Subjects -> MEDICAL SCIENCES (Total: 8810 journals)
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INTERNAL MEDICINE (180 journals)                     

Showing 1 - 180 of 180 Journals sorted alphabetically
Abdomen     Open Access  
ACP Hospitalist     Full-text available via subscription   (Followers: 9)
ACP Internist     Full-text available via subscription   (Followers: 10)
ACP Journal Club     Full-text available via subscription   (Followers: 11)
Acta Clinica Belgica     Hybrid Journal   (Followers: 1)
Acute and Critical Care     Open Access   (Followers: 11)
Acute Medicine     Full-text available via subscription   (Followers: 9)
Advances in Hepatology     Open Access   (Followers: 4)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6)
African Journal of Primary Health Care & Family Medicine     Open Access   (Followers: 6)
African Journal of Thoracic and Critical Care Medicine     Open Access  
American Family Physician     Full-text available via subscription   (Followers: 38)
American Journal of Hypertension     Hybrid Journal   (Followers: 31)
Anales de Medicina Interna     Open Access   (Followers: 1)
Anatomy & Physiology : Current Research     Open Access   (Followers: 9)
Angiology     Hybrid Journal   (Followers: 5)
Annals of Colorectal Research     Open Access   (Followers: 1)
Annals of Internal Medicine     Full-text available via subscription   (Followers: 392)
AORN Journal     Hybrid Journal   (Followers: 27)
Apollo Medicine     Open Access  
Archives of Drug Information     Hybrid Journal   (Followers: 5)
Archivos de Medicina Interna     Open Access   (Followers: 1)
Asia Oceania Journal of Nuclear Medicine & Biology     Open Access   (Followers: 4)
Asian Pacific Journal of Tropical Disease     Full-text available via subscription   (Followers: 3)
Australasian Physical & Engineering Sciences in Medicine     Hybrid Journal   (Followers: 1)
BMI Journal : Bariátrica & Metabólica Iberoamericana     Open Access   (Followers: 1)
BMJ Open Diabetes Research & Care     Open Access   (Followers: 35)
BMJ Quality & Safety     Hybrid Journal   (Followers: 69)
Bone & Joint Journal     Hybrid Journal   (Followers: 138)
Brain Communications     Open Access   (Followers: 4)
Brain Science Advances     Open Access  
Canadian Journal of General Internal Medicine     Open Access   (Followers: 2)
Cardiovascular Medicine in General Practice     Full-text available via subscription   (Followers: 7)
Case Reports in Internal Medicine     Open Access   (Followers: 1)
Cell Death & Disease     Open Access   (Followers: 3)
Cellular and Molecular Gastroenterology and Hepatology     Open Access   (Followers: 3)
Cephalalgia     Hybrid Journal   (Followers: 8)
Cephalalgia Reports     Open Access   (Followers: 4)
Chronic Diseases and Injuries in Canada     Free   (Followers: 1)
Clinical Ethics     Hybrid Journal   (Followers: 13)
Clinical Liver Disease     Open Access   (Followers: 5)
Clinical Nutrition     Hybrid Journal   (Followers: 98)
Clinical Thyroidology     Full-text available via subscription   (Followers: 1)
CNE Pflegemanagement     Hybrid Journal  
Communication Law and Policy     Hybrid Journal   (Followers: 5)
Current Diabetes Reports     Hybrid Journal   (Followers: 30)
Current Hepatology Reports     Hybrid Journal  
Current Research: Integrative Medicine     Open Access  
CVIR Endovascular     Open Access   (Followers: 1)
Der Internist     Hybrid Journal   (Followers: 12)
Diabetes     Full-text available via subscription   (Followers: 603)
Diabetes Care     Full-text available via subscription   (Followers: 578)
Diabetes Internacional     Open Access  
Diabetes Spectrum     Full-text available via subscription   (Followers: 17)
Diagnosis     Hybrid Journal   (Followers: 1)
Egyptian Journal of Bronchology     Open Access  
Egyptian Journal of Internal Medicine     Open Access   (Followers: 1)
Egyptian Journal of Neurosurgery     Open Access  
Egyptian Liver Journal     Open Access   (Followers: 2)
Egyptian Spine Journal     Open Access  
EMC - Aparato Locomotor     Hybrid Journal  
Endovascular Neuroradiology / Ендоваскулярна нейрорентгенохірургія     Open Access   (Followers: 1)
eNeuro     Open Access   (Followers: 3)
Ergonomics     Hybrid Journal   (Followers: 24)
European Journal of Inflammation     Open Access   (Followers: 2)
European Journal of Internal Medicine     Full-text available via subscription   (Followers: 10)
European Journal of Translational Myology     Open Access  
European Radiology Experimental     Open Access   (Followers: 2)
Head and Neck Tumors     Open Access   (Followers: 1)
Health Sociology Review     Hybrid Journal   (Followers: 14)
HemaSphere     Open Access   (Followers: 2)
Hepatology Communications     Open Access  
Hepatoma Research     Open Access   (Followers: 3)
Human Physiology     Hybrid Journal   (Followers: 5)
ImmunoHorizons     Open Access  
Immunological Medicine     Open Access  
Infectious Diseases: Research and Treatment     Open Access   (Followers: 5)
Inflammation and Regeneration     Open Access   (Followers: 2)
Inflammatory Intestinal Diseases     Open Access  
Innere Medizin up2date     Hybrid Journal   (Followers: 1)
Internal and Emergency Medicine     Hybrid Journal   (Followers: 5)
Internal Medicine Journal     Hybrid Journal   (Followers: 9)
International Journal of Abdominal Wall and Hernia Surgery     Open Access   (Followers: 1)
International Journal of Anatomy and Research     Open Access   (Followers: 2)
International Journal of Angiology     Hybrid Journal  
International Journal of Artificial Organs     Hybrid Journal   (Followers: 3)
International Journal of Hyperthermia     Open Access  
International Journal of Internal Medicine     Open Access   (Followers: 3)
International Journal of Noncommunicable Diseases     Open Access  
International Journal of Psychiatry in Clinical Practice     Hybrid Journal   (Followers: 6)
Iranian Journal of Neurosurgery     Open Access   (Followers: 1)
Italian Journal of Anatomy and Embryology     Open Access   (Followers: 1)
JAC-Antimicrobial Resistance     Open Access   (Followers: 4)
JAMA Internal Medicine     Full-text available via subscription   (Followers: 364)
JCSM Clinical Reports     Open Access   (Followers: 3)
JHEP Reports     Open Access  
JIMD Reports     Open Access  
JMV - Journal de Médecine Vasculaire     Hybrid Journal   (Followers: 1)
Joint Commission Journal on Quality and Patient Safety     Hybrid Journal   (Followers: 41)
JOP. Journal of the Pancreas     Open Access   (Followers: 2)
Journal of Basic & Clinical Physiology & Pharmacology     Hybrid Journal   (Followers: 1)
Journal of Bone Oncology     Open Access   (Followers: 1)
Journal of Cancer & Allied Specialties     Open Access  
Journal of Clinical and Experimental Hepatology     Full-text available via subscription   (Followers: 3)
Journal of Clinical Movement Disorders     Open Access   (Followers: 3)
Journal of Community Hospital Internal Medicine Perspectives     Open Access  
Journal of Cutaneous Immunology and Allergy     Open Access  
Journal of Developmental Origins of Health and Disease     Hybrid Journal   (Followers: 2)
Journal of Endoluminal Endourology     Open Access  
Journal of Gastroenterology and Hepatology Research     Open Access   (Followers: 4)
Journal of General Internal Medicine     Hybrid Journal   (Followers: 23)
Journal of Hypertension     Hybrid Journal   (Followers: 14)
Journal of Infectious Diseases     Hybrid Journal   (Followers: 48)
Journal of Interdisciplinary Medicine     Open Access  
Journal of Internal Medicine     Hybrid Journal   (Followers: 11)
Journal of Liver : Disease & Transplantation     Hybrid Journal   (Followers: 7)
Journal of Medical Internet Research     Open Access   (Followers: 24)
Journal of Movement Disorders     Open Access   (Followers: 2)
Journal of Pain and Symptom Management     Hybrid Journal   (Followers: 46)
Journal of Pancreatic Cancer     Open Access  
Journal of Renal and Hepatic Disorders     Open Access  
Journal of Solid Tumors     Open Access   (Followers: 1)
Journal of Sports Medicine and Allied Health Sciences : Official Journal of the Ohio Athletic Trainers Association     Open Access   (Followers: 1)
Journal of the American Board of Family Medicine     Open Access   (Followers: 11)
Journal of the European Mosquito Control Association     Open Access  
Journal of Translational Internal Medicine     Open Access  
Jurnal Vektor Penyakit     Open Access  
La Revue de Medecine Interne     Full-text available via subscription   (Followers: 3)
Lege artis - Das Magazin zur ärztlichen Weiterbildung     Hybrid Journal   (Followers: 1)
Liver Cancer International     Open Access  
Liver Research     Open Access  
Molecular Diagnosis & Therapy     Hybrid Journal   (Followers: 3)
Molecular Therapy - Oncolytics     Open Access  
Multiple Sclerosis and Demyelinating Disorders     Open Access   (Followers: 7)
MYOPAIN. A journal of myofascial pain and fibromyalgia     Hybrid Journal   (Followers: 18)
Neuro-Oncology Advances     Open Access   (Followers: 1)
Neurobiology of Pain     Open Access   (Followers: 2)
Neurointervention     Open Access   (Followers: 6)
Neuromuscular Diseases     Open Access  
Nigerian Journal of Gastroenterology and Hepatology     Full-text available via subscription  
OA Alcohol     Open Access   (Followers: 5)
Oncological Coloproctology     Open Access  
Open Journal of Internal Medicine     Open Access  
Pleura and Peritoneum     Open Access  
Pneumo News     Full-text available via subscription  
Polish Archives of Internal Medicine     Full-text available via subscription   (Followers: 2)
Preventing Chronic Disease     Free   (Followers: 2)
Progress in Transplantation     Hybrid Journal   (Followers: 1)
Prostate International     Open Access   (Followers: 2)
Psychiatry and Clinical Psychopharmacology     Open Access   (Followers: 1)
Pulmonary Therapy     Open Access   (Followers: 2)
Quality of Life Research     Hybrid Journal   (Followers: 20)
Research and Practice in Thrombosis and Haemostasis     Open Access  
Revista Chilena de Fonoaudiología     Open Access   (Followers: 1)
Revista de la Sociedad Peruana de Medicina Interna     Open Access   (Followers: 4)
Revista del Instituto de Medicina Tropical     Open Access  
Revista Hispanoamericana de Hernia     Open Access   (Followers: 1)
Revista Médica Internacional sobre el Síndrome de Down     Full-text available via subscription   (Followers: 1)
Revista Virtual de la Sociedad Paraguaya de Medicina Interna     Open Access   (Followers: 1)
Romanian Journal of Diabetes Nutrition and Metabolic Diseases     Open Access   (Followers: 1)
Romanian Journal of Internal Medicine     Open Access  
Russian Journal of Child Neurology     Open Access   (Followers: 1)
Scandinavian Journal of Primary Health Care     Open Access   (Followers: 8)
Schlaf     Hybrid Journal  
Schmerzmedizin     Hybrid Journal  
Scientific Journal of the Foot & Ankle     Open Access   (Followers: 1)
SciMedicine Journal     Open Access   (Followers: 3)
SEMERGEN - Medicina de Familia     Full-text available via subscription   (Followers: 1)
The Journal of Critical Care Medicine     Open Access   (Followers: 9)
Therapeutic Advances in Chronic Disease     Open Access   (Followers: 8)
Therapeutic Advances in Musculoskeletal Disease     Hybrid Journal   (Followers: 6)
Thieme Case Report     Hybrid Journal   (Followers: 1)
Tijdschrift voor Urologie     Hybrid Journal  
Tissue Barriers     Hybrid Journal   (Followers: 1)
Transactions of the Royal Society of Tropical Medicine and Hygiene     Hybrid Journal   (Followers: 3)
Transgender Health     Open Access   (Followers: 3)
Trends in Anaesthesia and Critical Care     Full-text available via subscription   (Followers: 23)
US Cardiology Review     Open Access  
Vascular and Endovascular Review     Open Access   (Followers: 1)
Ожирение и метаболизм     Open Access  


Similar Journals
Journal Cover
Journal of Clinical and Experimental Hepatology
Journal Prestige (SJR): 0.971
Citation Impact (citeScore): 2
Number of Followers: 3  
  Full-text available via subscription Subscription journal
ISSN (Print) 0973-6883 - ISSN (Online) 2213-3453
Published by Elsevier Homepage  [3303 journals]
  • Issue Highlights
    • Citation: Journal of Clinical and Experimental Hepatology 11, 3 (2021)
      PubDate: 2021-05
      DOI: 10.1016/S0973-6883(21)00094-3
      Issue No: Vol. 11, No. 3 (2021)
  • Liver Injury Associated With Drugs and Complementary and Alternative
           Medicines in India
    • Authors: Einar S. Björnsson
      Pages: 281 - 283
      Abstract: Idiosyncratic drug-induced liver injury (DILI) is an important differential diagnosis in patients with abnormal liver tests.1 The presentation is acute in the vast majority of cases, and the diagnosis is challenging. DILI is the most common cause of acute liver failure in the US2 and Europe,3 but in India, viral hepatitis is the most common cause, followed by liver injury due to antituberculosis (anti-TB) therapy.4 During the last two decades, interest in the study of DILI has increased considerably.
      Citation: Journal of Clinical and Experimental Hepatology 11, 3 (2021)
      PubDate: 2021-05
      DOI: 10.1016/j.jceh.2021.04.004
      Issue No: Vol. 11, No. 3 (2021)
  • New Developments in the Treatment of Hepatocellular Carcinoma: The Concept
           of Adjuvant and Neoadjuvant Chemotherapy
    • Authors: Anil C. Anand; Subrat K. Acharya
      Pages: 284 - 287
      Abstract: Hepatocellular carcinoma (HCC) is the commonest liver malignancy, and its annual incidence has been estimated to be 2.8 per 100,000 population in India.1 There is evidence to suggest that the incidence and prevalence of HCC are rising because of the raging epidemic of nonalcoholic fatty liver disease, and the condition is likely to become the leading cause of cancer in India in near future.2 The situation is similar in the Western world too.3 The prognosis of HCC is dismal because of several reasons.
      Citation: Journal of Clinical and Experimental Hepatology 11, 3 (2021)
      PubDate: 2021-05
      DOI: 10.1016/j.jceh.2021.04.003
      Issue No: Vol. 11, No. 3 (2021)
  • Outcomes of COVID-19 in Patients with Cirrhosis or Liver Transplantation
    • Authors: Narendra S. Choudhary; Swapnil Dhampalwar, Neeraj Saraf, Arvinder S. Soin
      Abstract: Coronavirus disease 2019 (COVID-19) is associated with a significant morbidity and mortality in patients with cirrhosis. There is a significantly higher morbidity and mortality due to COVID-19 in patients with decompensated cirrhosis as compared to compensated cirrhosis, and in patients with cirrhosis as compared to non-cirrhotic chronic liver disease. The fear of COVID-19 before or after liver transplantation has lead to a significant reduction in liver transplantation numbers, and patients with decompensated cirrhosis remain at risk of wait list mortality.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-05-11
      DOI: 10.1016/j.jceh.2021.05.003
  • Performance of leukocyte esterase reagent strips in the detection of
           spontaneous bacterial peritonitis in cirrhotic patients: a systematic
           review and meta-analysis
    • Authors: Kishan P. Patel; John P. Gallagher, Parker M. Korbitz, Cynthia Schmidt, Thammasin Ingviya, Tomoki Sempokuya, Wuttiporn Manatsathit
      Abstract: Spontaneous bacterial peritonitis (SBP) is a bacterial infection associated with a high mortality rate in cirrhotic patients. The gold standard for the detection of SBP is a manual cell count from ascitic fluid, however, alternative screening methods are under investigation. In particular, leukocyte esterase reagent strips (LERS) has been studied as an alternative method to detect SBP with a low cost and instant turnaround time. Therefore, this study aims to evaluate the performance of LERS in the detection of SBP.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-05-11
      DOI: 10.1016/j.jceh.2021.05.002
  • Principles, Interpretation and Evidence-based Role of Viscoelastic
           Point-of-Care Coagulation Assays in Cirrhosis and Liver FailureAuthors
    • Authors: Madhumita Premkumar; Anand V. Kulkarni, Kamal Kajal, Smita Divyaveer
      Abstract: Standard coagulation tests (SCTs) like prothrombin time (PT), activated partial thromboplastin time and international normalized ratio (INR) are determined by liver-synthesized coagulation factors. Despite an increased INR, patients with cirrhosis are in a ‘rebalanced’ state of haemostasis as the concomitant effect of reduced protein C, protein S and thrombomodulin is not evaluated in SCTs. The cell-based model of hemostasis indicates additional mechanisms such as systemic inflammation, sepsis and organ failures tip the delicate coagulation balance to an anticoagulant type in acute-on-chronic liver failure (ACLF).
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-05-08
      DOI: 10.1016/j.jceh.2021.05.001
  • Isolated hepatic tuberculosis: a difficult diagnosis
    • Authors: Markus Wilhelmi
      Abstract: We read with great interest the fascinating manuscript by Malewadkar et al. describing a case of isolated hepatic tuberculosis (TB) presenting with fever and chills and then developing bleeding into the abscess cavity, necessitating an emergency right liver resection.1
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-05-05
      DOI: 10.1016/j.jceh.2021.04.015
  • Liver transplantation during the times of COVID-19 – viruses,
           vaccines and beyond
    • Authors: Adithya M. Pathanki; Darius F. Mirza
      Abstract: The ongoing COVID-19 pandemic has had unprecedented effects on the care of patients with liver disease due to a loss of resources, personnel and donors. It led to a glut of communication, in a massive global effort of coordinated scientific collaboration. This was initially led by experts from China and Italy which saw the first peaks in COVID-19 and has since been supplemented by various professional bodies on liver disease and liver transplant (LT) across the world1–3. Within the field of liver transplantation, a multitude of guidelines have been published with respect to various aspects, the commonest topic being the impact of COVID infection in LT recipients2.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-05-04
      DOI: 10.1016/j.jceh.2021.04.014
  • Kupffer cell hyaline globule in children with autoimmune hepatitis
    • Authors: Mohammed A. Khedr; Nermin M. Adawy, Tahany A. Salim, Menan E. Salem, Ramy Mohamed Ghazy, Ahmed S. Elharoun, Mervat M. Sultan, Nermine A. Ehsan
      Abstract: Hyaline globules (HGs) in the cytoplasm of Kupffer cells (KCs) have been appraised for being a typical feature of autoimmune hepatitis (AIH). This study aimed to see how useful KCHGs are in diagnosing AIH versus other causes of pediatric chronic liver diseases (PCLDs).
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-05-03
      DOI: 10.1016/j.jceh.2021.04.013
  • Hepatogenous diabetes: A Primer
    • Authors: Preetam Nath; Anil C. Anand
      Abstract: As liver is one of the primary organs involved in glucose homeostasis, it is not surprising that patients with liver dysfunction in chronic liver disease usually develop impaired glucose tolerance and subsequently overt diabetes later in their natural course. The diabetes which develops after the onset of cirrhosis of liver is usually referred to as hepatogenous diabetes(HD). It is an underrecognized and a hallmark endocrinological event in chronic liver disease. Hepatogenous diabetes is associated with a higher risk of developing hepatic decompensations such as ascites, variceal bleeding, hepatic encephalopathy, renal dysfunction, refractory ascites and hepatocellular carcinoma along with reduced survival rates than normoglycemic patients with cirrhosis of liver.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-30
      DOI: 10.1016/j.jceh.2021.04.012
  • Rodenticide (yellow phosphorus poison) induced hepatotoxicity in India:
           Constraints during management
    • Authors: Chundamannil Eapen Eapen; Jayanthi Venkataraman
      Abstract: Acute hepatic dysfunction is categorized as acute liver injury (ALI) i.e. presence of coagulopathy, with no encephalopathy and acute liver failure (ALF) i.e., presence of encephalopathy and coagulopathy1. Higher degree of coagulopathy is loosely termed as severe ALI; however, this is not well defined. Patients with severe ALI or ALF need early recognition as seriously ill patients, requiring urgent specialized care.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-29
      DOI: 10.1016/j.jceh.2021.04.011
  • A new variant of an old itch: Novel missense variant in ABCB4 presenting
           with intractable pruritus
    • Authors: Sahana Shankar; Apurva Pande, Thenral S. Geetha, Karthik Raichurkar, Malikarjun Sakpal, Rajiv Lochan, Sonal Asthana
      Abstract: We report a novel homozygous missense variant in ABCB4 gene in a Yemeni child born to consanguineous parents, with a significant family history of liver disease related deaths, resulting in a progressive familial intrahepatic cholestasis (PFIC) type 3 phenotype requiring liver transplantation for intractable pruritus.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-29
      DOI: 10.1016/j.jceh.2021.04.010
  • Do natural porto-systemic shunts need to be compulsorily ligated in living
           donor liver transplantation'
    • Authors: Aarathi Vijayashanker; Bhargava Ram Chikkala, Roshan Ghimire, M Rajgopal Acharya, Yuktansh Pandey, Rajesh Dey, Shahnawaz Bashir Kaloo, Shaleen Agarwal, Subhash Gupta
      Abstract: Natural portosystemic shunt ligation practices in liver transplant vary widely across transplant centres and are frequently undertaken to prevent the serious consequence of portal steal phenomenon. No concrete indications have so far been convincingly identified for their management in living donor liver transplant.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-24
      DOI: 10.1016/j.jceh.2021.04.009
  • Perivenous hepatic iron deposition in chronic liver disease: MRI
    • Authors: Uday Kumar Marri; Kumble Seetharama Madhusudhan
      Abstract: Perivenous hepatic iron deposition is preferential deposition of iron in the liver parenchyma around the hepatic veins. It is rare and is primarily seen in patients with liver cirrhosis and iron overload.1 It has been hypothesized that the decreased portal blood flow in this area in patients of chronic liver disease leads to such skewed iron deposition.2 Such a distribution is probably unique to alcoholic liver disease.1 On magnetic resonance imaging (MRI), the perivenous parenchyma of the liver shows darker signal on the longer TE (echo time) T1-weighted images due to the magnetic susceptibility effects of iron.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-20
      DOI: 10.1016/j.jceh.2021.04.008
  • Epidemiology, genotyping, mutational and phylogenetic analysis of
           Hepatitis B virus infection in north-east India
    • Authors: Premashis Kar; Bhabadev Goswami, Jagdish Mahanta, Thngam Bhimo, Anup K. Das, Manab Deka, Kyrshanlang G. Lynrah, Mool Raj Kotwal, Pradip Bhaumik, Moji Jini, Rahul Karna, Vijay K. Karra, Harpreet Kaur
      Abstract: /Objective: Hepatitis B virus (HBV) infection is a major public health problem globally. Northeast India is home to indigenous tribes with different ethnicity and high rates of drug abuse and HIV infection. The study was designed to estimate burden of HBV infection across various spectrums of liver diseases from this region. HBV genotypes and sub genotypes play a role in chronicity of disease, response to treatment and its progression. Since very limited data is available from this region, we tried to elucidate the role of HBV genotypes, HBV mutants and their phylogenetic analysis.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-18
      DOI: 10.1016/j.jceh.2021.04.002
  • Liver injury associated with drugs and complementary and alternative
           medicines in India
    • Authors: Einar S. Björnsson
      Abstract: Idiosyncratic drug-induced liver injury (DILI) is an important differential diagnosis in patients with abnormal liver tests (1). The presentation is acute in the vast majority of cases and the diagnosis is challenging. DILI is the most common cause of acute liver failure in the US (2) and Europe (3) but in India viral hepatitis is the most common cause followed by liver injury due to anti-tuberculosis therapy (4). During the last two decades interest in the study of DILI has increased considerably.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-13
      DOI: 10.1016/j.jceh.2021.04.006
  • Suppression of Bile Acid Synthesis in a Preterm Infant Receiving Prolonged
           Parenteral Nutrition
    • Authors: Naureen Memon; Chris W. Lee, Aimee Herdt, Barry I. Weinberger, Thomas Hegyi, Mary O. Carayannopoulos, Lauren M. Aleksunes, Grace L. Guo, Ian J. Griffin
      Abstract: Bile acid metabolism is altered in neonates on parenteral nutrition (PN) predisposing them to parenteral nutrition-associated liver disease. Cholesterol 7α-hydroxylase (CYP7A1), the rate limiting enzyme in the bile acid synthesis pathway, is repressed by fibroblast growth factor 19 (FGF19) and phytosterols (PS). We describe a case of a preterm infant who developed necrotizing enterocolitis (NEC) and received exclusive PN for over 2 months. Our objective was to serially assess CYP7A1 activity and plasma FGF19 and PS concentrations in this case infant compared to 5 healthy preterm infants.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-12
      DOI: 10.1016/j.jceh.2021.04.007
  • Liver involvement in tuberculosis: a polymorphic disease with protean
    • Authors: Gebrehiwet Semere
      Abstract: We read with great interest the fascinating manuscript by Elhence et al. describing a case of granulomatous tubercular hepatitis associated with hemophagocytic lymphohistiocytosis (HLH), successfully managed with a combination of immunosuppressants and antitubercular therapy.1 They also present a systematic review of tuberculosis-associated HLH (TB-HLH) literature as a rare clinical entity. Although we find this case very interesting and of clinical relevance, we would like to add a comment that we consider relevant on the hepatic involvement of tuberculosis (TB).
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-12
      DOI: 10.1016/j.jceh.2021.03.013
  • Poor outcomes after recidivism in living donor liver transplantation for
           alcohol-related liver disease
    • Authors: Narendra S. Choudhary; Neeraj Saraf, Swapnil Dhampalwar, Sanjiv Saigal, Dheeraj Gautam, Amit Rastogi, Prashant Bhangui, Thiagrajan Srinivasan, Vipul Rastogi, Saurabh Mehrotra, Arvinder S. Soin
      Abstract: Recidivism in patients with liver transplant for alcohol-related liver disease (ALD) is shown to be associated with poor survival in some studies.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-09
      DOI: 10.1016/j.jceh.2021.04.005
  • Profile of hepatobiliary dysfunction in hematopoietic stem cell transplant
           recipients: autoimmune diseases also contribute
    • Authors: Linda Beenet
      Abstract: I read with great interest the very interesting study by Manrai et al investigating hepatobiliary dysfunction among Indian patients underwent Hematopoietic stem cell transplantation (HSCT).1
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-09
      DOI: 10.1016/j.jceh.2021.03.017
  • Suppurative Pylephlebitis With Portal Vein Abscess Mimicking Portal Vein
           Thrombosis: A Report of Two Cases
    • Authors: V.S. Shyam; Shaleen Rana, B.R. Vinay Kumar, Ashok Choudhury, Amar Mukund
      Abstract: Suppurative pylephlebitis, that is, infected thrombosis of the portal vein and its branches is a rare condition with a high incidence of mortality and is often difficult to diagnose. We report two cases of suppurative pylephlebitis secondary to acute pancreatitis wherein the whole of the portal vein and its branches were transformed into an abscess cavity. The diagnosis was made after pus was seen coming out while the patient was taken up for portal vein thrombolysis. The pus was drained and the cavity was completely evacuated leading to recovery from this infection.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-08
      DOI: 10.1016/j.jceh.2021.03.014
  • Safety and efficacy of saroglitazar in non-alcoholic fatty liver patients
    • Authors: Rajesh NA; Drishya L, Murali Mohan Raju Ambati, Athi Narayanan L, Maria Alex, Kiran Kumar R, Justin Jacob Abraham, Vijayakumar TM
      Abstract: Saroglitazar - a unique dual peroxisome proliferator activated receptor (PPAR) agonist was approved marketing authorization in India in 2013 for diabetic dyslipidemia. Post marketing studies have additionally shown improvement in Liver parameters in Diabetic Dyslipidemia patients with Non-alcoholic fatty liver disease (NAFLD) who received Saroglitazaar.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-08
      DOI: 10.1016/j.jceh.2021.03.012
  • Hepatic Tuberculosis: A wolf in sheep’s clothing
    • Authors: Anshuman Elhence; Shalimar
      Abstract: We thank Dr Semere for the keen interest in our article on granulomatous tubercular hepatitis presenting as hemophagocytic lymphohistiocytosis (HLH).1 We agree that isolated hepatic tuberculosis is a rare manifestation of extrapulmonary tuberculosis but the presence of isolated hepatic tuberculosis without evidence of tuberculosis elsewhere has been described in the literature.2 Also, hepatic tuberculosis is not always innocuous or insidious, as suggested. Alvarez had classified hepatic involvement in tuberculosis based on its clinical features into 1) miliary form: characterised by disseminated tuberculosis and no symptoms of liver involvement, 2) granulomatous tubercular hepatitis: characterised by unexplained fever, jaundice and mildly elevated liver enzymes and presence of caseating granulomas in the liver and 3) localised hepatic tuberculosis: characterised by localised involvement of the liver in the form of a nodule, pseudotumor or abscess, with or without the involvement of the biliary system.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-07
      DOI: 10.1016/j.jceh.2021.04.001
  • Hepatic angiosarcoma – Uncommon presentation of a rare tumor and its
           management by interventional radiology
    • Authors: Gaurav Chayan Das; Sreedhara B. Chaluvashetty, Shruti Gupta, Arka De
      Abstract: Hepatic angiosarcoma is an uncommon primary malignancy of liver. It carries a poor prognosis due to very aggressive nature of the tumor. Clinical presentation of hepatic angiosarcoma is variable, most common being hepatomegaly or abdominal mass. Here we report a case of primary hepatic angiosarcoma presented with spontaneous rupture and hemoperitoneum which was managed successfully by transarterial embolization.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-07
      DOI: 10.1016/j.jceh.2021.03.016
  • European Working Group on Sarcopenia in Older People (EWGSOP2) criteria
           with population-based skeletal muscle index best predicts mortality in
           Asians with cirrhosis
    • Authors: Abhinav Anand; Srikant Mohta, Samagra Agarwal, Sanchit Sharma, Srikanth Gopi, Deepak Gunjan, Kumble Seetharama Madhusudhan, Namrata Singh, Anoop Saraya
      Abstract: Multiple definitions of sarcopenia exist and the acceptable criterion which best predicts outcome is lacking. We estimated the prevalence of sarcopenia based on four criteria and assessed their utility in predicting mortality in cirrhotics.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-07
      DOI: 10.1016/j.jceh.2021.03.015
  • Acute Variceal Bleed in Cirrhosis is Associated With Reversible Changes in
           Tight Junction Protein Expression in the Intestine: A Proof-of-Concept
    • Authors: Kanav Kaushal; Vipin Gupta, Pooja Goswami, Samagra Agarwal, Sanchit Sharma, Prasenjit Das, Rajni Yadav, Abhinav Anand, Ujjwal Sonika, Deepak Gunjan, Anoop Saraya
      Abstract: Tight junction proteins (TJPs) play an important role in gut-barrier dysfunction in cirrhosis and its complications such as acute variceal bleed (AVB). However, the dynamics of TJPs expression after AVB, its relation to bacterial translocation, and impact on clinical outcome is largely unknown.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-03
      DOI: 10.1016/j.jceh.2021.03.009
  • Surgical Procedures in Patients Awaiting Liver Transplantation:
           Complications and Impact on the Liver Function
    • Authors: Imke Honerkamp; Lisa Sandmann, Nicolas Richter, Michael P. Manns, Torsten Voigtländer, Florian W.R. Vondran, Thomas von Hahn
      Abstract: Potential indications for surgery frequently arise in patients awaiting liver transplantation. There is a risk of hepatic decompensation and death triggered by surgical trauma, but this has not been studied in detail in this unique population. We aimed to quantify the impact of surgical interventions in patients awaiting liver transplantation on hepatic function and identify risk factors for decompensation.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-02
      DOI: 10.1016/j.jceh.2021.03.011
  • Safety assessment of autologous stem cell combination therapy in patients
           with decompensated liver cirrhosis: a pilot study
    • Authors: Mithun Sharma; Pavan Kumar Pondugala, Shashidhar Jaggaihgari, Sasikala Mitnala, Vemula Venkata Krishna, Ganesh Jaishetwar, Pragati Naik, Pramod Kumar, Anand Kulkarni, Rajesh Gupta, Jagdeesh Rampal Singh, Santosh Darisetty, Anuradha Sekharan, DuvurrNageshwar Reddy, GuduruVenkat Rao, Fatima Syeda, Nitin Jagtap, Padaki Nagaraja Rao.
      Abstract: Lay summaryStem cells are cells in human body which can help an organ regenerate. Combining two types of stem cell in patients with cirrhosis is a safe procedure and this study paves the way for further clinical result oriented studies.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-04-01
      DOI: 10.1016/j.jceh.2021.03.010
  • Total Internal Biliary Diversion for Post–Liver Transplant
           PFIC-1–Related Allograft Injury
    • Authors: Naresh Shanmugam; Jagadeesh Menon, Mukul Vij, Ashwin Rammohan, Rajesh Rajalingam, Mohamed Rela
      Abstract: Steatohepatitis and diarrhea are well-known complications in children undergoing liver transplantation (LT) for progressive familial intrahepatic cholestasis (PFIC) type 1. Despite medical management with bile acid binders, the condition is progressive and can be associated with allograft loss. We report the case of a seven-year-old boy who underwent LT at the age of 2 years for PFIC type 1. Over the next five years, he developed refractory diarrhea, emaciation, worsening liver function, and steatohepatitis.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-03-30
      DOI: 10.1016/j.jceh.2021.03.008
  • Early Allograft Dysfunction After Live Donor Liver Transplantation: It's
           Time to Redefine'
    • Authors: Viniyendra Pamecha; Bramhadatta Pattnaik, Piyush K. Sinha, Nilesh S. Patil, Shridhar V. Sasturkar, Nihar Mohapatra, Guresh Kumar, Ashok Choudhury, Shiv K. Sarin
      Abstract: An ideal definition of early allograft dysfunction (EAD) after live donor liver transplantation (LDLT) remains elusive. The aim of the present study was to compare the diagnostic accuracies of existing EAD definitions, identify the predictors of early graft loss due to EAD, and formulate a new definition, estimating EAD-related mortality in LDLT recipients.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-03-30
      DOI: 10.1016/j.jceh.2021.03.007
  • Diagnosis of Primary Sclerosing Cholangitis Beyond Childhood is Associated
           with Worse Outcomes
    • Authors: Stefani Tica; Saad Alghamdi, Christopher Tait, Bonsa Nemera, Yumirle Turmelle, Jaquelyn Fleckenstein, Janis Stoll, Sakil Kulkarni
      Abstract: The elucidation of differences between adult and pediatric-onset primary sclerosing cholangitis (PSC) may inform clinical decision making, and whether results of adult PSC clinical trials can be extrapolated to pediatric subjects.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-03-25
      DOI: 10.1016/j.jceh.2021.03.006
  • Prevalence, Predictors, and Outcomes of Esophageal Candidiasis in
           Cirrhosis: An Observational Study With Systematic Review and Meta-Analysis
    • Authors: Nipun Verma; Saurabh Mishra, Shreya Singh, Arka De, Madhumita Premkumar, Sunil Taneja, Ajay Duseja, Virendra Singh
      Abstract: Gastrointestinal candidiasis is often neglected and potentially serious infection in cirrhosis patients. Therefore, we evaluated the prevalence, risk factors, and outcomes of esophageal candidiasis (EC) in cirrhotics and did a systematic review to summarize EC's available evidence in cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-03-21
      DOI: 10.1016/j.jceh.2021.03.005
  • Endoscopic Stone Extraction followed by Laparoscopic Cholecystectomy in
           Tandem for Concomitant Cholelithiasis and Choledocholithiasis: A
           Prospective Study
    • Authors: Doraiswami Babu Vinish; Gautham Krishnamurthy, Patta Radhakrishna, Arulprakash Sarangapani, Senthil Ganesan, Jayapriya Ramas, Ragavendran Kalyanasundaram, Balakrishnan S. Ramakrishna
      Abstract: Single-session endoscopic stone extraction (ESE) and laparoscopic cholecystectomy (LC) has the best outcome in managing concomitant cholelithiasis (gallstone disease [GSD]) and choledocholithiasis (common bile duct stone [CBDS]). Traditional rendezvous technique with an intraoperative cholangiogram is associated with various technical (bowel distention, frozen Calot's triangle, limitation of intraoperative cholangiogram and so on) and logistical difficulties (lack of trained personnel and equipment for ESE in the operating room).
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-03-19
      DOI: 10.1016/j.jceh.2021.03.004
  • Versatility of Anabolic Androgenic Steroids (AAS) induced Hepatotoxicity
    • Authors: V. Patil; D. Jothimani, K. Harika, A.R. Hakeem, D. Sachan, M. Vij, M. Rela
      Abstract: The modified derivatives of testosterone, termed as androgenic steroids are indicated in the management of hypogonadism, visceral obesity and metabolic disorders. Anabolic androgenic steroids (AAS), however are surreptitiously used by athletes and body builders for cosmetic purpose due to its anabolic effects on muscle mass and strength. The unsurveilled use of AAS subjects these users to various side effects involving multiple systems like endocrine, genitourinary, hepatobiliary, central nervous system, musculoskeletal, psychosocial.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-03-10
      DOI: 10.1016/j.jceh.2021.03.003
  • Adipocytokines as risk factors of the development of nonalcoholic fatty
           liver disease in children
    • Authors: Paweł Małecki; Anna Mania, Joanna Tracz, Magdalena Łuczak, Katarzyna Mazur-Melewska, Magdalena Figlerowicz
      Abstract: Noninvasive diagnostics of nonalcoholic fatty liver disease (NAFLD), the most common cause of liver dysfunction in children, is based on imaging, biochemical tests, and their compilation. The study aimed to evaluate the serological biomarkers of steatosis, inflammation and liver fibrosis to assess the risk of NAFLD in children.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-03-09
      DOI: 10.1016/j.jceh.2021.03.002
  • Retrohepatic Caval Leiomyosarcoma Antesitum Resection: A Case Report and a
           Review of Literature
    • Authors: S. Aurobindo P. Das; Pardha S. Paleela, Madhan K. Kuppuswamy, Balaji Venugopal, Elankumaran Krishnan
      Abstract: Leiomyosarcoma of the inferior vena cava (IVC-LMS) is a rare mesenchymal tumor arising from the tunica media. In this report, we describe the antesitum resection without inferior vena cava (IVC) reconstruction of retrohepatic IVC-LMS. To our knowledge, this is the first report of antesitum resection for IVC-LMS from India. A 51-year-old lady presented with features of Budd-Chiari syndrome and abdominal pain. Evaluation showed the tumor arising from IVC extending from above the renal veins and upto the subdiaphragmatic IVC.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-03-09
      DOI: 10.1016/j.jceh.2021.01.002
  • Endotipsitis: An underdiagnosed complication of Transjugular Intrahepatic
           Portosystemic Shunts
    • Authors: Vettakkara Kandy Muhammed Niyas; Vishakh C. Keri, Prabhat Kumar
      Abstract: Recurrent haematemesis and ascites due to portal hypertension are treated by Transjugular Intrahepatic Portosystemic Shunt (TIPS) to decompress the portal system. Many causes can be attributed to fever in such patients, one of them being, endotipsitis. Awareness among the clinicians about the existence of such a condition needs to be enhanced to avoid underdiagnosis. Diagnosing, endotipsitis, a primary vegetative infection of the TIPS requires high index of suspicion. Here we describe one such case which presented with prolonged fever and sustained bacteraemia with history of TIPS thrombosis.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-03-04
      DOI: 10.1016/j.jceh.2021.02.009
  • Portal Cavernoma Cholangiopathy in Children: An evaluation using Magnetic
           Resonance Cholangiography and Endoscopic Ultrasound
    • Authors: Vybhav Venkatesh; Surinder Singh Rana, Anmol Bhatia, Sadhna B. Lal
      Abstract: Portal cavernoma cholangiopathy (PCC) refers to abnormalities of the extra and intrahepatic bile ducts in patients with portal cavernoma. The literature on PCC in children is very scarce. This study aimed at characterizing PCC in children with extra hepatic portal venous obstruction (EHPVO) using Endoscopic Ultrasound (EUS) and Magnetic Resonance Cholangiography/Portovenography (MRC/MRPV).
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-03-04
      DOI: 10.1016/j.jceh.2021.03.001
  • Role of Diffusion Weighted MRI in the Diagnosis and Grading of Hepatic
           Steatosis in the Patients of Non-Alcoholic Fatty Liver Disease: Comparison
           with Ultrasonography and Magnetic Resonance Spectroscopy
    • Authors: Nikhil Makhija; Naval K. Vikram, Deep N. Srivastava, Kumble S. Madhusudhan
      Abstract: /Objective: Non-alcoholic fatty liver disease (NAFLD) is becoming the most common cause of cirrhosis. Although magnetic resonance spectroscopy (MRS) is considered the gold standard, it has a few limitations. The role of diffusion weighted imaging (DWI), which is a simpler sequence, in the diagnosis and grading of fatty liver is not well studied. The aim of the study was to investigate the value of DWI in the diagnosis and grading of hepatic steatosis in patients of NAFLD.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-26
      DOI: 10.1016/j.jceh.2021.02.008
  • Universal HCV screening of baby boomers is feasible, but it is difficult
    • Authors: Paul J. Thuluvath; Joshua Trowell, Talan Zhang, Joseph Alukal, George Lowe
      Abstract: Our objective was to assess the impact of mass mailing and the inclusion of Best Practice Advisory (BPA) ‘Pop-Up’ tool in the electronic medical record (EMR) on HCV screening rates.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-25
      DOI: 10.1016/j.jceh.2021.02.007
  • Gilbert's Syndrome, Bilirubin Level and UGT1A1∗28 Genotype in Men of
           North-West Region of Russia
    • Authors: Andrei Ivanov; Elena Semenova
      Abstract: Gilbert's syndrome (GS) is a hereditary pathology that affects approximately 10% of the world's population. In most cases, GS is associated with the UGT1A1∗28 polymorphism of UGT1A1 gene coding the enzyme bilirubin uridine diphosphate glucuronosyltransferase (UGT-1A) which plays a key role in the bilirubin metabolism. The presence of an additional TA repeat in the TATA box of the UGT1A1 gene promoter (the allelic variant of 7TA, abbreviated as UGT1A1∗28) leads to a significant decrease in the enzymatic activity of UGT-1A in the liver and to decrease in glucuronidation process as a consequence.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-25
      DOI: 10.1016/j.jceh.2021.01.006
  • The Clinical Impact of Cirrhosis on the Hospital Outcomes of Patients
           Admitted With Influenza Infection: Propensity Score Matched Analysis of
           2011–2017 US Hospital Data
    • Authors: David U. Lee; Gregory H. Fan, David J. Hastie, Vibhav N. Prakasam, Elyse A. Addonizio, Ryan R. Ahern, Kristen J. Seog, Raffi Karagozian
      Abstract: Patients with cirrhosis have liver-related immune dysfunction that potentially predisposes the patients to increased influenza infection risk. Our study evaluates this cross-sectional relationship using a national registry of hospital patients.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-25
      DOI: 10.1016/j.jceh.2021.01.005
  • Learning Gains of Liver Resection and Transplantation Workshop on
           Genelyn® Embalmed Human Cadavers: Surgical Gastroenterologists’
    • Authors: Sajja Srinivasa Siva Naga Rajasekhar; Vishwakumar Dinesh Kumar, Gnanasekaran Senthil, Biju Pottakat, Raja Kalayarasan, Veeramani Raveendranath, Ram Prakash Gurram
      Abstract: In the light of increased requirement for liver transplantation procedures, it is pertinent to develop bankable human expertise in the areas of liver resection and anastomoses. The alternative simulator sources available for learning surgical skills might not always provide the realistic learning gains as provided by human cadavers, especially in terms of haptic and tactile fidelity. For the first time, we have used Genelyn® embalmed cadavers (GEC) for training the surgical gastroenterologists in liver resection and transplantation procedures and we wish to document our experience of using them to facilitate the learning of liver resection procedures.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-24
      DOI: 10.1016/j.jceh.2021.01.001
  • Nonalcoholic Fatty Liver in Lean Individuals: Clinicobiochemical
           Correlates of Histopathology in 157 Liver Biopsies from Healthy Liver
    • Authors: Narendra S. Choudhary; Neeraj Saraf, Sanjiv Saigal, Ajay Duseja, Dheeraj Gautam, Amit Rastogi, Prashant Bhangui, Srinivasan Thiagrajan, Arvinder S. Soin
      Abstract: Generally diagnosis of non-alcoholic fatty disease is made on imaging, however, mild steatosis is difficult to diagnose on imaging. Liver biopsy is the procedure of choice but is not carried out as it is an invasive procedure. We describe our experience of 157 liver biopsies in living liver donors with normal body mass index (BMI)
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-23
      DOI: 10.1016/j.jceh.2021.01.004
  • Hereditary Persistence of Alpha-Fetoprotein in Chronic Liver
           Disease-Confusing Genes!
    • Authors: Vaibhav Patil; Dinesh Jothimani, Gomathy Narasimhan, Silas Danielraj, Mohamed Rela
      Abstract: Alpha-fetoprotein (AFP) is a glycoprotein secreted by the embryonic liver and is expressed in tumours with high mitotic index such as hepatocellular carcinoma (HCC) and germ cell tumours. Detection of elevated AFP is strongly associated with underlying HCC or occasionally germ cell tumour. Modest elevation of AFP can be observed in patients with chronic viral hepatitis particularly with active replication. Very rarely, incidental detection of raised AFP in a genetically susceptible individuals has been reported in the absence of the underlying malignant process.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-22
      DOI: 10.1016/j.jceh.2020.12.008
  • A study of prevalence of occult hepatitis B virus infection, knowledge and
           preventive practices against hepatitis B virus in barbers serving the
           armed forces
    • Authors: Atul Kumar Sood; Sukant Mihir Pathak, Nitish Khandelwal
      Abstract: Hepatitis B virus (HBV) infection is a major health problem in the world. Barbers deal with frequent abrasions/lacerations due to sharp equipment making them a high-risk group. Determination of HBsAg positive status excludes most reservoirs of transmission in the population. However, Occult Hepatitis B continues to be a source of transmission. The aim of this study was to study the prevalence of occult HBV infection in barbers serving the armed forces clientele and evaluate their knowledge and preventive practices against HBV transmission.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-20
      DOI: 10.1016/j.jceh.2021.02.005
  • Cyproterone Acetate–Induced Acute Liver Failure: A Case Report and
           Review of the Literature
    • Authors: Pramod Kumar; Sujith Reddy, Anand Kulkarni, Mithun Sharma, Padaki N. Rao
      Abstract: Cyproterone acetate (CPA), a hydroxyprogesterone derivative, is used to treat advanced prostate cancer and infrequently in women for acne, breast cancer and hirsutism. Transient mild elevation in levels of liver enzymes is reported in 10–30% of patients, and acute liver failure (ALF) is uncommon. Here, we discuss the first case of CPA-induced ALF from India and the available literature.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-18
      DOI: 10.1016/j.jceh.2021.01.003
  • Type Va Duplication of Common Bile Duct (CBD) with Type IIIa Intrahepatic
           bile duct anatomy: A rare combination of Dual Biliary ductal anomaly with
           difficult to extract CBD stone
    • Authors: Pankaj Singh; Hitendra Kumar Garg, Jayant Kumar Hota, Sandeep Guleria, Sandeep Vohra, Sudeep Khanna, Anvita Singh, Nitin P. Ghonge
      Abstract: Extrahepatic duplication of common bile duct is an extremely rare anatomic variation of the biliary tract seen. It represents failure of regression of primitive duplicated biliary ductal system resulting in five different subtypes of duplicated CBD as described by Choi et al. Till date only few such cases has been reported in literatures. Associated variation in branching of intrahepatic bile ducts presenting as combined dual ductal anomaly is even rarer phenomena to be seen. We report a case of 67-year-old, chronic kidney disease patient with obstructive jaundice resulting from choledocholithiais.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-16
      DOI: 10.1016/j.jceh.2021.02.004
  • Survival and outcome in patients receiving Drug Eluting Beads
           Transarterial Chemoembolization (DEB-TACE) for large HCC (> 5cm)
    • Authors: Amar Mukund; Krishna Bhardwaj, Ashok Choudhury, Shiv Kumar Sarin
      Abstract: To study the outcome and survival of patients with large hepatocellular carcinoma (HCC) receiving drug eluting beads (DEB) transarterial chemoembolization (TACE). Additionally, tumor morphologies were correlated with the response and survival to analyze association of morphology with outcome.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-15
      DOI: 10.1016/j.jceh.2021.02.003
  • Effect of COVID-19 on Pre-existing Liver disease: What Hepatologist Should
    • Authors: Sharma Praveen; Kumar Ashish, ShriHari A. Anikhindi, Bansal Naresh, Singla Vikas, Shivam Khare, Arora Anil
      Abstract: COVID-19 is characterized by predominant respiratory and gastrointestinal symptoms. Liver enzymes derangement is seen in 15–55% of the patients. Advanced age, hypertension, diabetes, obesity, malignancy, and cardiovascular disease predispose them to severe disease and the need for hospitalization. Data on pre-existing liver disease in patients with COVID-19 is limited, and most studies had only 3–8% of these patients. Patients with metabolic dysfunction-associated fatty liver (MAFLD) had shown a 4–6 fold increase in severity of COVID-19, and its severity and mortality increased in patients with higher fibrosis scores.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-12
      DOI: 10.1016/j.jceh.2020.12.006
  • Experience with changing etiology and NON-TRANSPLANT curative treatment
           modalities for Hepatocellular carcinoma in a real-life setting – A
           retrospective descriptive analysis
    • Authors: Suneel Tohra; Ajay Duseja, Sunil Taneja, Naveen Kalra, Ujjwal Gorsi, Arunanshu Behera, Lileswar Kaman, Divya Dahiya, Srimanta Sahu, Balkrishan Sharma, Virendra Singh, Radha K. Dhiman, Yogesh Chawla
      Abstract: Hepatocellular carcinoma (HCC) has variable etiological risk factors. Radiofrequency ablation (RFA) and surgical resection (SR) are frequently used as curative treatment options. In the present study we assessed the etiological factors and efficacy of RFA and SR in patients with unifocal HCC in a real-life setting.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-10
      DOI: 10.1016/j.jceh.2021.02.002
  • Human Fascioliasis: Report of Two Cases from Kashmir Valley
    • Authors: Ghulam N. Yattoo; Gulzar A. Dar, Kowsar Jan, Jaswinder S. Sodhi, Zubaida Rasool, Saurabh Kaushik, Suresh Gorka
      Abstract: Although few case reports of human fascioliasis have been reported from different parts of India, there is no case reported from the Kashmir valley to date. Herein we report two cases of human fascioliasis. Both patients presented with fever, marked eosinophilia, and liver lesions on imaging. Hepatobiliary imaging showed vague features like mild biliary dilatation and liver lesions representing burrows. A liver biopsy in one of the patients revealed eosinophilic granuloma. Both patients were diagnosed definitively with endoscopic retrograde cholangiopancreatography (ERCP) by demonstrating live adult fasciola worms.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-09
      DOI: 10.1016/j.jceh.2020.12.010
  • Dyslipidemia Increases the Risk of Severe COVID-19: A Systematic Review,
           Meta-analysis, and Meta-regression
    • Authors: Indriwanto Sakidjan Atmosudigdo; Raymond Pranata, Michael Anthonius Lim, Joshua Henrina, Emir Yonas, Rachel Vania, Basuni Radi
      Abstract: This systematic review and meta-analysis aimed to evaluate whether dyslipidemia affects the mortality and severity of COVID-19, we also aimed to evaluate whether other comorbidities influence the association.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-07
      DOI: 10.1016/j.jceh.2021.01.007
  • Admission Serum Urea is a Better Predictor of Mortality than Creatinine in
           Patients With Acute-On-Chronic Liver Failure and Acute Kidney Injury
    • Authors: Chitta R. Khatua; Saroj K. Sahu, Dinesh Meher, Gautam Nath, Archisman Mohapatra, Bhaskar Thakur, Shivaram P. Singh
      Abstract: The occurrence of acute kidney injury (AKI) in acute-on-chronic liver failure (ACLF) negatively impacts the survival of patients. There are scant data on the impact of serum urea on outcomes in these patients. We performed this study to evaluate the relationship between admission serum urea and the survival in patients with ACLF and AKI.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-04
      DOI: 10.1016/j.jceh.2020.12.005
  • Midodrine Improves the Tolerability of Diuretics in Patients with
           Acute-on-Chronic Liver Failure—A Pilot Study
    • Authors: Anand V. Kulkarni; Pramod Kumar, Mithun Sharma, Sowmya T. Ravikumar, Harshvardhan Tevethia, Samragni Vasireddy, Rajesh Gupta, Duvvuru N. Reddy, Nagaraja P. Rao
      Abstract: Acute-on-chronic liver failure (ACLF) is a syndrome of acute portal hypertension with high short-term mortality. ACLF patients have low mean arterial pressure (MAP), systemic vascular resistance, and high cardiac output. This, in turn, leads to an increased incidence of ascites, acute kidney injury, and hyponatremia. We evaluated the role of the early addition of midodrine, which has not been analyzed to date.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-04
      DOI: 10.1016/j.jceh.2020.12.002
  • Primary Versus Secondary NAFLD: Perspective on Advanced Fibrosis
    • Authors: Divya Shetty; Anjali Amarapurkar, Akash Shukla
      Abstract: The presence of macrovesicular steatosis on liver biopsy is the commonest histopathological finding. Nonalcoholic fatty liver disease (NAFLD) is the presence of ≥5% macrovesicular steatosis without significant alcohol use. It is subdivided into primary and secondary NAFLD; information on their differences is limited.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-01
      DOI: 10.1016/j.jceh.2020.12.009
  • A Long-Term Prospective Study of Quality of Life, Abdominal Symptoms, and
    • Authors: Piyush K. Sinha; Nihar Mohapatra, Kishore GS. Bharathy, Guresh Kumar, Viniyendra Pamecha
      Abstract: Comprehensive assessment of quality of life of live liver donors is required for adequate donor outcome reporting, but there is a lack of prospective data. Assessment of all aspects of liver donation over a long period is a necessity to have complete understanding of the donation process.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-01-28
      DOI: 10.1016/j.jceh.2020.11.005
  • If Hoofbeats are not From Horses, It Could be Zebras!! Isolated
           Hyper-alkaline Phosphatasemia
    • Authors: Mahak Chauhan; David H. Alpers, James P. Hamilton, Paul J. Thuluvath
      Abstract: Alkaline phosphatase (AP) is a membrane bound enzyme and when it is elevated in blood, it is mostly due to either hepatobiliary or bone diseases. We report isolated intestinal hyperphosphatasemia (IAP) in two sisters. Both sisters presented with identical trends of isolated AP elevation. Both underwent extensive workup for liver diseases including cholangiograms, and none was identified. Subsequent isoenzyme electrophoresis showed that 45%–56% of the elevated AP was due to IAP. This elevation of the intestinal AP is consistent with a rare hereditary biochemical abnormality, benign familial intestinal hyperphosphatemia.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-01-05
      DOI: 10.1016/j.jceh.2020.12.001
  • Severe Acute Respiratory Syndrome Coronavirus 2–related
           Acute-on-chronic Liver Failure
    • Authors: Pramod Kumar; Mithun Sharma, Syeda F. Sulthana, Anand Kulkarni, Padaki N. Rao, Duvvuru N. Reddy
      First page: 404
      Abstract: Acute-on-chronic liver failure (ACLF) is a condition associated with hepatic and extrahepatic organ failure with high short-term mortality.2 The data regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–related ACLF (S-ACLF) are scarce.2–8 Whether patients with cirrhosis are at a high risk of developing ACLF after coronavirus disease 2019 (COVID-19) needs further elucidation. Here, we report our observation of patients with COVID-19 and ACLF (as per European Association for the Study of the Liver-Chronic Liver Failure (EASL-CLIF) definition).
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-01-29
      DOI: 10.1016/j.jceh.2020.12.007
  • Severe jaundice in a COVID-19 patient-virus or drug'
    • Authors: Dinesh Jothimani; Mukul Vij, Uday Sanglodkar, Vaibhav Patil, Deepti Sachan, Gomathy Narasimhan, Ilankumaran Kaliamoorthy, Mohamed Rela
      First page: 407
      Abstract: Dinesh jothimani, uday sanglodkar and vaibhav patil prepared the manuscript. Mukul Vij prepared the histopathology findings. Deepti sachan, Gomathy narasimhan and Ilankumuran kaliamoorthy did the proof reading of the manuscript. Mohamed Rela did the critical review and gave permission for publication.
      Citation: Journal of Clinical and Experimental Hepatology (2021)
      PubDate: 2021-02-25
      DOI: 10.1016/j.jceh.2021.02.006
  • Quantification of Liver Fat by MRI-PDFF Imaging in Patients with Suspected
           Non-alcoholic Fatty Liver Disease and Its Correlation with Metabolic
           Syndrome, Liver Function Test and Ultrasonography
    • Authors: Gajanan A. Rodge; Mahesh K. Goenka, Usha Goenka, Shivaraj Afzalpurkar, Bhavik B. Shah
      Abstract: Magnetic resonance imaging (MRI)–estimated proton density fat fraction (PDFF) has emerged to be a promising tool in quantification of liver fat. Aim of this study was to quantify liver fat using MRI-PDFF in patients with suspected non-alcoholic fatty liver disease (NAFLD) and to correlate it with the presence of metabolic syndrome (MetS), ultrasonography (USG) and liver function test (LFT).
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-12-29
      DOI: 10.1016/j.jceh.2020.11.004
  • Erratum to “Combined Balloon-, Plug- and Coil-assisted Retrograde
           Transvenous Obliteration of Multiple Portosystemic Shunts to Treat
           Recurrent Hepatic Encephalopathy: A Case Report” [J Clin Exp Hepatol 10
           (2020) 402–406]
    • Authors: Karan M. Anandpara; Amar Mukund, Shiv K. Sarin
      Abstract: The publisher regrets that the Declaration of Competing Interest statement was not included in published version of this article that appeared in volume 10 issue 4 of “Journal of Clinical and Experimental Hepatology”. Hence, the author of this article was contacted after publication to request a Declaration of Interest statement.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-12-22
      DOI: 10.1016/j.jceh.2020.12.004
  • Erratum to “Difficult to Treat Recurrent Pyogenic Cholangitis with
           Portal Pylephlebitis in the Setting of Idiopathic CD4+ Lymphocytopaenia”
           [J Clin Exp Hepatol 9 (2019) 749–752]
    • Authors: Madhumita Premkumar; Devaraja Rangegowda, Anand Kulkarni, Tanmay Vyas, Shivani Dudha, Rakhi Maiwall
      Abstract: The publisher regrets that the Declaration of Competing Interest statement was not included in the published version of this article that appeared in volume 9 issue 6 of “Journal of Clinical and Experimental Hepatology”. The appropriate Declaration of Competing Interest statement, provided by the author, is included as follows:
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-12-22
      DOI: 10.1016/j.jceh.2020.12.003
  • Intrahepatic De Novo Tumors in Liver Recipients are Highly Associated With
           Recurrent Viral Hepatitis
    • Authors: Michael J. Pflüger; Max M. Maurer, Karl H. Hillebrandt, Andreas Andreou, Dominik Geisel, Moritz Schmelzle, Johann Pratschke, Dennis Eurich
      Abstract: Long-term survival of liver transplant recipients is endangered by tumorigenesis at different sites. Little is known about primary de novo tumors developing in the graft.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-12-17
      DOI: 10.1016/j.jceh.2020.11.003
  • Outcomes of Portal Pressure-Guided Therapy in Decompensated Cirrhosis With
           Index Variceal Bleed in Asian Cohort
    • Authors: Sanchit Sharma; Samagra Agarwal, Deepak Gunjan, Kanav Kaushal, Abhinav Anand, Srikant Gopi, Srikant Mohta, Anoop Saraya
      Abstract: Hemodynamic response to pharmacotherapy improves survival in patients with cirrhosis post variceal bleeding, but long-term outcomes remain unexplored especially in this part of the world. We aimed to study the long-term impact of portal pressure reduction on liver-related outcomes after index variceal bleed.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-12-07
      DOI: 10.1016/j.jceh.2020.11.001
  • Undiagnosed Hepatic Tuberculosis Presenting With Intraabdominal Rupture
           and Hemoperitoneum, Requiring Urgent Hepatic Resection
    • Authors: Shitesh Malewadkar; Vivek Shetty, Soumil Vyas, Nilesh Doctor
      Abstract: Tuberculosis (TB) affecting the liver is unusual, and isolated liver TB presenting as a liver abscess more so, even in countries where the disease is endemic. As clinical symptoms and imaging are not typical, a high index of suspicion is necessary for diagnosis. We present here a lady who was admitted with fever and chills. Ultrasound imaging showed a liver abscess. She developed bleeding into the abscess cavity, necessitating an emergency right liver resection. Final histology confirmed mycobacterial granulomatous infection of the liver.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-12-03
      DOI: 10.1016/j.jceh.2020.09.004
  • Recurrent Pyroglutamic Acidosis in the Context of Undiagnosed Liver
           Cirrhosis—A Case Report
    • Authors: Bradley J.W. Allen; Ahmed A. Abu Shanab, Mark R. Anderson, Edward N. Fogden
      Abstract: Metabolic associated fatty liver disease, previously known as nonalcoholic fatty liver disease, is the most common cause of chronic liver disease across all ethnic groups; however, it remains enormously underestimated.1,2 Sepsis, hepatotoxic medications and malnutrition in the acute settings on top of unknown cirrhosis can lead to decompensation and various metabolic complications. Pyroglutamic acidosis is a rarely recognised cause for unexplained high anion gap metabolic acidosis that is felt to be frequently underdiagnosed.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-11-23
  • Extrahepatic Malignancies and Liver Transplantation: Current Status
    • Authors: Narendra S. Choudhary; Sanjiv Saigal, Neeraj Saraf, Arvinder S. Soin
      Abstract: Recipients of liver transplantation (LT) remain at higher risk (adjusted for other risk factors) of de novo malignancies (DNMs). The higher risk can be attributed to the effect of immunosuppression and patient-related risk factors (age, tobacco, alcohol, etiology of liver disease). DNMs are an important cause of late mortality in liver transplant recipients. The pattern (type) of posttransplant malignancies reflects pattern in local population. The common types include skin cancers, solid organ malignancies, and post-transplant lymphoproliferative disorders.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-11-20
  • Prevalence of and Factors Associated with Sleep-Wake Abnormalities in
           Patients with Cirrhosis
    • Authors: Manoj Kumar; Sumeet Kainth, Sachin Kumar, Ankit Bhardwaj, Hemant KumarAggarwal, Rakhi Maiwall, Kapil D. Jamwal, Saggere M. Shasthry, Ankur Jindal, Ashok Choudhary, Lovkesh Anand, Ravinder M. Dhamija, Guresh Chibbar, Barjesh Chander Sharma, Shiv K. Sarin
      Abstract: Sleep-wake abnormalities [poor nighttime sleep and excessive daytime sleepiness (EDS)] are common in patients with cirrhosis. The aim of this study was to assess the prevalence of sleep-wake abnormalities and clinical factors associated with these abnormalities in a group of patients with cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-11-20
  • Screening of Family Members of Nonalcoholic Fatty Liver Disease Patients
           can Detect Undiagnosed Nonalcoholic Fatty Liver Disease Among Them: Is
           There a Genetic Link'
    • Authors: Shubham Jain; Ravi Thanage, Falguni Panchal, Pravin M. Rathi, Renuka Munshi, Suhas S. Udgirkar, Qais Q. Contractor, Sanjay J. Chandnani, Nair P. Sujit, Partha Debnath, Anupam Singh
      Abstract: Nonalcoholic fatty liver disease (NAFLD) has multifactorial origin. Genetic and environmental factors lead to the biology of this complex disorder. In this study, we screened parents of cases with NAFLD and compared them with parents of cases without NAFLD to see its familial aggregation and the role of patatin-like phospholipase domain containing 3 (PNPLA3).
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-11-16
  • Acute Liver Failure Secondary to Yellow Phosphorus Rodenticide Poisoning:
           Outcomes at a Center With Dedicated Liver Intensive Care and Transplant
    • Authors: Ravi Mohanka; Prashantha Rao, Mitul Shah, Amit Gupte, Vinayak Nikam, Mihir Vohra, Ruhi Kohli, Anurag Shrimal, Ankush Golhar, Ameya Panchwagh, Saurabh Kamath, Akash Shukla, Priyesh Patel, Somnath Chattopadhyay, Gaurav Chaubal, Yasmin Shaikh, Vidhi Dedhia, Shivali S. Sarmalkar, Ravikiran Maghade, Kavita Shinde, Priyanka Bhilare, Rohini Nalawade, Jacob As, Samir Shah
      Abstract: Accidental or suicidal poisoning with yellow phosphorus or metal phosphides (YPMP) such as aluminum (AlP) zinc phosphide (Zn3P2) commonly causes acute liver failure (ALF) and cardiotoxicity. These are used as household, agricultural, and industrial rodenticides and in production of ammunitions, firecrackers, and fertilizers. In absence of a clinically available laboratory test for diagnosis or toxin measurement or an antidote, managing their poisoning is challenging even at a tertiary-care center with a dedicated liver intensive care unit (LICU) and liver transplant facility.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-11-03
      DOI: 10.1016/j.jceh.2020.09.010
  • Restructuring Living-Donor Liver Transplantation at a High-Volume Center
           During the COVID-19 Pandemic
    • Authors: Arvinder S. Soin; Narendra S. Choudhary, Sanjay K. Yadav, Sanjiv Saigal, Neeraj Saraf, Amit Rastogi, Prashant Bhangui, Thiagarajan Srinivasan, Neelam Mohan, Sujeet K. Saha, Ankur Gupta, Rohan J. Chaudhary, Kamal Yadav, Swapnil Dhampalwar, Deepak Govil, Nikunj Gupta, Vijay Vohra
      Abstract: Coronavirus disease 2019 (COVID-19) pandemic has led to deferral of elective transplants and proactive pretransplant testing of the donor/recipient. The impact of these on living-donor liver transplantation (LDLT) activity and outcome is not known. We performed LDLT only for sick patients or patients with advanced hepatocellular carcinoma in this period, with special COVID protocols.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-10-29
      DOI: 10.1016/j.jceh.2020.09.009
  • Liver Transplantation Society of India Guidelines for the Management of
           Acute Liver Injury Secondary to Yellow Phosphorus–Containing Rodenticide
           Poisoning Using the Modified Delphi Technique of Consensus Development
    • Authors: Mettu S. Reddy; Akila Rajakumar, Johns S. Mathew, L. Venkatakrishnan, Dinesh Jothimani, S. Sudhindran, Mathew Jacob, Krishnasamy Narayanasamy, Radhika Venugopal, Ravi Mohanka, Ilankumaran Kaliamoorthy, Joy Varghese, Charles Panackel, Zubair Mohamed, Mukul Vij, Deepti Sachan, V.V. Pillay, Sanjiv Saigal, Radhakrishna Dhiman, Arvinder S. Soin, Subhash Gupta, Julia Wendon, Mohamed Rela, Shiv K. Sarin
      Abstract: Acute liver failure caused by the ingestion of yellow phosphorus–containing rodenticide has been increasing in incidence over the last decade and is a common indication for emergency liver transplantation in Southern and Western India and other countries. Clear guidelines for its management are necessary, given its unpredictable course, potential for rapid deterioration and variation in clinical practice.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-10-28
      DOI: 10.1016/j.jceh.2020.09.011
  • Late-Onset Peripheral T-Cell Lymphoma Not Otherwise Specified in a Liver
           Transplant Recipient: A Rare Subtype of Posttransplant Lymphoproliferative
    • Authors: Jagadeesh Menon; Mukul Vij, Abdul R. Hakeem, Kakumudi Rajagopal Gopi, Asma Bibi, Naresh Shanmugam, Mettu S. Reddy, Mohamed Rela
      Abstract: Posttransplant lymphoproliferative disorder (PTLD) is a rare complication seen in the period after liver transplant. The commonest subtype is B-cell PTLD which is usually associated with Epstein-Barr virus (EBV) infection. T-cell PTLD is rare and the association with EBV is again rarer.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-10-23
      DOI: 10.1016/j.jceh.2020.09.002
  • The Use of a 3D Printing Model in Planning a Donor Hepatectomy for Living
           Donor Liver Transplantation: First in India
    • Authors: Karthik K. Raichurkar; Rajiv Lochan, Mathew Jacob, Sonal Asthana
      Abstract: Three-dimensional (3D) anatomical relationships between the hepatic veins and portal structures can serve as a guide to plan resections in donor hepatectomy during living donor liver transplantation. We present the first case report from India on the use of a 3D printed liver model, as an assist to living donor liver transplantation.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-10-13
      DOI: 10.1016/j.jceh.2020.08.006
  • The Indian Network of Drug-Induced Liver Injury: Etiology, Clinical
           Features, Outcome and Prognostic Markers in 1288 Patients
    • Authors: Harshad Devarbhavi; Tarun Joseph, Nanjegowda Sunil Kumar, Chetan Rathi, Varghese Thomas, Shivaram Prasad Singh, Prabha Sawant, Ashish Goel, Chundamannil E. Eapen, Prakash Rai, Anil Arora, Venkatakrishnan Leelakrishnan, Gayathri Gopalakrishnan, Vishnu Vardhan Reddy, Rajvir Singh, Bhabadev Goswami, Jayanthi Venkataraman, Girisha Balaraju, Mallikarjun Patil, Rakesh Patel, Sunil Taneja, Abraham Koshy, Padaki Nagaraja Rao, Shiv Kumar Sarin, Pravin Rathi, Radhakrishna Dhiman, Ajay K. Duseja, Joy Vargese, Ajay Kumar Jain, Manav Wadhawan, Piyush Ranjan, Dheeraj Karanth, Panchapakesan Ganesh, Sandeep Nijhawan, Gopal Krishna Dhali, Channagiri K. Adarsh, Ajay Jhaveri, Aabha Nagral, Prasanna Rao, Shalimar
      First page: 288
      Abstract: Etiology of and outcomes following idiosyncratic drug-induced liver injury (DILI) vary geographically. We conducted a prospective study of DILI in India, from 2013 to 2018 and summarize the causes, clinical features, outcomes and predictors of mortality.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-12-15
      DOI: 10.1016/j.jceh.2020.11.002
  • Role of N-acetyl Cysteine in Post-transarterial Chemoembolization
           Transaminitis in Hepatocellular Carcinoma: A Single-center Experience
    • Authors: Chandan K. Kedarisetty; Sipra Bal, Subhashree Parida, Mayank Jain, Ajeet Bhadoria, Joy Varghese, Jayanthi Venkataraman
      First page: 299
      Abstract: Transarterial chemoembolization (TACE) is the most common locoregional therapy for hepatocellular carcinoma (HCC). Postembolization syndrome is not an uncommon complication. At present, there is no specific treatment for management of this complication. We aimed to study the role of N-acetyl cysteine (NAC), an antioxidant, in management of this complication.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-11-18
  • Percutaneous Cryoablation of Liver Tumors: Initial Experience from a
           Tertiary Care Center in India
    • Authors: Naveen Kalra; Pankaj Gupta, Tejeshwar Jugpal, Shailendra S. Naik, Ujjwal Gorsi, Sreedhara B. Chaluvashetty, Harish Bhujade, Ajay Duseja, Virendra Singh, Radha K. Dhiman, Manavjit S. Sandhu
      First page: 305
      Abstract: Percutaneous ablation is an important part of management strategy for liver tumors. While radiofrequency ablation and microwave ablation are the most widely used ablative techniques, cryoablation (CA) has several technical advantages but has been underused till recently. In this study, we report the initial experience with percutaneous CA of liver tumors.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-11-13
  • Management Practices and Predictors of Outcome of Liver Abscess in Adults:
           A Series of 1630 Patients from a Liver Unit
    • Authors: Ankur Jindal; Apurva Pandey, Manoj K. Sharma, Amar Mukund, Rajan Vijayaraghavan, Vinod Arora, Saggere M. Shasthry, Ashok Choudhary, Shiv K. Sarin
      First page: 312
      Abstract: The management practices of liver abscess (LA) have evolved over time. The precise diagnosis of etiology and complications is pivotal for appropriate management.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-11-17
  • Revisiting the Surgical Management of Giant Hepatic Hemangiomas:
           Enucleation Versus Anatomical Resection'
    • Authors: Muthukumarassamy Rajakannu; Gerard Pascal, Denis Castaing, Eric Vibert, Christian Ducerf, Jean-Yves Mabrut, Jacques Baulieux, René Adam
      First page: 321
      Abstract: Resection is rarely indicated in giant hepatic hemangiomas (HHs) that are symptomatic. Enucleation (EN), compared with anatomical resection (AR), is considered the better technique to resect them as EN has been reported to have lower morbidity while conserving the normal liver tissue. But no study has yet clearly established the superiority of EN over AR. In addition, the independent predictors of postoperative morbidity have not been established.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-11-05
      DOI: 10.1016/j.jceh.2020.09.008
  • Outcome of Conservative Therapy in Coronavirus disease-2019 Patients
           Presenting With Gastrointestinal Bleeding
    • Authors: Shalimar; Manas Vaishnav, Anshuman Elhence, Ramesh Kumar, Srikant Mohta, Chandan Palle, Peeyush Kumar, Mukesh Ranjan, Tanmay Vajpai, Shubham Prasad, Jatin Yegurla, Anugrah Dhooria, Vikas Banyal, Samagra Agarwal, Rajat Bansal, Sulagna Bhattacharjee, Richa Aggarwal, Kapil D. Soni, Swetha Rudravaram, Ashutosh K. Singh, Irfan Altaf, Avinash Choudekar, Soumya J. Mahapatra, Deepak Gunjan, Saurabh Kedia, Govind Makharia, Anjan Trikha, Pramod Garg, Anoop Saraya
      First page: 327
      Abstract: There is a paucity of data on the management of gastrointestinal (GI) bleeding in patients with Coronavirus disease -2019 (COVID-19) amid concerns about the risk of transmission during endoscopic procedures. We aimed to study the outcomes of conservative treatment for GI bleeding in patients with COVID-19.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-10-29
      DOI: 10.1016/j.jceh.2020.09.007
  • Recurrent and Treatment-Unresponsive Spontaneous Bacterial Peritonitis
           Worsens survival in Decompensated Liver Cirrhosis
    • Authors: Edmondo Falleti; Sara Cmet, Anna R. Cussigh, Elena Salvador, Davide Bitetto, Ezio Fornasiere, Elisa Fumolo, Carlo Fabris, Pierluigi Toniutto
      First page: 334
      Abstract: Spontaneous bacterial peritonitis (SBP) remains a major complication of cirrhosis. However, the incidence and the real impact of SBP in determining patient survival rates remain unclear. This study aims to evaluate the incidence and risk factors for SBP development and the role of SBP in predicting transplant-free survival.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-09-25
      DOI: 10.1016/j.jceh.2020.08.010
  • Long-term Outcomes with Carvedilol versus Propranolol in Patients with
           Index Variceal Bleed: 6-year Follow-up Study
    • Authors: Sanchit Sharma; Samagra Agarwal, Deepak Gunjan, Kanav Kaushal, Abhinav Anand, Srikant Mohta, Shalimar, Anoop Saraya
      First page: 343
      Abstract: There is limited information on comparison of clinical outcomes with carvedilol for secondary prophylaxis following acute variceal bleed (AVB) when compared with propranolol. We report long-term clinical and safety outcomes of a randomised controlled trial comparing carvedilol with propranolol with respect to reduction in hepatic venous pressure gradient (HVPG) in patients after AVB.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-09-13
      DOI: 10.1016/j.jceh.2020.08.009
  • INASL-ISN Joint Position Statements on Management of Patients with
           Simultaneous Liver and Kidney Disease
    • Authors: Anil Arora; Ashish Kumar, Narayan Prasad, Ajay Duseja, Subrat K. Acharya, Sanjay K. Agarwal, Rakesh Aggarwal, Anil C. Anand, Anil K. Bhalla, Narendra S. Choudhary, Yogesh K. Chawla, Radha K. Dhiman, Vinod K. Dixit, Natarajan Gopalakrishnan, Ashwani Gupta, Umapati N. Hegde, Sanjiv Jasuja, Vivek Jha, Vijay Kher, Ajay Kumar, Kaushal Madan, Rakhi Maiwall, Rajendra P. Mathur, Suman L. Nayak, Gaurav Pandey, Rajendra Pandey, Pankaj Puri, Ramesh R. Rai, Sree B. Raju, Devinder S. Rana, Padaki N. Rao, Manish Rathi, Vivek A. Saraswat, Sanjiv Saxena, Shalimar, Praveen Sharma, Shivaram P. Singh, Ashwani K. Singal, Arvinder S. Soin, Sunil Taneja, Santosh Varughese
      First page: 354
      Abstract: Renal dysfunction is very common among patients with chronic liver disease, and concomitant liver disease can occur among patients with chronic kidney disease. The spectrum of clinical presentation and underlying etiology is wide when concomitant kidney and liver disease occur in the same patient. Management of these patients with dual onslaught is challenging and requires a team approach of hepatologists and nephrologists. No recent guidelines exist on algorithmic approach toward diagnosis and management of these challenging patients.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-11-22
      DOI: 10.1016/j.jceh.2020.09.005
  • Recidivism in Liver Transplant Recipients for Alcohol-related Liver
    • Authors: Narendra S. Choudhary; Neeraj Saraf, Saurabh Mehrotra, Sanjiv Saigal, Arvinder S. Soin
      First page: 387
      Abstract: Liver transplantation (LT) is the only cure for patients with end-stage liver disease, which offers good long-term survival. The long-term issues after LT affecting survival are cardiovascular disease, chronic kidney disease, de novo malignancies, recurrence of original disease and immunological causes. Alcoholic-related liver disease (ALD) is one of the most common indications for LT worldwide including India. LT for ALD is associated with several unique challenges as compared with other etiologies.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-09-26
      DOI: 10.1016/j.jceh.2020.08.011
  • Recurrent Hepatic Encephalopathy Due to Surgically Created Shunt During
           Living Donor Liver Transplantation
    • Authors: Narendra S. Choudhary; Sanjiv Saigal, Neeraj Saraf, Sanjay S. Baijal, Arvinder S. Soin
      First page: 397
      Abstract: Hepatic encephalopathy due to portosystemic shunts is a well-defined entity in patients with cirrhosis. Rarely, liver transplant recipients develop hepatic encephalopathy owing to persistence or surgically created portosystemic shunts. We present a case of post-transplant recurrent hepatic encephalopathy due to a surgically created portocaval shunt. The patient was managed by a covered metal stent placement in the inferior vena cava, thus causing functional closure of the shunt.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-09-11
      DOI: 10.1016/j.jceh.2020.08.004
  • Chronic Hepatitis E With Genotype 1—Masquerading as Allograft Rejection
           After LiverTransplantation
    • Authors: Sahaj Rathi; Ajay Duseja, Vikram Thakur, Radha K. Ratho, Mini P. Singh, Sunil Taneja, Ashim Das, Rakesh Aggarwal, Radha K. Dhiman, Yogesh K. Chawla
      First page: 400
      Abstract: Hepatitis E is one of the leading causes of acute viral hepatitis worldwide. Chronic infection with hepatitis E is less common and limited to immunosuppressed patients and is usually due to genotype 3 of the virus. Genotype 1, the most prevalent strain in the South Asian region, is seldom known to be associated with chronic hepatitis. Here we describe a case of chronic hepatitis E with genotype 1 in a post-liver transplant setting. In the index case, previously compensated cryptogenic cirrhosis was decompensated by an acute hepatitis E infection, which necessitated liver transplantation because of acute chronic liver failure.
      Citation: Journal of Clinical and Experimental Hepatology (2020)
      PubDate: 2020-08-15
      DOI: 10.1016/j.jceh.2020.07.006
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