JournalTOCs

Giornale di Clinica Nefrologica e Dialisi
Number of Followers: 0

This is an Open Access Journal

Open Access journal
ISSN (Print) 0394-9362 - ISSN (Online) 1724-5974
Published by AboutScience Srl

[4 journals]

Health Technology Assessment in nephrology and dialysis
- Authors: Stefano Cabula, Elisabetta Frongia, Francesco Burrai, Francesca Mura, Maurizio Marcias
  Pages: 1 - 8
  Abstract: The nephrology and dialysis sector is characterized by a high technological content, considerable technological and digital complexity, continuous innovation within the care processes and a strong economic impact on the national and regional health system. The purpose of this article is to illustrate the application of the Health Technology Assessment (HTA) methodology in the evaluation of technological innovations in the nephrology and dialysis field. In particular, the evaluation steps of the multidimensional and multidisciplinary process applied to the nephrodialysis field will be described, specifically a device to be used in patients with chronic kidney disease, also considering important comorbidities such as cardiomyopathies and arrhythmias, which often require implantation of electronic cardiac implantable devices in renal patients. The HTA uses a rigorous scientific methodology, and today represents an essential tool for a governance of the modern health system, in which every innovative technological element that significantly modifies the organization must be evaluated. For this strategic reason, HTA becomes an important intervention for the dialysis sector, where technological innovations are a fundamental sector. For a precise understanding of the function of HTA in dialysis, a complete example of the application of HTA for the evaluation of a resorbable antibacterial device for the prevention of infections from cardiac implantable electronic devices on patients with high infectious risk has been shown, such as patients with chronic kidney disease.
  PubDate: 2023-02-09
  DOI: 10.33393/gcnd.2023.2509
  Issue No: Vol. 35 (2023)
TikTok e l’informazione sanitaria
- Authors: Giuseppe Quintaliani, Maria Rinaldi Miliani, Claudia Savignani
  Pages: 9 - 12
  Abstract: We explore the utility of social media platforms as educational tools, providing a summary of how these sites are used by the public and demonstrating ways these findings may be applied for educational purposes. Over half of the world’s population utilizes social media platforms. More recently, these platforms have increasingly been used for educational purposes. In the field of health, a large portion of the educational content is coming from users with no formal medical or dermatologic training. In nephrology field there are not TikTok accounts. It would be useful to have an institutional account to provide serious, correct and appropriate information before others spread incorrect information.
  PubDate: 2023-03-23
  DOI: 10.33393/gcnd.2023.2563
  Issue No: Vol. 35 (2023)
Non perdiamo tempo prezioso
- Authors: Franco Bergesio, Anna Maria Ciciani, Marco Lombardi, Gabriele Cerini, Alessandra Petrioli, Giuseppe Curciarello, Monica Pierattelli, Neri Pucci, Alfredo Zuppiroli, Leonardo Mari, Pietro Claudio Dattolo
  Pages: 13 - 15
  PubDate: 2023-03-27
  DOI: 10.33393/gcnd.2023.2578
  Issue No: Vol. 35 (2023)
Una mail
- Authors: Leonardo Mari
  Pages: 16 - 16
  PubDate: 2023-05-03
  DOI: 10.33393/gcnd.2023.2591
  Issue No: Vol. 35 (2023)
Abstracts 41° Congresso Nazionale SIAN ITALIA: Gestione del rischio e
sicurezza delle cure in ambito nefrologico
- Pages: 17 - 21
  Abstract: Final programme
  PubDate: 2023-05-07
  DOI: 10.33393/gcnd.2023.2581
  Issue No: Vol. 35 (2023)
Renal transplant patients: Review of Italian legislation
- Authors: Patrizia Babini, Marco Lombardi, Vito Sparacino, Giuseppe Vanacore
  Pages: 22 - 25
  Abstract: Organ transplantation is a life-saving procedure that can significantly improve the quality of life for patients suffering from organ failure. However, the procurement and transplantation of organs involves complex legal and ethical issues. Italy is not an exception, as the country has faced several challenges related to organ transplantation. The article provides an overview of the regulatory framework governing organ transplantation in Italy, focusing on patients’ needs.
  PubDate: 2023-05-08
  DOI: 10.33393/gcnd.2023.2589
  Issue No: Vol. 35 (2023)
Are human health and environmental health inextricably linked'
- Authors: David Mariani
  Pages: 26 - 28
  Abstract: ONE HEALTH approach, coined by FAO, perfectly sums up a concept that is strongly emerging in the international scientific community. The environment (especially greenery and trees) plays a decisive role in human health and in wellbeing. A change in the development model that takes these issues into account, starting with the design of greener and more sustainable cities, appears necessary and urgent, given that in 2050 approximately 70% of the world’s population will live in large cities.
  PubDate: 2023-05-11
  DOI: 10.33393/gcnd.2023.2594
  Issue No: Vol. 35 (2023)
#insiemePerLaVita
- Authors: Luisa Sternfeld Pavia
  Pages: 29 - 31
  PubDate: 2023-06-30
  DOI: 10.33393/gcnd.2023.2597
  Issue No: Vol. 35 (2023)
Maurizio, Giovanna …e tanto amore!
- Authors: Luisa Sternfeld Pavia
  Pages: 32 - 33
  PubDate: 2023-06-30
  DOI: 10.33393/gcnd.2023.2598
  Issue No: Vol. 35 (2023)
Diffusion-weighted magnetic resonance imaging (DWI) for quantifying cyst
volume and characterizing non-cystic tissue in polycystic kidney disease:
the Mario Negri experience
- Authors: Ariela Benigni
  Pages: 34 - 35
  Abstract: Beyond total kidney and cyst volume, non-cystic tissue plays an important role in autosomal dominant polycystic kidney disease (ADPKD) progression. Recent advancements in magnetic resonance imaging (MRI) offer the possibility to study kidney microstructure and function, beyond anatomy. In particular, Diffusion Weighted Imaging (DWI), a MRI technique sensitive to water molecule motion (diffusion) in biological tissues, allows to investigate microstructure. This study, recently published in the European Radiology scientific journal, proposes and preliminary validates a novel method to segment cystic and non-cystic volume on DWI scans from ADPKD patients. The study also provides evidence of DWI potential in characterizing non-cystic kidney tissue, denoted by higher diffusion and lower perfusion than healthy tissue, in line with its fibrotic nature and the likely presence of microcysts. Overall, this study provides evidence in support of DWI potential in ADPKD. DWI could complement existing biomarkers for noninvasively staging, monitoring, and predicting ADPKD progression and evaluating the impact of novel therapies, possibly targeting damaged non-cystic tissue besides cyst expansion.
  PubDate: 2023-06-30
  DOI: 10.33393/gcnd.2023.2599
  Issue No: Vol. 35 (2023)
#… insiemePerLaVita…#
- Authors: Luisa Sternfeld Pavia
  Pages: 36 - 36
  PubDate: 2023-09-30
  DOI: 10.33393/gcnd.2023.2631
  Issue No: Vol. 35 (2023)
Rete del Ma.Re. 2023… ciak ARPKD: sorelle a confronto
- Authors: Luisa Sternfeld Pavia
  Pages: 37 - 37
  PubDate: 2023-09-30
  DOI: 10.33393/gcnd.2023.2632
  Issue No: Vol. 35 (2023)
The crucial role of the nephrologist in the management of pregnancy in
women with adult autosomal dominant polycystic kidney disease
- Authors: Francesca Tunesi, Liliana Italia De Rosa, Martina Catania, Marta Vespa, Kristiana Kola, Giuseppe Vezzoli, Donatella Spotti, Micaela Petrone, Marco Simonini, Chiara Livia Lanzani, Maria Teresa Sciarrone Aliprandi
  Pages: 38 - 44
  Abstract: Autosomal dominant polycystic kidney disease (ADPKD) is a genetic kidney disease characterized by gradual kidney enlargement and progressive renal function loss. Pregnancy is a significant risk factor for adverse maternal and fetal outcomes in chronic kidney disease (CKD), regardless of the nephropathy. Women with ADPKD often face concerns about worsening their renal condition and passing the disease on to their offspring. Recent studies show better outcomes due to improved pregnancy surveillance and prior counseling. Risk factors for poor fetal and maternal outcomes include advanced maternal age, pre-existing hypertension, urinary infections, proteinuria, and renal failure. Collaboration between nephrologists and gynecologists is essential for addressing clinically significant concerns in pregnant women with ADPKD. Nephrologists should play an active role in assisting and supporting pregnant ADPKD patients as part of a multidisciplinary team.
  PubDate: 2023-09-30
  DOI: 10.33393/gcnd.2023.2628
  Issue No: Vol. 35 (2023)
Renal transplant: gender differences
- Authors: Anna Laura Fantuzzi, Elisa Berri, Lida Tartaglione, Rossella Giannini, Sara Dominjanni , Silvia Porreca
  Pages: 45 - 50
  Abstract: Renal transplantation represents the best treatment for end-stage kidney disease, leading to improved quality of life and life-expectancy for most of the patients. However, gender disparities are evident both in access and in outcomes of kidney transplantation. Women on dialysis are less likely to be on the waiting list for kidney transplantation and to receive an organ from a deceased donor or living donor. Several biological and sociocultural aspects could explain this disparity. On the contrary, more women than men are living kidney donors. Italian women are the first organ donors for living transplants in Europe. The gender difference in living donation is certainly affected by different comorbidities, but such a marked trend highlights a greater predisposition to donate of women, especially in the family context. Some differences are also found in kidney outcomes, even not fully understood. Our paper analyzes the main differences in different aspects of kidney transplantation related to gender, including nutritional aspects.
  PubDate: 2023-08-05
  DOI: 10.33393/gcnd.2023.2606
  Issue No: Vol. 35 (2023)
Gender and sex in the development and progression of renal diseases
- Authors: Marcora Mandreoli
  Pages: 51 - 57
  Abstract: Sex-based disparities in nephrology have been a historically understudied area. In nephrology, gender differences exist with regard to the epidemiology, evolution and prognosis of chronic kidney disease (CKD). In some cases, these differences run contrary to the general population trends. We discuss such gender and sex disparities, including differing impact of traditional and novel risk factors, as well as hormonal factors, all of them potentially influencing propensity, progression and biochemical and psychological aspects of CKD. The factors involved in this gender disparity may include diet, kidney and glomerular size, differences in glomerular hemodynamics, and the direct effects of sex hormones. The progression rate of many renal diseases is affected by sex. In polycystic kidney disease, membranous nephropathy, immunoglobulin A nephropathy, and “chronic renal disease of unknown etiology”, men progress at a faster rate to end-stage renal failure than women do. In many, but not all, animal models of renal disease, estrogens slow progression rate. Animal and experimental studies have tried to offer further mechanistic explanations for gender differences in disease progression. It has been suggested that the gender dimorphism of CKD progression may represent the effects of the interaction of circulating steroids with specific kidney receptors. Endogenous estrogens have in general been considered to have anti-fibrotic and anti-apoptotic effects on the kidney. On the other hand, the faster decline of kidney function in men has been attributed to the specific pro-apoptotic and pro-fibrotic properties of androgens.
  PubDate: 2023-09-26
  DOI: 10.33393/gcnd.2023.2627
  Issue No: Vol. 35 (2023)
The effects of music on anxiety and depression in adult patients
undergoing haemodialysis: a literature review
- Authors: Annalisa Nava, Cristiano Magnaghi, Francesco Burrai, Nadia Pennacchio, Stefania Rinaldi, Elena Brioni
  Pages: 58 - 65
  Abstract: The clinical condition experienced by dialysis patient affects his biopsychosocial functioning, as it alters his life rhythms, personal resources, and emotional ties, creating feelings of uncertainty for the future. This requires a complex process of psychological adaptation which often leads to the manifestation of two important expressions such as anxiety and depression. Music in support of conventional treatments promotes the care of the human being in all its aspects: physical, psychological, emotional, cognitive, social and spiritual as it represents a sort of “escape”, and allows a detachment from reality, albeit momentary. It acts as a regulator of emotions and mood, also creating beneficial effects on hemodynamic parameters such as blood pressure and heart rate. Furthermore, musical stimulations are able to stimulate pleasure by acting directly on the neuroanatomical structures responsible for attention, learning, thinking and behavior. The aim of this literature review is to describe the effect of music on anxiety and depression in patients undergoing haemodialysis in order to propose it as a therapeutic intervention during dialysis treatment.
  PubDate: 2023-10-13
  DOI: 10.33393/gcnd.2023.2655
  Issue No: Vol. 35 (2023)
Sex and gender disparities in lupus nephropathy and kidney transplantation
- Authors: Marcora Mandreoli
  Pages: 66 - 72
  Abstract: Systemic lupus erythematosus (SLE) has a clear prevalence in females. Although there are conflicting data, among males affected by SLE a higher proportion develops lupus nephritis, with a more severe histological and clinical pattern than in females. More frequently males also present an antiphospholipid syndrome. Males are less likely to achieve clinical remission of lupus nephritis. A sex and gender disparity is also present in all the phases preceding the kidney transplant from the referral for eligibility to the registration on the active waiting list. There is a perception among healthcare staff that women have a greater degree of fragility and are therefore less eligible for kidney transplantation. Women also encounter obstacles in completing the tests necessary for inclusion in the waiting list and in many Health Care contexts they are less likely to have a transplant. In the field of living transplantation, women represent over half of all donors, while males are predominantly recipients. Long-term patient and graft survival appears superior in women than in men.
  PubDate: 2023-10-17
  DOI: 10.33393/gcnd.2023.2661
  Issue No: Vol. 35 (2023)
Inibitori del cotrasportatore sodio-glucosio di tipo 2 in pazienti
sottoposti a trapianto renale
- Authors: Aris Tsalouchos
  Pages: 73 - 81
  Abstract: Several recent randomized controlled trials (RCTs) have demonstrated the broad clinical application of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in improving kidney and cardiovascular outcomes in patients with native kidney disease. In January 2023, Dapagliflozin became the first SGLT2 inhibitor approved by the Italian Medicines Agency Administration (AIFA) for the treatment of chronic kidney disease (CKD) regardless of diabetic status. However, although these agents have received considerable praise for their cardiovascular and nephroprotective effects among patients with native kidney disease, the safety and efficacy of SGLT2i in the kidney transplant setting are not well-known as safety concerns have led to the exclusion of transplant recipients from all large RCTs. This review will discuss the known mechanisms SGLT2i employ to provide their beneficial effects, the potential benefits and risks of these agents in the context of kidney transplantation, and finally, it will examine the current findings of published literature on SGLT2i use in kidney transplant recipients and propose potential directions for future research.
  PubDate: 2023-11-23
  DOI: 10.33393/gcnd.2023.2620
  Issue No: Vol. 35 (2023)