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GASTROENTEROLOGY AND HEPATOLOGY (189 journals)                     

Showing 1 - 189 of 189 Journals sorted alphabetically
Abdominal Radiology     Hybrid Journal   (Followers: 22)
ACG Case Reports Journal     Open Access   (Followers: 1)
Acta Endoscopica     Hybrid Journal   (Followers: 1)
Acta Gastroenterologica Latinoamericana     Open Access   (Followers: 2)
Actualités Odonto-Stomatologiques     Open Access   (Followers: 4)
Adipositas - Ursachen, Folgeerkrankungen, Therapie     Hybrid Journal  
Advances in Diabetes and Metabolism     Open Access   (Followers: 30)
Advances in Digestive Medicine     Open Access   (Followers: 15)
Advances in Hepatology     Open Access   (Followers: 3)
AJP Gastrointestinal and Liver Physiology     Hybrid Journal   (Followers: 8)
Akademik Gastroenteroloji Dergisi / Turkish Journal of Academic Gastroenterology     Open Access  
Alimentary Pharmacology & Therapeutics     Hybrid Journal   (Followers: 33)
Alimentary Pharmacology & Therapeutics Symposium Series     Hybrid Journal   (Followers: 2)
American Journal of Gastroenterology Supplements     Full-text available via subscription   (Followers: 7)
American Journal of Gastroenterology, The     Hybrid Journal   (Followers: 177)
Annals of Gastroenterological Surgery     Open Access   (Followers: 1)
Annals of Gastroenterology     Open Access   (Followers: 1)
Arab Journal of Gastroenterology     Full-text available via subscription   (Followers: 3)
Archives of Clinical Gastroenterology     Open Access   (Followers: 2)
Archives of Hepatitis Research     Open Access   (Followers: 2)
Arquivos de Gastroenterologia     Open Access   (Followers: 1)
Australian and New Zealand Continence Journal     Full-text available via subscription   (Followers: 4)
Avances en Odontoestomatologia     Open Access   (Followers: 1)
Best Practice & Research Clinical Gastroenterology     Full-text available via subscription   (Followers: 7)
BMC Gastroenterology     Open Access   (Followers: 15)
BMJ Open Diabetes Research & Care     Open Access   (Followers: 32)
BMJ Open Gastroenterology     Open Access   (Followers: 10)
Canadian Journal of Gastroenterology & Hepatology     Open Access   (Followers: 4)
Case Reports in Gastroenterology     Open Access   (Followers: 4)
Case Reports in Gastrointestinal Medicine     Open Access   (Followers: 3)
Case Reports in Hepatology     Open Access   (Followers: 2)
Cellular and Molecular Gastroenterology and Hepatology     Open Access   (Followers: 4)
Clinical and Experimental Gastroenterology     Open Access  
Clinical and Molecular Hepatology     Open Access   (Followers: 2)
Clinical and Translational Gastroenterology     Open Access   (Followers: 1)
Clinical Diabetes     Full-text available via subscription   (Followers: 44)
Clinical Gastroenterology and Hepatology     Hybrid Journal   (Followers: 33)
Clinical Journal of Gastroenterology     Hybrid Journal   (Followers: 10)
Clinics and Research in Hepatology and Gastroenterology     Hybrid Journal   (Followers: 10)
Clinics and Research in Hepatology and Gastroenterology : X     Open Access   (Followers: 1)
Clinics in Liver Disease     Full-text available via subscription   (Followers: 12)
Colon & Rectum     Hybrid Journal   (Followers: 5)
coloproctology     Hybrid Journal   (Followers: 3)
Colorectal Disease     Hybrid Journal   (Followers: 12)
Comparative Hepatology     Open Access   (Followers: 3)
Current Bladder Dysfunction Reports     Hybrid Journal  
Current Colorectal Cancer Reports     Hybrid Journal   (Followers: 2)
Current Diabetes Reports     Hybrid Journal   (Followers: 30)
Current Gastroenterology Reports     Hybrid Journal   (Followers: 4)
Current Hepatitis Reports     Hybrid Journal   (Followers: 8)
Current Hepatology Reports     Hybrid Journal  
Current Opinion in Gastroenterology     Hybrid Journal   (Followers: 14)
Current Treatment Options in Gastroenterology     Hybrid Journal   (Followers: 6)
Der Gastroenterologe     Hybrid Journal   (Followers: 1)
Diabetes     Full-text available via subscription   (Followers: 575)
Diabetes Internacional     Open Access  
Diabetes Spectrum     Full-text available via subscription   (Followers: 17)
Diagnostic and Therapeutic Endoscopy     Open Access  
Dialysis & Transplantation     Hybrid Journal   (Followers: 6)
Digestion     Full-text available via subscription   (Followers: 4)
Digestive and Liver Disease     Hybrid Journal   (Followers: 15)
Digestive and Liver Disease Supplements     Full-text available via subscription   (Followers: 5)
Digestive Disease Interventions     Hybrid Journal  
Digestive Diseases     Full-text available via subscription   (Followers: 17)
Digestive Diseases and Sciences     Hybrid Journal   (Followers: 5)
Digestive Endoscopy     Hybrid Journal   (Followers: 3)
Diseases of the Colon & Rectum     Hybrid Journal   (Followers: 38)
Diseases of the Esophagus     Hybrid Journal  
Dysphagia     Hybrid Journal   (Followers: 206)
EMC - Técnicas Quirúrgicas - Aparato Digestivo     Full-text available via subscription  
Endoscopia     Open Access  
Endoscopy     Hybrid Journal   (Followers: 10)
Endoscopy International Open     Open Access  
Endoskopie heute     Hybrid Journal   (Followers: 1)
Esophagus     Hybrid Journal  
European Journal of Gastroenterology & Hepatology     Hybrid Journal   (Followers: 23)
Expert Review of Gastroenterology and Hepatology     Full-text available via subscription   (Followers: 9)
Frontline Gastroenterology     Hybrid Journal  
Gastric Cancer     Hybrid Journal   (Followers: 1)
Gastro-News     Full-text available via subscription   (Followers: 3)
Gastroenterologia Kliniczna. Postępy i Standardy     Open Access  
Gastroenterología y Hepatología     Full-text available via subscription  
Gastroenterología y Hepatología (English Edition)     Hybrid Journal  
Gastroenterología y Hepatología Continuada     Full-text available via subscription  
Gastroenterologie up2date     Hybrid Journal   (Followers: 3)
Gastroenterology     Hybrid Journal   (Followers: 242)
Gastroenterology (Gastroenterologìa)     Open Access   (Followers: 2)
Gastroenterology and Hepatology from bed to bench     Open Access   (Followers: 4)
Gastroenterology Clinics of North America     Full-text available via subscription   (Followers: 9)
Gastroenterology Insights     Open Access   (Followers: 2)
Gastroenterology Report     Open Access   (Followers: 2)
Gastroenterology Research     Open Access   (Followers: 6)
Gastroenterology Research and Practice     Open Access   (Followers: 1)
GastroHep     Hybrid Journal   (Followers: 1)
Gastrointestinal Cancer : Targets and Therapy     Open Access   (Followers: 3)
Gastrointestinal Disorders     Open Access  
Gastrointestinal Endoscopy     Hybrid Journal   (Followers: 27)
Gastrointestinal Endoscopy Clinics of North America     Full-text available via subscription   (Followers: 9)
Gastrointestinal Tumors     Open Access  
GE Portuguese Journal of Gastroenterology     Open Access  
Gut     Hybrid Journal   (Followers: 231)
Gut Microbes     Full-text available via subscription   (Followers: 11)
Gut Pathogens     Full-text available via subscription   (Followers: 5)
Hemodialysis International     Hybrid Journal   (Followers: 3)
Hepatic Medicine: Evidence and Research     Open Access   (Followers: 5)
Hepatitis B Annual     Open Access   (Followers: 3)
Hepatitis Monthly     Open Access   (Followers: 4)
Hepatitis Research and Treatment     Open Access   (Followers: 6)
Hepatobiliary & Pancreatic Diseases International     Full-text available via subscription   (Followers: 1)
Hepatology     Hybrid Journal   (Followers: 43)
Hepatology International     Hybrid Journal   (Followers: 7)
Hepatology Research     Hybrid Journal   (Followers: 15)
Hepatology, Medicine and Policy     Open Access  
Hernia     Hybrid Journal   (Followers: 6)
HPB: The official journal of the International Hepato Pancreato Biliary Association     Hybrid Journal   (Followers: 3)
Indian Journal of Gastroenterology     Open Access   (Followers: 1)
Inflammatory Bowel Diseases     Hybrid Journal   (Followers: 45)
Inflammatory Intestinal Diseases     Open Access   (Followers: 1)
Info Diabetologie     Full-text available via subscription   (Followers: 1)
International Journal of Celiac Disease     Open Access   (Followers: 3)
International Journal of Colorectal Disease     Hybrid Journal   (Followers: 10)
International Journal of Hepatology     Open Access   (Followers: 4)
International Journal of Stomatological Research     Open Access  
JGH Open     Open Access   (Followers: 1)
JMIR Diabetes     Open Access  
Journal Africain d'Hépato-Gastroentérologie     Hybrid Journal   (Followers: 1)
Journal für Gastroenterologische und Hepatologische Erkrankungen     Hybrid Journal  
Journal of Clinical Gastroenterology     Hybrid Journal   (Followers: 10)
Journal of Coloproctology     Open Access  
Journal of Crohn's and Colitis     Hybrid Journal   (Followers: 11)
Journal of Crohn's and Colitis Supplements     Full-text available via subscription   (Followers: 2)
Journal of Diabetes Research     Open Access   (Followers: 14)
Journal of Diabetology     Open Access   (Followers: 1)
Journal of Digestive Diseases     Hybrid Journal   (Followers: 2)
Journal of Digestive Endoscopy     Open Access   (Followers: 4)
Journal of Endometriosis and Pelvic Pain Disorders     Hybrid Journal  
Journal of Gastroenterology     Hybrid Journal   (Followers: 11)
Journal of Gastroenterology and Hepatology     Hybrid Journal   (Followers: 13)
Journal of Gastroenterology and Hepatology Research     Open Access   (Followers: 4)
Journal of Gastrointestinal Cancer     Hybrid Journal   (Followers: 3)
Journal of Gastrointestinal Oncology     Open Access   (Followers: 1)
Journal of Hepato-Biliary-Pancreatic Sciences     Hybrid Journal   (Followers: 4)
Journal of Hepatology     Hybrid Journal   (Followers: 24)
Journal of Obesity and Bariatrics     Open Access   (Followers: 1)
Journal of Obesity and Metabolic Research     Open Access   (Followers: 7)
Journal of Social Health and Diabetes     Open Access   (Followers: 2)
Journal of the Anus, Rectum and Colon     Open Access  
Journal of the Canadian Association of Gastroenterology     Open Access  
Journal of Viral Hepatitis     Hybrid Journal   (Followers: 7)
Kidney Disease and Transplantation     Open Access   (Followers: 4)
Kidney International Supplements     Partially Free   (Followers: 4)
Liver Cancer     Open Access   (Followers: 1)
Liver International     Hybrid Journal   (Followers: 12)
Liver Transplantation     Hybrid Journal   (Followers: 9)
Methods in Enzymology     Full-text available via subscription   (Followers: 12)
Nature Reviews Gastroenterology & Hepatology     Full-text available via subscription   (Followers: 38)
Nederlands Tijdschrift voor Diabetologie     Hybrid Journal  
Neurogastroenterology & Motility     Hybrid Journal   (Followers: 2)
Nigerian Journal of Gastroenterology and Hepatology     Full-text available via subscription  
Obesity Science & Practice     Open Access   (Followers: 1)
Oncology, Gastroenterology and Hepatology Reports     Open Access   (Followers: 3)
Open Diabetes Journal     Open Access  
Open Journal of Gastroenterology     Open Access   (Followers: 2)
Pancreatology     Full-text available via subscription   (Followers: 3)
Revista Brasileira de Coloproctologia     Open Access  
Revista de Gastroenterología de México     Open Access  
Revista de Gastroenterología de México (English Edition)     Open Access  
Revista de Gastroenterología del Perú     Open Access  
Revista Española de Enfermedades Digestivas     Open Access  
Revista Estomatológica Herediana     Open Access  
Revista GEN     Open Access  
Revue de Stomatologie et de Chirurgie Maxillo-faciale     Full-text available via subscription   (Followers: 1)
Saudi Journal of Gastroenterology     Open Access   (Followers: 2)
Saudi Journal of Obesity     Open Access   (Followers: 1)
Scandinavian Journal of Gastroenterology     Hybrid Journal   (Followers: 10)
Seminars in Liver Disease     Hybrid Journal   (Followers: 8)
South African Gastroenterology Review     Full-text available via subscription  
Techniques in Coloproctology     Hybrid Journal   (Followers: 11)
Techniques in Gastrointestinal Endoscopy     Hybrid Journal   (Followers: 2)
The Lancet Diabetes and Endocrinology     Full-text available via subscription   (Followers: 222)
Therapeutic Advances in Gastroenterology     Open Access   (Followers: 5)
Therapeutic Advances in Gastrointestinal Endoscopy     Open Access   (Followers: 2)
Türkiye Diyabet ve Obezite Dergisi     Open Access  
United European Gastroenterology Journal     Hybrid Journal   (Followers: 2)
Visceral Medicine     Full-text available via subscription  
Viszeralmedizin     Full-text available via subscription  
World Council of Enterostomal Therapists Journal     Full-text available via subscription  
World Journal of Gastroenterology     Open Access   (Followers: 4)
Zeitschrift für Gastroenterologie     Hybrid Journal   (Followers: 8)


Similar Journals
Journal Cover
Arab Journal of Gastroenterology
Journal Prestige (SJR): 0.395
Citation Impact (citeScore): 1
Number of Followers: 3  
  Full-text available via subscription Subscription journal
ISSN (Print) 1687-1979
Published by Elsevier Homepage  [3203 journals]
  • Virulent Escherichia coli strains among Egyptian patients with acute
           diarrhoea versus urinary tract infection, and their antibiotic
    • Abstract: Publication date: Available online 21 March 2019Source: Arab Journal of GastroenterologyAuthor(s): Nagwa Tharwat, Rasha El-Sherif, Sherif Elnagdy, Raghda Marzaban, Sabah AmerAbstractBackground and study aimsDiarrhoea and urinary tract infection (UTI) are common clinical problems. Meanwhile, Escherichia coli (E. coli), is the commonest bacterial pathogen reported in both of them. This study aimed to evaluate the pathogenic E. coli (PEC) in stool of acute diarrhoea and urine of UTI regarding their virulence genes and their influence on the susceptibility to routinely prescribed antibiotics.Patients and methodsTwenty two stool and another 22 urine samples of patients with acute diarrhoea and UTI respectively were collected from patients admitted at Kasr Al-Ainy Hospital, Faculty of Medicine, Cairo University, Egypt. E. coli isolation, identification of their phyla; chuA, yjaA, and TspE4.C2, and further identification of 10 virulent genes; fimH, papC, papG//, papG///, papEF, afa, sfa, CNF1, iroN & hlyA was performed. Antibiotic susceptibility was studied against quinolones, gentamicin (GM), and trimethoprim-sulphamethoxazole (TMP-SMX).ResultsThe studied virulence genes were comparably detected in both pathogenic samples. In diarrheogenic E. coli (DEC); phylum A was significantly related to both ciprofloxacin (CIP) and TMP-SMX resistance, and both of the virulence genes fimH and iroN were significantly related to all the studied antibiotics resistance, while afa was significantly related to nalidixic acid (NA) resistance. In uropathogenic E. coli (UEC); phylum D was significantly related to CIP and levofloxacin resistance, and both of the virulence genes fimH and iroN were significantly related to most of the studied antibiotics resistance.ConclusionThe isolated PEC was evidently and broadly resistant to the studied antibiotics, with limited influence of their phyla and virulence genes (fimH and iroN).
  • Relationship between lifestyle factors and nutritional status and
           non-alcoholic fatty liver disease among a group of adult Jordanians
    • Abstract: Publication date: Available online 11 March 2019Source: Arab Journal of GastroenterologyAuthor(s): Reema Fayez Tayyem, Hanaa Mahmoud Al-Dayyat, Yaser Mohammed RayyanAbstractBackground and Study AimsNon-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. NAFLD may progress from simple steatosis to nonalcoholic steatohepatitis, cirrhosis and finally decompensated liver failure. This study aims at assessing the relationship between lifestyle factors and nutrients intake and the development of non-alcoholic fatty liver disease (NAFLD) in a group of Jordanian adults 30–60 years of age.Patients and MethodsIn this case-control study, a total of 120 Jordanian adults 30–60 years of age were recruited. Sixty NAFLD patients and 60 control subjects were enrolled. The diagnosis of NAFLD was made based on the basis of ultrasonography. Weight, height and waist circumference (WC) were measured and body mass index (BMI) was calculated. Nutrients intake and physical activity level were assessed using validated questionnaires.ResultsThe results showed that patients with NAFLD had a higher significant difference in BMI, WC, and weight compared to controls (p = 0.001). Physical activity level was significantly higher in control subjects than in cases (p = 0.001). The metabolic parameters were significantly different both groups. The mean daily intakes of macronutrients were significantly higher in cases than in control subjects (p = 0.001). A significant difference was detected in the daily intake of some vitamins and minerals among cases compared to control subjects (p 
  • Lamivudine use in pregnant HBsAg-females effectively reduces maternal
    • Abstract: Publication date: Available online 8 March 2019Source: Arab Journal of GastroenterologyAuthor(s): Hanan M. Foaud, Sahar Maklad, Amany Gmal El Din, Faten MahmoudAbstractBackground and study aimsMother-infant hepatitis B virus (HBV) transmission is the current leading cause of chronic infection. We aimed to assess the efficacy of lamivudine use in hepatitis B surface antigen (HBsAg)-positive pregnant women to decrease viral load and thus aid in the prevention of transmission.Patients and methodsA study of 73 mother-infant pairs. All mono-infected HBsAg-positive pregnant females of any age, who were a candidate for lamivudine during pregnancy were recruited, and a comparison group of HBsAg-positive pregnant females who did not receive any antiviral treatment. All infants received HBV immunoglobulin and vaccine at birth and completed the vaccination schedule and tested after 6 months of age. HBV viral markers and viral load quantitation were performed to all enrolled participants.Results34 (46.6%) females were enrolled in the lamivudine group; 9 (26.5%) received the drug in the last trimester, 25 (73.5%) all through. The comparison group was 39 (53.4%) females; 32 (82.1%) were not candidate for antiviral during pregnancy, and 7 (17.9%) were diagnosed late near delivery. Seventy-one infants tested after full immunization, with their ages ranged between 6.5 and 18 months. Only one infant (1.4%) was positive for HBsAg and HBV DNA in the non-treated group. Maternal viremia near delivery showed a significant reduction in cases that used lamivudine during pregnancy.ConclusionThe use of lamivudine during pregnancy can effectively lower maternal viral load. Timely conducted post-vaccination serological testing is crucial to detect positive cases and immunize susceptible infants.
  • Hydatid disease of the liver with portal vein invasion mimicking portal
           vein thrombosis
    • Abstract: Publication date: Available online 8 March 2019Source: Arab Journal of GastroenterologyAuthor(s): Gulhan Ertan, Sila Ulus, Rukiye Kilicarslan, Mesut Yilmaz, Yahya Paksoy, Cengiz ErolAbstractHydatid cyst disease is a zoonosis caused by the parasite Echinococcus. It may infest any organ of the body, but it most frequently involves the liver, lungs, and nervous system. Portal vein involvement by hydatid cyst disease is extremely rare with only five cases published in the English literature to our knowledge. We present the ultrasonography (US) and computed tomography (CT) findings of a 77-year-old male with hydatid disease of the liver with portal vein invasion mimicking portal vein thrombosis. Colour Doppler US confirmed the lack of blood flow within the portal vein and stigmata of cavernomatosis. CT clearly demonstrated a communication between the multiloculated lesion and the portal vein and the multiple daughter vesicles obstructing the portal vein. The consideration of this complication will make it possible to distinguish this entity from portal vein thrombosis and, thus, the management of the patients with hydatid cyst disease particulary in endemic regions.
  • Managing diabetes and liver disease association: Practice guidelines from
           the Egyptian Association for the Study of Liver and Gastrointestinal
           Disease (EASLGD)
    • Abstract: Publication date: Available online 7 March 2019Source: Arab Journal of GastroenterologyAuthor(s): Abd Elkhalek Hamed, Medhat Elsahar, Nadia M. Elwan, Sarah El-Nakeep, Mervat Naguib, Hanan Hamed Soliman, Ashraf Ahmed Aboubakr, Amany AbdelMaqsod, Heba Sedrak, Samir N. Assaad, Reda Elwakil, Gamal Esmat, Samira Salh, Taymour Mostafa, Sherif Mogawer, Sameh Emil Sadek, Maha M. Saber, Hanan Ezelarab, Asem Ashraf Mahmoud, Souad Sultan
  • Circulating microRNA-155 is associated with insulin resistance in chronic
           hepatitis C patients
    • Abstract: Publication date: Available online 7 March 2019Source: Arab Journal of GastroenterologyAuthor(s): Nourhan M. El Samaloty, Zeinab A. Hassan, Zeinab M. Hefny, Dalia H.A. AbdelazizAbstractBackground and study aimHepatitis C represents a potential public health problem worldwide. Insulin resistance (IR) and type 2 diabetes (T2D) are among the serious metabolic complications for chronic hepatitis C virus (HCV) infection. MicroRNAs (miRNAs) are a group of small non-coding RNAs which are implicated in the modulation of almost all biological processes. The objective of this study was to investigate the levels of both miR-155 and miR-34a in sera of chronic HCV patients with or without T2D.Patients and methodsIn this study, we investigated the expression of both miR-155 and miR-34a in 80 subjects (20 HCV, 19 HCV/T2D, 21 T2D and 19 healthy controls), using quantitative real-time PCR.ResultsOur results revealed significantly higher levels of both miR-155 and miR-34a in chronic HCV patients compared to healthy control subjects. However, only circulating miR-155 levels showed significant decline in diabetic HCV patients compared to non-diabetic HCV group. Intriguingly, the circulating levels of miR-155 were inversely correlated with HOMA-IR, fasting blood glucose and HbA1c levels.ConclusionOur findings indicate that the insulin resistance and T2D in HCV are strongly related to miR-155. This may suggest a role for miR-155 in the pathogenesis of IR caused by HCV. However, further large-scale studies are required to confirm our findings.
  • Postanal minimally invasive surgery “PAMIS” assisted extra-levator
           abdominoperineal excision “ELAPE” for cancer: A novel approach in
           supine position
    • Abstract: Publication date: Available online 12 February 2019Source: Arab Journal of GastroenterologyAuthor(s): Ahmed FaragAbstractLocal recurrences are more common after abdominoperineal excision (APE) than after anterior resection of rectal cancer. Extralevator APE was introduced to address this problem. The post anal minimally invasive approach had been used by other authors for transperineal mesh rectopexy but not in cancer management. Our aim is to use the post-anal minimally invasive approach for better visualization and division of the levator Ani during the Extralevator abdominoprineal excision in 2 cases of carcinoma of the anal canal. After laparoscopic exploration of the abdomen and performing a laparoscopic nerve sparing TME down to the levator ani from the abdominal side, the perineal phase was started by a purse string suture followed by a postanal incision and division of the Anococcygeal ligament, the gel port was inserted where visualization of the levator ani allows its division under vision posteriorly and laterally in order to achieve a good circumferential resection margin in the studied 2 cases. Good circumferential resection margin was reported pathologically and photographed in one of them. Postanal minimally invasive PAMIS assisted technique facilitates the extralevator abdominoperineal “ELAPE” in supine position. However a large multicenter trial comparing this new assisted technique with the traditional ELAPE id needed for a final conclusion.
  • Prognostic factors in patients with active non-variceal upper
           gastrointestinal bleeding
    • Abstract: Publication date: Available online 12 February 2019Source: Arab Journal of GastroenterologyAuthor(s): Ali Akbar Hajiagha Mohammadi, Mohammad Reza AziziAbstractBackground and study aimsAcute upper gastrointestinal bleeding is one of the main causes of hospitalisation. The purpose of this study was to determine the prognostic factors in non-variceal upper gastrointestinal bleeding.Patients and methodsClinical outcomes, demographic and laboratory variables of the subjects were collected from the HIS software and national code with the SQL format from three hospitals in Qazvin. The data were linked to the database software designed by the author. Clinical and upper endoscopic findings of patients’ records were collected through a questionnaire form in the designed software database.ResultsIn this study, 29.2% of patients with favourable outcome and 64.2% of patients with unfavourable clinical outcomes had a history of anticoagulant drug use before hospitalisation (p 
  • Fiducial placement for recurrent gastric cancer
    • Abstract: Publication date: Available online 8 February 2019Source: Arab Journal of GastroenterologyAuthor(s): Mohamed M. Abdelfatah, Eric M. GochanourAbstractA 53-year-old male was diagnosed with invasive adenocarcinoma of the pre-pyloric region. Imaging studies ruled out metastatic disease. The patient underwent neo-adjuvant chemotherapy followed by a partial gastrectomy. CT scan at 18 months’ post-resection demonstrated right upper quadrant lesions suspicious for metastatic disease. EUS exam shows two round hypoechoic lesions. Fine needle aspiration with suction was performed with on-site cytology confirming malignant cells in the masses. Five gold fiducial markers were placed. Final pathology confirmed adenocarcinoma. The patient was subsequently started on stereotactic body radiation therapy (SBRT) with good results. This is the first case report EUS-guided fiducial markers for recurrent gastric cancer post-gastrectomy.
  • Paraoxonase-1 and arylesterase levels in patients with ulcerative colitis
    • Abstract: Publication date: Available online 8 February 2019Source: Arab Journal of GastroenterologyAuthor(s): Memduh Sahin, Onur Bobusoglu, Aylin Yetim, Fehmi AtesAbstractBackground and study aimsThe role of oxidative stress in inflammatory bowel disease is increasingly recognised as an important factor. It is assumed that reduced levels of paraoxonase-1 (PON-1) and arylesterase (ARE) may lead to increased inflammation due to increased oxidative stress. This study aimed to investigate the relationship between ARE and PON-1 levels in ulcerative colitis (UC) patients and the difference in these levels in UC patients in comparison to the control group.Patients and methodsThe study population consisted of 66 (73.3%) UC patients and 24 (26.7%) healthy individuals as the control group. The UC patients and the control group were compared in terms of PON-1 and ARE levels as oxidative stress markers. The UC patients were also grouped according to Mayo UC activity scores, and the differences in their PON-1 and ARE levels were assessed.ResultsThe ARE values were statistically higher in the control group in comparison to the UC patients. Concentrations of PON-1 were not statistically different in the UC and control groups. The ARE value was found to be significantly lower in the UC patients with a haemoglobin level below 10 mg/dl. There was a correlation between the ARE and PON-1 values in the UC patients, but there was no difference between the ARE and PON-1 values, based on the UC patients’ Mayo disease severity scores.ConclusionThis study found that the ARE values of UC patients were lower than those of healthy subjects. The same results could not be determined for PON-1. The data suggest that the antioxidative capacity of UC patients may be reduced.
  • Incomplete cold snare polypectomy for rectal carcinoid tumour
    • Abstract: Publication date: Available online 4 February 2019Source: Arab Journal of GastroenterologyAuthor(s): Yuichiro Hirai, Toshihiro Nishizawa, Toshio Uraoka
  • Colocolic intussusception
    • Abstract: Publication date: Available online 4 February 2019Source: Arab Journal of GastroenterologyAuthor(s): Nadim Mahmud, Kirk J. Wangensteen
  • Metastatic melanoma to the jejunum
    • Abstract: Publication date: Available online 4 February 2019Source: Arab Journal of GastroenterologyAuthor(s): Amer A. Alkhatib
  • Colonization of intestinal microbiota with carbapenemase-producing
           Enterobacteriaceae in paediatric intensive care units in Cairo, Egypt
    • Abstract: Publication date: Available online 4 February 2019Source: Arab Journal of GastroenterologyAuthor(s): Doaa M. Ghaith, Zeinat K. Mohamed, Mohamed G. Farahat, Walaa Aboulkasem Shahin, Hadeel O. MohamedAbstractBackground and study aimsColonized patients with carbapenamase producing Enterobacteriaceae (CPE) are vulnerable to invasive infections from their endogenous flora. We aimed to assess faecal colonization with (CPE) among children admitted to Cairo University paediatric intensive care units (ICUs). The phenotypic and genotypic characterizations of carbapenemase-producing Enterobacteriaceae were also studied.Patients and methodsA total of 413 Enterobacteriaceae isolates have been isolated from cultured rectal swabs of 100 children. All swabs were inoculated on ChromID™ CARBA agar to screen for carbapenem resistant Enterobacteriaceae (CRE). Disk diffusion method, Modified Hodge test (MHT) and further genotypic detection of carbapenemases genes (blaOXA-48, blaKPC and blaNDM-1, blaVIM and blaIMP) by multiplex PCR were done.ResultsOut of 413 Enterobacteriaceae isolates; 100 isolates were defined as CRE. BlaOXA-48 was detected in (33%); Escherichia coli (n = 11), Klebsiella oxytoca (n = 3) and Klebsiella pneumoniae (n = 19), while (27%) carried blaNDM-1 Escherichia coli (n = 7), and Klebsiella pneumoniae (n = 20).ConclusionPrevalence of carbapenem resistant Enterobacteriaceae was 24%, various genes of carbapenemases were detected in 80% of carbapenem resistant Enterobacteriaceae with dominance of blaOXA-48. Understanding the colonization status of our patients with strict infection control measures can reduce the risk of horizontal gene transfer of carbapenemases.
  • Primary omental malignant solitary fibrous tumour, an extremely rare
           malignancy: A case report and review of the literature
    • Abstract: Publication date: Available online 4 February 2019Source: Arab Journal of GastroenterologyAuthor(s): Chang-Yeon Jung, Jung-Min BaeAbstractPrimary omental malignant solitary fibrous tumour is an extremely rare neoplasm considering its tumour origin and pathologic characteristics. Solitary fibrous tumour (SFT) is a spindle cell neoplasm that was first described in 1931. SFT is diagnosed at immunohistochemical stain including CD34, bcl2, CD99 and STAT6. Though most of SFTs are benign in nature, 5–15% are malignant. The diagnostic criteria of malignant SFTs are high cellularity, high mitotic activity(>4/10HPF), pleomorphism, necrosis and haemorrhage.We present the case of a 57-year-old male patient diagnosed with primary omental malignant SFT. Neither tumour origin nor pathologic diagnosis were possible based on preoperative information. Nevertheless, tumour resection was performed successfully.Several SFT cases involving omentum without malignant potential have been reported. However, primary omental malignant SFTs are extremely rare with only 3 cases reported in the literature.
  • Highlights from Gastro Update Europe – Prague, June 2018
    • Abstract: Publication date: December 2018Source: Arab Journal of Gastroenterology, Volume 19, Issue 4Author(s): Guido N.J. Tytgat
  • Characterization of PI3KCA and BRAF mutations in gastric adenocarcinoma:
           An approach to a personalized targeted therapy for Moroccan HER2
           overexpressed patients
    • Abstract: Publication date: December 2018Source: Arab Journal of Gastroenterology, Volume 19, Issue 4Author(s): Hanaa Amrani Hassani Joutei, Nabila Marchoudi, Wafaa Mahfoud, Ilham Sadaoui, Taoufiq Fechtali, Hakima BenomarAbstractBackground and study aimsTargeted therapies have an increasing importance in digestive oncology. To our knowledge, we are the first to report the distribution of PI3KCA and BRAF mutations in Moroccan HER2 overexpressed patients, in order to introduce targeted therapy in the arsenal of therapeutic modalities for management in Morocco.Patients and methods98 gastric adenocarcinoma tissue samples were collected. Further histological and immunohistochemical examinations were carried out at the Laboratory of Anatomy Pathology in Pasteur Institute-Morocco, in order to select HER2 positive cases. Out of 98 cases, 16 were found to be HER2-positive. The molecular study was performed for 55 good quality tissue samples including the HER2-positive ones, and activating mutations in H1047R PI3KCA and V600E BRAF were analyzed by Cast-PCR and Real-time PCR, respectively, at the Department of Molecular Biology, ANOUAL Specialized Center-Casablanca, Morocco. Statistical analyses were performed using the Epi-info software (version 6.09).ResultsPi3KCA mutation was present in 8 cases (14,54%). BRAF mutation was present in 4 cases (7,27%) and 3 cases showed concomitant mutations. In total, 9 cases (16,36%) had PI3KCA and/or BRAF mutations.ConclusionThe association between HER2 expression and PI3KCA alteration in gastric adenocarcinoma is most probably necessary to identify trastuzumab responders. Consequently, the 83,64% rate of HER2-positive patients harboring wild-type mutations possibly represents the portion of patients responding to trastuzumab while the 16,36% rate of patients carrying at least one of the studied mutations represents the portion of potentially non responsive patients to the targeted therapy, and thus may be considered as good candidates for multi-drug targeted therapy.
  • Correlation between expression of MMP-9 and MMP-3 in Helicobacter pylori
           infected patients with different gastroduodenal diseases
    • Abstract: Publication date: December 2018Source: Arab Journal of Gastroenterology, Volume 19, Issue 4Author(s): Nader Bagheri, Marzieh Sadeghiani, Ghorbanali Rahimian, Majid Mahsa, Mohammedhadi Shafigh, Mahmoud Rafieian-kopaei, Hedayatollah ShirzadAbstractBackground and study aimsHelicobacter pylori (H. pylori) has been implicated in the pathogenesis of most important gastro-duodenal diseases, such as gastritis, peptic ulcer disease (PUD) and gastric cancer. H. pylori upregulates the expression and activity of several matrix metalloproteinases (MMPs) in the gastric mucosa, but the role of MMP-3 and MMP-9 in infected patients with H. pylori have not been clearly defined yet. We examined mucosal MMP-3 and MMP-9 mRNA levels in gastric mucosa of H. pylori infected patients and evaluated the effects of virulence factors cagA and vacA allelic variants on these levels. We also determined correlation between mucosal MMP-3 and MMP-9 mRNA levels and types of disease.Patients and methodsTotal RNA was extracted from gastric biopsies of 50 H. pylori-infected patients and 50 H. pylori-negative patients. Mucosal MMP-3 and MMP-9 mRNA expression level in H. pylori-infected and non-infected gastric biopsies were determined by real time-polymerase chain reaction (PCR). Presence of vacA (vacuolating cytotoxin A) and cagA (cytotoxin associated gene A) virulence factors were evaluated using PCR.ResultsThe levels of MMP-3 in gastric mucosa were not different between H. pylori-positive and H. pylori-negative patients. There was no correlation between MMP-3 mRNA expression and virulence factor (cagA and vacA allelic variants) and the different types of disease (gastritis and PUD) in infected patients. But MMP-9 mRNA expression was significantly higher in biopsies of H. pylori-infected patients compared to H. pylori-negative patients. Also mucosal MMP-9 mRNA expression in H. pylori-infected patients was significantly associated with cagA status PUD.ConclusionOur results suggest that MMP-9 might be involved in the pathogenesis of H. pylori. PUD could be associated with cag PAI-dependent MMP-9 upregulation.
  • The association between blood urea nitrogen to creatinine ratio and
           mortality in patients with upper gastrointestinal bleeding
    • Abstract: Publication date: December 2018Source: Arab Journal of Gastroenterology, Volume 19, Issue 4Author(s): Kai-Hsiang Wu, Hsin-An Shih, Ming-Szu Hung, Cheng-Ting Hsiao, Yi-Chuan ChenAbstractBackground and study aimsAzotaemia is commonly identified among patients with upper gastrointestinal bleeding (UGIB) due to absorption of blood products in the small bowel. Previous studies have found blood urea nitrogen-to-creatinine (BUN/Cr) ratio to be significantly elevated among patients UGIB bleeding compared to patients with lower GI bleeding. However, no studies have explored the relationship between BUN/Cr ratio and mortality. This study is aimed at investigating how BUN/Cr ratio relates to outcomes for UGIB patients.Patients and methodsThis study was conducted prospectively at a university-affiliated teaching hospital with approximate 70,000 annual emergency department (ED) visits. Data from a total of 258 adult UGIB patients were collected between March 1, 2011 and March 1, 2012. Cox regression analysis was used to identify risk factors for 30-day mortality.ResultsMalignancy and Rockall score were associated with increased risk of 30-day mortality (Unadjusted hazard ratio (HR): 3.87, 95% CI: 1.59–9.41, p = 0.0029; HR: 1.31, 95% CI: 1.02–1.71, p = 0.0476, respectively). However, BUN/Cr > 30 was associated with lower risk of 30-day mortality (HR: 0.32, 95% CI: 0.11–0.97, p = 0.0441).ConclusionsA BUN/Cr ratio of>30 was found to be an independent risk factor for mortality and may be useful for pre-endoscopic assessment. Development of future risk scoring systems might warrant consideration of including BUN/Cr ratio as a parameter for estimating risk.
  • Giant duodenal Brunner’s gland hamartoma successfully treated via
           endoscopic mucosal resection
    • Abstract: Publication date: September 2018Source: Arab Journal of Gastroenterology, Volume 19, Issue 3Author(s): Yusuke Kitagawa, Hiroki Osumi, Hiroshi Kawachi, Toshiyuki Yoshio, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiaki Hirasawa, Tomohiro Tsuchida, Junko FujisakiAbstractWe describe a patient with a giant Brunner’s gland hamartoma in the duodenum who was safely treated by endoscopic mucosal resection (EMR). A 64-year-old woman visited our hospital for a workup of severe anaemia (haemoglobin level: 5 g/dL). Oesophagogastroduodenoscopy revealed a large pedunculated and elongated polypoid lesion measuring approximately 70 mm in longitudinal diameter, located at the anterior wall of the duodenal bulb. We diagnosed her as having gastrointestinal bleeding originating from this lesion. Although we considered surgical intervention initially, en bloc EMR, a less invasive treatment, was finally accomplished safely by placing endoclips before resection. The histological examination of the specimen revealed a hamartomatous lesion consisting of Brunner’s glands with cystic change and adipose tissue separated by the septa of smooth muscle fibers. Ultimately, we diagnosed her as having Brunner’s gland hamartoma. Notably, there were tiny foci of heterotopic pancreatic tissue containing islets and duct epithelium. Although this type of lesion is benign, a larger one may cause clinical symptoms such as obstruction or bleeding, and thus, local resection is preferable.
  • Tomosynthesis for colonic localization of patency capsules
    • Abstract: Publication date: September 2018Source: Arab Journal of Gastroenterology, Volume 19, Issue 3Author(s): Teppei Omori, Ayumi Ito, Shinichi Nakamura, Katsutoshi Tokushige
  • The gut microbiome and irritable bowel syndrome: State of art review
    • Abstract: Publication date: September 2018Source: Arab Journal of Gastroenterology, Volume 19, Issue 3Author(s): Ahmed E. Salem, Rajdeep Singh, Younan K. Ayoub, Ahmed M. Khairy, Gerard E. MullinAbstractIrritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal tract, the physiology of which is not very well understood. There are multiple factors and pathways involved in pathogenesis of this entity. Among all, dysmotility, dysregulation of the brain-gut axis, altered intestinal microbiota and visceral hypersensitivity play a major role. Over the last years, research has shown that the type of gut microbiome present in an individual plays a significant role in the pathophysiology of IBS. Multiple studies have consistently shown that subjects diagnosed with IBS have disruption in gut microbiota balance. It has been established that host immune system and its interaction with metabolic products of gut microbiota play an important role in the gastrointestinal tract. Therefore, probiotics, prebiotics and antibiotics have shown some promising results in managing IBS symptoms via modulating the interaction between the above. This paper discusses the various factors involved in pathophysiology of IBS, especially gut microbiota.
  • Expression of epidermal growth factor receptor (EGFR) in colorectal
           cancer: An immunohistochemical study
    • Abstract: Publication date: September 2018Source: Arab Journal of Gastroenterology, Volume 19, Issue 3Author(s): Ehsen Ben Brahim, Imen Ayari, Raja Jouini, Salsabil Atafi, Wafa Koubaa, Hela Elloumi, Aschraf ChadliAbstractBackground and study aimThe epidermal growth factor receptor (EGFR) plays an important role in tumourigenesis and tumour progression of colorectal cancer (CRC) and leads to the activation of intracellular signaling pathways. The use of anti-EGFR-targeted therapy has increased for patients with metastatic CRC. Today, the clinical utility of immunohistochemistry has remained somewhat inconclusive. It is based on EGFR screening methods using paraffin-embedded tumour specimen to select patients eligible for treatment. There is still lack of agreement on reproducible scoring criteria for EGFR immunohistochemistry has in various clinical trials.Patients and methodsWe retrospectively reviewed 36 CRC patients who underwent surgeries during 2011 in Habib Thameur hospital in Tunis. We analyzed the immunohistochemical overexpression of EGFR using a score based on immunostaining intensity. In addition, we analyzed the correlation between this overexpression and patients' clinicopathologic parameters.ResultsThe positive expression rate of EGFR was 78% (28/36). Using the immunoreactivity score, 21 cases were considered low grade expression and 15 tumours were high grade. Immunohistochemical expression of EGFR showed a significant difference with tumour’s location (p = 0.034) and vascular invasion (p = 0.03). This expression was not significantly associated with age, gender, tumour size, histological type, grade, TNM staging and perineural invasion.ConclusionsEGFR expression by immunohistochemistry in CRC is variably correlated with clinicopathological parameters. Its assessment by this method has still not proved its predictive value.
  • Evaluation of interleukin 23 (IL-23) as a non-invasive test of disease
           severity in patients with ulcerative colitis
    • Abstract: Publication date: September 2018Source: Arab Journal of Gastroenterology, Volume 19, Issue 3Author(s): Tarek Youssef, Shereen A. Saleh, Angie Rund, Iman Montasser, Manal Mohsen, Ola HazemAbstractBackground and study aimsStudies have found increased expression of IL-23 in inflamed and non-inflamed mucosa of patients with ulcerative colitis (UC). We hypothesized that serum interleukin-23 as a non-invasive test has a role in pathogenesis of ulcerative colitis disease and correlates with the disease severity.Patients and methodsForty patients with biopsy proven ulcerative colitis, recruited from Ain Shams University hospitals were included. Forty healthy subjects matched in age and gender were also included in the study as a control group. Serum IL-23 level was quantified using quantitative ELISA technique (Enzyme linked Immunosorbent Assay).ResultsPatients with UC had higher level of interleukin 23 (234.5 ± 161 pg/mL) compared to control subjects (54.2 ± 15 pg/mL) and the level of IL-23 correlated with the disease severity. Cut off value of IL-23 at 68 pg/mL was the best to differentiate between cases and control subjects. Receiver operating characteristic curve (ROC) revealed that the best cut off for IL-23 to detect mild cases of ulcerative colitis was at105 pg/mL, to detect moderate cases at 200 pg/mL and to detect severe cases was at 270 pg/mL with sensitivity 80% to mild cases, 60% to moderate cases and 81% to severe cases.ConclusionOur findings confirm the suggestion that IL-23 level measurement may be of value as a non-invasive test in the diagnosis and disease severity assessment in patients with UC.
  • Two novel SNPs in the promoter region of PKR gene in hepatitis C patients
           and their impact on disease outcome and response to treatment
    • Abstract: Publication date: September 2018Source: Arab Journal of Gastroenterology, Volume 19, Issue 3Author(s): Dina El-Dahshan, Doaa Bahy, Ahmed Wahid, Amr E. Ahmed, Amro HanoraAbstractBackground and study aimsThe double-stranded RNA dependent protein kinase (PKR) plays a vital role in the immune system. During HCV infection, PKR has antiviral effect by inhibition of protein synthesis of the HCV. The functional single nucleotide polymorphisms (SNPs) in PKR promoter region might have a relation to HCV disease outcome and response to treatment. The objective of the present work was threefold. First, it proposed an optimized protocol for PCR amplification of PKR promoter. Second, it screened the promoter region of PKR gene in HCV Egyptian patients to detect the possible SNPs’ function. Third, to study the association between the detected SNPs and the response to treatment.Patients and methodsThe functional SNPs in PKR promoter region were detected using DNA sequencing in 40 HCV infected patients; 20 sustained virologic response (SVR) patients and 20 nonresponse (NR) patients after combined interferon/ribavirin therapy. Twenty healthy subjects were included as a control.ResultsTwo functional SNPs were detected: rs62133148T>G and rs12992188C>T within our target PKR promoter region. In rs62133148 polymorphism, there is a significant difference between patients and control subjects for TT and TG genotypes (p T). The rs62133148 polymorphism does not show any association with response to treatment. The TT genotype in rs12992188 polymorphism shows association with response to treatment. Therefore, patients with TT genotypes were more likely to achieve SVR.
  • Occult hepatitis C virus infection among haemodialysis patients
    • Abstract: Publication date: September 2018Source: Arab Journal of Gastroenterology, Volume 19, Issue 3Author(s): Naiema K. Ali, Ragaa R. Mohamed, Bothina E. Saleh, Manal M. Alkady, Eman S. FaragAbstractBackground and study aimsHepatitis C virus (HCV) infection is a severe problem among patients on maintenance haemodialysis who are at particular risk for blood-borne infections because of prolonged vascular access and potential for exposure to contaminated equipment. Occult hepatitis C virus infection (OCI) is defined as the presence of HCV RNA in liver or peripheral blood mononuclear cells (PBMCs) in the absence of detectable HCV antibody or HCV RNA in the serum. In this study, we aimed to investigate the existence of occult hepatitis C virus infection in PBMCs of haemodialysis (HD) patients in one center. Moreover, we tried to link the condition to risk factors associated with HCV infection in those patients.Patients and methodsWe included 40 patients with renal diseases undergoing regular haemodialysis who were repeatedly anti-HCV negative. HCV RNA detection was tested by Quantitative Real time PCR in serum and PBMCs.ResultsThe results of this study revealed that 23% of our haemodialysis patients have occult hepatitis C virus infection. There was a highly significant increase in ALT levels in patients with OCI versus the negative group. Also, there is a significant increase of history of blood transfusion in patients with occult HCV (p = 0.03) while the duration of haemodialysis showed no statistical significant difference between both groups. The viral load of the occult hepatitis C virus infection subjects ranged from 581to 74,307 copies/ml.ConclusionThese results highlight the potential risk of hepatitis C virus transmission from patients within haemodialysis units in Egypt. Isolation of patients on dialysis machines depending on the results of hepatitis serological markers is not enough. Testing for hepatitis C virus -RNA in peripheral blood mononuclear cells is more reliable in identifying patients with an OCI when a liver biopsy is not available.
  • Retroperitoneal choriocarcinoma diagnosed by endoscopic
           ultrasonography-guided fine needle aspiration biopsy
    • Abstract: Publication date: September 2018Source: Arab Journal of Gastroenterology, Volume 19, Issue 3Author(s): Hiroyuki Matsubayashi, Ryo Yamashita, Keiko Sasaki, Tomohiro Iwai, Hirotoshi Ishiwatari, Kenichiro Imai, Hiroyuki OnoAbstractA 25-year-old man, with a retroperitoneal bulky mass invading the posterior pancreas head, was referred to investigate and treat his rapidly advancing disease. An endoscopic ultrasonography guided-fine needle aspiration biopsy (EUS-FNAB), performed the next day, and followed by immunostaining for human chorionic gonadotropin (hCG), led to a histological diagnosis of choriocarcinoma. An elevated level of serum hCG also supported the diagnosis. Systemic chemotherapy by etoposide and cisplatin was initiated within a week, with precautions taken to avoid tumour lysis syndrome and choriocarcinoma syndrome. EUS-FNAB enabled a prompt diagnosis and suitable treatment for choriocarcinoma and was considered as an effective diagnostic tool for rare tumours with rapid progression.
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Heriot-Watt University
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