Subjects -> MEDICAL SCIENCES (Total: 8196 journals)
    - ALLERGOLOGY AND IMMUNOLOGY (205 journals)
    - ANAESTHESIOLOGY (105 journals)
    - CARDIOVASCULAR DISEASES (334 journals)
    - CHIROPRACTIC, HOMEOPATHY, OSTEOPATHY (19 journals)
    - COMMUNICABLE DISEASES, EPIDEMIOLOGY (227 journals)
    - DENTISTRY (266 journals)
    - DERMATOLOGY AND VENEREOLOGY (162 journals)
    - EMERGENCY AND INTENSIVE CRITICAL CARE (121 journals)
    - ENDOCRINOLOGY (149 journals)
    - FORENSIC SCIENCES (43 journals)
    - GASTROENTEROLOGY AND HEPATOLOGY (178 journals)
    - GERONTOLOGY AND GERIATRICS (125 journals)
    - HEMATOLOGY (160 journals)
    - HYPNOSIS (4 journals)
    - INTERNAL MEDICINE (177 journals)
    - LABORATORY AND EXPERIMENTAL MEDICINE (90 journals)
    - MEDICAL GENETICS (58 journals)
    - MEDICAL SCIENCES (2241 journals)
    - NURSES AND NURSING (331 journals)
    - OBSTETRICS AND GYNECOLOGY (199 journals)
    - ONCOLOGY (355 journals)
    - OPHTHALMOLOGY AND OPTOMETRY (135 journals)
    - ORTHOPEDICS AND TRAUMATOLOGY (150 journals)
    - OTORHINOLARYNGOLOGY (76 journals)
    - PATHOLOGY (96 journals)
    - PEDIATRICS (254 journals)
    - PHYSICAL MEDICINE AND REHABILITATION (153 journals)
    - PSYCHIATRY AND NEUROLOGY (800 journals)
    - RADIOLOGY AND NUCLEAR MEDICINE (182 journals)
    - RESPIRATORY DISEASES (109 journals)
    - RHEUMATOLOGY (76 journals)
    - SPORTS MEDICINE (77 journals)
    - SURGERY (388 journals)
    - UROLOGY, NEPHROLOGY AND ANDROLOGY (151 journals)

ENDOCRINOLOGY (149 journals)                     

Showing 1 - 134 of 134 Journals sorted alphabetically
AACE Clinical Case Reports     Hybrid Journal   (Followers: 5)
Acta Diabetologica     Hybrid Journal   (Followers: 17)
Adipositas - Ursachen, Folgeerkrankungen, Therapie     Hybrid Journal   (Followers: 1)
Advances in Chronic Kidney Disease     Hybrid Journal   (Followers: 15)
Advances in Diabetes and Metabolism     Open Access   (Followers: 22)
Advances in Endocrinology     Open Access   (Followers: 7)
AJP Endocrinology and Metabolism     Hybrid Journal   (Followers: 25)
American Journal of Kidney Diseases     Hybrid Journal   (Followers: 53)
Annales d'Endocrinologie     Hybrid Journal   (Followers: 2)
Applied Physiology, Nutrition and Metabolism     Hybrid Journal   (Followers: 37)
Best Practice & Research Clinical Endocrinology & Metabolism     Hybrid Journal   (Followers: 15)
BMC Endocrine Disorders     Open Access   (Followers: 8)
Case Reports in Endocrinology     Open Access   (Followers: 3)
Clinical Diabetes     Full-text available via subscription   (Followers: 40)
Clinical Diabetes and Endocrinology     Open Access   (Followers: 20)
Clinical Endocrinology     Hybrid Journal   (Followers: 42)
Clinical Medicine Insights : Endocrinology and Diabetes     Open Access   (Followers: 29)
Clinical Nutrition Insight     Full-text available via subscription   (Followers: 13)
Clinical Reviews in Bone and Mineral Metabolism     Hybrid Journal  
Comprehensive Psychoneuroendocrinology     Open Access  
Current Opinion in Endocrine and Metabolic Research     Hybrid Journal   (Followers: 1)
Current Opinion in Endocrinology, Diabetes and Obesity     Hybrid Journal   (Followers: 48)
Dermato-Endocrinology     Open Access   (Followers: 3)
Diabesity     Open Access   (Followers: 3)
Diabetes & Metabolic Syndrome: Clinical Research & Reviews     Hybrid Journal   (Followers: 27)
Diabetes & Metabolism     Hybrid Journal   (Followers: 72)
Diabetes, Obesity and Metabolism     Hybrid Journal   (Followers: 261)
Diabetes/Metabolism Research and Reviews     Hybrid Journal   (Followers: 63)
Diabetology & Metabolic Syndrome     Open Access   (Followers: 8)
Discover Oncology     Open Access   (Followers: 1)
Domestic Animal Endocrinology     Hybrid Journal   (Followers: 6)
Dubai Diabetes and Endocrinology Journal     Open Access  
Egyptian Journal of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Endocrine     Hybrid Journal   (Followers: 11)
Endocrine and Metabolic Science     Open Access   (Followers: 1)
Endocrine Connections     Open Access   (Followers: 4)
Endocrine Disruptors     Open Access  
Endocrine Journal     Open Access   (Followers: 13)
Endocrine Pathology     Hybrid Journal   (Followers: 7)
Endocrine Practice     Hybrid Journal   (Followers: 58)
Endocrine Regulations     Open Access  
Endocrine Research     Hybrid Journal   (Followers: 3)
Endocrine Reviews     Full-text available via subscription   (Followers: 44)
Endocrine, Metabolic & Immune Disorders - Drug Targets     Hybrid Journal   (Followers: 1)
Endocrine-Related Cancer     Full-text available via subscription   (Followers: 2)
Endocrinología, Diabetes y Nutrición (English Edition)     Hybrid Journal   (Followers: 2)
Endocrinology     Full-text available via subscription   (Followers: 50)
Endocrinology and Metabolism Clinics of North America     Full-text available via subscription   (Followers: 28)
Endocrinology, Diabetes & Metabolism     Open Access  
Endocrinology, Diabetes & Metabolism Case Reports     Open Access  
Endocrinology, Obesity and Metabolic Disorders     Full-text available via subscription   (Followers: 6)
Endokrynologia Polska     Open Access   (Followers: 2)
European Journal of Endocrinology     Full-text available via subscription   (Followers: 40)
European Thyroid Journal     Full-text available via subscription   (Followers: 3)
Experimental and Clinical Endocrinology & Diabetes     Hybrid Journal   (Followers: 24)
Experimental and Clinical Endocrinology & Diabetes Reports     Open Access   (Followers: 4)
Expert Opinion on Drug Metabolism & Toxicology     Hybrid Journal   (Followers: 15)
Expert Review of Endocrinology & Metabolism     Hybrid Journal   (Followers: 7)
Frontiers in Clinical Diabetes and Healthcare     Open Access  
Frontiers in Endocrinology     Open Access   (Followers: 5)
Frontiers in Neuroendocrine Science     Open Access  
Frontiers in Neuroendocrinology     Hybrid Journal   (Followers: 10)
General and Comparative Endocrinology     Hybrid Journal   (Followers: 5)
Growth Hormone & IGF Research     Hybrid Journal   (Followers: 14)
Gynakologische Endokrinologie     Hybrid Journal  
Gynecological Endocrinology     Hybrid Journal   (Followers: 5)
Hormone and Metabolic Research     Hybrid Journal   (Followers: 16)
Hormone Research in Paediatrics     Full-text available via subscription   (Followers: 16)
Hormones : International Journal of Endocrinology and Metabolism     Hybrid Journal  
Hormones and Behavior     Hybrid Journal   (Followers: 12)
Indian Journal of Endocrinology and Metabolism     Open Access   (Followers: 4)
International Journal of Clinical Endocrinology and Metabolism     Open Access   (Followers: 1)
International journal of endocrine oncology     Open Access  
International Journal of Endocrinology     Open Access   (Followers: 3)
International Journal of Endocrinology     Open Access   (Followers: 1)
International Journal of Endocrinology and Metabolism     Open Access   (Followers: 3)
International Journal of Obesity     Hybrid Journal   (Followers: 90)
International Journal of Osteoporosis and Metabolic Disorders     Open Access   (Followers: 1)
International Journal of Pediatric Endocrinology     Open Access   (Followers: 11)
JIMD Reports     Open Access  
Journal für Gynäkologische Endokrinologie/Österreich     Hybrid Journal  
Journal für Klinische Endokrinologie und Stoffwechsel : Austrian Journal of Clinical Endocrinology and Metabolism     Hybrid Journal  
Journal of Bone and Mineral Metabolism     Hybrid Journal   (Followers: 5)
Journal of Clinical and Translational Endocrinology     Open Access  
Journal of Clinical and Translational Endocrinology Case Reports     Open Access   (Followers: 2)
Journal of Clinical Endocrinology & Metabolism     Full-text available via subscription   (Followers: 139)
Journal of Developmental Origins of Health and Disease     Hybrid Journal   (Followers: 2)
Journal of Diabetes and Endocrinology     Open Access   (Followers: 7)
Journal of Diabetes and Endocrinology Assocation of Nepal     Open Access  
Journal of Diabetes and Metabolic Disorders     Open Access   (Followers: 8)
Journal of Diabetes Science and Technology     Hybrid Journal   (Followers: 13)
Journal of Diabetology     Open Access   (Followers: 1)
Journal of Endocrinological Investigation     Full-text available via subscription   (Followers: 7)
Journal of Endocrinology     Full-text available via subscription   (Followers: 13)
Journal of Endocrinology and Metabolism     Open Access   (Followers: 5)
Journal of Endocrinology and Reproduction     Hybrid Journal  
Journal of Endocrinology, Metabolism and Diabetes of South Africa     Open Access   (Followers: 8)
Journal of Inborn Errors of Metabolism and Screening     Open Access  
Journal of Molecular Endocrinology     Full-text available via subscription   (Followers: 5)
Journal of Neuroendocrinology     Hybrid Journal   (Followers: 8)
Journal of Pineal Research     Hybrid Journal   (Followers: 1)
Journal of Renal and Hepatic Disorders     Open Access  
Journal of Restorative Medicine     Open Access  
Journal of Social Health and Diabetes     Open Access   (Followers: 1)
Journal of the ASEAN Federation of Endocrine Societies     Open Access  
Kidney International     Hybrid Journal   (Followers: 52)
Kidney Research Journal     Open Access   (Followers: 6)
L'Endocrinologo     Hybrid Journal  
Metabolic Brain Disease     Hybrid Journal   (Followers: 1)
Metabolic Syndrome and Related Disorders     Hybrid Journal   (Followers: 5)
Metabolism     Hybrid Journal   (Followers: 11)
Molecular and Cellular Endocrinology     Hybrid Journal   (Followers: 8)
Molecular Metabolism     Open Access   (Followers: 9)
Nature Reviews Endocrinology     Full-text available via subscription   (Followers: 60)
Neuroendocrinology     Full-text available via subscription   (Followers: 8)
Nigerian Endocrine Practice     Full-text available via subscription  
Nutrition in Clinical Practice     Hybrid Journal   (Followers: 43)
Open Journal of Endocrine and Metabolic Diseases     Open Access   (Followers: 1)
Psychoneuroendocrinology     Hybrid Journal   (Followers: 15)
Reproductive Biology and Endocrinology     Open Access   (Followers: 3)
Reproductive Endocrinology     Open Access   (Followers: 1)
Reviews in Endocrine and Metabolic Disorders     Hybrid Journal   (Followers: 2)
Revista Argentina de Endocrinología y Metabolismo     Open Access  
Revista Cubana de Endocrinología     Open Access  
Revista Venezolana de Endocrinología y Metabolismo     Open Access  
Sri Lanka Journal of Diabetes Endocrinology and Metabolism     Open Access  
The Endocrinologist     Full-text available via subscription   (Followers: 6)
The Lancet Diabetes and Endocrinology     Full-text available via subscription   (Followers: 167)
Therapeutic Advances in Endocrinology and Metabolism     Open Access   (Followers: 5)
Thyroid     Hybrid Journal   (Followers: 11)
Thyroid Research     Open Access   (Followers: 3)
Thyroid Research and Practice     Open Access   (Followers: 3)
Trends in Endocrinology & Metabolism     Full-text available via subscription   (Followers: 19)
Vitamins & Hormones     Full-text available via subscription   (Followers: 1)

           

Similar Journals
Journal Cover
Clinical Reviews in Bone and Mineral Metabolism
Journal Prestige (SJR): 0.405
Citation Impact (citeScore): 1
Number of Followers: 0  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1559-0119 - ISSN (Online) 1534-8644
Published by Springer-Verlag Homepage  [2469 journals]
  • Understanding the Role of Metalloproteinases and Their Inhibitors in
           Periodontology

    • Free pre-print version: Loading...

      Abstract: Periodontitis is a complex and inflammatory disorder characterized by elevated level of tissue-degrading enzymes leading to the destruction of periodontal tissue and ultimately causes loss of the tooth. Apart from standard therapeutic measures used to control periodontal infection and inflammation, matrix metalloproteinase (MMP) control plays an important role in improving outcomes of periodontal therapy. In chronic periodontitis, levels of endogenous tissue inhibitor are not sufficient to inhibit the elevated MMPs, leading to increased pathogenesis of the periodontal disease. Literature evidence revealed adjunctive tissue inhibitors of metalloproteinases (TIMPs) play a pivotal role in managing chronic periodontitis. Recently, a large number of products including collagen, peptidomimetics, non-peptidomimetics, tetracycline, chemically modified tetracycline, and bisphosphonates are being investigated as MMP inhibitors to improve outcomes in periodontal therapy. This review aims to analyze the role of MMPs in periodontitis and summarizes the therapeutic application of TIMPs that could help in selecting an appropriate adjunct to periodontal therapy for better outcomes. Graphic
      PubDate: 2022-01-04
      DOI: 10.1007/s12018-021-09281-y
       
  • The Distraction Osteogenesis Callus: a Review of the Literature

    • Free pre-print version: Loading...

      Abstract: Abstract The distraction osteogenesis has been an integrated treatment approach in significant bone deficiencies resulting from debridement or high-energy trauma. Nevertheless, it usually demands a prolonged treatment period attributed to the more profound distraction osteogenesis callus physiology. This distraction callus is a tissue not naturally present in mammals and results after surgical intervention. Despite sharing quite similar molecular and biomechanical mechanisms to the fracture-healing callus, it recruits unique physiological pathways. This review presents the deep physiology of the distraction osteogenesis callus, the familiar pathways with the fracture healing callus, and current maturation’s acceleration tactic concepts.
      PubDate: 2022-01-04
      DOI: 10.1007/s12018-021-09282-x
       
  • Correction to: Periodontitis and Rheumatoid Arthritis: The Common Thread

    • Free pre-print version: Loading...

      Abstract: Abstract The two immunoinflammatory disorders, rheumatoid arthritis (RA) and Periodontitis (PD) are characterized by synovitis, joint damage, and alveolar bone degradation, are triggered by certain inflammatory mediators and leukocyte invasion, respectively. Rheumatoid arthritis is an infectious disorder which attacks changed self-epitopes and thus affects 1% of the human population, whereas 11% of the worldwide population aged is afflicted by extreme periodontal diseases in which commensal microbes upon the tooth surface is substituted by dysbiosis of the bacterial community that facilitate chronic inflammatory periodontal tissue damage. Periodontitis and RA display similarities in terms of pathogenesis amid variations in aetiology; all diseases entail systemic inflammation fuelled by, degradation of connective tissue, pro-inflammatory cytokines, and bone deterioration. Both the disorders have significant serological, epidemiological, and therapeutic connections and also have some common risk factors like aging and smoking. Laboratory and clinical data supporting this correlation is addressed in this aetiology analysis and the possible pathways involved in connecting both the diseases i.e., periodontitis to RA are described.
      PubDate: 2021-12-14
      DOI: 10.1007/s12018-021-09280-z
       
  • Effect of Oxidative Stress on Bone Remodeling in Periprosthetic Osteolysis

    • Free pre-print version: Loading...

      Abstract: Abstract The success of implant performance and arthroplasty is based on several factors, including oxidative stress-induced osteolysis. Oxidative stress is a key factor of the inflammatory response. Implant biomaterials can release wear particles which may elicit adverse reactions in patients, such as local inflammatory response leading to tissue damage, which eventually results in loosening of the implant. Wear debris undergo phagocytosis by macrophages, inducing a low-grade chronic inflammation and reactive oxygen species (ROS) production. In addition, ROS can also be directly produced by prosthetic biomaterial oxidation. Overall, ROS amplify the inflammatory response and stimulate both RANKL-induced osteoclastogenesis and osteoblast apoptosis, resulting in bone resorption, leading to periprosthetic osteolysis. Therefore, a growing understanding of the mechanism of oxidative stress-induced periprosthetic osteolysis and anti-oxidant strategies of implant design as well as the addition of anti-oxidant agents will help to improve implants’ performances and therapeutic approaches.
      PubDate: 2021-08-03
      DOI: 10.1007/s12018-021-09278-7
       
  • Making Sense of the Highly Variable Effects of Alcohol on Bone

    • Free pre-print version: Loading...

      Abstract: Abstract Alcohol consumption is often reported to influence bone health in a dose-dependent manner where moderate alcohol intake is deemed beneficial and heavy drinking detrimental. However, this relationship may not be valid for individual alcohol consumers, as small quantities of alcohol can have detrimental skeletal effects and not all studies report clinically relevant bone loss with long-duration alcohol abuse. These discrepant findings suggest that factors beyond quantity of alcohol consumed contribute to the observed skeletal response. We propose that the interplay between intrinsic factors (e.g., age, sex, skeletal site) and extrinsic factors (e.g., age of onset of drinking, duration of drinking, comorbidities) influence the precise impact of alcohol consumption on bone health. In this review, we summarize literature reporting the effects of alcohol on the human skeleton. Based on the finding that alcohol alters the circulating levels of dozens of peptides shown to influence bone metabolism, we arrive at the conclusion that no single unifying mechanism adequately explains the diversity of reports or successfully predicts individuals most likely to be impacted favorably or unfavorably by alcohol consumption. We propose that a more holistic approach—in which drinking pattern and intrinsic factors are accounted for—is required to better understand and respond to the end-organ effects of alcohol on the skeleton.
      PubDate: 2021-07-31
      DOI: 10.1007/s12018-021-09277-8
       
  • Bone Metabolism in SARS-CoV-2 Disease: Possible Osteoimmunology and Gender
           Implications

    • Free pre-print version: Loading...

      Abstract: Abstract Even though inflammatory conditions are known to exert adverse effects on bone metabolism, there are no published data regarding SARS-CoV-2 infection and subsequent fracture risk. We present a brief review of the molecular mechanisms linking inflammatory diseases to increased fracture risk/osteoporosis and of the therapeutic strategies that can prevent bone resorption in patients with inflammatory disease, focusing on the RANK-RANKL system. We also make some considerations on gender differences in infection response and on their implications for survival and for the consequences of COVID-19. Several inflammatory cytokines, especially IL-1, IL-6, and TNF-α, stimulate osteoclast activity, favoring bone resorption through the RANK-RANKL system. Data from the previous SARS-CoV outbreak suggest that the present disease also has the potential to act directly on bone resorption units, although confirmation is clearly needed. Even though the available data are limited, the RANK-RANKL system may provide the best therapeutic target to prevent bone resorption after COVID-19 disease. Vitamin D supplementation in case of deficiency could definitely be beneficial for bone metabolism, as well as for the immune system. Supplementation of vitamin D in case of deficiency could be further advantageous. In COVID-19 patients, it would be useful to measure the bone metabolism markers and vitamin D. Targeting the RANK-RANKL system should be a priority, and denosumab could represent a safe and effective choice. In the near future, every effort should be made to investigate the fracture risk after SARS-CoV-2 infection.
      PubDate: 2020-12-01
      DOI: 10.1007/s12018-020-09274-3
       
  • Adipokines and Chronic Rheumatic Diseases: from Inflammation to Bone
           Involvement

    • Free pre-print version: Loading...

      Abstract: Abstract Besides its well-known role as energy storage tissue, adipose tissue is a biologically active tissue that can also be considered as an endocrine organ, as it is able to secrete adipokines. These bioactive factors, similar in structure to cytokines, are involved in several physiological and pathological conditions, such as glucose homeostasis, angiogenesis, blood pressure regulation, control of food intake, and also inflammation and bone homeostasis via endocrine, paracrine, and autocrine mechanisms. Given their pleiotropic functions, the role of adipokines has been evaluated in chronic rheumatic osteoarticular inflammatory diseases, particularly focusing on their effects on inflammatory and immune response and on bone alterations. Indeed, these diseases are characterized by different bone complications, such as local and systemic bone loss and new bone formation. The aim of this review is to summarize the role of adipokines in rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, osteoarthritis, and osteoporosis, especially considering their role in the pathogenesis of bone complications typical of these conditions.
      PubDate: 2020-12-01
      DOI: 10.1007/s12018-021-09275-w
       
  • Towards a Standard Approach to Assess Tibial Bone Loss Following Total
           Knee Arthroplasty

    • Free pre-print version: Loading...

      Abstract: Abstract Long-term implant failure in the form of aseptic loosening and periprosthetic fracture is the most common cause of revision procedures in total knee arthroplasty (TKA). While early loosening can often be attributed to failure of primary fixation, late implant failure could be associated with loss of fixation secondary to bone resorption, as a result of stress shielding in the proximal tibia. This current review study was performed to identify the clinical effects of different implant-, patient-, and surgery-related biomechanical factors on TKA-related tibial bone loss in clinical reality. Implant-related factors considered were the fixation method, and the implant type, geometry, and stiffness. In terms of patient characteristics, the effects of age, sex, knee alignment, bone density, body weight, and activity level were analyzed. The clinical literature on these topics mostly concerned longitudinal radiographic studies investigating the effect of a single factor on changes in the proximal tibia over time using bone densitometry. Implant stiffness, implant geometry and knee alignment were the only factors consistently found to affect regional bone density changes over time. Each clinical study used its own specific study design, with different definitions used for the baseline density, time points of baseline and follow-up measurements, and regions of interest. Due to the differences in study design, direct comparison between the clinical impact of different biomechanical factors was not possible. Based on the findings over the densitometry studies, a standardized guideline was proposed to allow reliable comparison between consistently reported outcome of future radiographic TKA studies.
      PubDate: 2020-12-01
      DOI: 10.1007/s12018-021-09276-9
       
  • Insights into the Perspective Correlation Between Vitamin D and Regulation
           of Hormones: Thyroid and Parathyroid Hormones

    • Free pre-print version: Loading...

      Abstract: Abstract Vitamin D is a vital contributor to the regulation of calcium and phosphorus homeostasis to preserve healthy bones and teeth. This was previously assumed as the only role of vitamin D, but the amount of recent studies gives it popularity as panacea for cases beyond bone mineralization especially after reporting vitamin D receptors in many human cells. This led to a growing evidence that vitamin D could have a greater effect on human health. Accordingly, several functions of vitamin D have been agreed, and in several disorders, its deficiency is crucially suggested. Current reports have also demonstrated a striking link between vitamin D and the regulation of hormones with illustrated role for vitamin D in stimulation or inhibition of the synthesis and release of different hormones, as well as the feedback of some hormones on the in vivo production of vitamin D. A variety of conditions may arise as a consequence of increased or even decreased secretion of hormones have been linked to low level of serum vitamin D, providing a significance for reviewing of this regulation biologically and physiologically. This review is the first part of series to highlight the correlation between vitamin D and regulation of hormones in addition to reporting the link between deficiency of vitamin D and the hormone-associated medical disorders. Vitamin D’s role in regulation of hormone secretion and its associations with thyroid and parathyroid hormones will be considered in the current review.
      PubDate: 2020-12-01
      DOI: 10.1007/s12018-021-09279-6
       
  • Periodontitis and Rheumatoid Arthritis: the Common Thread

    • Free pre-print version: Loading...

      Abstract: Abstract Periodontitis (PD) and rheumatoid arthritis (RA) are immuno-inflammatory diseases where leukocyte infiltration and inflammatory mediators induce alveolar bone loss, synovitis and joint destruction, respectively. One percent of the human population is affected by RA which is an autoimmune disease that target modified self-epitopes while 11% of the global adult population are affected by severe chronic periodontitis in which commensal microflora on the tooth surface is replaced by a dysbiotic consortium of bacteria that promote the chronic inflammatory destruction of periodontal tissue. Despite differences in aetiology, RA and periodontitis show similarity in terms of pathogenesis; both diseases involve chronic inflammation fuelled by pro-inflammatory cytokines, connective tissue breakdown and bone erosion. The two diseases also share risk factors such as smoking and ageing and have strong epidemiological, serological and clinical associations. In this review aetiology, clinical and experimental evidence supporting this association is discussed and the potential mechanisms involved in linking periodontitis to RA are presented.
      PubDate: 2020-09-01
      DOI: 10.1007/s12018-020-09271-6
       
  • Current and Emerging Therapies for Pediatric Bone Diseases

    • Free pre-print version: Loading...

      Abstract: Abstract Most pediatric bone diseases result either from mutations of the essential genes for bone development or from abnormalities of mineral homeostasis. With an increase in non-invasive techniques to measure bone mineral density, the number of children with apparent low bone mineral density is rising. Furthermore, a new classification system proposed by the International Society for Clinical Densitometry now considers osteoporosis a valid diagnosis in children. Osteoporosis is a particular problem among children with conditions such as muscular dystrophy, immobilization, and chronic liver diseases and those who received a prolonged course of glucocorticoids. Pharmacologic agents for treatment of osteoporosis were developed primarily to prevent fragility fractures in postmenopausal women, and studies of their efficacy and safety in children are limited. Recent advances have seen new therapies for bone diseases in children; some of these conditions were deemed incurable in the past. This article reviews data regarding mechanism of action, safety, and efficacy of four bone drugs in pediatric patients. These are (1) zoledronic acid, a long-acting bisphosphonate; (2) denosumab, a RANKL inhibitor; (3) asfotase alfa, a synthetic alkaline phosphatase; and (4) burosumab, a monoclonal antibody against FGF23.
      PubDate: 2020-09-01
      DOI: 10.1007/s12018-020-09272-5
       
  • Type 2 Diabetes Mellitus and Osteoarthritis: the Role of Glucose
           Transporters

    • Free pre-print version: Loading...

      Abstract: Abstract Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are the most common chronic diseases worldwide. Previous studies indicate the involvement of glucose transporters (GLUTs) in the development of OA induced by diabetes—specifically, the increased glucose level inside the cell and its positive effect on cytokines’ or AGE receptors’ activity. Thus, a study was conducted to investigate whether T2DM increases the chance of developing OA and what role GLUTs play in causing this disease. To identify the research question in this scoping review, a preliminary search was carried out in the PubMed database, looking at studies of T2DM and OA and their association with GLUTs. Searches for articles in English were carried out in the PubMed database. The search components were first evaluated using a MeSH term system. The search terms were divided into three groups: T2DM, OA, and GLUT. After removing duplicates from the original search (n = 3252), 864 studies were retrieved for the screening stage. A total of 104 studies were included in the selection phase, and, in the end, 36 studies were eligible. According to the studies, four themes—T2DM and GLUTs, OA and GLUTs, T2DM and OA, and T2DM and OA and GLUTs—were found to classify the findings. In conclusion, GLUT-1 composition in the plasma membrane of articular cell and chondrocyte increases glucose uptake in hyperglycemic conditions. This event leads to increased levels of inflammatory cytokines—such as IL-1β, TGF-β1, and MMP—oxidative stress, and AGEs. Therefore, these alterations induce the deleterious effects of glucotoxicity at the joint surface, which ultimately leads to OA.
      PubDate: 2020-09-01
      DOI: 10.1007/s12018-020-09270-7
       
  • Can Periodontal Disease Be Considered Linked to Obesity and
           Lipoinflammation' Mechanisms Involved in the Pathogenesis Occurrence

    • Free pre-print version: Loading...

      Abstract: Abstract Obesity is a systemic disease, associated with an increased risk of cardiovascular disorders, type 2 diabetes, cancer, asthma, and osteoarthritis. Overweight and obesity have been suggested to be associated with periodontitis as published in studies and narrative summaries. Obesity and periodontal diseases are very prevalent in the world, and both can lead to severe chronic health conditions and impair people’s life quality. Knowledge of how immune mechanisms and inflammatory responses are regulated is critical for understanding the pathogenesis of complex diseases, such as periodontitis. In conditions of overweight, it has been demonstrated that approximately 70–80% of individuals present an adipose tissue turnover that is both structurally and functionally causing of the systemic inflammatory reaction. The objective of this review is to explore the influence of lipoinflammation. The effects of lipoinflammation and obesity on development of periodontal disease are reported together with the exploration of the mechanisms of interaction between these two diseases.
      PubDate: 2020-09-01
      DOI: 10.1007/s12018-020-09273-4
       
  • X-linked Hypophosphatemic Rickets: the Challenges of Treatment

    • Free pre-print version: Loading...

      Abstract: Abstract X-linked dominant hypophosphatemic rickets (XLHR) is the most common inherited form of rickets due to a mutation in the phosphate regulating gene with homologies to endopeptidases on the X chromosome (PHEX gene) expressed in bones and teeth. This leads to impaired renal reabsorption of phosphate and defective bone mineralization. Clinical presentation often occurs in childhood, where children mostly present with bow legs, delayed walking, or gait difficulties. Other clinical features may also be present and these are described in this review in addition to the classic laboratory findings. Focus is made on the management of XLHR and its challenges, highlighting the complications that may arise from medical treatment with reference to literature. Moreover, we also describe novel treatment in XLHR; the potential use of growth hormone and cinacalcet, and the newly approved human monoclonal antibody against FGF-23 as a more targeted therapy.
      PubDate: 2019-12-01
      DOI: 10.1007/s12018-019-09266-y
       
  • Bone Metabolism in Inflammatory Bowel Disease and Celiac Disease

    • Free pre-print version: Loading...

      Abstract: Abstract Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitecture deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. Several gastrointestinal disorders have been associated with osteoporosis including inflammatory bowel disease and celiac disease. Different factors can explain low bone density and fractures in these patients.
      PubDate: 2019-12-01
      DOI: 10.1007/s12018-019-09269-9
       
  • Current and Emerging Pharmacotherapy for Gaucher Disease

    • Free pre-print version: Loading...

      Abstract: Abstract Gaucher disease (GD) is the most common inherited lysosomal storage disorder. It is a multi-system disease secondary a deficient activity of glucocerebrosidase-β-acid by variants in the GBA gene. The wide variability in the severity of clinical manifestations causes it to be diagnosed at any age. Only about 30% of patients are identified to have it in their childhood. Leaving aside the most serious forms of the diseases that are observed in the first weeks of life, most of the manifestations focus on the increase of visceral size, cytopenias, growth retardation, and bone pain crisis. The introduction of enzymatic replacement therapy (ERT) 28 years ago was a revolution and a change in the treatment landscape of GD, the eradication of splenectomy, and the reduction of bone complications when ERT begins in childhood has been definitive for the control of the disease and improvement of the quality of life. The treatment is effective in most patients without neurological involvement and with few adverse effects; however, the need for an intravenous administration every 2 weeks, indefinitely, not having the property to cure the disease has motivated the search for more alternatives that are comfortable, effective, and definitive.
      PubDate: 2019-12-01
      DOI: 10.1007/s12018-019-09267-x
       
  • Socio-economic Determinants of Bone Health from Past to Present

    • Free pre-print version: Loading...

      Abstract: Abstract Increasing epidemiology evidence amounts for social determinants of bone health underlying musculo-skeletal conditions such as osteoporosis. Amongst different facets influencing skeletal health, socio-economic status (SES) has been identified as a critical factor determining one’s access to resources, health care, education, nutrition, and physical activity. Recent conceptual and epigenetic studies assessing SES links with DNA methylation offer further support for the adverse effects of social disadvantage in early life on bone quantity and quality in adulthood. However, this evidence for socially patterned risks in bone fragility is not restricted to the contemporary society. Data exist for ancient human skeletal samples deriving from SES stratified cemeteries that also reflect bone changes consistent with lifestyles specific to social standing. Similarly to modern data, the conclusion drawn from the ancient times has been for a negative effect of low SES on bone growth and maintenance. Some contradictory results, mirroring previously reported inconsistencies in epidemiological studies, have also been reported showing that high SES can equally result in poor bone health. It becomes clear that ancient perspectives can offer a further line of support into these ongoing epidemiological and epigenetic research efforts. Taken together, a holistic approach to clinical understanding and practice of bone health is recommended, building upon ancient and modern findings to target living groups who are most at risk of developing low bone mass and compromised bone micro-architecture.
      PubDate: 2019-12-01
      DOI: 10.1007/s12018-019-09263-1
       
  • Bone Health and BMD Research in Pediatric and Adolescent Individuals with
           ASD: Current Data, Evaluation, and Next Steps

    • Free pre-print version: Loading...

      Abstract: Abstract Austin spectrum disorder (ASD) is a complex neurodevelopmental disorder that can include impairments in communication skills and social interaction as well as behavioral challenges. Recent research has evaluated bone health and bone mineral density (BMD) in cohorts of pediatric, adolescent, and young adult participants. Consistent findings across publications indicate that individuals with ASD have decreased BMD when compared to non-ASD age-matched peers. Factors raised in the literature for consideration of impact on BMD status include dietary intake, feeding behavior, nutrient status, gastrointestinal (GI) symptoms and diagnoses, physical activity, and prescription medication usage. This review aims to provide a comprehensive overview of published research evaluating BMD in those with ASD, analyze potential issues of correlation with lowered BMD in this population, offer perspective for future research consideration, and propose evaluation and intervention strategies to address and potentially ameliorate both the short-term and long-term impact of decreased BMD in children and adolescents.
      PubDate: 2019-12-01
      DOI: 10.1007/s12018-019-09268-w
       
  • Skeletal Changes Associated with Osteoarthritis

    • Free pre-print version: Loading...

      Abstract: Abstract Osteoarthritis (OA) is a degenerative joint disorder in which progressive articular cartilage loss occurs alongside pathological changes in subchondral bone and other joint tissues. The pathophysiological role of bone in OA has been a point of interest for many years and has resurfaced again in recent years as a potential target for new treatments. Articular cartilage and subchondral bone together form the osteochondral unit. Its homeostasis and integrity are reliant on biochemical crosstalk and biomechanical interplay between the two. Subchondral bone, with its relatively greater stiffness and strength, provides mechanical support to the overlying cartilage and absorbs much of the mechanical force transmitted through the joint. Mechanical instability in osteoarthritic joints is thought to be a significant risk-factor in joint disease, due to the mechano-sensitive nature of many of its native tissues. Although the progression of joint disease remains incompletely understood, significant changes in subchondral bone remodelling, structure, composition, and mechanical properties have been documented in animal and human studies of OA. The purpose of this review is to explore and discuss these bony changes associated with disease and, in particular, contextualise the basic science and clinical literature on the role of subchondral bone in OA.
      PubDate: 2019-12-01
      DOI: 10.1007/s12018-019-09264-0
       
  • Comparison of Efficacy of Pharmacologic Treatments in Pregnancy- and
           Lactation-Associated Osteoporosis

    • Free pre-print version: Loading...

      Abstract: Abstract Pregnancy- and lactation-associated osteoporosis (PLO) is a rare disorder characterised by the occurrence of multiple fragility fractures, particularly at vertebral columns, in the third trimester or early postpartum period. Whether implementation for pharmacologic treatments in patients with PLO remains controversial partly due to rarity of data and known indolent recovery of bone mass after fracture, various pharmacologic treatments have been reported to effectively facilitate bone mineral density (BMD) increase in anecdotal case reports or cohorts based on individualised clinical assessment of subsequent fracture risk. In this study, we aimed to summarise pharmacologic strategies and its efficacy on BMD change and subsequent fractures using individual case data or frequency-weighted group data from available literatures. Among 2438 studies identified using PubMed and Embase until Jan 2019, 30 studies which reported pharmacologic treatment (23 studies) or observation (7 studies) were included. Reported treatment options consisted of observation with calcium/vitamin D supplements (control, n = 32), bisphosphonates (BP, n = 31), teriparatide (TPTD, n = 40) and other strategies (vitamin K2 and strontium; other, n = 4). Median treatment duration and BMD follow-up duration was 27 and 35 months, respectively. Mean lumbar spine BMD measured by dual-energy x-ray absorptiometry was increased at 3-year follow-up in all groups (control, 7.9%; BP, 18.2%; TPTD, 17.0%; other, 8.6%; P < 0.05 for all), with significantly higher BMD change in BP or TPTD compared to control (Bonferroni-corrected P < 0.001 for all). Our findings suggest the potential long-term efficacy of pharmacologic treatments in individuals with PLO with high risk of subsequent fracture.
      PubDate: 2019-06-01
      DOI: 10.1007/s12018-019-09262-2
       
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
 


Your IP address: 35.168.110.128
 
Home (Search)
API
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-