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ENDOCRINOLOGY (149 journals)                     

Showing 1 - 134 of 134 Journals sorted alphabetically
AACE Clinical Case Reports     Hybrid Journal   (Followers: 5)
Acta Diabetologica     Hybrid Journal   (Followers: 17)
Adipositas - Ursachen, Folgeerkrankungen, Therapie     Hybrid Journal   (Followers: 1)
Advances in Chronic Kidney Disease     Hybrid Journal   (Followers: 15)
Advances in Diabetes and Metabolism     Open Access   (Followers: 22)
Advances in Endocrinology     Open Access   (Followers: 7)
AJP Endocrinology and Metabolism     Hybrid Journal   (Followers: 25)
American Journal of Kidney Diseases     Hybrid Journal   (Followers: 53)
Annales d'Endocrinologie     Hybrid Journal   (Followers: 2)
Applied Physiology, Nutrition and Metabolism     Hybrid Journal   (Followers: 37)
Best Practice & Research Clinical Endocrinology & Metabolism     Hybrid Journal   (Followers: 15)
BMC Endocrine Disorders     Open Access   (Followers: 8)
Case Reports in Endocrinology     Open Access   (Followers: 3)
Clinical Diabetes     Full-text available via subscription   (Followers: 40)
Clinical Diabetes and Endocrinology     Open Access   (Followers: 20)
Clinical Endocrinology     Hybrid Journal   (Followers: 42)
Clinical Medicine Insights : Endocrinology and Diabetes     Open Access   (Followers: 29)
Clinical Nutrition Insight     Full-text available via subscription   (Followers: 13)
Clinical Reviews in Bone and Mineral Metabolism     Hybrid Journal  
Comprehensive Psychoneuroendocrinology     Open Access  
Current Opinion in Endocrine and Metabolic Research     Hybrid Journal   (Followers: 1)
Current Opinion in Endocrinology, Diabetes and Obesity     Hybrid Journal   (Followers: 48)
Dermato-Endocrinology     Open Access   (Followers: 3)
Diabesity     Open Access   (Followers: 3)
Diabetes & Metabolic Syndrome: Clinical Research & Reviews     Hybrid Journal   (Followers: 27)
Diabetes & Metabolism     Hybrid Journal   (Followers: 72)
Diabetes, Obesity and Metabolism     Hybrid Journal   (Followers: 261)
Diabetes/Metabolism Research and Reviews     Hybrid Journal   (Followers: 63)
Diabetology & Metabolic Syndrome     Open Access   (Followers: 8)
Discover Oncology     Open Access   (Followers: 1)
Domestic Animal Endocrinology     Hybrid Journal   (Followers: 6)
Dubai Diabetes and Endocrinology Journal     Open Access  
Egyptian Journal of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Endocrine     Hybrid Journal   (Followers: 11)
Endocrine and Metabolic Science     Open Access   (Followers: 1)
Endocrine Connections     Open Access   (Followers: 4)
Endocrine Disruptors     Open Access  
Endocrine Journal     Open Access   (Followers: 13)
Endocrine Pathology     Hybrid Journal   (Followers: 7)
Endocrine Practice     Hybrid Journal   (Followers: 58)
Endocrine Regulations     Open Access  
Endocrine Research     Hybrid Journal   (Followers: 3)
Endocrine Reviews     Full-text available via subscription   (Followers: 44)
Endocrine, Metabolic & Immune Disorders - Drug Targets     Hybrid Journal   (Followers: 1)
Endocrine-Related Cancer     Full-text available via subscription   (Followers: 2)
Endocrinología, Diabetes y Nutrición (English Edition)     Hybrid Journal   (Followers: 2)
Endocrinology     Full-text available via subscription   (Followers: 50)
Endocrinology and Metabolism Clinics of North America     Full-text available via subscription   (Followers: 28)
Endocrinology, Diabetes & Metabolism     Open Access  
Endocrinology, Diabetes & Metabolism Case Reports     Open Access  
Endocrinology, Obesity and Metabolic Disorders     Full-text available via subscription   (Followers: 6)
Endokrynologia Polska     Open Access   (Followers: 2)
European Journal of Endocrinology     Full-text available via subscription   (Followers: 40)
European Thyroid Journal     Full-text available via subscription   (Followers: 3)
Experimental and Clinical Endocrinology & Diabetes     Hybrid Journal   (Followers: 24)
Experimental and Clinical Endocrinology & Diabetes Reports     Open Access   (Followers: 4)
Expert Opinion on Drug Metabolism & Toxicology     Hybrid Journal   (Followers: 15)
Expert Review of Endocrinology & Metabolism     Hybrid Journal   (Followers: 7)
Frontiers in Clinical Diabetes and Healthcare     Open Access  
Frontiers in Endocrinology     Open Access   (Followers: 5)
Frontiers in Neuroendocrine Science     Open Access  
Frontiers in Neuroendocrinology     Hybrid Journal   (Followers: 10)
General and Comparative Endocrinology     Hybrid Journal   (Followers: 5)
Growth Hormone & IGF Research     Hybrid Journal   (Followers: 14)
Gynakologische Endokrinologie     Hybrid Journal  
Gynecological Endocrinology     Hybrid Journal   (Followers: 5)
Hormone and Metabolic Research     Hybrid Journal   (Followers: 16)
Hormone Research in Paediatrics     Full-text available via subscription   (Followers: 16)
Hormones : International Journal of Endocrinology and Metabolism     Hybrid Journal  
Hormones and Behavior     Hybrid Journal   (Followers: 12)
Indian Journal of Endocrinology and Metabolism     Open Access   (Followers: 4)
International Journal of Clinical Endocrinology and Metabolism     Open Access   (Followers: 1)
International journal of endocrine oncology     Open Access  
International Journal of Endocrinology     Open Access   (Followers: 3)
International Journal of Endocrinology     Open Access   (Followers: 1)
International Journal of Endocrinology and Metabolism     Open Access   (Followers: 3)
International Journal of Obesity     Hybrid Journal   (Followers: 90)
International Journal of Osteoporosis and Metabolic Disorders     Open Access   (Followers: 1)
International Journal of Pediatric Endocrinology     Open Access   (Followers: 11)
JIMD Reports     Open Access  
Journal für Gynäkologische Endokrinologie/Österreich     Hybrid Journal  
Journal für Klinische Endokrinologie und Stoffwechsel : Austrian Journal of Clinical Endocrinology and Metabolism     Hybrid Journal  
Journal of Bone and Mineral Metabolism     Hybrid Journal   (Followers: 5)
Journal of Clinical and Translational Endocrinology     Open Access  
Journal of Clinical and Translational Endocrinology Case Reports     Open Access   (Followers: 2)
Journal of Clinical Endocrinology & Metabolism     Full-text available via subscription   (Followers: 139)
Journal of Developmental Origins of Health and Disease     Hybrid Journal   (Followers: 2)
Journal of Diabetes and Endocrinology     Open Access   (Followers: 7)
Journal of Diabetes and Endocrinology Assocation of Nepal     Open Access  
Journal of Diabetes and Metabolic Disorders     Open Access   (Followers: 8)
Journal of Diabetes Science and Technology     Hybrid Journal   (Followers: 13)
Journal of Diabetology     Open Access   (Followers: 1)
Journal of Endocrinological Investigation     Full-text available via subscription   (Followers: 7)
Journal of Endocrinology     Full-text available via subscription   (Followers: 13)
Journal of Endocrinology and Metabolism     Open Access   (Followers: 5)
Journal of Endocrinology and Reproduction     Hybrid Journal  
Journal of Endocrinology, Metabolism and Diabetes of South Africa     Open Access   (Followers: 8)
Journal of Inborn Errors of Metabolism and Screening     Open Access  
Journal of Molecular Endocrinology     Full-text available via subscription   (Followers: 5)
Journal of Neuroendocrinology     Hybrid Journal   (Followers: 8)
Journal of Pineal Research     Hybrid Journal   (Followers: 1)
Journal of Renal and Hepatic Disorders     Open Access  
Journal of Restorative Medicine     Open Access  
Journal of Social Health and Diabetes     Open Access   (Followers: 1)
Journal of the ASEAN Federation of Endocrine Societies     Open Access  
Kidney International     Hybrid Journal   (Followers: 52)
Kidney Research Journal     Open Access   (Followers: 6)
L'Endocrinologo     Hybrid Journal  
Metabolic Brain Disease     Hybrid Journal   (Followers: 1)
Metabolic Syndrome and Related Disorders     Hybrid Journal   (Followers: 5)
Metabolism     Hybrid Journal   (Followers: 11)
Molecular and Cellular Endocrinology     Hybrid Journal   (Followers: 8)
Molecular Metabolism     Open Access   (Followers: 9)
Nature Reviews Endocrinology     Full-text available via subscription   (Followers: 60)
Neuroendocrinology     Full-text available via subscription   (Followers: 8)
Nigerian Endocrine Practice     Full-text available via subscription  
Nutrition in Clinical Practice     Hybrid Journal   (Followers: 43)
Open Journal of Endocrine and Metabolic Diseases     Open Access   (Followers: 1)
Psychoneuroendocrinology     Hybrid Journal   (Followers: 15)
Reproductive Biology and Endocrinology     Open Access   (Followers: 3)
Reproductive Endocrinology     Open Access   (Followers: 1)
Reviews in Endocrine and Metabolic Disorders     Hybrid Journal   (Followers: 2)
Revista Argentina de Endocrinología y Metabolismo     Open Access  
Revista Cubana de Endocrinología     Open Access  
Revista Venezolana de Endocrinología y Metabolismo     Open Access  
Sri Lanka Journal of Diabetes Endocrinology and Metabolism     Open Access  
The Endocrinologist     Full-text available via subscription   (Followers: 6)
The Lancet Diabetes and Endocrinology     Full-text available via subscription   (Followers: 167)
Therapeutic Advances in Endocrinology and Metabolism     Open Access   (Followers: 5)
Thyroid     Hybrid Journal   (Followers: 11)
Thyroid Research     Open Access   (Followers: 3)
Thyroid Research and Practice     Open Access   (Followers: 3)
Trends in Endocrinology & Metabolism     Full-text available via subscription   (Followers: 19)
Vitamins & Hormones     Full-text available via subscription   (Followers: 1)


Similar Journals
Journal Cover
International Journal of Endocrinology
Journal Prestige (SJR): 1.012
Citation Impact (citeScore): 3
Number of Followers: 3  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1687-8337 - ISSN (Online) 1687-8345
Published by Hindawi Homepage  [339 journals]
  • Heat Shock Protein 70 Mediates the Protective Effect of Naringenin on
           High-Glucose-Induced Alterations of Endothelial Function

    • Abstract: Endothelial dysfunction plays a pivotal role in the development and progression of diabetic vascular complications. Naringenin (Nar) is a flavanone bioactive isolated from citrus fruits known to have in vitro and in vivo antidiabetic properties. However, whether Nar affects endothelial function remains unclear in diabetes or under high-glucose (HG) condition. Using an in vitro model of hyperglycemia in human umbilical vein endothelial cells (HUVECs), we found that Nar administration markedly attenuated HG-induced alterations of endothelial function, evidenced by the mitigation of oxidative stress and inflammation, the reduction of cell adhesion molecular expressions, and the improvement of insulin resistance. We also found that HG exposure significantly reduced the levels of intracellular heat shock protein 70 (iHSP70 or iHSPA1A) and the release of HSP70 from HUVECs. HSP70 depletion mimicked and clearly diminished the protective effects of Nar on HG-induced alterations of endothelial function. In addition, Nar treatment significantly enhanced iHSP70 protein levels through a transcription-dependent manner. These results demonstrated that Nar could protect HUVECs against HG-induced alterations of endothelial function through upregulating iHSP70 protein levels. These findings are also helpful in providing new therapeutic strategies that are promising in the clinical use of Nar for the treatment of diabetes and diabetic complications.
      PubDate: Mon, 01 Aug 2022 11:50:00 +000
  • Study of the Associations between Color Doppler Ultrasound Grading of
           Hyperthyroidism and Biochemical Data on Thyroid Function

    • Abstract: Objective. The main study objective was to investigate the correlation between the color Doppler ultrasound grading of hyperthyroidism and the biochemical data of thyroid function. Methods. Seventy-six patients were diagnosed with hyperthyroidism based on clinical and laboratory data at our hospital. The patients were examined using color Doppler ultrasound and laboratory investigations before starting 131I treatment. First, patients were divided into two groups based on the blood flow distribution determined by ultrasound. If the blood flow signal in the parenchyma was scattered and thinned, with dispersive points and discontinuous streaky distribution, the blood flow distribution area in the sample frame was less than or equal to 1/2 of the sample frame area and was judged to be level 1. If the parenchyma was filled with diffuse blood flow signals or if most areas had depicted rich blood flow distribution when the area of blood flow distribution in the sampling frame was greater than 1/2 of the sampling frame area, it was judged to be level 2. Then, the correlations between color Doppler ultrasound grading and biochemical data of thyroid function were analyzed. The indices included FT3, FT4, TSH, anti-TG, anti-TPO, and TRAb. Parameters of thyroid homeostasis, including thyroid’s secretory capacity (SPINA-GT), the total deiodinase activity (SPINA-GD), Jostel’s TSH index, and the thyrotroph thyroid hormone sensitivity index (TTSI), were calculated and compared. Results. Correlations were noted between color Doppler ultrasound grading and FT3, FT4, TRAb, SPINA-GT, TSHI, and TTSI. Moreover, FT3, FT4, TRAb, SPINA-GT, TSHI, and TTSI were higher in level 2 patients compared with level 1 patients. Conclusion. Correlations were noted between color Doppler ultrasound grading and biochemical data of thyroid function.
      PubDate: Sat, 30 Jul 2022 06:35:01 +000
  • ADSCs Combined with Melatonin Promote Peripheral Nerve Regeneration
           through Autophagy

    • Abstract: Background. In the early stage of nerve injury, damaged tissue is cleared by autophagy. ADSCs can promote nerve axon regeneration. However, the microenvironment of the injury was changed, and ADSCs are easily apoptotic after transplantation. Mel plays a role in the apoptosis, proliferation, and differentiation of ADSCs. Therefore, we investigated whether Mel combined with ADSCs promoted peripheral nerve regeneration by enhancing early autophagy of injured nerves. Materials and Methods. SD rats were randomly split into the control group, model group, Mel group, ADSCs group, ADSCs + Mel group, and 3-MA group. On day 7, autophagy was observed and gait was detected on days 7, 14, 21, and 28. On the 28th day, the sciatic nerve of rats’ renewal was detected. Results. After 1 w, compare with the model group, the number of autophagosomes and lysosomes and the expressions of protein of LC3-II/LC3-I and Beclin-1 in the ADSCs + Mel group were prominently increased, while the 3-MA group was significantly decreased. After 4 w, the function of the sciatic nerve in ADSCs + Mel was similar to that in the control group. Compared with the model group, the ADSCs + Mel group significantly increased myelin regeneration and the number of motor neurons and reduced gastrocnemius atrophy. Conclusions. It was confirmed that ADSCs combined with Mel could promote sciatic nerve regeneration in rats by changing the early autophagy activity of the injured sciatic nerve.
      PubDate: Wed, 20 Jul 2022 10:35:00 +000
  • The Prevalence and Characteristics of Exocrine Pancreatic Insufficiency in
           Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

    • Abstract: Background. Exocrine pancreatic insufficiency (EPI) is common in patients with type 2 diabetes. However, the prevalence of EPI varies significantly in different studies. Untreated EPI in these patients can adversely affect their nutrition and metabolism. The aim of this study is to estimate the pooled prevalence of EPI in patients with type 2 diabetes and to explore the potential risk factors. Methods. A systematic search was performed in PubMed, Web of Science, and Embase, which included studies meeting inclusion criteria from 1960 to 1 April 2021. Relevant articles were searched using the combination of Medical Subject Heading (MeSH) terms of “Type 2 diabetes” and “pancreatic exocrine insufficiency.” The Stata 16.0 software was used for data analyses. The random-effects model was used to estimate the pooled prevalence rates and 95% CI using “metaprop program.” Results. The pooled prevalence of EPI was 22% (95% CI: 15%–31%) in patients with type 2 diabetes and 8% (95% CI: 4%–14%) of them developed severe pancreatic insufficiency. In the subgroup analyses, the prevalence of EPI in type 2 diabetes was correlated with geographic location. The prevalence in Asian countries (35%, 95% CI: 22%–49%) is higher than in Europe (18%, 95% CI: 10%–29%) and Australia (9%, 95% CI: 4%–16%). Furthermore, patients with higher insulin requirements, who are more likely to be insulin-deficient, have a higher prevalence of EPI. The pooled prevalence was 27% (95% CI: 17%–37%) in type 2 diabetes with higher insulin requirement (1 group) and 15% (95% CI: 1%–40%) in patients with lower insulin requirement (2 group). In addition, the morbidity of severe EPI in the higher insulin requirement group (12%, 95% CI: 7%–19%) was sextuple as much as the lower insulin requirement group (2%, 95% CI: 0%–13%). EPI was more common in subjects younger than 60 compared with elderlies (25% vs. 19%). Conclusion. The prevalence of EPI in type 2 diabetes may be overestimated. Furthermore, the higher prevalence may be closely related to β-cell function. Endocrine disease therapy would potentially represent a novel therapeutic approach for patients with type 2 diabetes and EPI.
      PubDate: Tue, 19 Jul 2022 08:50:02 +000
  • Weight Gain and Body Composition Changes during the Transition of Thyroid
           Function in Patients with Graves’ Disease Undergoing Radioiodine

    • Abstract: Objective. This study aimed at investigating the dynamic changes in the body weight and body composition in a group of patients with Graves’ disease undergoing radioiodine therapy. Methods. Seventeen patients with Graves’ disease undergoing 131I treatment and forty-three euthyroid controls were recruited. Body weight, BMI, and body composition via bioelectrical impedance were measured for the participants at baseline, hypothyroid stage, and euthyroid stage. Results. Body weight increased significantly during the transition from hyperthyroidism to euthyroidism. However, there were no significant changes in body fat %, lean mass %, and bone mineral %. The body weight of 9 patients at the euthyroid stage exceeded their premorbid weight, while the remaining 8 patients’ weight did not exceed the premorbid weight. In the group with excessive weight gain, both body fat and lean mass increased significantly. However, in the group without excessive weight gain, only lean mass increased significantly. The patients with excessive weight gain had significantly higher body fat %, while lower lean mass % compared to patients without excessive weight gain at baseline and at the euthyroid stage. Moreover, body fat % of patients with excessive weight gain was significantly higher than that of controls, while lean mass % was significantly lower than that of controls. There was no difference of body fat % and lean mass % between patients without excessive weight gain and controls. Conclusion. 131I treatment caused significant weight gain in patients with Graves’ disease. An undesirable body composition at presentation may be a risk factor for excessive weight gain after hyperthyroidism treatment.
      PubDate: Mon, 18 Jul 2022 07:20:01 +000
  • Evaluation of Knowledge, Awareness, and Factors Associated with Diabetes:
           A Cross-Sectional Community-Based Study

    • Abstract: Background and objectives. Lack of knowledge and awareness about the disease is generally associated with wicked health outcomes. Diabetes is a chronic endocrine disease, affecting people of both genders and across all age groups, and is currently considered a major public health challenge globally. This study aims to assess the public’s knowledge, awareness, and associated demographic factors among general community. Methods. A cross-sectional study was carried out for over 4 months from May to August 2020 using a self-administered, anonymous online questionnaire. All adults of both genders were invited to participate in the study. Individuals who are able to read and understand the English language were included in the study. Data were descriptively analyzed using a statistical package for social science version 26 (SPSS). Results. A total of 427 subjects responded to the questionnaires. More than half of them were male 253 (59.3%), while 174 (40.7%) were female, approximately 49% had a university degree, and 196 (45.9%) were postgraduates. The mean age of the participants was 25.7 ± 6.2 (mean ± SD). Most of them were single 230 (53.9%). The majority of the respondents 367 (85.9%) had heard of hyperglycemia, while a comparable number of 366 (85.7%) were aware of it being a lifelong disease. About 305 (71.4%) of participants knew that genetic factors were associated with hyperglycemia, and more than half of 250 (58.5%) knew that diabetes causes foot problems. There was a significant association between the cause of diabetes with income and educational status ( 
      PubDate: Sat, 16 Jul 2022 06:20:01 +000
  • Genomic Analysis of Abnormal DNAM Methylation in Parathyroid Tumors

    • Abstract: Background. Parathyroid tumors are common endocrine neoplasias associated with primary hyperparathyroidism. Although numerous studies have studied the subject, the predictive value of gene biomarkers nevertheless remains low. Methods. In this study, we performed genomic analysis of abnormal DNA methylation in parathyroid tumors. After data preprocessing, differentially methylated genes were extracted from patients with parathyroid tumors by using t-tests. Results. After refinement of the basic differential methylation, 28241 unique CpGs (634 genes) were identified to be methylated. The methylated genes were primarily involved in 7 GO terms, and the top 3 terms were associated with cyst morphogenesis, ion transport, and GTPase signal. Following pathway enrichment analyses, a total of 10 significant pathways were enriched; notably, the top 3 pathways were cholinergic synapses, glutamatergic synapses, and oxytocin signaling pathways. Based on PPIN and ego-net analysis, 67 ego genes were found which could completely separate the diseased group from the normal group. The 10 most prominent genes included POLA1, FAM155 B, AMMECR1, THOC2, CCND1, CLDN11, IDS, TST, RBPJ, and GNA11. SVM analysis confirmed that this grouping approach was precise. Conclusions. This research provides useful data to further explore novel genes and pathways as therapeutic targets for parathyroid tumors.
      PubDate: Sat, 16 Jul 2022 06:05:00 +000
  • An Investigation on the Risk Factors of Thyroid Diseases in Community
           Population in Hainan

    • Abstract: Background. In recent years, the incidence of thyroid diseases has increased significantly, which has seriously affected people's work and life. The purpose of this study was to explore the epidemiological characteristics of thyroid diseases and autoantibodies. Method. According to the principle of overall sampling, resident residents ≥18 years and who will not move within 5 years are randomly selected. A total of 2136 eligible individuals were divided into case and control groups according to whether they have thyroid disease. Finally, the impact of potential risk factors on thyroid diseases was evaluated. Results. The overall prevalence of thyroid disease was 58.3%, and there was a significant difference in the prevalence of thyroid disease between women and men (p = 0.004). Except for the age group ≥70 years, with the increase in age, the prevalence gradually increased (p 
      PubDate: Sat, 09 Jul 2022 06:50:00 +000
  • Mechanisms Linking Vitamin D Deficiency to Impaired Metabolism: An

    • Abstract: Vitamin D deficiency is a common health problem worldwide. Despite its known skeletal effects, studies have begun to explore its extra-skeletal effects, that is, in preventing metabolic diseases such as obesity, hyperlipidemia, and diabetes mellitus. The mechanisms by which vitamin D deficiency led to these unfavorable metabolic consequences have been explored. Current evidence indicates that the deficiency of vitamin D could impair the pancreatic β-cell functions, thus compromising its insulin secretion. Besides, vitamin D deficiency could also exacerbate inflammation, oxidative stress, and apoptosis in the pancreas and many organs, which leads to insulin resistance. Together, these will contribute to impairment in glucose homeostasis. This review summarizes the reported metabolic effects of vitamin D, in order to identify its potential use to prevent and overcome metabolic diseases.
      PubDate: Wed, 06 Jul 2022 17:35:00 +000
  • Metabolic Effects of Recombinant Human Growth Hormone Replacement Therapy
           on Juvenile Patients after Craniopharyngioma Resection

    • Abstract: Objective: To investigate the effect of short-term recombinant human growth hormone (rhGH) replacement therapy on metabolic parameters in juvenile patients following craniopharyngioma (CP) resection. Methods. This retrospective study included 42 cases of juvenile patients that had undergone CP resection in the Department of Endocrinology at the Peking Union Medical College Hospital, from April 2013 to August 2020. According to whether they received growth hormone replacement therapy, the patients were divided into either the growth hormone replacement therapy (GHRT) group (30 cases) or the control group (12 cases). Changes in body mass index (BMI), BMI z-score, transaminase activity, fasting blood glucose (FBG) levels, blood lipid profile, and high-sensitivity C-reactive protein (hsCRP) levels were evaluated after one year of GHRT treatment. Results. The average age of the GHRT group was 13.00 (8.00–14.00) years old and these patients had undergone a CP operation an average of 2.00 (1.62–3.15) years earlier. Prior to receiving GHRT treatment, they received appropriate doses of adrenocortical hormone and thyroid hormone replacement therapy. After one year of GHRT treatment, the average BMI z-score decreased from 1.60 ± 1.76 to 1.13 ± 1.73 (). Alanine aminotransferase (ALT) activity decreased from 26.50 (17.00∼98.00) U/L to 18.00 (13.00∼26.48) U/L (), and similar changes were observed with regard to aspartate aminotransferase (AST) and glutamyl transferase (GGT) activity in the GHRT treatment group. The average total cholesterol (TC) decreased from 4.67 (4.10–6.14) mmol/L to 4.32 ± 0.85 mmol/L (), and low-density lipoprotein (LDL) levels decreased from 3.05 ± 0.95 mmol/L to 2.56 ± 0.65 mmol/L () in the GHRT treatment group. The average blood urea nitrogen level decreased from 4.53 ± 1.09 mmol/L to 3.92 ± 0.82 mmol/L () and the average serum creatinine (SCr) level decreased from 55.59 ± 12.54 µmol/L to 51.15 ± 10.51 µmol/L () in the GHRT treatment group. The average hsCRP level decreased from 3.23 (1.79∼4.34) mg/L to 0.92 (0.42∼1.21) mg/L in the GHRT treatment group. In the control group, the average ALT activity increased from 26.58 ± 8.75 U/L to 42.58 ± 24.59 U/L (), GGT activity increased from 19.0 (13.25–29.25) U/L to 25.00 (14.75–34.75) U/L (), and LDL levels increased from 2.27 ± 0.76 mmol/L to 3.43 ± 1.28 mmol/L ().Conclusion. GHRT treatment improves the metabolic parameters of juvenile patients that have undergone craniopharyngioma resection by reducing BMI z-scores, low-density lipoprotein, and hsCRP levels and improving liver function.
      PubDate: Wed, 06 Jul 2022 08:05:01 +000
  • Gender and Age-Specific Differences in the Association of Thyroid Function
           and Hyperuricemia in Chinese: A Cross-Sectional Study

    • Abstract: Objective. We aimed to explore gender and age-specific influences on the association between thyroid function and hyperuricemia (HUA) in a large Chinese population. Methods. A total of 19,013 individuals (10,563 males and 8,450 females) were recruited. The association between HUA and thyroid function was analyzed by multivariate logistic regression, and the analyses were stratified by gender and age. Thyroid function subgroups were determined in 2 methods including thyroid status and thyroid-stimulating hormone (TSH) quartiles. Results. Overall prevalence of serum uric acid (SUA) and HUA was significantly higher in males, while TSH value and thyroid dysfunction were higher in females. Increasing trends of the TSH level in both genders as well as HUA prevalence in females were found positively along with aging. However, males showed a reduced trend in HUA risk negatively with aging. Our population showed that the risk of developing HUA in hyperthyroidism, normal euthyroidism, mild hypothyroidism, and overt hypothyroidism subgroups had adjusted ORs of 0.634, 1.229, 1.370, and 1.408, respectively, in males. Subjects in females showed a similar increased risk of HUA with ORs of 0.770, 1.198, 1.256, and 1.458, respectively. Similar tendency was observed in TSH quartiles; the above two models showed significantly higher risk of HUA in the high TSH group of males, but not of females. Aging was a significant risk factor for HUA, particularly in older females after adjusting for TSH. Conclusion. The risk of HUA was positively associated with an elevation in TSH levels in both genders irrespective of age, indicating the protective effects of low TSH on HUA. Males with high TSH value were more vulnerable to suffer significant risk of HUA.
      PubDate: Tue, 05 Jul 2022 09:05:01 +000
  • Corrigendum to “Prognostic Factors for COVID-19 Hospitalized Patients
           with Preexisting Type 2 Diabetes”

    • PubDate: Mon, 04 Jul 2022 10:50:02 +000
  • Comparative Potential of Zinc Sulfate, L-Carnitine, Lycopene, and Coenzyme
           Q10 on Cadmium-Induced Male Infertility

    • Abstract: The human exposure to toxic chemicals and heavy metals is one of the main predisposing factors contributing to male infertility. Acute exposure to cadmium chloride results in testicular damage and infertility. The purpose of the present study was to investigate and compare the curative effect of coenzyme Q10 (CoQ10), lycopene, L-carnitine (LC), and zinc sulfate against the cadmium-induced infertility in male Wistar rats. Cadmium chloride (0.4 mg/kg/day) was orally administered to rats for three consecutive days. Then, oral administration of different treatments (i.e., LC 100 mg/kg, CoQ10 20 mg/kg, lycopene 4 mg/kg, zinc sulfate 6 mg/kg, and a combination LC-CoQ10 at 500/50 mg/kg) was carried out for 30 days. The impact of different treatments on semen parameters, such as sperm count and motility, testicular antioxidants, and serum testosterone, was determined. Furthermore, the morphology of epididymis sperms and histopathology of rat testes were also assessed. Cadmium exposure decreased the sperm count, progressive sperm motility, testosterone, superoxide dismutase (SOD), and catalase and reduced glutathione (GSH). It also caused banana sperm tail, bent sperm head, vacuolization of seminiferous tubules, and oligospermia in rat testes. All treatments with nutraceuticals improved sperm count, sperm morphology, serum testosterone, vacuolization of seminiferous tubules, and oligospermia in diseased rats. Treatment with lycopene, LC, and LC-CoQ10 improved progressive sperm motility and other parameters and increased SOD, GSH, and CAT in the rat testes. CoQ10 also increased SOD activity in rat testes’ tissue homogenates. It is concluded from the current study that all nutraceuticals partially improved reproductive toxicity of cadmium. The administration of lycopene and a high-dose combination of LC-CoQ10 were more efficacious in treating cadmium-induced infertility than other treatments. Treatment of cadmium-exposed rats with lycopene, LC, CoQ10, and LC-CoQ10 improved sperm count and motility through reduction of testicular oxidative stress and improving serum testosterone.
      PubDate: Thu, 30 Jun 2022 06:05:00 +000
  • Triglyceride-Glucose Index for the Diagnosis of Metabolic Syndrome: A
           Cross-Sectional Study of 298,652 Individuals Receiving a Health Check-Up
           in China

    • Abstract: Objective. We herein aim to explore the relationship between the triglyceride-glucose (TyG) index and metabolic syndrome (MS). Methods. We enrolled 298,652 individuals with an average age of 47.08 ± 12.94 years and who underwent health check-ups at the First Affiliated Hospital of Wuhu Wannan Medical College in this cross-sectional study from 2014 to 2016. We enlisted 125,025 women (41.86%) and 173,627 men (58.14%). The survey information included a questionnaire survey, a physical examination, and a laboratory examination. Results. The prevalence of MS increased gradually in the TyG-index subgroups (Q1, TyG
      PubDate: Wed, 29 Jun 2022 07:50:01 +000
  • Risk Factors for Contralateral Occult Papillary Thyroid Carcinoma in
           Patients with Clinical Unilateral Papillary Thyroid Carcinoma: A
           Case-Control Study

    • Abstract: Introduction. Papillary thyroid cancer (PTC) is one of the most prevalent endocrine malignancies that has increased in recent decades around the world. Although the indicator for navigating the surgical extent in PTC patients is still in debate, a key issue is how to predict that there are undetected preoperative tumors in the contralateral thyroid lobe. This study aims to find risk factors for contralateral occult papillary thyroid cancer (COPTC) to facilitate more accurate surgical decisions made for patients with PTC. Materials and Methods. In our study, we included 229 patients who underwent total thyroidectomy plus central and ipsilateral lateral lymph nodes dissection from January 1, 2019, to September 1, 2021. Univariate and multivariate logistic regression analyses were conducted to assess the association between COPTC and clinical-pathological characteristics, as well as the relation between the diameter of the occult lesions and predictors. The forest plot was plotted to visualize the prediction factors from the output of the multivariate regression analysis. A ROC curve was used to evaluate the combining potency of all the risk factors. Results. Of the 229 patients included in our study, 46 with COPTC were assigned to the case group, representing 20.1% in this study. Multifocality in one lobe (OR = 2.21, ), intact capsule (OR = 2.54, ), central lymph node metastasis (OR = 3.00, ), and Hashimoto’s thyroiditis (OR = 2.08, P = 0.04) are more prone to present contralateral occult papillary thyroid carcinoma. The ROC curve of the aggregate potency of the risk factors presents AUC = 0.701 (), and the best cutoff value was 2.02, with a sensitivity of 78.3% and specificity of 55.2%. Furthermore, there was no statistical correlation between the diameter of the occult tumor and the four obtained variables. Conclusion. Patients with multifocality in one lobe, intact capsule, central lymph node metastasis, and HT may harbor contralateral papillary thyroid carcinoma. It is essential to be prudent to make a surgical or follow-up decision on these patients. In addition, more clinical rather than postoperative pathological indicators need to be revealed in the future.
      PubDate: Tue, 28 Jun 2022 07:05:01 +000
  • Retrospective Study of Recurrence and Associated Factors of Type 2
           Diabetes Treated at Adama General Hospital, Oromia, Ethiopia: A Comparison
           of Cox-PH and Shared Lognormal Frailty Models

    • Abstract: Background. Recovery from type 2 diabetes is frequently recurrent, as a single patient may recover from more than one over time. The goal of this study was to know the recurrent event (time to recovery) and associated factors of type 2 diabetes in Adama General Hospital, Ethiopia, by comparing shared lognormal frailty and Cox-PH models. Methods. A retrospective analysis of 302 type 2 diabetic patients (01, 2011–01, and 2016) was considered. Descriptive statistics were used to summarize the study variables. The standard Cox-proportional hazards model and a shared lognormal frailty model have been compared. The latter model with a 95% significance level was fitted, variables with were considered significant, and the adjusted hazard ratio has been used to measure the strength of the risk. Results. About 56.6% of the patients recovered. The average recovery time was 33.53 (standard deviation, 20.404 ) weeks. Gender (adjusted HR = 1.168, 95% CI = (0.93, 1.46), ), family history (adjusted HR = 0.765, 95% CI = (0.59, 0.99), ), cholesterol level (adjusted HR = 0.738, 95% CI = (0.57, 0.96), ), alcohol use (adjusted HR = 0.698, 95% CI = (0.53, 0.92), ), and smoking cigarette (adjusted HR = 0.674, 95% CI = (0.51, 0.89), ) were statistically significant. The estimated frailty term’s variance was 0.426 (). Also, the author presents a comparison study for the same data by using a model selection criterion and suggests a better model (shared lognormal frailty model). Conclusion. Finally, the median recovery time was 30 weeks. Female patients had a better chance of recovery than male patients. A shared lognormal frailty model outperformed the Cox-PH model in fitting the data and controlling event interdependence. There was risk heterogeneity among patients. Positive family history, high cholesterol level, alcohol use, and smoking have an inverse relationship with the overall likelihood of the patients’ recovery time. Therefore, future improvement measures against type 2 DM recovery should take all events (for example, the first, second, and third recovery in this study) and these identified factors into account.
      PubDate: Mon, 27 Jun 2022 08:05:00 +000
  • Peripheral Blood Inflammatory Markers Can Predict Benign and Malignant
           Thyroid Nodules

    • Abstract: Objective. Inflammation is related to the occurrence and development of various cancers. This study was designed to explore the role of peripheral blood platelet count, neutrophil-lymphocyte ratio (NLR), platelet count-lymphocyte count ratio (PLR), systemic inflammation index (SII), and other inflammatory markers in predicting benign and malignant Thyroid Imaging Reporting and Data System (TI-RADS) grade 3 thyroid nodules. Methods. In this retrospective study, 514 patients with TI-RADS grade 3 thyroid nodules were enrolled. According to the pathological results, the patients were divided into the benign and malignant nodule groups. We compared the clinical characteristics between the two groups and analysed the influencing factors for malignant thyroid nodules by univariate and stepwise multivariate logistic regression analyses and then analysed the cutoff value of each influencing factor according to the receiver operating characteristic curve. Results. The leukocyte count, neutrophil count, platelet count, NLR, PLR, and SII of the malignant nodule group were significantly higher than those of the benign nodule group (), the age and the diameter of nodule of the malignant nodule group were significantly smaller than those of the benign nodule group (). After excluding the influence of confounding factors, SII (odds ratio (OR) = 1.006; 95% confidence interval (CI) = 1.003–1.008; ), PLR (odds ratio (OR) = 0.981; 95% confidence interval (CI) = 0.981–0.992; ), leukocyte count (odds ratio (OR) = 0.654; 95% confidence interval (CI) = 0.466–0.892; ), and age (OR = 0.969; 95% CI = 0.954–0.985; ) were independent risk factors for malignant thyroid nodules, and the cutoff value of SII and PLR in predicting benign and malignant thyroid nodules were 545.63 × 109/L and 138.63. Conclusion. This study showed that peripheral blood SII, PLR, leukocyte count and age were independent risk factors for malignant thyroid nodules, and the combination of these can better predict benign and malignant thyroid nodules, which can further guide the diagnosis and treatment of TI-RADS grade 3 thyroid nodules.
      PubDate: Sun, 26 Jun 2022 10:50:03 +000
  • Fine-Needle Pricking Test of the Parathyroid Gland during Thyroid Surgery
           in Predicting Parathyroid Function

    • Abstract: Background. Permanent hypoparathyroidism is a serious complication following total thyroidectomy plus central neck dissection (CND). How to evaluate the vascularization of the parathyroid gland in real time is a major concern of thyroid surgeons. This study aimed to evaluate the fine-needle pricking (FNP) test in predicting parathyroid gland function. Methods. The FNP test was performed in patients undergoing total thyroidectomy plus CND between January 1, 2014, and December 31, 2019, to visualize the vascularization of the parathyroid glands. Patients were classified according to the number of parathyroid glands preserved in situ with excellent vascularity (PGPIEV) demonstrated by FNP: group 0 (without PGPIEV), group 1 (with one PGPIEV), group 2 (with two PGPIEV), group 3 (with three PGPIEV), and group 4 (with four PGPIEV). Results. A total of 608 patients with four parathyroid glands underwent FNP testing during thyroidectomy. At least one PGPIEV was demonstrated by FNP testing in 581 patients who had intact parathyroid hormone (iPTH) levels in the normal range after the operation. The prevalence of hypocalcemia decreased from 77.8% in group 0 to 9.8% in group 4 (), and the incidence of hypoparathyroidism decreased from 44.4% in group 0 to 0% in groups 1–4 (). iPTH concentrations on postoperative day 1 were positively correlated with PGPIEV groups (increased from 14.58 ng/l in group 0 to 45.22 ng/l in group 4, ).Conclusions. The FNP test is a safe and reliable method to predict parathyroid function. One PGPIEV demonstrated by the FNP test rules out the possibility of patients developing hypoparathyroidism.
      PubDate: Sat, 25 Jun 2022 06:50:02 +000
  • Seasonal Variation of Testosterone Levels in a Large Cohort of Men

    • Abstract: Context. Various data suggest seasonal variation in testosterone levels. However, previous studies are limited by their size or by variability in baseline characteristics. Objectives. The aim of the study was to evaluate in a large cohort of males with a wide range of age, metabolic status, and coexistent morbidities whether month of blood test performance was associated with total and bioavailable testosterone levels independent of age, body mass index (BMI), existing cardiovascular disease (CVD), and CVD risk factors. Methods. Cross-sectional study includes data from computerized medical records of 27,328 men aged 20–70, treated by the largest healthcare organization in Israel, who had undergone testosterone measurement. In 7,940 subjects with available sex-hormone-binding globulin levels, bioavailable testosterone was calculated. Results. Total and bioavailable testosterone levels gradually decreased with age and BMI () and were significantly lower in men with diabetes, hypertension, hyperlipidemia, and known CVD, but were higher in current smokers compared with nonsmokers (). Hormone levels were highest in August-October declined after and lowest in March. Overall, both total and bioavailable testosterone levels were significantly lower in March compared to August-October (). In a linear regression analysis, age, BMI, current smoking, and month of testing were independently associated with total () and bioavailable testosterone levels (), and diabetes was associated with total testosterone ().Conclusion. In a large cohort of men with a wide range of age, BMI, and comorbidities, month of testing was independently associated with total and bioavailable testosterone levels. These data provide strong evidence that seasonal variation has to be considered in clinical practice.
      PubDate: Wed, 22 Jun 2022 10:35:01 +000
  • Serum Cortisol, 25 (OH)D, and Cardiovascular Risk Factors in Patients with
           Type 2 Diabetes Mellitus

    • Abstract: Background and Aims. The effects of cortisol on cardiovascular diseases (CVD) and CVD risk are unknown, especially in patients with type 2 diabetes mellitus (T2DM). Furthermore, it is unclear whether 25 (OH)D can alter the associations of cortisol with CVD and CVD risk factors. Thus, the present study was to investigate the associations of serum cortisol with CVD and CVD risk factors and whether 25 (OH)D altered these associations among patients with T2DM. Materials and methods. A total of 762 patients diagnosed with T2DM were recruited. The levels of serum cortisol and 25 (OH)D were measured with a liquid chromatography-tandem mass spectrometry. Logistic regression and linear regression were used to assess the association of cortisol with CVD and multiple cardiovascular risk factors. Modification analyses were performed to identify whether 25 (OH)D altered the above associations. Results. A 1 SD increase in cortisol was associated with a higher prevalence of stroke (odds ratio (OR): 1.25, 95% confidence interval (CI): 1.05, 1.50). Elevated cortisol was associated with related cardiovascular risk factors, including deceased ß cell function, high-density lipoprotein-cholesterol (HDL-C), and fasting insulin, as well as increased triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), fasting plasma glucose (FPG), and glycated hemoglobin (HbA1c). In addition, modification analyses suggested that the associations of cortisol with ß cell function, fasting insulin, FPG, and HbA1c were modified by 25 (OH)D. Conclusions. Serum cortisol was associated with the prevalence of stroke and cardiovascular risk factors, and the associations of cortisol with cardiovascular risk factors were moderated by 25 (OH)D, suggesting that T2DM patients with exposure to lower 25 (OH)D levels and higher cortisol levels were more susceptible to have higher cardiovascular risk factors.
      PubDate: Sat, 18 Jun 2022 07:05:00 +000
  • Development of a Novel Algorithm to Identify People with High Likelihood
           of Adult Growth Hormone Deficiency in a US Healthcare Claims Database

    • Abstract: Objective. Adult growth hormone deficiency (AGHD) is an underdiagnosed disease associated with increased morbidity and mortality. Identifying people who may benefit from growth hormone (GH) therapy can be challenging, as many AGHD symptoms resemble those of aging. We developed an algorithm to potentially help providers stratify people by their likelihood of having AGHD. Design. The algorithm was developed with, and applied to, data in the anonymized Truven Health MarketScan® claims database. Patients. A total of 135 million adults in the US aged ≥18 years with ≥6 months of data in the Truven database. Measurements. Proportion of people with high, moderate, or low likelihood of having AGHD, and differences in demographic and clinical characteristics among these groups. Results. Overall, 0.5%, 6.0%, and 93.6% of people were categorized into groups with high, moderate, or low likelihood of having AGHD, respectively. The proportions of females were 59.3%, 71.6%, and 50.4%, respectively. People in the high- and moderate-likelihood groups tended to be older than those in the low-likelihood group, with 58.3%, 49.0%, and 37.6% aged >50 years, respectively. Only 2.2% of people in the high-likelihood group received GH therapy as adults. The high-likelihood group had a higher incidence of comorbidities than the low-likelihood group, notably malignant neoplastic disease (standardized difference −0.42), malignant breast tumor (−0.27), hyperlipidemia (−0.26), hypertensive disorder (−0.25), osteoarthritis (−0.23), and heart disease (−0.22). Conclusions. This algorithm may represent a cost-effective approach to improve AGHD detection rates by identifying appropriate patients for further diagnostic testing and potential GH replacement treatment.
      PubDate: Sat, 18 Jun 2022 07:05:00 +000
  • The Prognostic Implication of the BRAF V600E Mutation in Papillary Thyroid
           Cancer in a Chinese Population

    • Abstract: Background. The BRAF V600E mutation is an important genetic event in papillary thyroid cancer (PTC). This study aimed to provide additional information regarding the association of the BRAF V600E mutation with PTC prognosis. Methods. A retrospective single-center study based on a Chinese population was performed to analyze the association of the BRAF V600E mutation with several clinicopathological features. Kaplan–Meier survival curves and Cox proportional hazards regression analysis were applied to implement the survival analysis. Results. The BRAF V600E mutation was present in 1102 (87.7%) of the 1257 patients and was significantly associated with older age, conventional subtype, multifocality, advanced TNM stage, and a reduced prevalence of Hashimoto’s thyroiditis. The Kaplan–Meier survival curves demonstrated that the difference between the BRAF V600E-positive and BRAF V600E-negative groups was significant with a log-rank P-value of 0.048. The Cox proportional hazards regression analysis adjusted HR was 3.731 (95% CI, 1.457 to 9.554). We further demonstrated that larger tumor size (>1 cm), extrathyroidal extension (ETE), and lateral lymph node metastasis (LNM) were associated with a higher probability of PTC recurrence in patients harboring the BRAF V600E mutation. Conclusions. The BRAF V600E mutation remains an independent risk factor for PTC recurrence and may be useful for clinical decisions when it combines with some pathological factors.
      PubDate: Thu, 16 Jun 2022 10:05:01 +000
  • TET3 Mediates 5hmC Level and Promotes Tumorigenesis by Activating AMPK
           Pathway in Papillary Thyroid Cancer

    • Abstract: Thyroid cancer is the most common endocrine malignant tumor. The accurate risk stratification and prognosis assessment is particularly important for patients with thyroid cancer, which can reduce the tumor recurrence rate, morbidity, and mortality effectively. DNA methylation is one of the most widely studied epigenetic modifications. Many studies have shown that 5hmC-mediated demethylation played an important role in tumors. The hydroxylation of 5mC is catalyzed by ten-eleven translocation dioxygenase (TET). In this study, we first found that the abnormal expression of 5hmC was closely related to microcarcinoma, multifocal, extraglandular invasion and lymph node metastasis of thyroid carcinoma. Then, we identified TET3 was differentially expressed in thyroid cancers and normal tissues from the TET family. TET3 can promote the proliferation, migration, and invasion of thyroid cancer. TET3-mediated 5hmC can regulate the transcription of AMPK pathway-related genes to activate the AMPK pathway and autophagy and therefore promote PTC proliferation. These findings provide a preclinical rationale for the design of novel therapeutic strategies for this target to improve the clinical outcome of patients with PTC.
      PubDate: Wed, 15 Jun 2022 10:05:01 +000
  • miR-124-3p Combined with ANGPTL2 Has High Diagnostic Values for Obese and
           Nonobese Polycystic Ovary Syndrome

    • Abstract: Polycystic ovary syndrome (PCOS) is a hormonal disorder that affects 5–20% of women of reproductive age. Interestingly, serum miR-124-3p and ANGPTL2 are differentially expressed in PCOS patients. Accordingly, this study set out to explore the clinical roles of serum miR-124-3p/ANGPTL2 in PCOS. Firstly, miR-124-3p/ANGPTL2 expression patterns were detected in the serum of 102 PCOS patients and 100 healthy subjects. miR-124-3p or/and ANGPTL2 diagnostic efficacy on PCOS was further analyzed, in addition to the measurement of lipid metabolism, glucose metabolism, sex hormone indexes, and inflammation levels. Correlations between serum miR-124-3p/ANGPTL2 expressions and age, BMI, Ferriman–Gallwey score, lipid metabolism, glucose metabolism, sex hormone indexes, TNF-α, and IL-6 in PCOS patients were determined. The expression correlation and binding relationship of ANGPTL2 and miR-124-3p were identified. In addition, miR-124-3p was downregulated and ANGPTL2 was upregulated in the serum of obese and nonobese PCOS patients. miR-124-3p expression was found to be negatively correlated with Ferriman–Gallwey score and serum total testosterone (T), and negatively related to prolactin (PRL). ANGPTL2 expression was positively correlated with FNS and inversely linked with PRL. TNF-α and IL-6 were negatively correlated with miR-124-3p, but positively correlated with ANGPTL2. Furthermore, there was a negative correlation and a targeting relationship between ANGPTL2 and miR-124-3p expression in the serum of obese and nonobese PCOS patients. Collectively, our findings indicated that miR-124-3p might target ANGPTL2 expression in obese and nonobese PCOS patients, and further underscored the diagnostic value of their combination.
      PubDate: Tue, 14 Jun 2022 10:35:01 +000
  • Exosomal Circular RNA hsa_circ_0046060 of Umbilical Cord Mesenchymal
           Stromal Cell Ameliorates Glucose Metabolism and Insulin Resistance in
           Gestational Diabetes Mellitus via the miR-338-3p/G6PC2 Axis

    • Abstract: Background. Impaired glucose metabolism and insulin sensitivity have been linked to the pathogenesis of gestational diabetes mellitus (GDM). Exosomes secreted by the umbilical cord mesenchymal stromal cells (UMSCs) and circular RNAs (circRNAs) derived from exosomes have been shown to be associated with the progression of GDM-related complications. Methods. UMSCs were isolated from umbilical cords and identified through flow cytometry. Exosomes were isolated from UMSCs and were then characterized. The expression levels of RNA of hsa_circ_0046060, mmu_circ_0002819, and miR-338-3p were determined by quantitative real-time polymerase chain reaction (RT-qPCR). The intracellular glucose intake and glycogen content were measured using a High Sensitivity Glucose Assay Kit and Glycogen Assay Kit, respectively. Bioinformatics analysis and luciferase reporter assay were used to validate interactions among hsa_circ_0046060, miR-338-3p, and G6PC2. The expression of insulin receptor substrate-1 (IRS-1) and its phosphorylated form, (p-IRS-1), as well as G6PC2, was determined through western blotting. Results. UMSCs and exosomes were successfully isolated and identified. The upregulation of hsa_circ_0046060 decreased the intracellular glucose content in L-02 cells (43.45 vs. 16.87 pM/mg, ), whereas shRNA-mediated downregulation reversed this effect (16.87 vs. 33.16 pM/mg, ). Mmu_circ_0002819 in mice aggravated dysregulated glucose metabolism (49.88 vs. 21.69 pM/mg, ) and insulin sensitivity (0.20 vs. 0.11 mg/mL, ) in GDM mice, which was abrogated by the knockdown of mmu_circ_0002819. The results of luciferase reporter assay revealed that miR-338-3p and G6PC2 were the potential targets of has_circ_0046060. Western blotting results showed that the reduced activation of IRS-1 induced by GDM (1.25 vs. 0.54, ) could be rescued by the administration of si-circ-G-UMSC-EXOs (0.54 vs. 1.17, ).Conclusion. Taken together, the inhibition of hsa_circ_0046060 expression in exosomes from GDM-derived UMSCs can alleviate GDM by reversing abnormal glucose metabolism and insulin resistance in vivo and in vitro.
      PubDate: Sat, 11 Jun 2022 07:20:01 +000
  • miR-149-3p Is a Potential Prognosis Biomarker and Correlated with Immune
           Infiltrates in Uterine Corpus Endometrial Carcinoma

    • Abstract: Background. Endocrine disruption is an important factor in the development of endometrial cancer. Expression of miR-149-3p is observed in some cancer types, while its role in uterine corpus endometrial carcinoma (UCEC) is unclear. Methods. The clinical and genomic data and prognostic information on UCEC were obtained for patients from the TCGA database. The Kruskal–Wallis test, Wilcoxon signed-rank test, and logistic regression were used to analyze the relationship between clinical characteristics and miR-149-3p expression. Kaplan–Meier survival curve analysis was used to study the influence of miR-149-3p expression and miR-149-3p target genes on the prognosis of UCEC patients. The TargetScan, PicTar, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were used to determine the involvement of miR-149-3p target genes in function. Immune infiltration analysis was used to analyze the functional involvement of miR-149-3p. QRT-PCR was used to validate the expression of miR-149-3p in UCEC cell lines. Results. High expression of miR-149-3p in UCEC was significantly associated with age (), histological type (), histological grade (), tumor invasion (), and radiation therapy (). High miR-149-3p expression predicted poorer overall survival (OS) (HR: 2.56; 95% CI: 1.64–4.00; ), progression-free interval (PFI) (HR: 1.85; 95% CI: 1.29–2.65; ), and disease-specific survival (DSS) (HR: 2.33; 95% CI: 1.37–3.99; ). Low expressions of miR-149-3p target genes, including ADCYAP1R1, CGNL1, CHST3, CYGB, DNAH9, ESR1, HHIP, HIC1, HOXD11, IGF1, INMT, LSP1, MTMR10, NFIC, PLCE1, RARA, SNTN, SPRYD3, and ZBTB7A, were associated with poor OS in UCEC. MiR-149-3p may be involved in the occurrence and development of UCEC via pathways including PI3K-Akt signaling pathway, Ras signaling pathway, AGE-RAGE signaling pathway in diabetic complications, focal adhesion, and MAPK signaling pathway. miR-149-3p may inhibit the function of CD8 T cells, cytotoxic cells, eosinophils, iDC, mast cells, neutrophils, NK CD56bright cells, NK CD56dim cells, pDC, T cells, T helper cells, TFH, Th17 cells, and Treg. miR-149-3p was significantly upregulated in UCEC cell lines compared with endometriotic stromal cells. Conclusion. High expression of miR-149-3p was significantly associated with poor survival in UCEC patients. It may be a promising biomarker of prognosis and response to immunotherapy for UCEC patients.
      PubDate: Wed, 08 Jun 2022 18:50:04 +000
  • The Determinants of Adolescent Glycolipid Metabolism Disorder: A Cohort

    • Abstract: Background. The increased prevalence of glycolipid metabolism disorders (GLMD) in childhood and adolescents has a well-established association with adult type 2 diabetes and cardiovascular diseases; therefore, determinants of GLMD need to be evaluated during this period. Objectives. To explore the prevalence of and risk factors for GLMD from the prenatal period through childhood and adolescence. Methods. A bidirectional cohort study which was established in 2014 and followed between March 1 and July 20, 2019, was used to illustrate the impact factors for GLMD. Stratified cluster sampling in urban-rural areas was used to include subjects from four communities in Chongqing. 2808 healthy children aged between 6 and 9 years in 2014 entered the cohort in 2014 and followed in 2019 with a follow-up rate of 70%. 2,136 samples (aged 11.68 ± 0.60 years) were included. Results. The prevalence rates of insulin resistance (IR), prediabetes/diabetes, and dyslipidemia were 21.02%, 7.19%, and 21.61%, respectively. Subjects with an urban residence, no pubertal development, dyslipidemia in 2014, higher family income, and higher parental education had significantly elevated fasting insulin (FI) or homeostasis model assessment of insulin resistance (HOMA-IR) levels; subjects with female sex, no pubertal development, dyslipidemia in 2014, obesity, gestational hypertension, maternal weight gain above Institute of Medicine guidelines, and single parents had increased triglyceride or triglyceride/high-density lipoprotein (HDL). Adolescents with rural residence had higher HbA1c level. Conclusion. We observed that the prevalence of GLMD was high in childhood and adolescents, and rural-urban areas, sex, pubertal development, dyslipidemia in a younger age, maternal obesity, and hypertension were associated with increased GLMD risk, suggesting that implementing the community-family intervention to improve the GLMD of children is essential.
      PubDate: Wed, 08 Jun 2022 18:50:03 +000
  • Molecular Mechanisms of Hawthorn Extracts in Multiple Organs Disorders in
           Underlying of Diabetes: A Review

    • Abstract: Diabetes mellitus (DM) is one of the most important metabolic disorders associated with chronic hyperglycemia and occurs when the body cannot manage insulin secretion, insulin action, or both. Autoimmune destruction of pancreatic beta cells and insulin resistance are the major pathophysiological factors of types 1 and 2 of DM, respectively. Prolonged hyperglycemia leads to multiple organs dysfunctions, including nephropathy, neuropathy, cardiomyopathy, gastropathy, and micro- and macrovascular disorders. The basis of the metabolic abnormalities in carbohydrate, fat, and protein in diabetes is insufficient action of insulin on various target tissues. Medicinal plants are rich sources of bioactive chemical compounds with therapeutic effects. The beneficial effects of leaves, fruits, and flowers extracts of Crataegus oxyacantha, commonly called hawthorn, belonging to the Rosaceae family, are widely used as hawthorn-derived medicines. Data in this review have been collected from the scientific articles published in databases such as Science Direct, Scopus, PubMed, Web of Science, and Scientific Information Database from 2000 to 2021. Based on this review, hawthorn extracts appear both therapeutic and protective effects against diabetic-related complications in various organs through molecular mechanisms, such as decreasing triglyceride, cholesterol, very low density lipoprotein and increasing the antioxidant activity of superoxide dismutase, catalase, glutathione peroxidase, total antioxidant capacity, decreasing malondialdehyde level, and attenuating tumor necrosis factor alpha, interleukin 6 and sirtuin 1/AMP-activated protein kinase (AMPK)/nuclear factor kappa B (NF-κB) pathway and increasing the phosphorylation of glucose transporter 4, insulin receptor substrate 1, AKT and phosphoinositide 3-kinases, and attenuating blood sugar and regulation of insulin secretion, insulin resistance, and improvement of histopathological changes in pancreatic beta cells. Collectively, hawthorn can be considered as one new target for the research and development of innovative drugs for the prevention or treatment of DM and related problems.
      PubDate: Tue, 07 Jun 2022 10:50:01 +000
  • Identification of Crucial lncRNAs for Luminal A Breast Cancer through RNA

    • Abstract: Background. The growing body of evidence indicates aberrant expression of long noncoding RNAs (lncRNAs) in breast cancer. Nevertheless, a few studies have focused on identifying key lncRNAs for patients with luminal A breast cancer. In our study, we tried to find key lncRNAs and mRNAs in luminal A breast cancer. Methods. RNA sequencing was performed to identify differentially expressed mRNAs (DEmRNAs) and differentially expressed lncRNAs (DElncRNAs) in luminal A breast cancer. The protein-protein interaction (PPI), DElncRNA-DEmRNA coexpression, DElncRNA-nearby DEmRNA interaction networks, and functional annotation were performed to uncover the function of DEmRNAs. Online databases were used to validate the RNA sequencing result. The diagnostic value of candidate mRNAs was evaluated by receiver operating characteristic (ROC) curve analysis. Results. A total number of 1451 DEmRNAs and 272 DElncRNAs were identified. Several hub proteins were identified in the PPI network, including TUBB3, HIST2H3C, MCM2, MYOC, NEK2, LIPE, FN1, FOXJ1, S100A7, and DLK1. In the DElncRNA-DEmRNA coexpression, some hub lncRNAs were identified, including AP001528.2, LINC00968, LINC02202, TRHDE-AS1, LINC01140, AL354707.1, AC097534.1, MIR222HG, and AL662844.4. The mRNA expression result of TFF1, COL10A1, LEP, PLIN1, PGM5-AS1, and TRHDE-AD1 in the GSE98793 was consistent with the RNA sequencing result. The protein expression results of TUBB3, MCM2, MYOC, FN1, S100A7, and TFF1 were consistent with the mRNA expression result COL10A1, LEP, PLIN1, PGM5-AS1, and TRHDE-AD1 were capable of discriminating luminal A breast cancer and normal controls. Four lncRNA-nearby and coexpressed mRNA pairs of HOXC-AS3-HOXC10, AC020907.2-FXYD1, AC026461.1-MT1X, and AC132217.1-IGF2 were identified. AMPK (involved LIPE and LEP) and PPAR (involved PLIN1) were two significantly enriched pathways in luminal A breast cancer. Conclusion. This study could be helpful in unraveling the pathogenesis and providing novel therapeutic strategies for luminal A breast cancer.
      PubDate: Thu, 02 Jun 2022 11:05:01 +000
  • Age, Body Mass Index, and Waist-to-Hip Ratio Related Changes in Insulin
           Secretion  and  Insulin Sensitivity in Women  with Polycystic Ovary
           Syndrome: Minimal Model Analyses

    • Abstract: Insulin resistance is believed to be an integral component of the polycystic ovary syndrome (PCOS). Beta (ß) cell dysfunction is also found in PCOS. In the study, we determined the influence of age, body mass index (BMI), and waist-to-hip ratio (WHR) on insulin response to oral glucose load (OGTT) and on insulin sensitivity (Si) and ß-cell function in young women with PCOS. One hundred fourteen patients with PCOS and 41 controls with normal basal plasma glucose were studied. A 75-g OGTT was performed to determine glucose tolerance and insulin response. Insulin sensitivity and ß-cell function were studied using a modified frequently sampled IV glucose tolerance test (FISGTT) to determine the acute insulin response (AIRG), as well as Si by minimal model analysis. Si was decreased in PCOS women (2.49 0.18 vs. 3.41 ± 0.36, ), but no difference in AIRG existed between the PCOS and control group (75.1 ± 4.6 vs. 63.4 ± 4.6, ). BMI and WHR correlated negatively with Si (r = −0.43; r = −0.289, , respectively), but not with AIRG (r = 0.116; r = −0.02, , respectively). Increasing age correlated negatively with AIRG (r = −0.285, ). There was a significant interaction between disease (PCOS), BMI, and WHR on Si as well as between age and PCOS on AIRG. Thus, patients below the age of 25 with PCOS showed enhanced AIRG (89.5 ± 7.1 vs. 65.1 ± 6.7, ) and decreased Si (2.43 ± 0.25 vs. 4.52 ± 0.62, ) compared to age-matched controls. In conclusion, these data suggest that not all patients with PCOS have basal and stimulated hyperinsulinemia, insulin resistance, and impaired glucose tolerance. Based on these data in young PCOS subjects, the development of insulin resistance and T2DM may be prevented with appropriate treatment strategies.
      PubDate: Wed, 18 May 2022 10:20:01 +000
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Heriot-Watt University
Edinburgh, EH14 4AS, UK
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