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Translational Research in Urology
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This is an Open Access Journal

Open Access journal
ISSN (Online) 2717-042X
Published by Tehran University of Medical Sciences

[28 journals]

Synergistic Effect of Curcumin on Controlling Irritative Urinary Symptoms
After Benign Prostatic Enlargement Endoscopic Surgery Compared with
Anticholinergic Therapy Alone
- Abstract: Introduction: Benign prostatic hyperplasia is a common condition in older males that causes bothersome symptoms. The purpose of this study is to evaluate the combined impact of curcumin and anticholinergic therapy in managing urinary irritation symptoms in patients with benign prostatic hyperplasia following prostate surgery.Methods: This randomized clinical trial included patients with benign prostate hyperplasia who experienced irritating symptoms after prostate surgery at Imam Reza Hospital in Mashhad from 2019–2020. Participants completed the IPSS questionnaire before the operation and were then classified into two groups. One group received anticholinergic therapy, and the other group received anticholinergic therapy plus curcumin BID for one month. The IPSS was used again at the end of one month, and results were analyzed using SPSS statistical software.Results: 80 participants were included in this research, with an average age of 63.4±13.5 years in the control group and 64.6±9.5 years in the intervention group. Before the intervention, scores for urinary frequency (P-value=0.333), urinary urgency (P-value=0.387), nocturia (P-value=0.807), and total urinary symptom score (P-value=0.061) differed between the two groups. However, after the study, the intervention group had significantly lower scores for urinary frequency, urinary urgency, and total urinary symptom score compared to the control group (P-value<0.05). No significant difference was between two groups considering nocturia (P-value=0.051).Conclusion: This investigation was one of the first randomized clinical trials to evaluate curcumin's effects on reducing symptoms of benign prostatic hyperplasia. The results indicated that curcumin positively impacted decreasing these symptoms, although changes in nocturia were not significant.
Investigating Genetic and Environmental Factors in Testicular Cancer’s
Development: A Review Study
- Abstract: Testicular cancer (TC) is among the specific clinical problems of our time. Current therapy is highly effective, confirming 5-year disease-free survival in approximately 95% of ill people. TC is a prevalent type of cancer diagnosed in males between 14 and 44 ages, with an incidence of less than 1 in 9.9 cases per 100,000 men nationwide, but the total number of TC. Increase worldwide. In addition, the danger of expanding cancer in people with cancer during 15 years after diagnosis is 2%. These complicated and different conditions must be found in the clinical evidence base. Genetic, environmental, and hormonal elements are related to developing diseases and disorders in response to treatment and danger of relapse. This research discusses current topics that explain the relative contribution of the problems mentioned above to TC development. Additionally, we pay attention to environmental chemicals and heat exposure, their function in cancer development, and recent advances at the molecular level have been studied.
Endourological Management of Bladder Mass following Herniorrhaphy
- Abstract: ABSTRACTIntroduction: In this article, we reported bladder mass arising from a reaction to silk material used to manage missed bladder hernia repair. Case Presentation: The patient was a 47-year-old man presenting with urinary symptoms. CT scan identified a 6-cm heterogeneous appearance mass on the right side of the bladder dome; initial Biopsy revealed no malignancy. The patient underwent deep transurethral resection (TUR), following which silk suture materials were removed by endourologic management. Histopathologically the tumor represented inflammatory granuloma. The patient had significant improvement and gradual resolution of the residual mass at 6-month and one-year follow-ups. Conclusion: By TUR, silk suture materials were removed and inflammatory granuloma was treated.
Comparison of Conventional Cigarette and Electronic Cigarettes on P53,
PTEN, and VEGF Genes Expression in Rat Kidney
- Abstract: Introduction: Various genetic alterations and gene expression changes are involved in the pathogenesis of kidney tumours. The P53, PTEN, and VEGF gene expression pattern in rat kidney tissue exposed to conventional cigarettes and e-cigs was evaluated.Method: In the study, 60 Wistar rats were categorized into three groups (10): no smoke, c-cig smoke, and e-cig smoke. Three cigarette butts used daily with the suction device were exposed for 40 minutes. After four months, kidney tissue was removed, tissue RNA was extracted, cDNA was made, and changes in mRNA expression of genes were evaluated by real-time PCR. Moreover, kidney biopsies were assessed for histopathological changes.Result: E-cig smoke might contribute to kidney cancer more than C-cigarette through upregulating VEGF and downregulating PTEN and P53 (P-value >0.05). The effect of e-cigarettes in female rats was more significant than in male rats. The histopathological investigation revealed decreased glomerular space in e-cig male rats, increased tubular necrosis in e-cig, Interstitial infiltration in c-cig, and Hyperemia in c-cig in female rats were reported.Conclusion: Since E-cigarette smoke displayed overexpressed VEGF and down-expressed PTEN and P53 expression than C-cigarette, it has a higher potential for kidney carcinogenesis. 
Beyond Science Fiction: Xenotransplantation Becoming Clinical Reality
- Abstract: The growing demand for organ transplants has led to a shortage of available organs. This shortage has contributed to crises such as illegal organ trafficking and transplant tourism. However, recent progress in xenotransplantation may help alleviate this shortage. With current successes transplanting pig organs into non-human primate models and deceased patients, companies are spending a great deal of money on establishing pathogen-free pig facilities and gaining FDA approval to move toward clinical trials. Given this progress, it is worthwhile to examine the current state of xenotransplantation and ongoing approaches to modifying porcine organs to make them safe for clinical use in humans.
Evaluation of Liver Enzymes, Hematologic and Coagulation Factors in
Patients with Chronic Kidney Disease
- Abstract: Introduction: Chronic Kidney Disease (CKD) is a condition where the kidneys have abnormal structure or function that lasts for more than three months, can have negative health effects, and often does not show symptoms in the beginning. In that research, we tried to examine the diagnostic markers from the laboratory to find clues for a faster diagnosis of this disease.Methods: This paper is a cross-sectional analytical study on 107 patients with CKD hospitalized in Abadan University of Medical Sciences educational hospitals from March 21, 2017, to March 19, 2020. Once the necessary permits were obtained, the laboratory information of patients was received from HIS. The data was analyzed by SPSS version 16 software. Statistical significance is considered when P-value>0.05.Results: Out of 107 patients with CKD in the study, 55 (51.4%) were female and 52 (48.6%) were male. The mean age of the group was 57.9±17.42 years. The means of renal diagnostic markers such as creatinine 7.42±4.55 and BUN 56.97±36.78 were higher than normal. Also, the mean coagulation markers, including PT (15.86±9.89), PTT (47.65±29.11), and INR (1.54±1.07), were higher than normal. The mean of hematological diagnostic markers, including hemoglobin and hematocrit, was lower than normal. The mean RDW-CV (16.97±4.19) and white blood cells (11.19±9.01) were higher than normal.Conclusions: This study showed that renal markers (creatinine and BUN) and coagulation factors (PT, PTT, and INR) were higher than normal. In this study, it was observed that people with CKD are prone to anemia because a decrease in the mean hemoglobin and hematocrit and an increase in RDW-CV were observed.
Laparoscopic management of huge adrenal cyst: case report and literature
review
- Abstract: Introduction: Cystic lesions in adrenal glands are not common and have a wide range in diameter, even to 30 centimeters in the reports. They may have some hormonal activities, but most of them do have not hormonal functions. Simple adrenal cysts often have four pathologic types, and endothelial cysts are the most common. It seems that the best treatment for these cysts is complete excision of them because of the slight risk of malignancy, and of course, it is better to be done in a laparoscopic manner with fewer complications, post-surgery pain, and blood loss. Case presentation: We reported two cases with adrenal cystic lesions, a 35 y/o woman and a 30 y/o man with a large cystic mass in the upper pole of the left kidney (80 mm and 90 mm respectively), who were referred to our center. Both patients underwent intraperitoneal laparoscopic partial adrenalectomy and the pathology reports of both masses were endothelial adrenal cysts, and in 12 months of follow-up, no complication or recurrence was reported.Conclusion: In symptomatic patients with no malignancy evidence, laparoscopic surgery inclusive of cyst excision, partial or total adrenalectomy is a safe procedure and excellent result besides open surgery.