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ENDOCRINOLOGY (149 journals)                     

Showing 1 - 134 of 134 Journals sorted alphabetically
AACE Clinical Case Reports     Hybrid Journal   (Followers: 5)
Acta Diabetologica     Hybrid Journal   (Followers: 17)
Adipositas - Ursachen, Folgeerkrankungen, Therapie     Hybrid Journal   (Followers: 1)
Advances in Chronic Kidney Disease     Hybrid Journal   (Followers: 15)
Advances in Diabetes and Metabolism     Open Access   (Followers: 22)
Advances in Endocrinology     Open Access   (Followers: 7)
AJP Endocrinology and Metabolism     Hybrid Journal   (Followers: 25)
American Journal of Kidney Diseases     Hybrid Journal   (Followers: 53)
Annales d'Endocrinologie     Hybrid Journal   (Followers: 2)
Applied Physiology, Nutrition and Metabolism     Hybrid Journal   (Followers: 37)
Best Practice & Research Clinical Endocrinology & Metabolism     Hybrid Journal   (Followers: 15)
BMC Endocrine Disorders     Open Access   (Followers: 8)
Case Reports in Endocrinology     Open Access   (Followers: 3)
Clinical Diabetes     Full-text available via subscription   (Followers: 40)
Clinical Diabetes and Endocrinology     Open Access   (Followers: 20)
Clinical Endocrinology     Hybrid Journal   (Followers: 42)
Clinical Medicine Insights : Endocrinology and Diabetes     Open Access   (Followers: 29)
Clinical Nutrition Insight     Full-text available via subscription   (Followers: 13)
Clinical Reviews in Bone and Mineral Metabolism     Hybrid Journal  
Comprehensive Psychoneuroendocrinology     Open Access  
Current Opinion in Endocrine and Metabolic Research     Hybrid Journal   (Followers: 1)
Current Opinion in Endocrinology, Diabetes and Obesity     Hybrid Journal   (Followers: 48)
Dermato-Endocrinology     Open Access   (Followers: 3)
Diabesity     Open Access   (Followers: 3)
Diabetes & Metabolic Syndrome: Clinical Research & Reviews     Hybrid Journal   (Followers: 27)
Diabetes & Metabolism     Hybrid Journal   (Followers: 72)
Diabetes, Obesity and Metabolism     Hybrid Journal   (Followers: 261)
Diabetes/Metabolism Research and Reviews     Hybrid Journal   (Followers: 63)
Diabetology & Metabolic Syndrome     Open Access   (Followers: 8)
Discover Oncology     Open Access   (Followers: 1)
Domestic Animal Endocrinology     Hybrid Journal   (Followers: 6)
Dubai Diabetes and Endocrinology Journal     Open Access  
Egyptian Journal of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Endocrine     Hybrid Journal   (Followers: 11)
Endocrine and Metabolic Science     Open Access   (Followers: 1)
Endocrine Connections     Open Access   (Followers: 4)
Endocrine Disruptors     Open Access  
Endocrine Journal     Open Access   (Followers: 13)
Endocrine Pathology     Hybrid Journal   (Followers: 7)
Endocrine Practice     Hybrid Journal   (Followers: 58)
Endocrine Regulations     Open Access  
Endocrine Research     Hybrid Journal   (Followers: 3)
Endocrine Reviews     Full-text available via subscription   (Followers: 44)
Endocrine, Metabolic & Immune Disorders - Drug Targets     Hybrid Journal   (Followers: 1)
Endocrine-Related Cancer     Full-text available via subscription   (Followers: 2)
Endocrinología, Diabetes y Nutrición (English Edition)     Hybrid Journal   (Followers: 2)
Endocrinology     Full-text available via subscription   (Followers: 50)
Endocrinology and Metabolism Clinics of North America     Full-text available via subscription   (Followers: 28)
Endocrinology, Diabetes & Metabolism     Open Access  
Endocrinology, Diabetes & Metabolism Case Reports     Open Access  
Endocrinology, Obesity and Metabolic Disorders     Full-text available via subscription   (Followers: 6)
Endokrynologia Polska     Open Access   (Followers: 2)
European Journal of Endocrinology     Full-text available via subscription   (Followers: 40)
European Thyroid Journal     Full-text available via subscription   (Followers: 3)
Experimental and Clinical Endocrinology & Diabetes     Hybrid Journal   (Followers: 24)
Experimental and Clinical Endocrinology & Diabetes Reports     Open Access   (Followers: 4)
Expert Opinion on Drug Metabolism & Toxicology     Hybrid Journal   (Followers: 15)
Expert Review of Endocrinology & Metabolism     Hybrid Journal   (Followers: 7)
Frontiers in Clinical Diabetes and Healthcare     Open Access  
Frontiers in Endocrinology     Open Access   (Followers: 5)
Frontiers in Neuroendocrine Science     Open Access  
Frontiers in Neuroendocrinology     Hybrid Journal   (Followers: 10)
General and Comparative Endocrinology     Hybrid Journal   (Followers: 5)
Growth Hormone & IGF Research     Hybrid Journal   (Followers: 14)
Gynakologische Endokrinologie     Hybrid Journal  
Gynecological Endocrinology     Hybrid Journal   (Followers: 5)
Hormone and Metabolic Research     Hybrid Journal   (Followers: 16)
Hormone Research in Paediatrics     Full-text available via subscription   (Followers: 16)
Hormones : International Journal of Endocrinology and Metabolism     Hybrid Journal  
Hormones and Behavior     Hybrid Journal   (Followers: 12)
Indian Journal of Endocrinology and Metabolism     Open Access   (Followers: 4)
International Journal of Clinical Endocrinology and Metabolism     Open Access   (Followers: 1)
International journal of endocrine oncology     Open Access  
International Journal of Endocrinology     Open Access   (Followers: 3)
International Journal of Endocrinology     Open Access   (Followers: 1)
International Journal of Endocrinology and Metabolism     Open Access   (Followers: 3)
International Journal of Obesity     Hybrid Journal   (Followers: 90)
International Journal of Osteoporosis and Metabolic Disorders     Open Access   (Followers: 1)
International Journal of Pediatric Endocrinology     Open Access   (Followers: 11)
JIMD Reports     Open Access  
Journal für Gynäkologische Endokrinologie/Österreich     Hybrid Journal  
Journal für Klinische Endokrinologie und Stoffwechsel : Austrian Journal of Clinical Endocrinology and Metabolism     Hybrid Journal  
Journal of Bone and Mineral Metabolism     Hybrid Journal   (Followers: 5)
Journal of Clinical and Translational Endocrinology     Open Access  
Journal of Clinical and Translational Endocrinology Case Reports     Open Access   (Followers: 2)
Journal of Clinical Endocrinology & Metabolism     Full-text available via subscription   (Followers: 139)
Journal of Developmental Origins of Health and Disease     Hybrid Journal   (Followers: 2)
Journal of Diabetes and Endocrinology     Open Access   (Followers: 7)
Journal of Diabetes and Endocrinology Assocation of Nepal     Open Access  
Journal of Diabetes and Metabolic Disorders     Open Access   (Followers: 8)
Journal of Diabetes Science and Technology     Hybrid Journal   (Followers: 13)
Journal of Diabetology     Open Access   (Followers: 1)
Journal of Endocrinological Investigation     Full-text available via subscription   (Followers: 7)
Journal of Endocrinology     Full-text available via subscription   (Followers: 13)
Journal of Endocrinology and Metabolism     Open Access   (Followers: 5)
Journal of Endocrinology and Reproduction     Hybrid Journal  
Journal of Endocrinology, Metabolism and Diabetes of South Africa     Open Access   (Followers: 8)
Journal of Inborn Errors of Metabolism and Screening     Open Access  
Journal of Molecular Endocrinology     Full-text available via subscription   (Followers: 5)
Journal of Neuroendocrinology     Hybrid Journal   (Followers: 8)
Journal of Pineal Research     Hybrid Journal   (Followers: 1)
Journal of Renal and Hepatic Disorders     Open Access  
Journal of Restorative Medicine     Open Access  
Journal of Social Health and Diabetes     Open Access   (Followers: 1)
Journal of the ASEAN Federation of Endocrine Societies     Open Access  
Kidney International     Hybrid Journal   (Followers: 52)
Kidney Research Journal     Open Access   (Followers: 6)
L'Endocrinologo     Hybrid Journal  
Metabolic Brain Disease     Hybrid Journal   (Followers: 1)
Metabolic Syndrome and Related Disorders     Hybrid Journal   (Followers: 5)
Metabolism     Hybrid Journal   (Followers: 11)
Molecular and Cellular Endocrinology     Hybrid Journal   (Followers: 8)
Molecular Metabolism     Open Access   (Followers: 9)
Nature Reviews Endocrinology     Full-text available via subscription   (Followers: 60)
Neuroendocrinology     Full-text available via subscription   (Followers: 8)
Nigerian Endocrine Practice     Full-text available via subscription  
Nutrition in Clinical Practice     Hybrid Journal   (Followers: 43)
Open Journal of Endocrine and Metabolic Diseases     Open Access   (Followers: 1)
Psychoneuroendocrinology     Hybrid Journal   (Followers: 15)
Reproductive Biology and Endocrinology     Open Access   (Followers: 3)
Reproductive Endocrinology     Open Access   (Followers: 1)
Reviews in Endocrine and Metabolic Disorders     Hybrid Journal   (Followers: 2)
Revista Argentina de Endocrinología y Metabolismo     Open Access  
Revista Cubana de Endocrinología     Open Access  
Revista Venezolana de Endocrinología y Metabolismo     Open Access  
Sri Lanka Journal of Diabetes Endocrinology and Metabolism     Open Access  
The Endocrinologist     Full-text available via subscription   (Followers: 6)
The Lancet Diabetes and Endocrinology     Full-text available via subscription   (Followers: 167)
Therapeutic Advances in Endocrinology and Metabolism     Open Access   (Followers: 5)
Thyroid     Hybrid Journal   (Followers: 11)
Thyroid Research     Open Access   (Followers: 3)
Thyroid Research and Practice     Open Access   (Followers: 3)
Trends in Endocrinology & Metabolism     Full-text available via subscription   (Followers: 19)
Vitamins & Hormones     Full-text available via subscription   (Followers: 1)


Similar Journals
Journal Cover
Reproductive Endocrinology
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2309-4117 - ISSN (Online) 2411-1295
Published by Trilist Publishing Homepage  [1 journal]
  • Uterine fibroids: synthesis of modern knowledge

    • Authors: K.D. Plaksiieva, T.F. Tatarchuk, N.V. Kosei, K.Y. Melnyk, O.S. Kozlov
      Pages: 8 - 18
      Abstract: Uterine fibroids is an extremely common tumor of the female reproductive system in the population. The problem of this pathology is the diversity of symptoms, mediated by the variety of sizes and locations of myomas, significant impact on reproductive function and frequent misunderstanding of the tumor nature, which leads to unwarranted hysterectomies, even among young women.
      Authors review the literature on the basis of modern guidelines, which reveals the potential of preserving methods of treatment of fibroids. It is also attempted to answer the most common questions about this pathology.
      The incidence of uterine fibroids increases with age. Fibroids are hormone dependent tumors, but the obvious cause has not yet been identified, although various risk factors are known, both modified (e.g., obesity, parity) and unmodified (race, age, etc.). Diagnosis of fibroids is simple – just an examination and ultrasound of the pelvis. Among the organ preservation methods of treatment are currently known medicinal (some of them can be used as mono-method or in combination with other methods), minimally invasive (among which stands out uterine artery embolization, as the most studied, effective and safe method) and surgical – conservative myomectomy, which can be performed by different approaches (laparoscopic, hysteroscopic or laparotomy) depending on the number and location of fibroids.
      This review considers the issues of fertility in uterine fibroids and after organ preservation technologies for its treatment. Differential diagnosis of uterine fibroids with leiomyosarcoma – a rare tumor and its diagnosis is quite difficult.
      The development of modern medical science, combining specialties with the formation of multidisciplinary teams (as in the case of collaboration with endovascular surgeons to perform uterine artery embolization) and use of an individual approach depending on the fibroids characteristics and patient needs helps reduce the proportion of hysterectomies for uterine fibroids, preservation of the organ and fertility.
      PubDate: 2022-05-27
      DOI: 10.18370/2309-4117.2022.63.8-18
  • Treatment of testosterone deficiency syndrome in obese men with type 2

    • Authors: Y.V. Luchytskyi, H.A. Zubkova, V.M. Rybalchenko, V.Y. Luchytskyi, I.I. Skladanna
      Pages: 19 - 22
      Abstract: Objective: to study the effect of testosterone replacement therapy and aromatase inhibitors on the state of androgen supply in men with type 2 diabetes mellitus (DM-2) with obesity.
      Materials and methods. We examined 38 men aged 37 to 62 years with DM-2 and obesity (main group) and 82 practically healthy men (control group). Blood concentration of luteinizing hormone (LH), total testosterone (Ttot), estradiol (E2) was determined by enzyme immunoassay. T concentration below 8.0 nmol/l was regarded as a sign of hypogonadism, the criterion for hyperestrogenemia was an increase of E2 level over 46 pg/ml. The criterion for obesity was a body mass index > 30 kg/m2.
      Results. The average serum level of Ttot was significantly reduced compared to the control group. The average levels of E2 in patients of the main group did not differ from the control group. Determination of the average LH levels in the main group showed no probable difference compared to the same indicators in the control group. The Ttot/E2 ratio was lower in men with DM-2 and obesity, but this difference did not reach statistical significance. The Ttot/LH coefficient, which characterizes the effect of endogenous LH on the androgen-producing function of the testicles, was significantly decreased in the main group compared to the control group.
      Testosterone replacement therapy significantly increased (p < 0.05) the mean blood levels of T. The average E2 levels increased in the dynamics of this therapy, but did not go beyond the normal range for adult men. Letrozole 1.25 mg 1 time per day every other day for 3 months had a positive effect. The E2 levels decreased from 30 to 60%, which was accompanied by an increase of the T concentration by 1.5–6.5 times compared with the baseline levels.
      Conclusions. DM-2 and obesity are factors in the development of testosterone deficiency syndrome in men. A promising area for research is the use of aromatase inhibitors in men with DM-2, obesity, and testosterone deficiency syndrome caused by hyperestrogenemia.
      PubDate: 2022-05-27
      DOI: 10.18370/2309-4117.2022.63.19-22
  • Practical approaches to the use of markers of biochemical hyperandrogenism
           in women

    • Authors: T.M. Tutchenko, O.A. Burka, I.V. Sidorova, I.H. Nohovska, I.M. Marynchyna, N.M. Shcherbatiei
      Pages: 25 - 33
      Abstract: Hyperandrogenism (HA) remains an actual problem that raises a large number of questions, in particular, in cases of discrepancy between the clinical signs of HA and biochemical parameters. This review includes an analysis of recent studies of androgen synthesis and metabolism in healthy women of reproductive age; management of pathologies accompanied by HA; as well as contemporary approaches to the principles of prescribing and evaluating the results of the main available markers of biochemical HA.
      There are сoncepts of clinical and biochemical HA. Biochemical HA is an increase in the levels of various circulating androgens. The concept of clinical HA includes hirsutism as assessed by the modified Ferriman–Gallwey scale. The most common causes of HA include polycystic ovary syndrome, non-classical forms of congenital adrenal hyperplasia, other endocrine disorders. It is necessary to carry out a differential diagnosis of these conditions with more rare causes as a primarily tumor pathology. The choice and evaluation of laboratory markers of biochemical HA should be made taking into account clinical data such as puberty history, anovulation, polycystic ovarian morphotype, obesity; presence and degree of hirsutism and/or other androgen-associated dermatopathies, the characteristics of the course of clinical HA (sudden onset, rapid progression), presence of other endocrinopathies, liver and kidney dysfunction; diabetes mellitus.
      The objectives of the laboratory assessment of HA are determination of HA severity; determination of the source of excess androgen synthesis (ovaries, adrenal glands); assessment of the free fraction of circulating active androgens; in some cases, assessment of the formation of active androgens in the skin. The following indicators are used to solve the tasks in laboratory diagnostics: total testosterone, free testosterone, free androgen index, androstenedione, dehydroepiandrosterone sulfate, 17-hydroxyprogesterone, dihydrotestosterone. A comprehensive assessment of these indicators allows not only assessing the presence of HA and its severity, but also the nature of its leading and secondary components, which determine the presence and prognosis of metabolic risks and allow individualizing therapeutic approaches.
      PubDate: 2022-05-27
      DOI: 10.18370/2309-4117.2022.63.25-33
  • An interaction between growth hormone/insulin-like growth factor-1 and
           vitamin D in children with short stature

    • Authors: O.V. Bolshova, N.A. Sprynchuk, D.A. Kvacheniuk, N.M. Muz, M.O. Ryznychuk, I.V. Lukashuk, T.M. Malinovska, O.Y. Samson, O.A. Vyshnevska, V.H. Pakhomova
      Pages: 34 - 38
      Abstract: There are disorders in the growth hormone (GH)/growth factors system in a significant part of patients with short stature; first of all, this concerns such diseases as growth hormone deficiency, where there is a sharp decrease in GH, insulin-like growth factor-1 (IGF-1). The association between vitamin D and GH/growth factor system remains unclear. It was found that vitamin D is able to increase IGF-1 level in healthy individuals. Linear growth is accelerated after treatment of vitamin D deficiency in children, which may indicate the linking role of vitamin D between the proliferative cells of the growth plate cartilage and GH/growth factor system.
      Research objective: to determine 25-hydroxyvitamin D level in blood plasma in children with short stature, depending on the state of GH/IGF-1 system.
      Materials and methods. Study included 101 children with short stature: 33 children with partial somatotropic insufficiency (group 1); 44 children with complete somatotropic insufficiency (group 2); 24 children with syndrome of biologically inactive GH (group 3). Patients in groups 1 and 2 had a confirmed GH deficiency and a decrease or sharp decrease in of IGF-1 level; patients in group 3 had a normal stimulated release of GH against the background of a reduced IGF-1 level. GH, IGF-1, 25-hydroxyvitamin D, thyroid-stimulating hormone, and free thyroxine were determined in all children.
      Results. The average level of vitamin D in three groups corresponded to the vitamin deficiency according to international standards and was 52.24 ± 5.99 nmol/l in patients with partial somatotropic insufficiency, 67.6 ± 5.35 nmol/l in patients with complete somatotropic insufficiency and 58, ± 7.91 nmol/l in patients with syndrome of biologically inactive GH. A direct correlation was found between vitamin D and background GH level, stimulated GH level in children with both partial and complete somatotropic insufficiency. A direct correlation between vitamin D and IGF-1 level in this group of patients was also detected.
      Conclusions. It is advisable to determine the serum 25(OH)D in all children with short stature. Vitamin D levels should be taken into account in insulin/clonidine diagnostic tests in order to obtain a realistic indication of stimulated GH and IGF-1 levels.
      PubDate: 2022-05-27
      DOI: 10.18370/2309-4117.2022.63.34-38
  • Primary aldosteronism and pregnancy

    • Authors: V.I. Medved, M.Y. Kyrylchuk, A.Y. Husieva
      Pages: 39 - 46
      Abstract: The article is devoted to a review of scientific publications that study primary aldosteronism (PA), as well as its features during pregnancy. PA is the most common cause of secondary hypertension. There are few data on PA during pregnancy. PA is characterized by excessive production of aldosterone, which leads to hemodynamic changes in the body, especially the appearance of hypertension. Studies in recent years have shown that up to 88% of adenomas may have gene mutations involved in the regulation of aldosterone synthesis: KCNJ5, CACNA1D, ATP1A1, ATP2B3 and CTNNB1. PA is a renin-independent hypersecretion of aldosterone, which remains an underdiagnosed cause of hypertension. Early diagnosis and treatment contribute to the favorable course of this disease.
      Changes in renin-angiotensin-aldosterone activity during pregnancy may delay diagnosis. The risk of combined preeclampsia in patients diagnosed with PA may be even higher than in women with chronic primary hypertension with an estimated risk of approximately 17–25%. Given the lack of treatment standards, the management of pregnancies described in scientific publications is different.
      However, given current knowledge, the following recommendations are possible:
      • pregnancy should be programmed, and PA should be monitored as much as possible without the use of spironolactone before pregnancy;
      • adrenalectomy should be performed if unilateral adrenal damage is found before pregnancy;
      • antihypertensive drugs approved for use during pregnancy, such as methyldopa, β-blockers, should be used during pregnancy planning;
      • spironolactone should be discontinued before conception.
      It can be used a diuretic that was prescribed before pregnancy, or prescribed the diuretic in a situation of uncontrolled hypertension.
      The article also presents our own clinical case of three pregnancies in one woman with PA, their course and outcome. Only the first pregnancy was complicated by preeclampsia, and PA was diagnosed 5 years after the first birth. All pregnancies ended with the birth of living, full-term babies.
      PubDate: 2022-05-27
      DOI: 10.18370/2309-4117.2022.63.39-46
  • Preserving reproductive health before the first pregnancy

    • Authors: О.V. Kravchenko
      Pages: 47 - 52
      Abstract: Research objective: to evaluate the effectiveness of drugs based on decamethoxine for the treatment of inflammatory diseases of genital organs in adolescent girls entering reproductive age.
      Materials and methods. The study included 96 patients aged 17–19 years who lived an irregular sexual life. The diagnosis of vulvovaginal infection was verified based on clinical and laboratory data. All patients with vulvovaginal infection received Decasan solution 50–100 ml three times a day in the form of irrigation of the external genitalia for the daytime sanitation and Gynodek vaginal gel 5 ml once at night for 7 days, which provided a night exposure of the antiseptic component and created an environment for the restoration of vaginal lactoflora. The effectiveness of treatment was assessed by the results of clinical and bacteriological examination before and after treatment. The criteria for the effectiveness of treatment were complete clinical and bacterial sanitation.
      Results. According to the results of the microbiological study, all patients were divided into 3 groups: group I consisted of 36 patients with nonspecific vulvovaginitis, group II – 28 adolescent girls with vulvovaginal candidiasis, group III – 32 patients with mixed bacterial-candidiasis infection.
      The clinical efficacy of therapy was 95.8%: in group I – 94.4%, in group II – 96.4%, in group III – 96.9%. Bacteriological examination, carried out 2 weeks after the end of the course of treatment, confirmed the effectiveness of therapy in 94.4% of adolescent girls with nonspecific vulvovaginitis, in 89.3% with vulvovaginal candidiasis and in 87.5% with mixed bacterial-candidiasis infection.
      Conclusions. Topical treatment of inflammatory genital diseases in adolescent girls entering reproductive age is effective, safe and can be considered the therapy of choice. Therapy with drugs based on decamethoxine (Decasan and Gynodek) is highly effective in mono- and mixed vulvovaginal infections, which contributes to the preservation of the reproductive health of adolescent girls at the stage of entering reproductive age.
      PubDate: 2022-05-27
      DOI: 10.18370/2309-4117.2022.63.47-52
  • Assessment of the fetoplacental complex and hemostasis system status in
           perinatal care of pregnant women with fetal congenital malformations

    • Authors: D.M. Shchurko, M.I. Shchurko, N.M. Rozhkovska, S.P. Posokhova, V.O. Sytnikova
      Pages: 53 - 58
      Abstract: Research objective: to assess the morpho-functional status of the fetoplacental complex and hemostasis system in pregnant women with congenital malformations in the fetus to prevent antenatal fetal death and determine further tactics of management and delivery.
      Materials and methods. The state of fetoplacental circulation was studied in 120 pregnant women with fetal congenital malformations in the third trimester by Doppler assessment of blood flow in the umbilical artery (UA) and middle cerebral artery (MCA) in the fetus, with resistance index, pulse index and maximum systolic and terminal diastolic velocities ratio. The functional activity of the hemostasis system was assessed by low-frequency piezoelectric thromboelastography. Morphological examination of the placenta was performed. The control group included 25 pregnant women without fetal congenital malformations.
      Results. In case of Doppler flow disturbances in UA and combination of these disturbances with hypercoagulability, the probability of antenatal fetal death if there were congenital malformations ranged from 2–3 to 7–14 days (r = 0.51 and r = 0.55, respectively). A high risk of antenatal fetal death occurred with blood flow disorders in the UA and MCA (r = 0.70), as well as with blood flow disorders in the UA in combination with hypercoagulation and inhibition of fibrinolysis (r = 0.78). The highest risk of antenatal death occurred in case of impaired blood flow in the MCA with hypercoagulation and inhibition of fibrinolysis (r = +0.99).
      An urgent delivery within a day is indicated when there are blood flow disorders in the UA or MCA, combined with hypercoagulation and inhibition of fibrinolysis. The respiratory distress syndrome is treated by administering a surfactant at gestational ages up to 34 weeks. Delivery within 2–3 days is indicated in case of impaired blood flow in the UA and hypercoagulation, this allows preventing of respiratory distress syndrome with corticosteroids if the gestational age is less than 34 weeks.
      Conclusions. In pregnant women with fetal congenital malformations, significant disturbances in blood flow in the UA (increased resistance index and maximum systolic and final diastolic velocities ratio) and decreased pulse index in the MCA were revealed, which indicates intrauterine hypoxia and centralization of blood flow. The functional activity of the hemostasis system was characterized by an increase in the blood coagulation potential in the vascular-platelet, a coagulation unit, which was accompanied by morphological and functional changes in the placenta in response to hypoxia.
      Implementation of the proposed algorithm for perinatal support of pregnant women with fetal congenital malformations and placental dysfunction helps to optimize pregnancy management and delivery, reduce perinatal morbidity and mortality.
      PubDate: 2022-05-27
      DOI: 10.18370/2309-4117.2022.63.53-58
  • The first experience of reproductive function restoration in patients with
           Asherman’s syndrome using autologous mesenchymal stem cells

    • Authors: M.I. Kozub, S.M. Hramatiuk, M.M. Kozub, M.P. Sokol, L.I. Hyrman, O.V. Knihavko, L.M. Savelieva
      Pages: 59 - 66
      Abstract: The main goal of Asherman’s syndrome treatment is to restore the volume and shape of the uterine cavity, regenerate the endometrium and reproductive function. Recently, in addition to ultrasound diagnostics of intrauterine synechiae, office hysteroscopy is widely used. The most standardized stages of Asherman’s syndrome treatment are hysteroscopic dissection of the uterine cavity synechiae and endometrium re-adhesion prevention in the postoperative period, which is achieved by the introduction of the intrauterine device, anti-adhesive drugs or balloon catheters inserted intrauterinely.
      The main difficulties are to find effective ways to prevent adhesion that occurs after removal of mechanical means from the uterine cavity and ways to restore the endometrium morphology in patients wishing to achieve pregnancy. The most promising technique in this area is the use of autologous endometrial stem cells.
      Here is a case of treatment of a reproductive age patient with infertility and Asherman’s syndrome. The clinical case was a part of a clinical trial Clinical Identifier: NCT04675970. On the eve of the operative stage for uterine cavity synechiae separation 20.0 ml of venous blood was taken. Mesenchymal stem cells (MSCs) were isolated from the patient’s peripheral blood using the magnetic separation method of the autoMACS Pro Separator (Miltenyi Biotec). According to the international instructions, 6th passage MSCs were clinically used. Confirmation of belonging the derived cells to the MSCs group was performed using the set Bio-Techne FMC-020 (Great Britain). In addition, MSCs were differentiated to endometrial cells, which was confirmed using endometrial cell matching markers in generations P0-P3 (passage 0 – passage 3) with the MicroBead Kit (USA).
      The operative stage of treatment included office hysteroscopy, mechanical synechiolysis in the endocervix and endometrium and introduction of a silver-containing intrauterine device. Subendometrial injection of autologous endometrial MSCs was performed to restore the endometrium structure at the end of hysteroscopy. High dose adjuvant estrogen therapy followed for 3 weeks. Pregnancy was achieved spontaneously 2 years after the intervention. The patient gave birth to a full-term baby girl.
      The results of the clinical case indicate the prospects for the use of autologous blood stem cells converted into endometrial cells in the treatment of infertility in patients with CA in the absence of effect from previous attempts to restore fertility by traditional therapies.
      PubDate: 2022-05-27
      DOI: 10.18370/2309-4117.2022.63.59-66
  • Prenatal ultrasound diagnostics of atrioventricular communication in
           combination with the tetralogy of Fallot in a fetus with Down's
           syndrome phenotype

    • Authors: M.P. Veropotvelian, A.O. Bondarenko, О.V. Shashko, T.V. Usenko, D.I. Lailo
      Pages: 67 - 71
      Abstract: This article presents a description of our own case of ultrasound prenatal diagnostics of complex combined heart disease (complete atrioventricular communication in combination with tetralogy of Fallot) at 19–20 weeks of gestation with ultrasound markers of Down's syndrome in fetus. Pregnancy termination was performed at 21 weeks. Prenatal diagnosis was fully confirmed at the fetus autopsy.
      This publication discusses the frequency, mechanism of occurrence of such a combination of congenital heart defects, prenatal management, methods, timing and efficiency of surgical correction after birth. Complete atrioventricular communication occurs in approximately 1.7–2% patients with tetralogy of Fallot, and tetralogy of Fallot occurs in 5–10% of patients with atrioventricular communication, most often in patients with Down's syndrome. It is believed that tetralogy of Fallot and a complete defect of the atrioventricular septum develop as a result of different mechanisms, but their joint occurrence
      is recognized as an association. The prevalence of such a combination in Down syndrome indicates the general foundations of its development.
      Sonographic diagnosis of atrioventricular communication and tetralogy of Fallot is usually not difficult for prenatal screening. Main diagnostic criteria for complete atrioventricular communication at routine ultrasound screening and targeted fetal echocardiography are an abnormal 4-chamber image of the heart in the form of a common atrioventricular junction and a common five-leafed atrioventricular valve. Typical prenatal sonographic signs of the tetralogy of Fallot are a high defect of the interventricular septum, expansion of the aortic root, displacement of the aorta forward and to the right, narrowing of the pulmonary artery at the level of the valve ring from minor to complete atresia, it is also possible reduction the size of the right ventricle and increasing the size of the left ventricle.
      The combination of atrioventricular communication with the tetralogy of Fallot refers to severe congenital heart defects requiring surgical correction.
      PubDate: 2022-05-27
      DOI: 10.18370/2309-4117.2022.63.67-71
  • Features of biochemical parameters and non-specific resistance factors of
           vaginal contents in women with urogenital trichomoniasis and cervical
           intraepithelial neoplasia against the background of papillomavirus

    • Authors: O.A. Dyndar, V.O. Beniuk, T.V. Kovaliuk, T.R. Nykoniuk, O.S. Neymark
      Pages: 73 - 84
      Abstract: Research objective: to improve the effectiveness of diagnosis and prognosis of complications in women of reproductive age with atypical squamous cells of undetermined significance/cervical intraepithelial neoplasia (ASCUS/CIN) of the cervix in Trichomonas and papillomavirus infection by studying the main biochemical and immunological parameters of vaginal contents.
      Materials and methods. 200 women of reproductive age with ASCUS/CIN of the cervix were examined against the background of papillomavirus infection associated with trichomoniasis, who were divided into three main groups according to the results of the PAP-test. Group I consisted of 50 patients with ASCUS, II – 118 women with LSiL, III – 32 patients with HSiL. The control group included 50 healthy non-pregnant women. The analysis of biochemical parameters of vaginal contents was carried out, which included determining the concentration of total protein, urea, studying mineral and lipid metabolism, glucose, enzyme activity, as well as factors of non-specific resistance – secretory immunoglobulin A and hydrogen peroxide.
      Results. There was a 2.6-fold increase in the amount of discharge from the genital tract and their pathological nature in patients with urogenital trichomoniasis and ASCUS/CIN against the background of papillomavirus infection, an increase in acidity by 1.2 times, the indicator of the amine test by 13 times, protein concentration by 2.3 times, compared with similar indicators in healthy women. Analysis of mineral metabolism in this contingent of patients revealed a decrease in the concentration of copper ions by 1.7 times, iron by 1.9 times, and calcium by 1.6 times. Evaluation of the enzyme activity revealed an increase in the level of alkaline phosphatase by 3.7 times, creatine phosphokinase by 10.6 times, AST by 6.5 times, ALT by 9.1 times, lactate dehydrogenase by 5.4 times, and α-amylase by 3.3 times compared to women in the control group. A decrease in the average value of sІgA content in patients with ASCUS/CIN on the background of HPV and Trichomonas invasion was found than in healthy women by 1.7, 1.9 and 2 times, respectively, in the I, II and III main groups, which can serve as a predictor of the development of post-trichomonas vaginal dysbiosis.
      Conclusions. Analysis of the results of studies of vaginal contents in women with ASCUS/CIN against the background of human papillomavirus and Trichomonas invasion revealed significant changes in biochemical parameters and factors of non-specific resistance, determining the corresponding pathological changes in the functional activity of the vaginal epithelium and the composition of the vaginal biotope.
      PubDate: 2022-05-27
      DOI: 10.18370/2309-4117.2022.63.73-84
  • Influence of conditioned media from glial cell cultures on contractility
           of uterine in rats of different ages

    • Authors: H.V. Nesteruk, N.M. Alabedalkarim, N.A. Komaromi, N.О. Tkachenko, O.S. Protsenko, Y.I. Lehach
      Pages: 85 - 90
      Abstract: Background. The physiological regulation of the uterine contractile activity changes with age, which leads to an increased number of prolonged labor and emergency caesarean sections in women giving birth at the age of 35+. One of the modern approaches to correct the function of the reproductive system is the use of from cell cultures. CM from glial cell culture contains neurotrophic factors that play an important role in maintaining the contractile function of the uterus. Current cell culture technologies include cryopreservation.
      Objective: to research experimentally the effect of CM obtained from intact and cryopreserved cultures of glial cells on the contractile activity of the uterus in rats of different reproductive ages.
      Materials and methods. The monolayer cell culture was obtained from the dorsal root ganglia of neonatal piglets and cryopreserved in the presence of cryoprotectant dimethyl sulfoxide. CM from native and cryopreserved cultures were collected for 28 days, after which fractions with a molecular weight of < 30 kDa were obtained from them by ultrafiltration. Rats at the age of 6 and 14 months, which corresponds to reproductive age and late reproductive age (LRA), were intraperitoneally injected with 0.2 ml of media from intact (ICM) or cryopreserved (CCM) cultures for 9 days. On the 30th – 32nd day after the end of the administration of CM animals were slaughtered and the uterine contractile activity was determined by the organ bath method, the relative area of myometrium and density of myocytes by histological method, the average area of labeling with specific antibodies to smooth muscle actin by immunohistochemical method. The statistical significance of differences was assessed by the Mann–Whitney test.
      Results. It was found that spontaneous, OT-, and KCl-induced tension of isometric contraction of the uterus in intact LRA rats decreased by 19, 20, and 14%, respectively, compared with intact reproductive aged animals. After the introduction of ICM and CCM in LRA animals, normalization of isometric contraction parameters was observed. This effect was realized against the background of an increase in the area of the myometrium, the density of myocytes, and actin expression.
      Conclusions. Intra-abdominal administration of CM from glial cell culture increases the uterine contractile activity in LRA rats. This effect is realized by increasing the relative area of the myometrium, the density
      of myocytes, and the area of expression of smooth muscle actin. The effect of media from intact and cryopreserved cultures on the contractile activity of the uterus was similar, which makes it possible to use low-temperature culture storage technologies to obtain CM without losing its biological effect.
      PubDate: 2022-05-27
      DOI: 10.18370/2309-4117.2022.63.85-90
  • Clinical and morphological features of post-castration syndrome in women
           after surgical menopause

    • Authors: L.I. Butina, O.V. Olshevska, L.P. Shelestova, F.O. Khancha
      Pages: 92 - 96
      Abstract: Research objective: to assess the clinical and morphological features of the course of post-castration syndrome (PS) in women after surgical menopause.
      Materials and methods. The main group (with surgical menopause) consisted of 67 women aged 45 to 55 years, who underwent surgical treatment with removal of the uterus with or without appendages. 30 women with natural menopause were included in the comparison group.
      The assessment of morphological changes in the reproductive organs in both groups was carried out according to the results of the histological examination of reproductive organs removed during the operation, and according to the results of the pathological examination of endometrium after curettage of uterine mucosa.
      Results. The leading indication for surgical treatment, which led to surgical menopause, was uterine leiomyoma in 71.1% of women. Extirpation of the uterus was performed in 64.2% of patients, complete exclusion of ovarian function was observed in 68.7%.
      There was a deficiency of estrogen in women with surgical menopause, even before the operation, as evidenced by the presence of morphological signs of hypoestrogenism in the form of endometrial atrophy in 41.8% of them, which is 6.2 times (p < 0.001) more often compared with women with natural menopause.
      The morphological signs of the inflammatory process in reproductive organs in more than half of women with surgical menopause (significantly more than in women with natural menopause, p < 0.001) increase the likelihood of depletion of the ovarian hormonal function and increase the intensity of PS symptoms. This is evidenced by a significant 2.8-fold increase in women with surgical menopause in the frequency of severe PS and the median of the modified Kupperman index compared with women with natural menopause (p < 0.001). The decrease in the ovarian hormonal function in women after surgical menopause increases the frequency of ovarian cysts by 12 times compared with women with natural menopause (p < 0.001).
      Conclusions. It is necessary to establish the significance of the investigated clinical and morphological features observed in women with surgical menopause to predict the severity of PS in them.
      PubDate: 2022-05-27
      DOI: 10.18370/2309-4117.2022.63.92-96
  • Legal relations in the field of human reproductive activity

    • Authors: M.M. Blikhar, I.M. Zharovska, B.B. Shandra, O.S. Zaiats
      Pages: 97 - 104
      Abstract: The article presents a comprehensive analysis of legal relations in the field of human reproductive activity by studying international and national legal regulation and changes in legal standards caused by the coronavirus crisis. Genesis of the legal regulation of human rights to reproduction has been studied and axiological and value determinants of legal relations in the field of reproductive activity have been determined. Current international standards are positioned as legal standards that affect the ability to determine the number of children, the intervals between their births, the provision of reproductive and sexual health, as well as the relationship regarding the preservation of their own genetic material.
      It is motivated that international norms establish the autonomy of women for the right to perform abortion in particular and the right to individual determination of human reproductive function in general. In particular, it is substantiated that despite considerable scientific advances, especially in the molecular sphere, reproductive activity as a system requires multidimensional study, including its spatial and temporal definition. In addition, issues related to research in the field of stem cell biology, microfluidics, integration of unicellular transcriptomics, etc. are relevant today, which will help to determine the normal and healthy functioning of human reproductive function. In particular, it will allow studying external impacts and diseases, including endocrine disorders in the body and aging. The national legal norms concerning the right to abortion and other rights in this field are studied.
      The article is based on the materials of a survey based on author’s questionnaires conducted to determine the level of realization of their reproductive rights by Ukrainian citizens during the pandemic caused by COVID-19. It is proved that the legal policy of states on reproductive rights during pandemic threats has transformed the possibility of free exercise of reproductive law. Today there is a problem of access to reproductive procedures, in particular due to their postponement indefinitely as non-priority, due to the inaccessibility of health authorities, social distance and the ban on crossing the state border, requirement for testing.
      PubDate: 2022-05-27
      DOI: 10.18370/2309-4117.2022.63.97-104
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