Subjects -> MEDICAL SCIENCES (Total: 8810 journals)
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INTERNAL MEDICINE (180 journals)                     

Showing 1 - 180 of 180 Journals sorted alphabetically
Abdomen     Open Access  
ACP Hospitalist     Full-text available via subscription   (Followers: 9)
ACP Internist     Full-text available via subscription   (Followers: 10)
ACP Journal Club     Full-text available via subscription   (Followers: 11)
Acta Clinica Belgica     Hybrid Journal   (Followers: 1)
Acute and Critical Care     Open Access   (Followers: 11)
Acute Medicine     Full-text available via subscription   (Followers: 9)
Advances in Hepatology     Open Access   (Followers: 4)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6)
African Journal of Primary Health Care & Family Medicine     Open Access   (Followers: 6)
African Journal of Thoracic and Critical Care Medicine     Open Access  
American Family Physician     Full-text available via subscription   (Followers: 38)
American Journal of Hypertension     Hybrid Journal   (Followers: 31)
Anales de Medicina Interna     Open Access   (Followers: 1)
Anatomy & Physiology : Current Research     Open Access   (Followers: 9)
Angiology     Hybrid Journal   (Followers: 5)
Annals of Colorectal Research     Open Access   (Followers: 1)
Annals of Internal Medicine     Full-text available via subscription   (Followers: 392)
AORN Journal     Hybrid Journal   (Followers: 27)
Apollo Medicine     Open Access  
Archives of Drug Information     Hybrid Journal   (Followers: 5)
Archivos de Medicina Interna     Open Access   (Followers: 1)
Asia Oceania Journal of Nuclear Medicine & Biology     Open Access   (Followers: 4)
Asian Pacific Journal of Tropical Disease     Full-text available via subscription   (Followers: 3)
Australasian Physical & Engineering Sciences in Medicine     Hybrid Journal   (Followers: 1)
BMI Journal : Bariátrica & Metabólica Iberoamericana     Open Access   (Followers: 1)
BMJ Open Diabetes Research & Care     Open Access   (Followers: 35)
BMJ Quality & Safety     Hybrid Journal   (Followers: 69)
Bone & Joint Journal     Hybrid Journal   (Followers: 138)
Brain Communications     Open Access   (Followers: 4)
Brain Science Advances     Open Access  
Canadian Journal of General Internal Medicine     Open Access   (Followers: 2)
Cardiovascular Medicine in General Practice     Full-text available via subscription   (Followers: 7)
Case Reports in Internal Medicine     Open Access   (Followers: 1)
Cell Death & Disease     Open Access   (Followers: 3)
Cellular and Molecular Gastroenterology and Hepatology     Open Access   (Followers: 3)
Cephalalgia     Hybrid Journal   (Followers: 8)
Cephalalgia Reports     Open Access   (Followers: 4)
Chronic Diseases and Injuries in Canada     Free   (Followers: 1)
Clinical Ethics     Hybrid Journal   (Followers: 13)
Clinical Liver Disease     Open Access   (Followers: 5)
Clinical Nutrition     Hybrid Journal   (Followers: 98)
Clinical Thyroidology     Full-text available via subscription   (Followers: 1)
CNE Pflegemanagement     Hybrid Journal  
Communication Law and Policy     Hybrid Journal   (Followers: 5)
Current Diabetes Reports     Hybrid Journal   (Followers: 30)
Current Hepatology Reports     Hybrid Journal  
Current Research: Integrative Medicine     Open Access  
CVIR Endovascular     Open Access   (Followers: 1)
Der Internist     Hybrid Journal   (Followers: 12)
Diabetes     Full-text available via subscription   (Followers: 603)
Diabetes Care     Full-text available via subscription   (Followers: 578)
Diabetes Internacional     Open Access  
Diabetes Spectrum     Full-text available via subscription   (Followers: 17)
Diagnosis     Hybrid Journal   (Followers: 1)
Egyptian Journal of Bronchology     Open Access  
Egyptian Journal of Internal Medicine     Open Access   (Followers: 1)
Egyptian Journal of Neurosurgery     Open Access  
Egyptian Liver Journal     Open Access   (Followers: 2)
Egyptian Spine Journal     Open Access  
EMC - Aparato Locomotor     Hybrid Journal  
Endovascular Neuroradiology / Ендоваскулярна нейрорентгенохірургія     Open Access   (Followers: 1)
eNeuro     Open Access   (Followers: 3)
Ergonomics     Hybrid Journal   (Followers: 24)
European Journal of Inflammation     Open Access   (Followers: 2)
European Journal of Internal Medicine     Full-text available via subscription   (Followers: 10)
European Journal of Translational Myology     Open Access  
European Radiology Experimental     Open Access   (Followers: 2)
Head and Neck Tumors     Open Access   (Followers: 1)
Health Sociology Review     Hybrid Journal   (Followers: 14)
HemaSphere     Open Access   (Followers: 2)
Hepatology Communications     Open Access  
Hepatoma Research     Open Access   (Followers: 3)
Human Physiology     Hybrid Journal   (Followers: 5)
ImmunoHorizons     Open Access  
Immunological Medicine     Open Access  
Infectious Diseases: Research and Treatment     Open Access   (Followers: 5)
Inflammation and Regeneration     Open Access   (Followers: 2)
Inflammatory Intestinal Diseases     Open Access  
Innere Medizin up2date     Hybrid Journal   (Followers: 1)
Internal and Emergency Medicine     Hybrid Journal   (Followers: 5)
Internal Medicine Journal     Hybrid Journal   (Followers: 9)
International Journal of Abdominal Wall and Hernia Surgery     Open Access   (Followers: 1)
International Journal of Anatomy and Research     Open Access   (Followers: 2)
International Journal of Angiology     Hybrid Journal  
International Journal of Artificial Organs     Hybrid Journal   (Followers: 3)
International Journal of Hyperthermia     Open Access  
International Journal of Internal Medicine     Open Access   (Followers: 3)
International Journal of Noncommunicable Diseases     Open Access  
International Journal of Psychiatry in Clinical Practice     Hybrid Journal   (Followers: 6)
Iranian Journal of Neurosurgery     Open Access   (Followers: 1)
Italian Journal of Anatomy and Embryology     Open Access   (Followers: 1)
JAC-Antimicrobial Resistance     Open Access   (Followers: 4)
JAMA Internal Medicine     Full-text available via subscription   (Followers: 364)
JCSM Clinical Reports     Open Access   (Followers: 3)
JHEP Reports     Open Access  
JIMD Reports     Open Access  
JMV - Journal de Médecine Vasculaire     Hybrid Journal   (Followers: 1)
Joint Commission Journal on Quality and Patient Safety     Hybrid Journal   (Followers: 41)
JOP. Journal of the Pancreas     Open Access   (Followers: 2)
Journal of Basic & Clinical Physiology & Pharmacology     Hybrid Journal   (Followers: 1)
Journal of Bone Oncology     Open Access   (Followers: 1)
Journal of Cancer & Allied Specialties     Open Access  
Journal of Clinical and Experimental Hepatology     Full-text available via subscription   (Followers: 3)
Journal of Clinical Movement Disorders     Open Access   (Followers: 3)
Journal of Community Hospital Internal Medicine Perspectives     Open Access  
Journal of Cutaneous Immunology and Allergy     Open Access  
Journal of Developmental Origins of Health and Disease     Hybrid Journal   (Followers: 2)
Journal of Endoluminal Endourology     Open Access  
Journal of Gastroenterology and Hepatology Research     Open Access   (Followers: 4)
Journal of General Internal Medicine     Hybrid Journal   (Followers: 23)
Journal of Hypertension     Hybrid Journal   (Followers: 14)
Journal of Infectious Diseases     Hybrid Journal   (Followers: 48)
Journal of Interdisciplinary Medicine     Open Access  
Journal of Internal Medicine     Hybrid Journal   (Followers: 11)
Journal of Liver : Disease & Transplantation     Hybrid Journal   (Followers: 7)
Journal of Medical Internet Research     Open Access   (Followers: 24)
Journal of Movement Disorders     Open Access   (Followers: 2)
Journal of Pain and Symptom Management     Hybrid Journal   (Followers: 46)
Journal of Pancreatic Cancer     Open Access  
Journal of Renal and Hepatic Disorders     Open Access  
Journal of Solid Tumors     Open Access   (Followers: 1)
Journal of Sports Medicine and Allied Health Sciences : Official Journal of the Ohio Athletic Trainers Association     Open Access   (Followers: 1)
Journal of the American Board of Family Medicine     Open Access   (Followers: 11)
Journal of the European Mosquito Control Association     Open Access  
Journal of Translational Internal Medicine     Open Access  
Jurnal Vektor Penyakit     Open Access  
La Revue de Medecine Interne     Full-text available via subscription   (Followers: 3)
Lege artis - Das Magazin zur ärztlichen Weiterbildung     Hybrid Journal   (Followers: 1)
Liver Cancer International     Open Access  
Liver Research     Open Access  
Molecular Diagnosis & Therapy     Hybrid Journal   (Followers: 3)
Molecular Therapy - Oncolytics     Open Access  
Multiple Sclerosis and Demyelinating Disorders     Open Access   (Followers: 7)
MYOPAIN. A journal of myofascial pain and fibromyalgia     Hybrid Journal   (Followers: 18)
Neuro-Oncology Advances     Open Access   (Followers: 1)
Neurobiology of Pain     Open Access   (Followers: 2)
Neurointervention     Open Access   (Followers: 6)
Neuromuscular Diseases     Open Access  
Nigerian Journal of Gastroenterology and Hepatology     Full-text available via subscription  
OA Alcohol     Open Access   (Followers: 5)
Oncological Coloproctology     Open Access  
Open Journal of Internal Medicine     Open Access  
Pleura and Peritoneum     Open Access  
Pneumo News     Full-text available via subscription  
Polish Archives of Internal Medicine     Full-text available via subscription   (Followers: 2)
Preventing Chronic Disease     Free   (Followers: 2)
Progress in Transplantation     Hybrid Journal   (Followers: 1)
Prostate International     Open Access   (Followers: 2)
Psychiatry and Clinical Psychopharmacology     Open Access   (Followers: 1)
Pulmonary Therapy     Open Access   (Followers: 2)
Quality of Life Research     Hybrid Journal   (Followers: 20)
Research and Practice in Thrombosis and Haemostasis     Open Access  
Revista Chilena de Fonoaudiología     Open Access   (Followers: 1)
Revista de la Sociedad Peruana de Medicina Interna     Open Access   (Followers: 4)
Revista del Instituto de Medicina Tropical     Open Access  
Revista Hispanoamericana de Hernia     Open Access   (Followers: 1)
Revista Médica Internacional sobre el Síndrome de Down     Full-text available via subscription   (Followers: 1)
Revista Virtual de la Sociedad Paraguaya de Medicina Interna     Open Access   (Followers: 1)
Romanian Journal of Diabetes Nutrition and Metabolic Diseases     Open Access   (Followers: 1)
Romanian Journal of Internal Medicine     Open Access  
Russian Journal of Child Neurology     Open Access   (Followers: 1)
Scandinavian Journal of Primary Health Care     Open Access   (Followers: 8)
Schlaf     Hybrid Journal  
Schmerzmedizin     Hybrid Journal  
Scientific Journal of the Foot & Ankle     Open Access   (Followers: 1)
SciMedicine Journal     Open Access   (Followers: 3)
SEMERGEN - Medicina de Familia     Full-text available via subscription   (Followers: 1)
The Journal of Critical Care Medicine     Open Access   (Followers: 9)
Therapeutic Advances in Chronic Disease     Open Access   (Followers: 8)
Therapeutic Advances in Musculoskeletal Disease     Hybrid Journal   (Followers: 6)
Thieme Case Report     Hybrid Journal   (Followers: 1)
Tijdschrift voor Urologie     Hybrid Journal  
Tissue Barriers     Hybrid Journal   (Followers: 1)
Transactions of the Royal Society of Tropical Medicine and Hygiene     Hybrid Journal   (Followers: 3)
Transgender Health     Open Access   (Followers: 3)
Trends in Anaesthesia and Critical Care     Full-text available via subscription   (Followers: 23)
US Cardiology Review     Open Access  
Vascular and Endovascular Review     Open Access   (Followers: 1)
Ожирение и метаболизм     Open Access  


Similar Journals
Journal Cover
Human Physiology
Journal Prestige (SJR): 0.165
Number of Followers: 5  
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1608-3164 - ISSN (Online) 0362-1197
Published by Springer-Verlag Homepage  [2657 journals]
  • Atypical Clinical Cases of Cerebral Autosomal Dominant Arteriopathy with
           Subcortical Infarcts and Leukoencephalopathy (CADASIL)
    • Abstract: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary CNS disease with autosomal dominant inheritance caused by NOTCH3 gene mutations. Typically, CADASIL manifests with headaches, recurrent strokes, and progressive cognitive decline. Neuroimaging plays an important diagnostic role as it reveals multiple lacunar infarcts in the basal ganglia, brainstem, and cerebellum, as well as focal white matter lesions and diffuse leukoaraiosis-type changes. CADASIL can sometimes have other symptoms and mimic different phenotypes atypical of the disease. We hereby present two genetically confirmed CADASIL cases that manifested with predominantly cerebellar or essential tremor combined with cognitive and affective disturbances. The main principles of diagnosis of this disease characterized by clinical polymorphism are discussed.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718080078
  • Assessment of Civil Flying Personnel Labor Intensity within a Special
           Working Conditions Assessment
    • Abstract: In recent years expert communities have been debating actively issues of assessing civil pilots’ working conditions with the focus on labor intensity. Objectivity of the assessment of flight and cabin crews job sites can be improved using the evidence of links between a job hazard class determined by labor intensity and objective physiological changes or a long-term decline of occupational health and longevity gathered in aerospace medicine, labor and industrial ecology medicine. The authors give a summary of their recommendation for revision of the labor safety regulations.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718070022
  • Mineral Bone Density and Body Composition of Participants in Experiment
    • Abstract: The investigation of the bone system and body composition in the participants of the Mars-500 experiment (prior to and on completion of the experiment) employed dual-energy X-ray absorptiometry (DXA) using a HOLOGIC Delphy osteodensitometer according to the protocol used in examination of cosmonauts. The bone density of lumber vertebrae and femoral proximal epiphysis, as well as the body composition were measured. Statistically significant changes in the mineral density of lumber vertebrae were found in three subjects and displayed different trends from +2.6 to –2.4%. At the same time, in the femoral proximal epiphysis, including in the cervical region, the mineral density after the experiment was significantly lower in all participants. Four subjects exhibited an increase (by 5–9%) in the mineralization of the skull bones, as in some cosmonauts after flights. All participants were characterized by loss of adipose tissue mass (from 2 to 7 kg; in one subject, 20 kg, by a factor of three). Changes in lean mass (by 1–3 kg) were often negative and in the limbs might be associated with preferences for a certain type of physical activity. It is shown that prolonged stay in a confined space can lead to a decrease in mineralization of individual parts of the skeleton. Unlike real spaceflights and long-duration experiments with hypokinesia carried out earlier at the Institute for Biomedical Problems, no clinically significant loss of mineral density (osteoporosis, osteopenia) was observed in the Mars-500 experiment, which may be due to the lack of microgravity effects.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718070101
  • Professionally Important Skills of Air Traffic Controllers
    • Abstract: The paper deals with the diagnosis and development of core skills of air traffic (AT) controllers based on a professiogram analysis of their work. The aim was to assess how professional skills are related to experience and to explore the opportunities of purposeful training of these skills. The study was conducted with the participation of air traffic (AT) controllers who were graduates of an ATC school aged 22–25 years and had no experience and eleven first-class operators aged 31–37 years with eight to ten years of experience. The professiogram analysis of work was carried out using a specially crafted skill tests battery followed by training (ten sessions during ten school days) for inexperienced air traffic controllers, which was tied up to regular refresher training. The study pinpointed the core skills that were improved significantly by the special training and proved the possibility of their development using a training cycle during planned teaching.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718070150
  • Effects of Physical Loads in Supine Position on Intraocular Pressure
    • Abstract: The subjects were 19 young powerlifters aged from 18 to 30 years. Strength training, namely, the jerk in the supine position, was performed either breathing in the usual way or holding breath simultaneously with straining. Ophthalmoscopy, laser scanning ophthalmoscopy, and intraocular pressure measurements using a pneumatic tonometer were conducted before, during, and after training. After jerks, intraocular pressure elevation was observed in all subjects; in three subjects, the ophthalmic tone overpassed normal values. The ophthalmic tone was fitness-dependent and lower in well-trained subjects. Ophthalmoscopy of physically unfit subjects showed an increase in retinal vein diameters, disappearance of spontaneous venous pulsation in the optic disk in four subjects, and exaggerated hyperemia of the optic papilla. The incentive for the investigation was documented unfavorable changes in the human visual organ in long-duration space missions.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718070083
  • Cell Immunity Indices in Crew Members of the Moon-2015 Project
    • Abstract: Cell immunity indices were studied in 6 female participants in the Moon-2015 project at the age of 25 to 34 years. Peripheral blood was analyzed for lymphocyte subtypes CD3+, CD3+CD4+, CD3+CD8+, CD19+, and CD3–CD16+CD56+ and monocytes and granulocytes that express signal recognition receptors of the Toll-like (TLR) family (TLR2, TLR4, TLR6) localized on the surface of cells. The results of the study have demonstrated a distinct effect of short-term isolation on the immune system ability to mobilize. Rotation on a short-arm centrifuge (SAC) together with a nine-day isolation in a chamber caused diverse responses of the adaptive and innate immune systems. Apparently, the changes observed reflect a complex adaptation process in the innate and acquired immunity at the early stage of adaptation to isolation and also to the exposure to +Gz accelerations (head-to-pelvis) during rotations on SAC.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718070125
  • Prevention of Cerebrovascular Disease in Patients with Myeloproliferatie
    • Abstract: Introduction. Hemorheological abnormalities in patients with Ph-negative myeloproliferative disorders (MPD) may lead to the development and/or progression of cerebrovascular pathology. Adequate preventive therapy in such cases lowers the risk of cerebral thrombotic complications. Objective. Evaluation of the effect of dipyridamole and acetylsalicylic acid (ASA) on platelet and erythrocyte aggregation, as well as on morphofunctional properties of erythrocytes in patients with cerebrovascular disease (CVD) due to MPD. Materials and methods. The study comprised 40 patients with various forms of CVD and Рh-negative MPD: 20 patients received dipyridamole, and 20 received ASA for prevention of cerebral thrombotic complications. Mean patient’s age was 44.6 years [35; 58.5]. A thorough clinical and neurological examination was performed, as well as neuroimaging studies, coagulation tests, analysis of platelet aggregation and rheological properties of erythrocytes. Results. Within the observation period (median—6.3 months) no acute cerebrovascular events in both groups were registered. Platelet aggregation (induced by ADP or adrenaline) was similar in both groups. Dipyridamole and ASA were also similar in their effect on functional properties of erythrocytes. Conclusion. Our findings suggest that the therapeutic effect of dipyridamole concerning CVD is similar to that of ASA. Dipyridamole can be recommended for use in patients with Рh-negative MPD if other antiplatelet agents are contraindicated.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718080133
  • Effect of Repeated Space Flights on Ocular Tracking
    • Abstract: This paper reports the results of studying the vestibular and ocular intersensory interactions and eye tracking function in 32 cosmonauts on maiden and repeated missions to the International Space Station. Mission duration ranged from 125 to 215 days. The cosmonauts were tested twice pre launch (baseline data collection) and on days R + 1/2, R + 4/5, and R + 8/9. Video oculography was used to test eye movements. It was found that in the majority of cosmonauts who had no experience of long-duration space missions the eye tracking function remained significantly impaired untill day R + 8/9. In cosmonauts who had already encountered microgravity, obvious changes in eye tracking were observed on day R + 1/2 only and, residual, on day R + 4/5. During post-flight recovery, a new eye tracking strategy was acquired only by cosmonauts who had the first experience of spaceflight microgravity.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718070095
  • Human Tolerance of G-Loads in Space Missions and Artificial Gravity
    • Abstract: —Adilya Ravgatovna Kotovskaya is a head of laboratory of the Institute of Biomedical Problems of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Member of the International Academy of Astronautics, a specialist in the field of gravitational physiology and medicine. Prof. Kotovskaya is one of the founders of space biology and medicine in Russia. She took an active part in the preparation of the first animal flight (Laika) on the second artificial earth satellite and biological experiments on board satellite vehicles. Prof. Kotovskaya participated in the selection and preparation of the first cosmonaut Yu.A. Gagarin and other cosmonauts for missions on the Vostok, Voskhod, and Soyuz spaceships. She is a veteran of the Great Patriotic War, awarded with two Orders of the Red Banner of Labor and other national and foreign orders and medals. Prof. Kotovskaya is an honorary citizen of Toulouse. The editorial board of the journal sincerely congratulates Prof. Kotovskaya on her ninetieth birthday and wishes her good health and many years of active life.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718070058
  • Assessment of the Effects of Cell Therapy on Reproduction of the
           Conditioned Passive Avoidance Reflex in Rats with Quinoline-Induced Model
           of Huntington’s Disease
    • Abstract: Introduction: The model involving injection of quinolinic acid (QA) into the rat striatum simulates many clinical and morphological characteristics of Huntington’s disease (HD). Searching for effective treatment methods is rather important because of the fatality of HD. One of such methods is to create a neuroprotective environment to slow down the current degenerative process and/or replace dead neurons. In particular, this can be performed by transplantation of cells capable of neuronal differentiation and integration into the proper structural and functional brain networks. Objective: To assess effectiveness and safety of transplantation of neural precursor cells differentiated from induced pluripotent stem cells (iPSCs) taken from a healthy donor into the striatum of rats with QA-induced model of HD. Materials and methods: The effects of neurotransplantation on reproduction of the conditioned passive avoidance reflex were studied in rats with the HD model induced by injection of QA into the caudate nuclei of the striatum. In the study group (n = 8), human neural progenitors (1 × 106 per 10 µL of normal saline unilaterally, on the injured side) derived from iPSCs taken from a healthy donor were injected into the caudate nuclei as the transplanted material; normal saline was injected to the control group. The conditioned passive avoidance responses were tested with the ShutАvoid 1.8.03 software on a Harvard apparatus (Panlab, Spain). Results: When testing the reproduction of the passive avoidance responses, we found that injection of QA into the caudate nuclei of the rat brain reliably reduced the conditioned responses. Neurotransplantation of neural progenitors derived from iPSCs had a clear therapeutic effect and reinforced the passive avoidance reflex. During the entire testing period (7 days after exposure to the pain stimulus), the experimental animals either did not visit the dark compartment at all or visited it with a long latency period. Conclusions: Experimental neurotransplantation using iPSC derivatives allowed to improve storage of trace memory in rats with QA-induced model of HD, which contributes to correction of cognitive impairments caused by administration of the neurotoxin.
      PubDate: 2018-12-01
      DOI: 10.1134/S036211971808011X
  • Optimization of Early Rehabilitation of Patients with Ischemic Stroke and
           Sleep-Disordered Breathing
    • Abstract: Introduction: Sleep-disordered breathing (SDB) is detected in 70% of stroke patients and impedes functional rehabilitation; it also increases the length of hospital stay and the risk of stroke recurrence and fatal outcome. Objective: To study the dynamics of SDB in its correlation with neurological disorders in stroke patients and to develop the approaches to optimization of early rehabilitation. Materials and methods: Seventy eight patients with acute ischemic stroke were examined. SDB was verified by cardiorespiratory monitoring; neurological deficit was assessed with the NIHSS and mRS scales. Examination was performed upon admission (days 2–5 post stroke) and repeated 3 weeks after. The effect of SDB correction on neurological recovery was studied for positional therapy (elevated head of bed by 30°) in combination with oxygen therapy (insufflation of O2 with maintenance of saturation level not less than 95% under digital sensor control). Results: Upon admission, SDB was revealed in 88% of patients; moderate and severe disorders being predominant (the apnea/hypopnea index (AHI) ≥ 15 h–1), most frequently presenting as obstructive apnea. In patients with AHI < 15 h–1, the positive dynamics of neurological disorders (p < 0.04) was observed along with stable SDB parameters. Neurological improvement (р < 0.05) was present in patients with AHI ≥ 15 h–1, which was associated with lesser severity of SDB. A direct correlation between the severity of neurological disorders and AHI after 3 weeks from the onset was revealed: RNIHSS/AHI = 0.45 (р = 0.003) and RmRS/AHI = 0.44 (р = 0.004). Patients with AHI ≥ 15 h–1 were divided into 2 groups: group A (no interventions) and group B (with application of positional and oxygen therapy in the night sleep during 7 days). A positive effect of therapy on restoration of neurological functions, along with a decrease in AHI, was revealed. Conclusions: SDB is a frequent and persistent disorder in patients with ischemic stroke. Early detection and correction of SDB should be regarded as an important component of post-stroke rehabilitation.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718080066
  • Structural and Functional Neuroimaging in Amyotrophic Lateral Sclerosis
    • Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal progressive disorder of the central nervous system affecting the upper and lower motor neurons. It is important to study the specific nature of the disease course and the character of neurodegenerative process expansion in ALS, since no effective methods of treatment for this disease have been developed yet. Despite the clear evidence of multisystem brain damage in ALS, there are no objective biomarkers of the upper motor neuron lesion and extramotor brain areas involvement. In recent years, structural and functional neuroimaging, such as MR-morphometry, diffusion-tensor magnetic resonance imaging, MR spectroscopy, functional MRI, positron emission tomography (PET), etc., have been playing a significant role in research on ALS. This review analyzes the results of neuroimaging methods in the context of their application for diagnostics, prediction, and monitoring the ALS course. The most sensitive and specific techniques to diagnose the disease are diffusion-tensor MRI, MR spectroscopy, PET, a combination of several neuroimaging methods, and neuroimaging with transcranial magnetic stimulation. Diffusion-tensor MRI and MR spectroscopy can be used to monitor and predict the disease course. The main limitations and weak points of the published studies on this topic, as well as the prospective for neuroimaging in ALS, are discussed.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718080029
  • Electrophysiological Techniques for Motor Unit Number Estimation
    • Abstract: Various neurological diseases involving motor neurons damage lead to a decrease in the number of functioning motor units (MUs). Accurate estimation of the number of intact MUs plays significant role in evaluating motor neuron death. Quantitative analysis of MUs by methods of routine electromyography is usually not possible. Therefore, electrophysiological techniques for MU number estimation (so-called motor unit number estimation, MUNE), have been rapidly developing over the past decades. The first article on MUNE was published in 1971. Promising, accurate, and less time-consuming modifications have been developed since, and new methods for counting MU have been proposed. In recent years, one can see increasing interest in MUNE explained by the ongoing research on new possibilities of motor neuron disease treatment, and evaluation of their effectiveness, dynamic control of the disease. Today, MUNE is considered to be a potential biomarker in many clinical trials involving patients with motor neuron disease. This review provides in sights on available MUNE techniques, describes their comparative characteristics, advantages and disadvantages of each method and their application perspectives.
      PubDate: 2018-12-01
      DOI: 10.1134/S036211971808008X
  • Effect of Three-minute Cold Exposure in Cryosauna at –70°C on the Human
           Cellular Immune System
    • Abstract: Cell components of the adaptive and innate immunity were investigated in essentially healthy volunteers aged 27 to 34 years. Peripheral blood was analyzed for absolute and relative counts of lymphocyte phenotypes CD3+, CD3+CD4+, CD3+CD8+, CD19+, CD3–CD16+CD56+, CD3+CD16+CD56+, CD3+CD25+, CD45RA+, CD4+CD45RA+, and monocytes and granulocytes expressing pattern recognition receptors of the Toll-like family (TLR2, TLR4, TLR6) on the cellular membrane. A single cold exposure at –70°С was found to affect cell factors of the human immune system dramatically. Very low temperatures produce different changes in adaptive and congenital components of immunity representing a complex process triggered by the stress-reaction to a short stay in air cryosauna.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718070137
  • Surgical Treatment of the Carpal Tunnel Syndrome with the Application of
           Endoscopic and Electrophysiological Monitoring
    • Abstract: Introduction. Carpal tunnel syndrome (CTS) is a variant of tunnel neuropathy, which develops as a result of compression of the median nerve by a hypertrophic flexor retinaculum. Surgical treatment consists in the dissection of the flexor retinaculum which leads to fast pain alleviation and termination of neurologic deficit progression. Objective. To evaluate effectiveness of the new surgical treatment of CTS with endoscopic and electrophysiological monitoring. Materials and methods. Outcomes of the surgical treatment with the new combined technique were evaluated in a group of 72 patients. To assess effectiveness, visual analogue scale (VAS) for pain, frequency of complications and relapses, length of in-hospital stay, and temporary disability were assessed. Results. We found a significant reduction in VAS pain score from 6 [3; 7] to 2 [1; 3] points within the first day following surgery along with improvement of the skin pain sensitivity from 3 [2; 4] to 2 [2; 3] points. No significant complications and relapses were registered (N = 0). The average period of hospitalization was 16 [12; 24] hours and the temporary incapacity for work was 7 [5; 12] days. Conclusions. The new surgical approach significantly reduces level of pain syndrome and sensory disturbances, allows to achieve sufficient decompression of the nerve with minimal risks of complications, and reduce duration of in-hospital stay and temporary disability.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718080145
  • PET-CT in Early Detection of Alzheimer’s Disease: A Case Report
    • Abstract: The article describes a clinical case of a female patient with Alzheimer’s disease at an early stage of the neurodegenerative process. The patient did not have any complaints. She was taken to the neuropsychologist by her husband who was concerned by the patient’s family history (his mother-in-law suffered from Alzheimer’s disease) and some memory problems that his wife had recently encountered. The diagnosis was suspected based on the results of neuropsychological evaluation of cognitive functions corresponding to mild cognitive impairment. To confirm the presence of a neurodegenerative disease, brain positron-emission tomography with F-18 fluorodesoxyglucose (FDG) was performed. Hypometabolism of the radio-tracer was detected in the cortex of temporal and parietal lobes, in the association cortex of the left temporal and the right occipital lobes, and in the posterior part of the left cyngulate gyrus. These findings correlated with the patient’s cognitive evaluation and thus provided the nosological diagnosis at an early stage of the disease.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718080108
  • Assessment of the Effect of Dynamic Light-emitting Diode Illumination on
           the Functional State of Visual Analyzer in an Environmentally Controlled
    • Abstract: This paper presents the results of studying the psychophysiological and morphofunctional state of the visual analyzer of eight male subjects after being exposed to 11-day-long dynamic light-emitting diode illumination under hermetic chamber conditions. A comprehensive eye examination did not reveal any significant effect of the short-term (not more than 11 days) exposure to artificial LED light; however, the psychophysiological characteristics of the visual analyzer function were impaired. Loss of relative accommodation and the narrowing of peripheral visual fields for green and blue may be due to asthenopia (visual fatigue) developing in closed space. Electrophysiological investigations have revealed a P100 bifurcation, which indicates changes in the morphology of the pattern-reversal visual evoked potentials (VEPs). This phenomenon may be representative of a temporal discord of visual channels or a change in their temporal characteristics caused by specific artificial illumination conditions.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718070149
  • Absence of H-Reflex as an Additional Neurophysiological Sign of the
           Development of Acute Inflammatory Demyelinating Polyneuropathy in Children
    • Abstract: Introduction. Early diagnosis of acute inflammatory demyelinating polyneuropathy (AIDP) is of fundamental importance for the timely administration of therapy. At early stages of this condition, conventionally used electrophysiological diagnostic techniques are not sensitive enough. The objective of this work was to study H-reflex as a potential tool for early diagnosis of AIDP in children. Materials and methods. A total of 57 children were examined: 20 healthy children (7–14 years; mean age 12 years) and 37 patients diagnosed with AIDP (8−13 years; mean age 11 years). Electroneuromyography (ENMG) was performed on the 3d–7th day after the first symptoms onset. Nerve conduction velocity for motor fibers, amplitude of M-response during stimulation of n. tibialis, n. ulnaris and n. medianus, as well as latency and threshold of M-response and H-reflex during stimulation of m. soleus, were evaluated. Results. No significant intergroup differences in amplitudes of motor responses and the nerve conduction velocity were recorded, while the residual latency of M-response was significantly higher in the AIDP group. In individuals of the control group, the H-reflex was recorded in 100% of cases, while being recorded only in 2 (5.4%) patients in the AIDP group. In the latter two patients, the study was performed at the earliest stage (3d day) after the onset of the first symptoms. Conclusions. In pediatric patients with AIDP, on the 3d–7th day after the first symptoms onset, H-reflex was absent in 94.6% of cases. Evaluation of the H-reflex at the early stage of AIDP in children can be used as an additional diagnostic criterion.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718080157
  • Personified Approaches to Reperfusion Therapy of Ischemic Stroke
    • Abstract: Introduction: Systemic thrombolytic therapy (STLT) with recombinant tissue plasminogen activator (rtPA) is the “gold standard” of reperfusion therapy in certain patients with ischemic stroke during the first 4.5 h after stroke onset. Objective: To assess the clinical (severity of neurological symptoms) and laboratory (complete blood cell count test) factors that affect the disease outcome after STLT. Materials and methods: Seventy patients (48 males and 22 females) aged 61 [54; 69] years with ischemic stroke who received rtPA therapy at a dose of 0.9 mg/kg were prospectively studied. Blood for the complete blood count test including neutrophil and lymphocyte counts was sampled before the thrombolytic therapy. The severity of neurological impairment was assessed using the NIH Stroke Scale (NIHSS). The functional outcome was assessed 3 months after stroke with the modified Rankin scale (mRS). ROC analysis was used to reveal factors of unfavorable outcome in acute phase of ischemic stroke (mRS score ≥ 3). Results: Severity of neurological deficit was assessed according to the NIHSS at admission was 15 [11; 17] points. Time between the manifestation of neurological symptoms and admission to the hospital was 138 [117; 170] min, and time between admission and initiation of STLT (the door-to-needle time), was 40 [30; 55] min. An unfavourable functional outcome of systemic thrombolytic therapy can be predicted according to the results of ROC analysis: the NIHSS score upon admission 12 or higher (sensitivity, 94%; specificity, 57%); neutrophil count, >7.8 × 109/L (sensitivity, 45.5%; specificity, 90.6%); lymphocyte count < 1.8 × 109/L (sensitivity, 81.8%; specificity, 59.4%). Conclusions: Personalized approach to systemic thrombolytic therapy may help to predict its effectiveness and contribute the development of more reliable strategies of patient management. Patients with potentially unfavorable outcome after intravenous thrombolysis can be the target group for mechanical reperfusion techniques such as thrombus extraction.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718080030
  • The Association between Psychological Stability and Successful
           Interpersonal Interaction in Isolation: Theoretical and Methodical Aspects
    • Abstract: Theoretical definitions of psychological stability of an individual are examined with the emphasis on the main components of this complex characteristic. The focus is laid on the aspects of adaptation in a team, in particular, the effect of psychological stability on the preferred styles of interpersonal interactions in isolation and confinement. We outline a three-stage psychological stability analysis at the cognitive, physiological, and behavior levels and describe the suite of tests used at the Institute of Biomedical Problems in the experiments with simulation of some spaceflight factors (2011–2016) to collect objective data on the strength and dynamics of personal psychological stability and its relevance to successful interaction within an isolated group.
      PubDate: 2018-12-01
      DOI: 10.1134/S0362119718070071
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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