disease & Transplantation     Hybrid Journal   (Followers: 7)
Journal of Medical Internet Research     Open Access   (Followers: 24)
Journal of Movement Disorders     Open Access   (Followers: 2)
Journal of Pain and Symptom Management     Hybrid Journal   (Followers: 46)
Journal of Pancreatic Cancer     Open Access  
Journal of Renal and Hepatic Disorders     Open Access  
Journal of Solid Tumors     Open Access   (Followers: 1)
Journal of Sports Medicine and Allied Health Sciences : Official Journal of the Ohio Athletic Trainers Association     Open Access   (Followers: 1)
Journal of the American Board of Family Medicine     Open Access   (Followers: 11)
Journal of the European Mosquito Control Association     Open Access  
Journal of Translational Internal Medicine     Open Access  
Jurnal Vektor Penyakit     Open Access  
La Revue de Medecine Interne     Full-text available via subscription   (Followers: 3)
Lege artis - Das Magazin zur ärztlichen Weiterbildung     Hybrid Journal   (Followers: 1)
Liver Cancer International     Open Access  
Liver Research     Open Access  
Molecular Diagnosis & Therapy     Hybrid Journal   (Followers: 3)
Molecular Therapy - Oncolytics     Open Access  
Multiple Sclerosis and Demyelinating Disorders     Open Access   (Followers: 7)
MYOPAIN. A journal of myofascial pain and fibromyalgia     Hybrid Journal   (Followers: 18)
Neuro-Oncology Advances     Open Access   (Followers: 1)
Neurobiology of Pain     Open Access   (Followers: 2)
Neurointervention     Open Access   (Followers: 6)
Neuromuscular Diseases     Open Access  
Nigerian Journal of Gastroenterology and Hepatology     Full-text available via subscription  
OA Alcohol     Open Access   (Followers: 5)
Oncological Coloproctology     Open Access  
Open Journal of Internal Medicine     Open Access  
Pleura and Peritoneum     Open Access  
Pneumo News     Full-text available via subscription  
Polish Archives of Internal Medicine     Full-text available via subscription   (Followers: 2)
Preventing Chronic Disease     Free   (Followers: 2)
Progress in Transplantation     Hybrid Journal   (Followers: 1)
Prostate International     Open Access   (Followers: 2)
Psychiatry and Clinical Psychopharmacology     Open Access   (Followers: 1)
Pulmonary Therapy     Open Access   (Followers: 2)
Quality of Life Research     Hybrid Journal   (Followers: 20)
Research and Practice in Thrombosis and Haemostasis     Open Access  
Revista Chilena de Fonoaudiología     Open Access   (Followers: 1)
Revista de la Sociedad Peruana de Medicina Interna     Open Access   (Followers: 4)
Revista del Instituto de Medicina Tropical     Open Access  
Revista Hispanoamericana de Hernia     Open Access   (Followers: 1)
Revista Médica Internacional sobre el Síndrome de Down     Full-text available via subscription   (Followers: 1)
Revista Virtual de la Sociedad Paraguaya de Medicina Interna     Open Access   (Followers: 1)
Romanian Journal of Diabetes Nutrition and Metabolic Diseases     Open Access   (Followers: 1)
Romanian Journal of Internal Medicine     Open Access  
Russian Journal of Child Neurology     Open Access   (Followers: 1)
Scandinavian Journal of Primary Health Care     Open Access   (Followers: 8)
Schlaf     Hybrid Journal  
Schmerzmedizin     Hybrid Journal  
Scientific Journal of the Foot & Ankle     Open Access   (Followers: 1)
SciMedicine Journal     Open Access   (Followers: 3)
SEMERGEN - Medicina de Familia     Full-text available via subscription   (Followers: 1)
The Journal of Critical Care Medicine     Open Access   (Followers: 9)
Therapeutic Advances in Chronic Disease     Open Access   (Followers: 8)
Therapeutic Advances in Musculoskeletal Disease     Hybrid Journal   (Followers: 6)
Thieme Case Report     Hybrid Journal   (Followers: 1)
Tijdschrift voor Urologie     Hybrid Journal  
Tissue Barriers     Hybrid Journal   (Followers: 1)
Transactions of the Royal Society of Tropical Medicine and Hygiene     Hybrid Journal   (Followers: 3)
Transgender Health     Open Access   (Followers: 3)
Trends in Anaesthesia and Critical Care     Full-text available via subscription   (Followers: 23)
US Cardiology Review     Open Access  
Vascular and Endovascular Review     Open Access   (Followers: 1)
Ожирение и метаболизм     Open Access  


Similar Journals
Journal Cover
Journal of Hypertension
Journal Prestige (SJR): 1.733
Citation Impact (citeScore): 3
Number of Followers: 14  
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0263-6352 - ISSN (Online) 1473-5598
Published by LWW Wolters Kluwer Homepage  [301 journals]
  • Highlights of the June issue
    • Authors: Mancia; Giuseppe
      Abstract: No abstract available
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Association between arterial stiffness and the clustering of metabolic
           syndrome risk factors: a systematic review and meta-analysis
    • Authors: Sequí-Domínguez; Irene; Cavero-Redondo, Iván; Álvarez-Bueno, Celia; Saz-Lara, Alicia; Mesas, Arthur E.; Martínez-Vizcaíno, Vicente
      Abstract: imageObjectives: Metabolic syndrome (MetS) is a cluster of different cardiometabolic risk factors (CMRFs), and its different combinations with other CMRFs, such as arterial stiffness have been hypothesized to explain, at least partially, increased risk of cardiovascular disease. Thus, in this systematic review and meta-analysis, we aimed to synthesize the evidence regarding the association between the clustering of MetS-related CMRFs and arterial stiffness measured using pulse wave velocity (PWV).Methods: Original studies analysing the association between arterial stiffness, measured using PWV, and MetS were systematically searched. Pooled effect size estimates and their respective 95% confidence intervals (CI) were calculated using the DerSimonian and Laird method for two separate analyses: the diagnosis of MetS and PWV values and the number of CMRFs and PWV values.Results: Moderate effect size estimates were observed between MetS and PWV (0.68, 95% CI: 0.54–0.82) with a slightly higher effect size for the low-risk compared with the high-risk population group (0.75, 95% CI: 0.58–0.92; and 0.51, 95% CI: 0.32–0.82, respectively). A trend between the number of MetS-related CMRFs and PWV was found with the pooled effect size nearly doubling as the number of MetS-related CMRFs increased, 0.11 (95% CI: 0.04–0.17) for one MetS-related CMRF, 0.26 (95% CI: 0.13–0.4) for two, and 0.4 (95% CI: 0.2–0.6) for three or more.Conclusion: These results demonstrated a clinically relevant association between MetS and PWV and an increasing trend in PWV values, such as a MetS-related CMRF increase. Although these results should be considered cautiously because of the considerable heterogeneity, our findings reinforce the rationale of MetS as an aggregation of risk factors with common causes, which could provide additional useful information to guide clinical management.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Elevated heart rate and cardiovascular risk in hypertension
    • Authors: Mancia; Giuseppe; Masi, Stefano; Palatini, Paolo; Tsioufis, Costas; Grassi, Guido
      Abstract: imageEpidemiological studies have shown that chronically elevated resting heart rate (HR) is significantly associated with organ damage, morbidity and mortality in a wide range of patients including hypertensive patients. Evidence is also available that an increased HR reflects sympathetic nervous system overdrive which is also known to adversely affect organ structure and function and to increase the risk of unfavourable outcomes in several diseases. The causal relationship between elevated HR, organ damage, and cardiovascular outcomes can thus be explained by its relationship with sympathetic cardiovascular influences although evidence of sympathetically-independent adverse effect of HR increases per se makes it more complex. Interventions that target HR by modulating the sympathetic nervous system have therefore a strong pathophysiological and clinical rationale. As most clinical guidelines now recommend the use of combination therapies in patients with hypertension, it might be desirable to consider as combination components drugs which lower HR, if HR is elevated such as, according to guideliines, when it is above 80 b/min.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Scientific mapping of the research output on hypertension in children and
           adolescents, 2010–2018
    • Authors: Abad-García; María-Francisca; González-Teruel, Aurora; Bolaños-Pizarro, Máxima; Lurbe I. Ferrer, Empar
      Abstract: imageObjective: The area of pediatric hypertension (HTN) research has seen substantial progress over the last two decades, but no bibliometric analysis has yet been undertaken to describe these advances. This study aims to describe the published research examining HTN in children and adolescents from 2000 to 2018.Methods: Articles were retrieved using PubMed and the Web of Science. Analyses were performed to quantify the evolution of scientific output, identifying the leading journals, authors, and countries as well as the existing collaboration networks. Likewise, we identified the most cited articles, describing their document type, main topic focus, and the age of the patients studied.Results: In total, we identified 8317 articles in the Web of Science. The annual number of publications doubled over the study period. Articles were published in 1415 journals, mainly in the categories of Peripheral & Vascular Diseases and Pediatrics. The USA dominated scientific production in the field. Regarding researcher productivity, the top 202 authors participated in 20% of the articles, and there were 47 stable research clusters, with the largest component made up of 17 authors. Altogether, there were 145 most cited articles, with an irregular annual distribution; about half focus on HTN itself, while the rest study associated disorders and conditions.Conclusion: This is the first study to analyze scientific output on HTN in children and adolescents. The snapshot that emerges is of a research area that is growing but is still in a relatively early phase of development.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Lifestyle, psychological, socioeconomic and environmental factors and
    • Authors: Kreutz; Reinhold; Dobrowolski, Piotr; Prejbisz, Aleksander; Algharably, Engi A.E-H; Bilo, Grzegorz; Creutzig, Felix; Grassi, Guido; Kotsis, Vasilios; Lovic, Dragan; Lurbe, Empar; Modesti, Pietro A.; Pappaccogli, Marco; Parati, Gianfranco; Persu, Alexandre; Polonia, Jorge; Rajzer, Marek; de Timary, Philippe; Weber, Thomas; Weisser, Burkhard; Tsioufis, Konstantinos; Mancia, Giuseppe; Januszewicz, Andrzej; European Society of Hypertension COVID-19 Task Force Review
      Abstract: imageSummary: The coronavirus disease 2019 (COVID-19) pandemic considerably affects health, wellbeing, social, economic and other aspects of daily life. The impact of COVID-19 on blood pressure (BP) control and hypertension remains insufficiently explored. We therefore provide a comprehensive review of the potential changes in lifestyle factors and behaviours as well as environmental changes likely to influence BP control and cardiovascular risk during the pandemic. This includes the impact on physical activity, dietary patterns, alcohol consumption and the resulting consequences, for example increases in body weight. Other risk factors for increases in BP and cardiovascular risk such as smoking, emotional/psychologic stress, changes in sleep patterns and diurnal rhythms may also exhibit significant changes in addition to novel factors such as air pollution and environmental noise. We also highlight potential preventive measures to improve BP control because hypertension is the leading preventable risk factor for worldwide health during and beyond the COVID-19 pandemic.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Sodium--glucose co-transporter-2 inhibitors for patients with diabetic and
           nondiabetic chronic kidney disease: a new era has already begun
    • Authors: Sarafidis; Pantelis; Ortiz, Alberto; Ferro, Charles J.; Halimi, Jean-Michel; Kreutz, Reinhold; Mallamaci, Francesca; Mancia, Giuseppe; Wanner, Christoph; for the ‘Hypertension Cardiovascular Medicine’
      Abstract: imageChronic kidney disease (CKD) is a major issue of public health. Hypertension control and use of renin--angiotensin system (RAS) blockers are the cornerstones of treatment for CKD of any cause. However, even under optimal RAS blockade, many individuals will progress towards more advanced CKD. Within the past few years, evidence from cardiovascular outcome trials with sodium--glucose co-transporter-2 (SGLT-2) inhibitors clearly suggested that these agents substantially delay CKD progression in patients with diabetes mellitus on top of standard-of-care treatment. The Canagliflozin-and-Renal-Events-in-Diabetes-with-Established-Nephropathy-Clinical-Evaluation (CREDENCE) study, showed that canagliflozin substantially reduced the risk of doubling of SCr, end-stage kidney disease (ESKD), or death from renal or cardiovascular causes in 4401 patients with diabetic CKD compared with placebo (hazard ratio 0.70; 95% CI 0.59–0.82). Recently, the Study-to-Evaluate-the-Effect-of-Dapagliflozin-on-Renal-Outcomes-and-Cardiovascular-Mortality-in-Patients-With-Chronic-Kidney-Disease (DAPA-CKD), including 2510 patients with diabetic and 1803 with nondiabetic CKD, also showed an impressive reduction in the risk of ≥50% decline in eGFR, ESKD, or death from renal or cardiovascular causes (HR 0.61; 95% CI 0.51–0.72). The benefit was similar for patients with diabetic and nondiabetic CKD, including patients with glomerulonephritides. Following this conclusive evidence, relevant guidelines should accommodate their recommendations to implement treatment with SGLT-2 inhibitors for patients with diabetic and nondiabetic CKD.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • A new therapy for sleep apnea'
    • Authors: Zoccali; Carmine; Mallamaci, Francesca
      Abstract: imageNo abstract available
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Normotensive aging: finally, an ‘iron in the fire’
    • Authors: Nair; Tiny; Ram, C. Venkata S.
      Abstract: No abstract available
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Editorial commentary on ‘Country of birth and mortality risk in
           hypertension with and without diabetes: the Swedish Primary Care
           Cardiovascular Database’
    • Authors: Egan; Brent M.; Sutherland, Susan E.
      Abstract: imageNo abstract available
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Therapeutic inertia in hypertension management – status quo in
           primary care
    • Authors: Schlaich; Markus P.; Kiuchi, Marcio G.; Nolde, Janis M.; Lugo-Gavidia, Leslie Marisol; Carnagarin, Revathy
      Abstract: No abstract available
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Haemodynamic assessment in hypertension: the soloists and the orchestra
    • Authors: Murray; Eleanor; Rossitto, Giacomo; Delles, Christian
      Abstract: No abstract available
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Enterococcus faecalis contributes to hypertension and renal injury in
           Sprague-Dawley rats by disturbing lipid metabolism
    • Authors: Zhu; Yeyan; Liu, Yuting; Wu, Chunying; Li, Haonan; Du, Huiting; Yu, Huijing; Huang, Cailin; Chen, Yating; Wang, Weidong; Zhu, Qing; Wang, Lei
      Abstract: imageObjective: Increasing studies have demonstrated that gut microbiota play vital roles in the development of hypertension. However, the underlying mechanism is not fully understood.Methods: The relative abundance of Enterococcus faecalis was determined in the faecal samples of angiotensin II or deoxycorticosterone acetate/salt-induced hypertensive rats. Then, E. faecalis culture was administered orally to rats for 6 weeks. Blood pressure (BP) was measured, renal injury was estimated and a serum metabolomic analysis was performed.Results: Compared with control, E. faecalis was markedly enriched in the faecal samples of hypertensive rats. The rats receiving live E. faecalis but not dead bacteria exhibited higher BP and enhanced renal injury. The serum metabolomic data showed that the E. faecalis treatment resulted in 35 variable metabolites including 16 (46%) lipid/lipid-like molecules, suggesting significant disturbance of lipid metabolism. Furthermore, the mRNA levels of 18 lipid metabolic enzymes in the renal medulla and cortex presented distinct and dynamic changes in response to 3 or 6-week E. faecalis treatment. Consistently, the protein levels of lysophospholipases A1 (LYPLA1) and phospholipase A2 group 4 A (PLA2G4) were enhanced only by live E. faecalis, which thus may have decreased the nitric oxide production in the renal medulla and elevated BP.Conclusion: Our results suggest that E. faecalis in the gut contributes to hypertension and renal injury in rats by disturbing the lipid metabolism. The information provided here could shed new light on the pathologic mechanisms and potential intervention targets for the treatment of gut dysbiosis-induced hypertension.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Carbamylated form of human erythropoietin normalizes cardiorespiratory
           disorders triggered by intermittent hypoxia mimicking sleep apnea syndrome
    • Authors: Andrade; David C.; Toledo, Camilo; Diaz, Hugo S.; Pereyra, Katherin V.; Schwarz, Karla G.; Díaz-Jara, Esteban; Melipillan, Claudia; Rios-Gallardo, Angélica P.; Uribe-Ojeda, Atenea; Alcayaga, Julio; Quintanilla, Rodrigo A.; Iturriaga, Rodrigo; Richalet, Jean-Paul; Voituron, Nicolas; Del Rio, Rodrigo
      Abstract: imageBackground and objective: Chronic intermittent hypoxia (CIH), one of the main features of obstructive sleep apnea (OSA), enhances carotid body-mediated chemoreflex and induces hypertension and breathing disorders. The carbamylated form of erythropoietin (cEpo) may have beneficial effects as it retains its antioxidant/anti-inflammatory and neuroprotective profile without increasing red blood cells number. However, no studies have evaluated the potential therapeutic effect of cEpo on CIH-related cardiorespiratory disorders. We aimed to determine whether cEpo normalized the CIH-enhanced carotid body ventilatory chemoreflex, the hypertension and ventilatory disorders in rats.Methods: Male Sprague–Dawley rats (250 g) were exposed to CIH (5% O2, 12/h, 8 h/day) for 28 days. cEPO (20 μg/kg, i.p) was administrated from day 21 every other day for one more week. Cardiovascular and respiratory function were assessed in freely moving animals.Results: Twenty-one days of CIH increased carotid body-mediated chemoreflex responses as evidenced by a significant increase in the hypoxic ventilatory response (FiO2 10%) and triggered irregular eupneic breathing, active expiration, and produced hypertension. cEpo treatment significantly reduced the carotid body--chemoreflex responses, normalizes breathing patterns and the hypertension in CIH. In addition, cEpo treatment effectively normalized carotid body chemosensory responses evoked by acute hypoxic stimulation in CIH rats.Conclusion: Present results strongly support beneficial cardiorespiratory therapeutic effects of cEpo during CIH exposure.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Blood pressure control in Australian general practice: analysis using
           general practice records of 1.2 million patients from the MedicineInsight
    • Authors: Roseleur; Jacqueline; Gonzalez-Chica, David A.; Bernardo, Carla O.; Geisler, Benjamin P.; Karnon, Jonathan; Stocks, Nigel P.
      Abstract: imageIntroduction: Hypertension is mostly managed in primary care. This study investigated the prevalence of diagnosed hypertension in Australian general practice and whether hypertension control is influenced by sociodemographic characteristics, duration since diagnosis or prescription of antihypertensive medications.Methods: Cross-sectional study using a large national database of electronic medical records of patients attending general practice in 2017 (MedicineInsight).Results: Of 1.2 million ‘regular’ patients (one or more consultations per year in every year from 2015 to 2017), 39.8% had a diagnosis of hypertension (95% confidence interval 38.7–40.9). Of these, 85.3% had their blood pressure (BP) recorded in 2017, and 54.9% (95% confidence interval 54.2–55.5) had controlled hypertension (5 years = 55.0%). Among recently diagnosed ‘regular’ patients, 59.2% had no record of being prescribed antihypertensive therapy in the last 6 months of the study, of which 44.3% had controlled hypertension. For those diagnosed more than 5 years ago, 37.4% had no record of being prescribed antihypertensive patients, and 56% had normal BP levels.Conclusion: Although the prevalence of hypertension varied by socidemographics, there were no differences in BP assessment or control by socioeconomic status. Hypertension control remains a challenge in primary care, and electronic medical records provide an opportunity to assess hypertension management.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Association of age and blood pressure among 3.3 million adults: insights
           from China PEACE million persons project
    • Authors: The China PEACE Collaborative Group*
      Abstract: imageObjective: To assess the association between blood pressure (BP) with age and its heterogeneity across various sociodemographic subgroups in China.Methods: In this cross-sectional study, we analysed the data from nearly 3.3 million individuals aged 35–75 years from all 31 provinces in mainland China collected from September 2014 through August 2019. On the basis of possible combinations of eight characteristics and antihypertensive status, subgroups of at least 10 000 individuals were created and the age--blood pressure relationship was determined for each group.Results: The study included 3 291 058 participants (59.6% women), with a mean age of 55.8 ± 9.8 years. The prevalence of hypertension was 47.6%, of which 30.0% were taking antihypertensive medications. The mean SBP was 135.9 ± 20.2 mmHg. SBP increased at a mean unadjusted rate of 0.639 ± 0.001 mmHg/year. For 95% of the 25 145 subgroups, the SBP increased by 0.28--0.85 mmHg/year. The most common characteristics in the subgroups with the steepest association were female sex, rural area, low education, low-income family, Tibet region, and farmer occupation. The increase in SBP ranged from 0.13 to 0.41 mmHg/year for 95% of the treated subgroups and from 0.33 to 0.82 mmHg/year for 95% of the untreated subgroups.Conclusion: Blood pressure is positively associated with age in this study, with almost three-fold variation across subgroups, indicating subgroup differences in biology, behaviour, or exposures. Antihypertension strongly blunts the association of age and blood pressure and diminishes the variation.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Country of birth and mortality risk in hypertension with and without
           diabetes: the Swedish primary care cardiovascular database
    • Authors: Andersson; Tobias; Pikkemaat, Miriam; Schiöler, Linus; Hjerpe, Per; Carlsson, Axel C.; Wändell, Per; Manhem, Karin; Kahan, Thomas; Bengtsson Boström, Kristina
      Abstract: imageObjectives: Hypertension and diabetes are common and are both associated with high cardiovascular morbidity and mortality. We aimed to investigate associations between mortality risk and country of birth among hypertensive individuals in primary care with and without concomitant diabetes, which has not been studied previously. In addition, we aimed to study the corresponding risks of myocardial infarction and ischemic stroke.Methods: This observational cohort study of 62 557 individuals with hypertension diagnosed 2001–2008 in the Swedish Primary Care Cardiovascular Database assessed mortality by the Swedish Cause of Death Register, and myocardial infarction and ischemic stroke by the National Patient Register. Cox regression models were used to estimate study outcome hazard ratios by country of birth and time updated diabetes status, with adjustments for multiple confounders.Results: During follow-up time without diabetes using Swedish-born as reference, adjusted mortality hazard ratios per country of birth category were Finland: 1.26 (95% confidence interval 1.15–1.38), high-income European countries: 0.84 (0.74–0.95), low-income European countries: 0.84 (0.71–1.00) and non-European countries: 0.65 (0.56–0.76). The corresponding adjusted mortality hazard ratios during follow-up time with diabetes were high-income European countries: 0.78 (0.63–0.98), low-income European countries: 0.74 (0.57–0.96) and non-European countries: 0.56 (0.44–0.71). During follow-up without diabetes, the corresponding adjusted hazard ratio of myocardial infarction was increased for Finland: 1.16 (1.01–1.34), whereas the results for ischemic stroke were inconclusive.Conclusion: In Sweden, hypertensive immigrants (with the exception for Finnish-born) with and without diabetes have a mortality advantage, as compared to Swedish-born.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Prognostic role of the ascending aorta dilatation in patients with
           arterial hypertension
    • Authors: Leone; Dario; Airale, Lorenzo; Bernardi, Sara; Mingrone, Giulia; Astarita, Anna; Cesareo, Marco; Sabia, Luca; Avenatti, Eleonora; Tosello, Francesco; Bruno, Giulia; Catarinella, Cinzia; Venturelli, Veronica; Giordana, Carlo; Veglio, Franco; Vallelonga, Fabrizio; Milan, Alberto
      Abstract: imageBackground: Ascending aorta (ASC) dilatation (AAD) is a common finding in arterial hypertension, affecting about 15% of hypertensive patients. AAD is associated with an increase in cardiac and vascular hypertension-related organ damage, but its prognostic role is unknown. The aim of the study was to evaluate the prognostic value of AAD as predictor of cardiovascular events in essential hypertensive patients.Methods: Recruited patients underwent two-dimensional transthoracic echocardiography from 2007 to 2013 and followed-up for cardiovascular events until November 2018 by phone call and hospital information system check. ASC diameter and AAD were defined using both absolute and scaled definitions. Four hundred and twenty-three hypertensive patients were included in our study.Results: During a median follow-up of 7.4 years (interquartile range 5.6–9.1 years), 52 events were observed. After adjusting for age, sex and BSA, both ASC diameter and AAD definition, according to ARGO-SIIA project, resulted associated with a greater risk of cardiovascular event (both P 
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Effect of frequency and pattern of night shift on hypertension risk in
           female nurses: a cross-sectional study
    • Authors: Zhao; Bin; Li, Jing; Feng, Di; Liu, Jie; Hao, Yuming; Zhen, Yanjie; Hao, Xiaoran; Liu, Fude; Zuo, Aifang; Yang, Xiulan; Chen, Ximin; Jia, Rufu; Zhang, Ruiqin; Fan, Ailing; Wang, Yun; Yuan, Meijin; Li, Bin; Chen, Shuling; Cui, Jing; Li, Xian; Ding, Junqin; Zhao, Meizhu; Li, Laiyou; Li, Lanfeng; Yin, Xiaohua; Li, Yuzhuo; Huang, Xianghe; Yu, Hongwei; Li, Yun; Cui, Wei
      Abstract: imageObjectives: Understanding the effect of night shift on hypertension risk in nurses is important to improve the health of nurses and ensure patient safety. This study aimed to evaluate the effect of the frequency and pattern of night shift on hypertension risk and the interaction of them in female nurses.Methods: This cross-sectional study constituted 84 697 female nurses in 13 cities in China. The main contents of the survey included SBP, DBP, the frequency and pattern of night shift, and some other factors that might be associated with hypertension. Logistic regression analyses were used to calculate ORs and 95% CIs to estimate the effect of the frequency and pattern of night shift on hypertension risk and the interaction of them in relation to hypertension risk.Results: Having more than 5 to 10 or more than 10 night shifts per month were significantly more likely to be hypertensive (OR 1.19, 95% CI 1.10–1.28; OR 1.32, 95% CI 1.13–1.54), whereas having less than or equal to 5 night shifts per month was not (OR 1.05, 95% CI 0.95–1.16). The patterns of night shift were all associated with a higher probability of hypertension and participants engaging in rapidly rotating night shift had a lower OR (1.14) than those having slowly rotating night shift (1.23) and permanent night shift (1.46). No significant interaction was observed between the frequency and the pattern of night shift (Pinteraction = 0.281).Conclusion: The frequency and pattern of night shift were associated with hypertension risk in female nurses and no significant interaction was observed between them.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Associations of the nocturnal blood pressure fall and morning surge with
           cardiovascular events and mortality in individuals with resistant
    • Authors: Cardoso; Claudia R.L.; Salles, Gil F.
      Abstract: imageObjective: The prognostic importance of the nocturnal blood pressure (BP) fall and early-morning surge were scarcely investigated in patients with resistant hypertension (RHT). We investigated them in a prospective cohort of 1726 RHT individuals.Methods: The nocturnal fall and morning surge were calculated from the baseline ambulatory BP monitoring (ABPM) and also as mean cumulative values using all ABPMs performed during follow-up. Dipping patterns (normal, extreme, reduced, and reverse) were defined by classic cut-off values of the night-to-day ratio, while MS (difference between early-morning and night-time BP) was categorized into quartiles and at the extremes of its distribution (5th, 10th, 90th, and 95th percentiles). The primary outcomes were total cardiovascular events (CVEs), major adverse cardiovascular events (MACEs), all-cause and cardiovascular mortalities. Multivariate Cox analyses examined the associations between nocturnal BP fall and morning surge and outcomes.Results: Over a median follow-up of 8.3 years, 417 CVEs occurred (358 MACEs), and 391 individuals died (233 cardiovascular deaths). Reduced and reverse dipping patterns were significant predictors of CVEs and MACEs, with hazard ratios between 1.6 and 2.5, whereas extreme dipping was a protective factor in younger individuals (hazard ratios 0.3--0.4) but a hazardous factor in elderly (hazard ratios 3.7--5.0) and in individuals with previous cardiovascular diseases (hazard ratios 2.6--4.4). No morning surge parameter was predictive of any outcome in fully adjusted analyses.Conclusion: Abnormal dipping patterns but not the early-morning BP surge, were important prognostic markers for future cardiovascular morbidity in RHT patients. The prognosis of extreme dippers depended on age and the presence of cardiovascular diseases.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • The association between self-perceived walking pace with the incidence of
           hypertension: the ‘Seguimiento Universidad de Navarra’ cohort
    • Authors: Etzig; Cassandra; Gea, Alfredo; Martínez-González, Miguel Á.; Sullivan, Mark F. Jr; Sullivan, Elixabeth; Bes-Rastrollo, Maira
      Abstract: imageObjective: Although available evidence supports the protective effects of walking on hypertension – a major risk factor for cardiovascular disease and stroke – more information is needed in determining whether walking pace independently provides additional hypertension risk reductions. This prospective study determined the association between self-reported walking pace and the incidence of hypertension in the ‘Seguimiento Universidad de Navarra’ (SUN) cohort in Spain.Methods: Our population sample consisted of 15 357 university graduates initially free of chronic disease or hypertension. During an average follow-up time of 10.9 years, 1673 incident cases of hypertension were observed. Hazard ratios and 95% confidence intervals (95% CIs) for hypertension risk of each walking pace [slow (reference), normal, brisk and very brisk] were estimated using Cox regression models, adjusted for multiple possible confounders. Data were collected from 1999 to 2019, and analysed in 2020.Results: Participants who walked at a very brisk pace at baseline had a substantially lower risk of developing hypertension during follow-up than those who walked at a slow pace (multivariable-adjusted hazard ratio: 0.64; 95% CI: 0.41–0.99). Inverse associations were observed also for normal (HR: 0.64; 95% CI: 0.46–0.90) and brisk walking pace (0.69; 95% CI: 0.50–0.97) as compared to slow pace, independent of other risk factors.Conclusion: Our results support that an increase in walking pace, even slightly, is inversely associated with the development of hypertension, independent of total time spent walking and other factors associated with hypertension.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Neck-to-height ratio and arterial stiffness in Chinese adults:
           cross-sectional associations in a community-based cohort
    • Authors: Yang; Xulong; Chen, Shuohua; Zhou, Zhe; Qiu, Yumin; Zhang, Jianning; Wu, Yuntao; Xing, Aijun; Huang, Zhe; Xu, Shiyue; Wu, Shouling; Tao, Jun
      Abstract: imageObjectives: The aim of this study was to investigate the association between neck-to-height ratio (NHR) and arterial stiffness in adults from a community-based Chinese cohort in a cross-sectional study.Methods: We conducted cross-sectional analysis using data from the Kailuan study, a population-based cohort research. Altogether, 18 972 individuals were included in the analysis. Brachial ankle pulse wave velocity (baPWV), anthropometric indexes and cardiovascular risk factors were recorded. Data were analyzed by multiple lineal regression model.Results: NHR was positively associated with baPWV after adjusted for age, sex, blood pressure, heart rate, BMI, waist–hip ratio, current smoking, fasting blood glucose, serum cholesterol, uric acid, high-sensitivity C reactive protein and creatinine clearance (β = 5.76, P 
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Role of arterial stiffness in the association between hand grip strength
           and cardiovascular events: the Korean Genome and Epidemiology Study
    • Authors: Kim; Woohyeun; Kim, Seong Hwan; Choi, Cheol Ung; Lee, Seung Ku; Kang, Dong Oh; Choi, Jah Yeon; Roh, Seung-Young; Na, Jin Oh; Kim, Jin Won; Kim, Eung Ju; Rha, Seung-Woon; Park, Chang Gyu; Seo, Hong Seog; Shin, Chol
      Abstract: imageBackground: Hand grip strength (HGS) has been associated with cardiovascular events. However, the exact mechanism responsible for the inverse association between HGS and cardiovascular events has not been established. The aim of this study was to assess whether arterial stiffness mediates this association.Methods: We studied 1508 participants (age; 60 ± 5, men; 47.5%) from the Ansan cohort of the Korean Genome Epidemiology Study. Participants were assessed for various parameters of arterial stiffness as well as HGS. The augmentation index (AIx) and brachial-ankle pulse wave velocity (baPWV) were evaluated by using an applanation tonometer and automated waveform analyzer, respectively. Carotid intima medial thickness (IMT) was measured by B-mode ultrasonogram with a 7.5-MHz linear array transducer. HGS was evaluated using a Jamar dynamometer.Results: With increased grip strength, AIx decreased (r = 0.437, P 
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Incremental value of carotid elasticity modulus using shear wave
           elastography for identifying coronary artery disease in patients without
           carotid plaque
    • Authors: Wang; Yonghuai; Zhao, Cuiting; Meng, Pingping; Yu, Yao; Li, Guangyuan; Kong, Fanxin; Mu, Lixin; Yang, Jun; Ma, Chunyan
      Abstract: imageBackground: Shear wave elastography (SWE) directly quantifies the local arterial wall stiffness by calculating the elastic modulus. However, whether carotid wall elastic modulus can predict obstructive coronary artery disease (CAD) is not well known. We aimed to investigate the value of carotid wall elastic modulus measured using SWE in identifying obstructive CAD.Materials and methods: We prospectively enrolled 61 patients without carotid plaque referred for clinically indicated coronary angiography. Twenty-seven (44.3%) patients were diagnosed with obstructive CAD (≥50% coronary stenosis). The elastic modulus of common carotid artery was quantified using SWE. Ankle--brachial index (ABI) and echocardiographic global cardiac calcium score (GCCS) were measured.Results: Patients with obstructive CAD had significantly higher elastic modulus than those without obstructive CAD. The maximum elastic modulus (EMmax) was independently associated with obstructive CAD after adjusting for the Framingham risk score, ABI, and GCCS. EMmax had the highest area under the curve (AUC) to identify obstructive CAD (AUC 0.70; P = 0.003). In the nested models, the model based on the Framingham risk score and ABI (χ2 = 3.74) improved by adding GCCS (χ2 = 9.95) and further improved by adding EMmax (χ2 = 15.86). Adding EMmax to the combined ABI and GCCS model increased integrated discrimination index from 0.10 to 0.19.Conclusion: Carotid wall elastic modulus measured using SWE is a useful predictor of obstructive CAD in patients without carotid plaque. We demonstrated the incremental and independent value of carotid wall elastic modulus in identifying obstructive CAD compared with clinical risk factors and other imaging predictors, including ABI and GCCS.Video abstract: Please see the video, in Supplemental Digital Content 1, for more insights from the authors.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Blood pressure control and progression of arteriosclerosis in hypertension
    • Authors: Huang; Zhe; Wang, Guodong; Jonas, Jost B.; Ji, Chunpeng; Chen, Shuohua; Yuan, Yu; Shen, Chengli; Wu, Yuntao; Wu, Shouling
      Abstract: imageObjective: Using the brachial--ankle pulse wave velocity (baPWV) as a biomarker for arteriosclerosis, we studied the effect of blood pressure (BP) and BP control on arteriosclerosis progression.Methods and results: The community-based longitudinal Kailuan study included 6552 participants [4938 (75.37%) men] with a mean follow-up of 4.62 ± 2.21 years. Hypertension was defined based on the Joint National Committee (JNC7) criteria and the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines. All study participants had hypertension and were stratified as follows according to BP at baseline and follow-up: the normal--normal [normal BP (under therapy) at baseline and final follow-up], normal--hypertensive, hypertensive--normal, and hypertensive--hypertensive groups. Using the JNC7-based hypertension definition, the annual baPWV increase was the highest (P 
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Mediterranean diet and antihypertensive drug use: a randomized controlled
    • Authors: Ribó-Coll; Margarita; Lassale, Camille; Sacanella, Emilio; Ros, Emilio; Toledo, Estefanía; Sorlí, José V.; Babio, Nancy; Lapetra, José; Gómez-Gracia, Enrique; Alonso-Gómez, Ángel M.; Fiol, Miquel; Serra-Majem, Lluis; Pinto, Xavier; Castañer, Olga; Díez-Espino, Javier; González, José I.; Becerra-Tomás, Nerea; Cofán, Montserrat; Díaz-López, Andrés; Estruch, Ramón; Hernáez, Álvaro
      Abstract: imageObjective: To examine in older individuals at high cardiovascular risk whether following a Mediterranean diet decreased the necessity of antihypertensive drugs and modulated their associated cardiovascular risk.Methods: In the PREvención con DIeta MEDiterránea study, we assessed whether volunteers randomly allocated to an intervention with a Mediterranean diet enriched with extra-virgin olive oil or nuts (relative to a low-fat control diet) disclosed differences in the risk of: initiating antihypertensive medication in nonusers at baseline (n = 2188); and escalating therapy in participants using one, two, or three drugs at baseline (n = 2361, n = 1579, and n = 554, respectively). We also assessed whether allocation to Mediterranean diet modified the association between antihypertensive drug use and incident cardiovascular events.Results: Participants allocated to Mediterranean diet interventions were associated with lower risk of initiating antihypertensive therapy [5-year incidence rates: 47.1% in the control diet, 43.0% in MedDiets; hazard ratio = 0.84, 95% CI (0.74--0.97), in a model adjusted for age, sex, and recruitment site]. Volunteers using two drugs at baseline in the Mediterranean diet intervention enriched with extra-virgin olive oil decreased their risk of therapy escalation [5-year incidence rates: 22.9% in the control diet, 20.1% in the MedDiet; hazard ratio = 0.77, 95% CI (0.60--0.99)]. Allocation to Mediterranean diet interventions attenuated the association between antihypertensive therapy at baseline and incidence of major adverse cardiovascular events (P interaction = 0.003).Conclusion: In an older population at high cardiovascular risk, following a Mediterranean diet reduced the risk of initiating or escalating antihypertensive medication and attenuated cardiovascular risk in antihypertensive drug users.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Therapeutic inertia in the management of hypertension in primary care
    • Authors: Ali; Dalia H.; Kiliç, Birsen; Hart, Huberta E.; Bots, Michiel L.; Biermans, Marion C.J.; Spiering, Wilko; Rutten, Frans H.; Hollander, Monika
      Abstract: imageBackground: Therapeutic inertia is considered to be an obstacle to effective blood pressure (BP) control.Aims: To identify patient characteristics associated with therapeutic inertia in patients with hypertension managed in primary care and to assess reasons not to intensify therapy.Methods: A Dutch cohort study was conducted using electronic health record data of patients registered in the Julius General Practitioners’ Network (n = 530 564). Patients with a diagnosis of hypertension, SBP at least 140 and/or DBP at least 90 mmHg, and one or two BP-lowering drug(s) were included. Therapeutic inertia was defined as not undertaking therapeutic action in follow-up despite uncontrolled BP. Multivariable logistic regression was used to identify characteristics associated with inertia. Furthermore, an exploratory survey was performed in which general practitioners of 114 patients were asked for reasons not to intensify treatment.Results: We identified 6400 (10% of all patients with hypertension) uncontrolled patients on one or two BP-lowering drugs. Therapeutic inertia was 87%, similar in men and women. Older age, lower systolic, diastolic and near-target SBP, and diabetes were positively associated, while renal insufficiency and heart failure were inversely related to inertia. General practitioners did not intensify therapy because they first, considered office BP measurements as nonrepresentative (27%); second, waited for next BP readings (21%); third, wanted to optimize lifestyle first (19%). Eleven percent of patients explicitly did not want to change treatment.Conclusion: Therapeutic inertia is common in primary care patients with uncontrolled hypertension. Older age, and closer to target BP, but also concurrent diabetes were associated with inertia.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Hemodynamic profiles in treatment-naive arterial hypertension and their
           clinical implication for treatment choice: an exploratory post hoc
    • Authors: Glinz; Delphine; Bläsi, Claudia; Villiger, Andrea; Meienberg, Andrea; Socrates, Thenral; Pfister, Otmar; Mayr, Michael; Haschke, Manuel; Vischer, Annina Salome; Burkard, Thilo
      Abstract: imageObjective: Noninvasive thoracic bioimpedance by the HOTMAN System estimates hemodynamic modulators and expresses them as hemodynamic profiles. Aims of this analysis were to describe hemodynamic profiles among treatment-naive hypertensive patients compared with normotensive controls and to investigate whether a hemodynamic-guided choice of therapy improves blood pressure (BP) control within 4 weeks.Method: This exploratory post hoc analysis used data of a randomized parallel-group trial including 80 outpatients with newly diagnosed arterial hypertension (AHT), randomized to four antihypertensive first-line monotherapies, and 20 age-matched and sex-matched normotensive controls. Hemodynamic profiles were measured at baseline and after four weeks of treatment. On the basis of the hemodynamic profiles, the most appropriate pharmacological treatment was determined retrospectively and patients were categorised to have received concordant (ConTG) or discordant treatment (DisTG).Results: In the hypertensive group, hypervolemia with vasoconstriction was the predominant hemodynamic profile in 48% of patients and hypervolemia without vasoconstriction in 45%, compared with 15 and 50%, respectively, in the control group. After 4 weeks of treatment, the mean (±SD) 24-h BP was 129.9 (±11.0)/81.5 (±8.0) mmHg in the DisTG vs. 133.9 (±12.3)/84.0 (±9.1) mmHg in the ConTG (P = 0.158/0.222). The mean 24-h BP reductions were −9.7 (±10.1)/−5.0 (±6.2) mmHg in the DisTG and −12.4 (±14.8)/−6.9(±6.9) mmHg in the ConTG (P = 0.353/0.223). After 4 weeks of treatment, the BP control rate was 53.7% (43/80) among all, 55.7% (29/52) in the DisTG and 48% (12/25) in the ConTG (P = 0.628).Conclusion: Our findings do not support the hypothesis that personalized treatment initiation based on hemodynamic profiles improves BP control in newly diagnosed hypertensive outpatients.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Chlorthalidone versus hydrochlorothiazide: major cardiovascular events,
           blood pressure, left ventricular mass, and adverse effects
    • Authors: Roush; George C.; Messerli, Franz H.
      Abstract: imageBackground: There is continuous debate whether chlorthalidone (CTD) and hydrochlorothiazide (HCTZ) differ in reducing major cardiovascular events (MACE). HCTZ is prescribed 10 times more commonly than CTD.Method: A systematic literature search yielded 14 references, including two network meta-analyses of randomized trials with MACE and left ventricular mass as outcomes.Results: The network meta-analysis of randomized trials showed CTD reducing MACE more than HCTZ, hazard ratio = 0.79 (0.72–0.88), P 1 year) therapy, differences in follow-up explain these discrepant results. CTD also more effectively reduced left ventricular mass in observational data and network analysis of trials. These advantages of CTD over HCTZ are consistent with greater reductions in night-time blood pressure, greater reductions in oxidative stress and platelet aggregation, and greater improvements in endothelial function.Conclusion: Over the short-term there were no differences in the net clinical benefit between HCTZ and CTD. However, long-term available data document CTD to be significantly more effective in reducing MACE than HCTZ. The Veterans Administration's trial in progress may provide definitive answer to these questions.
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Blood pressure and atrial fibrillation: a risk assessment
    • Authors: Kawada; Tomoyuki
      Abstract: No abstract available
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Reply
    • Authors: Matsumoto; Kenji; Jin, Zhezhen; Homma, Shunichi; Elkind, Mitchell S.V.; Schwartz, Joseph E.; Rundek, Tatjana; Mannina, Carlo; Ito, Kazato; Sacco, Ralph L.; Di Tullio, Marco R.
      Abstract: imageNo abstract available
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • ‘Apples to oranges’ and ‘Less is more’
    • Authors: Argyris; Antonios A.; Samara, Stamatia; Blacher, Jacques; Papaioannou, Theodoros G.; Stergiou, George S.; Vlachopoulos, Charalambos; Wassertheurer, Siegfried; Weber, Thomas; Protogerou, Athanase D.
      Abstract: No abstract available
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
  • Reply
    • Authors: Laugesen; Esben; Poulsen, Per L.
      Abstract: No abstract available
      PubDate: Tue, 01 Jun 2021 00:00:00 GMT-
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