Subjects -> MEDICAL SCIENCES (Total: 8803 journals)
    - ALLERGOLOGY AND IMMUNOLOGY (225 journals)
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    - CARDIOVASCULAR DISEASES (350 journals)
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    - GERONTOLOGY AND GERIATRICS (142 journals)
    - HEMATOLOGY (159 journals)
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    - INTERNAL MEDICINE (178 journals)
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    - SURGERY (412 journals)
    - UROLOGY, NEPHROLOGY AND ANDROLOGY (159 journals)

INTERNAL MEDICINE (178 journals)                     

Showing 1 - 180 of 180 Journals sorted alphabetically
Abdomen     Open Access  
ACP Hospitalist     Full-text available via subscription   (Followers: 9)
ACP Internist     Full-text available via subscription   (Followers: 10)
ACP Journal Club     Full-text available via subscription   (Followers: 11)
Acta Clinica Belgica     Hybrid Journal   (Followers: 1)
Acute and Critical Care     Open Access   (Followers: 11)
Acute Medicine     Full-text available via subscription   (Followers: 9)
Advances in Hepatology     Open Access   (Followers: 4)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6)
African Journal of Primary Health Care & Family Medicine     Open Access   (Followers: 6)
African Journal of Thoracic and Critical Care Medicine     Open Access  
American Family Physician     Full-text available via subscription   (Followers: 38)
American Journal of Hypertension     Hybrid Journal   (Followers: 31)
Anales de Medicina Interna     Open Access   (Followers: 1)
Anatomy & Physiology : Current Research     Open Access   (Followers: 9)
Angiology     Hybrid Journal   (Followers: 5)
Annals of Colorectal Research     Open Access   (Followers: 1)
Annals of Internal Medicine     Full-text available via subscription   (Followers: 392)
AORN Journal     Hybrid Journal   (Followers: 27)
Apollo Medicine     Open Access  
Archives of Drug Information     Hybrid Journal   (Followers: 5)
Archivos de Medicina Interna     Open Access   (Followers: 1)
Asia Oceania Journal of Nuclear Medicine & Biology     Open Access   (Followers: 4)
Asian Pacific Journal of Tropical Disease     Full-text available via subscription   (Followers: 3)
Australasian Physical & Engineering Sciences in Medicine     Hybrid Journal   (Followers: 1)
BMI Journal : Bariátrica & Metabólica Iberoamericana     Open Access   (Followers: 1)
BMJ Open Diabetes Research & Care     Open Access   (Followers: 35)
BMJ Quality & Safety     Hybrid Journal   (Followers: 69)
Bone & Joint Journal     Hybrid Journal   (Followers: 139)
Brain Communications     Open Access   (Followers: 4)
Brain Science Advances     Open Access  
Canadian Journal of General Internal Medicine     Open Access   (Followers: 2)
Cardiovascular Medicine in General Practice     Full-text available via subscription   (Followers: 7)
Case Reports in Internal Medicine     Open Access   (Followers: 1)
Cell Death & Disease     Open Access   (Followers: 3)
Cellular and Molecular Gastroenterology and Hepatology     Open Access   (Followers: 3)
Cephalalgia     Hybrid Journal   (Followers: 8)
Cephalalgia Reports     Open Access   (Followers: 4)
Chronic Diseases and Injuries in Canada     Free   (Followers: 1)
Clinical Ethics     Hybrid Journal   (Followers: 13)
Clinical Liver Disease     Open Access   (Followers: 5)
Clinical Nutrition     Hybrid Journal   (Followers: 98)
Clinical Thyroidology     Full-text available via subscription   (Followers: 1)
CNE Pflegemanagement     Hybrid Journal  
Communication Law and Policy     Hybrid Journal   (Followers: 5)
Current Diabetes Reports     Hybrid Journal   (Followers: 30)
Current Hepatology Reports     Hybrid Journal  
Current Research: Integrative Medicine     Open Access  
CVIR Endovascular     Open Access   (Followers: 1)
Der Internist     Hybrid Journal   (Followers: 12)
Diabetes     Full-text available via subscription   (Followers: 603)
Diabetes Care     Full-text available via subscription   (Followers: 577)
Diabetes Internacional     Open Access  
Diabetes Spectrum     Full-text available via subscription   (Followers: 17)
Diagnosis     Hybrid Journal   (Followers: 1)
Egyptian Journal of Bronchology     Open Access  
Egyptian Journal of Internal Medicine     Open Access   (Followers: 1)
Egyptian Journal of Neurosurgery     Open Access  
Egyptian Liver Journal     Open Access   (Followers: 2)
Egyptian Spine Journal     Open Access  
EMC - Aparato Locomotor     Hybrid Journal  
Endovascular Neuroradiology / Ендоваскулярна нейрорентгенохірургія     Open Access   (Followers: 1)
eNeuro     Open Access   (Followers: 3)
Ergonomics     Hybrid Journal   (Followers: 24)
European Journal of Inflammation     Open Access   (Followers: 2)
European Journal of Internal Medicine     Full-text available via subscription   (Followers: 10)
European Journal of Translational Myology     Open Access  
European Radiology Experimental     Open Access   (Followers: 2)
Head and Neck Tumors     Open Access   (Followers: 1)
Health Sociology Review     Hybrid Journal   (Followers: 14)
HemaSphere     Open Access   (Followers: 2)
Hepatology Communications     Open Access  
Hepatoma Research     Open Access   (Followers: 3)
Human Physiology     Hybrid Journal   (Followers: 5)
ImmunoHorizons     Open Access  
Immunological Medicine     Open Access  
Infectious Diseases: Research and Treatment     Open Access   (Followers: 5)
Inflammation and Regeneration     Open Access   (Followers: 2)
Inflammatory Intestinal Diseases     Open Access  
Innere Medizin up2date     Hybrid Journal   (Followers: 1)
Internal and Emergency Medicine     Hybrid Journal   (Followers: 5)
Internal Medicine Journal     Hybrid Journal   (Followers: 9)
International Journal of Abdominal Wall and Hernia Surgery     Open Access   (Followers: 1)
International Journal of Anatomy and Research     Open Access   (Followers: 2)
International Journal of Angiology     Hybrid Journal  
International Journal of Artificial Organs     Hybrid Journal   (Followers: 3)
International Journal of Hyperthermia     Open Access  
International Journal of Internal Medicine     Open Access   (Followers: 3)
International Journal of Noncommunicable Diseases     Open Access  
International Journal of Psychiatry in Clinical Practice     Hybrid Journal   (Followers: 6)
Iranian Journal of Neurosurgery     Open Access   (Followers: 1)
Italian Journal of Anatomy and Embryology     Open Access   (Followers: 1)
JAC-Antimicrobial Resistance     Open Access   (Followers: 4)
JAMA Internal Medicine     Full-text available via subscription   (Followers: 363)
JCSM Clinical Reports     Open Access   (Followers: 3)
JHEP Reports     Open Access  
JIMD Reports     Open Access  
JMV - Journal de Médecine Vasculaire     Hybrid Journal   (Followers: 1)
Joint Commission Journal on Quality and Patient Safety     Hybrid Journal   (Followers: 41)
JOP. Journal of the Pancreas     Open Access   (Followers: 2)
Journal of Basic & Clinical Physiology & Pharmacology     Hybrid Journal   (Followers: 1)
Journal of Bone Oncology     Open Access   (Followers: 1)
Journal of Cancer & Allied Specialties     Open Access  
Journal of Clinical and Experimental Hepatology     Full-text available via subscription   (Followers: 3)
Journal of Clinical Movement Disorders     Open Access   (Followers: 3)
Journal of Community Hospital Internal Medicine Perspectives     Open Access  
Journal of Cutaneous Immunology and Allergy     Open Access  
Journal of Developmental Origins of Health and Disease     Hybrid Journal   (Followers: 2)
Journal of Endoluminal Endourology     Open Access  
Journal of Gastroenterology and Hepatology Research     Open Access   (Followers: 4)
Journal of General Internal Medicine     Hybrid Journal   (Followers: 23)
Journal of Hypertension     Hybrid Journal   (Followers: 14)
Journal of Infectious Diseases     Hybrid Journal   (Followers: 48)
Journal of Interdisciplinary Medicine     Open Access  
Journal of Internal Medicine     Hybrid Journal   (Followers: 11)
Journal of Liver : Disease & Transplantation     Hybrid Journal   (Followers: 7)
Journal of Medical Internet Research     Open Access   (Followers: 24)
Journal of Movement Disorders     Open Access   (Followers: 2)
Journal of Pain and Symptom Management     Hybrid Journal   (Followers: 46)
Journal of Pancreatic Cancer     Open Access  
Journal of Renal and Hepatic Disorders     Open Access  
Journal of Solid Tumors     Open Access   (Followers: 1)
Journal of Sports Medicine and Allied Health Sciences : Official Journal of the Ohio Athletic Trainers Association     Open Access   (Followers: 1)
Journal of the American Board of Family Medicine     Open Access   (Followers: 11)
Journal of the European Mosquito Control Association     Open Access  
Journal of Translational Internal Medicine     Open Access  
Jurnal Vektor Penyakit     Open Access  
La Revue de Medecine Interne     Full-text available via subscription   (Followers: 3)
Lege artis - Das Magazin zur ärztlichen Weiterbildung     Hybrid Journal   (Followers: 1)
Liver Cancer International     Open Access  
Liver Research     Open Access  
Molecular Diagnosis & Therapy     Hybrid Journal   (Followers: 3)
Molecular Therapy - Oncolytics     Open Access  
Multiple Sclerosis and Demyelinating Disorders     Open Access   (Followers: 7)
MYOPAIN. A journal of myofascial pain and fibromyalgia     Hybrid Journal   (Followers: 18)
Neuro-Oncology Advances     Open Access   (Followers: 1)
Neurobiology of Pain     Open Access   (Followers: 2)
Neurointervention     Open Access   (Followers: 6)
Neuromuscular Diseases     Open Access  
Nigerian Journal of Gastroenterology and Hepatology     Full-text available via subscription  
OA Alcohol     Open Access   (Followers: 5)
Oncological Coloproctology     Open Access  
Open Journal of Internal Medicine     Open Access  
Pleura and Peritoneum     Open Access  
Pneumo News     Full-text available via subscription  
Polish Archives of Internal Medicine     Full-text available via subscription   (Followers: 2)
Preventing Chronic Disease     Free   (Followers: 2)
Progress in Transplantation     Hybrid Journal   (Followers: 1)
Prostate International     Open Access   (Followers: 2)
Psychiatry and Clinical Psychopharmacology     Open Access   (Followers: 1)
Pulmonary Therapy     Open Access   (Followers: 2)
Quality of Life Research     Hybrid Journal   (Followers: 20)
Research and Practice in Thrombosis and Haemostasis     Open Access  
Revista Chilena de Fonoaudiología     Open Access   (Followers: 1)
Revista de la Sociedad Peruana de Medicina Interna     Open Access   (Followers: 4)
Revista del Instituto de Medicina Tropical     Open Access  
Revista Hispanoamericana de Hernia     Open Access   (Followers: 1)
Revista Médica Internacional sobre el Síndrome de Down     Full-text available via subscription   (Followers: 1)
Revista Virtual de la Sociedad Paraguaya de Medicina Interna     Open Access   (Followers: 1)
Romanian Journal of Diabetes Nutrition and Metabolic Diseases     Open Access   (Followers: 1)
Romanian Journal of Internal Medicine     Open Access  
Russian Journal of Child Neurology     Open Access   (Followers: 1)
Scandinavian Journal of Primary Health Care     Open Access   (Followers: 8)
Schlaf     Hybrid Journal  
Schmerzmedizin     Hybrid Journal  
Scientific Journal of the Foot & Ankle     Open Access   (Followers: 1)
SciMedicine Journal     Open Access   (Followers: 3)
SEMERGEN - Medicina de Familia     Full-text available via subscription   (Followers: 1)
The Journal of Critical Care Medicine     Open Access   (Followers: 9)
Therapeutic Advances in Chronic Disease     Open Access   (Followers: 8)
Therapeutic Advances in Musculoskeletal Disease     Hybrid Journal   (Followers: 6)
Thieme Case Report     Hybrid Journal   (Followers: 1)
Tijdschrift voor Urologie     Hybrid Journal  
Tissue Barriers     Hybrid Journal   (Followers: 1)
Transactions of the Royal Society of Tropical Medicine and Hygiene     Hybrid Journal   (Followers: 3)
Transgender Health     Open Access   (Followers: 3)
Trends in Anaesthesia and Critical Care     Full-text available via subscription   (Followers: 23)
US Cardiology Review     Open Access  
Vascular and Endovascular Review     Open Access   (Followers: 1)
Ожирение и метаболизм     Open Access  

           

Similar Journals
Journal Cover
International Journal of Internal Medicine
Number of Followers: 3  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2326-1064 - ISSN (Online) 2326-1072
Published by SAP Homepage  [105 journals]
  • Role of Non-Invasive Ventilation in Management of H1N1 Influenza Cases: A
           Study from Western India

    • Abstract: Publication year: 2020Source: International Journal of Internal Medicine, Volume 9, Number 2Minal Shastri, Amrin Kharawala, Smeet Bhavsar, Jay Jani, Dhwani Thakar, Kalpita ShringarpureIntroduction: H1N1 Influenza is a contagious disease, often amounting to epidemics globally. Severe cases require ventilatory support as a life saving measure. The role of Non-Invasive Ventilation (NIV) as an alternative to invasive ventilation in these patients is increasing. In this study, we aim to study the clinical profile and outcome of patients on NIV support at a tertiary care center in India. Methods and design: In this retrospective study, 108 RTPCR confirmed H1N1 positive patients required NIV at a tertiary care center over a period of ten years (2009-2019). Data was collected according to a standardized proforma which included parameters like demographics, clinical features, examination findings, comorbidities, X-ray and laboratory reports. Subsequently patients were classified into two groups – those who recovered purely on non-invasive mode of ventilation and those who were shifted to the invasive mode. Chi-square test and Mann Whitney U test were used for qualitative and quantitative data respectively. A p-value of less than 0.05 was considered significant. Results: From a total of 528 hospitalized patients with H1N1 Influenza, 108 patients were subjected to non-invasive ventilation (NIV) and 22 (20.04%) of them were subsequently shifted to invasive ventilation. Co-morbidities were present in 52.8% (57/108) of the cases, most common being hypertension, followed by pregnancy. A higher pulse rate, lower respiratory rate, lower oxygen saturation along with a high median SGOT, ALP and serum bicarbonate levels were significantly associated with the patients being shifted from NIV to invasive ventilation. Conclusion: NIV was effective in preventing invasive ventilation in 86 (79.06%) of the 108 patients with H1N1 infection, while 22 (20.04%) patients still required intubation despite NIV. Hence, NIV can be considered to be used as an alternative to invasive ventilation in eligible patients with H1N1 influenza.
       
  • Sharp Syndrome: About a Diagnostic Case at the Medical- Surgical Clinic of
           the Sylvanus Olympio University Hospital in Lome

    • Abstract: Publication year: 2020Source: International Journal of Internal Medicine, Volume 9, Number 1Edem Komi Mossi, Salahoudine Maman, Abdou Razak Moukaïla, Sodjehoun Apeti, Dzidzonou Komi Nemi, Laune Odilon Blatome, Agbeko Kodjo Djagadou, Eric Gumedzoe, Abago Balaka, Awalou Mohaman DjibrilSharp syndrome is the association in a patient of symptoms identical to at least two connective tissue diseases. It is rare in black Africans. It is characterized by a clinical polymorphism that is often the cause of diagnostic delay. Sharp syndrome is associated with the presence in the blood of antinuclear antibodies with speckled fluorescence whose antigen corresponds to a ribonucleoprotein. The diagnosis is based on the use of diagnostic criteria. We report a case of Sharp syndrome in a 39-year-old patient, whose diagnosis was raised on the basis of diagnostic criteria of Alarcon-Segovia and confirmed by those of the Japanese Ministry of Health and Welfare.
       
  • Cancer in Ife-Ijesha, Southwestern Nigeria: An Account of a 20- year
           Cancer Registration from Ife-Ijesha Cancer Registry

    • Abstract: Publication year: 2020Source: International Journal of Internal Medicine, Volume 9, Number 1Abidemi Omonisi, Akinwumi Komolafe, Olufemi Adefehinti, Babatunde Olasode, Oladejo Lawal, Muheez Durosinmi, Williams OdesanmiBACKGROUND: The incidence of cancer is increasing worldwide and particularly in the sub-Saharan Africa as shown by cancer data published by World Health Organization. Nigeria like many countries in the West African region is experiencing an increase in cancer incidence, yet there is no centre exclusively devoted to cancer care and cancer research. It is said that environmental factors play a significant role in the causation of cancer, so it is important to know the pattern of cancer distribution in a specific geographical location.In Nigeria, there seems to be a changing pattern in the trends of some cancers during the last four decades. AIM & OBJECTIVE: The aim of the study is to describe the pattern of cancers seen in Ife-Ijesha zone, Southwestern Nigeria as recorded in the hospital-based Ife-Ijesha cancer registry between January 1991 to December 2010. The main objective of the study is to describe the pattern of cancer seen with reference to age, sex and site. MATERIALS AND METHODS: The study is a retrospective study of all cases of malignant tumour recorded in the Ife-Ijesha cancer registry which is located in the Department of Morbid Anatomy & Forensic Medicine of the Obafemi Awolowo University Teaching Hospitals Complex Ile-Ife, Nigeria between January 1991 and December 2010. RESULTS: The total number of cancers recorded in the 20 years period that met the inclusions criteria were 6405. Out of these, 3498 (54.6%) were seen in females while 2907 (45.4%) were seen in males. Total number of malignant tumours recorded in paediatric age group was 692 (10.8%). The common malignant tumours in males in order of decreasing frequency were prostate cancer, non-Hodgkin’s lymphoma, liver cancer and soft tissue sarcoma. In females, breast cancer was on top followed by cancer of the cervix, non-Hodgkin’s lymphoma, leukaemia and soft tissue tumours. There is an increasing trend in the incidence of breast cancer, prostate cancer and non-Hodgkin’s lymphoma. However, cervical cancer showed a decline. CONCLUSIONS: This study has shown a probable rising trend in the pattern of non-Hodgkin’s lymphoma recorded in Ife-Ijesha cancer registry. On the other hand, prostate cancer and cancer of the breast remained consistently the most frequent cancer in the males and females respectively. Lung cancer and Kaposi’s sarcoma that are commonly seen in the Northern and Eastern regions of Africa are rare in this study.
       
  • Disease Modifying Anti Rheumatic Drugs in Sudanese Patients with
           Rheumatoid Arthritis

    • Abstract: Publication year: 2020Source: International Journal of Internal Medicine, Volume 9, Number 1Sondos Abuel Nowr, Asaad Hamed, Safaa Hamid, Elnoor M. ElaagibObjectives: To know about DMARDs (Disease modifying anti rheumatic drugs) used by Sudanese rheumatoid arthritis patients, the type mostly used, single or combined and to assess functional disability by health assessment questionnaire (HAQ) and disease activity by clinical disease activity index (CDAI) with each type used and the time of initiation of DMARDs therapy from the diagnosis, also to see the effect of combined therapy on functional disability and disease activity. MaterialsandMethods: This was descriptive cross sectional study hospital based of 100 patients diagnosed as RA by the American College of Rheumatology (ACR-EURAL 2010) criteria attending different rheumatology referred clinics from Nov 2014to Jan 2015 patients were interviewed and asked about their DMARDs which type is used and when it started from the time of diagnosis then HAQ is filled and CDAI is calculated. Results: We had analyzed 100 patients the type of their DMARD, HAQ, CDAI the time of initiation of DMARDs with the diagnosis effect on HAQ and CDAI, also the effect of combined therapy on HAQ and CDAI. We found that the age between 36-45 were mostly affected and that 95% was female. 71% were using Hydroxychloroqine (HCQ), 49% Methotrexate (MTX), 6% Leflounimide (LEFLU), 2% Sulphasalzine and 3% Azathioprine (AZA). Most patients showed minimal HAQ (69.0%) score, 64% of the study population start DMARD at the time of diagnosis. About 36% used combined MTX and HCQ. Low CDAI was the most common in patients taking MTX and HCQ, also the most common score of HAQ in them was minimal score. There is no significant difference (P value 0.23) between early initiation of DMARDs and disease activity, also the difference was not significant between the time of initiation of DMARDs and HAQ score (P 0.036). There is significant difference between the use of combined DMARDs and CDAI and HAQ score (P 0.001, P 0.004) respectively. Conclusion: The most commonly used DMARDs are HCQ and MTX, Combination therapy is not widely used in the study patient, Most of the study patients show minimal functional disability assessed by HAQ. MTX and HCQ affect disease activity and functional disability almost in the same manner, patients in the study using MTX and HCQ show minimal score using HAQ, small percentage show remission and no remission with other type of DMARDs. Early initiation of DMARDs doesn’t affect functional disability and disease activity. While combination therapy of DMARDs affect both disease activity assessed by CDAI and functional disability assed by HAQ score.
       
  • Serum Vitamin D and Parathyroid Hormone as Early Diagnostic Markers of
           Target Organ Damage among Hypertensive Patients

    • Abstract: Publication year: 2019Source: International Journal of Internal Medicine, Volume 8, Number 3Eman F. Mohamed, Eman M. Abdelsalam, Shaimaa Ahmed Habib, Walaa Mohamed Shipl, Asmaa S. HassanBackground and Purpose: Vitamin D is fat-soluble steroids enhance intestinal uptake of calcium, iron, magnesium, and phosphate and is important for biological actions of cells in different tissues. Additionally, calcium homeostasis is associated with an increased risk of cardiovascular complications due to its vital role to play an important role in the regulation of blood pressure. The present study aims to assess subclinical LV mass and function in patients with essential hypertension and its association with vitamin D deficiency and parathormone excess. Methods: A retrospective study was carried out on 70 patients with elevated hypertension recruited from the Al-Zahraa Hospital, Faculty of Medicine (for Girls), Al-Azhar University with mean age (50.28±7.8) years. Vitamin D was measured using enzyme-linked immunosorbent assay (ELISA) technique, and parathormone was measured by chemiluminescence technique (Immulite 1000). Results: According to the level of vitamin D, the patients were divided into two groups. Thirty hypertensive patients with vitamin D deficiency as patients group (G1) and another 40 age, sex and BMI-matched hypertensive patients with normal vitamin D level as the control group (G2). Serum Ca, PTH, vitamin D has a highly significant difference among the two groups (p ≤ 0.001) without statistically significant difference for urea, serum, cholesterol, LDL, HDL, triglycerides. Conclusion: Subclinical target organ damage is significantly higher in hypertensive patients with vitamin D deficiency than hypertensive patients with normal vitamin D levels. Patients with vitamin D deficiency or excess PTH have higher LVMI, higher AMBP readings, a higher percent of non-dippers, and more impaired LV systolic function.
       
  • Causative Organisms of Catheter Associated Urinary Tract Infection in
           Medical Wards and Intensive Care Units

    • Abstract: Publication year: 2019Source: International Journal of Internal Medicine, Volume 8, Number 3Fawkia E. Zahran, Ahmed Ibrahim, Sawsan A. Omer, Sameh A. Elkohafy, Gamil K. MohammedBackground: Catheter associated urinary tract infection (CAUTI) is a urinary tract infection (UTI) where an indwelling catheter was in for more than two calendar days on the date of event (day one being the day of device placement). It is one of the most common hospital acquired infection and causes problems in hospitalized patients. Objectives: To review the overall occurrence of CAUTI, the demographic, clinical data and to determine the causative microorganisms of CAUTI in patients admitted in medical wards and intensive care unit (ICU) in KFHH secondary and tertiary hospital and to provide recommendations for prevention. Methods: This is cross-sectional prospective study of Catheter Associated Urinary Tract Infection (CAUTI) in medical wards and intensive care units. Only adult patients were included in this study. The data were collected from the patients ‘medical records. Results: About 30% of patients developed CAUTI; the majority of them were located in general wards. Although female had more CAUTI compared to male (33% versus 20%; P= 0.07) but the difference was not statistically significant. The most common isolated organisms among patients with CAUTI were: Candida yeasts (18%), E-coli, (3%) and pseudomonas (1%). Isolated multidrug resistant (MDR) organisms consisted about 10% of total isolated organism and most common isolated MDR organism is Vancomycin-Resistant Enterococci (VRE) 50% from total MDR. The most commonly used antibiotics for CAUTI in these patients were; ceftriaxone, linezolid, Carbepenem and Fluconazole. Conclusion: CAUTI was most common in patients admitted in wards than ICU. It was more common in females. Approximately one third of patients had CAUTI. Majority of patients had no urinary symptoms. Candida yeasts was the most common isolated microorganisms among patients with CAUTI.
       
  • Serum Cartilage Oligomeric Matrix Protein (COMP) a Biomarker of Rheumatoid
           Arthritis, Disease Activity and Knee Cartilage Thickness

    • Abstract: Publication year: 2019Source: International Journal of Internal Medicine, Volume 8, Number 2Nalgaa Abou-Elfattah Tawfik, Abeer Mohammed Abdul-Mohymen, Marwa Mohsen Ramadan, Asmaa M. El-NasserBackground: Serum cartilage oligomeric matrix protein (COMP) is a non-collagen glycoprotein produced by the cartilage, synovium, tendon, and meniscus. COMP is a reliable factor for monitoring cartilage damage. COMP has been studied as a biological marker for diagnostic and prognostic purposes. Musculoskeletal ultrasound (MSUS) imaging technology have allowed imaging of inflamed joints in rheumatoid arthritis patients. Objective: To assess the relationship between serum COMP levels and the articular cartilage damage based on sonographic knee cartilage thickness (KCT), disease activity, and other inflammatory markers in RA patients. Patients and Methods: Ninty participants were divided into two groups. Group I: Forty-five rheumatoid arthritis patients, which were subdivided according to disease activity into mild, moderate and sever, carried out from rheumatology outpatient clinic and inpatient in the Internal Medicine Department, Al-Zahraa University Hospital, all patients were female with their age ranging from 18 to 70 years with mean ± SD was (44.4±12.03). Group II: Forty-five age and sex-matched as control were included. Serum COMP level, Anti-Cyclic Citrullinated Peptides (ACCP), Rheumatoid Factor (RF), High Sensitive C- Reactive Protein (hs-CRP), were assayed. Also, sonographic knee cartilage thickness and Disease activity score (DAS28) were measured. Results: There were a highly significant increase the COMP level in the patient groups (the median is 301, and the interquartile range is 48-7954.9) in comparison to the control group (the median is 91.3, and the interquartile range is 39-146) with a P-value of 0.000, and highly significant increase the COMP level in the patient groups according to disease activity. There was a highly significant reduction of the knee cartilage thickness regarding lateral condyle (LC), medial condyle (MC) and intercondylar notch (IN) bilaterally compared with the control group. There were highly significant negative correlations between COMP and RKCTLC, RKCTIC and LKCTIC (P= 0.000), significant negative correlations between COMP and RKCTMC (P= 0.004), LKCTMC (P= 0.01), while there was no significant correlation between COMP and LKCTLC (P= 0.07), the mean of the right side was (P= 0.09) and the mean of the left side was (P= 0.22). Also, significant positive correlations between COMP and DAS28 (P= 0.03) was found. Conclusion: COMP can be used as a diagnostic biomarker for RA, based on its significant correlations with disease activity, ACCP, and knee cartilage thickness.
       
  • Dubin Johnson Syndrome with Transaminitis: A Rare Biochemical Variant

    • Abstract: Publication year: 2019Source: International Journal of Internal Medicine, Volume 8, Number 2Mehak Trikha, Dinesh C. GuptaDubin Johnson syndrome (DJS) is an autosomal recessive disorder of bilirubin metabolism. It is a very rare diseases and is characterized by persistent and fluctuating jaundice. Jaundice is aggravated by stress, pregnancy, alcoholism, infections, etc. It can be mistaken for viral hepatitis. It carries an excellent prognosis with no adverse impact on life expectancy. Its early diagnosis will help in preventing undue exposure of procedures and treatment to the patients. Here we report a case of DJS which has very occurrence.
       
  • Acute Exacerbations of COPD; A One Year Hospital-Based Study, Egypt

    • Abstract: Publication year: 2019Source: International Journal of Internal Medicine, Volume 8, Number 2Hend Kotb, Eman SobhBackground: acute exacerbations are frequent during the course of chronic obstructive pulmonary disease (COPD). They are associated with increased morbidity and mortality. The aim of the study: is to characterize the patients who are hospitalized for acute exacerbation of COPD and the factors related to frequent hospitalization. Patients and Methods: observational cohort study. One hundred and one patients admitted to our hospital for acute exacerbation of COPD over one year (group I) and equal number of patients with mild COPD exacerbation not requiring hospital admission (groupII) were studied. Results: We found that 101 patients admitted with acute exacerbation of COPD accounted for 10% of all admissions to medical departments and 2% of all admissions to our hospital. Group I patients had more advanced disease, high frequency of current smoking and comorbidities, frequent use of systemic steroids and home oxygen therapy. They had significant leukocytosis with neutrophilia, and higher partial pressure of carbon dioxide in arterial blood (paCO2). Significantly lower partial pressure of oxygen in arterial blood (PaO2), low 6-minute walking distance (6MWD) and more advanced COPD assessment test (CAT) score and BODE index. Severity of acute exacerbation of COPD, hypercapnia, previous ICU admission, low body mass index (BMI), low (6MWD), low PaO2, and the presence of comorbidities are the factors associated with increased frequency of hospital admission. Conclusion: COPD patients who had severe acute exacerbation, comorbidities, hypoxemia, hypercapnia, history of previous admission to ICU, low BMI, and impaired physical activity are more likely to be admitted to hospital during acute exacerbation of COPD.
       
  • Clinical Characteristics of Patients with Subacute Thyroiditis in a
           Tertiary Hospital

    • Abstract: Publication year: 2019Source: International Journal of Internal Medicine, Volume 8, Number 1Gulsah Elbuken, Ozge Tasgin-Yildirim, Ismail Yildiz, Sayid Shafi ZuhurIntroduction: Subacute granulomatous thyroiditis or subacute thyroiditis (ST) is characterized by neck pain or neck tenderness and physical examination usually shows diffuse enlargement and tenderness of the thyroid gland. Its etiology often involves a viral infection and ST manifestations occur during the recovery phase of this infection. In this study, we conducted a retrospective data review of 24 patients diagnosed with ST who were followed at our clinic. Patients and Results: Twenty-four patients (18 females, 6 males) with a mean age (±SD) of 41±10 years (min-max: 33-71) were followed. There was no significant age difference between males and females. Laboratory findings were as follows: mean sT4 value 2.7±1.5 ng/dL, sT3 5.5±3.3 pg/ml, TSH 0.2 ±0.4 mlU/mL, erythrocyte sedimentation rate (ESR) 82±27 mm/h, C-reactive protein (CRP) 56.4±36.5 mg/L, average leukocyte count 8762±2496/ mm3, absolute neutrophil count 5940±2390/ mm3. One patient had elevated anti-thyroid peroxidase (Anti-TPO) and four patients had elevated anti-thyroglobulin (Anti-Tg) antibody levels. The mean time from the onset of an upper respiratory tract infection until ST diagnosis was 39±28 days (min-max: 7-90), the mean duration of follow-up was 200 ±125 days (min-max: 30-370) and the mean duration of clinical manifestations of ST was 130±38 days (min-max: 65-195). Following a ST episode, 19 patients were euthyroid and 3 patients were hypothyroid. The outcome was unknown in 2 patients. Conclusion: ST affects daily life performance adversely due to symptoms of severe neck pain and difficulty swallowing. As can be seen in the case of our patients, the diagnosis of ST is rather difficult unless it is actively sought and on average, it takes 39 days to reach a definite diagnosis. Thus, ST should be considered in the presence of unexplained neck pain with ESR and CRP elevations.
       
 
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