Subjects -> MEDICAL SCIENCES (Total: 8196 journals)
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ENDOCRINOLOGY (149 journals)                     

Showing 1 - 134 of 134 Journals sorted alphabetically
AACE Clinical Case Reports     Hybrid Journal   (Followers: 5)
Acta Diabetologica     Hybrid Journal   (Followers: 17)
Adipositas - Ursachen, Folgeerkrankungen, Therapie     Hybrid Journal   (Followers: 1)
Advances in Chronic Kidney Disease     Hybrid Journal   (Followers: 15)
Advances in Diabetes and Metabolism     Open Access   (Followers: 22)
Advances in Endocrinology     Open Access   (Followers: 7)
AJP Endocrinology and Metabolism     Hybrid Journal   (Followers: 25)
American Journal of Kidney Diseases     Hybrid Journal   (Followers: 53)
Annales d'Endocrinologie     Hybrid Journal   (Followers: 2)
Applied Physiology, Nutrition and Metabolism     Hybrid Journal   (Followers: 37)
Best Practice & Research Clinical Endocrinology & Metabolism     Hybrid Journal   (Followers: 15)
BMC Endocrine Disorders     Open Access   (Followers: 8)
Case Reports in Endocrinology     Open Access   (Followers: 3)
Clinical Diabetes     Full-text available via subscription   (Followers: 40)
Clinical Diabetes and Endocrinology     Open Access   (Followers: 20)
Clinical Endocrinology     Hybrid Journal   (Followers: 42)
Clinical Medicine Insights : Endocrinology and Diabetes     Open Access   (Followers: 29)
Clinical Nutrition Insight     Full-text available via subscription   (Followers: 13)
Clinical Reviews in Bone and Mineral Metabolism     Hybrid Journal  
Comprehensive Psychoneuroendocrinology     Open Access  
Current Opinion in Endocrine and Metabolic Research     Hybrid Journal   (Followers: 1)
Current Opinion in Endocrinology, Diabetes and Obesity     Hybrid Journal   (Followers: 48)
Dermato-Endocrinology     Open Access   (Followers: 3)
Diabesity     Open Access   (Followers: 3)
Diabetes & Metabolic Syndrome: Clinical Research & Reviews     Hybrid Journal   (Followers: 27)
Diabetes & Metabolism     Hybrid Journal   (Followers: 72)
Diabetes, Obesity and Metabolism     Hybrid Journal   (Followers: 261)
Diabetes/Metabolism Research and Reviews     Hybrid Journal   (Followers: 63)
Diabetology & Metabolic Syndrome     Open Access   (Followers: 8)
Discover Oncology     Open Access   (Followers: 1)
Domestic Animal Endocrinology     Hybrid Journal   (Followers: 6)
Dubai Diabetes and Endocrinology Journal     Open Access  
Egyptian Journal of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Endocrine     Hybrid Journal   (Followers: 11)
Endocrine and Metabolic Science     Open Access   (Followers: 1)
Endocrine Connections     Open Access   (Followers: 4)
Endocrine Disruptors     Open Access  
Endocrine Journal     Open Access   (Followers: 13)
Endocrine Pathology     Hybrid Journal   (Followers: 7)
Endocrine Practice     Hybrid Journal   (Followers: 58)
Endocrine Regulations     Open Access  
Endocrine Research     Hybrid Journal   (Followers: 3)
Endocrine Reviews     Full-text available via subscription   (Followers: 44)
Endocrine, Metabolic & Immune Disorders - Drug Targets     Hybrid Journal   (Followers: 1)
Endocrine-Related Cancer     Full-text available via subscription   (Followers: 2)
Endocrinología, Diabetes y Nutrición (English Edition)     Hybrid Journal   (Followers: 2)
Endocrinology     Full-text available via subscription   (Followers: 50)
Endocrinology and Metabolism Clinics of North America     Full-text available via subscription   (Followers: 28)
Endocrinology, Diabetes & Metabolism     Open Access  
Endocrinology, Diabetes & Metabolism Case Reports     Open Access  
Endocrinology, Obesity and Metabolic Disorders     Full-text available via subscription   (Followers: 6)
Endokrynologia Polska     Open Access   (Followers: 2)
European Journal of Endocrinology     Full-text available via subscription   (Followers: 40)
European Thyroid Journal     Full-text available via subscription   (Followers: 3)
Experimental and Clinical Endocrinology & Diabetes     Hybrid Journal   (Followers: 24)
Experimental and Clinical Endocrinology & Diabetes Reports     Open Access   (Followers: 4)
Expert Opinion on Drug Metabolism & Toxicology     Hybrid Journal   (Followers: 15)
Expert Review of Endocrinology & Metabolism     Hybrid Journal   (Followers: 7)
Frontiers in Clinical Diabetes and Healthcare     Open Access  
Frontiers in Endocrinology     Open Access   (Followers: 5)
Frontiers in Neuroendocrine Science     Open Access  
Frontiers in Neuroendocrinology     Hybrid Journal   (Followers: 10)
General and Comparative Endocrinology     Hybrid Journal   (Followers: 5)
Growth Hormone & IGF Research     Hybrid Journal   (Followers: 14)
Gynakologische Endokrinologie     Hybrid Journal  
Gynecological Endocrinology     Hybrid Journal   (Followers: 5)
Hormone and Metabolic Research     Hybrid Journal   (Followers: 16)
Hormone Research in Paediatrics     Full-text available via subscription   (Followers: 16)
Hormones : International Journal of Endocrinology and Metabolism     Hybrid Journal  
Hormones and Behavior     Hybrid Journal   (Followers: 12)
Indian Journal of Endocrinology and Metabolism     Open Access   (Followers: 4)
International Journal of Clinical Endocrinology and Metabolism     Open Access   (Followers: 1)
International journal of endocrine oncology     Open Access  
International Journal of Endocrinology     Open Access   (Followers: 3)
International Journal of Endocrinology     Open Access   (Followers: 1)
International Journal of Endocrinology and Metabolism     Open Access   (Followers: 3)
International Journal of Obesity     Hybrid Journal   (Followers: 90)
International Journal of Osteoporosis and Metabolic Disorders     Open Access   (Followers: 1)
International Journal of Pediatric Endocrinology     Open Access   (Followers: 11)
JIMD Reports     Open Access  
Journal für Gynäkologische Endokrinologie/Österreich     Hybrid Journal  
Journal für Klinische Endokrinologie und Stoffwechsel : Austrian Journal of Clinical Endocrinology and Metabolism     Hybrid Journal  
Journal of Bone and Mineral Metabolism     Hybrid Journal   (Followers: 5)
Journal of Clinical and Translational Endocrinology     Open Access  
Journal of Clinical and Translational Endocrinology Case Reports     Open Access   (Followers: 2)
Journal of Clinical Endocrinology & Metabolism     Full-text available via subscription   (Followers: 139)
Journal of Developmental Origins of Health and Disease     Hybrid Journal   (Followers: 2)
Journal of Diabetes and Endocrinology     Open Access   (Followers: 7)
Journal of Diabetes and Endocrinology Assocation of Nepal     Open Access  
Journal of Diabetes and Metabolic Disorders     Open Access   (Followers: 8)
Journal of Diabetes Science and Technology     Hybrid Journal   (Followers: 13)
Journal of Diabetology     Open Access   (Followers: 1)
Journal of Endocrinological Investigation     Full-text available via subscription   (Followers: 7)
Journal of Endocrinology     Full-text available via subscription   (Followers: 13)
Journal of Endocrinology and Metabolism     Open Access   (Followers: 5)
Journal of Endocrinology and Reproduction     Hybrid Journal  
Journal of Endocrinology, Metabolism and Diabetes of South Africa     Open Access   (Followers: 8)
Journal of Inborn Errors of Metabolism and Screening     Open Access  
Journal of Molecular Endocrinology     Full-text available via subscription   (Followers: 5)
Journal of Neuroendocrinology     Hybrid Journal   (Followers: 8)
Journal of Pineal Research     Hybrid Journal   (Followers: 1)
Journal of Renal and Hepatic Disorders     Open Access  
Journal of Restorative Medicine     Open Access  
Journal of Social Health and Diabetes     Open Access   (Followers: 1)
Journal of the ASEAN Federation of Endocrine Societies     Open Access  
Kidney International     Hybrid Journal   (Followers: 52)
Kidney Research Journal     Open Access   (Followers: 6)
L'Endocrinologo     Hybrid Journal  
Metabolic Brain Disease     Hybrid Journal   (Followers: 1)
Metabolic Syndrome and Related Disorders     Hybrid Journal   (Followers: 5)
Metabolism     Hybrid Journal   (Followers: 11)
Molecular and Cellular Endocrinology     Hybrid Journal   (Followers: 8)
Molecular Metabolism     Open Access   (Followers: 9)
Nature Reviews Endocrinology     Full-text available via subscription   (Followers: 60)
Neuroendocrinology     Full-text available via subscription   (Followers: 8)
Nigerian Endocrine Practice     Full-text available via subscription  
Nutrition in Clinical Practice     Hybrid Journal   (Followers: 43)
Open Journal of Endocrine and Metabolic Diseases     Open Access   (Followers: 1)
Psychoneuroendocrinology     Hybrid Journal   (Followers: 15)
Reproductive Biology and Endocrinology     Open Access   (Followers: 3)
Reproductive Endocrinology     Open Access   (Followers: 1)
Reviews in Endocrine and Metabolic Disorders     Hybrid Journal   (Followers: 2)
Revista Argentina de Endocrinología y Metabolismo     Open Access  
Revista Cubana de Endocrinología     Open Access  
Revista Venezolana de Endocrinología y Metabolismo     Open Access  
Sri Lanka Journal of Diabetes Endocrinology and Metabolism     Open Access  
The Endocrinologist     Full-text available via subscription   (Followers: 6)
The Lancet Diabetes and Endocrinology     Full-text available via subscription   (Followers: 167)
Therapeutic Advances in Endocrinology and Metabolism     Open Access   (Followers: 5)
Thyroid     Hybrid Journal   (Followers: 11)
Thyroid Research     Open Access   (Followers: 3)
Thyroid Research and Practice     Open Access   (Followers: 3)
Trends in Endocrinology & Metabolism     Full-text available via subscription   (Followers: 19)
Vitamins & Hormones     Full-text available via subscription   (Followers: 1)


Similar Journals
Journal Cover
Endocrine Journal
Journal Prestige (SJR): 0.802
Citation Impact (citeScore): 2
Number of Followers: 13  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0918-8959 - ISSN (Online) 1348-4540
Published by Japan Endocrine Society, The  [1 journal]
  • A case of adrenocortical carcinoma diagnosed 9 years after the discovery
           of adrenal incidentaloma

    • Authors: Daisuke Aono, Mitsuhiro Kometani, Takahiro Asano, Seigo Konishi, Shigehiro Karashima, Hiroko Ikeda, Takahiro Nohara, Takashi Yoneda
      Abstract: Adrenocortical carcinoma (ACC) is an uncommon cause of adrenal incidentaloma (AI). ACCs generally occur in large sizes,>4 cm in diameter, at initial presentation and grow rapidly. Therefore, there have been few reports of cases with long-term follow-up with imaging before ACC was diagnosed. Herein, we present a case of an adrenal mass that had remained small and unchanged for 5 years but later grew rapidly and was finally diagnosed as ACC. A 77-year-old hypertensive woman was referred to our...
      Citation: Endocrine journal
      PubDate: 2022-08-07
      DOI: 10.1507/endocrj.EJ22-0171
  • Increased alpha cell to beta cell ratio in patients with pancreatic cancer

    • Authors: Tami Tsuchiya, Yoshifumi Saisho, Jun Inaishi, Hironobu Sasaki, Midori Sato, Masaru Nishikawa, Yohei Masugi, Taketo Yamada, Hiroshi Itoh
      Abstract: The development of pancreatic cancer (PC) is associated with worsening of glucose tolerance. However, there is limited information about the effects of PC on islet morphology. The aim of this study was to elucidate changes in alpha and beta cell mass in patients with PC. We enrolled 30 autopsy cases with death due to PC (9 with diabetes; DM) and 31 age- and BMI-matched autopsy cases without PC (controls, 12 with DM). Tumor-free pancreatic sections were stained for insulin and glucagon, and...
      Citation: Endocrine journal
      PubDate: 2022-08-07
      DOI: 10.1507/endocrj.EJ22-0170
  • Re-expression of circ_0043610 contributes to trophoblast dysfunction
           through the miR-558/RYBP pathway in preeclampsia

    • Authors: Jing Shang, Li Lin, Xiumin Huang, Lihua Zhou, Qi Huang
      Abstract: An increasing number of data have shown the pathogenesis of preeclampsia (PE) involves circular RNA (circRNA). The study aims to investigate the function and the potential mechanism of circ_0043610 in PE. The study was performed on two human placental trophoblastic cell lines (JEG-3 and HTR-8/SVneo). The expression of circ_0043610, microRNA-558 (miR-558), and RING1 and YY1 binding protein (RYBP) was detected by quantitative real-time polymerase chain reaction. The protein levels of N-cadherin,...
      Citation: Endocrine journal
      PubDate: 2022-07-31
      DOI: 10.1507/endocrj.EJ22-0153
  • Exenatide challenge in oral glucose tolerance test is insufficient for
           predictions of glucose metabolism and insulin secretion after sleeve
           gastrectomy (SG) in obese patients with type 2 diabetes: a pilot study to
           establish a preoperative model to estimate β-cell function following
           augmented glucagon-like peptide-1 secretion after SG

    • Authors: Yuta Nakamura, Ichiro Horie, Kengo Kanetaka, Susumu Eguchi, Seiko Nakamichi, Ryoko Hongo, Miwa Takashima, Atsushi Kawakami, Norio Abiru
      Abstract: The postoperative increase in glucagon-like peptide-1 (GLP-1) is the main factor to improve glucose metabolism following sleeve gastrectomy (SG) in obese patients with type 2 diabetes. We investigated whether the β-cell responsiveness to an injection of exogenous GLP-1 in the preoperative period could determine the postoperative glucose tolerance in 18 patients underwent SG. In the preoperative period, a regular oral glucose tolerance test (OGTT) and an exenatide-challenge during OGTT (Ex-OGTT)...
      Citation: Endocrine journal
      PubDate: 2022-07-27
      DOI: 10.1507/endocrj.EJ22-0224
  • Role of thyroid hormone in an experimental model of atherosclerosis: the
           potential mediating role of immune response and autophagy

    • Authors: Kenji Ohba, Takayuki Iwaki
      Abstract: Accumulating evidence has revealed that several conditions related to abnormal thyroid hormone status, such as dyslipidemia, hypertension, or hypercoagulable state, can exacerbate atherosclerotic vascular disease. Thyroid hormone effects on vascular smooth muscle cells and endothelial cells have also been studied extensively. However, only limited information is available on thyroid hormone-mediated immune response in current review articles on the pathophysiology of atherosclerosis. This report...
      Citation: Endocrine journal
      PubDate: 2022-07-24
      DOI: 10.1507/endocrj.EJ22-0177
  • Therapeutic role of mesenchymal stem cells (MSCs) in diabetic kidney
           disease (DKD)

    • Authors: Ning Xu, Jie Liu, Xiangling Li
      Abstract: Findings of preclinical studies and recent phase I/II clinical trials have shown that mesenchymal stem cells (MSCs) play a significant role in the development of diabetic kidney disease (DKD). Thus, MSCs have attracted increasing attention as a novel regenerative therapy for kidney diseases. This review summarizes recent literature on the roles and potential mechanisms, including hyperglycemia regulation, anti-inflammation, anti-fibrosis, pro-angiogenesis, and renal function protection, of...
      Citation: Endocrine journal
      PubDate: 2022-07-20
      DOI: 10.1507/endocrj.EJ22-0123
  • Increases in serum carbonylated protein levels of dogs with

    • Authors: HakChung Kim, Tomohiro Yonezawa, Shingo Maeda, Satoshi Tamahara, Naoaki Matsuki
      Abstract: Protein carbonylation is an irreversible and degenerative modification that can be used to evaluate oxidative stress caused by glucocorticoids. In this study, we focused on protein carbonylation in dogs with hypercortisolism (HC). Sera samples were collected from 14 dogs diagnosed with HC and treated with trilostane, 12 dogs with inflammatory diseases (disease control group), and eight clinically healthy dogs. When the carbonylated protein levels were detected by the immunoblot analysis, one...
      Citation: Endocrine journal
      PubDate: 2022-07-20
      DOI: 10.1507/endocrj.EJ22-0075
  • Coexistence of growth hormone, adrenocorticotropic hormone, and
           testosterone deficiency associated with coronavirus disease 2019: a case
           followed up for 15 months

    • Authors: Kai Yoshimura, Masaaki Yamamoto, Tomoya Inoue, Hidenori Fukuoka, Keiji Iida, Wataru Ogawa
      Abstract: Coronavirus disease 2019 (COVID-19) is associated with endocrine disorders, but their long-term clinical course remains unclear. We here report the 15-month clinical course for an individual with multiple endocrine disorders of the pituitary gland and testis likely triggered by COVID-19. A 65-year-old man with no history of endocrinopathy was admitted for acute COVID-19 pneumonia. Although his respiratory condition improved after administration of antiviral drugs, his blood pressure dropped...
      Citation: Endocrine journal
      PubDate: 2022-07-13
      DOI: 10.1507/endocrj.EJ22-0108
  • A simple questionnaire for the detection of testosterone deficiency in men
           with late-onset hypogonadism

    • Authors: Yuko Akehi, Makito Tanabe, Hiromi Yano, Yuichi Takashi, Daiji Kawanami, Takashi Nomiyama, Toshihiko Yanase
      Abstract: The Aging Males' Symptoms (AMS) score, developed to screen for late-onset hypogonadism (LOH), contains 17 questions regarding mental, physical, and sexual parameters. In the Japanese guidelines, a free testosterone (FT)
      Citation: Endocrine journal
      PubDate: 2022-07-13
      DOI: 10.1507/endocrj.EJ22-0073
  • Advances in understanding of phosphate homeostasis and related disorders

    • Authors: Toshimi Michigami
      Abstract: Inorganic phosphate (Pi) in the mammalian body is balanced by its influx and efflux through the intestines, kidneys, bones, and soft tissues, at which several sodium/Pi co-transporters mediate its active transport. Pi homeostasis is achieved through the complex counter-regulatory feedback balance between fibroblast growth factor 23 (FGF23), 1,25-dihydroxyvitamin D (1,25(OH)(2)D), and parathyroid hormone. FGF23, which is mainly produced by osteocytes in bone, plays a central role in Pi...
      Citation: Endocrine journal
      PubDate: 2022-07-13
      DOI: 10.1507/endocrj.EJ22-0239
  • Gestational trimester-specific reference ranges for serum thyrotropin and
           free thyroxine in Japanese

    • Authors: Yozen Fuse, Yoshiya Ito, Yoshimasa Shishiba, Minoru Irie
      Abstract: Thyroid diseases in pregnant and lactating women may result in adverse outcomes for both mothers and infants. A reference range for thyroid function is required in different areas; however, few studies on the gestational change or reference ranges of thyrotropin (TSH) and free thyroxine (FT4) concentrations for Japanese pregnant women have been reported. To establish the gestational trimester-specific reference ranges of serum TSH and FT4 concentrations, our previously published data on 481...
      Citation: Endocrine journal
      PubDate: 2022-07-10
      DOI: 10.1507/endocrj.EJ22-0237
  • Screening methods for gestational diabetes mellitus in Japan in 2018: a
           retrospective cohort study using a national surveillance questionnaire

    • Authors: Mamoru Morikawa, Takashi Sugiyama, Yuji Hiramatsu, Norimasa Sagawa
      Abstract: This study aimed to investigate the relationship between gestational diabetes mellitus (GDM) screening methods and GDM incidences. In 2018, a national questionnaire was administered at 231 institutions (56.6%) of all 408 perinatal medical centers in Japan. Of 100,485 women, 2,982 (3.0%) were diagnosed with GDM during their first pregnancy period (FPP) and 7,289 (7.3%) were diagnosed with GDM during their middle pregnancy period (MPP). The proportion of women diagnosed with GDM during FPP and MPP...
      Citation: Endocrine journal
      PubDate: 2022-07-05
      DOI: 10.1507/endocrj.EJ22-0072
  • Clinicopathological features and outcomes of intrathyroidal thymic
           carcinoma: a single institution study

    • Authors: Yasuhiro Ito, Akira Miyauchi, Mitsuyoshi Hirokawa, Minoru Kihara, Naoyoshi Onoda, Akihiro Miya
      Abstract: Intrathyroidal thymic carcinoma (ITTC) is a rare malignancy of the thyroid. It is thought to originate from ectopic thymic tissue or embryonic thymic rest, in, or adjacent to, the thyroid. We analyzed the backgrounds, clinicopathological features, and prognosis of 20 patients with ITTC, treated at our hospital. Thirteen of the 15 patients (86%) who underwent ultrasonography were diagnosed as malignant, based on imaging findings. 16 of the 17 patients (93%) who underwent cytology, were diagnosed...
      Citation: Endocrine journal
      PubDate: 2022-06-29
      DOI: 10.1507/endocrj.EJ22-0141
  • Trends in the high blood glucose and non-alcoholic fatty liver disease
           among Korean adolescents

    • Authors: Youn Huh, Ga Eun Nam, Jisun Lim, Hye Soon Park
      Abstract: High blood glucose level and non-alcoholic fatty liver disease (NAFLD) in adolescents are long-term risk factors for cardiovascular diseases and poor prognosis. We investigated recent trends of high blood glucose levels and NAFLD among Korean adolescents aged 12-18 years. We conducted a cross-sectional analysis using data of 5,685 adolescents aged 12-18 years from the Korea National Health and Nutrition Examination Surveys (KNHANES), from 2007-2009 to 2016-2018. Linear trends in the prevalence...
      Citation: Endocrine journal
      PubDate: 2022-06-29
      DOI: 10.1507/endocrj.EJ21-0780
  • Gauze blotting technique: a novel method to identify parathyroid glands
           during thyroid surgery without tissue damage

    • Authors: Masatoshi Yamamoto, Naoyoshi Onoda, Akira Miyauchi, Makoto Fujishima, Toshitetsu Hayashi, Mitsuyoshi Hirokawa
      Abstract: Hypoparathyroidism is a major complication of thyroid surgery. To avoid this complication, visual identification of the parathyroid glands is essential. However, its effectiveness depends heavily on the surgeon's expertise. Here, we describe a novel method, the gauze blotting technique, to immunochemically identify the parathyroid glands during thyroid surgery. Twenty-three patients who underwent thyroid lobectomy were enrolled in this study; 16 and 7 had benign and malignant thyroid diseases,...
      Citation: Endocrine journal
      PubDate: 2022-06-26
      DOI: 10.1507/endocrj.EJ22-0043
  • Efficacy of a new enzyme-linked immunosorbent assay system for three islet

    • Authors: Tomoyasu Fukui, Nobuaki Takehana, Yusaku Mori, Munenori Hiromura, Michishige Terasaki, Hideki Kushima, Michiya Takada, Masako Tomoyasu, Nobuko Sato, Toshiyuki Hayashi, Makoto Ohara, Tsuyoshi Kikuchi, Yoshihisa Ito, Tetsuro Kobayashi, Sho-Ichi Yamagishi
      Abstract: To evaluate the clinical efficacy of a new enzyme-linked immunosorbent assay (ELISA) system for simultaneously detecting three islet cell autoantibodies against glutamic acid decarboxylase (GADA), insulinoma-associated antigen-2 (IA-2A), and zinc transporter 8 (ZnT8A) (3 Screen ICA ELISA) in Japanese patients with acute-onset type 1 diabetes (T1D). In addition, clinical factors affecting the 3 Screen ICA ELISA index were investigated. We compared the positivity values of 3 Screen ICA ELISA with...
      Citation: Endocrine journal
      PubDate: 2022-06-26
      DOI: 10.1507/endocrj.EJ22-0146
  • Update on subclinical thyroid dysfunction

    • Authors: Koshi Hashimoto
      Abstract: Subclinical thyroid dysfunction is defined by serum thyroid-stimulating hormone (TSH) levels either greater or less than the reference range with normal thyroxine (T4) concentrations, and consists of subclinical hypothyroidism (SCH) and subclinical hyperthyroidism (SCHyper). For the proper diagnosis of SCH, it is most important to be able to correctly evaluate the serum TSH levels, which have numerous unique characteristics. We also need to be versed in TSH harmonization, which was recently...
      Citation: Endocrine journal
      PubDate: 2022-06-22
      DOI: 10.1507/endocrj.EJ22-0182
  • Subclinical acromegaly: to treat or not to treat'

    • Authors: Ilan Shimon, Zaina Adnan, Dania Hirsch, Hadar Duskin-Bitan, Amit Akirov
      Abstract: Patients with acromegaly usually present with the classical signs of acromegaly, whereas patients without the specific signs or symptoms are rarely diagnosed. This unique entity can be named "subclinical acromegaly". This was a retrospective study. Our study group consisted of 6 patients (4 females) with incidentally diagnosed acromegaly, most following head MRI for unrelated reasons and without the specific signs of acromegaly. Mean age at diagnosis was 48.8 ± 19.2 years. Baseline IGF-1 ranged...
      Citation: Endocrine journal
      PubDate: 2022-06-22
      DOI: 10.1507/endocrj.EJ22-0066
  • Significance of interstitial fibrosis and p16 in papillary thyroid

    • Authors: Hong-Qun Wang, Ying Li, Xin Song, Ya-Qi Ma, Jin-Long Li, Ying-Xue Li, Gao-Fei Wang, Peng Liu, Ping-Li Liu, Cao Shen, Huai-Yin Shi
      Abstract: We enrolled 264 patients with papillary thyroid carcinoma (PTC). We performed immunohistochemical detection of p16 and determined the degree of interstitial fibrosis (IF). The expression of p16 was associated with pathological tumor-node-metastasis (pTNM) stage and age (p < 0.05). The overall survival was longer in p16-negative patients (195.73 vs. 181.78 months, p = 0.007). p16 was significantly related to the degree of IF (r = 0.130, p = 0.035). PTC patients with no or mild fibrosis tended to...
      Citation: Endocrine journal
      PubDate: 2022-06-19
      DOI: 10.1507/endocrj.EJ22-0010
  • A novel anti-obesity mechanism for liraglutide by improving adipose tissue
           leptin resistance in high-fat diet-fed obese mice

    • Authors: Xiaorui Lyu, Kemin Yan, Xin Wang, Hanyuan Xu, Xiaonan Guo, Huijuan Zhu, Hui Pan, Linjie Wang, Hongbo Yang, Fengying Gong
      Abstract: Liraglutide has been approved for the treatment of obesity in the past few years. Both oxidative stress and leptin resistance are the critical drivers of obesity. The present study investigated the mechanism of liraglutide protection against obesity by ameliorating leptin resistance and oxidative stress. Male C57BL/6J mice were fed a high-fat diet (HFD) and subcutaneously injected with 200 μg/kg/d liraglutide for 20 weeks. Body weight, fat mass, serum levels of leptin, insulin, and superoxide...
      Citation: Endocrine journal
      PubDate: 2022-06-15
      DOI: 10.1507/endocrj.EJ21-0802
  • Comparing the course and delivery outcomes of Japanese twin pregnancies
           with and without gestational diabetes mellitus: a single-center
           retrospective analysis

    • Authors: Mai Sugiyama, Tadashi Yamakawa, Marina Harada, Akeo Ohira, Masahiro Ichikawa, Tomoaki Akiyama, Kazuki Orime, Sayuri Nakanishi, Shigeru Aoki, Yasuo Terauchi
      Abstract: Singleton pregnant women with gestational diabetes mellitus (GDM) are at an increased risk of adverse maternal and neonatal outcomes. Multiple pregnancies are associated with increased risks of perinatal complications; however, the impact of GDM on maternal and neonatal outcomes in multiple pregnancies is unknown, and there are currently few reports on GDM status in twin pregnancies. This study aimed to compare the background and perinatal outcomes between Japanese twin pregnancies with and...
      Citation: Endocrine journal
      PubDate: 2022-06-15
      DOI: 10.1507/endocrj.EJ21-0537
  • Lipoadenoma of the parathyroid: characteristics of a rare cause of

    • Authors: Naoyoshi Onoda, Mitsuyoshi Hirokawa, Akihiro Miya, Takahiro Sasaki, Makoto Fujishima, Hiroo Masuoka, Takuya Higashiyama, Minoru Kihara, Akira Miyauchi
      Abstract: Parathyroid Lipoadenoma (PLA) contains abundant mature adipose tissue and is a rare cause of hyperparathyroidism. This study aimed to investigate the clinical features of PLA in nine patients with primary hyperparathyroidism, including two men and seven women, with ages ranging from 45-84 years (median 60 years). PLA accounted for 0.5% of all parathyroid tumors during the study period. One patient presented with anorexia due to hypercalcemia; however, the other eight patients were asymptomatic....
      Citation: Endocrine journal
      PubDate: 2022-06-12
      DOI: 10.1507/endocrj.EJ22-0118
  • Multiple endocrine neoplasia type 2 and autoimmune polyendocrine syndromes
           (type 1 diabetes mellitus and Graves' disease) in a 16-year-old male with
           Kabuki syndrome

    • Authors: Esther Park, Min-Sun Kim, Eu Seon Noh, Ji-Eun Lee, Su Jin Kim, Young Se Kwon, Sung Yoon Cho
      Abstract: Multiple endocrine neoplasia type 2A (MEN2A) is caused by germline pathogenic variants in the RET proto-oncogene and is characterized by medullary thyroid cancer (MTC), pheochromocytoma, and hyperparathyroidism. Autoimmune polyendocrine syndromes (APS) are defined as multiple endocrine gland insufficiency associated with loss of immune tolerance. APS type 2 (APS-2) consists of at least two of the following diseases: type 1 diabetes mellitus (T1DM), autoimmune thyroid disease, and Addison's...
      Citation: Endocrine journal
      PubDate: 2022-06-08
      DOI: 10.1507/endocrj.EJ22-0084
  • Anti-Müllerian hormone levels in the diagnosis of adolescent polycystic
           ovarian syndrome: a systematic review and meta-analysis

    • Authors: Yumiko Tsukui, Yoshikazu Kitahara, Yuko Hasegawa, Mio Kobayashi, Satoko Osuka, Akira Iwase
      Abstract: Polycystic ovary syndrome (PCOS) is an endocrine disorder that causes menstrual cycle irregularities and infertility. PCOS is diagnosed based on hyperandrogenism, polycystic ovarian morphology (PCOM), and an-/oligo-ovulation. Upregulation of anti-Müllerian hormone (AMH) in the serum of women with PCOS may be another suitable alternative diagnostic criterion for PCOM. However, previous meta-analyses have reported conflicting results due to the age-dependent decline in serum AMH levels. Therefore,...
      Citation: Endocrine journal
      PubDate: 2022-06-08
      DOI: 10.1507/endocrj.EJ22-0081
  • New perspectives on obesity-induced adipose tissue fibrosis and related
           clinical manifestations

    • Authors: Yutaka Hasegawa
      Abstract: Adipose tissue is a complex heterogeneous tissue composed of adipocytes along with several non-adipocyte populations, including blood, stromal, endothelial, and progenitor cells, as well as extracellular matrix (ECM) components. As obesity progresses, the adipose tissue expands dynamically through adipocyte hypertrophy and/or hyperplasia. This expansion requires continuous ECM remodeling to properly accommodate the size increase as well as functional changes. Upon reaching a hypertrophic...
      Citation: Endocrine journal
      PubDate: 2022-06-08
      DOI: 10.1507/endocrj.EJ22-0035
  • Thyroid stimulating hormone suppresses the expression and activity of
           cytosolic sulfotransferase 1a1 in thyrocytes

    • Authors: Yasuhiro Nakamura, Aya Yoshihara, Mitsuo Kiriya, Akira Kawashima, Kazunari Tanigawa, Yuqian Luo, Yoko Fujiwara, Keiji Maruyama, Shigekazu Watanabe, Fumiko Kihara-Negishi, Ken Karasawa, Koichi Suzuki
      Abstract: Sulfonation is an important step in the metabolism of dopamine, estrogens, dehydroepiandrosterone, as well as thyroid hormones. However, the regulation of cytosolic sulfotransferases in the thyroid is not well understood. In a DNA microarray analysis of rat thyroid FRTL-5 cells, we found that the mRNA expression of 10 of 48 sulfotransferases was significantly altered by thyroid stimulating hormone (TSH), with that of sulfotransferase family 1A member 1 (SULT1A1) being the most significantly...
      Citation: Endocrine journal
      PubDate: 2022-06-08
      DOI: 10.1507/endocrj.EJ22-0055
  • Surgical indications for upper mediastinal dissection by sternotomy in
           patients with papillary thyroid carcinoma

    • Authors: Sueyoshi Moritani, Masao Takenobu, Masakazu Yasunaga, Katsuyuki Kawamoto, Taihei Fujii, Yukiya Ishida, Hiroya Kitano
      Abstract: Papillary thyroid carcinoma (PTC) is a relatively indolent disease, despite the high incidence of lymph node metastases. Although less frequent, some upper mediastinal metastases of PTC cannot be removed without sternal resection. In this study, we investigated the prognostic impact of upper mediastinal dissection (UMD) by sternotomy on patients with mediastinal metastases of PTC. Charts of patients with PTC who underwent surgical treatment at our institution between 2006 and 2018 were...
      Citation: Endocrine journal
      PubDate: 2022-06-01
      DOI: 10.1507/endocrj.EJ22-0033
  • A clinical analysis on functioning pancreatic neuroendocrine tumors
           (focusing on VIPomas): a single-center experience

    • Authors: Masatoshi Murakami, Nao Fujimori, Kazuhide Matsumoto, Akihisa Ohno, Katsuhito Teramatsu, Yu Takamatsu, Ayumu Takeno, Keijiro Ueda, Takamasa Oono, Tetsuhide Ito, Yoshihiro Ogawa
      Abstract: VIPomas are generally rare functioning pancreatic neuroendocrine tumors (PanNETs) that cause watery diarrhea, hypokalemia, and achlorhydria. Due to their extreme rarity, the clinicopathological features and outcomes of VIPomas have not been well reported. This study aimed to determine the diagnostic and therapeutic characteristics and prognosis of VIPomas and to compare them with other PanNETs at a Japanese reference hospital. Medical records of 293 patients with PanNETs were collected. Patient...
      Citation: Endocrine journal
      PubDate: 2022-06-01
      DOI: 10.1507/endocrj.EJ22-0111
  • Thyroglobulin regulates the expression and localization of the novel
           iodide transporter solute carrier family 26 member 7 (SLC26A7) in

    • Authors: Mitsuo Kiriya, Akira Kawashima, Yoko Fujiwara, Yuta Tanimura, Aya Yoshihara, Yasuhiro Nakamura, Kazunari Tanigawa, Tetsuo Kondo, Koichi Suzuki
      Abstract: Solute carrier family 26 member 7 (SLC26A7), identified as a causative gene for congenital hypothyroidism, was found to be a novel iodide transporter expressed on the apical side of the follicular epithelium of the thyroid. We recently showed that TSH suppressed the expression of SLC26A7 and induces its localization to the plasma membrane, where it functions. We also showed that the ability of TSH to induce thyroid hormone synthesis is completely reversed by an autocrine negative-feedback action...
      Citation: Endocrine journal
      PubDate: 2022-06-01
      DOI: 10.1507/endocrj.EJ22-0082
  • Activin A specifically suppresses the expression of annexin A5 mRNA and
           augments gonadotropin-releasing hormone stimulation of A1 expression in
           LβT2 gonadotrope cells

    • Authors: Takuya Murata, Shuichi Chiba, Mitsumori Kawaminami
      Abstract: Recently, we reported that gonadotropin-releasing hormone (GnRH) stimulates annexin A1 (Anxa1) and A5 (Anxa5) mRNA expression through the GnRH-receptor-mitogen-activated protein kinase cascade in LβT2 cells. As LβT2 cells respond to activin, we examined the effect of activin A on Anxa1 and a5 expression in LβT2 cells. Activin A (0.4 and 4 ng/mL) treatment decreased Anxa5 mRNA levels in a dose-dependent manner, but did not affect Anxa1 mRNA levels at concentrations up to 40 ng/mL. After activin A...
      Citation: Endocrine journal
      PubDate: 2022-05-18
      DOI: 10.1507/endocrj.EJ22-0095
  • Overexpression of lncRNA HCP5 in human umbilical cord mesenchymal stem
           cell-derived exosomes promoted the proliferation and inhibited the
           apoptosis of ovarian granulosa cells via the musashi RNA-binding protein
           2/oestrogen receptor alpha 1 axis

    • Authors: Yu-Ting Sun, Jun-Hong Cai, Shan Bao
      Abstract: HCP5 has been reported to be downregulated in ovarian granulosa cells (OGCs) and to facilitate cell proliferation. Human umbilical cord mesenchymal stem cell exosome (hucMSCs-exo) treatment can prevent OGCs apoptosis in vitro. However, the functional mechanism of HCP5 and hucMSCs-exo requires further exploration. Fluorescence-activated cell sorting (FACS) was performed to measure the expression of markers related to hucMSCs. The osteogenic and adipogenic potential of hucMSCs was measured by...
      Citation: Endocrine journal
      PubDate: 2022-05-11
      DOI: 10.1507/endocrj.EJ21-0653
  • Circ_FOXP1 promotes the growth and survival of high glucose-treated human
           trophoblast cells through the regulation of miR-508-3p/SMAD family member
           2 pathway

    • Authors: Mingqun Li, Yuqin Huang, Hongli Xi, Wei Zhang, Ziwu Xiang, Lingyun Wang, Xuanyu Li, Hongyan Guo
      Abstract: Gestational diabetes mellitus (GDM) is a health risk for pregnant women and infants. Emerging evidence suggests that the deregulation of circular RNAs (circRNAs) is associated with the progression of this disorder. The objective of this study was to investigate the role of circ_FOXP1 in GDM. Cell models of GDM were established by treating human trophoblast cells with high glucose (HG). The expression of circ_FOXP1, miR-508-3p and SMAD family member 2 (SMAD2) mRNA was detected by quantitative...
      Citation: Endocrine journal
      PubDate: 2022-05-11
      DOI: 10.1507/endocrj.EJ21-0528
  • Prognostic factors for follicular thyroid carcinoma: the importance of
           vascular invasion

    • Authors: Yasuhiro Ito, Mitsuyoshi Hirokawa, Hiroo Masuoka, Takuya Higashiyama, Minoru Kihara, Naoyoshi Onoda, Akihiro Miya, Akira Miyauchi
      Abstract: The World Health Organization (WHO) classifies follicular thyroid carcinoma (FTC) into three categories: minimally invasive (mFTC), encapsulated angioinvasive (eaFTC), and widely invasive (wFTC). This study investigated whether this classification is appropriate. We enrolled 523 patients who underwent initial surgery at Kuma Hospital between 1998 and 2015 and were diagnosed with FTC. Capsular invasion (CI) was classified as none, minimal (microscopic), or wide (macroscopic) invasion. Vascular...
      Citation: Endocrine journal
      PubDate: 2022-05-01
      DOI: 10.1507/endocrj.EJ22-0077
  • Hormonal trends in patients suffering from long COVID symptoms

    • Authors: Naruhiko Sunada, Hiroyuki Honda, Yasuhiro Nakano, Koichiro Yamamoto, Kazuki Tokumasu, Yasue Sakurada, Yui Matsuda, Toru Hasegawa, Yuki Otsuka, Mikako Obika, Yoshihisa Hanayama, Hideharu Hagiya, Keigo Ueda, Hitomi Kataoka, Fumio Otsuka
      Abstract: Symptoms of long COVID are complex and long-lasting, and endocrine dysfunction might be involved in the underlying mechanisms. In this study, to clarify the hormonal characteristics of long COVID patients, laboratory data for patients who visited the outpatient clinic for long COVID were evaluated. A retrospective analysis was performed for patients who visited Okayama University Hospital during the period from Feb 2021 to Dec 2021 with focus on the interrelationships between major symptoms and...
      Citation: Endocrine journal
      PubDate: 2022-05-01
      DOI: 10.1507/endocrj.EJ22-0093
  • The physiological and pathophysiological roles of carbohydrate response
           element binding protein in the kidney

    • Authors: Atsushi Yokoyama, Susumu Suzuki, Koji Okamoto, Akira Sugawara
      Abstract: Glucose is not only the energy fuel for most cells, but also the signaling molecule which affects gene expression via carbohydrate response element binding protein (ChREBP), a Mondo family transcription factor. In response to high glucose conditions, ChREBP regulates glycolytic and lipogenic genes by binding to carbohydrate response elements (ChoRE) in the regulatory region of its target genes, thus elucidating the role of ChREBP for converting excessively ingested carbohydrates to fatty acids...
      Citation: Endocrine journal
      PubDate: 2022-04-27
      DOI: 10.1507/endocrj.EJ22-0083
  • Retroperitoneal paraganglioma with loss of heterozygosity of the von
           Hippel-Lindau gene: a case report and review of the literature

    • Authors: Mari Anno, Shoichiro Izawa, Yohei Fujioka, Kazuhiko Matsuzawa, Kohei Saito, Katsuya Hikita, Karen Makishima, Kanae Nosaka, Atsushi Takenaka, Takeshi Usui, Kazuhiro Yamamoto
      Abstract: Von Hippel-Lindau (VHL) disease is an autosomal dominant disease related to germline mutations in VHL. In VHL disease, pheochromocytoma develops in 10%-20% of patients because of germline mutations and loss of heterozygosity of VHL. However, the rate of paraganglioma associated with VHL is low compared with that of pheochromocytoma, and the reason is unknown. In this study, we performed germline and somatic mutation analyses of retroperitoneal paraganglioma that developed in a patient with...
      Citation: Endocrine journal
      PubDate: 2022-04-25
      DOI: 10.1507/endocrj.EJ21-0611
  • Prognostic significance of patient age in papillary thyroid carcinoma with
           no high-risk features

    • Authors: Yasuhiro Ito, Akira Miyauchi, Makoto Fujishima, Hiroo Masuoka, Takuya Higashiyama, Minoru Kihara, Naoyoshi Onoda, Akihiro Miya
      Abstract: Older age is recognized as a predictor of poor prognosis in papillary thyroid carcinoma (PTC) patients. However, young age is associated with disease progression of PTC measuring 1 cm or smaller in patients on active surveillance. In this study, we investigated the relationship between patient age and prognosis of PTC belonging to very low-, low-, and intermediate-risk groups based on the guidelines published by the Japan Association of Endocrine Surgery in 2018. We enrolled 4,870 PTC patients...
      Citation: Endocrine journal
      PubDate: 2022-04-18
      DOI: 10.1507/endocrj.EJ22-0056
  • Comparative efficiency and safety of insulin degludec/aspart with insulin
           glargine in type 2 diabetes: a meta-analysis of randomized controlled

    • Authors: Tao Long, Jin-Ting Lin, Min-Hua Lin, Qian-Long Wu, Jian-Mei Lai, Sheng-Zhen Li, Zi-Chao Zhou, Ji-Yuan Zeng, Jia-Shuan Huang, Chun-Ping Zeng, Yao-Ming Lai
      Abstract: Recent studies have found compared with insulin glargine (IGlar), insulin degludec/aspart (IDeg/Asp) may provide adequate glycemic control and prevent hypoglycemia events in type 2 diabetes mellitus (T2DM). Consequently, we performed a meta-analysis to appraise and compare the efficiency and safety of IDeg/Asp and IGlar in the treatment of T2DM. We sought the databases including PubMed, Embase, Scopus, Cochrane library to confirm related articles which inspected the effect of IDeg/Asp versus...
      Citation: Endocrine journal
      PubDate: 2022-04-18
      DOI: 10.1507/endocrj.EJ21-0692
  • Glucokinase as a therapeutic target based on findings from the analysis of
           mouse models

    • Authors: Akinobu Nakamura
      Abstract: I investigated mouse models to elucidate the pathophysiology and to establish a new treatment strategy for type 2 diabetes, with a particular focus on glucokinase. The decrease in pancreatic beta-cell function and mass are important factors in the pathophysiology of type 2 diabetes. My group have shown that glucokinase plays an important role in high-fat diet-induced and high-starch diet-induced beta-cell expansion. The findings indicated that the mechanism of short-term high-fat diet-induced...
      Citation: Endocrine journal
      PubDate: 2022-04-14
      DOI: 10.1507/endocrj.EJ21-0742
  • Japan Endocrine Society clinical practice guideline for the diagnosis and
           management of primary aldosteronism 2021

    • Authors: Mitsuhide Naruse, Takuyuki Katabami, Hirotaka Shibata, Masakatsu Sone, Katsutoshi Takahashi, Akiyo Tanabe, Shoichiro Izawa, Takamasa Ichijo, Michio Otsuki, Masao Omura, Yoshihiro Ogawa, Yutaka Oki, Isao Kurihara, Hiroki Kobayashi, Ryuichi Sakamoto, Fumitoshi Satoh, Yoshiyu Takeda, Tomoaki Tanaka, Kouichi Tamura, Mika Tsuiki, Shigeatsu Hashimoto, Tomonobu Hasegawa, Takanobu Yoshimoto, Takashi Yoneda, Koichi Yamamoto, Hiromi Rakugi, Norio Wada, Aya Saiki, Youichi Ohno, Tatsuya Haze
      Abstract: Primary aldosteronism (PA) is associated with higher cardiovascular morbidity and mortality rates than essential hypertension. The Japan Endocrine Society (JES) has developed an updated guideline for PA, based on the evidence, especially from Japan. We should preferentially screen hypertensive patients with a high prevalence of PA with aldosterone to renin ratio ≥200 and plasma aldosterone concentrations (PAC) ≥60 pg/mL as a cut-off of positive results. While we should confirm excess aldosterone...
      Citation: Endocrine journal
      PubDate: 2022-04-14
      DOI: 10.1507/endocrj.EJ21-0508
  • The sellar region as presenting theater for hematologic malignancies-A
           17-year single-center experience

    • Authors: Sandra Pekic, Marko Stojanovic, Emilija Manojlovic Gacic, Darko Antic, Toplica Milojevic, Mihajlo Milicevic, Aleksandar Stanimirovic, Mirjana Doknic, Dragana Miljic, Sandra Banjalic, Marija Jovanovic, Zvezdana Jemuovic, Marina Nikolic Djurovic, Danica Grujicic, Vera Popovic, Мilan Petakov
      Abstract: Hematological neoplastic mass lesions of the sellar region are rare. We identified five cases of hematological malignancy with first presentation in the sellar region from our departmental database of 1,405 patients (0.36%) with sellar lesions diagnosed over the 17-year period (2005-2021). All patients were females (mean age 55.2 ± 3.4 years). One patient had multiple myeloma (MM), one patient had acute myeloid leukemia (AML), while three other patients had lymphoma (intravascular lymphoma (IVL,...
      Citation: Endocrine journal
      PubDate: 2022-04-11
      DOI: 10.1507/endocrj.EJ21-0790
  • A case of fatal myxedema coma with electrocardiogram Osborne J-wave in a
           patient initially diagnosed with hypothyroidism

    • Authors: Masahiko Kaneko, Kentarou Ohara, Hisaharu Shikata
      Abstract: Myxedema coma is a life-threatening endocrine emergency with a high mortality rate resulting from severe insufficiency of thyroid hormones. Intravenous levothyroxine replacement is considered the standard therapy for myxedema coma in many countries. In Japan, however, although there are diagnostic criteria highly suggestive or diagnostic for myxedema coma, no management strategy has been established, despite the availability of levothyroxine. Here we report a 75-year-old man with a history of...
      Citation: Endocrine journal
      PubDate: 2022-04-11
      DOI: 10.1507/endocrj.EJ21-0720
  • Prediction model of Graves' disease in general clinical practice based on
           complete blood count and biochemistry profile

    • Authors: Ai Yoshihara, Jaeduk Yoshimura Noh, Kosuke Inoue, Junichi Taguchi, Keisuke Hata, Toru Aizawa, Yoshino Taira Arai, Natsuko Watanabe, Miho Fukushita, Masako Matsumoto, Nami Suzuki, Ayako Hoshiyama, Ai Suzuki, Takako Mitsumatsu, Aya Kinoshita, Kentaro Mikura, Ran Yoshimura, Kiminori Sugino, Koichi Ito
      Abstract: Although untreated Graves' disease (GD) is associated with a higher risk of cardiac complications and mortality, there is no well-established way to predict the onset of thyrotoxicosis in clinical practice. The aim of this study was to identify important variables that will make it possible to predict GD and thyrotoxicosis (GD + painless thyroiditis (PT)) by using a machine-learning-based model based on complete blood count and standard biochemistry profile data. We identified 19,335 newly...
      Citation: Endocrine journal
      PubDate: 2022-04-07
      DOI: 10.1507/endocrj.EJ21-0741
  • Genetic assessment using whole-exome sequencing for a young
           hypertriglyceridemic patient with repeated acute pancreatitis

    • Authors: Shingo Fujita, Hitoshi Nishizawa, Yohei Miyashita, Tasuku Imada, Takashi Yamaguchi, Takeyoshi Murano, Hideaki Bujo, Yoshihiro Asano, Junji Kozawa, Norikazu Maeda, Iichiro Shimomura
      Abstract: Hypertriglyceridemia is caused not only by environmental factors but also by genetic factors. Severe hypertriglyceridemia is prone to complications of acute pancreatitis. Here, we report a whole-exome sequencing (WES) analysis for a young hypertriglyceridemic patient with recurrent acute pancreatitis and the patient's mother. A 28-year-old hypertriglyceridemic female was admitted to our hospital. At 23 years old, a health checkup clarified her hypertriglyceridemia. At the age of 26 and 27, she...
      Citation: Endocrine journal
      PubDate: 2022-04-07
      DOI: 10.1507/endocrj.EJ22-0024
  • Increased brain-derived neurotrophic factor in the serum of persons with
           nonalcoholic fatty liver disease

    • Authors: Yuji Hattori, Hiroya Yamada, Eiji Munetsuna, Yoshitaka Ando, Genki Mizuno, Ryosuke Fujii, Yoshiki Tsuboi, Naohiro Ichino, Keisuke Osakabe, Keiko Sugimoto, Hiroaki Ishikawa, Koji Ohashi, Koji Suzuki
      Abstract: The increasing prevalence of nonalcoholic fatty liver disease (NAFLD) is a global health problem. In recent years, the inhibitory effect of brain-derived neurotrophic factor (BDNF) on diabetes mellitus and fatty liver has been clarified. The purpose of this study was to analyze the relationship between serum BDNF and NAFLD which caused by abnormal metabolism of glucose and lipids. This cross-sectional study involved 429 participants (mean age, 63.5 years: men, 38.5%) with low alcohol intake. Of...
      Citation: Endocrine journal
      PubDate: 2022-03-31
      DOI: 10.1507/endocrj.EJ21-0584
  • Associations between sex hormones and metabolic-associated fatty liver
           disease in a middle-aged and elderly community

    • Authors: Weijie Cao, Yiting Xu, Yun Shen, Yufei Wang, Xiaojing Ma, Yuqian Bao
      Abstract: Metabolic-associated fatty liver disease (MAFLD) was proposed by an international expert consensus to replace non-alcoholic fatty liver disease (NAFLD) in 2020. Previous studies have shown that sex hormones are strongly linked to NAFLD development. This study aims to explore whether sex hormones are associated with MAFLD and liver fat content (LFC) in a middle-aged and elderly community. The study included 732 subjects aged 50-80 years enrolled from communities. MAFLD was diagnosed using the...
      Citation: Endocrine journal
      PubDate: 2022-03-24
      DOI: 10.1507/endocrj.EJ21-0559
  • Urolithin A ameliorates diabetic retinopathy via activation of the
           Nrf2/HO-1 pathway

    • Authors: Zepeng Xu, Songtao Li, Kunmeng Li, Xiaoyu Wang, Xiaojie Li, Meixia An, Xiaoyi Yu, Xinguang Long, Ruiying Zhong, Qiuhong Liu, Xiaochuan Wang, Yan Yang, Ni Tian
      Abstract: Diabetic retinopathy (DR) is a progressive microvascular complication of diabetes mellitus and is characterised by excessive inflammation and oxidative stress. Urolithin A (UA), a major metabolite of ellagic acid, exerts anti-inflammatory and antioxidant functions in various human diseases. This study, for the first time, uncovered the role of UA in DR pathogenesis. Streptozotocin-induced diabetic rats were used to determine the effects of UA on blood glucose levels, retinal structures,...
      Citation: Endocrine journal
      PubDate: 2022-03-24
      DOI: 10.1507/endocrj.EJ21-0490
  • Iodide-sensitive Graves' hyperthyroidism and the strategy for resistant or
           escaped patients during potassium iodide treatment

    • Authors: Ken Okamura, Kaori Sato, Megumi Fujikawa, Sachiko Bandai, Hiroshi Ikenoue, Takanari Kitazono
      Abstract: The effectiveness of potassium iodide (KI) (100 mg/day) was evaluated in 504 untreated patients with Graves' hyperthyroidism (GD). Initial response to KI within 180 days, the effect of additional methylmercaptoimidazole (MMI) or radioactive iodine (RI) in resistant or escaped patients, and long-term prognosis were evaluated. Serum fT(4) levels became low or normal in 422 patients (83.7%, KI-sensitive group) without serious side effects. Among these patients, serum TSH levels became high (n = 92,...
      Citation: Endocrine journal
      PubDate: 2022-03-24
      DOI: 10.1507/endocrj.EJ21-0436
  • Adrenal cytomegaly with elevated serum androgen levels in a patient with
           Beckwith-Wiedemann syndrome

    • Authors: Masako Aoki, Shuichiro Uehara, Haruna Nishimaki, Ryoji Aoki, Kazunori Kayama, Nobuhiko Nagano, Tatsuhiko Urakami, Ichiro Morioka
      Abstract: Beckwith-Wiedemann syndrome (BWS) is infrequently associated with adrenocortical carcinoma (ACC) or non-hormone-producing adrenal cytomegaly, but we recently, encountered a single case of adrenal cytomegaly in a patient with BWS, which was difficult to distinguish from androgen-producing adrenocortical carcinoma (ACC). Here, we describe the case of a 4-month-old female who presented with clitoromegaly, hemihypertrophy, and an adrenal mass identified during the prenatal period. The mass was...
      Citation: Endocrine journal
      PubDate: 2022-03-24
      DOI: 10.1507/endocrj.EJ21-0261
  • Association between the duration of diabetes and gram-negative bacterial
           infection in diabetic foot infections: a case-control study

    • Authors: Siyong Chen, Xianpei Tan, Xia Li, Tongfeng Zhao
      Abstract: This retrospective case-control study was designed to explore the association between the duration of diabetes and gram-negative bacterial infection in diabetic foot infections (DFIs). All DFI patients hospitalized in the Department of Endocrinology in the Sixth Affiliated Hospital of Sun Yat-sen University between 2013 and 2019 with positive microbial culture results were included. Cases were defined as DFI patients whose microbial cultures grew gram-negative bacteria (including polymicrobial...
      Citation: Endocrine journal
      PubDate: 2022-03-24
      DOI: 10.1507/endocrj.EJ21-0690
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