Subjects -> MEDICAL SCIENCES (Total: 8810 journals)
    - ALLERGOLOGY AND IMMUNOLOGY (225 journals)
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    - INTERNAL MEDICINE (180 journals)
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    - SPORTS MEDICINE (83 journals)
    - SURGERY (412 journals)
    - UROLOGY, NEPHROLOGY AND ANDROLOGY (159 journals)

INTERNAL MEDICINE (180 journals)                     

Showing 1 - 180 of 180 Journals sorted alphabetically
Abdomen     Open Access  
ACP Hospitalist     Full-text available via subscription   (Followers: 9)
ACP Internist     Full-text available via subscription   (Followers: 10)
ACP Journal Club     Full-text available via subscription   (Followers: 11)
Acta Clinica Belgica     Hybrid Journal   (Followers: 1)
Acute and Critical Care     Open Access   (Followers: 11)
Acute Medicine     Full-text available via subscription   (Followers: 9)
Advances in Hepatology     Open Access   (Followers: 4)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6)
African Journal of Primary Health Care & Family Medicine     Open Access   (Followers: 6)
African Journal of Thoracic and Critical Care Medicine     Open Access  
American Family Physician     Full-text available via subscription   (Followers: 38)
American Journal of Hypertension     Hybrid Journal   (Followers: 31)
Anales de Medicina Interna     Open Access   (Followers: 1)
Anatomy & Physiology : Current Research     Open Access   (Followers: 9)
Angiology     Hybrid Journal   (Followers: 5)
Annals of Colorectal Research     Open Access   (Followers: 1)
Annals of Internal Medicine     Full-text available via subscription   (Followers: 392)
AORN Journal     Hybrid Journal   (Followers: 27)
Apollo Medicine     Open Access  
Archives of Drug Information     Hybrid Journal   (Followers: 5)
Archivos de Medicina Interna     Open Access   (Followers: 1)
Asia Oceania Journal of Nuclear Medicine & Biology     Open Access   (Followers: 4)
Asian Pacific Journal of Tropical Disease     Full-text available via subscription   (Followers: 3)
Australasian Physical & Engineering Sciences in Medicine     Hybrid Journal   (Followers: 1)
BMI Journal : Bariátrica & Metabólica Iberoamericana     Open Access   (Followers: 1)
BMJ Open Diabetes Research & Care     Open Access   (Followers: 35)
BMJ Quality & Safety     Hybrid Journal   (Followers: 69)
Bone & Joint Journal     Hybrid Journal   (Followers: 138)
Brain Communications     Open Access   (Followers: 4)
Brain Science Advances     Open Access  
Canadian Journal of General Internal Medicine     Open Access   (Followers: 2)
Cardiovascular Medicine in General Practice     Full-text available via subscription   (Followers: 7)
Case Reports in Internal Medicine     Open Access   (Followers: 1)
Cell Death & Disease     Open Access   (Followers: 3)
Cellular and Molecular Gastroenterology and Hepatology     Open Access   (Followers: 3)
Cephalalgia     Hybrid Journal   (Followers: 8)
Cephalalgia Reports     Open Access   (Followers: 4)
Chronic Diseases and Injuries in Canada     Free   (Followers: 1)
Clinical Ethics     Hybrid Journal   (Followers: 13)
Clinical Liver Disease     Open Access   (Followers: 5)
Clinical Nutrition     Hybrid Journal   (Followers: 98)
Clinical Thyroidology     Full-text available via subscription   (Followers: 1)
CNE Pflegemanagement     Hybrid Journal  
Communication Law and Policy     Hybrid Journal   (Followers: 5)
Current Diabetes Reports     Hybrid Journal   (Followers: 30)
Current Hepatology Reports     Hybrid Journal  
Current Research: Integrative Medicine     Open Access  
CVIR Endovascular     Open Access   (Followers: 1)
Der Internist     Hybrid Journal   (Followers: 12)
Diabetes     Full-text available via subscription   (Followers: 603)
Diabetes Care     Full-text available via subscription   (Followers: 578)
Diabetes Internacional     Open Access  
Diabetes Spectrum     Full-text available via subscription   (Followers: 17)
Diagnosis     Hybrid Journal   (Followers: 1)
Egyptian Journal of Bronchology     Open Access  
Egyptian Journal of Internal Medicine     Open Access   (Followers: 1)
Egyptian Journal of Neurosurgery     Open Access  
Egyptian Liver Journal     Open Access   (Followers: 2)
Egyptian Spine Journal     Open Access  
EMC - Aparato Locomotor     Hybrid Journal  
Endovascular Neuroradiology / Ендоваскулярна нейрорентгенохірургія     Open Access   (Followers: 1)
eNeuro     Open Access   (Followers: 3)
Ergonomics     Hybrid Journal   (Followers: 24)
European Journal of Inflammation     Open Access   (Followers: 2)
European Journal of Internal Medicine     Full-text available via subscription   (Followers: 10)
European Journal of Translational Myology     Open Access  
European Radiology Experimental     Open Access   (Followers: 2)
Head and Neck Tumors     Open Access   (Followers: 1)
Health Sociology Review     Hybrid Journal   (Followers: 14)
HemaSphere     Open Access   (Followers: 2)
Hepatology Communications     Open Access  
Hepatoma Research     Open Access   (Followers: 3)
Human Physiology     Hybrid Journal   (Followers: 5)
ImmunoHorizons     Open Access  
Immunological Medicine     Open Access  
Infectious Diseases: Research and Treatment     Open Access   (Followers: 5)
Inflammation and Regeneration     Open Access   (Followers: 2)
Inflammatory Intestinal Diseases     Open Access  
Innere Medizin up2date     Hybrid Journal   (Followers: 1)
Internal and Emergency Medicine     Hybrid Journal   (Followers: 5)
Internal Medicine Journal     Hybrid Journal   (Followers: 9)
International Journal of Abdominal Wall and Hernia Surgery     Open Access   (Followers: 1)
International Journal of Anatomy and Research     Open Access   (Followers: 2)
International Journal of Angiology     Hybrid Journal  
International Journal of Artificial Organs     Hybrid Journal   (Followers: 3)
International Journal of Hyperthermia     Open Access  
International Journal of Internal Medicine     Open Access   (Followers: 3)
International Journal of Noncommunicable Diseases     Open Access  
International Journal of Psychiatry in Clinical Practice     Hybrid Journal   (Followers: 6)
Iranian Journal of Neurosurgery     Open Access   (Followers: 1)
Italian Journal of Anatomy and Embryology     Open Access   (Followers: 1)
JAC-Antimicrobial Resistance     Open Access   (Followers: 4)
JAMA Internal Medicine     Full-text available via subscription   (Followers: 364)
JCSM Clinical Reports     Open Access   (Followers: 3)
JHEP Reports     Open Access  
JIMD Reports     Open Access  
JMV - Journal de Médecine Vasculaire     Hybrid Journal   (Followers: 1)
Joint Commission Journal on Quality and Patient Safety     Hybrid Journal   (Followers: 41)
JOP. Journal of the Pancreas     Open Access   (Followers: 2)
Journal of Basic & Clinical Physiology & Pharmacology     Hybrid Journal   (Followers: 1)
Journal of Bone Oncology     Open Access   (Followers: 1)
Journal of Cancer & Allied Specialties     Open Access  
Journal of Clinical and Experimental Hepatology     Full-text available via subscription   (Followers: 3)
Journal of Clinical Movement Disorders     Open Access   (Followers: 3)
Journal of Community Hospital Internal Medicine Perspectives     Open Access  
Journal of Cutaneous Immunology and Allergy     Open Access  
Journal of Developmental Origins of Health and Disease     Hybrid Journal   (Followers: 2)
Journal of Endoluminal Endourology     Open Access  
Journal of Gastroenterology and Hepatology Research     Open Access   (Followers: 4)
Journal of General Internal Medicine     Hybrid Journal   (Followers: 23)
Journal of Hypertension     Hybrid Journal   (Followers: 14)
Journal of Infectious Diseases     Hybrid Journal   (Followers: 48)
Journal of Interdisciplinary Medicine     Open Access  
Journal of Internal Medicine     Hybrid Journal   (Followers: 11)
Journal of Liver : Disease & Transplantation     Hybrid Journal   (Followers: 7)
Journal of Medical Internet Research     Open Access   (Followers: 24)
Journal of Movement Disorders     Open Access   (Followers: 2)
Journal of Pain and Symptom Management     Hybrid Journal   (Followers: 46)
Journal of Pancreatic Cancer     Open Access  
Journal of Renal and Hepatic Disorders     Open Access  
Journal of Solid Tumors     Open Access   (Followers: 1)
Journal of Sports Medicine and Allied Health Sciences : Official Journal of the Ohio Athletic Trainers Association     Open Access   (Followers: 1)
Journal of the American Board of Family Medicine     Open Access   (Followers: 11)
Journal of the European Mosquito Control Association     Open Access  
Journal of Translational Internal Medicine     Open Access  
Jurnal Vektor Penyakit     Open Access  
La Revue de Medecine Interne     Full-text available via subscription   (Followers: 3)
Lege artis - Das Magazin zur ärztlichen Weiterbildung     Hybrid Journal   (Followers: 1)
Liver Cancer International     Open Access  
Liver Research     Open Access  
Molecular Diagnosis & Therapy     Hybrid Journal   (Followers: 3)
Molecular Therapy - Oncolytics     Open Access  
Multiple Sclerosis and Demyelinating Disorders     Open Access   (Followers: 7)
MYOPAIN. A journal of myofascial pain and fibromyalgia     Hybrid Journal   (Followers: 18)
Neuro-Oncology Advances     Open Access   (Followers: 1)
Neurobiology of Pain     Open Access   (Followers: 2)
Neurointervention     Open Access   (Followers: 6)
Neuromuscular Diseases     Open Access  
Nigerian Journal of Gastroenterology and Hepatology     Full-text available via subscription  
OA Alcohol     Open Access   (Followers: 5)
Oncological Coloproctology     Open Access  
Open Journal of Internal Medicine     Open Access  
Pleura and Peritoneum     Open Access  
Pneumo News     Full-text available via subscription  
Polish Archives of Internal Medicine     Full-text available via subscription   (Followers: 2)
Preventing Chronic Disease     Free   (Followers: 2)
Progress in Transplantation     Hybrid Journal   (Followers: 1)
Prostate International     Open Access   (Followers: 2)
Psychiatry and Clinical Psychopharmacology     Open Access   (Followers: 1)
Pulmonary Therapy     Open Access   (Followers: 2)
Quality of Life Research     Hybrid Journal   (Followers: 20)
Research and Practice in Thrombosis and Haemostasis     Open Access  
Revista Chilena de Fonoaudiología     Open Access   (Followers: 1)
Revista de la Sociedad Peruana de Medicina Interna     Open Access   (Followers: 4)
Revista del Instituto de Medicina Tropical     Open Access  
Revista Hispanoamericana de Hernia     Open Access   (Followers: 1)
Revista Médica Internacional sobre el Síndrome de Down     Full-text available via subscription   (Followers: 1)
Revista Virtual de la Sociedad Paraguaya de Medicina Interna     Open Access   (Followers: 1)
Romanian Journal of Diabetes Nutrition and Metabolic Diseases     Open Access   (Followers: 1)
Romanian Journal of Internal Medicine     Open Access  
Russian Journal of Child Neurology     Open Access   (Followers: 1)
Scandinavian Journal of Primary Health Care     Open Access   (Followers: 8)
Schlaf     Hybrid Journal  
Schmerzmedizin     Hybrid Journal  
Scientific Journal of the Foot & Ankle     Open Access   (Followers: 1)
SciMedicine Journal     Open Access   (Followers: 3)
SEMERGEN - Medicina de Familia     Full-text available via subscription   (Followers: 1)
The Journal of Critical Care Medicine     Open Access   (Followers: 9)
Therapeutic Advances in Chronic Disease     Open Access   (Followers: 8)
Therapeutic Advances in Musculoskeletal Disease     Hybrid Journal   (Followers: 6)
Thieme Case Report     Hybrid Journal   (Followers: 1)
Tijdschrift voor Urologie     Hybrid Journal  
Tissue Barriers     Hybrid Journal   (Followers: 1)
Transactions of the Royal Society of Tropical Medicine and Hygiene     Hybrid Journal   (Followers: 3)
Transgender Health     Open Access   (Followers: 3)
Trends in Anaesthesia and Critical Care     Full-text available via subscription   (Followers: 23)
US Cardiology Review     Open Access  
Vascular and Endovascular Review     Open Access   (Followers: 1)
Ожирение и метаболизм     Open Access  

           

Similar Journals
Journal Cover
Annals of Internal Medicine
Journal Prestige (SJR): 7.466
Citation Impact (citeScore): 4
Number of Followers: 392  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0003-4819 - ISSN (Online) 1539-3704
Published by American College of Physicians Homepage  [4 journals]
  • Annals for Educators - 5 May 2020
    • Authors: Taichman DB.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Annals On Call - Striving to Decrease Hospital Infection
    • Authors: Centor RM; Meddings J.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Annals Graphic Medicine - Dr. Mom: Little Pharma
    • Authors: Farris GE.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Annals Graphic Medicine - White Coat
    • Authors: Taing L.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Eosinophilic Esophagitis
    • Authors: Katzka DA.
      Abstract: Eosinophilic esophagitis (EoE) is a relatively new disease that has reached an incidence similar to that of Crohn disease and ulcerative colitis. With this increased presence, greater recognition is essential. This applies both to children with nonspecific but potentially debilitating symptoms and to adults who have spent years behaviorally compensating for narrow esophageal strictures. The pathogenesis of EoE is rapidly being unraveled and is based on initiation of a type II allergic response to specific food antigens, leading to dense esophageal eosinophilia, chronic inflammation, and esophageal fibrosis. With greater familiarity and understanding of EoE, treatments are evolving, including identification and avoidance of food antigens; broad applications of topical steroids; and, eventually, pathway-specific biologic therapy.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Correction: In the Clinic: Acute Colonic Diverticulitis
    • PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Correction: Recommended Adult Immunization Schedule, United States, 2020
    • PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Unprocessed Red Meat and Processed Meat Consumption
    • Authors: Johnston BC; Zeraatkar D, Vernooij RM, et al.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Unprocessed Red Meat and Processed Meat Consumption
    • Authors: Gong CL; Zawadzki NK, Zawadzki R, et al.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Unprocessed Red Meat and Processed Meat Consumption
    • Authors: Wan Y; Wang F.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Unprocessed Red Meat and Processed Meat Consumption
    • Authors: Rosenfeld RM.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Unprocessed Red Meat and Processed Meat Consumption
    • Authors: Westman EC.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Unprocessed Red Meat and Processed Meat Consumption
    • Authors: Meyer DA.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Annals Graphic Medicine - One of My Demons: Crying (or a Lack of)
    • Authors: Bellchambers AS.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Annals Clinical Decision Making: Translating Population Evidence to
           Individual Patients
    • Authors: Armstrong KA; Metlay JP.
      Abstract: This paper in the Annals Clinical Decision Making series explains a practical approach to evaluating whether the conclusions of studies involving many patients or whole populations may be confidently applied to the care of an individual patient.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Clinical Decision Making: Nurturing Our Core Skills
    • Authors: Taichman DB; Williams SV, Laine C.
      Abstract: Making diagnostic and management decisions is the core skill of physicians. The editors introduce the Annals Clinical Decision Making series, a collection of coordinated articles designed to help all physicians hone their skills.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Annals Clinical Decision Making: Weighing Evidence to Inform Clinical
           Decisions
    • Authors: Metlay JP; Armstrong KA.
      Abstract: Deciding when recently published evidence should alter practice can be daunting. This article in the Annals Clinical Decision Making series discusses the care of a patient with a common problem and recently published studies to illustrate an approach to weighing new evidence not yet considered by practice guidelines that conflicts with existing recommendations.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Annals Clinical Decision Making: Using a Diagnostic Test
    • Authors: Armstrong KA; Metlay JP.
      Abstract: Diagnostic testing is an essential tool in clinical decision making. This article in the Annals Clinical Decision Making series reviews core principles underlying the approach to choosing and interpreting diagnostic tests for individual patients.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Annals On Call - COVID-19: Is Chloroquine the Answer'
    • Authors: Centor RM; Kim A, Sparks JA.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Annals Graphic Medicine - True Tales From the Outbreak: Life in the Hot
           Zone
    • Authors: Thomas A.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Isradipine Versus Placebo in Early Parkinson Disease
    • PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Love in the Time of Corona
    • Authors: Benatti SV.
      Abstract: One of the most painful aspects of this pandemic is the irremediable separation of patients from their families at the end of their lives.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • A Clinical Trial of Isradipine: What Went Wrong'
    • Authors: Maiti B; Perlmutter JS.
      Abstract: The Parkinson Study Group STEADY-PD III Investigators reported the results of a randomized controlled trial evaluating the effect of isradipine, a dihydropyridine calcium-channel blocker, on clinical progression of Parkinson disease. The editorialists discuss the findings and the need for more reliable in vivo biomarkers of Parkinson disease progression and measures of specific target engagement.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Isradipine Versus Placebo in Early Parkinson Disease A Randomized Trial
    • Authors: .
      Abstract: Background:Studies suggest that dihydropyridine calcium-channel blockers may be associated with reduced risk for Parkinson disease (PD).Objective:To assess the effect of isradipine, a dihydropyridine calcium-channel blocker, on the rate of clinical progression of PD.Design:Multicenter, randomized, parallel-group, double-blind, placebo-controlled trial. (ClinicalTrials.gov: NCT02168842)Setting:57 Parkinson Study Group sites in North America.Participants:Patients with early-stage PD (duration <3 years) who were not taking dopaminergic medications at enrollment.Intervention:5 mg of immediate-release isradipine twice daily or placebo for 36 months.Measurements:The primary outcome was change in the Unified Parkinson's Disease Rating Scale (UPDRS) parts I to III score measured in the antiparkinson medication “ON” state between baseline and 36 months. Secondary outcomes included time to initiation and use of antiparkinson medications, time to onset of motor complications, change in nonmotor disability, and quality-of-life measures.Results:336 patients were randomly assigned (mean age, 62 years [SD, 9]; 68% men; disease duration, 0.9 year [SD, 0.7]; mean UPDRS part I to III score, 23.1 [SD, 8.6]); 95% of patients completed the study. Adjusted least-squares mean changes in total UPDRS score in the antiparkinson medication ON state over 36 months for isradipine and placebo recipients were 2.99 (95% CI, 0.95 to 5.03) points versus 3.26 (CI, 1.25 to 5.26) points, respectively, with a treatment effect of −0.27 (CI, −3.02 to 2.48) point (P = 0.85). Statistical adjustment for antiparkinson medication use did not change the findings. Secondary outcomes showed no effect of isradipine treatment. The most common adverse effects of isradipine were edema and dizziness.Limitation:The isradipine dose may have been insufficient to engage the target calcium channels associated with neuroprotective effects.Conclusion:Long-term treatment with immediate-release isradipine did not slow the clinical progression of early-stage PD.Primary Funding Source:National Institute of Neurological Disorders and Stroke.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Improving How State Medical Boards Ask Physicians About Mental Health
           Diagnoses: A Case Study From New Mexico
    • Authors: Barrett E; Lawrence E, Waldman D, et al.
      Abstract: State-based medical license applications often ask about mental health diagnoses and treatment in terms that stigmatize mental illness, which inadvertently discourages physicians from seeking care. In this article, the authors describe a recent collaboration that resulted in updated and destigmatized language on their state's medical license application.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Histopathologic Changes and SARS-CoV-2 Immunostaining in the Lung of a
           Patient With COVID-19
    • Authors: Zhang H; Zhou P, Wei Y, et al.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • How Should U.S. Hospitals Prepare for Coronavirus Disease 2019
           (COVID-19)'
    • Authors: Chopra V; Toner E, Waldhorn R, et al.
      Abstract: Estimates suggest that COVID-19 will stress bed capacity, equipment, and health care personnel in U.S. hospitals in ways not previously experienced. How can health systems prepare to care for a large influx of patients with this disease'
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Coronavirus Disease 2019 (COVID-19): Protecting Hospitals From the
           Invisible
    • Authors: Klompas M.
      Abstract: COVID-19 is optimized to spread widely: Its signs and symptoms are largely indistinguishable from those of other respiratory viruses. This commentary specifically addresses best ways to protect our hospitals against COVID-19.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • How Much Are We Willing to Pay for Preexposure Prophylaxis in the United
           States'
    • Authors: del Rio C; Armstrong WS.
      Abstract: Walensky and colleagues' cost-effectiveness analysis estimated the potential clinical benefits of tenofovir alafenamide–emtricitabine (F/TAF) and the resultant cost savings of lower risk for renal failure and fractures versus the increased cost of branded F/TAF compared with generic tenofovir disoproxil fumarate–emtricitabine for HIV preexposure prophylaxis (PrEP). The editorialists believe that the findings make it clear that shifting to F/TAF as first-line PrEP for all should not be universally recommended if the goal is to end AIDS in the United States.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly
           Reported Confirmed Cases: Estimation and Application
    • Authors: Lauer SA; Grantz KH, Bi Q, et al.
      Abstract: Background:A novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified in China in December 2019. There is limited support for many of its key epidemiologic features, including the incubation period for clinical disease (coronavirus disease 2019 [COVID-19]), which has important implications for surveillance and control activities.Objective:To estimate the length of the incubation period of COVID-19 and describe its public health implications.Design:Pooled analysis of confirmed COVID-19 cases reported between 4 January 2020 and 24 February 2020.Setting:News reports and press releases from 50 provinces, regions, and countries outside Wuhan, Hubei province, China.Participants:Persons with confirmed SARS-CoV-2 infection outside Hubei province, China.Measurements:Patient demographic characteristics and dates and times of possible exposure, symptom onset, fever onset, and hospitalization.Results:There were 181 confirmed cases with identifiable exposure and symptom onset windows to estimate the incubation period of COVID-19. The median incubation period was estimated to be 5.1 days (95% CI, 4.5 to 5.8 days), and 97.5% of those who develop symptoms will do so within 11.5 days (CI, 8.2 to 15.6 days) of infection. These estimates imply that, under conservative assumptions, 101 out of every 10 000 cases (99th percentile, 482) will develop symptoms after 14 days of active monitoring or quarantine.Limitation:Publicly reported cases may overrepresent severe cases, the incubation period for which may differ from that of mild cases.Conclusion:This work provides additional evidence for a median incubation period for COVID-19 of approximately 5 days, similar to SARS. Our results support current proposals for the length of quarantine or active monitoring of persons potentially exposed to SARS-CoV-2, although longer monitoring periods might be justified in extreme cases.Primary Funding Source:U.S. Centers for Disease Control and Prevention, National Institute of Allergy and Infectious Diseases, National Institute of General Medical Sciences, and Alexander von Humboldt Foundation.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Comparative Pricing of Branded Tenofovir Alafenamide–Emtricitabine
           Relative to Generic Tenofovir Disoproxil Fumarate–Emtricitabine for HIV
           Preexposure Prophylaxis A Cost-Effectiveness Analysis
    • Authors: Walensky RP; Horn T, McCann NC, et al.
      Abstract: Background:Tenofovir alafenamide–emtricitabine (F/TAF) was recently approved as a noninferior and potentially safer option than tenofovir disoproxil fumarate–emtricitabine (F/TDF) for HIV preexposure prophylaxis (PrEP) in the United States.Objective:To estimate the greatest possible clinical benefits and economic savings attributable to the improved safety profile of F/TAF and the maximum price payers should be willing to pay for F/TAF over generic F/TDF.Design:Cost-effectiveness analysis.Data Sources:Published literature on F/TDF safety (in persons with and those without HIV) and the cost and quality-of-life effects of fractures and end-stage renal disease (ESRD).Target Population:Age-stratified U.S. men who have sex with men (MSM) using PrEP.Time Horizon:Five years.Perspective:Health care sector.Intervention:Preexposure prophylaxis with F/TAF versus F/TDF.Outcome Measures:Fractures averted, cases of ESRD averted, quality-adjusted life-years (QALYs) saved, costs, incremental cost-effectiveness ratios (ICERs), and maximum justifiable price for F/TAF compared with generic F/TDF.Results of Base-Case Analysis:Over a 5-year horizon, compared with F/TDF, F/TAF averted 2101 fractures and 25 cases of ESRD for the 123 610 MSM receiving PrEP, with an ICER of more than $7 million per QALY. At a 50% discount for generic F/TDF ($8300 per year) and a societal willingness to pay up to $100 000 per QALY, the maximum fair price for F/TAF was $8670 per year.Results of Sensitivity Analysis:Among persons older than 55 years, the ICER for F/TAF remained more than $3 million per QALY and the maximum permissible fair price for F/TAF was $8970 per year. Results were robust to alternative time horizons and PrEP-using population sizes.Limitation:Intermittent use and on-demand PrEP were not considered.Conclusion:In the presence of a generic F/TDF alternative, the improved safety of F/TAF is worth no more than an additional $370 per person per year.Primary Funding Source:National Institute of Allergy and Infectious Diseases, National Institute on Drug Abuse, National Institute of Mental Health, and Massachusetts General Hospital Executive Committee on Research.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Unilateral Facial Paralysis During an Airline Flight
    • Authors: Hunter AJ.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
  • Unwanted Medication Disposal: Audit of California Pharmacy Advice
    • Authors: Selekman RE; Gaither TW, Kornberg Z, et al.
      PubDate: Tue, 05 May 2020 00:00:00 GMT
       
 
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