Subjects -> MEDICAL SCIENCES (Total: 8196 journals)
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ENDOCRINOLOGY (149 journals)                     

Showing 1 - 134 of 134 Journals sorted alphabetically
AACE Clinical Case Reports     Hybrid Journal   (Followers: 5)
Acta Diabetologica     Hybrid Journal   (Followers: 17)
Adipositas - Ursachen, Folgeerkrankungen, Therapie     Hybrid Journal   (Followers: 1)
Advances in Chronic Kidney Disease     Hybrid Journal   (Followers: 15)
Advances in Diabetes and Metabolism     Open Access   (Followers: 22)
Advances in Endocrinology     Open Access   (Followers: 7)
AJP Endocrinology and Metabolism     Hybrid Journal   (Followers: 25)
American Journal of Kidney Diseases     Hybrid Journal   (Followers: 53)
Annales d'Endocrinologie     Hybrid Journal   (Followers: 2)
Applied Physiology, Nutrition and Metabolism     Hybrid Journal   (Followers: 37)
Best Practice & Research Clinical Endocrinology & Metabolism     Hybrid Journal   (Followers: 15)
BMC Endocrine Disorders     Open Access   (Followers: 8)
Case Reports in Endocrinology     Open Access   (Followers: 3)
Clinical Diabetes     Full-text available via subscription   (Followers: 40)
Clinical Diabetes and Endocrinology     Open Access   (Followers: 20)
Clinical Endocrinology     Hybrid Journal   (Followers: 42)
Clinical Medicine Insights : Endocrinology and Diabetes     Open Access   (Followers: 29)
Clinical Nutrition Insight     Full-text available via subscription   (Followers: 13)
Clinical Reviews in Bone and Mineral Metabolism     Hybrid Journal  
Comprehensive Psychoneuroendocrinology     Open Access  
Current Opinion in Endocrine and Metabolic Research     Hybrid Journal   (Followers: 1)
Current Opinion in Endocrinology, Diabetes and Obesity     Hybrid Journal   (Followers: 48)
Dermato-Endocrinology     Open Access   (Followers: 3)
Diabesity     Open Access   (Followers: 3)
Diabetes & Metabolic Syndrome: Clinical Research & Reviews     Hybrid Journal   (Followers: 27)
Diabetes & Metabolism     Hybrid Journal   (Followers: 72)
Diabetes, Obesity and Metabolism     Hybrid Journal   (Followers: 261)
Diabetes/Metabolism Research and Reviews     Hybrid Journal   (Followers: 63)
Diabetology & Metabolic Syndrome     Open Access   (Followers: 8)
Discover Oncology     Open Access   (Followers: 1)
Domestic Animal Endocrinology     Hybrid Journal   (Followers: 6)
Dubai Diabetes and Endocrinology Journal     Open Access  
Egyptian Journal of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Endocrine     Hybrid Journal   (Followers: 11)
Endocrine and Metabolic Science     Open Access   (Followers: 1)
Endocrine Connections     Open Access   (Followers: 4)
Endocrine Disruptors     Open Access  
Endocrine Journal     Open Access   (Followers: 13)
Endocrine Pathology     Hybrid Journal   (Followers: 7)
Endocrine Practice     Hybrid Journal   (Followers: 58)
Endocrine Regulations     Open Access  
Endocrine Research     Hybrid Journal   (Followers: 3)
Endocrine Reviews     Full-text available via subscription   (Followers: 44)
Endocrine, Metabolic & Immune Disorders - Drug Targets     Hybrid Journal   (Followers: 1)
Endocrine-Related Cancer     Full-text available via subscription   (Followers: 2)
Endocrinología, Diabetes y Nutrición (English Edition)     Hybrid Journal   (Followers: 2)
Endocrinology     Full-text available via subscription   (Followers: 50)
Endocrinology and Metabolism Clinics of North America     Full-text available via subscription   (Followers: 28)
Endocrinology, Diabetes & Metabolism     Open Access  
Endocrinology, Diabetes & Metabolism Case Reports     Open Access  
Endocrinology, Obesity and Metabolic Disorders     Full-text available via subscription   (Followers: 6)
Endokrynologia Polska     Open Access   (Followers: 2)
European Journal of Endocrinology     Full-text available via subscription   (Followers: 40)
European Thyroid Journal     Full-text available via subscription   (Followers: 3)
Experimental and Clinical Endocrinology & Diabetes     Hybrid Journal   (Followers: 24)
Experimental and Clinical Endocrinology & Diabetes Reports     Open Access   (Followers: 4)
Expert Opinion on Drug Metabolism & Toxicology     Hybrid Journal   (Followers: 15)
Expert Review of Endocrinology & Metabolism     Hybrid Journal   (Followers: 7)
Frontiers in Clinical Diabetes and Healthcare     Open Access  
Frontiers in Endocrinology     Open Access   (Followers: 5)
Frontiers in Neuroendocrine Science     Open Access  
Frontiers in Neuroendocrinology     Hybrid Journal   (Followers: 10)
General and Comparative Endocrinology     Hybrid Journal   (Followers: 5)
Growth Hormone & IGF Research     Hybrid Journal   (Followers: 14)
Gynakologische Endokrinologie     Hybrid Journal  
Gynecological Endocrinology     Hybrid Journal   (Followers: 5)
Hormone and Metabolic Research     Hybrid Journal   (Followers: 16)
Hormone Research in Paediatrics     Full-text available via subscription   (Followers: 16)
Hormones : International Journal of Endocrinology and Metabolism     Hybrid Journal  
Hormones and Behavior     Hybrid Journal   (Followers: 12)
Indian Journal of Endocrinology and Metabolism     Open Access   (Followers: 4)
International Journal of Clinical Endocrinology and Metabolism     Open Access   (Followers: 1)
International journal of endocrine oncology     Open Access  
International Journal of Endocrinology     Open Access   (Followers: 3)
International Journal of Endocrinology     Open Access   (Followers: 1)
International Journal of Endocrinology and Metabolism     Open Access   (Followers: 3)
International Journal of Obesity     Hybrid Journal   (Followers: 90)
International Journal of Osteoporosis and Metabolic Disorders     Open Access   (Followers: 1)
International Journal of Pediatric Endocrinology     Open Access   (Followers: 11)
JIMD Reports     Open Access  
Journal für Gynäkologische Endokrinologie/Österreich     Hybrid Journal  
Journal für Klinische Endokrinologie und Stoffwechsel : Austrian Journal of Clinical Endocrinology and Metabolism     Hybrid Journal  
Journal of Bone and Mineral Metabolism     Hybrid Journal   (Followers: 5)
Journal of Clinical and Translational Endocrinology     Open Access  
Journal of Clinical and Translational Endocrinology Case Reports     Open Access   (Followers: 2)
Journal of Clinical Endocrinology & Metabolism     Full-text available via subscription   (Followers: 139)
Journal of Developmental Origins of Health and Disease     Hybrid Journal   (Followers: 2)
Journal of Diabetes and Endocrinology     Open Access   (Followers: 7)
Journal of Diabetes and Endocrinology Assocation of Nepal     Open Access  
Journal of Diabetes and Metabolic Disorders     Open Access   (Followers: 8)
Journal of Diabetes Science and Technology     Hybrid Journal   (Followers: 13)
Journal of Diabetology     Open Access   (Followers: 1)
Journal of Endocrinological Investigation     Full-text available via subscription   (Followers: 7)
Journal of Endocrinology     Full-text available via subscription   (Followers: 13)
Journal of Endocrinology and Metabolism     Open Access   (Followers: 5)
Journal of Endocrinology and Reproduction     Hybrid Journal  
Journal of Endocrinology, Metabolism and Diabetes of South Africa     Open Access   (Followers: 8)
Journal of Inborn Errors of Metabolism and Screening     Open Access  
Journal of Molecular Endocrinology     Full-text available via subscription   (Followers: 5)
Journal of Neuroendocrinology     Hybrid Journal   (Followers: 8)
Journal of Pineal Research     Hybrid Journal   (Followers: 1)
Journal of Renal and Hepatic Disorders     Open Access  
Journal of Restorative Medicine     Open Access  
Journal of Social Health and Diabetes     Open Access   (Followers: 1)
Journal of the ASEAN Federation of Endocrine Societies     Open Access  
Kidney International     Hybrid Journal   (Followers: 52)
Kidney Research Journal     Open Access   (Followers: 6)
L'Endocrinologo     Hybrid Journal  
Metabolic Brain Disease     Hybrid Journal   (Followers: 1)
Metabolic Syndrome and Related Disorders     Hybrid Journal   (Followers: 5)
Metabolism     Hybrid Journal   (Followers: 11)
Molecular and Cellular Endocrinology     Hybrid Journal   (Followers: 8)
Molecular Metabolism     Open Access   (Followers: 9)
Nature Reviews Endocrinology     Full-text available via subscription   (Followers: 60)
Neuroendocrinology     Full-text available via subscription   (Followers: 8)
Nigerian Endocrine Practice     Full-text available via subscription  
Nutrition in Clinical Practice     Hybrid Journal   (Followers: 43)
Open Journal of Endocrine and Metabolic Diseases     Open Access   (Followers: 1)
Psychoneuroendocrinology     Hybrid Journal   (Followers: 15)
Reproductive Biology and Endocrinology     Open Access   (Followers: 3)
Reproductive Endocrinology     Open Access   (Followers: 1)
Reviews in Endocrine and Metabolic Disorders     Hybrid Journal   (Followers: 2)
Revista Argentina de Endocrinología y Metabolismo     Open Access  
Revista Cubana de Endocrinología     Open Access  
Revista Venezolana de Endocrinología y Metabolismo     Open Access  
Sri Lanka Journal of Diabetes Endocrinology and Metabolism     Open Access  
The Endocrinologist     Full-text available via subscription   (Followers: 6)
The Lancet Diabetes and Endocrinology     Full-text available via subscription   (Followers: 167)
Therapeutic Advances in Endocrinology and Metabolism     Open Access   (Followers: 5)
Thyroid     Hybrid Journal   (Followers: 11)
Thyroid Research     Open Access   (Followers: 3)
Thyroid Research and Practice     Open Access   (Followers: 3)
Trends in Endocrinology & Metabolism     Full-text available via subscription   (Followers: 19)
Vitamins & Hormones     Full-text available via subscription   (Followers: 1)

           

Similar Journals
Journal Cover
Clinical Medicine Insights : Endocrinology and Diabetes
Journal Prestige (SJR): 0.63
Citation Impact (citeScore): 2
Number of Followers: 29  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1179-5514
Published by Sage Publications Homepage  [1174 journals]
  • Barriers and Strategies for Type 1 Diabetes Management Among Emerging
           Adults: A Qualitative Study

    • Authors: Bailee Sawyer, Elizabeth Hilliard, Kyle J Hackney, Sherri Stastny
      Abstract: Clinical Medicine Insights: Endocrinology and Diabetes, Volume 15, Issue , January-December 2022.
      Purpose:Individuals in the emerging adult age group (18-30 years) with type 1 diabetes (T1DM) have unique medical and social needs. The purpose of this study was to observe barriers and strategies for diabetes management among emerging adults with T1DM.Methods:A qualitative grounded theory model was utilized. An open-ended approach with a telephone interview was designed to allow a deeper understanding of the T1DM experience. The participants were from a larger survey-volunteer participant group and were asked to complete 1 interview in spring 2020 (n = 21, diagnosed age: mean 15.00 ± 8.00, females, n = 19). The data were analyzed for cohesive themes using grounded theory.Results:Participants indicated three main barrier themes (physiology, environment, and insurance) and 3 barrier subthemes (mental health, lack of social support, and weather). Three main strategy themes to diabetes management were recognized (medical technology, access to social support, and physical activity). There were 2 strategy subthemes (social media and social accountability).Conclusions:Regular use of social media can be a key tool for social accountability while lack of social support and physiological shifts can be barriers to management of T1DM. Physical activity should be considered as part of an individualized plan for management of diabetes.
      Citation: Clinical Medicine Insights: Endocrinology and Diabetes
      PubDate: 2022-05-21T07:03:38Z
      DOI: 10.1177/11795514221098389
      Issue No: Vol. 15 (2022)
       
  • Insulin Resistance in Gestational Diabetes Mellitus and Its Association
           With Anthropometric Fetal Indices

    • Authors: Tuan Dinh Le, Tien Minh Bui, Trinh Hien Vu, Nga Phi Thi Nguyen, Hoa Thanh Thi Tran, Son Tien Nguyen, Lan Ho Thi Nguyen, Manh Van Ngo, Hoang Huy Duong, Binh Thanh Vu, Hoa Trung Dinh, Binh Nhu Do, Duc-Cuong Le, Hien Thi Nguyen, Kien Trung Nguyen
      Abstract: Clinical Medicine Insights: Endocrinology and Diabetes, Volume 15, Issue , January-December 2022.
      Background:In pregnant women with gestational diabetes mellitus (GDM), insulin resistance (IR) increases the risk of developing manifest type 2 diabetes mellitus and is associated with complications in both mother and fetus.Objectives:This research aimed to evaluate the associations between IR evaluated by 3 indices (namely updated homeostasis model assessment model (HOMA2), QUICKI, and McAuley’s index) and the diabetes risk factors and the fetal growth indices in Vietnamese women with GDM.Methods:A cross-sectional descriptive study was conducted on 370 women with GDM and 40 healthy pregnant women from January 2015 to May 2019. IR was calculated by HOMA2 (HOMA2-IR), QUICKI, and McAuley’s index. Fetal anthropometric measurements were assessed via ultrasound which was performed and interpreted by ultrasound experts.Results:In the simple regression analysis, McAuley’s index illustrated had statistically significant correlations to the highest number of risk factors of diabetes mellitus compared with HOMA2-IR and QUICKI indices. Moreover, McAuley’s index correlated statistically significantly to the highest number of fetal ultrasound measurements factors such as including biparietal diameter (BPD) (r = −0.271, P 
      Citation: Clinical Medicine Insights: Endocrinology and Diabetes
      PubDate: 2022-05-18T12:30:13Z
      DOI: 10.1177/11795514221098403
      Issue No: Vol. 15 (2022)
       
  • Evaluation of Patient Reported Satisfaction and Clinical Efficacy of
           Insulin Glargine 300 U/mL Versus 100 U/mL in Patients With Type 1
           Diabetes Using Flash Glucose Monitoring System

    • Authors: Ayman Abdullah Al Hayek, Asirvatham Alwin Robert, Abdulghani H Al Saeed, Mohamed Abdulaziz Al Dawish
      Abstract: Clinical Medicine Insights: Endocrinology and Diabetes, Volume 15, Issue , January-December 2022.
      Background and Aims:To analyze patient-reported satisfaction and clinical effectiveness of concentrated insulin glargine 300 U/mL (Gla-300) among patients with type 1 diabetes (T1D) using a flash glucose monitoring (FGM) system.Methods:This comparative study was conducted among 86 patients with T1D (aged 14-40 years), who were treated with Glargine 100 U/mL (Gla-100) and switched to Gla-300 at day 1 (baseline). The following data were collected from each patient: demographic information, clinical parameters, and glycemic control markers. All patients completed the Diabetes Treatment Satisfaction Questionnaire (Arabic version), first at baseline and then after 12 weeks. A comparison was done for all the data recorded at baseline (on Gla-100) and after 12 weeks (on Gla-300) and subjected to analysis.Results:Compared to patients treated with Gla-100, significant improvements were observed in the Gla-300 group, in terms of the ambulatory glucose profile (AGP) markers, such as percentage of time spent within the target range of the glucose levels (70-180 mg/dL) (P = .037), percentage which fell below the target (
      Citation: Clinical Medicine Insights: Endocrinology and Diabetes
      PubDate: 2022-05-18T12:19:57Z
      DOI: 10.1177/11795514221098415
      Issue No: Vol. 15 (2022)
       
  • Pre-test Cortisol Levels in Predicting Short Synacthen Test Outcome: A
           Retrospective Analysis

    • Authors: Ravikumar Ravindran, Joanne L Carter, Asit Kumar, Florin Capatana, Ishrat N Khan, Mohamed A Adlan, Lakdasa D Premawardhana
      Abstract: Clinical Medicine Insights: Endocrinology and Diabetes, Volume 15, Issue , January-December 2022.
      Objective:Short Synacthen tests (SSTs) are expensive, dependent on Synacthen availability, and need supervision. To reduce SST testing, we examined the utility of pre-test cortisol (Cort0) and related parameters in predicting outcome.Design and Measurements:We retrospectively examined the following in all SSTs; (i) Cort0 (ii) indications (iii) and time and place of testing. Receiver operated characteristic (ROC) curves were devised for Cort0 to obtain the best cut-off for outcome prediction in those who had SSTs between 8 and 10 am (Group 1) and at other times (Group 2).Results:Of 506 SSTs, 13 were unsuitable for analysis. 111/493 SSTs (22.5%) were abnormal. (1) ROC curves predicted – (a) SST failure with 100% specificity when Cort0 was ⩽124 nmol/L (Group 1), or ⩽47 (Group 2); (b) a normal SST with 100% sensitivity when Cort0 ⩾314 nmol/L (Group 1) and ⩾323 nmol/L (Group 2). (2) There was significant correlation between Cort0 and 30-minute cortisol (rs = 0.65-0.78, P  
      Citation: Clinical Medicine Insights: Endocrinology and Diabetes
      PubDate: 2022-05-06T01:56:57Z
      DOI: 10.1177/11795514221093316
      Issue No: Vol. 15 (2022)
       
  • The Relationship of Circulating Proprotein Convertase Subtilisin/Kexin
           Type 9 With TSH and Lipid Profile in Newly Diagnosed Patients With
           Subclinical and Overt Hypothyroidism

    • Authors: Noha Adly Sadik, Laila Ahmed Rashed, Shereen Sadik El-Sawy
      Abstract: Clinical Medicine Insights: Endocrinology and Diabetes, Volume 15, Issue , January-December 2022.
      Introduction:Overt and subclinical hypothyroidism are mostly associated with dyslipidemia, an essential cardiovascular risk factor. Recently, thyroid stimulating hormone (TSH) was identified to have a direct role on lipid metabolism via increased expression of hepatic proprotein convertase subtilisin/kexin type 9 (PCSK9). PCSK9 plays a crucial role in lipid metabolism via regulating LDL-C levels. Thus, we aimed to evaluate circulating PCSK9 levels and to assess its relationship with serum TSH and lipids in newly diagnosed patients had overt and subclinical hypothyroidism.Methods:In our study, we enrolled 60 newly diagnosed untreated patients with overt and subclinical hypothyroidism and 30 euthyroid subjects served as the control group. Serum TSH, FT4, FT3, lipid profile and circulating PCSK9 levels using ELISA kits were measured in all subjects. Our data were summarized using mean ± SD or median and interquartile range. Correlations between PCSK9 expression levels and different variables were done using Spearman correlation coefficient.Results:Circulating PCSK9 median levels were significantly increased in patients had overt and subclinical hypothyroidism (12.45 ng/ml, 7.50 ng/ml respectively) compared to the control group (3.30 ng/ml) (P 
      Citation: Clinical Medicine Insights: Endocrinology and Diabetes
      PubDate: 2022-04-21T10:34:54Z
      DOI: 10.1177/11795514221093317
      Issue No: Vol. 15 (2022)
       
  • Hyperinsulinemia Associated Depression

    • Authors: Haider Sarwar, Shafiya Imtiaz Rafiqi, Showkat Ahmad, Sruthi Jinna, Sawleha Arshi Khan, Tamanna Karim, Omar Qureshi, Zeeshan A Zahid, Jon D Elhai, Jason C Levine, Shazia J Naqvi, Juan C Jaume, Shahnawaz Imam
      Abstract: Clinical Medicine Insights: Endocrinology and Diabetes, Volume 15, Issue , January-December 2022.
      Hyperinsulinemia promotes fat accumulation, causing obesity. Being an inflammatory state, obesity can induce further inflammation and is a risk factor for HPA (hypothalamic pituitary axis) dysregulation through hypercortisolism-related hyperglycemia. In another hypothesis, the sympathetic nervous system (SNS) plays a significant role in the regulation of hormone secretion from the pancreas such as an increase in catecholamines and glucagon as well as a decrease in plasma insulin levels, a disruption on SNS activity increases insulin levels, and induces glycogenolysis in the liver and lipolysis in adipose tissue during hypoglycemia. Hyperglycemia-hyperinsulinemia exacerbates inflammation and increases the oxidative stress along with regulating the levels of norepinephrine in the brain sympathetic system. Increased inflammatory cytokines have also been shown to disrupt neurotransmitter metabolism and synaptic plasticity which play a role in the development of depression via inhibiting serotonin, dopamine, melatonin, and glutamate signaling. An increased level of plasma insulin over time in the absence of exercising causes accumulation of lipid droplets in hepatocytes and striated muscles thus preventing the movement of glucose transporters shown to result in an increase in insulin resistance due to obesity and further culminates into depression. Further hyperinsulinemia-hyperglycemia condition arising due to exogenous insulin supplementation for diabetes management may also lead to physiological hyperinsulinemia associated depression. Triple therapy with SSRI, bupropion, and cognitive behavioral therapy aids in improving glycemic control, lowering fasting blood glucose, decreasing the chances of relapse, as well as decreasing cortisol levels to improve cognition and the underlying depression. Restoring the gut microbiota has also been shown to restore insulin sensitivity and reduce anxiety and depression symptoms in patients.
      Citation: Clinical Medicine Insights: Endocrinology and Diabetes
      PubDate: 2022-04-21T10:33:30Z
      DOI: 10.1177/11795514221090244
      Issue No: Vol. 15 (2022)
       
  • Vitamin B12 (Cobalamin) Deficiency in Overt and Subclinical Primary
           Hypothyroidism

    • Authors: Mohamed Aon, Sherif Taha, Khaled Mahfouz, Mohamed M Ibrahim, Ahmed H Aoun
      Abstract: Clinical Medicine Insights: Endocrinology and Diabetes, Volume 15, Issue , January-December 2022.
      Background:B12 (cobalamin) deficiency has been reported in hypothyroid patients with variable prevalence rates thus routine screening of hypothyroid patients was recommended by some and discouraged by others. We aimed to assess the prevalence of B12 deficiency among hypothyroid patients and to evaluate for pernicious anemia and celiac disease as etiologies.Methods:A total 133 patients were included. Thyroid hormones and thyroid peroxidase (TPO) autoantibodies were measured. Serum B12 was measured and if deficient, intrinsic factor antibodies (IFAB) and tissue transglutaminase (tTG) antibodies were evaluated.Results:Our study included 45 patients with overt hypothyroidism (OH), 48 patients with subclinical hypothyroidism (SCH), and 40 patients as controls. Mean age was 34.3 years and 82% were females. TPO antibodies were positive in 73.5% of OH and 51.1% of SCH patients. B12 deficiency was detected in 33.3%, 47.9%, and 37.5% of OH, SCH, and controls, respectively with no significant difference (P = .334). Borderline-to-low B12 level was more prevalent in the OH and the SCH groups compared to controls (68.9%, 85.4%, and 57.5%, respectively; P = .014). Among B12-deficient hypothyroid patients, 7.5% had positive IFAB and 13.3% had positive tTG antibodies. We did not find a significant association of TPO positivity and B12 deficiency (OR, 0.69; 95% CI 0.3-1.57; P = .147).Conclusion:We did not find a higher prevalence of B12 deficiency among hypothyroid patients nor an association with TPO positivity. Borderline B12 levels were more prevalent among hypothyroid patients.
      Citation: Clinical Medicine Insights: Endocrinology and Diabetes
      PubDate: 2022-03-22T11:09:06Z
      DOI: 10.1177/11795514221086634
      Issue No: Vol. 15 (2022)
       
  • Thanks to Reviewer’s

    • Abstract: Clinical Medicine Insights: Endocrinology and Diabetes, Volume 15, Issue , January-December 2022.

      Citation: Clinical Medicine Insights: Endocrinology and Diabetes
      PubDate: 2022-03-12T08:49:21Z
      DOI: 10.1177/11795514221083443
      Issue No: Vol. 15 (2022)
       
  • Biomarkers and Prevalence of Cardiometabolic Syndrome Among People Living
           With HIV/AIDS, Addis Ababa, Ethiopia: A Hospital-Based Study

    • Authors: Minyahil Woldu, Omary Minzi, Workineh Shibeshi, Aster Shewaamare, Ephrem Engidawork
      Abstract: Clinical Medicine Insights: Endocrinology and Diabetes, Volume 15, Issue , January-December 2022.
      Background:While the fast extension of combination antiretroviral therapy (cART) has resulted in significant increases in life expectancy, disorders such as cardiometabolic syndrome (CMetS), which have received less attention, are becoming a major concern in HIV/AIDS patients (PLWHA).Objectives:The purpose of this research was to identify biomarkers and determine the prevalence of CMetS in PLWHA using the National Cholesterol Education Program (NCEP) and the International Diabetes Federation (IDF) tools.Methods:Between January 2019 and February 2021, a hospital-based study of HIV-infected patients (n = 288) was conducted. The data were analyzed using binary logistic regression. To control the effect of confounders, independent variables with a P-value of
      Citation: Clinical Medicine Insights: Endocrinology and Diabetes
      PubDate: 2022-02-24T09:17:24Z
      DOI: 10.1177/11795514221078029
      Issue No: Vol. 15 (2022)
       
  • Position of Sulfonylureas in the Current ERA: Review of National and
           International Guidelines

    • Authors: Viswanathan Mohan, Banshi Saboo, Jabbar Khader, Kirtikumar D Modi, Sushil Jindal, Subhash Kumar Wangnoo, Sugumaran Amarnath
      Abstract: Clinical Medicine Insights: Endocrinology and Diabetes, Volume 15, Issue , January-December 2022.
      Sulfonylureas (SUs) are one of the commonly prescribed oral anti-hyperglycemic agents (AHA) in low- and middle-income countries (LMICs), either in combination with metformin therapy or alone. However, concern about cardiovascular safety has limited the use of SUs in the management of type 2 diabetes mellitus (T2DM). Additionally, lack of uniformity in the national and international guidelines regarding the positioning of SUs in the management of diabetes has also been reported. The objective of this review was to assess the various national and international guidelines on diabetes management and understand the recommendations specific to SUs in various scenarios. A total of 33 national and international guidelines on the management of T2DM published in English were evaluated. These guidelines have considered the latest evidence and suggest the use of certain second-generation SUs as second-line therapy or in combination with other AHAs in select population and specific scenarios. Identification of the appropriate population, classification based on underlying risk, thorough assessment of the comorbid conditions, and a step-wise approach for the selection of appropriate SUs is essential for the effective management of T2DM. Additionally, cost-to–benefit ratio should be considered, particularly in LMICs, and SUs could continue to play an important role in such settings.
      Citation: Clinical Medicine Insights: Endocrinology and Diabetes
      PubDate: 2022-02-15T06:36:26Z
      DOI: 10.1177/11795514221074663
      Issue No: Vol. 15 (2022)
       
  • Potential Therapeutic Role for Apelin and Related Peptides in Diabetes: An
           Update

    • Authors: Ethan S Palmer, Nigel Irwin, Finbarr PM O’Harte
      Abstract: Clinical Medicine Insights: Endocrinology and Diabetes, Volume 15, Issue , January-December 2022.
      Type 2 diabetes mellitus (T2DM) is an epidemic with an ever-increasing global prevalence. Current treatment strategies, although plentiful and somewhat effective, often fail to achieve desired glycaemic goals in many people, leading ultimately to disease complications. The lack of sustained efficacy of clinically-approved drugs has led to a heightened interest in the development of novel alternative efficacious antidiabetic therapies. One potential option in this regard is the peptide apelin, an adipokine that acts as an endogenous ligand of the APJ receptor. Apelin exists in various molecular isoforms and was initially studied for its cardiovascular benefits, however recent research suggests that it also plays a key role in glycaemic control. As such, apelin peptides have been shown to improve insulin sensitivity, glucose tolerance and lower circulating blood glucose. Nevertheless, native apelin has a short biological half-life that limits its therapeutic potential. More recently, analogues of apelin, particularly apelin-13, have been developed that possess a significantly extended biological half-life. These analogues may represent a promising target for future development of therapies for metabolic disease including diabetes and obesity.
      Citation: Clinical Medicine Insights: Endocrinology and Diabetes
      PubDate: 2022-02-12T06:52:49Z
      DOI: 10.1177/11795514221074679
      Issue No: Vol. 15 (2022)
       
  • Hyperthyroidism and Liver Dysfunction: A Review of a Common Comorbidity

    • Authors: Ernest Yorke
      Abstract: Clinical Medicine Insights: Endocrinology and Diabetes, Volume 15, Issue , January-December 2022.
      Deranged liver enzymes due to hyperthyroidism rather than intrinsic liver pathology are not uncommon. The reported prevalence of liver biochemical abnormalities in patients with untreated thyrotoxicosis varies widely ranging from 15% to 76%. The suggested causes of liver dysfunction include direct hepatocyte injury, co-morbid heart failure, associated autoimmune conditions (especially in the setting of Graves’ Disease), preexisting liver disease and drugs including antithyroid medications. Although, some patients may have a pattern of mild liver injury, about 1% to 2% can have fulminant hepatitis. Liver enzymes can return to normalcy in as many as 77% to 83% of patients once the initiations of thionamides are started in a timely fashion, which can help forestall complications and prevent or minimize multi-organ dysfunction. Clinicians should maintain a high index of suspicion for underlying hyperthyroidism in patients presenting with unexplained liver dysfunction or unexplained jaundice.
      Citation: Clinical Medicine Insights: Endocrinology and Diabetes
      PubDate: 2022-02-08T05:21:07Z
      DOI: 10.1177/11795514221074672
      Issue No: Vol. 15 (2022)
       
 
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