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Kidneys (Počki)
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This is an Open Access Journal

Open Access journal
ISSN (Print) 2307-1257 - ISSN (Online) 2307-1265
Published by Publishing House Zaslavsky

[9 journals]

Appeal of Editor-in-Chief
- Authors: No authors
  Pages: 95 - 95
  Abstract: No abstract
  PubDate: 2024-06-16
  DOI: 10.22141/2307-1257.13.2.2024.450
  Issue No: Vol. 13, No. 2 (2024)
What can a tandem of a pathophysiologist and a clinician bring to clinical
practice'
- Authors: A.I. Gozhenko, D.D. Ivanov
  Pages: 96 - 100
  Abstract: Kidney diseases, starting from acute kidney injury, acute kidney disease, or having an uncertain onset, often progress to chronic kidney disease (CKD). The pathomorphosis of this progression typically involves predominant damage to the glomerulus, affecting either the glomerular filter or the tubules, primarily in the proximal part. International guidelines identify two key indicators for determining the prognosis and progression of CKD: albuminuria and glomerular filtration rate. Additional criteria, such as blood pressure, pathomorphological changes, or multifactorial calculators, are usually proposed for specific nosological forms. However, accurately predicting CKD progression remains a challenging issue. We propose using renal functional reserve to estimate the number of functioning nephrons. Together with blood pressure, degrees of albuminuria, and glomerular filtration rate, this approach provides a more accurate assessment of the future course of CKD.
  PubDate: 2024-06-16
  DOI: 10.22141/2307-1257.13.2.2024.451
  Issue No: Vol. 13, No. 2 (2024)
Evaluation of the index of resistance and excretion of uromodulin in
patients with predialysis CKD, taking into account the index of
comorbidity
- Authors: L.D. Denova
  Pages: 101 - 115
  Abstract: Background. The purpose of this study was to investigate urinary uromodulin (uUMOD) excretion, reactivity of the autonomic nervous system and impaired renal blood circulation in patients with predialysis chronic kidney disease (CKD), the effect of antioxidant therapy on these parameters. Materials and methods. Ninety-one patients with CKD stage 1–5 whose average age was 47.00 ± 12.12 years took part in the ROLUNT (UROmoduLin UbiquinoNe GlutaThione) study. Thirty (32.97 %) men and 61 (67.03 %) women were divided into two groups, which were representative in terms of age and gender composition: group 1 (n = 46) — patients with CKD stage 1–5 who had a Charlson comorbidity index ≤ 2, group 2 (n = 45) — patients with CKD stage 1–5 who had a Charlson comorbidity index ≥ 3. Both groups were divided into subgroups A and B. Subgroups A included patients with impaired vegetative status, subgroups B — those without impaired vegetative status. The first A and second B subgroups took glutathione 100 mg twice a day with food for 3 months, the first B and second A subgroups took ubiquinone 100 mg once a day with food for 3 months. Results. The results of the paired t-test showed that there is a significant difference between the indicators at baseline and at the end of the study. The Pearson correlation results showed that in the group 1 (subgroup A), there is a significant average positive relationship between uUMOD and estimated glomerular filtration rate (r(21) = 0.418, p = 0.047); in the group 1 (subgroup B), there is a significant large positive relationship between uUMOD and Hb indicators (r(21) = 0.513, p = 0.012); a significant very small negative relationship between uUMOD and albumin-creatinine ratio (r(21) = 0.441, p = 0.035); in the group 2 (subgroup A), there is a significant very small negative relationship between uUMOD indicators and Kérdö index (r(20) = 0.427, p = 0.048); in the group 2 (subgroup B), there is a significant very small negative relationship between the uUMOD indicators and Yu.M. Chernov’s questionnaire (r(21) = 0.421, p = 0.045). Conclusions. Antioxidant therapy with glutathione and ubiquinone significantly affects the examination parameters in patients with CKD. Considering the safety and effectiveness of antioxidant therapy, we suggest including it in the treatment protocols for patients with CKD. Further research is recommended to develop a standard protocol.
  PubDate: 2024-06-16
  DOI: 10.22141/2307-1257.13.2.2024.452
  Issue No: Vol. 13, No. 2 (2024)
Retrospective renal sonographic study: assessment of renal volume and
resistance index
- Authors: L.D. Denova, D.D. Ivanov, O.Y. Shukht
  Pages: 116 - 127
  Abstract: Background. Renal ultrasound is a convenient, safe, and affordable tool for visualization of the kidneys in the daily practice of nephrologists and doctors of other specialties. Kidney volume, which is calculated by the sonographic method, gives an idea about the state of the kidneys of the patient, but says almost nothing about their function. There are many studies of renal index of resistance (IR) as a marker of kidney function. IR values were compared with serum creatinine levels and/or histological data. And although conflicting research data limit the use of IR as a marker of kidney function, correct interpretation of IR helps restore it to the status of a candidate marker of kidney function. The purpose of the study: to conduct a retrospective analysis of the sonographic renal parameters in patients who sought outpatient medical care at the Brovary medical institution. Materials and methods. Retrospective randomized cohort study was conducted of sonograms of 66 outpatients who sought outpatient medical care at a private medical facility in Brovary from February 2022 to February 2024. They were divided into 2 groups: the first one (n = 31) — men and the second group (n = 35) — women. Results. The results of multiple linear regression in the group 1 for right kidney (RK) showed that the independent variable in this model, RK thickness, is of low significance as a predictor for IR RK, and the following independent variables were not significant as predictors for IR RK: RK length, RK width, RK volume, age. Multiple linear regression results in the group 1 for left kidney (LK) indicate that the independent variable in this model, LK width, is moderately significant as a predictor for LK IR, and the following independent variables were not significant as predictors for LK IR: LK length, LK thickness, LK volume, age. Multiple linear regression results in the group 2 for RK showed that the independent variables in this model, RK width and age, are significant as predictors for IR RK, and the following independent variables were not significant as predictors for IR RK: RK length, RK thickness, RK volume. Multiple linear regression results in the group 2 for LK indicate that the independent variable in this model, LK width, is moderately significant as a predictor for LK IR, and the following independent variables were not significant as predictors for LK IR: LK length, LK thickness, LK volume, age. Conclusions. Renal ultrasound allows predicting the category of patients who will need a consultation with a nephrologist/urologist, identifying risk groups for chronic kidney disease.
  PubDate: 2024-06-16
  DOI: 10.22141/2307-1257.13.2.2024.453
  Issue No: Vol. 13, No. 2 (2024)
Initial experience of percutaneous nephrolithotomy surgery in secondary
hospital in Bali
- Authors: I Gede Yogi Prema Ananda, Herman Yudawan, I Gusti Lanang Andi Suharibawa
  Pages: 128 - 132
  Abstract: Background. The formation of kidney stones is the result of the accumulation of crystals within the kidneys. Percutaneous nephrolithotomy (PCNL) is the preferred method for treating stones larger than 2 cm. This study aims to analyse outcomes and experiences of PCNL for kidney stone removal. Materials and methods. It was a descriptive study with a cross-sectional design, utilizing secondary data from electronic medical records in Klungkung General Hospital. There are 91 samples collected using total sampling between October 2020 and August 2023. The analysis was conducted using the SPSS Statistics 26. Results. The 51–60 age group (38.5 %) exhibited the highest prevalence of patients undergoing PCNL surgery. The most common type of stone was solitary (48.4 % of cases), with an average size of 3.570 ± 1.159 cm. The mean duration of the procedure was 38.630 ± 21.667 minutes, with a single puncture utilized in 68.1 % of cases. The pain levels experienced were generally low, with a mean score of 2 on a 10-point scale. The mean length of hospital stay was 2.330 ± 1.012 days. The outcomes of PCNL in patients with kidney stones were favourable, with a high stone-free rate of 92.3 % and minimal complications. Рostoperative complications were infrequent. Conclusions. It is suggested that PCNL is an effective and safe procedure for kidney stone removal.
  PubDate: 2024-06-16
  DOI: 10.22141/2307-1257.13.2.2024.454
  Issue No: Vol. 13, No. 2 (2024)
Nephrological care in Ukraine during wartime: challenges and innovations
- Authors: Jabbarli Isa Shadoglan ogli
  Pages: 133 - 139
  Abstract: The war in Ukraine has profoundly impacted the provision of nephrological care, presenting numerous challenges while also driving significant innovations. This study aims to analyze the availability and quality of nephrological care in Ukraine during wartime, focusing on chronic kidney disease stages 1–5D/T. The conflict has caused population displacement, restricted access to treatment, and disrupted healthcare logistics, adversely affecting nephrological care. Despite these challenges, the healthcare community has adapted through the implementation of virtual nephrology, incremental and extended dialysis regimens, and increased use of new therapy approaches. The war led to a decrease in the population and migration of medical personnel, particularly from southeastern to western Ukraine, causing staffing imbalances that were gradually addressed. Technological innovations, such as digital nephrobiopsy with immunohistochemical analysis and the use of cloud-based technology, allowed for rapid and remote diagnosis. Virtual healthcare and remote consultations ensured continuity of care, while kidney transplantation activities saw a notable increase, facilitated by advanced techniques and international aid. Despite initial logistical challenges and resource shortages, the resilience and adaptability of the Ukrainian nephrological care system have been evident. This study underscores the importance of robust contingency planning, international collaboration, and the adoption of innovative solutions to maintain healthcare delivery in conflict zones. The findings offer valuable insights into managing nephrological care under extreme conditions and highlight the potential for these innovations to improve care delivery globally.
  PubDate: 2024-06-16
  DOI: 10.22141/2307-1257.13.2.2024.455
  Issue No: Vol. 13, No. 2 (2024)
KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management
of Chronic Kidney Disease
- Authors: No authors
  Pages: 140 - 171
  Abstract: No abstract
  PubDate: 2024-06-16
  DOI: 10.22141/2307-1257.13.2.2024.456
  Issue No: Vol. 13, No. 2 (2024)
Autologous vein graft in living donor kidney transplant (case report)
- Authors: Parth Bharat Solanki
  Pages: 172 - 174
  Abstract: Renal transplantation is the preferred treatment for end-stage renal disease, with vascular complications being a significant cause of graft dysfunction. Although many surgical methods are used to ensure the most effective possible vascular anastomosis, autologous saphenous vein grafting remains a less explored approach to renal transplantation. Chronic kidney disease often presents with complications related to impaired renal perfusion, necessitating interventions to improve blood flow to the kidneys. Herein, we present a case report detailing the utilization of autologous saphenous grafting to establish an anastomosis between the renal vein and external iliac vein in a patient with сhronic kidney disease with maintenance hemodialysis twice a week. This case report indicates the potential and prospective advantages of using autologous saphenous grafting for intricate renal vein reconstructions in patients with chronic kidney disease.
  PubDate: 2024-06-16
  DOI: 10.22141/2307-1257.13.2.2024.457
  Issue No: Vol. 13, No. 2 (2024)

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