Subjects -> MEDICAL SCIENCES (Total: 8677 journals)
    - ALLERGOLOGY AND IMMUNOLOGY (219 journals)
    - ANAESTHESIOLOGY (120 journals)
    - CARDIOVASCULAR DISEASES (338 journals)
    - CHIROPRACTIC, HOMEOPATHY, OSTEOPATHY (21 journals)
    - COMMUNICABLE DISEASES, EPIDEMIOLOGY (235 journals)
    - DENTISTRY (294 journals)
    - DERMATOLOGY AND VENEREOLOGY (164 journals)
    - EMERGENCY AND INTENSIVE CRITICAL CARE (124 journals)
    - ENDOCRINOLOGY (151 journals)
    - FORENSIC SCIENCES (42 journals)
    - GASTROENTEROLOGY AND HEPATOLOGY (189 journals)
    - GERONTOLOGY AND GERIATRICS (138 journals)
    - HEMATOLOGY (157 journals)
    - HYPNOSIS (4 journals)
    - INTERNAL MEDICINE (177 journals)
    - LABORATORY AND EXPERIMENTAL MEDICINE (99 journals)
    - MEDICAL GENETICS (58 journals)
    - MEDICAL SCIENCES (2410 journals)
    - NURSES AND NURSING (367 journals)
    - OBSTETRICS AND GYNECOLOGY (207 journals)
    - ONCOLOGY (386 journals)
    - OPHTHALMOLOGY AND OPTOMETRY (141 journals)
    - ORTHOPEDICS AND TRAUMATOLOGY (170 journals)
    - OTORHINOLARYNGOLOGY (83 journals)
    - PATHOLOGY (100 journals)
    - PEDIATRICS (275 journals)
    - PHYSICAL MEDICINE AND REHABILITATION (158 journals)
    - PSYCHIATRY AND NEUROLOGY (833 journals)
    - RADIOLOGY AND NUCLEAR MEDICINE (192 journals)
    - RESPIRATORY DISEASES (104 journals)
    - RHEUMATOLOGY (79 journals)
    - SPORTS MEDICINE (81 journals)
    - SURGERY (406 journals)
    - UROLOGY, NEPHROLOGY AND ANDROLOGY (155 journals)

PEDIATRICS (275 journals)                  1 2 | Last

Showing 1 - 200 of 275 Journals sorted alphabetically
AAP Grand Rounds     Full-text available via subscription   (Followers: 20)
Academic Pediatrics     Hybrid Journal   (Followers: 40)
Acta Chirurgica Latviensis     Open Access   (Followers: 4)
Acta Paediatrica     Hybrid Journal   (Followers: 59)
Acta Pediátrica Costarricense     Open Access   (Followers: 1)
Acta Pediátrica de México     Open Access   (Followers: 1)
Acta Pediátrica Española     Full-text available via subscription   (Followers: 1)
Acta Pediátrica Hondureña     Open Access   (Followers: 1)
Acta Pediátrica Portuguesa     Open Access   (Followers: 1)
Adolescent Health, Medicine and Therapeutics     Open Access   (Followers: 9)
Advances in Pediatric Research     Open Access   (Followers: 3)
Advances in Pediatrics     Full-text available via subscription   (Followers: 27)
Alexandria Journal of Pediatrics     Open Access   (Followers: 1)
Ambulatory Pediatrics     Hybrid Journal   (Followers: 5)
American Journal of Perinatology     Hybrid Journal   (Followers: 39)
American Journal of Perinatology Reports     Open Access   (Followers: 18)
Anales de Pediatría     Full-text available via subscription   (Followers: 3)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription  
Annals of Child Neurology     Open Access   (Followers: 1)
Annals of Pediatric Surgery     Open Access   (Followers: 13)
Applied Neuropsychology : Child     Hybrid Journal   (Followers: 28)
APSP Journal of Case Reports     Open Access   (Followers: 5)
Archives of Disease in Childhood     Hybrid Journal   (Followers: 81)
Archives of Disease in Childhood - Education and Practice Edition     Hybrid Journal   (Followers: 22)
Archives of Disease in Childhood - Fetal and Neonatal Edition     Hybrid Journal   (Followers: 73)
Archives of Pediatric Infectious Diseases     Open Access   (Followers: 11)
Archives of Psychiatric Nursing     Hybrid Journal   (Followers: 29)
Archivos de Pediatria del Uruguay     Open Access   (Followers: 3)
Asian Journal of Pediatric Research     Open Access   (Followers: 1)
Assessment and Treatment of Child Psychopathology and Developmental Disabilities     Full-text available via subscription   (Followers: 4)
Bangladesh Journal of Child Health     Open Access  
BDJ Team     Open Access   (Followers: 1)
BMC Pediatrics     Open Access   (Followers: 17)
Boletín de Pediatría     Open Access  
Boletín Médico del Hospital Infantil de México     Open Access  
British Journal of Developmental Psychology     Hybrid Journal   (Followers: 41)
Case Reports in Pediatrics     Open Access   (Followers: 7)
Case Reports in Perinatal Medicine     Hybrid Journal   (Followers: 11)
Child & Family Behavior Therapy     Hybrid Journal   (Followers: 2)
Child Abuse Research in South Africa     Full-text available via subscription   (Followers: 1)
Child and Adolescent Mental Health     Hybrid Journal   (Followers: 67)
Child and Adolescent Psychiatric Clinics of North America     Full-text available via subscription   (Followers: 15)
Child and Adolescent Psychopharmacology News     Full-text available via subscription   (Followers: 2)
Child Care in Practice     Hybrid Journal   (Followers: 7)
Child Development     Hybrid Journal   (Followers: 213)
Child Neurology Open     Open Access   (Followers: 5)
Child Neuropsychology     Hybrid Journal   (Followers: 15)
Child's Health     Open Access  
Child: Care, Health and Development     Hybrid Journal   (Followers: 12)
Children     Open Access   (Followers: 2)
Children Infections     Open Access  
Clinical and Experimental Pediatrics     Open Access   (Followers: 1)
Clinical Medicine Insights : Pediatrics     Open Access   (Followers: 3)
Clinical Pediatric Emergency Medicine     Hybrid Journal   (Followers: 16)
Clinical Pediatrics     Hybrid Journal   (Followers: 22)
Clinical Practice in Pediatric Psychology     Full-text available via subscription   (Followers: 12)
Cognition & Emotion     Hybrid Journal   (Followers: 46)
Comprehensive Child and Adolescent Nursing     Hybrid Journal   (Followers: 5)
Contemporary Pediatrics     Full-text available via subscription   (Followers: 4)
Current Developmental Disorders Reports     Hybrid Journal   (Followers: 3)
Current Opinion in Pediatrics     Hybrid Journal   (Followers: 47)
Current Pediatric Reviews     Hybrid Journal   (Followers: 7)
Current Pediatrics     Open Access   (Followers: 5)
Current Pediatrics Reports     Hybrid Journal   (Followers: 1)
Current Problems in Pediatric and Adolescent Health Care     Full-text available via subscription   (Followers: 4)
Current Treatment Options in Pediatrics     Hybrid Journal   (Followers: 2)
Early Child Development and Care     Hybrid Journal   (Followers: 15)
Early Human Development     Hybrid Journal   (Followers: 13)
Economic and Regional Studies / Studia Ekonomiczne i Regionalne     Open Access  
Egyptian Journal of Pediatric Allergy and Immunology     Open Access   (Followers: 2)
Egyptian Pediatric Association Gazette     Open Access   (Followers: 1)
EL HORMIGUERO Psicoanálisis ◊ Infancia/s y Adolescencia/s     Open Access  
EMC - Pediatría     Full-text available via subscription   (Followers: 1)
Enfance en difficulté     Full-text available via subscription   (Followers: 2)
Enfermería Clínica     Full-text available via subscription   (Followers: 3)
European Archives of Paediatric Dentistry     Hybrid Journal   (Followers: 3)
European Journal of Pediatric Surgery     Hybrid Journal   (Followers: 4)
European Journal of Pediatric Surgery Reports     Open Access   (Followers: 5)
European Journal of Pediatrics     Hybrid Journal   (Followers: 19)
Evidence-Based Child Health: a Cochrane Review Journal     Hybrid Journal   (Followers: 14)
Evidence-Based Practice in Child and Adolescent Mental Health     Hybrid Journal  
Evidencias en Pediatría     Open Access  
Fetal and Pediatric Pathology     Hybrid Journal   (Followers: 4)
First Language     Hybrid Journal   (Followers: 6)
Frontiers in Pediatrics     Open Access   (Followers: 3)
Geriatric Medicine in General Practice     Full-text available via subscription   (Followers: 8)
Global Pediatric Health     Open Access   (Followers: 3)
Indian Journal of Paediatric Dermatology     Open Access   (Followers: 2)
Indian Journal of Pediatrics     Hybrid Journal   (Followers: 9)
Indian Pediatrics     Hybrid Journal   (Followers: 1)
Infancy     Hybrid Journal   (Followers: 6)
Infant Behavior and Development     Hybrid Journal   (Followers: 16)
Infant Mental Health Journal     Hybrid Journal   (Followers: 33)
International Breastfeeding Journal     Open Access   (Followers: 26)
International Journal of Adolescent Medicine and Health     Hybrid Journal   (Followers: 5)
International Journal of Child Development and Mental Health     Open Access   (Followers: 2)
International Journal of Child Health and Nutrition     Hybrid Journal   (Followers: 7)
International Journal of Clinical Pediatrics     Open Access   (Followers: 5)
International Journal of Contemporary Pediatrics     Open Access   (Followers: 6)
International Journal of Pediatric Otorhinolaryngology     Full-text available via subscription   (Followers: 1)
International Journal of Pediatric Otorhinolaryngology Case Reports     Hybrid Journal   (Followers: 1)
International Journal of Pediatric Otorhinolaryngology Extra     Full-text available via subscription   (Followers: 1)
International Journal of Pediatrics     Open Access   (Followers: 4)
International Journal of Pediatrics     Open Access   (Followers: 6)
International Journal of Pediatrics and Adolescent Medicine     Open Access   (Followers: 2)
International Journal of Pedodontic Rehabilitation     Open Access  
Iranian Journal of Child Neurology     Open Access   (Followers: 1)
Iranian Journal of Neonatology     Open Access   (Followers: 5)
Iranian Journal of Pediatric Surgery     Open Access   (Followers: 1)
Iranian Journal of Pediatrics     Open Access   (Followers: 2)
Italian Journal of Pediatrics     Open Access   (Followers: 2)
JAMA Pediatrics     Full-text available via subscription   (Followers: 117)
JMIR Pediatrics and Parenting     Open Access  
Jornal de Pediatria     Open Access   (Followers: 1)
Jornal de Pediatria (Versão em Português)     Full-text available via subscription  
Journal de Pédiatrie et de Puériculture     Full-text available via subscription  
Journal for Specialists In Pediatric Nursing     Hybrid Journal   (Followers: 4)
Journal of Abnormal Child Psychology     Hybrid Journal   (Followers: 11)
Journal of American Association for Pediatric Ophthalmology and Strabismus     Hybrid Journal   (Followers: 8)
Journal of Applied Research on Children     Open Access   (Followers: 4)
Journal of Asthma Allergy Educators     Hybrid Journal   (Followers: 5)
Journal of Autism and Developmental Disorders     Hybrid Journal   (Followers: 91)
Journal of Child & Adolescent Mental Health     Hybrid Journal   (Followers: 15)
Journal of Child and Adolescent Group Therapy     Hybrid Journal   (Followers: 2)
Journal of Child and Adolescent Psychiatric Nursing     Hybrid Journal   (Followers: 5)
Journal of Child and Adolescent Psychopharmacology     Hybrid Journal   (Followers: 5)
Journal of Child Health Care     Hybrid Journal   (Followers: 1)
Journal of Child Science     Open Access  
Journal of Children's Orthopaedics     Open Access   (Followers: 10)
Journal of Clinical Pediatric Dentistry     Full-text available via subscription   (Followers: 6)
Journal of Communication Disorders     Hybrid Journal   (Followers: 18)
Journal of Comprehensive Pediatrics     Open Access   (Followers: 2)
Journal of Developmental & Behavioral Pediatrics     Hybrid Journal   (Followers: 12)
Journal of Early Childhood Research     Hybrid Journal   (Followers: 6)
Journal of Endoscopic and Minimally Invasive Surgery in Newborn, Children and Adolescent     Open Access  
Journal of Fetal Medicine     Hybrid Journal  
Journal of Indian Association of Pediatric Surgeons     Open Access   (Followers: 2)
Journal of Maternal and Child Health     Open Access  
Journal of Memory and Language     Hybrid Journal   (Followers: 44)
Journal of Nepal Paediatric Society     Open Access  
Journal of Neurosurgery: Pediatrics     Full-text available via subscription   (Followers: 11)
Journal of Paediatric Surgeons of Bangladesh     Open Access  
Journal of Paediatrics and Child Health     Hybrid Journal   (Followers: 38)
Journal of Pediatric and Adolescent Gynecology     Full-text available via subscription   (Followers: 3)
Journal of Pediatric and Neonatal Individualized Medicine     Open Access   (Followers: 4)
Journal of Pediatric Biochemistry     Hybrid Journal   (Followers: 1)
Journal of Pediatric Dentistry     Open Access   (Followers: 3)
Journal of Pediatric Endocrinology and Metabolism     Hybrid Journal   (Followers: 29)
Journal of Pediatric Endoscopic Surgery     Hybrid Journal  
Journal of Pediatric Epilepsy     Hybrid Journal   (Followers: 7)
Journal of Pediatric Gastroenterology and Nutrition (JPGN)     Hybrid Journal   (Followers: 49)
Journal of Pediatric Genetics     Hybrid Journal   (Followers: 5)
Journal of Pediatric Health Care     Hybrid Journal   (Followers: 10)
Journal of Pediatric Infectious Diseases     Hybrid Journal   (Followers: 13)
Journal of Pediatric Intensive Care     Hybrid Journal   (Followers: 12)
Journal of Pediatric Nephrology     Open Access   (Followers: 3)
Journal of Pediatric Neuropsychology     Hybrid Journal   (Followers: 7)
Journal of Pediatric Neuroradiology     Hybrid Journal   (Followers: 3)
Journal of Pediatric Neurosciences     Open Access   (Followers: 5)
Journal of Pediatric Nursing     Hybrid Journal   (Followers: 16)
Journal of Pediatric Ophthalmology & Strabismus     Full-text available via subscription   (Followers: 14)
Journal of Pediatric Orthopaedics     Hybrid Journal   (Followers: 14)
Journal of Pediatric Orthopaedics B     Hybrid Journal   (Followers: 5)
Journal of Pediatric Psychology     Hybrid Journal   (Followers: 7)
Journal of Pediatric Surgery     Hybrid Journal   (Followers: 14)
Journal of Pediatric Surgery Case Reports     Open Access   (Followers: 6)
Journal of Pediatric Urology     Hybrid Journal   (Followers: 3)
Journal of Pediatrics     Hybrid Journal   (Followers: 201)
Journal of Pediatrics & Child Care     Open Access   (Followers: 1)
Journal of Pediatrics : X     Open Access   (Followers: 1)
Journal of Perinatal Education     Hybrid Journal   (Followers: 5)
Journal of Perinatal Medicine     Hybrid Journal   (Followers: 12)
Journal of the International Child Neurology Association     Open Access   (Followers: 3)
Journal of the Pediatric Infectious Diseases Society     Hybrid Journal   (Followers: 11)
Journal of Tropical Pediatrics     Hybrid Journal   (Followers: 3)
JuKiP - Ihr Fachmagazin für Gesundheits- und Kinderkrankenpflege     Hybrid Journal   (Followers: 1)
Kinder - und Jugendmedizin     Full-text available via subscription   (Followers: 1)
Kinder- und Jugendmedizin     Hybrid Journal  
La Pediatria Medica e Chirurgica     Open Access  
Maternal and Child Health Journal     Hybrid Journal   (Followers: 19)
MCN : The American Journal of Maternal/Child Nursing     Hybrid Journal   (Followers: 6)
Molecular and Cellular Pediatrics     Open Access  
Monatsschrift Kinderheilkunde     Hybrid Journal  
Music and Medicine     Hybrid Journal   (Followers: 2)
Nascer e Crescer : Birth and Growth Medical Journal     Open Access  
Neonatal Medicine     Open Access   (Followers: 1)
Neonatal, Paediatric & Child Health Nursing     Full-text available via subscription   (Followers: 10)
Neonatologie Scan     Hybrid Journal   (Followers: 1)
NeoReviews     Full-text available via subscription   (Followers: 39)
Neuropediatrics     Hybrid Journal   (Followers: 6)
Nigerian Journal of Paediatrics     Open Access   (Followers: 1)
Open Journal of Pediatrics     Open Access   (Followers: 4)
Open Journal of Pediatrics and Child Health     Open Access   (Followers: 2)
Open Pediatric Medicine Journal     Open Access  
Pädiatrie & Pädologie     Hybrid Journal  
pädiatrie : Kinder- und Jugendmedizin hautnah     Full-text available via subscription   (Followers: 1)
Paediatric Orthopaedics and Related Sciences     Open Access   (Followers: 3)
Paediatric Respiratory Reviews     Hybrid Journal   (Followers: 11)
Paediatrica Indonesiana     Open Access  

        1 2 | Last

Similar Journals
Journal Cover
European Journal of Pediatrics
Journal Prestige (SJR): 0.992
Citation Impact (citeScore): 2
Number of Followers: 19  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1432-1076 - ISSN (Online) 0340-6199
Published by Springer-Verlag Homepage  [2626 journals]
  • Management of pain in newborn circumcision: a systematic review
    • Abstract: Abstract Male circumcision (MC) is one of the most common surgical procedures performed on neonates. In the last decades, there have been consistent advances in the understanding of pain mechanisms in newborns, and analgesia has become a fundamental part of neonatal care. MC is still often performed with inappropriate analgesic methods, and there is still great variability among the various centers about surgical and anesthethic techniques to do it. The purpose of this review is to summarize the findings in the literature about pain management and analgesia during newborn MC. We performed a systematic review of neonatal MC studies published in the last 20 years. The most effective technique appeared to be the combination of pharmacological and non-pharmacological methods of analgesia. Conclusion: Combining local anesthesia with non-pharmacological analgesic strategies appears to be effective preventing procedural pain during MC. However, a standardized protocol for analgesia during MC is yet to be determined. Sensorial saturation appeared to help when used in conjunction with the local anesthesia techniques. What is Known: • Male circumcision is a painful procedure and it is frequently performed with inappropriate analgesic methods. • A gold standard practice in analgesia during male circumcision is still lacking and there is a great variability in the modus operandi between centers. What is New: • The combination of RB + EMLA + sucrose appears to be an analgesic strategy superior to other approaches. • We advocate for the integration of sensorial saturation during male circumcision in order to improve the efficacy of current analgesic practices.
      PubDate: 2020-08-03
       
  • Reduction in minute alveolar ventilation causes hypercapnia in ventilated
           neonates with respiratory distress
    • Abstract: Abstract Hypercapnia occurs in ventilated infants even if tidal volume (VT) and minute ventilation (VE) are maintained. We hypothesised that increased physiological dead space (Vd,phys) caused decreased minute alveolar ventilation (VA; alveolar ventilation (VA) × respiratory rate) in well-ventilated infants with hypercapnia. We investigated the relationship between dead space and partial pressure of carbon dioxide (PaCO2) and assessed VA. Intubated infants (n = 33; mean birth weight, 2257 ± 641 g; mean gestational age, 35.0 ± 3.3 weeks) were enrolled. We performed volumetric capnography (Vcap), and calculated Vd,phys and VA when arterial blood sampling was necessary. PaCO2 was positively correlated with alveolar dead space (Vd,alv) (r = 0.54, p < 0.001) and Vd,phys (r = 0.48, p < 0.001), but not Fowler dead space (r = 0.14, p = 0.12). Normocapnia (82 measurements; 35 mmHg ≤ PaCO2 < 45 mmHg) and hypercapnia groups (57 measurements; 45 mmHg ≤ PaCO2) were classified. The hypercapnia group had higher Vd,phys (median 0.57 (IQR, 0.44–0.67)) than the normocapnia group (median Vd,phys/VT = 0.46 (IQR, 0.37–0.58)], with no difference in VT. The hypercapnia group had lower VA (123 (IQR, 87–166) ml/kg/min) than the normocapnia group (151 (IQR, 115–180) ml/kg/min), with no difference in VE. Conclusion: Reduction of VA in well-ventilated neonates induces hypercapnia, caused by an increase in Vd,phys. What is Known: • Volumetric capnography based on ventilator graphics and capnograms is a useful tool in determining physiological dead space of ventilated infants and investigating the cause of hypercapnia. What is New: • This study adds evidence that reduction in minute alveolar ventilation causes hypercapnia in ventilated neonates.
      PubDate: 2020-08-03
       
  • Correction to: How can primary care practitioners address substance use by
           adolescents' A position paper of the EUROPEAN academy of PAEDIATRICS
    • Abstract: The authors of the published version of this article inadvertently omitted the table note of the Table 2 under the Appendix section. The complete Table 2 is shown in this article]
      PubDate: 2020-08-01
       
  • To mask or not to mask children to overcome COVID-19
    • Abstract: Abstract It has been reported that asymptomatic people can transmit the new coronavirus disease 2019 (COVID-19) and become important sources of COVID-19. To reduce the role of asymptomatic or poorly symptomatic people in COVID-19, universal use of face masks in addition to hand hygiene and safety distance seems extremely useful. Consequently, preparing the healthy child to use face masks is strongly needed. To obtain maximal compliance, reasons for mask wearing without attempts of removing must be clearly explained. Moreover, child’s will must not be forced. Conclusion: On the basis of clinical findings, we think that the universal use of facial masks seems necessary when people have to go out in their everyday lives. In addition to the availability of masks of different sizes capable of adapting perfectly to the face, it is necessary that the use of masks in children is preceded by a strong parental work and school lessons on this issue and other hygiene topics with the main aim to obtain child cooperation. What is Known: • Asymptomatic people can transmit and become important sources of COVID-19. • Asymptomatic cases are common also in pediatrics. What is New: • Universal use of face masks for success against COVID-19 seems necessary also in pediatric age when people have to go out in their everyday lives. • In addition to the availability of masks of different sizes capable of adapting perfectly to the face, it is necessary that the use of masks in children is preceded by a strong parental work and school lessons with the main aim to obtain child cooperation.
      PubDate: 2020-08-01
       
  • Reply to correspondence letter by Dr Sivanandan S and Dr Thukral A
    • PubDate: 2020-08-01
       
  • COVID-19 in children: patiently and critically evaluate the scientific
           evidence
    • PubDate: 2020-08-01
       
  • A safe flight for children through COVID-19 disaster: keeping our mind
           open!
    • PubDate: 2020-08-01
       
  • Mask-wearing in pediatric age
    • PubDate: 2020-08-01
       
  • Re: Esposito et al.: To mask or not to mask children to overcome COVID-19
    • PubDate: 2020-08-01
       
  • Letter to the Editor on the original article “Efficacy of double versus
           single phototherapy in treatment of neonatal jaundice: a meta-analysis”
           by MA Nizam et al
    • PubDate: 2020-08-01
       
  • Less invasive surfactant administration: all that glitters is not gold
    • PubDate: 2020-08-01
       
  • “How can a drug to treat claudication in adults save preterm
           newborns'”
    • PubDate: 2020-08-01
       
  • Primum non nocere: lingual frenotomy for breastfeeding problems, not as
           innocent as generally accepted
    • Abstract: Abstract The frenotomy or surgical release of the lingual frenulum is performed with increasing frequency. Restricted tongue mobility, ankyloglossia, is the main indication for this procedure. This clinical diagnosis is often used as synonym for tongue-tie which is blamed for many feeding difficulties resulting in an increase in performed frenotomies. Until recently, little was known about the anatomical structure and normal variation of the tongue-tie. Different grading systems have been developed. Some are exclusively based on appearance of the tongue-tie; others also include functional elements. There is, however, no established relation between the tongue-tie score and the observed feeding problems or outcomes following frenotomy. Therefore, caution is warranted before submitting babies to this procedure. Conclusion: This narrative review aims to give an overview of current knowledge and concerns regarding the tongue-tie, which need to be considered before referral for a frenotomy. What is Known: • The presence of a tongue-tie is associated with a higher frequency of breastfeeding problems. • Hence, frenotomy is advocated and increasingly performed in infants with breastfeeding problems. Current tongue-tie classifications do not allow to predict breastfeeding problems. What is New: • New anatomy insights caution for possible complications resulting from this seemingly innocent practice of frenotomy. • Frenotomy should only be performed after multidisciplinary evaluation of feeding problems, following exclusion and remediation of other causative factors.
      PubDate: 2020-08-01
       
  • Predictors for place of death among children:A systematic review and
           meta-analyses of recent literature
    • Abstract: Abstract Through a systematic review and meta-analyses, we aimed to determine predictors for place of death among children. We searched online databases for studies published between 2008 and 2019 comprising original quantitative data on predictors for place of death among children. Data regarding study design, population characteristics and results were extracted from each study. Meta-analyses were conducted using generic inverse variance method with random effects. Fourteen cohort studies met the inclusion criteria, comprising data on 106,788 decedents. Proportions of home death varied between countries and regions from 7% to 45%. Lower age was associated with higher odds of hospital death in eight studies (meta-analysis was not possible). Children categorised as non-white were less likely to die at home compared to white (pooled OR 0.6; 95% CI 0.5–0.7) as were children of low socio-economic position versus high (pooled OR 0.7; 95% CI 0.6–0.9). Compared to patients with cancer, children with non-cancer diagnoses had lower odds of home death (pooled OR 0.5; 95% CI 0.5–0.5). Conclusion: Country and region of residence, older age of the child, high socio-economic position, ‘white’ ethnicity and cancer diagnoses appear to be independent predictors of home death among children. What is Known: • Home is often considered an indicator of quality in end-of-life care. • Most terminally ill children die in hospitals. What is New: • Through a systematic review and meta-analyses, this study examined predictors for place of death among children. • Country and region of residence, older age of the child, high socio-economic position, white ethnicity and having a cancer diagnosis appear to be independent predictors of home death among terminally ill children.
      PubDate: 2020-08-01
       
  • Comorbidities in childhood associated with extrauterine growth restriction
           in preterm infants: a scoping review
    • Abstract: Abstract Extrauterine growth restriction (EUGR) is a frequent morbidity of preterm infants that can affect short- and long-term prognosis as it involves different EUGR-related alterations in growth and neurological development, as well as cardiometabolic risk. However, knowledge about the prognosis of EUGR is scarce. Thus, the objective of this study is to review the evidence regarding EUGR-related comorbidities in childhood by a systematic approach. This review was carried out using the Joanna Briggs Institute Reviewers’ Manual Methodology and the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses)-Search Extension for scoping review. The MEDLINE and EMBASE databases were used to identify papers published until September 2017. Twenty-four publications were included and 19 examined cohort studies. EUGR is mainly associated with (1) lower weight, length, and head circumference measures in childhood; (2) poor neurodevelopment; and (3) alterations in cardiometabolic risk markers. The definition for EUGR and the populations studied differ among authors. Conclusion: EUGR is mainly associated with poor growth and neurodevelopment, as well as with cardiometabolic alterations in childhood. Evidence is based on observational studies with variability in the included populations due to the lack of consensus regarding the definition for EUGR. Finding a gold standard definition becomes paramount in order to select phenotypes at risk later in life. What is known' • EUGR is a frequent condition of preterm infants. Up to date little is known about the effect of the metabolic programming on prognosis. What is new' • The available evidence, which is based on observational studies with variability in the population and the existing different definitions for EUGR, do not enable appropriate data collection. EUGR is mainly associated with poor growth and neurodevelopment, as well as with cardiometabolic alterations in childhood.
      PubDate: 2020-08-01
       
  • Low-risk trials for children and pregnant women threatened by unnecessary
           strict regulations. Does the coming EU Clinical Trial Regulation offer a
           solution'
    • Abstract: Abstract Investigator-initiated clinical trials are crucial for improving quality of care for children and pregnant women as they are often excluded from industry-initiated trials. However, trials have become increasingly time-consuming and costly since the EU Clinical Trial Directive entered into force in 2001. This directive made compliance with ICH-Good Clinical Practice Guidelines (ethical and quality standard for conducting human subject research) mandatory for all clinical trials, regardless of its risk-classification. By discussing two investigator-initiated, ‘low-risk’ drug trials, we aim to illustrate that compliance with all GCP requirements makes trials very laborious and expensive, while a clear rationale is missing. This discourages clinical researchers to start and carry out investigator-initiated research. However, the forthcoming EU Clinical Trial Regulation (No 536/2014) seems to provide a solution as it allows for less stringent rules for low-risk trials. We want to raise awareness for these developments in both the clinical research community and the European and national regulatory authorities. Implementation of this forthcoming Regulation regulatory policies should be done in such a way that investigator-initiated trials evaluating standard care interventions will become more feasible. This will allow us to obtain evidence on optimal and safe treatments, especially for groups that are underrepresented in medical research. What is Known • Investigator-initiated trials are indispensable for improving care for children and pregnant women as they are often excluded from industry-initiated trials • Trials have become increasingly time-consuming and costly because of mandatory compliance with ICH-GCP guidelines What is New • The forthcoming EU Clinical Trial Regulation allows less stringent rules for low-risk trials • The national legislator and regulatory authorities should recognize the importance of this opportunity and implement the Regulation in such a way that investigator-initiated trials will become more feasible
      PubDate: 2020-08-01
       
  • Minimally invasive surfactant therapy versus InSurE in preterm neonates of
           28 to 34 weeks with respiratory distress syndrome on non-invasive positive
           pressure ventilation—a randomized controlled trial
    • Abstract: Abstract Preterm neonates with respiratory distress syndrome (RDS) are commonly treated with surfactant by intubate surfactant extubate (InSurE) technique. Mode of surfactant administration has evolved towards less invasive technique in the last few years. We randomised 58 preterm infants of 28–34 weeks of gestation with RDS within 6 h of birth to receive surfactant by InSurE or minimally invasive surfactant therapy (MIST). Non-invasive positive pressure ventilation (NIPPV) was used as primary respiratory support. The main objective was to compare the need of invasive mechanical ventilation (IMV) in first 72 h of life and secondarily hemodynamically significant patent ductus arteriosus (hsPDA), intraventricular haemorrhage (IVH) (> grade 2), bronchopulmonary dysplasia (BPD) and composite outcome of BPD/mortality. We did not find any difference in need of IMV in first 72 h between MIST and InSurE (relative risk with MIST, 0.62; 95% confidence interval, 0.22 to 1.32). No difference was observed in terms of hs PDA, IVH (> grade 2), BPD and composite outcome of BPD/mortality. Conclusion: There is no difference between MIST and InSurE in preterm neonates with RDS with NIPPV as a primary mode of respiratory support. Larger multicentre studies are needed to further explore differences in treatment failure and other secondary outcomes. Trial registration: www.ctri.nic.in id CTRI/2019/03/017992, registration date March 8, 2019. What is Known • InSurE is commonly used for many years for treatment of RDS in preterm neonates. • MIST has been introduced as a newer tool. What is New • MIST with feeding tube is comparable with InSurE in preterm infants with RDS in developing countries. •NIPPV can be used as primary respiratory support for MIST.
      PubDate: 2020-08-01
       
  • Point-of-care lung ultrasound in three neonates with COVID-19
    • Abstract: Abstract Since March 2020, the world is involved in the COVID-19 pandemic, a disease caused by a novel virus called SARS-CoV-2. Some authors have described the ultrasonographic findings of COVID-19 pneumonia in adults and children, but data on neonates are lacking. Our objective was to describe the ultrasonographic lung pattern on newborns with SARS-CoV-2 infection during the COVID-19 pandemic. Newborns who tested positive for SARS-CoV-2 PCR in respiratory samples and were evaluated with point-of-care lung ultrasound (LU) from March to April 2020 were included. LU was performed bedside by a single investigator at the time of diagnosis and every 48 h during the first week following diagnosis. Six areas were studied. Three neonates were included. Infants’ comorbidities included meconium aspiration syndrome, bronchopulmonary dysplasia, and Hirschsprung’s disease. One required mechanical ventilation. No deaths occurred. LU showed B-lines, consolidation, and spared areas. No pneumothorax or pleural effusion was observed Conclusions: LU could be of value when managing COVID-19 neonates. We describe the findings of lung ultrasound monitoring during the first week following diagnosis in three neonates with SARS-CoV-2 infection. What is known: • Lung ultrasound (LU) is a useful tool in COVID-19 management in adults. To date, no report on LU and neonates with SARS-CoV-2 infection has been published. What is new: • This study adds evidence about LU findings in neonates with SARS-CoV-2 infection.
      PubDate: 2020-08-01
       
  • Pseudomonas aeruginosa bloodstream infections in children: a 9-year
           retrospective study
    • Abstract: Abstract P. aeruginosa bloodstream infection (BSI) is associated with high hospital mortality. Empirical combination therapy is commonly used, but its benefit remains debated. The purpose of this study was to describe in a paediatric population, demographical characteristics and outcome of children treated for P. aeruginosa BSI receiving either a combined or single antibacterial therapy. We performed a retrospective, single-centre, cohort study of hospitalized children with P. aeruginosa BSI from 2007 to 2015. A total of 118 bloodstream infections (BSI) were analysed (102 (86.4%) hospital-acquired, including 52 (44.1%) hospitalized in intensive care unit). In immunocompromised children, 52% of BSI episodes were recorded. Recent medical history revealed that 68% were hospitalized, 31% underwent surgery and 67% had a prior antibiotic therapy within the last 3 months. In-hospital mortality was similar for patients receiving single or combined anti-Pseudomonas therapy (p = 0.78). In multivariate analysis, independent risk factors for in-hospital mortality were neutropenia (OR = 6.23 [1.94–20.01], hospitalization in ICU (OR = 5.24 [2.04–13.49]) and urinary tract infection (OR = 4.40 [1.02–19.25]). Conclusion: P. aeruginosa BSI mainly occurred in immunocompromised children. Most infections were hospital-acquired and associated with high mortality. Combination therapy did not improve survival. What is Known: • P. aeruginosa bloodstream infection (BSI) is associated with high hospital mortality. Empirical combination therapy is commonly used but its benefit remains debated. What is New: • This is the largest cohort of Pseudomonas aeruginosa bacteraemia in children ever published. P. aeruginosa Bloodstream mainly occurred in immunocompromised children. Most infections were hospital-acquired and associated with high mortality. Combination therapy did not improve survival.
      PubDate: 2020-08-01
       
  • Effect of ondansetron on vomiting associated with acute gastroenteritis in
           a developing country: a meta-analysis
    • Abstract: Abstract In high-income countries. ondansetron is an effective antiemetic in children with gastroenteritis, but data from low- and middle-income countries are sparse. This study aimed to evaluate evidences of the effectiveness of ondansetron in preventing vomiting and reducing the use of intravenous fluids in children with gastroenteritis in developing countries. A total of nine randomized controlled trials (RCTs) involving 2313 participants met the inclusion criteria. Compared with placebo, ondansetron reduced the use of intravenous rehydration (three RCTs, n = 1126, relative risk (RR) 0.60, 95% confidence interval (CI) 0.38–0.95, no significant heterogeneity, I2 = 43%), the risk of failure of oral rehydration therapy among children with gastroenteritis-associated vomiting and dehydration (four RCTs, n = 1370, RR 0.58, 95% CI 0.43–0.79; no significant heterogeneity was found, I2 = 39%) and risk of hospitalization (2 RCTs, n = 264, RR 0.25, 95% CI 0.09–0.73, no heterogeneity, I2 = 0). Conclusions: Compared with placebo, ondansetron reduced the use of intravenous fluids in children with gastroenteritis and dehydration. It has no effect on children with gastroenteritis who do not present with dehydration in developing countries. While ondansetron is effective in controlling vomiting and reducing the rate of hospitalization, there is no evidence that it is effective in reducing the rate of readmission. What is Known: • In high-income countries, ondansetron can reduce the use of intravenous fluids in children with gastroenteritis and dehydration. • No systematic review and meta-analysis of randomized controlled trials were done in a developing country setting. What is New: • In developing countries, ondansetron reduces the use of intravenous fluids in children with gastroenteritis and dehydration. • It has no effect on children with gastroenteritis but without dehydration.
      PubDate: 2020-08-01
       
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
 


Your IP address: 3.226.245.48
 
Home (Search)
API
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-